Comparison of Rate of Tooth Movement Between MOPs vs MOPs & LLLT Combined

June 1, 2026 updated by: Riphah International University

Comparison of Rate of Tooth Movement Between Micro-osteoperforations Versus Micro-osteoperforations and Low Level Laser Therapy Combined

Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance.

To address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement.

Studies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored.

This study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

INTRODUCTION

Orthodontic treatment is often prolonged, requiring years to achieve desirable outcomes. The prolonged duration of treatment increases the risk of complications such as root resorption, periodontal damage, and patient non-compliance.

To address these concerns, various methods have been explored to accelerate orthodontic tooth movement, including pharmacological agents, mechanical vibration, corticotomies, and minimally invasive techniques like Micro-Osteoperforations (MOPs) and Low-Level Laser Therapy (LLLT). Micro-Osteoperforations (MOPs) have gained popularity as a minimally invasive technique that enhances bone remodeling by inducing a localized inflammatory response, thereby accelerating tooth movement.

Studies have shown that MOPs can effectively stimulate the expression of cytokines, increasing osteoclastic activity and facilitating rapid orthodontic tooth movement. However, the extent of its effectiveness varies among individuals, necessitating additional interventions to maximize efficiency. Low-Level Laser Therapy (LLLT), also known as photobiomodulation, is another promising adjunct in orthodontics. LLLT has been reported to enhance cellular activity, promote osteoblastic and osteoclastic function, and improve tissue healing, leading to accelerated tooth movement. Several studies suggest that LLLT alone can expedite orthodontic treatment, but its combination with MOPs has not been extensively explored.

This study aims to compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT. By evaluating these two techniques, this research seeks to determine whether LLLT enhances the effectiveness of MOPs in accelerating tooth movement. The findings of this study could provide valuable insights into optimizing orthodontic treatment duration while minimizing potential risks and discomfort for patients.

OBJECTIVE: To compare the rate of orthodontic tooth movement between MOPs alone and MOPs combined with LLLT.

HYPOTHESIS:

Null Hypothesis (H₀):

There is no significant difference in the rate of tooth movement between patients who undergo Micro-Osteoperforations (MOPs) alone and those who undergo Micro-Osteoperforations combined with Low-Level Laser Therapy (LLLT).

Alternative Hypothesis (H₁):

The rate of tooth movement is significantly higher in patients who undergo Micro-Osteoperforations combined with Low-Level Laser Therapy (LLLT) compared to those who undergo Micro-Osteoperforations (MOPs) alone.

OPERATIONAL DEFINITIONS:

  • Rate of Tooth Movement: The rate of tooth movement refers to the measurable change in the position of a tooth over a specific period of time, expressed in millimeters per month. This measurement is typically taken at regular intervals using clinical assessments, such as digital calipers or radiographs (e.g., periapical radiographs or CBCT scans) to accurately track the movement of the tooth. The rate of tooth movement is calculated by dividing the total distance moved by the number of months it takes to achieve that movement.
  • Visual Analog Scale (VAS): The Visual Analog Scale (VAS) is a simple and widely used scale that provides a continuous measure of intensity along a straight line, typically 10 cm long. One end of the line represents no pain (usually labeled as "0"), and the other end represents the worst possible pain (labeled as "10").

  • Root resorption: It is measured as the loss of root structure, quantified by the degree of reduction in root length or volume. It will be assessed using Cone Beam Computed Tomography (CBCT) or periapical radiographs, where the degree of resorption is categorized into different levels based on observable changes in the root morphology:

    • None: No evidence of root resorption.
    • Mild: Minimal loss of root structure, less than 10% of the root length or volume affected.
    • Moderate: Moderate loss of root structure, between 10-30% of the root length or volume affected.
    • Severe: Significant loss of root structure, greater than 30% of the root length or volume affected.

MATERIAL & METHOD:

Study Design: Split mouth Randomized controlled trial (One side of each patient's mouth will be designated as Group A, while the other side will be assigned to Group B)

SELECTION CRITERIA:

Inclusion Criteria:

  • Patients aged 12-30 years requiring fixed orthodontic treatment.
  • Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.
  • No history of previous orthodontic treatment.
  • Patients with indications for the extraction of the first premolars on both sides of the maxilla.

Exclusion criteria:

  • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).
  • Smokers and individuals with poor oral hygiene.
  • Pregnant or lactating women.

Sample Size:

It will be a randomized controlled trial. Each patient would receive MOP on one side and MOP + Laser on the other side, randomly assigned.

33 subjects, for a total sample size of 66. n = 2(1.96 + 0.84)2 (0.48)2 / (0.53)2 = 32.4

Materials:

Diode Laser: Woodpecker LX16 Plus Diode Laser (976± 20nm) Micro-osteoperforations: GNI Mini Screws dimensions 1.8mm to 8mm

Methodology:

After the approval of ethical committee of Riphah International University, Islamabad, Pakistan, patients fulfill the selection criteria will be enrolled. A written informed consent will be taken from patients. A total of 66 participants will be enrolled in the study. One side of each patient's mouth will be designated as Group A, while the other side will be assigned to Group B using the block randomization method. Group A will undergo micro-osteoperforations at designated sites along the extraction space, while Group B will receive micro-osteoperforations in combination with Low-Level Laser Therapy at specified intervals. The intervention protocol consists of two approaches: Micro-Osteoperforations (MOPs) alone and Micro-Osteoperforations combined with Low-Level Laser Therapy (LLLT). MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement. These perforations are intended to stimulate localized bone remodeling by enhancing osteoclastic activity, thereby facilitating a faster rate of tooth movement. For patients in the LLLT group, a diode laser with a wavelength of 600-1000 nm will be applied at predetermined power settings and specific time intervals following the MOPs procedure. The application of LLLT is expected to enhance cellular activity, promote osteoblastic and osteoclastic function, and accelerate tooth movement while potentially reducing post-procedural discomfort and inflammation. The primary outcome measure of this study will be the rate of orthodontic tooth movement, quantified in millimeters per month to determine the efficacy of each intervention. Secondary outcome measures will include pain levels, assessed using the Visual Analog Scale (VAS) to evaluate patient discomfort; root resorption, measured through Cone Beam Computed Tomography (CBCT) or periapical radiographs to assess any structural changes in dental roots; and patient compliance and satisfaction, which will be recorded through self-reported feedback and adherence to treatment protocols. A predesign structured questionere will be used to collect data.

DATA ANALYSIS PROCEDURE: Gathered data will be entered and analyzed by the computer software Statistical Package for Social Sciences (SPSS) Version 25. The results for all Quantitative variables: age, Rate of tooth movement, Pain levels and Root resorption will be expressed as mean ± SD. Frequency and percentages will be calculated for categorical variables such as gender, different levels of pain (e.g., no pain, mild pain, moderate pain, severe pain), Root resorption e.g., none, mild, moderate, severe and Patient compliance and satisfaction. Effect modifier such as age, gender, will be addressed through post stratification. Post stratification chi square test or Fisher's exact test will be applied in which p value of < 0.05 will be significant.

Study Type

Interventional

Enrollment (Estimated)

33

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Pakistan
    • Punjab Province
      • Islamabad, Punjab Province, Pakistan
        • Islamic International Dental Hospital
        • Contact:
        • Principal Investigator:
          • Nauman Arshad, MDS
        • Sub-Investigator:
          • Ulfat Bashir, FCPS, MPH

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

Yes

Description

Inclusion Criteria:

  • • Patients aged 12-30 years requiring fixed orthodontic treatment.

    • Patients with Class I or mild-to-moderate Class II malocclusion requiring canine retraction.
    • No history of previous orthodontic treatment.
    • Patients with indications for the extraction of the first premolars on both sides of the maxilla.

Exclusion Criteria:

  • • Patients with systemic conditions affecting bone metabolism (e.g., osteoporosis, diabetes).

    • Smokers and individuals with poor oral hygiene.
    • Pregnant or lactating women.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Right side LLLT + MOP, Left side MOP only
Group A will undergo micro-osteoperforations on Left side and Microosteoperforations with Low Level Laser Therapy combined on Right side of the Maxillary Arch
Other: Micro-osteoperforation
MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm
Device: Low Level Laser Therapy and Micro-osteoperforations Combined

Woodpecker LX16 Plus Diode Laser (976± 20nm) will be applied at 5W and Frequency of 10000 Hz for 8 seconds producing a total of 8J Energy.

MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm
Experimental: Right side MOP only, Left side LLLT + MOP
Group B will undergo micro-osteoperforations on Right side and Microosteoperforations with Low Level Laser Therapy combined on Leftside of the Maxillary Arch
Other: Micro-osteoperforation
MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm
Device: Low Level Laser Therapy and Micro-osteoperforations Combined

Woodpecker LX16 Plus Diode Laser (976± 20nm) will be applied at 5W and Frequency of 10000 Hz for 8 seconds producing a total of 8J Energy.

MOPs will be performed using a sterile surgical instrument under local anesthesia, ensuring patient comfort during the procedure. Small perforations will be created in the alveolar bone adjacent to the tooth undergoing orthodontic movement along the long axis of the tooth with rule of 3, 3mm difference between three sites along the distal root of Canine. The intervention was repeated after 3 weeks interval for 9 weeks. GNI Mini Screws 1.8 x 8 mm

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Rate of Tooth Movement
Time Frame: 3 weeks
To compare the rate of orthodontic tooth movement while retraction of Maxillary Canine in extracted first premolar sight between MOPs alone and MOPs combined with LLLT. The mesurements were done on Intraoral scan of Maxilla, before the experiment and after 9 weeks, the MOPs and LLLT were repeated after every 3 weeks.
3 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Root Resorption
Time Frame: 3 weeks

: It is measured as the loss of root structure, quantified by the degree of reduction in root length or volume. It will be assessed using Cone Beam Computed Tomography (CBCT) or periapical radiographs, where the degree of resorption is categorized into different levels based on observable changes in the root morphology:

  • None: No evidence of root resorption.
  • Mild: Minimal loss of root structure, less than 10% of the root length or volume affected.
  • Moderate: Moderate loss of root structure, between 10-30% of the root length or volume affected.
  • Severe: Significant loss of root structure, greater than 30% of the root length or volume affected.
3 weeks
Pain in each visit
Time Frame: 3 weeks
To measure pain in each visit, Visual Analog Scale (VAS) is used.It is a simple and widely used scale that provides a continuous measure of intensity along a straight line, typically 10 cm long. One end of the line represents no pain (usually labeled as "0"), and the other end represents the worst possible pain (labeled as "10").
3 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Riphah International University

Investigators

  • Principal Investigator: Ulfat Bashir, Riphah International University

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

June 1, 2026

Primary Completion (Estimated)

September 1, 2026

Study Completion (Estimated)

December 1, 2026

Study Registration Dates

First Submitted

June 1, 2026

First Submitted That Met QC Criteria

June 1, 2026

First Posted (Actual)

June 4, 2026

Study Record Updates

Last Update Posted (Actual)

June 4, 2026

Last Update Submitted That Met QC Criteria

June 1, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IIDC/IRC/2025 Nauman Arshad

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

Yes

product manufactured in and exported from the U.S.

Yes

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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