Validation of a New System for Measuring Ventilation and CO₂ Production (PAIRFS)

Comparison of a New Gas Exchange Measurement System During Exercise With a Reference System

Gas exchange measurement systems are complex and require specialized facilities and expertise. As a result, access to these measurements remains limited, particularly in the field of sports performance. The aim of this validation study was to compare measurements obtained with a reference device and a new portable system.

Study Overview

• Status: Not yet recruiting
• Conditions: Healhty
• Intervention / Treatment: Device: ZoneX

Detailed Description

Exercise gas exchange measurement is the gold-standard method for assessing maximal and submaximal aerobic performance. The measured variables are essential for the objective evaluation of exercise performance.

These parameters are used to assess an individual's performance level, determine training zones, and thereby personalize training programs. Their accuracy is therefore of critical importance.

However, the assessment of ventilatory parameters is complex, as it relies on measurements of airflow (using pneumotachographs) and gas concentrations in inspired and expired air (using O₂- and CO₂-sensitive sensors). The physical properties and composition of air differ between inspiration and expiration. In particular, the saturation of expired air with water vapor-which does not behave as an ideal gas-introduces significant challenges and can reduce the reliability of current measurement systems.

The accumulation of these individual sources of measurement error ultimately determines the overall quality and accuracy of a commercial gas exchange analysis system.

Nevertheless, athletes and coaches require regular access to these measurements in order to prescribe appropriate training intensities and evaluate training effectiveness. A recent comparative study of several commercially available portable systems highlighted substantial variability in both measurement accuracy and overall performance among existing devices. Consequently, the availability of a simple, accessible, and, above all, more accurate measurement system would represent a significant advance for the sports performance community.

• Study Type: Observational
• Enrollment (Estimated): 20

Contacts and Locations

• Study Contact: Name: Stéphane L DOUTRELEAU, MD, PhD; Phone Number: +33672511656; Email: sdoutreleau@chu-grenoble.fr
• Study Contact Backup: Name: Marie COUDURIER, MD; Phone Number: +33476765494; Email: mcoudurier3@chu-grenoble.fr

Study Locations

• France
  • Grenoble, France, 38000
    • CHUGA
    • Contact: Stéphane L DOUTRELEAU, MD, PhD; Phone Number: +33672511656; Email: sdoutreleau@chu-grenoble.fr
    • Contact: Marie COUDURIER, MD; Phone Number: +33476765494; Email: mcoudurier3@chu-grenoble.fr

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Probability Sample

Study Population

Healthy people from sports team

Description

Inclusion Criteria:

• Male or female adults (aged ≥ 18 years).
• Individuals affiliated with, or benefiting from, a health insurance or social security scheme.
• Individuals capable of understanding and signing an informed consent form.
• Individuals fluent in French.

Exclusion Criteria:

• Current tobacco smoking.
• Any cardiovascular, respiratory, or musculoskeletal condition that could impair the ability to perform a maximal exercise test.
• Individuals unwilling or unable to provide written informed consent.
• Individuals with hierarchical, family, or close personal relationships with the principal investigator.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Comparison of ventilatory flow (VE) and carbon dioxide output (VCO₂) measurements obtained using the two systems.	Equivalence of measurements within a 5% margin of error.	During the 5-minute rest period and throughout the exercise test until exhaustion. 30 minutes total.

Collaborators and Investigators

• Sponsor: University Hospital, Grenoble
• Investigators: Principal Investigator: stephane DOUTRELEAU, MD, PhD, University Grenoble Alps

Study record dates

Study Major Dates

• Study Start (Estimated): July 30, 2026
• Primary Completion (Estimated): September 30, 2026
• Study Completion (Estimated): October 30, 2026

Study Registration Dates

• First Submitted: June 15, 2026
• First Submitted That Met QC Criteria: June 29, 2026
• First Posted (Actual): June 30, 2026

Study Record Updates

• Last Update Posted (Actual): June 30, 2026
• Last Update Submitted That Met QC Criteria: June 29, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Keywords: exercise; ventilatory measurement
• Additional Relevant MeSH Terms: Behavior; Motor Activity
• Other Study ID Numbers: 38RC25.0261

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No