Internal Organ and Musculoskeletal Assessment in Hypothyroidism (HYPOMORPH) (HYPOMORPH)

Morphometric Characteristics of Internal Organs and Morphofunctional Status of the Musculoskeletal System in Patients With Hypothyroidism

This hospital-based observational cross-sectional study aims to investigate the morphometric characteristics of internal organs and the morphofunctional status of the musculoskeletal system in adult patients with previously diagnosed hypothyroidism. The study will evaluate ultrasonographic morphometric characteristics of the liver, pancreas, and kidneys, as well as anthropometric and functional characteristics of the musculoskeletal system. Associations between these outcomes and clinical characteristics, anthropometric parameters, physical activity, and laboratory findings will also be assessed. The study is expected to identify accessible clinical, anthropometric, and functional markers associated with morphometric and musculoskeletal changes in patients with hypothyroidism, thereby improving risk assessment and early detection of systemic involvement.

Study Overview

• Status: Not yet recruiting
• Conditions: Hypothyroidism
• Intervention / Treatment: Diagnostic test: Comprehensive Morphometric and Functional Assessment

Detailed Description

Hypothyroidism is one of the most common endocrine disorders and is associated with structural and functional alterations affecting multiple organs and body systems. In addition to its metabolic consequences, hypothyroidism may influence the morphology of internal organs and the functional status of the musculoskeletal system. However, comprehensive hospital-based studies evaluating these manifestations simultaneously remain limited.

This observational hospital-based cross-sectional study will include adult patients with a previously established diagnosis of hypothyroidism who are receiving care at participating healthcare institutions. All participants will undergo standardized clinical examination, anthropometric assessment, ultrasonographic evaluation of internal organs, functional assessment of the musculoskeletal system, and laboratory testing according to the study protocol.

Ultrasonographic evaluation will include morphometric assessment of the liver, pancreas, and kidneys using standardized examination protocols. Anthropometric assessment will include body height, body weight, body mass index, waist circumference, hip circumference, calf circumference, arm span, and derived anthropometric indices. Functional assessment of the musculoskeletal system will include handgrip strength, the Five Times Sit-to-Stand Test, and other validated functional assessments specified in the protocol.

The primary outcomes are ultrasonographic morphometric changes of the liver, pancreas, and kidneys, together with morphofunctional impairment of the musculoskeletal system.

Secondary analyses will evaluate associations between these outcomes and demographic characteristics, duration of hypothyroidism, thyroid hormone status, anthropometric indices, physical activity, laboratory findings, and other clinical characteristics.

The findings are expected to improve understanding of systemic manifestations of hypothyroidism and contribute to the identification of practical and inexpensive markers for the early detection of organ involvement and musculoskeletal impairment in routine clinical practice.

• Study Type: Observational
• Enrollment (Estimated): 500

Contacts and Locations

• Study Contact: Name: Abdukhalim Kh. Abdurakhimov, PhD; Phone Number: +998941010091; Email: abduhalim@adti.uz

Study Locations

• Uzbekistan
  • Andijan, Uzbekistan, 170127
    • Andijan State Medical Institute
    • Contact: Abdukhalim Kh. Abdurakhimov, PhD; Phone Number: +9988941010091; Email: abduhalimaka@mail.ru

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Adult patients with a previously established diagnosis of hypothyroidism receiving routine medical care at participating healthcare institutions.

Description

Inclusion Criteria:

• Adults aged 18-59 years.
• Previously established diagnosis of hypothyroidism.
• Receiving routine outpatient or inpatient care at participating healthcare institutions.
• Ability to undergo ultrasonographic, anthropometric, and functional assessments.
• Provision of written informed consent.

Exclusion Criteria:

• Pregnancy or lactation.
• History of thyroid malignancy.
• Acute infectious or inflammatory disease at the time of enrollment.
• Severe decompensated cardiovascular, hepatic, or renal disease preventing study procedures.
• Neurological or musculoskeletal disorders that preclude functional testing.
• Refusal or inability to provide informed consent.
• Incomplete clinical or laboratory data.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Patients With Hypothyroidism; Adult patients with a previously established diagnosis of hypothyroidism who will undergo clinical examination, anthropometric assessment, ultrasonographic evaluation of the liver, pancreas and kidneys, functional assessment of the musculoskeletal system, and laboratory testing according to the study protocol.	Diagnostic test: Comprehensive Morphometric and Functional Assessment; Participants will undergo a standardized diagnostic assessment including clinical evaluation, anthropometric measurements, ultrasonographic examination of the liver, pancreas, and kidneys, functional

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Liver Longitudinal Diameter	The longitudinal diameter of the liver will be measured by abdominal ultrasonography according to the standardized study protocol. The measurement will be recorded in centimeters (cm).	Baseline
Pancreatic Head Thickness	The anteroposterior thickness of the pancreatic head will be measured by abdominal ultrasonography according to the standardized study protocol. The measurement will be recorded in millimeters (mm).	Baseline
Kidney Length	The longitudinal length of each kidney will be measured by ultrasonography according to the standardized study protocol. Measurements will be recorded in millimeters (mm).	Baseline
Handgrip Strength	Muscle strength will be assessed using a calibrated handgrip dynamometer. Maximum grip strength will be recorded in kilograms (kg). Higher values indicate greater muscle strength.	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Five Times Sit-to-Stand Test	Lower-extremity physical function will be assessed using the Five Times Sit-to-Stand Test. The time required to complete five consecutive chair stands without using the arms will be recorded in seconds. Longer completion times indicate poorer physical performance.	Baseline
Body Mass Index	Body mass index will be calculated as body weight divided by height squared and expressed in kilograms per square meter (kg/m²).	Baseline
Waist Circumference	Waist circumference will be measured using a standardized anthropometric technique and recorded in centimeters (cm).	Baseline
Calf Circumference	Calf circumference will be measured at the point of maximum circumference and recorded in centimeters (cm).	Baseline

Collaborators and Investigators

• Sponsor: Andijan State Medical Institute

Study record dates

Study Major Dates

• Study Start (Estimated): August 1, 2026
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2028

Study Registration Dates

• First Submitted: July 8, 2026
• First Submitted That Met QC Criteria: July 14, 2026
• First Posted (Actual): July 16, 2026

Study Record Updates

• Last Update Posted (Actual): July 16, 2026
• Last Update Submitted That Met QC Criteria: July 14, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Keywords: Physical Activity; Hypothyroidism; Physical Function; Pancreas; Ultrasonography; Musculoskeletal System; Kidney; Liver; Anthropometry; Morphometry; Physical Inactivity; Cross-Sectional Study
• Additional Relevant MeSH Terms: Endocrine System Diseases; Thyroid Diseases; Behavior; Hypothyroidism; Motor Activity; Sedentary Behavior
• Other Study ID Numbers: HYPOMORPH-2026

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: The data sharing plan has not yet been finalized and will be determined after study completion in accordance with ethical, institutional, and journal requirements.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No