Ultrasound-guided Combined Perineural and Intramuscular Dextrose Injection for Management of Refractory Bell's Palsy

Ultrasound-guided Combined Perineural and Intramuscular Dextrose Injection for Management of Refractory Bell's Palsy A Prospective Study

Bell's palsy (BP) is characterized by idiopathic acute weakness of the facial muscles associated with compression of the facial nerve. The present prospective study sought to evaluate the clinical efficacy of ultrasound-guided combined perineural and intramuscular dextrose injection for management of refractory Bell's palsy. The study included 30 patients with Bell's palsy with House-Brackmann scale ≥ 3 who were refractory to standard medical treatment after 3 months of disease onset. They received ultrasound-guided combined perineural and intramuscular dextrose injection. Clinical outcome was assessed using the House-Brackmann scale.

Study Overview

• Status: Completed
• Conditions: Bell Palsy
• Intervention / Treatment: Procedure: Ultrasound-guided combined perineural and intramuscular dextrose injection.

• Study Type: Interventional
• Enrollment (Actual): 30
• Phase: Phase 4

Contacts and Locations

Study Locations

• Egypt
  • Cairo, Egypt, 247883
    • Al-Azhar University Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

- The study included 30 patients with Bell's palsy diagnosed according to the recommendations of American Academy of Otolaryngology-Head and Neck Surgery Foundation

Exclusion Criteria:

• Patients were excluded if they were previously submitted to injection therapy or surgical intervention for management of Bell's palsy. They were also excluded if they had associated mental illness or advanced systemic conditions (e.g. uncontrolled diabetes, uncontrolled hypertension, malignant disease, immunocompromised conditions).

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Interventional arm; Ultrasound-guided combined perineural and intramuscular dextrose injection.	Procedure: Ultrasound-guided combined perineural and intramuscular dextrose injection.; Ultrasound-guided combined perineural and intramuscular dextrose injection.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
House Brackmann scale	House Brackmann scale	3 months

Collaborators and Investigators

• Sponsor: Al-Azhar University

Study record dates

Study Major Dates

• Study Start (Actual): October 10, 2025
• Primary Completion (Actual): April 1, 2026
• Study Completion (Actual): April 1, 2026

Study Registration Dates

• First Submitted: July 22, 2026
• First Submitted That Met QC Criteria: July 22, 2026
• First Posted (Actual): July 27, 2026

Study Record Updates

• Last Update Posted (Actual): July 27, 2026
• Last Update Submitted That Met QC Criteria: July 22, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Mouth Diseases; Stomatognathic Diseases; Nervous System Diseases; Infections; Virus Diseases; DNA Virus Infections; Herpesviridae Infections; Cranial Nerve Diseases; Facial Nerve Diseases; Bell Palsy
• Other Study ID Numbers: 2023031799

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No