Impact of an e-Bug Educational Intervention on HPV and Meningococcal ACWY Vaccine Uptake in Middle School Students

September 11, 2026 updated by: Centre Hospitalier Universitaire de Nice

Pilot Observational Comparative Study Evaluating the Impact of the e-Bug Educational Programme on Parental Consent and HPV and Meningococcal ACWY Vaccination Coverage During the National School-Based Vaccination Campaign in a Middle School in the Alpes-Maritimes Department and PACA Region

"This study is a non-interventional observational pilot analysis assessing the possible impact of an educational programme (e-Bug) on parental consent and HPV and meningococcal ACWY vaccination uptake during the 2025-2026 national school-based vaccination campaigns in France. The study focuses on one middle school in the Alpes-Maritimes department and PACA region where teachers and the school nurse had been previously trained on vaccination and used e-Bug educational resources in class as part of routine health education. No research-related intervention was conducted, and the educational programme was not introduced or modified for the purpose of the study.

Only aggregated and anonymised vaccination data were used. These data were routinely collected by the Regional Health Agency (ARS PACA) as part of the national vaccination programme and transmitted for analysis. Aggregated data from the pilot school were compared with departmental-level outcomes to describe whether an upstream educational approach may be associated with improved parental acceptance and higher hpv and meningococcal acwy vaccination coverage. This study aims to contribute to the understanding of educational determinants of vaccine uptake in a real-life school setting without involving any participant recruitment or individual data collection."

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

53608

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • France
    • Alpes Maritimes
      • Nice, Alpes Maritimes, France, 06000
        • Chu De Nice

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Aggregated data from 5th-grade students enrolled in one pilot middle school using the e-Bug programme, compared with aggregated data from all other middle schools in the Alpes-Maritimes department and PACA region. No individual-level data were accessed.

Description

Inclusion Criteria:

  • No individual participants are enrolled. The study uses only aggregated, anonymised vaccination data routinely collected by ARS PACA.

Exclusion Criteria:

  • Not applicable. No individual-level inclusion or exclusion criteria are defined, as no participants are enrolled.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Pilot School Using e-Bug Programme
The intervention consisted of a school-based educational programme implemented before the national vaccination campaign using MenACWY-specific e-Bug educational resources. Age-appropriate classroom activities addressed meningococcal disease, transmission, disease severity, prevention, and vaccination. The intervention also involved close collaboration between teachers and the school nurse, communication with families, and active follow-up of non-responding parents.
Behavioral: e-Bug School-Based Educational Intervention
The intervention consisted of a school-based educational programme implemented before the national vaccination campaign using MenACWY-specific e-Bug educational resources. Age-appropriate classroom activities addressed meningococcal disease, transmission, disease severity, prevention, and vaccination. The intervention also involved close collaboration between teachers and the school nurse, communication with families, and active follow-up of non-responding parents.
Other Middle Schools in Alpes-Maritimes Department and PACA region
Students participated in the national school-based vaccination campaign and received the standard information materials provided as part of the campaign. No MenACWY-specific e-Bug educational intervention was implemented in these schools during the study period.
Behavioral: Standard School-Based Vaccination Campaign
Students participated in the national school-based vaccination campaign and received the standard information materials provided as part of the campaign. No MenACWY-specific e-Bug educational intervention was implemented in these schools during the study period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
HPV and Meningococcal ACWY vaccination uptake (1st and 2nd doses) in the pilot school compared with departmental and region data
Time Frame: From (start of 2025 HPV and Meningococcal ACWY vaccination campaign) to (end of 2025-2026)
Aggregated rates of HPV and Meningococcal ACWY vaccination uptake (first and second doses) among 5th-grade students in the pilot middle school using the e-Bug educational programme, compared with aggregated departmental and region vaccination rates from all other middle schools in the PACA area.
From (start of 2025 HPV and Meningococcal ACWY vaccination campaign) to (end of 2025-2026)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Parental consent rate (acceptability)
Time Frame: One school years 2025-2026
Aggregated proportion of parents providing positive consent for HPV and Meningococcal ACWY vaccination in the pilot school, compared with aggregated departmental and region consent rates collected by ARS PACA during the 2025-2026 school-based campaigns.
One school years 2025-2026
Response rate (return of vaccination authorisation forms)
Time Frame: one school years: 2025-2026
Aggregated rate of returned parental authorisation forms (regardless of response: yes/no) in the pilot school compared with departmental and region response rates.
one school years: 2025-2026

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Centre Hospitalier Universitaire de Nice

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 1, 2026

Primary Completion (Actual)

June 30, 2026

Study Completion (Actual)

September 1, 2026

Study Registration Dates

First Submitted

September 11, 2026

First Submitted That Met QC Criteria

September 11, 2026

First Posted (Actual)

September 17, 2026

Study Record Updates

Last Update Posted (Actual)

September 17, 2026

Last Update Submitted That Met QC Criteria

September 11, 2026

Last Verified

September 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • 26SantéMentale02

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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