Ambulatory continuous interscalene nerve blocks decrease the time to discharge readiness after total shoulder arthroplasty: a randomized, triple-masked, placebo-controlled study
Brian M Ilfeld, Krista Vandenborne, Pamela W Duncan, Daniel I Sessler, F Kayser Enneking, Jonathan J Shuster, Douglas W Theriaque, Terese L Chmielewski, Eugene H Spadoni, Thomas W Wright, Brian M Ilfeld, Krista Vandenborne, Pamela W Duncan, Daniel I Sessler, F Kayser Enneking, Jonathan J Shuster, Douglas W Theriaque, Terese L Chmielewski, Eugene H Spadoni, Thomas W Wright
Abstract
Background: A continuous interscalene nerve block (CISB) may be used to provide analgesia after shoulder arthroplasty. Therefore, inpatient stays may be shortened if CISB (1) provides adequate analgesia without intravenous opioids and (2) improves shoulder mobilization. This study investigated the relationship between ambulatory CISB and the time to reach three discharge criteria after shoulder arthroplasty.
Methods: Preoperatively, patients received a CISB. All patients received a perineural 0.2% ropivacaine infusion from surgery until 06:00 the following morning, at which time they were randomly assigned either to continue perineural ropivacaine or to switch to normal saline. The primary endpoint was the time from the end of surgery until three discharge criteria were attained (adequate analgesia, independence from intravenous analgesics, and tolerance to 50% of shoulder motion targets). Patients were discharged home as early as the afternoon after surgery with their CISB using a portable infusion pump.
Results: Patients receiving perineural ropivacaine (n = 16) attained all three discharge criteria in a median (10th-90th percentiles) of 21 (16-41) h, compared with 51 (37-90) h for those receiving perineural normal saline (n = 13, P < 0.001). Unlike patients receiving perineural ropivacaine, patients receiving perineural normal saline often required intravenous morphine, but still experienced a higher degree of pain and tolerated less external rotation.
Conclusions: An ambulatory CISB considerably decreases the time until readiness for discharge after shoulder arthroplasty, primarily by providing potent analgesia that permits greater passive shoulder movement and the avoidance of intravenous opioids. Additional research is required to define the appropriate subset of patients and assess the incidence of complications associated with earlier discharge.
Source: PubMed
Upcoming Clinical Trials
-
Fred Hutchinson Cancer CenterPromiCell Therapeutics, Inc.Not yet recruitingStage IVB Prostate Cancer AJCC v8 | Metastatic Castration-Resistant Prostate AdenocarcinomaUnited States
-
Arizona State UniversityNot yet recruitingExercise | Blood Pressure | Nutrition KnowledgeUnited States
-
Oregon Health and Science UniversityInSightecNot yet recruiting
-
Tongji HospitalNot yet recruiting
-
Sakarya UniversityNot yet recruitingPeripheral Artery Disease | Atherectomy in Diseased Lower Extremity ArteriesTurkey (Türkiye)
-
Ziauddin UniversityNot yet recruitingSacroiliac Joint Dysfunction
-
Eli Lilly and CompanyNot yet recruitingObesity | Diabetes Mellitus, Type 1 | OverweightUnited States
-
Cairo UniversityNot yet recruitingDental Caries | Cervical Caries
-
IRCCS San RaffaeleNot yet recruitingPancreatic Neoplasms | Radiomics | Pancreatic Ductal Adenocarcinoma (PDAC) | Endoscopic Ultrasound (EUS) | Artificial Intelligence (AI)Italy
-
MediLink Therapeutics (Suzhou) Co., Ltd.Not yet recruitingMetastatic Pancreatic Cancer | Pancreatic Ductal Adenocarcinoma (PDAC)China
-
National University of Modern LanguagesNot yet recruitingBody Dysmorhpic Disorder | Positive Psychology
-
Shanghai Minwei Biotechnology Co., LtdRecruitingType 2 Diabetes Mellitus (T2DM) | MASH - Metabolic Dysfunction-Associated Steatohepatitis | Overweight , ObesityChina