Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis
Analysis of Respiratory Mechanics in Patients With Rheumatoid Arthritis: Effect of Duration of Disease
Rheumatoid arthritis (RA) is an autoimmune disease of unknown etiology characterized by peripheral polyarthritis, symmetric, which leads to joint destruction and deformity. It is estimated that the RA reaches about 0.5% of the population. According to data from DATASUS, was responsible for 26,671 hospitalizations, 229 deaths and cost exceeding R$ 20 million in 2005-2007.
The main bodily changes are related to joint problems, however, systemic manifestations are also found in organs such as lung and heart. Although cardiovascular diseases are the most responsible of the deaths AR, pulmonary complications are common and account for 10% to 15% of all mortality. Anaya and colleagues point out that the pulmonary involvement contributes significant morbidity and mortality in these patients. Although pulmonary involvement is a frequent manifestation in RA, the prevalence and nature of rheumatoid lung disease has not yet been precisely established. Several lung disorders such as interstitial pulmonary fibrosis, pulmonary nodules and bronchiolitis may ocorrer1. Laitinen et al point out that studies of lung function appear to be a valuable helper for radiography in the evaluation of pulmonary involvement in connective tissue diseases. Previous studies indicate that patients with RA have an increased incidence of abnormal lung function, according to assessments including spirometry, lung volume tests and diffusion capacity of carbon monoxide.
Thus, the main objective of this study is to analyze the respiratory mechanics of patients with RA. Specific objectives were to seek to understand whether a relationship exists between duration of rheumatoid disease and lung function in these patients.
For this, the investigators used 18 subjects in the control group, free of pulmonary disease and / or heart, all nonsmokers. In the RA group, a total of 72 patients divided into 4 groups of 18 volunteers each, classified according to disease duration (0-5 years, 6-10 years, 11-15 years and> or = 16 years). It is noteworthy that all patients in the RA group will also be non-smokers, since it is already known in the literature that smoking impairs lung function. All individuals will perform the function test with a trained technician and qualified to function. The examinations will be conducted: Forced oscillation technique and spirometry, in that order.
Přehled studie
Postavení
Podmínky
Typ studie
Zápis (Očekávaný)
Kontakty a umístění
Studijní místa
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Rio de Janeiro, Brazílie, 21550-013
- Nábor
- Laboratório de Instrumentação Biomédica
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Kontakt:
- Alvaro Camilo D Faria
- Telefonní číslo: (5521)78201688
- E-mail: acdffisio@gmail.com
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Vrchní vyšetřovatel:
- Alvaro Camilo D Faria
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Vrchní vyšetřovatel:
- Pedro L de Melo
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Vrchní vyšetřovatel:
- Geraldo Castelar
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Vrchní vyšetřovatel:
- Agnaldo J Lopes
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Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Metoda odběru vzorků
Studijní populace
The control group will consist of healthy subjects, nonsmokers, who had no episode of respiratory infection thirty days before the examinations.
The group of patients with rheumatoid arthritis will be comprised of individuals treated at the Department of Rheumatology (Hospital Universitártio Pedro Ernesto) nonsmokers, who had no episode of respiratory infection thirty days before the examinations.
Popis
Inclusion Criteria:
- Volunteers with Rheumatoid Arthritis for Patients Group;
- Volunteers without any respiratory disease for the control group.
Exclusion Criteria:
Smokers
Studijní plán
Jak je studie koncipována?
Detaily designu
- Časové perspektivy: Průřezový
Kohorty a intervence
Skupina / kohorta |
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Control Group
Group of nonsmokers individuals without respiratory disease.
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RA patients 1
RA patients nonsmokers with up to five years of disease.
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RA group 2
RA patients nonsmokers with six to ten years of disease.
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RA group 3
RA patients nonsmokers with eleven to fifteen years of disease.
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RA group 4
RA patients nonsmokers with sixteen or more years of disease
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Spolupracovníci a vyšetřovatelé
Vyšetřovatelé
- Ředitel studie: Pedro L de Melo, State University of Rio de Janeiro
Publikace a užitečné odkazy
Obecné publikace
- Faria AD, Lopes AJ, Jansen JM, Pinheiro GC, Melo PL. Diagnostic performance of the Forced Oscillation Technique in the detection of early respiratory changes in rheumatoid arthritis. Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6034-7. doi: 10.1109/IEMBS.2010.5627605.
- Faria AC, Barbosa WR, Lopes AJ, Pinheiro Gda R, Melo PL. Contrasting diagnosis performance of forced oscillation and spirometry in patients with rheumatoid arthritis and respiratory symptoms. Clinics (Sao Paulo). 2012 Sep;67(9):987-94. doi: 10.6061/clinics/2012(09)01.
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia
Primární dokončení (Očekávaný)
Dokončení studie (Očekávaný)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Odhad)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Odhad)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
Další identifikační čísla studie
- AR-01
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