- ICH GCP
- Registr klinických studií v USA
- Klinická studie NCT03794791
A Comprehensive HBsAg-positive Patients Centered Screening Strategy (CHARSET)
A Comprehensive HBsAg-positive Patients Centered Screening Strategy Targeting HCV(Hepatitis C) Micro-elimination (CHARSET) in Chongqing, China Establishment of a Model Toward HCV Elimination
HBV(hepatitis B virus) /HCV(hepatitis C virus) co-infection may accelerate liver disease progression and increase the risk of HCC(Hepatocellular Carcinoma)development. It is reported HCV co-infection harmfully affects liver fibrosis in HBV patients, while decompensated cirrhosis is increased in co-infected patients compared with HBV- or HCV- mono-infected patients. One meta-analysis having pooled 39 studies performed in China reported that around 5% of HCC was associated with HCV infection alone and 6% with co-infection of HBV + HCV. However, the exact prevalence of HCV infection in HBsAg(Hepatitis B virus surface antigen)(+) cohort is actually unknown. It is estimated to be between 0.7% and 16%, a percentage that varies over a wide range among several studies from literature, mainly depending on different geographical distribution and study population. However, in regions where HBV is endemic, such as China with a HBsAg positive rate of 7.18%, the probability of co-infection increases due to a similar transmission route, especially in patients with high risk of HCV infection, like dialysis, HIV infection, organ transplantation, sex workers, drug abuser, tattoo, piercing, blood donation, history of scaling or dental filling, HCV family history and so on.
As for China, the awareness of HCV infection is much lower than HBV because the occult of HCV infection, also because governments as well as medical authorities didn't input enough resources to disease education. Up to now, the national HCV elimination in China is daunting because of barriers in HCV awareness/link to care, and lack of well-established strategies. On the contrary, HBV infection has been widely known and educated to general population. As an add-on benefit, it might be relatively easier to conduct HCV screening test among those HBsAg-positive population. HCV elimination in high-risk subgroups from the basis in HBV population can be achieved with greater possibility and such model could be further shared to health care societies.
Přehled studie
Postavení
Intervence / Léčba
Detailní popis
1. Objective:
Primary objective:
Evaluate value of HCV education in HCV screening and diagnosis in HBsAg(+) patients
Secondary objectives:
- Evaluate prevalence of HCV co-infection in HBV cohort in Chongqing, China
- Assess awareness of HCV infection in HBV/HCV cohort and analysis of risk factors
2. Research methods
A. Evaluate value of HCV education in HCV screening and diagnosis in HBsAg(+) patients About 300 patients screened for HBsAg every day in the second affiliated hospital of Chongqing Medcial University. So there will be about 200,000 patients tested for HBsAg for 2 years, among which 5% is estimated to be HBsAg (+) (n=10,000) and will be informed. All of them will be asked to follow-up in Infectious Disease Department of the hospital and be divided into two groups by 1:1 randomization. Patients in the first group will not receive any disease education, but the investigators will record how many patients propose to take anti-HCV test voluntarily after those patients know the result of HBsAg test of their own (The acceptation rate of anti-HCV test is A). The second group will receive education about HCV infection as well as HBV/HCV co-infection and then be asked whether those patients are willing to do anti-HCV test or not (The acceptation rate of anti-HCV test is B). Education Methods including video playing of HCV Introduction (disease profile, risk factors for infection, outcomes, HBV/HCV coinfection, reinfection, etc) for 5 min, booklets of relative information distribution, physicians and nurses consulting in clinic. Diagnosis rate of HCV coinfection is C and D for the two groups, respectively.The investigators anticipate B will be higher than A and D will be higher than C, which reflects impact from disease education. Considering some patients with HBsAg(+) might not be willing to be involved in the randomization part or lost to follow-up, the investigators presuppose sample size to be 3,000 for each group for evaluation importance of education.
B. Evaluate prevalence of HCV co-infection in HBV Cohort in Chongqing, China Actually all patients with HBsAg(+) (n=10,000) will be tested for anti-HCV with blood samples and the positive ones will be informed and suggested to do HCV RNA test to get an actual prevalence of HCV co-infection in HBV cohort in Chongqing.The investigators estimate about 16% of patients (1600 for 2 years) with HBsAg (+) are positive for anti-HCV, among which about 1200 patients are positive for HCV RNA test. These patients will be diagnosed as HCV infection and will go genotyping as well as link to care.
C. Awareness of HCV infection in HBV/HCV Cohort and analysis of risk factors All patients who are HBsAg(+) will be asked to finish questionnaires, including basic information, demographic information, risk factors for HBV or HCV infection (dialysis, HIV infection, organ transplantation, sex workers, drug abuser, tattoo, piercing, blood donation, history of scaling or dental filling, HCV family history and so on), awareness of their own HBV or HCV infection, etc.
3. Which, if any, policymakers will be engaged and how.
A. For Government Results of this program may enable government including public health officials to identify where to strengthen efforts. The investigators will get evidence to show the difference of screening and diagnosis rate of HCV infection between HBsAg(+) patients who received disease education and the ones who didn't. Elimination of the HCV as public health threats by 2030 might need to be based on patient education.
B. For Reimbursement Bureau So far there is not enough data on epidemiology to accurately assess potential HCV infection in HBsAg(+) patients. The entire hepatitis elimination effort depends on improving the availability of reliable data to describe the epidemiology of HCV. By executing this program the investigators will get the prevalence of HCV infection in HBsAg(+) patients in Chongqing and there is big possibility that the data is much higher than in general population.The investigators want to let the reimbursement bureau know anti-HCV and RNA test in HBsAg(+) cohort may results in better cost effectiveness in HCV diagnosis and treatment. Reimbursement in such population may be considered.
C. For Other Medical Units Two press conferences will be held at the beginning and at the end of CHARSET program to advocate the importance of increasing HCV awareness, link-to-treatment and HCV elimination. The program will also be posted on social media like WEIBO/WECHAT (something like facebook/twitter in China) and website of the second affiliated hospital of Chongqing Medical University. Because of acquisition of higher HCV screening and diagnosis rate, this model could be generalized in other medical units to benefit more patients.
4. Study Duration (in months) 24 months
Typ studie
Zápis (Aktuální)
Kontakty a umístění
Studijní místa
-
-
Chongqing
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Chongqing, Chongqing, Čína, 400010
- The 2nd affiliated Hospital of Chongqing Medical University
-
-
Kritéria účasti
Kritéria způsobilosti
Věk způsobilý ke studiu
- Dítě
- Dospělý
- Starší dospělý
Přijímá zdravé dobrovolníky
Pohlaví způsobilá ke studiu
Metoda odběru vzorků
Studijní populace
Popis
Inclusion Criteria:
- HBsAg(+) patients
Exclusion Criteria:
- none
Studijní plán
Jak je studie koncipována?
Detaily designu
- Observační modely: Kohorta
- Časové perspektivy: Budoucí
Kohorty a intervence
Skupina / kohorta |
Intervence / Léčba |
---|---|
education
Education will be used to see whether or not improve the HCV screening and diagnosis in HBsAg(+) patients.
Blood test ,HCV-RNA quantification test and HCV genotyping will be employed to evaluate the prevalence of HBV-HCV co-infection.
Awareness of HCV infection in HBV/HCV cohort and analysis of risk factors will also be assessed.
|
Education Methods including video playing of HCV Introduction (disease profile, risk factors for infection, outcomes, HBV/HCV coinfection, reinfection, etc) for 5 min, booklets of relative information distribution, physicians and nurses consulting in clinic.
Ostatní jména:
|
no education
There is no education at all.Screening and diagnosis of HCV infection in HBsAg(+) patients are based on voluntary.
Blood test ,HCV-RNA quantification test and HCV genotyping will still be employed to evaluate the prevalence of HBV-HCV co-infection.
Awareness of HCV infection in HBV/HCV cohort and analysis of risk factors will also be assessed.
|
Education Methods including video playing of HCV Introduction (disease profile, risk factors for infection, outcomes, HBV/HCV coinfection, reinfection, etc) for 5 min, booklets of relative information distribution, physicians and nurses consulting in clinic.
Ostatní jména:
|
Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
---|---|---|
Evaluate value of HCV education
Časové okno: 1 Year
|
This patients will receive education about HCV infection as well as HBV/HCV co-infection and then be asked whether they are willing to do anti-HCV test or not.
Education Methods including video playing of HCV Introduction (disease profile, risk factors for infection, outcomes, HBV/HCV coinfection, reinfection, etc) for 5 min, booklets of relative information distribution, physicians and nurses consulting in clinic.
|
1 Year
|
Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
---|---|---|
Prevalence of HCV co-infection
Časové okno: 1 Year
|
All patients with HBsAg(+) (n=10,000) will be tested for anti-HCV with blood samples and the positive ones will be informed and suggested to do HCV RNA test to get an actual prevalence of HCV co-infection in HBV cohort in Chongqing.
The investigators estimate about 16% of patients (1600 for 2 years) with HBsAg (+) are positive for anti-HCV, among which about 1200 patients are positive for HCV RNA test.
These patients will be diagnosed as HCV infection and will go genotyping as well as link to care.
|
1 Year
|
Awareness of HCV infection
Časové okno: 1 Year
|
All patients who are HBsAg(+) will be asked to finish questionnaires, including basic information, demographic information, risk factors for HBV or HCV infection (dialysis, HIV infection, organ transplantation, sex workers, drug abuser, tattoo, piercing, blood donation, history of scaling or dental filling, HCV family history and so on), awareness of their own HBV or HCV infection, etc.
|
1 Year
|
Spolupracovníci a vyšetřovatelé
Sponzor
Spolupracovníci
Publikace a užitečné odkazy
Obecné publikace
- Pol S, Haour G, Fontaine H, Dorival C, Petrov-Sanchez V, Bourliere M, Capeau J, Carrieri P, Larrey D, Larsen C, Marcellin P, Pawlostky JM, Nahon P, Zoulim F, Cacoub P, de Ledinghen V, Mathurin P, Negro F, Pageaux GP, Yazdanpanah Y, Wittkop L, Zarski JP, Carrat F; French Anrs Co22 Hepather Cohort. The negative impact of HBV/HCV coinfection on cirrhosis and its consequences. Aliment Pharmacol Ther. 2017 Dec;46(11-12):1054-1060. doi: 10.1111/apt.14352. Epub 2017 Oct 9.
- Wang M, Wang Y, Feng X, Wang R, Wang Y, Zeng H, Qi J, Zhao H, Li N, Cai J, Qu C. Contribution of hepatitis B virus and hepatitis C virus to liver cancer in China north areas: Experience of the Chinese National Cancer Center. Int J Infect Dis. 2017 Dec;65:15-21. doi: 10.1016/j.ijid.2017.09.003. Epub 2017 Sep 19.
- Papadopoulos N, Papavdi M, Pavlidou A, Konstantinou D, Kranidioti H, Kontos G, Koskinas J, Papatheodoridis GV, Manolakopoulos S, Deutsch M. Hepatitis B and C coinfection in a real-life setting: viral interactions and treatment issues. Ann Gastroenterol. 2018 May-Jun;31(3):365-370. doi: 10.20524/aog.2018.0255. Epub 2018 Mar 28.
- Wang H, Swann R, Thomas E, Innes HA, Valerio H, Hayes PC, Allen S, Barclay ST, Wilks D, Fox R, Bhattacharyya D, Kennedy N, Morris J, Fraser A, Stanley AJ, Gunson R, Mclntyre PG, Hunt A, Hutchinson SJ, Mills PR, Dillon JF. Impact of previous hepatitis B infection on the clinical outcomes from chronic hepatitis C? A population-level analysis. J Viral Hepat. 2018 Aug;25(8):930-938. doi: 10.1111/jvh.12897. Epub 2018 Apr 15.
- Lazarus JV, Wiktor S, Colombo M, Thursz M; EASL International Liver Foundation. Micro-elimination - A path to global elimination of hepatitis C. J Hepatol. 2017 Oct;67(4):665-666. doi: 10.1016/j.jhep.2017.06.033. Epub 2017 Jul 29. No abstract available.
Termíny studijních záznamů
Hlavní termíny studia
Začátek studia (Aktuální)
Primární dokončení (Aktuální)
Dokončení studie (Aktuální)
Termíny zápisu do studia
První předloženo
První předloženo, které splnilo kritéria kontroly kvality
První zveřejněno (Aktuální)
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
Naposledy ověřeno
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
- Nemoci trávicího systému
- RNA virové infekce
- Virová onemocnění
- Infekce
- Infekce přenášené krví
- Přenosné nemoci
- Onemocnění jater
- Infekce Flaviviridae
- Hepatitida, virová, lidská
- Infekce Hepadnaviridae
- DNA virové infekce
- Enterovirové infekce
- Infekce Picornaviridae
- Žloutenka typu B
- Hepatitida
- Žloutenka typu A
- Hepatitida C
Další identifikační čísla studie
- LS2018037
Plán pro data jednotlivých účastníků (IPD)
Plánujete sdílet data jednotlivých účastníků (IPD)?
Informace o lécích a zařízeních, studijní dokumenty
Studuje lékový produkt regulovaný americkým FDA
Studuje produkt zařízení regulovaný americkým úřadem FDA
produkt vyrobený a vyvážený z USA
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