Study of the Kinetics of Antibodies Against COVID-19 (SARS-CoV-2) and of Cellular Subpopulations of the Immune System
8. dubna 2022 aktualizováno: Prof Evangelos Terpos, National and Kapodistrian University of Athens
Study of the Kinetics of Antibodies Against SARS-CoV-2 and of Cellular Subpopulations of the Immune System in Volunteers Receiving the BNT162b2 Vaccine or Other Approved Vaccine Against SARS-CoV-2
Determination of both the degree and duration of the immunity provided after receiving the BNT162b2 vaccine against SARS-Cov-2.
Přehled studie
Postavení
Nábor
Intervence / Léčba
Detailní popis
The purpose of this study is to assess the kinetics of antibodies against SARS-CoV-2 as well as the kinetics of the immune system's cell subpopulations and cytokines associated with the immune system in healthy volunteers receiving the BNT162b2 vaccine against SARS-Cov-2 of the Pfizer/BioNTech companies or any other vaccine authorized and administered by the Ministry of Health.
Immunoassays will be performed at serum collection points before and after vaccination, as set out in this study.
Typ studie
Pozorovací
Zápis (Očekávaný)
600
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní kontakt
- Jméno: Ioanna Charitaki
- Telefonní číslo: +30 6976156403
- E-mail: j.charitaki@gmail.com
Studijní místa
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Athens, Řecko
- Nábor
- Department of Clinical Therapeutics, General Hospital of Athens ALEXANDRA
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Kontakt:
- Evangelos Terpos, MD
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Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Věk způsobilý ke studiu
18 let a starší (Dospělý, Starší dospělý)
Přijímá zdravé dobrovolníky
Ano
Pohlaví způsobilá ke studiu
Všechno
Metoda odběru vzorků
Vzorek nepravděpodobnosti
Studijní populace
The admission criteria include both healthy volunteers and all individuals who, according to the instructions of the Greek State are considered eligible to receive the BNT162b2 vaccine.
In particular, the study includes people with hematological malignancies or solid tumors, either receiving treatment or in remission/ follow-up, pursuant to the vaccination instructions of the Ministry of Health.
The study will also include patients with autoimmune diseases who receive or do not receive treatment for their disease.
Patients with diabetes mellitus, hypertension, heart disease, chronic renal failure of all stages (and undergoing dialysis) or other chronic diseases deemed suitable for vaccination, according to the instructions of the Ministry of Health, may also participate in the study.
Popis
Inclusion Criteria:
- Healthy volunteers and all individuals who, according to the instructions of the Greek State are considered eligible to receive the BNT162b2 vaccine
- Age ≥ 18 years old
Exclusion Criteria:
- Serious allergy problems i.e. hospitalization due to a serious allergic reaction (anaphylaxis)
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
Kohorty a intervence
Skupina / kohorta |
Intervence / Léčba |
|---|---|
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Cohort 1
Approximately 300 volunteers, healthy or with chronic diseases (diabetes mellitus, hypertension, heart disease, CRF, etc.) with no autoimmune disorders.
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Vaccine against SARS-Cov-2 of the Pfizer/BioNTech companies
Any other vaccine authorized and administered by the Greek Ministry of Health against SARS-Cov-2
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Cohort 2
People with hematological malignancies or solid tumors in various phases of their treatment (under treatment or in remission/ follow-up).
This cohort may include patients with smoldering multiple myeloma (n=50), multiple myeloma (n=140), chronic lymphocytic leukemia (with or without hypoglobulinemia) (n=50), lymphoma (n=80), AL amyloidosis (n=30), patients who receive PARP (n=30), CDK4/6 (n=30), or immune checkpoint inhibitors (n=40), and patients under therapy with Androgen Receptor Targeted Agents (n=50).
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Vaccine against SARS-Cov-2 of the Pfizer/BioNTech companies
Any other vaccine authorized and administered by the Greek Ministry of Health against SARS-Cov-2
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Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Day 50 (28 days after the second dose of the vaccine)
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Primary endpoint of the study is the development of neutralizing antibodies against SARS-CoV-2 on Day 50 28 days after the second dose of the vaccine) in the study populations
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Day 50 (28 days after the second dose of the vaccine)
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Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Day 1
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Development of neutralizing antibodies against SARS-CoV-2 on day 1 (before the first dose of the vaccine)
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Day 1
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Day 8
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Development of neutralizing antibodies against SARS-CoV-2 on day 8
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Day 8
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Day 22
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Development of neutralizing antibodies against SARS-CoV-2 on day 22 (before the second dose of the vaccine)
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Day 22
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Day 36
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Development of neutralizing antibodies against SARS-CoV-2 on day 36
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Day 36
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Month 3
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Development of neutralizing antibodies against SARS-CoV-2 at 3 months post the second dose of the vaccine
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Month 3
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Month 6
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Development of neutralizing antibodies against SARS-CoV-2 at 6 months post the second dose of the vaccine
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Month 6
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Month 9
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Development of neutralizing antibodies against SARS-CoV-2 at 9 months post the second dose of the vaccine
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Month 9
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Month 12
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Development of neutralizing antibodies against SARS-CoV-2 at 12 months post the second dose of the vaccine
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Month 12
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Neutralizing antibodies against SARS-CoV-2
Časové okno: Month 18
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Development of neutralizing antibodies against SARS-CoV-2 at 18 months post the second dose of the vaccine
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Month 18
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Day 1
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Development of anti-S-RBD antibodies against SARS-CoV-2 on day 1 (before the first dose of the vaccine)
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Day 1
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Day 8
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Development of anti-S-RBD antibodies against SARS-CoV-2 on day 8
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Day 8
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Day 22
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Development of anti-S-RBD antibodies against SARS-CoV-2 on day 22 (before the second dose of the vaccine)
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Day 22
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Day 36
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Development of anti-S-RBD antibodies against SARS-CoV-2 on day 36
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Day 36
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Day 50
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Development of anti-S-RBD antibodies against SARS-CoV-2 on day 50
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Day 50
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Month 3
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Development of anti-S-RBD antibodies against SARS-CoV-2 at 3 months post the second dose of the vaccine
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Month 3
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Month 6
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Development of anti-S-RBD antibodies against SARS-CoV-2 at 6 months post the second dose of the vaccine
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Month 6
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Month 9
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Development of anti-S-RBD antibodies against SARS-CoV-2 at 9 months post the second dose of the vaccine
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Month 9
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Month 12
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Development of anti-S-RBD antibodies against SARS-CoV-2 at 12 months post the second dose of the vaccine
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Month 12
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Development of anti-S-RBD antibodies against SARS-CoV-2
Časové okno: Month 18
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Development of anti-S-RBD antibodies against SARS-CoV-2 at 18 months post the second dose of the vaccine
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Month 18
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Number of memory B-cells against SARS-CoV-2
Časové okno: Day 1
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According to antibody responses on day 1
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Day 1
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Number of memory B-cells against SARS-CoV-2
Časové okno: Day 8
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According to antibody responses on day 8
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Day 8
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Number of memory B-cells against SARS-CoV-2
Časové okno: Day 22
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According to antibody responses on day 22 (before the second dose of the vaccine)
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Day 22
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Number of memory B-cells against SARS-CoV-2
Časové okno: Day 36
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According to antibody responses on day 36
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Day 36
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Number of memory B-cells against SARS-CoV-2
Časové okno: Day 50
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According to antibody responses on day 50
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Day 50
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Number of memory B-cells against SARS-CoV-2
Časové okno: Month 3
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According to antibody responses at 3 months post the second dose of the vaccine
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Month 3
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Number of memory B-cells against SARS-CoV-2
Časové okno: Month 6
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According to antibody responses at 6 months post the second dose of the vaccine
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Month 6
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Number of memory B-cells against SARS-CoV-2
Časové okno: Month 9
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According to antibody responses at 9 months post the second dose of the vaccine
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Month 9
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Number of memory B-cells against SARS-CoV-2
Časové okno: Month 12
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According to antibody responses at 12 months post the second dose of the vaccine
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Month 12
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Number of memory B-cells against SARS-CoV-2
Časové okno: Month 18
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According to antibody responses at 18 months post the second dose of the vaccine
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Month 18
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Number of memory T-cells against SARS-CoV-2
Časové okno: Day 1
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According to antibody responses on day 1
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Day 1
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Number of memory T-cells against SARS-CoV-2
Časové okno: Day 8
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According to antibody responses on day 8
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Day 8
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Number of memory T-cells against SARS-CoV-2
Časové okno: Day 22
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According to antibody responses on day 22 (before the second dose of the vaccine)
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Day 22
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Number of memory T-cells against SARS-CoV-2
Časové okno: Day 36
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According to antibody responses on day 36
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Day 36
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Number of memory T-cells against SARS-CoV-2
Časové okno: Day 50
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According to antibody responses on day 50
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Day 50
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Number of memory T-cells against SARS-CoV-2
Časové okno: Month 3
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According to antibody responses at 3 months post the second dose of the vaccine
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Month 3
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Number of memory T-cells against SARS-CoV-2
Časové okno: Month 6
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According to antibody responses at 6 months post the second dose of the vaccine
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Month 6
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Number of memory T-cells against SARS-CoV-2
Časové okno: Month 9
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According to antibody responses at 9 months post the second dose of the vaccine
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Month 9
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Number of memory T-cells against SARS-CoV-2
Časové okno: Month 12
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According to antibody responses at 12 months post the second dose of the vaccine
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Month 12
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Number of memory T-cells against SARS-CoV-2
Časové okno: Month 18
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According to antibody responses at 18 months post the second dose of the vaccine
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Month 18
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Number of monocytes (CD14+, CD16+)
Časové okno: Day 1
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According to antibody responses on day 1
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Day 1
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Number of monocytes (CD14+, CD16+)
Časové okno: Day 8
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According to antibody responses on day 8
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Day 8
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Number of monocytes (CD14+, CD16+)
Časové okno: Day 22
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According to antibody responses on day 22 (before the second dose of the vaccine)
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Day 22
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Number of monocytes (CD14+, CD16+)
Časové okno: Day 36
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According to antibody responses on day 36
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Day 36
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Number of monocytes (CD14+, CD16+)
Časové okno: Day 50
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According to antibody responses on day 50
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Day 50
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Number of monocytes (CD14+, CD16+)
Časové okno: Month 3
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According to antibody responses at 3 months post the second dose of the vaccine
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Month 3
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Number of monocytes (CD14+, CD16+)
Časové okno: Month 6
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According to antibody responses at 6 months post the second dose of the vaccine
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Month 6
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Number of monocytes (CD14+, CD16+)
Časové okno: Month 9
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According to antibody responses at 9 months post the second dose of the vaccine
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Month 9
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Number of monocytes (CD14+, CD16+)
Časové okno: Month 12
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According to antibody responses at 12 months post the second dose of the vaccine
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Month 12
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Number of monocytes (CD14+, CD16+)
Časové okno: Month 18
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According to antibody responses at 18 months post the second dose of the vaccine
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Month 18
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Day 1
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Inflammatory cytokines measurements on day 1 (before the first dose of the vaccine)
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Day 1
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Day 8
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Inflammatory cytokines measurements on day 8
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Day 8
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Day 22
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Inflammatory cytokines measurements on day 22 (before the second dose of the vaccine)
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Day 22
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Day 23
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Inflammatory cytokines measurements on day 23
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Day 23
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Day 36
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Inflammatory cytokines measurements on day 36
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Day 36
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Day 50
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Inflammatory cytokines measurements on day 50
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Day 50
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Month 3
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Inflammatory cytokines measurements at 3 months post the second dose of the vaccine
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Month 3
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Month 6
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Inflammatory cytokines measurements at 6 months post the second dose of the vaccine
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Month 6
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Month 9
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Inflammatory cytokines measurements at 9 months post the second dose of the vaccine
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Month 9
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Month 12
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Inflammatory cytokines measurements at 12 months post the second dose of the vaccine
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Month 12
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Interleukin 6 (IL-6), Interleukin 3 (IL-3), Interleukin 1b (IL-1b) levels
Časové okno: Month 18
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Inflammatory cytokines measurements at 18 months post the second dose of the vaccine
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Month 18
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TNF-a levels
Časové okno: Day 1
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Inflammatory cytokines measurements on day 1 (before the first dose of the vaccine)
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Day 1
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TNF-a levels
Časové okno: Day 8
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Inflammatory cytokines measurements on day 8
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Day 8
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TNF-a levels
Časové okno: Day 22
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Inflammatory cytokines measurements on day 22 (before the second dose of the vaccine)
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Day 22
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TNF-a levels
Časové okno: Day 23
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Inflammatory cytokines measurements on day 23
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Day 23
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TNF-a levels
Časové okno: Day 36
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Inflammatory cytokines measurements on day 36
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Day 36
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TNF-a levels
Časové okno: Day 50
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Inflammatory cytokines measurements on day 50
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Day 50
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TNF-a levels
Časové okno: Month 3
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Inflammatory cytokines measurements at 3 months post the second dose of the vaccine
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Month 3
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TNF-a levels
Časové okno: Month 6
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Inflammatory cytokines measurements at 6 months post the second dose of the vaccine
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Month 6
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TNF-a levels
Časové okno: Month 9
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Inflammatory cytokines measurements at 9 months post the second dose of the vaccine
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Month 9
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TNF-a levels
Časové okno: Month 12
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Inflammatory cytokines measurements at 12 months post the second dose of the vaccine
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Month 12
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TNF-a levels
Časové okno: Month 18
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Inflammatory cytokines measurements at 18 months post the second dose of the vaccine
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Month 18
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CRP levels
Časové okno: Day 1
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CRP blood level measurements on day 1 (before the first dose of the vaccine)
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Day 1
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CRP levels
Časové okno: Day 8
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CRP blood level measurements on day 8
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Day 8
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CRP levels
Časové okno: Day 22
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CRP blood level measurements on day 22 (before the second dose of the vaccine)
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Day 22
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CRP levels
Časové okno: Day 23
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CRP blood level measurements on day 23
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Day 23
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CRP levels
Časové okno: Day 36
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CRP blood level measurements on day 36
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Day 36
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CRP levels
Časové okno: Day 50
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CRP blood level measurements on day 50
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Day 50
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CRP levels
Časové okno: Month 3
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Inflammatory cytokines measurements at 3 months post the second dose of the vaccine
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Month 3
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CRP levels
Časové okno: Month 6
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Inflammatory cytokines measurements at 6 months post the second dose of the vaccine
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Month 6
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CRP levels
Časové okno: Month 9
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Inflammatory cytokines measurements at 9 months post the second dose of the vaccine
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Month 9
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CRP levels
Časové okno: Month 12
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Inflammatory cytokines measurements at 12 months post the second dose of the vaccine
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Month 12
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CRP levels
Časové okno: Month 18
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Inflammatory cytokines measurements at 18 months post the second dose of the vaccine
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Month 18
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Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Vyšetřovatelé
- Vrchní vyšetřovatel: Evangelos Terpos, National and Kapodistrian University of Athens
Publikace a užitečné odkazy
Osoba odpovědná za zadávání informací o studiu tyto publikace poskytuje dobrovolně. Mohou se týkat čehokoli, co souvisí se studiem.
Obecné publikace
- Dagla I, Iliou A, Benaki D, Gikas E, Mikros E, Bagratuni T, Kastritis E, Dimopoulos MA, Terpos E, Tsarbopoulos A. Plasma Metabolomic Alterations Induced by COVID-19 Vaccination Reveal Putative Biomarkers Reflecting the Immune Response. Cells. 2022 Apr 6;11(7):1241. doi: 10.3390/cells11071241.
- Gavriatopoulou M, Terpos E, Ntanasis-Stathopoulos I, Briasoulis A, Gumeni S, Malandrakis P, Fotiou D, Migkou M, Theodorakakou F, Eleutherakis-Papaiakovou E, Kanellias N, Kastritis E, Trougakos IP, Dimopoulos MA. Poor neutralizing antibody responses in 106 patients with WM after vaccination against SARS-CoV-2: a prospective study. Blood Adv. 2021 Nov 9;5(21):4398-4405. doi: 10.1182/bloodadvances.2021005444.
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia (Aktuální)
4. ledna 2021
Primární dokončení (Očekávaný)
1. srpna 2022
Dokončení studie (Očekávaný)
1. prosince 2022
Termíny zápisu do studia
První předloženo
3. února 2021
První předloženo, které splnilo kritéria kontroly kvality
5. února 2021
První zveřejněno (Aktuální)
8. února 2021
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
11. dubna 2022
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
8. dubna 2022
Naposledy ověřeno
1. dubna 2022
Více informací
Termíny související s touto studií
Klíčová slova
Další relevantní podmínky MeSH
- Patologické procesy
- Koronavirové infekce
- Infekce Coronaviridae
- Infekce Nidovirales
- RNA virové infekce
- Virová onemocnění
- Infekce
- Infekce dýchacích cest
- Nemoci dýchacích cest
- Novotvary
- Pneumonie, virová
- Zápal plic
- Plicní onemocnění
- Novotvary podle místa
- Atributy nemoci
- Hematologická onemocnění
- COVID-19
- Hematologické novotvary
- Chronické onemocnění
Další identifikační čísla studie
- 900/24-12-2020
Plán pro data jednotlivých účastníků (IPD)
Plánujete sdílet data jednotlivých účastníků (IPD)?
NE
Popis plánu IPD
At the end of the study, the results will be announced in medical conferences or medical journals.
Informace o lécích a zařízeních, studijní dokumenty
Studuje lékový produkt regulovaný americkým FDA
Ano
Studuje produkt zařízení regulovaný americkým úřadem FDA
Ne
produkt vyrobený a vyvážený z USA
Ne
Tyto informace byly beze změn načteny přímo z webu clinicaltrials.gov. Máte-li jakékoli požadavky na změnu, odstranění nebo aktualizaci podrobností studie, kontaktujte prosím register@clinicaltrials.gov. Jakmile bude změna implementována na clinicaltrials.gov, bude automaticky aktualizována i na našem webu .
Klinické studie na COVID-19
-
PfizerAktivní, ne náborCOVID-19 | Coronavirus Disease 2019 (COVID-19) | Infekce covid-19 | Vakcíny na covid-19 | Infekce SARS-CoV-2, COVID19 | Očkování proti COVID-19 | Infekce SARS-CoV-2, COVID-19 | COVID-19 (koronavirová nemoc 2019) | Infekce COVID-19 SARS-CoV-2Spojené státy
-
Shanghai Public Health Clinical CenterZatím nenabíráme
-
Duke UniversityNational Institute on Minority Health and Health Disparities (NIMHD)Dokončeno
-
PfizerNáborNemoci dýchacích cest | COVID-19 | Zápal plic | Plicní onemocnění | Koronavirové onemocnění 2019 | Coronavirus Disease 2019 (COVID-19) | Infekce covid-19 | Infekce horních cest dýchacích | Infekce dýchacích cest | COVID-19 (koronavirová nemoc 2019) | Infekce COVID-19 SARS-CoV-2Belgie
-
Eggensberger OHGBavarian Health and Food Safety Authority (LGL)NáborStav po COVID-19 | Po COVID-19 | Po syndromu COVID-19 | Dlouhý syndrom COVID-19 | Stav po COVID-19 (PCC)Německo
-
University of Roma La SapienzaQueen Mary University of London; Università degli studi di Roma Foro Italico; Bios Prevention SrlDokončenoPo akutních následcích COVID-19 | Stav po COVID-19 | Long-COVID | Chronický syndrom COVID-19Itálie
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ModeX Therapeutics, An OPKO Health CompanyNáborStudie hodnotící MDX2301 u zdravých dospělých a dospělých s vyšším rizikem těžkého průběhu COVID-19.COVID 19 | COVID-19 (Prevence)Spojené státy
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Lawson Research Institute of St. Joseph'sCanadian Institutes of Health Research (CIHR); Western University, CanadaNáborÚnava | Post-COVID-19 syndrom | Stav po COVID-19 | Post-COVID syndrom | Dlouhý COVID-19 | Long-COVID | Stav po COVIDKanada
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Yang I. PachankisAktivní, ne náborRespirační infekce COVID-19 | Stresový syndrom COVID-19 | Nežádoucí reakce vakcíny COVID-19 | Tromboembolismus spojený s COVID-19 | Syndrom post-intenzivní péče COVID-19 | Cévní mozková příhoda spojená s COVID-19Čína
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Indonesia UniversityNáborPost-COVID-19 syndrom | Dlouhý COVID | Stav po COVID-19 | Post-COVID syndrom | Dlouhý COVID-19Indonésie
Klinické studie na BNT162b2
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PfizerDokončenoCOVID-19 | SARS-CoV-2Korejská republika
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BioNTech SEDokončenoCOVID-19 | Infekce SARS-CoV-2 | SARS-CoV-2 Akutní respirační onemocnění | SARS (nemoc)Spojené státy, Německo, Krocan, Jižní Afrika
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BioNTech SEPfizerDokončeno
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BioNTech SEPfizerDokončenoCOVID-19 | Infekce SARS-CoV-2Spojené státy, Brazílie, Jižní Afrika, Německo, Izrael
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PfizerDokončeno
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The University of Hong KongNáborImunokompromitovaní pacienti | Intradermální vakcína proti Covid-19 | Imunita a bezpečnost | Randomizovaná zkouškaHongkong
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Universiteit AntwerpenDokončenoCOVID-19 | Koronavirové onemocnění 2019Belgie
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Murdoch Childrens Research InstituteCoalition for Epidemic Preparedness Innovations; The Peter Doherty Institute...Staženo
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BioNTech SEPfizerDokončenoCOVID-19 | Infekce SARS-CoV-2Spojené státy
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Shaare Zedek Medical CenterDokončenoCOVID-19 | Poranění myokardu | Nežádoucí reakce vakcínyIzrael