Sex-difference in Response to Resistance Exercise and Training (WOMENRESIST S1)
2. července 2026 aktualizováno: Université Catholique de Louvain
Sex-Difference in Response to Resistance Exercise and Training
Given the importance of muscular strength for athletic performance as well as for daily activities in the general population-including clinical populations-and the lack of data in both men and women, the aim of this study is to compare neuromuscular, intramuscular, and systemic adaptations in men and women in response to both acute and chronic resistance exercise.
Specifically, the investigators will test the hypotheses that:
the neuromuscular response to resistance exercise, including corticospinal excitability and motor unit activation patterns, differs between men and women; the hormonal response and exosome release following resistance exercise are reduced in women compared to men.
Participants (n = 15 per group) will follow a supervised resistance training program for 8 weeks. Neuromuscular function of the knee extensor muscles, body composition, intramuscular adaptations, as well as blood profiles (hormonal and metabolic) and exosomes will be assessed before and after a single resistance exercise session and after the training period. This protocol will allow determination of both the acute and long-term effects of resistance exercise.
Women's participation in sports is increasing, yet research in this area remains very limited. This project aims to better understand the mechanisms by which resistance training-a non-pharmacological and low-cost strategy-may induce different adaptations in men and women, and, where appropriate, to contribute to the development of sex-specific recommendations to maximize the health benefits of resistance training.
Přehled studie
Postavení
Zápis na pozvánku
Podmínky
Intervence / Léčba
- Přístroj: Resistance exercise on a leg extension machine
- Přístroj: Resistance training on a leg extension machine
- Postup: Blood samples
- Postup: Vastus lateralis biopsy
- Diagnostický test: Body composition analysis
- Diagnostický test: One repetition maximum (1-RM)
- Diagnostický test: Muscle thickness of the vastus lateralis
Typ studie
Intervenční
Zápis (Odhadovaný)
30
Fáze
- Nelze použít
Kontakty a umístění
Tato část poskytuje kontaktní údaje pro ty, kteří studii provádějí, a informace o tom, kde se tato studie provádí.
Studijní místa
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Louvain-la-Neuve, Belgie, 1348
- Faculté des sciences de la motricité, Pl. Pierre de Coubertin 1
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Kritéria účasti
Výzkumníci hledají lidi, kteří odpovídají určitému popisu, kterému se říká kritéria způsobilosti. Některé příklady těchto kritérií jsou celkový zdravotní stav osoby nebo předchozí léčba.
Kritéria způsobilosti
Věk způsobilý ke studiu
- Dospělý
Přijímá zdravé dobrovolníky
Ano
Popis
Inclusion Criteria:
- Men and women aged between 18 and 40 years;
- eumenorrheic women or under contraceptive (hormonal and non-hormonal).
Exclusion Criteria:
- Regular resistance exercise (≥2x/week);
- Any contraindication to exercise;
- Protein/creatine supplement intake;
- Pregnancy;
- Epilepsy;
- Head implant.
Studijní plán
Tato část poskytuje podrobnosti o studijním plánu, včetně toho, jak je studie navržena a co studie měří.
Jak je studie koncipována?
Detaily designu
- Primární účel: Základní věda
- Přidělení: Nerandomizované
- Intervenční model: Paralelní přiřazení
- Maskování: Žádné (otevřený štítek)
Zbraně a zásahy
Skupina účastníků / Arm |
Intervence / Léčba |
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Experimentální: Men
Male participants performing a supervised 8-week resistance training program.
Neuromuscular, intramuscular, and systemic responses to both acute and chronic resistance exercise will be assessed.
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Supervised resistance exercise consisting exclusively of knee extension exercise on a leg extension machine.
Acute exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
Supervised resistance training consisting exclusively of knee extension exercise on a leg extension machine.
Chronic exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
The program was carried out over 8 weeks (3x/week).
Blood samples were taken from the antecubital vein before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Biopsy were taken in the vastus lateralis before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Body composition analysis using dual-energy X-ray absorptiometry (DXA) before and after the chronic resistance training period.
One repetition maximum (1-RM) assessment before, after 4 weeks of training and at the end the chronic resistance training period.
Muscle thickness of the vastus lateralis assessed by ultrasonography before and after the chronic resistance training period.
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Experimentální: Women
Female participants performing a supervised 8-week resistance training program.
Neuromuscular, intramuscular, and systemic responses to both acute and chronic resistance exercise will be assessed.
|
Supervised resistance exercise consisting exclusively of knee extension exercise on a leg extension machine.
Acute exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
Supervised resistance training consisting exclusively of knee extension exercise on a leg extension machine.
Chronic exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
The program was carried out over 8 weeks (3x/week).
Blood samples were taken from the antecubital vein before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Biopsy were taken in the vastus lateralis before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Body composition analysis using dual-energy X-ray absorptiometry (DXA) before and after the chronic resistance training period.
One repetition maximum (1-RM) assessment before, after 4 weeks of training and at the end the chronic resistance training period.
Muscle thickness of the vastus lateralis assessed by ultrasonography before and after the chronic resistance training period.
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Co je měření studie?
Primární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Sex differences in protein expression of muscle mass regulation pathways assessed by western blot
Časové okno: Throughout the entire study, during approximately 11 months
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Assessment of protein of expression muscle mass regulation pathways after acute exercise and chronic exercise using western blot (ratio of target protein to reference protein)
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Throughout the entire study, during approximately 11 months
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Sex differences in mRNA levels in muscle mass regulation pathways assessed by RT-qPCR
Časové okno: Throughout the entire study, during approximately 11 months
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Assessment of mRNA levels of muscle mass regulation pathways after acute exercise and chronic exercise usin RT-qPCR (fold change).
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Throughout the entire study, during approximately 11 months
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Sex differences in metabolic status assessed by blood biomarkers
Časové okno: Throughout the entire study, during approximately 11 months
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Assessment of metabolic blood parameters before and after acute exercise and chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in hormonal status assessed by blood biomarkers
Časové okno: Throughout the entire study, during approximately 11 months
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Assessment of hormonal blood parameters before and after acute exercise and chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in extracellular vesicles regulation assessed by nanoparticle tracking analysis
Časové okno: Throughout the entire study, during approximately 11 months
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Assessment of the concentration and size of circulating extracellular vesicles after acute exercise and chronic exercise using nanoparticle tracking analysis.
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Throughout the entire study, during approximately 11 months
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Sex differences in extracellular vesicles regulation assessed by proteomic analysis
Časové okno: Throughout the entire study, during approximately 11 months
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Assessment of protein expression of circulating extracellular vesicles after acute exercise and chronic exercise using proteomic analysis
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Throughout the entire study, during approximately 11 months
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Sekundární výstupní opatření
Měření výsledku |
Popis opatření |
Časové okno |
|---|---|---|
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Sex differences in body composition assessed by dual-energy X-ray absorptiometry (DXA)
Časové okno: Throughout the entire study, during approximately 11 months
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Comparison of fat mass and lean mass between men and women before and after the chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in muscle thickness of the vastus lateralis assessed by ultrasonography
Časové okno: Throughout the entire study, during approximately 11 months
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Comparison of vastus lateralis muscle thickness between men and women before and after the chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in strength evolution assessed by one-repetition maximum (1-RM)
Časové okno: Throughout the entire study, during approximately 11 months
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Comparison of maximal strength evolution between men and women before and after the chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Spolupracovníci a vyšetřovatelé
Zde najdete lidi a organizace zapojené do této studie.
Sponzor
Vyšetřovatelé
- Vrchní vyšetřovatel: Sylvie Copine, Université Catholique de Louvain
Termíny studijních záznamů
Tato data sledují průběh záznamů studie a předkládání souhrnných výsledků na ClinicalTrials.gov. Záznamy ze studií a hlášené výsledky jsou před zveřejněním na veřejné webové stránce přezkoumány Národní lékařskou knihovnou (NLM), aby se ujistily, že splňují specifické standardy kontroly kvality.
Hlavní termíny studia
Začátek studia (Aktuální)
2. února 2026
Primární dokončení (Odhadovaný)
31. prosince 2026
Dokončení studie (Odhadovaný)
31. prosince 2026
Termíny zápisu do studia
První předloženo
11. června 2026
První předloženo, které splnilo kritéria kontroly kvality
2. července 2026
První zveřejněno (Aktuální)
9. července 2026
Aktualizace studijních záznamů
Poslední zveřejněná aktualizace (Aktuální)
9. července 2026
Odeslaná poslední aktualizace, která splnila kritéria kontroly kvality
2. července 2026
Naposledy ověřeno
1. července 2026
Více informací
Termíny související s touto studií
Klíčová slova
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