Sex-difference in Response to Resistance Exercise and Training (WOMENRESIST S1)
2 luglio 2026 aggiornato da: Université Catholique de Louvain
Sex-Difference in Response to Resistance Exercise and Training
Given the importance of muscular strength for athletic performance as well as for daily activities in the general population-including clinical populations-and the lack of data in both men and women, the aim of this study is to compare neuromuscular, intramuscular, and systemic adaptations in men and women in response to both acute and chronic resistance exercise.
Specifically, the investigators will test the hypotheses that:
the neuromuscular response to resistance exercise, including corticospinal excitability and motor unit activation patterns, differs between men and women; the hormonal response and exosome release following resistance exercise are reduced in women compared to men.
Participants (n = 15 per group) will follow a supervised resistance training program for 8 weeks. Neuromuscular function of the knee extensor muscles, body composition, intramuscular adaptations, as well as blood profiles (hormonal and metabolic) and exosomes will be assessed before and after a single resistance exercise session and after the training period. This protocol will allow determination of both the acute and long-term effects of resistance exercise.
Women's participation in sports is increasing, yet research in this area remains very limited. This project aims to better understand the mechanisms by which resistance training-a non-pharmacological and low-cost strategy-may induce different adaptations in men and women, and, where appropriate, to contribute to the development of sex-specific recommendations to maximize the health benefits of resistance training.
Panoramica dello studio
Stato
Iscrizione su invito
Condizioni
Intervento / Trattamento
- Dispositivo: Resistance exercise on a leg extension machine
- Dispositivo: Resistance training on a leg extension machine
- Procedura: Blood samples
- Procedura: Vastus lateralis biopsy
- Test diagnostico: Body composition analysis
- Test diagnostico: One repetition maximum (1-RM)
- Test diagnostico: Muscle thickness of the vastus lateralis
Tipo di studio
Interventistico
Iscrizione (Stimato)
30
Fase
- Non applicabile
Contatti e Sedi
Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.
Luoghi di studio
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Louvain-la-Neuve, Belgio, 1348
- Faculté des sciences de la motricité, Pl. Pierre de Coubertin 1
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Criteri di partecipazione
I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.
Criteri di ammissibilità
Età idonea allo studio
- Adulto
Accetta volontari sani
Sì
Descrizione
Inclusion Criteria:
- Men and women aged between 18 and 40 years;
- eumenorrheic women or under contraceptive (hormonal and non-hormonal).
Exclusion Criteria:
- Regular resistance exercise (≥2x/week);
- Any contraindication to exercise;
- Protein/creatine supplement intake;
- Pregnancy;
- Epilepsy;
- Head implant.
Piano di studio
Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.
Come è strutturato lo studio?
Dettagli di progettazione
- Scopo principale: Scienza basilare
- Assegnazione: Non randomizzato
- Modello interventistico: Assegnazione parallela
- Mascheramento: Nessuno (etichetta aperta)
Armi e interventi
Gruppo di partecipanti / Arm |
Intervento / Trattamento |
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Sperimentale: Men
Male participants performing a supervised 8-week resistance training program.
Neuromuscular, intramuscular, and systemic responses to both acute and chronic resistance exercise will be assessed.
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Supervised resistance exercise consisting exclusively of knee extension exercise on a leg extension machine.
Acute exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
Supervised resistance training consisting exclusively of knee extension exercise on a leg extension machine.
Chronic exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
The program was carried out over 8 weeks (3x/week).
Blood samples were taken from the antecubital vein before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Biopsy were taken in the vastus lateralis before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Body composition analysis using dual-energy X-ray absorptiometry (DXA) before and after the chronic resistance training period.
One repetition maximum (1-RM) assessment before, after 4 weeks of training and at the end the chronic resistance training period.
Muscle thickness of the vastus lateralis assessed by ultrasonography before and after the chronic resistance training period.
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Sperimentale: Women
Female participants performing a supervised 8-week resistance training program.
Neuromuscular, intramuscular, and systemic responses to both acute and chronic resistance exercise will be assessed.
|
Supervised resistance exercise consisting exclusively of knee extension exercise on a leg extension machine.
Acute exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
Supervised resistance training consisting exclusively of knee extension exercise on a leg extension machine.
Chronic exercise included 6 sets of 10 repetitions at 80% of one-repetition maximum (1RM).
The program was carried out over 8 weeks (3x/week).
Blood samples were taken from the antecubital vein before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Biopsy were taken in the vastus lateralis before and immediately after an acute resistance exercise session, and after the chronic resistance training period.
Body composition analysis using dual-energy X-ray absorptiometry (DXA) before and after the chronic resistance training period.
One repetition maximum (1-RM) assessment before, after 4 weeks of training and at the end the chronic resistance training period.
Muscle thickness of the vastus lateralis assessed by ultrasonography before and after the chronic resistance training period.
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Cosa sta misurando lo studio?
Misure di risultato primarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Sex differences in protein expression of muscle mass regulation pathways assessed by western blot
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Assessment of protein of expression muscle mass regulation pathways after acute exercise and chronic exercise using western blot (ratio of target protein to reference protein)
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Throughout the entire study, during approximately 11 months
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Sex differences in mRNA levels in muscle mass regulation pathways assessed by RT-qPCR
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Assessment of mRNA levels of muscle mass regulation pathways after acute exercise and chronic exercise usin RT-qPCR (fold change).
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Throughout the entire study, during approximately 11 months
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Sex differences in metabolic status assessed by blood biomarkers
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Assessment of metabolic blood parameters before and after acute exercise and chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in hormonal status assessed by blood biomarkers
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Assessment of hormonal blood parameters before and after acute exercise and chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in extracellular vesicles regulation assessed by nanoparticle tracking analysis
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Assessment of the concentration and size of circulating extracellular vesicles after acute exercise and chronic exercise using nanoparticle tracking analysis.
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Throughout the entire study, during approximately 11 months
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Sex differences in extracellular vesicles regulation assessed by proteomic analysis
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Assessment of protein expression of circulating extracellular vesicles after acute exercise and chronic exercise using proteomic analysis
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Throughout the entire study, during approximately 11 months
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Misure di risultato secondarie
Misura del risultato |
Misura Descrizione |
Lasso di tempo |
|---|---|---|
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Sex differences in body composition assessed by dual-energy X-ray absorptiometry (DXA)
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Comparison of fat mass and lean mass between men and women before and after the chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in muscle thickness of the vastus lateralis assessed by ultrasonography
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Comparison of vastus lateralis muscle thickness between men and women before and after the chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Sex differences in strength evolution assessed by one-repetition maximum (1-RM)
Lasso di tempo: Throughout the entire study, during approximately 11 months
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Comparison of maximal strength evolution between men and women before and after the chronic resistance training.
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Throughout the entire study, during approximately 11 months
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Collaboratori e investigatori
Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.
Sponsor
Investigatori
- Investigatore principale: Sylvie Copine, Université Catholique de Louvain
Studiare le date dei record
Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.
Studia le date principali
Inizio studio (Effettivo)
2 febbraio 2026
Completamento primario (Stimato)
31 dicembre 2026
Completamento dello studio (Stimato)
31 dicembre 2026
Date di iscrizione allo studio
Primo inviato
11 giugno 2026
Primo inviato che soddisfa i criteri di controllo qualità
2 luglio 2026
Primo Inserito (Effettivo)
9 luglio 2026
Aggiornamenti dei record di studio
Ultimo aggiornamento pubblicato (Effettivo)
9 luglio 2026
Ultimo aggiornamento inviato che soddisfa i criteri QC
2 luglio 2026
Ultimo verificato
1 luglio 2026
Maggiori informazioni
Termini relativi a questo studio
Parole chiave
Termini MeSH pertinenti aggiuntivi
Altri numeri di identificazione dello studio
- WOMENRESIST S1
Piano per i dati dei singoli partecipanti (IPD)
Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?
NO
Informazioni su farmaci e dispositivi, documenti di studio
Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti
No
Studia un dispositivo regolamentato dalla FDA degli Stati Uniti
No
Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .