Undertrykkelse af ovariefunktion med enten Tamoxifen eller Exemestan sammenlignet med Tamoxifen alene til behandling af præmenopausale kvinder med hormonreagerende brystkræft (SOFT)
14. december 2023 opdateret af: ETOP IBCSG Partners Foundation
Et fase III-forsøg, der evaluerer rollen af ovariefunktionssuppression og rollen af exemestan som adjuverende terapier til præmenopausale kvinder med endokrin-responsiv brystkræft
RATIONALE: Østrogen kan stimulere væksten af brysttumorceller. Ovariefunktionsundertrykkelse kombineret med hormonbehandling med tamoxifen eller exemestan kan bekæmpe brystkræft ved at reducere produktionen af østrogen. Det vides endnu ikke, om undertrykkelse af ovariefunktion plus enten tamoxifen eller exemestan er mere effektivt end tamoxifen alene til at forhindre tilbagefald af hormon-responsiv brystkræft.
FORMÅL: Dette randomiserede fase III-forsøg undersøger ovariesuppression med enten tamoxifen eller exemestan for at se, hvor godt de virker sammenlignet med tamoxifen alene ved behandling af præmenopausale kvinder, der er blevet opereret for hormonresponsiv brystkræft.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Detaljeret beskrivelse
MÅL:
- Sammenlign sygdomsfri overlevelse, brystkræftfri interval, fjernt tilbagefaldsfrit interval og overordnet overlevelse for præmenopausale kvinder med endokrin-responderende brystkræft, når de behandles med tamoxifen + ovariefunktionsundertrykkelse (ved triptorelin, oophorektomi eller ovariebestråling) eller exemestan + undertrykkelse af ovariefunktion vs. tamoxifen alene. Den primære sammenligning er ovariefunktionsundertrykkelse med enten tamoxifen eller exemestan vs. tamoxifen alene.
- Sammenlign livskvaliteten, herunder sene bivirkninger af tidlig overgangsalder, for patienter behandlet med disse regimer.
OVERSIGT: Dette er en randomiseret, multicenter undersøgelse. Patienterne stratificeres efter deltagende center, forudgående adjuverende/neoadjuverende kemoterapi (ja vs nej) og antallet af positive aksillære og/eller interne brystlymfeknuder (0 vs 1 eller mere) og tilsigtet indledende metode til ovariefunktionsundertrykkelse (triptorelin vs ooforektomi) vs ovariebestråling). Behandlingsvarighed er 5 år. Patienterne følges hver 3. måned i 1 år, hver 6. måned i 5 år og derefter årligt. Livskvalitet vurderes ved baseline, hver 6. måned i 2 år og derefter årligt i 4 år.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
3066
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alberta
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Calgary, Alberta, Canada, T2N 4N2
- Tom Baker Cancer Centre
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Edmonton, Alberta, Canada, T6G 1Z2
- Cross Cancer Institute
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British Columbia
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Kelowna, British Columbia, Canada, V1Y 5L3
- BCCA-Cancer Centre for the Southern Interior
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Penticton, British Columbia, Canada, V2A 3G6
- Penticton Regional Hospital
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Surrey, British Columbia, Canada, V3V 1Z2
- BCCA-Fraser Valley Cancer Centre
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Vancouver, British Columbia, Canada, V5Z 4E6
- BCCA-Vancouver Cancer Centre
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Manitoba
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Winnipeg, Manitoba, Canada, R3E 0V9
- CancerCare Manitoba
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Newfoundland and Labrador
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St. John's, Newfoundland and Labrador, Canada, A1B 3V6
- Doctor H. Bliss Murphy Cancer Centre
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Ontario
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Hamilton, Ontario, Canada, L8V 5C2
- Juravinski Cancer Centre at Hamilton Health Sciences
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Kingston, Ontario, Canada, K7L 5P9
- Cancer Centre of Southeastern Ontario At Kingston General Hospital
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London, Ontario, Canada, N6A 4L6
- London Regional Cancer Program
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Ottawa, Ontario, Canada, K1H 8L6
- Ottawa Hospital and Cancer Center-General Campus
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Sudbury, Ontario, Canada, P3E 5J1
- Health Sciences North
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Thunder Bay, Ontario, Canada, P7B 6V4
- Thunder Bay Regional Health Science Centre
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Toronto, Ontario, Canada, M4N 3M5
- Odette Cancer Centre- Sunnybrook Health Sciences Centre
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Quebec
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Greenfield Park, Quebec, Canada, J4V 2H1
- CSSS Champlain-Charles Le Moyne
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Montreal, Quebec, Canada, H4J 1C5
- Hopital du Sacre-Coeur de Montreal
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Montreal, Quebec, Canada, H2W 1T8
- CHUM-Hotel Dieu du Montreal
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Saskatchewan
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Regina, Saskatchewan, Canada, S4T 7T1
- Allan Blair Cancer Centre
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Alabama
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Alaska
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Arizona
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Scottsdale, Arizona, Forenede Stater, 85259
- Mayo Clinic in Arizona
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California
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burlingame, California, Forenede Stater, 94010
- Mills - Peninsula Hospitals
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Castro Valley, California, Forenede Stater, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, Forenede Stater, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Concord, California, Forenede Stater, 94520
- John Muir Medical Center-Concord Campus
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Fremont, California, Forenede Stater, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Forenede Stater, 94538
- Valley Medical Oncology Consultants-Fremont
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Glendale, California, Forenede Stater, 91204
- Glendale Memorial Hospital and Health Center
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Greenbrae, California, Forenede Stater, 94904
- Marin General Hospital
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La Jolla, California, Forenede Stater, 92037
- Scripps Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Los Angeles, California, Forenede Stater, 90095
- UCLA / Jonsson Comprehensive Cancer Center
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forenede Stater, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, Forenede Stater, 94609
- Tom K Lee Inc
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Palo Alto, California, Forenede Stater, 94304
- Stanford Cancer Institute
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Pleasanton, California, Forenede Stater, 94588
- Valley Medical Oncology Consultants
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Rancho Mirage, California, Forenede Stater, 92270
- Eisenhower Medical Center
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Redding, California, Forenede Stater, 96001
- Mercy Regional Cancer Center
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forenede Stater, 94801
- Kaiser Permanente-Richmond
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Forenede Stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forenede Stater, 95825
- Kaiser Permanente - Sacramento
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Sacramento, California, Forenede Stater, 95819
- Mercy General Hospital
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Salinas, California, Forenede Stater, 93901
- Salinas Valley Memorial
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San Diego, California, Forenede Stater, 92108
- Kaiser Permanente-San Diego Mission
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San Diego, California, Forenede Stater, 92103
- University of California San Diego
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San Diego, California, Forenede Stater, 92161
- Veterans Administration-San Diego Medical Center
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San Francisco, California, Forenede Stater, 94110
- San Francisco General Hospital
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Francisco, California, Forenede Stater, 94115
- UCSF Medical Center-Mount Zion
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forenede Stater, 94577
- Kaiser Permanente San Leandro
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San Rafael, California, Forenede Stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, Forenede Stater, 95403
- Kaiser Permanente-Santa Rosa
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Santa Rosa, California, Forenede Stater, 95405
- Santa Rosa Memorial Hospital
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Walnut Creek, California, Forenede Stater, 94598
- John Muir Medical Center-Walnut Creek
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- Memorial Hospital Colorado Springs
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80204
- Denver Health Medical Center
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Denver, Colorado, Forenede Stater, 80222
- Colorado Cancer Research Program NCORP
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Denver, Colorado, Forenede Stater, 80220
- Denver Veterans Administration Medical Center
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Edwards, Colorado, Forenede Stater, 81632
- The Shaw Regional Cancer Center
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Fort Collins, Colorado, Forenede Stater, 80528
- Front Range Cancer Specialists
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Forenede Stater, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Hartford, Connecticut, Forenede Stater, 06102
- Hartford Hospital
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Norwalk, Connecticut, Forenede Stater, 06856
- Norwalk Hospital
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Norwich, Connecticut, Forenede Stater, 06360
- Eastern Connecticut Hematology and Oncology Associates
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Stamford, Connecticut, Forenede Stater, 06904
- Stamford Hospital/Bennett Cancer Center
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Torrington, Connecticut, Forenede Stater, 06790
- Charlotte Hungerford Hospital Center for Cancer Care
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Delaware
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Dover, Delaware, Forenede Stater, 19901
- Bayhealth Medical Center at Kent General
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Seaford, Delaware, Forenede Stater, 19973
- Nanticoke Memorial Hospital
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20010
- MedStar Washington Hospital Center
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Washington, District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Washington, District of Columbia, Forenede Stater, 20016
- Sibley Memorial Hospital
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Florida
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Boca Raton, Florida, Forenede Stater, 33428
- Cancer Research Network Inc
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Hollywood, Florida, Forenede Stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Jacksonville, Florida, Forenede Stater, 32207
- Baptist MD Anderson Cancer Center
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Jacksonville, Florida, Forenede Stater, 32224-9980
- Mayo Clinic in Florida
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Jupiter, Florida, Forenede Stater, 33458
- Jupiter Medical Center
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Sarasota, Florida, Forenede Stater, 34236
- Florida Cancer Specialists - Sarasota Downtown
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Georgia
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Atlanta, Georgia, Forenede Stater, 30309
- Piedmont Hospital
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Atlanta, Georgia, Forenede Stater, 30342
- Saint Joseph's Hospital of Atlanta
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Atlanta, Georgia, Forenede Stater, 30342
- Atlanta Regional CCOP
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Augusta, Georgia, Forenede Stater, 30901
- Augusta Oncology Associates PC-Saint Sebastian
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Austell, Georgia, Forenede Stater, 30106
- Well Star Cobb Hospital
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Columbus, Georgia, Forenede Stater, 31904
- John B Amos Cancer Center
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Decatur, Georgia, Forenede Stater, 30033
- Dekalb Medical Center
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Lawrenceville, Georgia, Forenede Stater, 30045
- Gwinnett Medical Center
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Marietta, Georgia, Forenede Stater, 30060
- WellStar Kennestone Hospital
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Riverdale, Georgia, Forenede Stater, 30274
- Southern Regional Medical Center
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Rome, Georgia, Forenede Stater, 30165
- Harbin Clinic Medical Oncology and Clinical Research
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Forenede Stater, 31404
- Memorial University Medical Center
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Hawaii
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96859
- Tripler Army Medical Center
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Illinois
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Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Graham Hospital Association
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Carthage, Illinois, Forenede Stater, 62321
- Memorial Hospital
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Chicago, Illinois, Forenede Stater, 60612
- Rush University Medical Center
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Chicago, Illinois, Forenede Stater, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forenede Stater, 60640
- Weiss Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Heartland Cancer Research NCORP
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Eureka, Illinois, Forenede Stater, 61530
- Eureka Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Galesburg, Illinois, Forenede Stater, 61401
- Galesburg Cottage Hospital
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
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Havana, Illinois, Forenede Stater, 62644
- Mason District Hospital
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Hopedale, Illinois, Forenede Stater, 61747
- Hopedale Medical Complex - Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Kewanee Hospital
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Macomb, Illinois, Forenede Stater, 61455
- Mcdonough District Hospital
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Naperville, Illinois, Forenede Stater, 60540
- Edward Hospital/Cancer Center
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Normal, Illinois, Forenede Stater, 61761
- Community Cancer Center Foundation
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Normal, Illinois, Forenede Stater, 61761
- Bromenn Regional Medical Center
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Ottawa, Illinois, Forenede Stater, 61350
- Ottawa Regional Hospital and Healthcare Center
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Pekin, Illinois, Forenede Stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Pekin, Illinois, Forenede Stater, 61554
- Pekin Hospital
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Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Forenede Stater, 61614
- Proctor Hospital
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Peoria, Illinois, Forenede Stater, 61603
- Methodist Medical Center of Illinois
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Peru, Illinois, Forenede Stater, 61354
- Illinois Valley Hospital
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Princeton, Illinois, Forenede Stater, 61356
- Perry Memorial Hospital
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Rockford, Illinois, Forenede Stater, 61108
- OSF Saint Anthony Medical Center
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Rushville, Illinois, Forenede Stater, 62681
- Sarah Culbertson Memorial Hospital
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Spring Valley, Illinois, Forenede Stater, 61362
- Saint Margaret's Hospital
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Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
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Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
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Indiana
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Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
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Fort Wayne, Indiana, Forenede Stater, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
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Indianapolis, Indiana, Forenede Stater, 46202
- Sidney and Lois Eskenazi Hospital
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Indianapolis, Indiana, Forenede Stater, 46260
- Saint Vincent Hospital and Health Care Center
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Indianapolis, Indiana, Forenede Stater, 46219
- Community Hospital East
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Indianapolis, Indiana, Forenede Stater, 46256
- Community Regional Cancer Care-North
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La Porte, Indiana, Forenede Stater, 46350
- IU Health La Porte Hospital
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Lafayette, Indiana, Forenede Stater, 47904
- IU Health Arnett Cancer Care
-
Lafayette, Indiana, Forenede Stater, 47905
- Horizon Oncology Center
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Mishawaka, Indiana, Forenede Stater, 46545
- Saint Joseph Regional Medical Center - Mishawaka
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South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
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South Bend, Indiana, Forenede Stater, 46628
- Northern Indiana Cancer Research Consortium
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Iowa
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Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic PC-William R Bliss Cancer Center
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Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
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Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Saint Luke's Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Physicians' Clinic of Iowa PC
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Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
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Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
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Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
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Des Moines, Iowa, Forenede Stater, 50309
- Iowa-Wide Oncology Research Coalition NCORP
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Des Moines, Iowa, Forenede Stater, 50314
- Medical Oncology and Hematology Associates-Laurel
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Des Moines, Iowa, Forenede Stater, 50307
- Mercy Capitol
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Dubuque, Iowa, Forenede Stater, 52001
- Finley Hospital
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Dubuque, Iowa, Forenede Stater, 52001
- Medical Associates Clinic PC
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Mason City, Iowa, Forenede Stater, 50401
- Mercy Medical Center - North Iowa
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Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Regional Cancer Center
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Kansas
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Arkansas City, Kansas, Forenede Stater, 67005
- Memorial Hospital of Arkansas City
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Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
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Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
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El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
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Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
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Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
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Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
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McPherson, Kansas, Forenede Stater, 67460
- Cancer Center of Kansas - McPherson
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Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
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Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
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Topeka, Kansas, Forenede Stater, 66606
- Saint Francis Hospital and Medical Center - Topeka
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Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
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Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
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Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
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Wichita, Kansas, Forenede Stater, 67214
- Wichita NCI Community Oncology Research Program
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Main Office
-
Wichita, Kansas, Forenede Stater, 67214
- Via Christi Regional Medical Center
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
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Louisiana
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Shreveport, Louisiana, Forenede Stater, 71103
- Louisiana State University Health Sciences Center Shreveport
-
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Maine
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Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Portland, Maine, Forenede Stater, 04101
- Mercy Hospital
-
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Maryland
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Annapolis, Maryland, Forenede Stater, 21401
- Anne Arundel Medical Center
-
Baltimore, Maryland, Forenede Stater, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Forenede Stater, 21225
- Harbor Hospital Center
-
Bethesda, Maryland, Forenede Stater, 20814
- Suburban Hospital
-
Elkton, Maryland, Forenede Stater, 21921
- Union Hospital of Cecil County
-
Largo, Maryland, Forenede Stater, 20774
- Kaiser Permanente - Largo Medical Center
-
Lutherville, Maryland, Forenede Stater, 21093
- Kaiser Permanente - Towson Medical Center
-
Rockville, Maryland, Forenede Stater, 20850
- Kaiser Permanente - Shady Grove Medical Center
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Massachusetts
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Boston, Massachusetts, Forenede Stater, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Forenede Stater, 02115
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Forenede Stater, 02115
- Brigham and Women's Hospital
-
Boston, Massachusetts, Forenede Stater, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Forenede Stater, 02114
- Massachusetts General Hospital Cancer Center
-
Boston, Massachusetts, Forenede Stater, 02130
- Brigham and Women's Faulkner Hospital
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Concord, Massachusetts, Forenede Stater, 01742
- Emerson Hospital/MGH Cancer Center
-
Danvers, Massachusetts, Forenede Stater, 01923
- Mass General/North Shore Cancer Center
-
Framingham, Massachusetts, Forenede Stater, 01702
- MetroWest Medical Center-Framingham Union Hospital
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Lowell, Massachusetts, Forenede Stater, 01854
- Lowell General Hospital
-
Newton, Massachusetts, Forenede Stater, 02462
- Newton-Wellesley Hospital
-
South Weymouth, Massachusetts, Forenede Stater, 02190
- South Shore Hospital
-
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Michigan
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Adrian, Michigan, Forenede Stater, 49221
- Bixby Medical Center
-
Adrian, Michigan, Forenede Stater, 49221
- Hickman Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106-0995
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, Forenede Stater, 48109
- University of Michigan Comprehensive Cancer Center
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Michigan Cancer Research Consortium NCORP
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Detroit, Michigan, Forenede Stater, 48236
- Saint John Hospital and Medical Center
-
Detroit, Michigan, Forenede Stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Escanaba, Michigan, Forenede Stater, 49829
- Green Bay Oncology - Escanaba
-
Flint, Michigan, Forenede Stater, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Cancer Research Consortium of West Michigan NCORP
-
Iron Mountain, Michigan, Forenede Stater, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Marquette, Michigan, Forenede Stater, 49855
- Marquette General Hospital
-
Midland, Michigan, Forenede Stater, 48670
- Mid-Michigan Medical Center - Midland
-
Monroe, Michigan, Forenede Stater, 48162
- Mercy Memorial Hospital
-
Monroe, Michigan, Forenede Stater, 48162
- Toledo Clinic Cancer Centers-Monroe
-
Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital-Royal Oak
-
Saginaw, Michigan, Forenede Stater, 48601
- Saint Mary's of Michigan
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Hospital
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
-
Minnesota
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview-Southdale Hospital
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forenede Stater, 55350
- Hutchinson Area Health Care
-
Litchfield, Minnesota, Forenede Stater, 55355
- Meeker County Memorial Hospital
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Virginia Piper Cancer Institute
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- Saint Joseph's Hospital - Healtheast
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Woodwinds Health Campus
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology and Hematology PA-Woodbury
-
-
Mississippi
-
Keesler Air Force Base, Mississippi, Forenede Stater, 39534
- Keesler Medical Center
-
-
Missouri
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63128
- Saint Anthony's Medical Center
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Montana Cancer Consortium NCORP
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare-West Campus
-
-
Nebraska
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
-
Nevada
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Exeter, New Hampshire, Forenede Stater, 03833
- Exeter Hospital
-
Hooksett, New Hampshire, Forenede Stater, 03106
- New Hampshire Oncology Hematology PA-Hooksett
-
Keene, New Hampshire, Forenede Stater, 03431
- Cheshire Medical Center-Dartmouth-Hitchcock Keene
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center
-
Manchester, New Hampshire, Forenede Stater, 03103
- Elliot Hospital
-
Rochester, New Hampshire, Forenede Stater, 03867
- Frisbie Hospital
-
-
New Jersey
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
Hamilton, New Jersey, Forenede Stater, 08690
- The Cancer Institute of New Jersey Hamilton
-
Livingston, New Jersey, Forenede Stater, 07039
- Saint Barnabas Medical Center
-
Long Branch, New Jersey, Forenede Stater, 07740
- Monmouth Medical Center
-
Morristown, New Jersey, Forenede Stater, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Forenede Stater, 08060
- Virtua Memorial
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Vineland, New Jersey, Forenede Stater, 08360
- Inspira Medical Center Vineland
-
Voorhees, New Jersey, Forenede Stater, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87106
- Hematology Oncology Associates
-
Albuquerque, New Mexico, Forenede Stater, 87110
- Presbyterian Kaseman Hospital
-
-
New York
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
Bronx, New York, Forenede Stater, 10467-2490
- Montefiore Medical Center - Moses Campus
-
Brooklyn, New York, Forenede Stater, 11203
- Kings County Hospital
-
Brooklyn, New York, Forenede Stater, 11203
- University Hospital of Brooklyn
-
Brooklyn, New York, Forenede Stater, 11203
- State University of New York Downstate Medical Center
-
Brooklyn, New York, Forenede Stater, 11212
- Brookdale Hospital Medical Center
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Glens Falls, New York, Forenede Stater, 12801
- Adirondack Cancer Center
-
Lake Success, New York, Forenede Stater, 11042
- Northwell Health NCORP
-
Manhasset, New York, Forenede Stater, 11030
- North Shore University Hospital
-
New Hyde Park, New York, Forenede Stater, 11040
- Long Island Jewish Medical Center
-
New York, New York, Forenede Stater, 10065
- Memorial Sloan-Kettering Cancer Center
-
New York, New York, Forenede Stater, 10065
- Weill Medical College of Cornell University
-
New York, New York, Forenede Stater, 10011
- Saint Vincent's Hospital and Medical Center of New York
-
Staten Island, New York, Forenede Stater, 10305
- Staten Island University Hospital
-
-
North Carolina
-
Asheville, North Carolina, Forenede Stater, 28816
- Hope Women's Cancer Centers-Asheville
-
Asheville, North Carolina, Forenede Stater, 28801
- Mission Hospital-Memorial Campus
-
Burlington, North Carolina, Forenede Stater, 27216
- Cone Health Cancer Center at Alamance Regional
-
Chapel Hill, North Carolina, Forenede Stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Concord, North Carolina, Forenede Stater, 28025
- Carolinas HealthCare System NorthEast
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Pinehurst, North Carolina, Forenede Stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hosiptal
-
Rutherfordton, North Carolina, Forenede Stater, 28139
- Rutherford Hospital
-
Winston-Salem, North Carolina, Forenede Stater, 27103
- Novant Health Forsyth Medical Center
-
Winston-Salem, North Carolina, Forenede Stater, 27104
- Southeast Clinical Oncology Research (SCOR) Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Mid Dakota Clinic
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Hospital
-
Minot, North Dakota, Forenede Stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Bowling Green, Ohio, Forenede Stater, 43402
- Toledo Clinic Cancer Centers-Bowling Green
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45267
- University of Cincinnati
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forenede Stater, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Samaritan North Health Center
-
Dayton, Ohio, Forenede Stater, 45420
- Dayton NCI Community Oncology Research Program
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45804
- Lima Memorial Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Clinic Cancer Centers-Maumee
-
Maumee, Ohio, Forenede Stater, 43537
- Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Saint Charles Hospital
-
Oregon, Ohio, Forenede Stater, 43616
- Toledo Clinic Cancer Centers-Oregon
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Sylvania, Ohio, Forenede Stater, 43560
- Flower Hospital
-
Toledo, Ohio, Forenede Stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43623
- Toledo Clinic Cancer Centers-Toledo
-
Toledo, Ohio, Forenede Stater, 43614
- University of Toledo
-
Toledo, Ohio, Forenede Stater, 43617
- Toledo Community Hospital Oncology Program CCOP
-
Toledo, Ohio, Forenede Stater, 43606
- The Toledo Hospital/Toledo Children's Hospital
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Saint Anne Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Wauseon, Ohio, Forenede Stater, 43567
- Fulton County Health Center
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Xenia, Ohio, Forenede Stater, 45385
- Greene Memorial Hospital
-
Youngstown, Ohio, Forenede Stater, 44501
- Tod Children's Hospital - Forum Health
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
-
Oregon
-
Bend, Oregon, Forenede Stater, 97701
- Bend Memorial Clinic
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Medical Center-Bend
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Milwaukie, Oregon, Forenede Stater, 97222
- Providence Milwaukie Hospital
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente
-
Portland, Oregon, Forenede Stater, 97227
- Legacy Emanuel Hospital and Health Center
-
Portland, Oregon, Forenede Stater, 97213
- Western Oncology Research Consortium
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, Forenede Stater, 19001
- Abington Memorial Hospital
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forenede Stater, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Hershey Cancer Institute-Clinical Trials Office
-
Lancaster, Pennsylvania, Forenede Stater, 17604
- Lancaster General Hospital
-
Langhorne, Pennsylvania, Forenede Stater, 19047
- Saint Mary Medical and Regional Cancer Center
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19114
- Aria Health-Torresdale Campus
-
Philadelphia, Pennsylvania, Forenede Stater, 19118
- Chestnut Hill Health System
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Scranton Hematology Oncology
-
Sellersville, Pennsylvania, Forenede Stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, Forenede Stater, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Forenede Stater, 19380
- Chester County Hospital
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, Forenede Stater, 02905
- Women and Infants Hospital
-
Providence, Rhode Island, Forenede Stater, 02906
- Miriam Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Hospital
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center-Oncology Clinic
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Medical X-Ray Center
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera McKennan Hospital and University Health Center
-
-
Tennessee
-
Chattanooga, Tennessee, Forenede Stater, 37404
- Memorial Hospital
-
Chattanooga, Tennessee, Forenede Stater, 37403
- Erlanger Medical Center
-
Germantown, Tennessee, Forenede Stater, 38138
- Jones Clinic
-
Knoxville, Tennessee, Forenede Stater, 37916
- Thompson Cancer Survival Center
-
Nashville, Tennessee, Forenede Stater, 37208
- Meharry Medical College
-
Nashville, Tennessee, Forenede Stater, 37203
- Nashville Oncology Associates PC
-
-
Texas
-
Dallas, Texas, Forenede Stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Forenede Stater, 75230
- Medical City Dallas Hospital
-
Dallas, Texas, Forenede Stater, 75390
- Clements University Hospital
-
Dallas, Texas, Forenede Stater, 75235
- Zale Lipshy University Hospital
-
Houston, Texas, Forenede Stater, 77030
- M D Anderson Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Laredo, Texas, Forenede Stater, 78041
- Doctor's Hospital of Laredo
-
Lubbock, Texas, Forenede Stater, 79410
- Covenant Medical Center-Lakeside
-
San Antonio, Texas, Forenede Stater, 78229
- University of Texas Health Science Center at San Antonio
-
San Antonio, Texas, Forenede Stater, 78229
- Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
-
Temple, Texas, Forenede Stater, 76508
- Scott and White Memorial Hospital
-
-
Vermont
-
Bennington, Vermont, Forenede Stater, 05201
- Southwestern Vermont Medical Center
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont College of Medicine
-
-
Virginia
-
Fairfax, Virginia, Forenede Stater, 22033
- Kaiser Permanente - Fair Oaks Medical Center
-
Fredericksburg, Virginia, Forenede Stater, 22401
- Fredericksburg Oncology Inc
-
Richmond, Virginia, Forenede Stater, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
-
Washington
-
Auburn, Washington, Forenede Stater, 98001
- MultiCare Auburn Medical Center
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Olympia, Washington, Forenede Stater, 98506-5166
- Providence - Saint Peter Hospital
-
Puyallup, Washington, Forenede Stater, 98372
- MultiCare Good Samaritan Hospital
-
Seattle, Washington, Forenede Stater, 98195
- University of Washington Medical Center
-
Seattle, Washington, Forenede Stater, 98112
- Group Health Cooperative-Seattle
-
Seattle, Washington, Forenede Stater, 98122-4307
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98112
- Group Health Cooperative of Puget Sound Oncology Consortium
-
Spokane, Washington, Forenede Stater, 99202
- Cancer Care Northwest - Spokane South
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, Forenede Stater, 98405
- Saint Joseph Medical Center
-
Tacoma, Washington, Forenede Stater, 98415
- MultiCare Health System
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
-
West Virginia
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Sacred Heart Hospital
-
Eau Claire, Wisconsin, Forenede Stater, 54702
- Midelfort Clinic-Clairemont Campus
-
Elkhorn, Wisconsin, Forenede Stater, 53121
- Aurora Cancer Care-Southern Lakes
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54311-6519
- Aurora BayCare Medical Center
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Hospital and Clinics
-
Madison, Wisconsin, Forenede Stater, 53717
- Dean Hematology and Oncology Clinic
-
Madison, Wisconsin, Forenede Stater, 53715
- UW Health Oncology-One South Park
-
Manitowoc, Wisconsin, Forenede Stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Bay Area Medical Center
-
Marinette, Wisconsin, Forenede Stater, 54143
- Vince Lombardi Cancer Clinic-Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Clinic
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Medical Consultants Limited
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Green Bay Oncology - Oconto Falls
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235
- Green Bay Oncology - Sturgeon Bay
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
-
-
-
-
Bern, Schweiz, 3008
- International Breast Cancer Study Group
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år til 65 år (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
Præmenopausale kvinder (østradiol [E2] i det præmenopausale område [ifølge institutionens parametre]), som opfylder følgende kriterier:
- Patienter, der ikke fik kemoterapi, bør randomiseres inden for 12 uger efter den endelige operation; sådanne patienter bør have østradiol (E2) i det præmenopausale område efter operationen; de eneste patienter, der ikke kræver testning af østradiol (E2) for at bekræfte præmenopausal status, er dem, der har haft regelmæssig menstruation i løbet af de 6 måneder forud for randomiseringen og ikke har brugt nogen form for hormonel prævention eller nogen anden hormonbehandling i løbet af de 6 måneder før. til randomisering
- Patienter, som tidligere har modtaget adjuverende og/eller neoadjuverende kemoterapi, bør randomiseres efter afsluttet kemoterapi og inden for 8 måneder efter den endelige dosis af kemoterapi, så snart præmenopausal status er bekræftet; alle sådanne patienter bør have præmenopausal status bekræftet af en østradiol (E2) i det præmenopausale område mellem 2 uger og 8 måneder efter afsluttet kemoterapi
- Adjuverende trastuzumab (Herceptin ®) er tilladt og anses ikke for at være kemoterapi til bestemmelse af egnethedstidspunkt
- Patienter med midlertidig kemoterapi-induceret amenoré, som genvinder præmenopausal status inden for otte måneder efter den sidste dosis af kemoterapi, er berettigede; (bemærk venligst, at nogle patienter, der tager tamoxifen eller aromatasehæmmere, selv uden tegn på menstruation, kan få genopretning af ovariefunktionen efter kemoterapi og genoptage østradiolsekretionen); hos patienter, der ønsker at deltage i undersøgelsen med postmenopausale hormonniveauer kort efter kemoterapi, anbefales det at kontrollere deres østradiolniveau igen på et senere tidspunkt inden for 8 måneder efter afsluttet kemoterapi, selv i fravær af tilbagevenden af menstruation
- Histologisk bevist, resekeret brystkræft; patologisk materiale bør være tilgængeligt til indsendelse til central gennemgang som en del af kvalitetskontrolforanstaltningerne for denne protokol
- Patienter skal have hormonreceptor-positive tumorer; hvis der er mere end én brysttumor, skal hver tumor være hormonreceptorpositiv; hormonreceptorer skal bestemmes ved hjælp af immunhistokemi; østrogenreceptor (ER) og/eller progesteronreceptor (PgR) skal være større end eller lig med 10 % af tumorcellerne positive ved immunhistokemisk evaluering; biokemisk bestemmelse alene er ikke acceptabel
- Tumoren skal være begrænset til bryst- og aksillære knuder uden påvist metastaser andetsteds, med undtagelse af tumor påvist i interne brystkædeknuder ved vagtpostknudeprocedure; patienter, der modtog neoadjuverende behandling, skal have haft operabel sygdom før neoadjuverende behandling for at være berettiget; patienter, der havde en patologisk evaluering med tru cut eller kernebiopsi af invasiv brystcancer forud for neoadjuverende terapi, og som ikke blev fundet at have nogen invasiv tumor i den patologiske prøve fra endelig kirurgi, er kvalificerede; for disse patienter vil præ-neoadjuverende tumorkarakteristika blive brugt til at definere egnethed; i tilfælde af vedvarende sygdom bør patologiske fund fra den endelige operation anvendes
Patienter skal have gennemgået en ordentlig operation for primær brystkræft uden kendt klinisk resterende lokoregional sygdom:
- En total mastektomi; strålebehandling er valgfri efter mastektomi ELLER
- En brystbevarende procedure (lumpektomi, kvadrantektomi eller delvis mastektomi med marginer fri for invasiv cancer og duktalt brystcarcinom in situ [DCIS]); den lokale patolog skal dokumentere negative resektionsmarginer i patologirapporten; hvis alle andre marginer er klare, tillades en positiv posterior (dyb) margin, forudsat at kirurgen dokumenterer, at udskæringen er udført ned til pectoral fascia, og al tumor er blevet fjernet; Ligeledes, hvis alle andre marginer er klare, tillades en positiv anterior (overfladisk; stødende hud) margin, forudsat at kirurgen dokumenterer, at al tumor er blevet fjernet; strålebehandling af det konserverede bryst er påkrævet; patienter kan randomiseres før, under eller efter afslutning af strålebehandling til brystet
- Enten aksillær lymfeknudedissektion (patologisk undersøgelse af mindst 6 noder anbefales) eller en negativ aksillær sentinel node biopsi (pN0[sn]) er påkrævet; patienter med negative eller mikroskopisk aksillære positive sentinel noder (pN1mi: mikrometastase ingen > 2,0 mm) behøver ikke yderligere aksillær terapi; dem med positive sentinel noder skal have enten en aksillær dissektion eller stråling af aksillære noder
- For International Breast Cancer Study Groups (IBCSG) centre skal patienter have udfyldt baseline Quality of Life (QL) formularer før randomisering; de eneste undtagelser er kognitiv eller fysisk svækkelse, der forstyrrer QL-vurdering eller manglende evne til at læse nogen af de sprog, der er tilgængelige på IBCSG QL-formularer; for ikke-IBCSG-centre skal omfanget af deltagelse i QL-studiet bestemmes ved aktiveringen af forsøget for hver samarbejdsgruppe
- Skriftligt informeret samtykke skal underskrives og dateres af patienten og investigator før randomisering
- Patienterne skal være tilgængelige for opfølgning
- Patienter skal informeres om og acceptere overførsel og håndtering af data og vævsmateriale i overensstemmelse med nationale retningslinjer for databeskyttelse
Ekskluderingskriterier:
- Patienter, der er postmenopausale (dvs. ikke har et østradiol [E2]-niveau i præmenopausale område) efter operation eller efter kemoterapi, alt efter hvad der er senere
- Patienter med fjernmetastatisk sygdom
- Patienter med lokalt fremskreden inoperabel brystkræft inklusive inflammatorisk brystkræft eller supraklavikulær knudepåvirkning eller med forstørrede indre brystknuder (medmindre de er patologisk negative) er ikke kvalificerede; patienter med involverede interne brystknuder påvist ved sentinel node biopsi, som ikke er forstørrede, er kvalificerede
- Patienter med positive endelige marginer (der kun refererer til DCIS og invasiv cancer, ikke lobulært brystcarcinom in situ [LCIS]), undtagen som nævnt; DCIS ved en margin er tilladt, hvis en komplet mastektomi er blevet udført
- Patienter med klinisk påviselig resterende aksillær sygdom
- Patienter med en anamnese med tidligere ipsilateral eller kontralateral invasiv brystkræft; patienter med synkron bilateral invasiv brystkræft (diagnosticeret histologisk inden for 2 måneder) er kvalificerede, hvis den bilaterale sygdom opfylder alle andre berettigelseskriterier
Patienter med tidligere eller samtidig invasiv malignitet er ikke kvalificerede; undtagelserne er patienter med følgende (og kun følgende) maligniteter (tidligere eller samtidige), som er kvalificerede, hvis de behandles tilstrækkeligt:
- Basal- eller pladecellekarcinom i huden
- In situ ikke-brystkarcinom uden invasion
- Kontra- eller ipsilateralt in situ brystcarcinom
Ikke-bryst-invasiv malignitet diagnosticeret for mindst 5 år siden og uden gentagelse:
- Fase I papillær skjoldbruskkirtelkræft
- Stadie Ia karcinom i livmoderhalsen
- Stadie Ia eller b endometrioid endometriecancer
- Borderline eller stadium I ovariecancer
- Patienter med andre ikke-maligne systemiske sygdomme (kardiovaskulære, nyre-, lever-, lunge- osv.), som ville forhindre langvarig opfølgning; patienter med tidligere trombose (f.eks. dyb venetrombose [DVT]) og/eller emboli kan kun inkluderes, hvis det er medicinsk egnet
- Patienter, der har haft en bilateral oophorektomi eller ovariebestråling; patienter, som vil blive anbefalet at gennemgå ooforektomi inden for 5 år (f.eks. brystkræftmodtagelighedsgen [BRCA]1/2 genbærere), og derfor er randomisering til en behandlingsarm uden OFS uhensigtsmæssig
- Patienter med en historie med manglende overholdelse af medicinske regimer og patienter, der anses for at være potentielt upålidelige
- Patienter, der er gravide eller ammer på tidspunktet for randomisering, eller som ønsker en graviditet inden for 5 år; patienter, der planlægger at bruge yderligere hormonbehandling bortset fra den randomiserede behandling i løbet af de næste fem år, inklusive alle typer hormonprævention; en graviditetstest anbefales til kvinder i den fødedygtige alder, som er seksuelt aktive og ikke bruger pålidelige præventionsmetoder
- Patienter, der modtog endokrin behandling (inklusive neoadjuverende og adjuverende) i mere end 8 måneder efter deres brystkræftdiagnose; patienter, der modtager endokrin behandling ved randomisering (og har modtaget den i mindre end 8 måneder), kan fortsætte en sådan behandling, indtil protokolspecificeret tamoxifen/exemestan påbegyndes
- Patienter, der tog tamoxifen eller anden selektiv østrogenreceptormodulator (SERM) (f. Raloxifen) eller hormonsubstitutionsterapi (HRT) inden for et år før deres brystkræftdiagnose; tidligere orale præventionsmidler er tilladt
- Patienter, der har modtaget GnRH-analoger som en del af deres brystkræftbehandling forud for randomisering
- Patienter med psykiatriske, vanedannende eller en hvilken som helst lidelse, der ville forhindre overholdelse af protokolkrav
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Tamoxifen
Tamoxifen 20 mg oralt dagligt i 5 år
|
Korrelative undersøgelser
Hjælpestudier
Andre navne:
Tamoxifen 20 mg oralt dagligt i 5 år
Andre navne:
|
|
Eksperimentel: T+OFS
Tamoxifen 20 mg oralt dagligt i 5 år plus ovariefunktionsundertrykkelse (OFS; triptorelin (GnRH-analog) 3,75 mg ved im-injektion 28 dage i 5 år; eller kirurgisk oophorektomi; eller ovariebestråling)
|
Korrelative undersøgelser
Hjælpestudier
Andre navne:
Tamoxifen 20 mg oralt dagligt i 5 år
Andre navne:
Gennemgå bilateral kirurgisk oophorektomi
Andre navne:
Gennemgå ovariebestråling
Andre navne:
3,75 mg ved im-injektion hver 28 dage i 5 år
Andre navne:
|
|
Eksperimentel: E+OFS
Exemestan 25 mg oralt dagligt i 5 år plus undertrykkelse af ovariefunktion (OFS; triptorelin (GnRH-analog) 3,75 mg ved im-injektion 28 dage i 5 år; eller kirurgisk oophorektomi; eller ovariebestråling)
|
Korrelative undersøgelser
Hjælpestudier
Andre navne:
Gennemgå bilateral kirurgisk oophorektomi
Andre navne:
Gennemgå ovariebestråling
Andre navne:
3,75 mg ved im-injektion hver 28 dage i 5 år
Andre navne:
Exemestan 25 mg oralt dagligt i 5 år plus undertrykkelse af ovariefunktion
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Sygdomsfri overlevelse
Tidsramme: 5-års estimater, rapporteret ved en median opfølgning på 67 måneder.
|
Estimeret procentdel af patienter i live og sygdomsfri efter 5 år fra randomisering, hvor sygdomsfri overlevelse er defineret som tiden fra randomisering til den første forekomst af en af følgende: invasiv brystcancer recidiv på lokalt, regionalt eller fjerntliggende sted, invasiv kontralateral brystkræft, anden (ikke-bryst) invasiv cancer eller død uden cancerhændelse; eller censureret på datoen for sidste opfølgning.
|
5-års estimater, rapporteret ved en median opfølgning på 67 måneder.
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Brystkræftfrit interval
Tidsramme: 5-års estimater, rapporteret ved en median opfølgning på 67 måneder.
|
Estimeret procentdel af patienter i live og sygdomsfri efter 5 år fra randomisering, hvor brystkræftfrit interval er defineret som tiden fra randomisering til invasiv brystkræfttilbagefald på lokalt, regionalt eller fjerntliggende sted, eller invasiv kontralateral brystkræft; eller censureret på datoen for sidste opfølgning.
|
5-års estimater, rapporteret ved en median opfølgning på 67 måneder.
|
|
Fjernt gentagelsesfrit interval
Tidsramme: 5-års estimater, rapporteret ved en median opfølgning på 67 måneder.
|
Estimeret procentdel af patienter i live og sygdomsfri efter 5 år fra randomisering, hvor fjernt tilbagefaldsfrit interval er defineret som tiden fra randomisering til invasiv brystcancer tilbagevenden på et fjerntliggende sted eller invasiv kontralateral brystcancer; eller censureret på datoen for sidste opfølgning.
|
5-års estimater, rapporteret ved en median opfølgning på 67 måneder.
|
|
Samlet overlevelse
Tidsramme: 8-års skøn, rapporteret ved en medianopfølgning på 8 år
|
Estimeret procentdel af patienter i live 8 år fra randomisering, hvor samlet overlevelse er defineret som tiden fra randomisering til død uanset årsag; eller censureret på datoen for sidst kendt i live.
|
8-års skøn, rapporteret ved en medianopfølgning på 8 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Gini Fleming, ETOP IBCSG Partners Foundation
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Pagani O, Francis PA, Fleming GF, Walley BA, Viale G, Colleoni M, Lang I, Gomez HL, Tondini C, Pinotti G, Di Leo A, Coates AS, Goldhirsch A, Gelber RD, Regan MM; SOFT and TEXT Investigators and International Breast Cancer Study Group. Absolute Improvements in Freedom From Distant Recurrence to Tailor Adjuvant Endocrine Therapies for Premenopausal Women: Results From TEXT and SOFT. J Clin Oncol. 2020 Apr 20;38(12):1293-1303. doi: 10.1200/JCO.18.01967. Epub 2019 Oct 16.
- Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Lang I, Gomez HL, Tondini C, Ciruelos E, Burstein HJ, Bonnefoi HR, Bellet M, Martino S, Geyer CE Jr, Goetz MP, Stearns V, Pinotti G, Puglisi F, Spazzapan S, Climent MA, Pavesi L, Ruhstaller T, Davidson NE, Coleman R, Debled M, Buchholz S, Ingle JN, Winer EP, Maibach R, Rabaglio-Poretti M, Ruepp B, Di Leo A, Coates AS, Gelber RD, Goldhirsch A, Regan MM; SOFT and TEXT Investigators and the International Breast Cancer Study Group. Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer. N Engl J Med. 2018 Jul 12;379(2):122-137. doi: 10.1056/NEJMoa1803164. Epub 2018 Jun 4.
- Regan MM, Walley BA, Francis PA, Fleming GF, Lang I, Gomez HL, Colleoni M, Tondini C, Pinotti G, Salim M, Spazzapan S, Parmar V, Ruhstaller T, Abdi EA, Gelber RD, Coates AS, Goldhirsch A, Pagani O. Concurrent and sequential initiation of ovarian function suppression with chemotherapy in premenopausal women with endocrine-responsive early breast cancer: an exploratory analysis of TEXT and SOFT. Ann Oncol. 2017 Sep 1;28(9):2225-2232. doi: 10.1093/annonc/mdx285.
- Regan MM, Francis PA, Pagani O, Fleming GF, Walley BA, Viale G, Colleoni M, Lang I, Gomez HL, Tondini C, Pinotti G, Price KN, Coates AS, Goldhirsch A, Gelber RD. Absolute Benefit of Adjuvant Endocrine Therapies for Premenopausal Women With Hormone Receptor-Positive, Human Epidermal Growth Factor Receptor 2-Negative Early Breast Cancer: TEXT and SOFT Trials. J Clin Oncol. 2016 Jul 1;34(19):2221-31. doi: 10.1200/JCO.2015.64.3171. Epub 2016 Apr 4.
- Bernhard J, Luo W, Ribi K, Colleoni M, Burstein HJ, Tondini C, Pinotti G, Spazzapan S, Ruhstaller T, Puglisi F, Pavesi L, Parmar V, Regan MM, Pagani O, Fleming GF, Francis PA, Price KN, Coates AS, Gelber RD, Goldhirsch A, Walley BA. Patient-reported outcomes with adjuvant exemestane versus tamoxifen in premenopausal women with early breast cancer undergoing ovarian suppression (TEXT and SOFT): a combined analysis of two phase 3 randomised trials. Lancet Oncol. 2015 Jul;16(7):848-58. doi: 10.1016/S1470-2045(15)00049-2. Epub 2015 Jun 16.
- Francis PA, Regan MM, Fleming GF, Lang I, Ciruelos E, Bellet M, Bonnefoi HR, Climent MA, Da Prada GA, Burstein HJ, Martino S, Davidson NE, Geyer CE Jr, Walley BA, Coleman R, Kerbrat P, Buchholz S, Ingle JN, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, Colleoni M, Viale G, Coates AS, Goldhirsch A, Gelber RD; SOFT Investigators; International Breast Cancer Study Group. Adjuvant ovarian suppression in premenopausal breast cancer. N Engl J Med. 2015 Jan 29;372(5):436-46. doi: 10.1056/NEJMoa1412379. Epub 2014 Dec 11.
- Francis PA, Fleming GF, Lang I, Ciruelos EM, Bonnefoi HR, Bellet M, Bernardo A, Climent MA, Martino S, Bermejo B, Burstein HJ, Davidson NE, Geyer CE Jr, Walley BA, Ingle JN, Coleman RE, Muller B, Le Du F, Loibl S, Winer EP, Ruepp B, Loi S, Colleoni M, Coates AS, Gelber RD, Goldhirsch A, Regan MM; SOFT Investigators and the International Breast Cancer Study Group (a division of ETOP IBCSG Partners Foundation). Adjuvant Endocrine Therapy in Premenopausal Breast Cancer: 12-Year Results From SOFT. J Clin Oncol. 2023 Mar 1;41(7):1370-1375. doi: 10.1200/JCO.22.01065. Epub 2022 Dec 9. Erratum In: J Clin Oncol. 2023 Sep 1;41(25):4187.
- Ribi K, Luo W, Bernhard J, Francis PA, Burstein HJ, Ciruelos E, Bellet M, Pavesi L, Lluch A, Visini M, Parmar V, Tondini C, Kerbrat P, Perello A, Neven P, Torres R, Lombardi D, Puglisi F, Karlsson P, Ruhstaller T, Colleoni M, Coates AS, Goldhirsch A, Price KN, Gelber RD, Regan MM, Fleming GF. Adjuvant Tamoxifen Plus Ovarian Function Suppression Versus Tamoxifen Alone in Premenopausal Women With Early Breast Cancer: Patient-Reported Outcomes in the Suppression of Ovarian Function Trial. J Clin Oncol. 2016 May 10;34(14):1601-10. doi: 10.1200/JCO.2015.64.8675. Epub 2016 Mar 28.
- Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Lang I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR, Martino S, Geyer CE Jr, Pinotti G, Puglisi F, Crivellari D, Ruhstaller T, Winer EP, Rabaglio-Poretti M, Maibach R, Ruepp B, Giobbie-Hurder A, Price KN, Bernhard J, Luo W, Ribi K, Viale G, Coates AS, Gelber RD, Goldhirsch A, Francis PA; TEXT and SOFT Investigators; International Breast Cancer Study Group. Adjuvant exemestane with ovarian suppression in premenopausal breast cancer. N Engl J Med. 2014 Jul 10;371(2):107-18. doi: 10.1056/NEJMoa1404037. Epub 2014 Jun 1.
- Regan MM, Pagani O, Fleming GF, Walley BA, Price KN, Rabaglio M, Maibach R, Ruepp B, Coates AS, Goldhirsch A, Colleoni M, Gelber RD, Francis PA; International Breast Cancer Study; GroupSOFT and TEXT Investigators. Adjuvant treatment of premenopausal women with endocrine-responsive early breast cancer: design of the TEXT and SOFT trials. Breast. 2013 Dec;22(6):1094-100. doi: 10.1016/j.breast.2013.08.009. Epub 2013 Oct 2.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
17. december 2003
Primær færdiggørelse (Faktiske)
1. maj 2014
Studieafslutning (Anslået)
1. december 2025
Datoer for studieregistrering
Først indsendt
6. august 2003
Først indsendt, der opfyldte QC-kriterier
6. august 2003
Først opslået (Anslået)
7. august 2003
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
1. januar 2024
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
14. december 2023
Sidst verificeret
1. december 2023
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
- Hudsygdomme
- Neoplasmer
- Neoplasmer efter sted
- Brystsygdomme
- Brystneoplasmer
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Enzymhæmmere
- Antineoplastiske midler
- Hormoner, hormonsubstitutter og hormonantagonister
- Antineoplastiske midler, hormonelle
- Psykotropiske stoffer
- Antidepressive midler
- Antidepressive midler, anden generation
- Hormonantagonister
- Knogletæthedsbevarende midler
- Aromatasehæmmere
- Steroidsyntesehæmmere
- Østrogenantagonister
- Svangerskabsforebyggende midler, hormonelle
- Præventionsmidler
- Reproduktive kontrolmidler
- Præventionsmidler, kvinder
- Selektive østrogenreceptormodulatorer
- Østrogenreceptormodulatorer
- Luteolytiske midler
- Tamoxifen
- Triptorelin Pamoate
- Exemestan
- Tryptofan
Andre undersøgelses-id-numre
- IBCSG 24-02 / BIG 2-02
- NCI-2009-01086 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- CDR0000316456
- BIG 2-02
- 2004-000166-13
- IBCSG-24-02 (Anden identifikator: CTEP)
- U24CA075362 (U.S. NIH-bevilling/kontrakt)
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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