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Carboplatin og Paclitaxel med eller uden Bevacizumab til behandling af patienter med trin III eller trin IV ovarieepitel, primær peritoneal eller æggelederkræft

19. juli 2019 opdateret af: National Cancer Institute (NCI)

Et fase III-forsøg med carboplatin og paclitaxel plus placebo versus carboplatin og paclitaxel plus samtidig bevacizumab (NSC # 704865) efterfulgt af placebo, versus carboplatin og paclitaxel plus samtidig og forlænget bevacizumab, hos kvinder med nydiagnosticeret, tidligere epitelal III eller IV ubehandlet Kræft i æggestokkene, primær peritoneal eller æggeleder

Dette randomiserede fase III-studie undersøger carboplatin, paclitaxel og bevacizumab for at se, hvor godt de virker sammenlignet med carboplatin, paclitaxel og placebo ved behandling af patienter med stadium III eller stadium IV ovarieepitel, primær peritoneal eller æggelederkræft. Lægemidler, der bruges i kemoterapi, såsom carboplatin og paclitaxel, virker på forskellige måder for at stoppe væksten af ​​tumorceller, enten ved at dræbe cellerne eller ved at forhindre dem i at dele sig. Monoklonale antistoffer, såsom bevacizumab, kan interferere med tumorcellernes evne til at vokse og sprede sig. Det vides endnu ikke, om carboplatin, paclitaxel og bevacizumab er mere effektive end carboplatin, paclitaxel og placebo til behandling af ovarieepitel-, primær peritoneal- eller æggelederkræft.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. For at bestemme, om tilføjelsen af ​​5 samtidige cyklusser af bevacizumab til 6 cyklusser af standardbehandling (carboplatin og paclitaxel) (arm II) øger varigheden af ​​progressionsfri overlevelse (PFS) sammenlignet med 6 cyklusser af standardterapi alene (Arm) I) hos kvinder med nydiagnosticeret stadium III (med enhver alvorlig resterende sygdom) og stadium IV, epitelial ovariecancer, peritoneal primær eller æggelederkræft.

II. For at bestemme, om tilføjelsen af ​​5 samtidige cyklusser af bevacizumab plus forlænget bevacizumab i 16 cyklusser ud over de 6 cyklusser af standardterapi (carboplatin og paclitaxel) (arm III) øger progressionsfri overlevelse sammenlignet med 6 cyklusser af standardterapi (arm I) hos kvinder med nydiagnosticeret stadium III (med enhver alvorlig resterende sygdom) og stadium IV, epitelial ovariecancer, peritoneal primær eller æggeledercancer.

SEKUNDÆRE MÅL:

I. I tilfælde af at både Arm II- og Arm III-regimerne er overlegne i forhold til Arm I-regimet med hensyn til progressionsfri overlevelse, for at bestemme, om Arm III-regimet forlænger progressionsfri overlevelse sammenlignet med Arm II-regimet.

II. For at bestemme, om Arm II- eller Arm III-regimet øger varigheden af ​​den samlede overlevelse sammenlignet med Arm I-regimet.

III. At sammenligne hvert af de eksperimentelle regimer med Arm I regimet med hensyn til forekomsten af ​​alvorlig toksicitet eller alvorlige bivirkninger.

IV. For at bestemme indvirkningen på livskvalitet (QOL, målt ved funktionel vurdering af kræftterapi-ovarie [FACT-O] forsøgsresultatindeks [TOI]) efter behandling med ovenstående regimer.

TERTIÆRE MÅL:

I. At vurdere sammenhængen mellem angiogene markører og klinisk udfald inklusive tumorrespons, progressionsfri overlevelse og samlet overlevelse hos patienter randomiseret til standard cytotoksisk kemoterapi (paclitaxel og carboplatin) uden bevacizumab, med samtidig bevacizumab eller med forlænget bevacizumab.

II. At vurdere den prædiktive værdi af et sæt gener, hvis ekspression korrelerer med overlevelse af patienter med stadium III (med enhver grov resterende sygdom) og stadium IV, epitelial ovariecancer, peritoneal primær eller æggeledercancer.

III. At banke fuldblod til forskning. IV. For at bestemme, om genetiske variationer i gener forbundet med essentiel hypertension, herunder WNK lysin-deficient proteinkinase 1 (WNK1), forudsiger G-proteinkoblet receptorkinase 4 (GRK4) og kallikrein B (KLKB1) hvilke patienter, der sandsynligvis vil udvikle bevacizumab-induceret hypertension.

OVERSIGT: Patienterne randomiseres til 1 ud af 3 behandlingsarme.

ARM I: Patienterne får paclitaxel intravenøst ​​(IV) over 3 timer og carboplatin IV over 30 minutter på dag 1. Fra kursus 2 får patienterne også placebo IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb. Begyndende i kursus 7 får patienter placebo alene IV over 30-90 minutter på dag 1. Behandling med placebo gentages hver 21. dag i op til 22 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II: Patienterne får paclitaxel og carboplatin som i arm I. Fra og med forløb 2 får patienterne også bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb. Begyndende i kursus 7 får patienter placebo alene IV over 30-90 minutter på dag 1. Behandling med placebo gentages hver 21. dag i op til 22 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM III: Patienterne får paclitaxel og carboplatin som i arm I. Fra og med forløb 2 får patienterne også bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb. Fra kursus 7 får patienterne bevacizumab alene IV over 30-90 minutter på dag 1. Behandling med bevacizumab gentages hver 21. dag i op til 22 behandlingsforløb i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afslutning af studiebehandlingen følges patienterne op hver 3. måned i 2 år, hver 6. måned i 3 år og derefter årligt.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1873

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Canada
    • Ontario
      • Toronto, Ontario, Canada, M4N 3M5
        • Odette Cancer Centre- Sunnybrook Health Sciences Centre
  • Forenede Stater
    • Alabama
      • Anniston, Alabama, Forenede Stater, 36202
        • Northeast Alabama Regional Medical Center
      • Birmingham, Alabama, Forenede Stater, 35233
        • University of Alabama at Birmingham Cancer Center
      • Huntsville, Alabama, Forenede Stater, 35805
        • Clearview Cancer Institute
      • Mobile, Alabama, Forenede Stater, 36607
        • Mobile Infirmary Medical Center
    • Arizona
      • Glendale, Arizona, Forenede Stater, 85306
        • Banner Thunderbird Medical Center
      • Mesa, Arizona, Forenede Stater, 85202
        • Banner Desert Medical Center
      • Mesa, Arizona, Forenede Stater, 85206
        • Banner Baywood Medical Center
      • Phoenix, Arizona, Forenede Stater, 85006
        • Banner Good Samaritan Medical Center
      • Phoenix, Arizona, Forenede Stater, 85006
        • Western Regional CCOP
      • Scottsdale, Arizona, Forenede Stater, 85259
        • Mayo Clinic in Arizona
    • Arkansas
      • Fayetteville, Arkansas, Forenede Stater, 72703
        • Highlands Oncology Group PA - Fayetteville
      • Fayetteville, Arkansas, Forenede Stater, 72703
        • Washington Regional Medical Center - Fayetteville
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Mercy Hospital Fort Smith
      • Little Rock, Arkansas, Forenede Stater, 72205
        • University of Arkansas for Medical Sciences
    • California
      • Burbank, California, Forenede Stater, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Castro Valley, California, Forenede Stater, 94546
        • Eden Hospital Medical Center
      • Castro Valley, California, Forenede Stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forenede Stater, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Concord, California, Forenede Stater, 94520
        • John Muir Medical Center-Concord Campus
      • Emeryville, California, Forenede Stater, 94608
        • Bay Area Breast Surgeons Inc
      • Fairfield, California, Forenede Stater, 94533
        • Northbay Cancer Center
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fremont, California, Forenede Stater, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Fresno, California, Forenede Stater, 93720
        • Cancer Care Associates of Fresno Medical Group Inc
      • Fullerton, California, Forenede Stater, 92835
        • Saint Jude Medical Center
      • Loma Linda, California, Forenede Stater, 92354
        • Loma Linda University Medical Center
      • Long Beach, California, Forenede Stater, 90806
        • Long Beach Memorial Medical Center-Todd Cancer Institute
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars-Sinai Medical Center
      • Los Angeles, California, Forenede Stater, 90095
        • UCLA / Jonsson Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Martinez, California, Forenede Stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Mountain View, California, Forenede Stater, 94040
        • El Camino Hospital
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forenede Stater, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, Forenede Stater, 94602
        • Highland General Hospital
      • Oakland, California, Forenede Stater, 94609
        • Tom K Lee Inc
      • Oakland, California, Forenede Stater, 94609
        • Bay Area Tumor Institute
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Palo Alto, California, Forenede Stater, 94304
        • Stanford Cancer Institute
      • Pleasanton, California, Forenede Stater, 94588
        • Valley Care Health System - Pleasanton
      • Pleasanton, California, Forenede Stater, 94588
        • Valley Medical Oncology Consultants
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente - Sacramento
      • San Diego, California, Forenede Stater, 92108
        • Kaiser Permanente-San Diego Mission
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forenede Stater, 94115
        • UCSF Medical Center-Mount Zion
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Pablo, California, Forenede Stater, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Permanente-San Rafael
      • Santa Barbara, California, Forenede Stater, 93105
        • Cancer Center of Santa Barbara
      • Santa Barbara, California, Forenede Stater, 93105
        • Santa Barbara Hematology Oncology Group Inc-Santa Barbara
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Walnut Creek, California, Forenede Stater, 94598
        • John Muir Medical Center-Walnut Creek
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Aurora, Colorado, Forenede Stater, 80010
        • Colorado Gynecologic Oncology Group
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80909
        • Memorial Hospital Colorado Springs
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Exempla Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80224-2522
        • Colorado Cancer Research Program CCOP
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Englewood, Colorado, Forenede Stater, 80110
        • Rocky Mountain Gynecologic Oncology PC
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Front Range Cancer Specialists
      • Grand Junction, Colorado, Forenede Stater, 81502
        • Saint Mary's Hospital and Regional Medical Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Lakewood, Colorado, Forenede Stater, 80228
        • Saint Anthony Hospital
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Longmont, Colorado, Forenede Stater, 80501
        • Longmont United Hospital
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
      • Thornton, Colorado, Forenede Stater, 80229
        • North Suburban Medical Center
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • Exempla Lutheran Medical Center
    • Connecticut
      • Hartford, Connecticut, Forenede Stater, 06102
        • Hartford Hospital
      • Hartford, Connecticut, Forenede Stater, 06105
        • Saint Francis Hospital and Medical Center
      • Manchester, Connecticut, Forenede Stater, 06040
        • Manchester Memorial Hospital
      • New Britain, Connecticut, Forenede Stater, 06050
        • The Hospital of Central Connecticut
      • New Haven, Connecticut, Forenede Stater, 06520
        • Yale University
      • Norwalk, Connecticut, Forenede Stater, 06856
        • Norwalk Hospital
      • Stamford, Connecticut, Forenede Stater, 06904
        • Stamford Hospital/Bennett Cancer Center
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Newark, Delaware, Forenede Stater, 19713
        • Christiana Gynecologic Oncology LLC
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20010
        • Washington Hospital Center
    • Florida
      • Clearwater, Florida, Forenede Stater, 33756
        • Morton Plant Hospital
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Holy Cross Hospital
      • Fort Myers, Florida, Forenede Stater, 33901
        • Lee Memorial Health System
      • Fort Myers, Florida, Forenede Stater, 33905
        • Florida Gynecologic Oncology
      • Jacksonville, Florida, Forenede Stater, 32224-9980
        • Mayo Clinic in Florida
      • Jacksonville, Florida, Forenede Stater, 32204
        • Saint Vincent's Medical Center
      • Jupiter, Florida, Forenede Stater, 33458
        • Jupiter Medical Center
      • Miami, Florida, Forenede Stater, 33136
        • University of Miami Miller School of Medicine-Sylvester Cancer Center
      • Miami Beach, Florida, Forenede Stater, 33140
        • Mount Sinai Medical Center
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Hospital Orlando
      • Orlando, Florida, Forenede Stater, 32806
        • UF Cancer Center at Orlando Health
      • Saint Petersburg, Florida, Forenede Stater, 33701
        • Bayfront Outpatient Health Clinic
      • Sarasota, Florida, Forenede Stater, 34239
        • Sarasota Memorial Hospital
      • West Palm Beach, Florida, Forenede Stater, 33401
        • Florida Cancer Specialists-West Palm Beach
    • Georgia
      • Albany, Georgia, Forenede Stater, 31701
        • Phoebe Putney Memorial Hospital
      • Atlanta, Georgia, Forenede Stater, 30303
        • Grady Health System
      • Atlanta, Georgia, Forenede Stater, 30322
        • Emory University/Winship Cancer Institute
      • Augusta, Georgia, Forenede Stater, 30912
        • Georgia Regents University Medical Center
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Medical Center
      • Macon, Georgia, Forenede Stater, 31201
        • Central Georgia Gynecologic Oncology
      • Savannah, Georgia, Forenede Stater, 31404
        • Memorial University Medical Center
    • Hawaii
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • The Cancer Center of Hawaii-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96826
        • Kapiolani Medical Center for Women and Children
      • Honolulu, Hawaii, Forenede Stater, 96859
        • Tripler Army Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Oncare Hawaii Inc-POB II
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Oncare Hawaii Inc-Kuakini
      • Wailuku, Hawaii, Forenede Stater, 96793
        • Maui Memorial Medical Center
      • Wailuku, Hawaii, Forenede Stater, 96793
        • Pacific Cancer Institute of Maui
    • Idaho
      • Boise, Idaho, Forenede Stater, 83712
        • Saint Luke's Mountain States Tumor Institute
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Saint Anthony's Health
      • Arlington Heights, Illinois, Forenede Stater, 60005
        • Northwest Community Hospital
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush - Copley Medical Center
      • Bloomington, Illinois, Forenede Stater, 61701
        • Saint Joseph Medical Center
      • Canton, Illinois, Forenede Stater, 61520
        • Graham Hospital Association
      • Carthage, Illinois, Forenede Stater, 62321
        • Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60612
        • Rush University Medical Center
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forenede Stater, 60625
        • Swedish Covenant Hospital
      • Chicago, Illinois, Forenede Stater, 60631
        • Presence Resurrection Medical Center
      • Chicago, Illinois, Forenede Stater, 60640
        • Weiss Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Elmhurst, Illinois, Forenede Stater, 60126
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, Forenede Stater, 61530
        • Eureka Hospital
      • Evanston, Illinois, Forenede Stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Evanston, Illinois, Forenede Stater, 60202
        • Saint Francis Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Galesburg Cottage Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare Galesburg
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Memorial Hospital
      • Havana, Illinois, Forenede Stater, 62644
        • Mason District Hospital
      • Hopedale, Illinois, Forenede Stater, 61747
        • Hopedale Medical Complex - Hospital
      • Joliet, Illinois, Forenede Stater, 60435
        • Joliet Oncology-Hematology Associates Limited
      • Kewanee, Illinois, Forenede Stater, 61443
        • Kewanee Hospital
      • Macomb, Illinois, Forenede Stater, 61455
        • Mcdonough District Hospital
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Moline, Illinois, Forenede Stater, 61265
        • Garneau, Stewart C MD (UIA Investigator)
      • Moline, Illinois, Forenede Stater, 61265
        • Porubcin, Michael MD (UIA Investigator)
      • Moline, Illinois, Forenede Stater, 61265
        • Sharis, Christine M MD (UIA Investigator)
      • Moline, Illinois, Forenede Stater, 61265
        • Stoffel, Thomas J MD (UIA Investigator)
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Good Samaritan Regional Health Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center Foundation
      • Normal, Illinois, Forenede Stater, 61761
        • Bromenn Regional Medical Center
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, Forenede Stater, 61350
        • Ottawa Regional Hospital and Healthcare Center
      • Palatine, Illinois, Forenede Stater, 60067
        • Chicago Gynecologic Oncology SC
      • Park Ridge, Illinois, Forenede Stater, 60068
        • Advocate Lutheran General Hospital
      • Pekin, Illinois, Forenede Stater, 61554
        • Pekin Cancer Treatment Center
      • Pekin, Illinois, Forenede Stater, 61554
        • Pekin Hospital
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forenede Stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forenede Stater, 61603
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois Oncology Research Association CCOP
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois Valley Hospital
      • Princeton, Illinois, Forenede Stater, 61356
        • Perry Memorial Hospital
      • Rockford, Illinois, Forenede Stater, 61108
        • Saint Anthony Medical Center
      • Spring Valley, Illinois, Forenede Stater, 61362
        • Saint Margaret's Hospital
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Clinic-Urbana Main
    • Indiana
      • Beech Grove, Indiana, Forenede Stater, 46107
        • Franciscan St. Francis Health-Beech Grove
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Fort Wayne, Indiana, Forenede Stater, 46845
        • Fort Wayne Medical Oncology and Hematology Inc-Parkview
      • Indianapolis, Indiana, Forenede Stater, 46202
        • Indiana University/Melvin and Bren Simon Cancer Center
      • Indianapolis, Indiana, Forenede Stater, 46260
        • Saint Vincent Hospital and Health Services
      • Kokomo, Indiana, Forenede Stater, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Forenede Stater, 46350
        • IU Health La Porte Hospital
      • Michigan City, Indiana, Forenede Stater, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Munster, Indiana, Forenede Stater, 46321
        • The Community Hospital
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Hospital and Health Care Services
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46617
        • South Bend Clinic
      • South Bend, Indiana, Forenede Stater, 46628
        • Northern Indiana Cancer Research Consortium CCOP
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC-William R Bliss Cancer Center
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Constantinou, Costas L MD (UIA Investigator)
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Cedar Rapids Oncology Association
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Davenport, Iowa, Forenede Stater, 52803
        • Genesis Medical Center - East Campus
      • Davenport, Iowa, Forenede Stater, 52804
        • Genesis Medical Center - West Campus
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Des Moines, Iowa, Forenede Stater, 50307
        • Mercy Capitol
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Oncology Research Association CCOP
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Saint Luke's Regional Medical Center
      • Sioux City, Iowa, Forenede Stater, 51101-1733
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Mercy Medical Center-Sioux City
      • Waterloo, Iowa, Forenede Stater, 50702
        • Covenant Medical Center
      • Waterloo, Iowa, Forenede Stater, 50701
        • Cedar Valley Medical Specialists
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, Forenede Stater, 66160
        • University of Kansas Cancer Center
      • Kansas City, Kansas, Forenede Stater, 66112
        • Providence Medical Center
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66210
        • Radiation Oncology Practice Corporation Southwest
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Shawnee Mission, Kansas, Forenede Stater, 66204
        • Shawnee Mission Medical Center-KCCC
      • Topeka, Kansas, Forenede Stater, 66606
        • Saint Francis Hospital and Medical Center - Topeka
      • Topeka, Kansas, Forenede Stater, 66604
        • Stormont-Vail Regional Health Center
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Main Office
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita CCOP
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40536
        • University of Kentucky/Markey Cancer Center
      • Louisville, Kentucky, Forenede Stater, 40202
        • Norton Hospital Pavilion and Medical Campus
      • Louisville, Kentucky, Forenede Stater, 40202
        • The James Graham Brown Cancer Center at University of Louisville
    • Louisiana
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Tulane University Health Sciences Center
      • Shreveport, Louisiana, Forenede Stater, 71101
        • Christus Schumpert Saint Mary's Place
    • Maine
      • Bangor, Maine, Forenede Stater, 04401
        • Eastern Maine Medical Center
      • Portland, Maine, Forenede Stater, 04102
        • Maine Medical Center-Bramhall Campus
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21237
        • MedStar Franklin Square Medical Center/Weinberg Cancer Institute
      • Baltimore, Maryland, Forenede Stater, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Baltimore, Maryland, Forenede Stater, 21204
        • Greater Baltimore Medical Center
      • Easton, Maryland, Forenede Stater, 21601
        • The Memorial Hospital at Easton
      • Easton, Maryland, Forenede Stater, 21601
        • Memorial Hospital at Easton - Shore Regional Cancer Center
      • Elkton, Maryland, Forenede Stater, 21921
        • Union Hospital of Cecil County
      • Kensington, Maryland, Forenede Stater, 20895
        • Associates in Oncology Hematology PC -Kensington
      • Largo, Maryland, Forenede Stater, 20774
        • Kaiser Permanente - Largo Medical Center
      • Lutherville, Maryland, Forenede Stater, 21093
        • Kaiser Permanente - Towson Medical Center
      • Rockville, Maryland, Forenede Stater, 20850
        • Kaiser Permanente - Shady Grove Medical Center
      • Rockville, Maryland, Forenede Stater, 20850
        • Maryland Oncology Hematology PA-Aquilino Cancer Center
      • Silver Spring, Maryland, Forenede Stater, 20910
        • Holy Cross Hospital
    • Massachusetts
      • Pittsfield, Massachusetts, Forenede Stater, 01201
        • Berkshire Hematology Oncology PC
      • Springfield, Massachusetts, Forenede Stater, 01199
        • Baystate Medical Center
      • Worcester, Massachusetts, Forenede Stater, 01655
        • University of Massachusetts Medical School
      • Worcester, Massachusetts, Forenede Stater, 01605
        • Commonwealth Hematology Oncology PC-Worcester
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Bixby Medical Center
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106-0995
        • Saint Joseph Mercy Hospital
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Michigan Cancer Research Consortium CCOP
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University Of Michigan Comprehensive Cancer Center
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Big Rapids, Michigan, Forenede Stater, 49307
        • Spectrum Health Big Rapids Hospital
      • Dearborn, Michigan, Forenede Stater, 48124
        • Oakwood Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48236
        • Saint John Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Escanaba, Michigan, Forenede Stater, 49431
        • Green Bay Oncology - Escanaba
      • Flint, Michigan, Forenede Stater, 48502
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48532
        • Genesys Regional Medical Center-West Flint Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Grand Rapids Clinical Oncology Program
      • Grand Rapids, Michigan, Forenede Stater, 49506
        • Spectrum Health-Blodgett Campus
      • Grand Rapids, Michigan, Forenede Stater, 49546
        • Gynecologic Oncology of West Michigan PLLC
      • Holland, Michigan, Forenede Stater, 49423
        • Holland Community Hospital
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Green Bay Oncology - Iron Mountain
      • Jackson, Michigan, Forenede Stater, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49001
        • Borgess Medical Center
      • Lansing, Michigan, Forenede Stater, 48912
        • Sparrow Hospital
      • Livonia, Michigan, Forenede Stater, 48154
        • Saint Mary Mercy Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Muskegon, Michigan, Forenede Stater, 49442
        • Mercy Health Partners-Hackley Campus
      • Petoskey, Michigan, Forenede Stater, 49770
        • McLaren-Northern Michigan
      • Pontiac, Michigan, Forenede Stater, 48341
        • Saint Joseph Mercy Oakland
      • Port Huron, Michigan, Forenede Stater, 48060
        • Saint Joseph Mercy Port Huron
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saginaw, Michigan, Forenede Stater, 48601
        • Saint Mary's of Michigan
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Hospital
      • Southfield, Michigan, Forenede Stater, 48075
        • Providence Hospital-Southfield Cancer Center
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forenede Stater, 48093
        • Saint John Macomb-Oakland Hospital
      • Wyoming, Michigan, Forenede Stater, 49519
        • Metro Health Hospital
    • Minnesota
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • University of Minnesota Medical Center-Fairview
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • Hubert H Humphrey Cancer Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Metro-Minnesota NCI Community Oncology Research Program
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology and Hematology PA-Woodbury
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • Saint Dominic-Jackson Memorial Hospital
      • Pascagoula, Mississippi, Forenede Stater, 39581
        • Singing River Hospital
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63701
        • Southeast Missouri Hospital
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Independence, Missouri, Forenede Stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forenede Stater, 65101
        • Capital Regional Medical Center
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Cancer Institute
      • Kansas City, Missouri, Forenede Stater, 64114
        • Saint Joseph Health Center
      • Kansas City, Missouri, Forenede Stater, 64114
        • Radiation Oncology Practice Corporation South
      • Kansas City, Missouri, Forenede Stater, 64154
        • Radiation Oncology Practice Corporation - North
      • Liberty, Missouri, Forenede Stater, 64068
        • Liberty Radiation Oncology Center
      • Liberty, Missouri, Forenede Stater, 64068
        • Liberty Hospital
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • Saint Louis, Missouri, Forenede Stater, 63110
        • Saint Louis University Hospital
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, Forenede Stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Saint Louis-Cape Girardeau CCOP
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Center for Cancer Care and Research
      • Springfield, Missouri, Forenede Stater, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59101
        • Northern Rockies Radiation Oncology Center
      • Billings, Montana, Forenede Stater, 59101
        • Montana Cancer Consortium CCOP
      • Billings, Montana, Forenede Stater, 59102
        • Frontier Cancer Center and Blood Institute-Billings
      • Billings, Montana, Forenede Stater, 59107
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59107
        • Deaconess Medical Center
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Cancer Center
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Great Falls, Montana, Forenede Stater, 59405
        • Berdeaux, Donald MD (UIA Investigator)
      • Great Falls, Montana, Forenede Stater, 59405
        • Big Sky Oncology
      • Havre, Montana, Forenede Stater, 59501
        • Northern Montana Hospital
      • Helena, Montana, Forenede Stater, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forenede Stater, 59901
        • Glacier Oncology PLLC
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Medical Oncology
      • Missoula, Montana, Forenede Stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59804
        • Guardian Oncology and Center for Wellness
      • Missoula, Montana, Forenede Stater, 59801
        • Community Medical Hospital
      • Missoula, Montana, Forenede Stater, 59802
        • Montana Cancer Specialists
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Nebraska Cancer Research Center
      • Omaha, Nebraska, Forenede Stater, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, Forenede Stater, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68131
        • Creighton University Medical Center
      • Omaha, Nebraska, Forenede Stater, 68106
        • Missouri Valley Cancer Consortium
    • Nevada
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89502
        • Center of Hope at Renown Medical Center
    • New Hampshire
      • Exeter, New Hampshire, Forenede Stater, 03833
        • Exeter Hospital
      • Keene, New Hampshire, Forenede Stater, 03431
        • Cheshire Medical Center-Dartmouth-Hitchcock Keene
      • Lebanon, New Hampshire, Forenede Stater, 03756
        • Dartmouth Hitchcock Medical Center
      • Rochester, New Hampshire, Forenede Stater, 03867
        • Frisbie Hospital
    • New Jersey
      • Brick, New Jersey, Forenede Stater, 08724
        • Ocean Medical Center
      • Camden, New Jersey, Forenede Stater, 08103
        • Cooper Hospital University Medical Center
      • Hackensack, New Jersey, Forenede Stater, 07601
        • Hackensack University Medical Center
      • Hackensack, New Jersey, Forenede Stater, 07601
        • Hackensack University Medical CCOP
      • Hackensack, New Jersey, Forenede Stater, 07601
        • Northern New Jersey CCOP
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Monmouth Medical Center
      • Morristown, New Jersey, Forenede Stater, 07960
        • Morristown Medical Center
      • Mount Holly, New Jersey, Forenede Stater, 08060
        • Fox Chase Cancer Center at Virtua Memorial Hospital of Burlington County
      • Neptune, New Jersey, Forenede Stater, 07753
        • Jersey Shore Medical Center
      • Newark, New Jersey, Forenede Stater, 07103
        • UMDNJ - New Jersey Medical School
      • Red Bank, New Jersey, Forenede Stater, 07701
        • Riverview Medical Center/Booker Cancer Center
      • Summit, New Jersey, Forenede Stater, 07902
        • Overlook Hospital
      • Toms River, New Jersey, Forenede Stater, 08755
        • Community Medical Center
      • Voorhees, New Jersey, Forenede Stater, 08043
        • Virtua West Jersey Hospital Voorhees
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Southwest Gynecologic Oncology Associates Inc
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • University of New Mexico Cancer Center
    • New York
      • Albany, New York, Forenede Stater, 12208
        • Women's Cancer Care Associates LLC
      • Brightwaters, New York, Forenede Stater, 11718
        • Island Gynecologic Oncology
      • Brooklyn, New York, Forenede Stater, 11203
        • State University of New York Downstate Medical Center
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Jamaica, New York, Forenede Stater, 11432
        • Queens Hospital Center
      • Manhasset, New York, Forenede Stater, 11030
        • North Shore University Hospital
      • Middletown, New York, Forenede Stater, 10940
        • Orange Regional Medical Center
      • New Hyde Park, New York, Forenede Stater, 11040
        • Long Island Jewish Medical Center
      • New Hyde Park, New York, Forenede Stater, 11040
        • North Shore-LIJ Health System/Center for Advanced Medicine
      • New York, New York, Forenede Stater, 10032
        • Columbia University Medical Center
      • New York, New York, Forenede Stater, 10065
        • Memorial Sloan-Kettering Cancer Center
      • New York, New York, Forenede Stater, 10029
        • Mount Sinai Medical Center
      • New York, New York, Forenede Stater, 10016
        • Laura and Issac Perlmutter Cancer Center at NYU Langone
      • Stony Brook, New York, Forenede Stater, 11794
        • Stony Brook University Medical Center
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
      • Syracuse, New York, Forenede Stater, 13203
        • Saint Joseph's Hospital Health Center
      • West Islip, New York, Forenede Stater, 11795
        • Good Samaritan Hospital Medical Center
    • North Carolina
      • Asheboro, North Carolina, Forenede Stater, 27203
        • Randolph Hospital
      • Asheville, North Carolina, Forenede Stater, 28816
        • Hope Women's Cancer Centers-Asheville
      • Burlington, North Carolina, Forenede Stater, 27216
        • Cone Health Cancer Center at Alamance Regional
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • University of North Carolina at Chapel Hill
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forenede Stater, 28204
        • Novant Health Presbyterian Medical Center
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke University Medical Center
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Memorial Hospital
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Radiation Oncology
      • Greensboro, North Carolina, Forenede Stater, 27403
        • Cone Health Cancer Center
      • Greenville, North Carolina, Forenede Stater, 27834
        • Gynecologic Oncology Network
      • Kinston, North Carolina, Forenede Stater, 28501
        • Kinston Medical Specialists PA
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth of the Carolinas-Moore Regional Hosiptal
      • Reidsville, North Carolina, Forenede Stater, 27320
        • Annie Penn Memorial Hospital
      • Rutherfordton, North Carolina, Forenede Stater, 28139
        • Rutherford Hospital
      • Wilmington, North Carolina, Forenede Stater, 28401
        • New Hanover Regional Medical Center/Zimmer Cancer Center
      • Wilson, North Carolina, Forenede Stater, 27893
        • Wilson Medical Center
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Wake Forest University Health Sciences
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Novant Health Oncology Specialists
      • Winston-Salem, North Carolina, Forenede Stater, 27104
        • Southeast Cancer Consortium-Upstate NCORP
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Saint Alexius Medical Center
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44304
        • Summa Akron City Hospital/Cooper Cancer Center
      • Akron, Ohio, Forenede Stater, 44307
        • Akron General Medical Center
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Canton, Ohio, Forenede Stater, 44710
        • Aultman Health Foundation
      • Cincinnati, Ohio, Forenede Stater, 45267
        • University of Cincinnati
      • Cleveland, Ohio, Forenede Stater, 44106
        • Case Western Reserve University
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Medical Center
      • Cleveland, Ohio, Forenede Stater, 44195
        • Cleveland Clinic Foundation
      • Cleveland, Ohio, Forenede Stater, 44111
        • Cleveland Clinic Cancer Center/Fairview Hospital
      • Clyde, Ohio, Forenede Stater, 43410
        • North Coast Cancer Care-Clyde
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Health Center
      • Dayton, Ohio, Forenede Stater, 45405
        • Grandview Hospital
      • Dayton, Ohio, Forenede Stater, 45420
        • Dayton CCOP
      • Dayton, Ohio, Forenede Stater, 45428
        • Veteran Affairs Medical Center
      • Elyria, Ohio, Forenede Stater, 44035
        • Hematology Oncology Center Incorporated
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Hospital
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Fremont, Ohio, Forenede Stater, 43420
        • Fremont Memorial Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Maumee, Ohio, Forenede Stater, 43537
        • Saint Luke's Hospital
      • Mayfield Heights, Ohio, Forenede Stater, 44124
        • Hillcrest Hospital Cancer Center
      • Mentor, Ohio, Forenede Stater, 44060
        • Lake University Ireland Cancer Center
      • Oregon, Ohio, Forenede Stater, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care
      • Sandusky, Ohio, Forenede Stater, 44870
        • Firelands Regional Medical Center
      • Sylvania, Ohio, Forenede Stater, 43560
        • Flower Hospital
      • Tiffin, Ohio, Forenede Stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forenede Stater, 43608
        • Saint Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forenede Stater, 43614
        • University of Toledo
      • Toledo, Ohio, Forenede Stater, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Toledo, Ohio, Forenede Stater, 43606
        • The Toledo Hospital/Toledo Children's Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Saint Anne Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
      • Wilmington, Ohio, Forenede Stater, 45177
        • Clinton Memorial Hospital
      • Xenia, Ohio, Forenede Stater, 45385
        • Greene Memorial Hospital
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Tulsa Cancer Institute
      • Tulsa, Oklahoma, Forenede Stater, 74104
        • Cancer Care Associates-Midtown
    • Oregon
      • Coos Bay, Oregon, Forenede Stater, 97420
        • Bay Area Hospital
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health and Science University
      • Portland, Oregon, Forenede Stater, 97210
        • Legacy Good Samaritan Hospital and Medical Center
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente
      • Portland, Oregon, Forenede Stater, 97227
        • Compass Oncology Rose Quarter
    • Pennsylvania
      • Abington, Pennsylvania, Forenede Stater, 19001
        • Abington Memorial Hospital
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bryn Mawr, Pennsylvania, Forenede Stater, 19010
        • Bryn Mawr Hospital
      • Ephrata, Pennsylvania, Forenede Stater, 17522
        • Ephrata Cancer Center
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Lancaster, Pennsylvania, Forenede Stater, 17604
        • Lancaster General Hospital
      • Media, Pennsylvania, Forenede Stater, 19063
        • Riddle Memorial Hospital
      • Paoli, Pennsylvania, Forenede Stater, 19301
        • Paoli Memorial Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19104
        • University of Pennsylvania/Abramson Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Pennsylvania Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19118
        • Chestnut Hill Health System
      • Pittsburgh, Pennsylvania, Forenede Stater, 15224
        • West Penn Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • UPMC-Magee Womens Hospital
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Scranton Hematology Oncology
      • Scranton, Pennsylvania, Forenede Stater, 18501
        • Mercy Hospital
      • Scranton, Pennsylvania, Forenede Stater, 18508
        • Hematology and Oncology Associates of North East Pennsylvania
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Lankenau Medical Center
      • Wynnewood, Pennsylvania, Forenede Stater, 19096
        • Mainline Health CCOP
      • York, Pennsylvania, Forenede Stater, 17403
        • WellSpan Health-York Cancer Center
      • York, Pennsylvania, Forenede Stater, 17405
        • WellSpan Health-York Hospital
    • Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02905
        • Women and Infants Hospital
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Health Hospital
      • Charleston, South Carolina, Forenede Stater, 29425
        • Medical University of South Carolina
      • Greenville, South Carolina, Forenede Stater, 29615
        • Greenville Health System Cancer Institute-Eastside
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Black Hills Obstetrics and Gynecology
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center-Oncology Clinic
    • Tennessee
      • Chattanooga, Tennessee, Forenede Stater, 37403
        • Chattanooga's Program In Women's Oncology
      • Chattanooga, Tennessee, Forenede Stater, 37403
        • Chattanooga Gynecological Oncology
      • Johnson City, Tennessee, Forenede Stater, 37614-0054
        • East Tennessee State University
      • Knoxville, Tennessee, Forenede Stater, 37920
        • Knoxville Gynecologic Cancer Specialists PC
      • Memphis, Tennessee, Forenede Stater, 38103
        • University of Tennesee Health Science Center
      • Nashville, Tennessee, Forenede Stater, 37232
        • Vanderbilt University/Ingram Cancer Center
      • Nashville, Tennessee, Forenede Stater, 37208
        • Meharry Medical College
    • Texas
      • Amarillo, Texas, Forenede Stater, 79106
        • The Don and Sybil Harrington Cancer Center
      • Fort Sam Houston, Texas, Forenede Stater, 78234
        • Brooke Army Medical Center
      • Galveston, Texas, Forenede Stater, 77555-0565
        • University of Texas Medical Branch
      • Houston, Texas, Forenede Stater, 77030
        • M D Anderson Cancer Center
      • Lubbock, Texas, Forenede Stater, 79430
        • Texas Tech University Health Sciences Center
      • Temple, Texas, Forenede Stater, 76508
        • Scott and White Memorial Hospital
    • Utah
      • American Fork, Utah, Forenede Stater, 84003
        • American Fork Hospital
      • Cedar City, Utah, Forenede Stater, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forenede Stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forenede Stater, 84107
        • Cottonwood Hospital Medical Center
      • Murray, Utah, Forenede Stater, 84157
        • Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center
      • Saint George, Utah, Forenede Stater, 84770
        • Dixie Medical Center Regional Cancer Center
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84143
        • LDS Hospital
      • Salt Lake City, Utah, Forenede Stater, 84103
        • Intermountain Health Care
    • Vermont
      • Burlington, Vermont, Forenede Stater, 05401
        • University of Vermont Medical Center
    • Virginia
      • Annandale, Virginia, Forenede Stater, 22003
        • Northern Virginia Pelvic Surgery Associates
      • Charlottesville, Virginia, Forenede Stater, 22908
        • University of Virginia Cancer Center
      • Danville, Virginia, Forenede Stater, 24541
        • Danville Regional Medical Center
      • Fairfax, Virginia, Forenede Stater, 22033
        • Kaiser Permanente - Fair Oaks Medical Center
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Fredericksburg Oncology Inc
      • Kilmarnock, Virginia, Forenede Stater, 22482
        • Rappahannock General Hospital
      • Newport News, Virginia, Forenede Stater, 23602
        • Bon Secours Mary Immaculate Hospital
      • Norfolk, Virginia, Forenede Stater, 23502
        • Virginia Oncology Associates - Lake Wright
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
      • Roanoke, Virginia, Forenede Stater, 24016
        • Carilion Clinic Gynecological Oncology
    • Washington
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Centralia, Washington, Forenede Stater, 98531
        • Providence Regional Cancer System-Centralia
      • Federal Way, Washington, Forenede Stater, 98003
        • Saint Francis Hospital
      • Lakewood, Washington, Forenede Stater, 98499
        • Saint Clare Hospital
      • Olympia, Washington, Forenede Stater, 98506-5166
        • Providence - Saint Peter Hospital
      • Olympia, Washington, Forenede Stater, 98507
        • Capital Medical Center
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Seattle, Washington, Forenede Stater, 98195
        • University of Washington Medical Center
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
      • Seattle, Washington, Forenede Stater, 98101
        • Virginia Mason CCOP
      • Tacoma, Washington, Forenede Stater, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, Forenede Stater, 98431
        • Madigan Army Medical Center
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Allenmore Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • Saint Joseph Medical Center
      • Tacoma, Washington, Forenede Stater, 98415
        • MultiCare Health System
      • Tacoma, Washington, Forenede Stater, 98405
        • Northwest CCOP
    • Wisconsin
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Sacred Heart Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology Limited at Saint Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54311-6519
        • Aurora BayCare Medical Center
      • Madison, Wisconsin, Forenede Stater, 53792
        • University of Wisconsin Hospital and Clinics
      • Madison, Wisconsin, Forenede Stater, 53717
        • Dean Hematology and Oncology Clinic
      • Manitowoc, Wisconsin, Forenede Stater, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Bay Area Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Saint Joseph's Hospital
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Froedtert and The Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Medical Consultants Limited
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Oconomowoc Memorial Hospital-ProHealth Care Inc
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Green Bay Oncology - Oconto Falls
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Marshfield Clinic at James Beck Cancer Center
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Clinic-Rice Lake Center
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Slinger, Wisconsin, Forenede Stater, 53086
        • Vince Lombardi Cancer Clinic - Slinger
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology - Sturgeon Bay
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Waukesha Memorial Hospital
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic - Weston Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
    • Wyoming
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center
  • Japan
      • Kobe, Japan, 654-0155
        • National Hospital Organization-Kobe Medical Center
      • Matsuyama, Japan, 791-0280
        • Shikoku Cancer Center
      • Saitama, Japan, 350-1298
        • Saitama Medical University International Medical Center
      • Tokyo, Japan, 104 0045
        • National Cancer Center Hospital
      • Tottori, Japan, 680-8550
        • Tottori University
    • Aoba-ku
      • Sendai, Aoba-ku, Japan, 980-8574
        • Tohoku University School of Medicine
    • Hiroshima
      • Kure, Hiroshima, Japan, 737
        • Kure National Hospital
    • Iwate
      • Morioka, Iwate, Japan, 020-8505
        • Iwate Medical University School of Medicine
    • Kagoshima
      • Kagoshima City, Kagoshima, Japan, 890-8760
        • Kagoshima City Hospital
    • Tokyo
      • Shinjuku-ku, Tokyo, Japan, 160-8582
        • Keio University
  • Korea, Republikken
      • Seoul, Korea, Republikken, 138-736
        • Asan Medical Center
      • Seoul, Korea, Republikken, 110-744
        • Seoul National University Hospital
      • Seoul, Korea, Republikken, 139-706
        • Korea Cancer Center Hospital
      • Seoul, Korea, Republikken, 135-720
        • Yongdong Severence Hospital
      • Suwon, Korea, Republikken, 443-721
        • Ajou University Hospital
      • Youngdungpo-gu, Korea, Republikken, 150-071
        • KangNam Sacred Heart Hospital
    • Korea
      • Seoul, Korea, Korea, Republikken, 135-710
        • Samsung Medical Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

Inklusionskriterier:

  • Patienter med en histologisk diagnose af epitelial ovariecancer, peritoneal primær carcinom eller æggeledercancer; International Federation of Gynecology and Obstetrics (FIGO) stadium III med enhver grov (makroskopisk eller palpabel) resterende sygdom eller FIGO stadium IV, defineret kirurgisk ved afslutningen af ​​den indledende abdominale operation og med passende væv tilgængeligt til histologisk evaluering; den mindst nødvendige operation var en abdominal operation, der gav væv til histologisk evaluering og etablering og dokumentation af det primære sted og stadie, samt en maksimal indsats for at fjerne tumorer; hvis yderligere kirurgi blev udført, skulle det have været i overensstemmelse med passende kirurgi for ovarie- eller peritonealcarcinom beskrevet i Gynecologic Oncology Group (GOG) Surgical Procedures Manual; det kræves dog ikke, at kirurgen har udført alle de punkter, der er indeholdt i dette afsnit af GOG Surgical Procedures Manual; de patienter med stadium III cancer, hvor den største maksimale diameter af ethvert resterende tumorimplantat ved afslutningen af ​​denne indledende operation ikke er større end 1 cm, vil blive defineret som "optimal;" alle andre vil blive defineret som "suboptimale;" målbar sygdom på postoperative billeddiagnostiske undersøgelser er ikke påkrævet for berettigelse
  • Patienter med følgende histologiske epitelcelletyper er kvalificerede: serøst adenokarcinom, endometrioid adenokarcinom, mucinøst adenokarcinom, udifferentieret carcinom, klarcellet adenokarcinom, blandet epitelcarcinom, overgangscellecarcinom, malignt Brenners tumor, eller aden.Socarcinom på anden måde (N.Socarcinom.O); tumorens histologiske træk skal imidlertid være forenelige med et primært Müllerian epiteliale adenokarcinom; hvis der er tvivl, anbefales det, at investigatoren skal få slides gennemgået af en uafhængig patolog eller, om nødvendigt, patologiens medformand, før indrejsen; patienter kan have co-eksisterende æggeledercarcinom in situ, så længe den primære oprindelse af invasiv tumor er ovarie-, peritoneal- eller æggeleder
  • Absolut neutrofiltal (ANC) større end eller lig med 1.500/µl svarende til almindelige toksicitetskriterier for bivirkninger version (v)3.0 (CTCAE) grad 1; denne ANC kan ikke være blevet induceret eller understøttet af granulocytkolonistimulerende faktorer
  • Blodplader større end eller lig med 100.000/µl; (CTCAE klasse 0-1)
  • Kreatinin =< 1,5 x institutionel øvre grænse normal (ULN), CTCAE grad 1
  • Bilirubin mindre end eller lig med 1,5 x ULN (CTCAE grad 1)
  • Serum glutaminsyre oxaloeddikesyre transaminase (SGOT) og alkalisk fosfatase mindre end eller lig med 2,5 x ULN (CTCAE grad 1)
  • Neuropati (sensorisk og motorisk) mindre end eller lig med CTCAE grad 1
  • Protrombintid (PT), således at international normaliseret ratio (INR) er =< 1,5 (eller en INR inden for området, sædvanligvis mellem 2 og 3, hvis en patient er på en stabil dosis af terapeutisk warfarin til håndtering af venøs trombose inklusive pulmonal trombose -emboli) og en partiel tromboplastintid (PTT) < 1,2 gange den øvre grænse for normalen
  • Patienter med en GOG Performance Status på 0, 1 eller 2
  • Patienter skal indtastes mellem 1 og 12 uger efter indledende operation udført med det kombinerede formål diagnose, stadieinddeling og cytoreduktion
  • Patienter med målbar og ikke-målbar sygdom er kvalificerede; patienter kan have eller ikke har kræftrelaterede symptomer
  • Patienter, der har opfyldt før-adgangskravene
  • Et godkendt informeret samtykke og autorisation, der tillader frigivelse af personlige helbredsoplysninger, skal underskrives af patienten eller værgen
  • Patienter i dette forsøg kan modtage ovarieøstrogen +/- progestinerstatningsterapi som angivet ved den eller de laveste effektive dosis(er) til kontrol af menopausale symptomer til enhver tid, men ikke progestiner til behandling af anoreksi, mens de er i protokolstyret behandling eller før sygdomsprogression

Ekskluderingskriterier:

  • Patienter med en aktuel diagnose af borderline epitelial ovarietumor (tidligere "tumorer med lavt malignt potentiale") eller tilbagevendende invasiv epitelial ovarie-, primær peritoneal- eller æggeledercancer behandlet kun med kirurgi (såsom patienter med stadium Ia eller Ib lavgradig epitelial ovarie- eller æggelederkræft) er ikke kvalificerede; patienter med en tidligere diagnose af en borderlinetumor, der er blevet kirurgisk resekeret, og som efterfølgende udvikler en ikke-relateret, ny invasiv epitelial ovarie-, peritoneal primær eller æggeledercancer er berettigede, forudsat at de ikke tidligere har modtaget kemoterapi for nogen ovarietumor
  • Patienter, der tidligere har modtaget strålebehandling af en hvilken som helst del af bughulen eller bækkenet, er udelukket; forudgående stråling for lokaliseret kræft i bryst, hoved og hals eller hud er tilladt, forudsat at den er gennemført mere end tre år før registreringen, og patienten forbliver fri for tilbagevendende eller metastatisk sygdom
  • Patienter, der tidligere har modtaget kemoterapi for enhver abdominal eller bækkentumor, inklusive neo-adjuverende kemoterapi for deres ovarie-, primære peritoneal- eller æggeledercancer, er udelukket; patienter kan have modtaget forudgående adjuverende kemoterapi for lokaliseret brystkræft, forudsat at den er afsluttet mere end tre år før registreringen, og at patienten forbliver fri for tilbagevendende eller metastatisk sygdom
  • Patienter, der har modtaget målrettet behandling (herunder, men ikke begrænset til, vacciner, antistoffer, tyrosinkinasehæmmere) eller hormonbehandling til behandling af deres epiteliale ovarie- eller peritoneal primær cancer
  • Patienter med synkron primær endometriecancer eller en tidligere historie med primær endometriecancer er udelukket, medmindre alle følgende betingelser er opfyldt: stadium ikke større end I-B; ikke mere end overfladisk myometrial invasion, uden vaskulær eller lymfatisk invasion; ingen dårligt differentierede undertyper, inklusive papillære serøse, klare celler eller andre FIGO grad 3 læsioner
  • Med undtagelse af ikke-melanom hudkræft og andre specifikke maligniteter som nævnt ovenfor, er patienter med andre invasive maligne sygdomme, som havde (eller har) tegn på den anden kræftsygdom til stede inden for de sidste fem år, eller hvis tidligere kræftbehandling kontraindikerer denne protokolbehandling. udelukket
  • Patienter med akut hepatitis eller aktiv infektion, der kræver parenterale antibiotika
  • Patienter med alvorlige ikke-helende sår, mavesår eller knoglebrud; dette omfatter anamnese med abdominal fistel, gastrointestinal perforation eller intraabdominal absces inden for 28 dage; patienter med granulerende snit, der heler af sekundær hensigt uden tegn på fascial dehiscens eller infektion er kvalificerede, men kræver ugentlige sårundersøgelser
  • Patienter med aktiv blødning eller patologiske tilstande, der medfører høj risiko for blødning, såsom kendt blødningsforstyrrelse, koagulopati eller tumor, der involverer større kar
  • Patienter med anamnese eller bevis efter fysisk undersøgelse af sygdom i centralnervesystemet (CNS), inklusive primær hjernetumor, anfald, der ikke er kontrolleret med standard medicinsk behandling, eventuelle hjernemetastaser eller historie med cerebrovaskulær ulykke (CVA, slagtilfælde), forbigående iskæmisk anfald (TIA) ) eller subaraknoidal blødning inden for seks måneder efter den første behandlingsdato i denne undersøgelse
  • Patienter med klinisk signifikant kardiovaskulær sygdom; dette inkluderer:
  • Ukontrolleret hypertension, defineret som systolisk > 150 mm Hg eller diastolisk > 90 mm Hg
  • Myokardieinfarkt eller ustabil angina < 6 måneder før registrering
  • New York Heart Association (NYHA) grad II eller større kongestiv hjertesvigt
  • Alvorlig hjertearytmi, der kræver medicin; dette inkluderer ikke asymptomatisk atrieflimren med kontrolleret ventrikulær frekvens
  • CTCAE grad 2 eller større perifer vaskulær sygdom (mindst korte (< 24 timer) episoder af iskæmi styret ikke-kirurgisk og uden permanent underskud)
  • Historie af CVA inden for seks måneder
  • Patienter med kendt overfølsomhed over for kinesisk hamster-ovariecelleprodukter eller andre rekombinante humane eller humaniserede antistoffer
  • Patienter med klinisk signifikant proteinuri; urinprotein bør screenes ved urinprotein-kreatinin ratio (UPCR); UPCR har vist sig at korrelere direkte med mængden af ​​protein, der udskilles i en 24 timers urinopsamling; specifikt svarer en UPCR på 1,0 til 1,0 gram protein i en 24 timers urinopsamling; opnå mindst 4 ml af en tilfældig urinprøve i en steril beholder (behøver ikke at være en 24 timers urin); send prøve til laboratoriet med anmodning om urinprotein og kreatininniveauer [særskilte anmodninger]; laboratoriet vil måle proteinkoncentration (mg/dL) og kreatininkoncentration (mg/dL); UPCR er afledt som følger: proteinkoncentration (mg/dL)/creatinin (mg/dL); patienter skal have en UPCR < 1,0 for at tillade deltagelse i undersøgelsen
  • Patienter med eller med forventning om invasive procedurer som defineret nedenfor:
  • Større kirurgisk indgreb, åben biopsi eller betydelig traumatisk skade inden for 28 dage før den første dato for bevacizumab/placebobehandling (cyklus 2)
  • Større kirurgisk indgreb, der forventes i løbet af undersøgelsen; dette omfatter, men er ikke begrænset til abdominal kirurgi (laparotomi eller laparoskopi) forud for sygdomsprogression, såsom colostomi eller enterostomi reversering, interval eller sekundær cytoreduktiv kirurgi, eller second look-kirurgi; rådfør dig med studielederen inden patientens indtræden for spørgsmål vedrørende klassificeringen af ​​kirurgiske indgreb
  • Kernebiopsi, inden for 7 dage før den første dato for bevacizumab/placebobehandling (cyklus 2)
  • Patienter med GOG Performance Grade på 3 eller 4
  • Patienter, der er gravide eller ammer; bevacizumab bør ikke administreres til ammende kvinder; patienter i den fødedygtige alder skal acceptere at bruge prævention under studiebehandlingen og i mindst seks måneder efter afslutningen af ​​bevacizumab-behandlingen
  • Patienter, der tidligere har modtaget behandling med et lægemiddel mod vaskulær endotelvækstfaktor (VEGF), inklusive bevacizumab
  • Patienter med kliniske symptomer eller tegn på gastrointestinal obstruktion, og som kræver parenteral hydrering og/eller ernæring
  • Patienter med sygehistorie eller tilstande, som ikke på anden måde tidligere er specificeret, og som efter investigators mening bør udelukke deltagelse i denne undersøgelse; investigator bør være velkommen til at konsultere studielederen eller studielederne for usikkerhed i denne henseende

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Dobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Arm I (placebo, paclitaxel, carboplatin)
Patienterne får paclitaxel IV over 3 timer og carboplatin IV over 30 minutter på dag 1. Fra kursus 2 får patienterne også placebo IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb. Begyndende i kursus 7 får patienter placebo alene IV over 30-90 minutter på dag 1. Behandling med placebo gentages hver 21. dag i op til 22 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Medicin: Carboplatin
Givet IV
Andre navne:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatin
  • Paraplatin
  • Paraplatin AQ
  • Platinwas
  • Ribocarbo
  • Paraplat
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Medicin: Paclitaxel
Givet IV
Andre navne:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat
Andet: Placebo
Givet IV
Andre navne:
  • placebo terapi
  • PLCB
  • falsk terapi
Eksperimentel: Arm II (placebo, paclitaxel, carboplatin, bevacizumab)
Patienterne får paclitaxel og carboplatin som i arm I. Fra og med forløb 2 får patienterne også bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb. Begyndende i kursus 7 får patienter placebo alene IV over 30-90 minutter på dag 1. Behandling med placebo gentages hver 21. dag i op til 22 kure i fravær af sygdomsprogression eller uacceptabel toksicitet.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Medicin: Carboplatin
Givet IV
Andre navne:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatin
  • Paraplatin
  • Paraplatin AQ
  • Platinwas
  • Ribocarbo
  • Paraplat
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Medicin: Paclitaxel
Givet IV
Andre navne:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat
Biologisk: Bevacizumab
Givet IV
Andre navne:
  • Avastin
  • Anti-VEGF
  • Anti-VEGF humaniseret monoklonalt antistof
  • Anti-VEGF rhuMAb
  • Bevacizumab Biosimilar BEVZ92
  • Bevacizumab Biosimilar BI 695502
  • Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer
  • Rekombinant humaniseret anti-VEGF monoklonalt antistof
  • rhuMab-VEGF
Andet: Placebo
Givet IV
Andre navne:
  • placebo terapi
  • PLCB
  • falsk terapi
Eksperimentel: Arm III (paclitaxel, carboplatin, bevacizumab)
Patienterne får paclitaxel og carboplatin som i arm I. Fra og med forløb 2 får patienterne også bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gentages hver 21. dag i 6 forløb. Fra kursus 7 får patienterne bevacizumab alene IV over 30-90 minutter på dag 1. Behandling med bevacizumab gentages hver 21. dag i op til 22 behandlingsforløb i fravær af sygdomsprogression eller uacceptabel toksicitet.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Medicin: Carboplatin
Givet IV
Andre navne:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatin
  • Paraplatin
  • Paraplatin AQ
  • Platinwas
  • Ribocarbo
  • Paraplat
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Medicin: Paclitaxel
Givet IV
Andre navne:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat
Biologisk: Bevacizumab
Givet IV
Andre navne:
  • Avastin
  • Anti-VEGF
  • Anti-VEGF humaniseret monoklonalt antistof
  • Anti-VEGF rhuMAb
  • Bevacizumab Biosimilar BEVZ92
  • Bevacizumab Biosimilar BI 695502
  • Immunoglobulin G1 (human-mus monoklonal rhuMab-VEGF gammakæde anti-human vaskulær endotelvækstfaktor), disulfid med human-mus monoklonal rhuMab-VEGF let kæde, dimer
  • Rekombinant humaniseret anti-VEGF monoklonalt antistof
  • rhuMab-VEGF

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Progressionsfri overlevelse
Tidsramme: Fra studiestart til første sygdomsprogression, død eller dato for sidste kontakt, op til 6 år
Median progressionsfri overlevelse (PFS). Begyndelse af progression kan være baseret på radiografiske (RECIST) kriterier eller stigende CA-125 (GCIG-kriterier).
Fra studiestart til første sygdomsprogression, død eller dato for sidste kontakt, op til 6 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Samlet overlevelse
Tidsramme: Fra studiestart til død eller sidste kontakt, op til 6 år
Median samlet overlevelse (OS)
Fra studiestart til død eller sidste kontakt, op til 6 år
Hyppighed og sværhedsgrad (grad 3 eller derover) af uønskede hændelser vurderet ved almindelige terminologikriterier for uønskede hændelser Version 3.0
Tidsramme: Op til 5 år
Kvalificerede og evaluerbare patienter
Op til 5 år
Indvirkning på livskvalitet målt ved den funktionelle vurdering af udfaldsindeks for kræftterapi-æggestokkeforsøg (FACT-O TOI)
Tidsramme: Ved baseline, 9, 18, 36, 60 og 84 uger
Estimerede mindste kvadraters gennemsnit fra et blandet modul af livskvalitetsscore (QOL) ved hvert vurderingspunkt, justeret for baseline-score og patientens alder. Bemærk: Rækken af ​​mulige scores for FACT-O TOI er 0 - 104 for alle behandlingsgrupper og ved alle besøg. En højere score indikerer bedre QOL. Baseline-gennemsnitsscore er råmiddelværdier.
Ved baseline, 9, 18, 36, 60 og 84 uger

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Samarbejdspartnere

NRG Oncology

Efterforskere

  • Ledende efterforsker: Robert Burger, NRG Oncology

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart

1. september 2005

Primær færdiggørelse (Faktiske)

1. november 2010

Studieafslutning (Faktiske)

1. april 2015

Datoer for studieregistrering

Først indsendt

6. december 2005

Først indsendt, der opfyldte QC-kriterier

6. december 2005

Først opslået (Skøn)

7. december 2005

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

23. juli 2019

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

19. juli 2019

Sidst verificeret

1. juli 2019

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NCI-2009-00590 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • U10CA180868 (U.S. NIH-bevilling/kontrakt)
  • U10CA027469 (U.S. NIH-bevilling/kontrakt)
  • CDR0000455114
  • GOG-0218 (Anden identifikator: CTEP)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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