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Hormonterapi med eller uden kombinationskemoterapi til behandling af kvinder, der er blevet opereret for node-negativ brystkræft (TAILORx-forsøget) (TAILORx)

4. september 2026 opdateret af: National Cancer Institute (NCI)

Program til vurdering af kliniske kræfttest (PACCT-1): Forsøg, der tildeler individualiserede behandlingsmuligheder: TAILORx-forsøget

Dette randomiserede fase III-forsøg undersøger den bedste individuelle behandling for kvinder, der har node-negativ, østrogen-receptor positiv brystkræft ved at bruge en speciel test (Oncotype DX), og om hormonbehandling alene eller hormonbehandling sammen med kombinationskemoterapi er bedre for kvinder som har en Oncotype DX-gentagelsesscore på 11-25. Østrogen kan forårsage vækst af brystkræftceller. Hormonbehandling kan bekæmpe brystkræft ved at blokere for brugen af østrogen i tumorcellerne eller ved at sænke mængden af østrogen, som kroppen producerer. Lægemidler, der bruges i kemoterapi, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. At give hormonbehandling sammen med mere end ét kemoterapilægemiddel (kombinationskemoterapi) har vist sig at reducere chancen for tilbagefald af brystkræft, men fordelen ved at tilføje kemoterapi til hormonbehandling for kvinder med node-negativ, østrogen-receptor positiv brystkræft er lille. . Nye test kan give information om, hvilke patienter der er mere tilbøjelige til at få gavn af kemoterapi.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At bestemme, om adjuverende hormonbehandling ikke er ringere end adjuverende kemohormonal hos kvinder, hvis tumorer opfylder etablerede kliniske retningslinjer for adjuverende kemoterapi og falder i kategorien "primær undersøgelsesgruppe" (Oncotype DX Recidiv Score 11-25).

II. At skabe en vævs- og prøvebank for patienter, der er tilmeldt dette forsøg, inklusive formalinfikserede paraffinindlejrede tumorprøver, vævsmikroarrays, plasma og deoxyribonukleinsyre (DNA) opnået fra perifert blod.

SEKUNDÆRE MÅL:

I. At bestemme, om adjuverende hormonbehandling er tilstrækkelig behandling (dvs. 10 års fjern sygdomsfri overlevelse på mindst 95%) for kvinder, hvis tumorer opfylder etablerede kliniske retningslinjer for adjuverende kemoterapi, og som falder ind under kategorien "Sekundær undersøgelsesgruppe-1" (Oncotype DX-gentagelsesscore =< 10).

II. At sammenligne de resultater, der er projekteret efter 10 år af adjuvans (med resultater, der er fremskrevet ved hjælp af klassisk patologisk information, herunder tumorstørrelse, hormonreceptorstatus og histologisk karakter) med resultaterne lavet af Genomic Health Oncotype DX-testen. Klassisk patologisk information og resultater vil også blive brugt til at skabe og forfine modeller, der ville bruge klassisk information i stedet for eller i kombination med genomiske test.

III. At estimere fejlrater som en funktion af recidivscore (RS) separat i kemoterapi- (arm C, D) og ingen kemoterapi (arm A, B). Formålet med analysen er at udvikle mere præcise estimater af sammenhængen mellem recidivscore og eventuel kemoterapibehandlingseffekt i det øvre område af RS 11 - 25-gruppen.

IV. For at bestemme den prognostiske betydning af Oncotype DX-gentagelsesscoren og af de individuelle RS-gengrupper (proliferationsgengruppe, human epidermal vækstfaktorreceptor [HER]2 gengruppe, østrogenreceptor [ER] gengruppe, invasionsgengruppe og andre gener ).

TERTIÆRE MÅL:

I. At evaluere virkningerne af kemoterapi og hormonbehandling vs hormonbehandling alene på opfattet kognitiv svækkelse, træthed, frygt for tilbagefald blandt præmenopausale patienter, endokrine symptomer og seksuel dysfunktion og overordnet sundhedsrelateret livskvalitet (HRQL).

II. For at afgøre, om opfattet kognitiv svækkelse, træthed, frygt for tilbagefald, endokrine symptomer og overordnet HRQL er ens for patienter, der modtager kemoterapi plus hormonbehandling i sekundær undersøgelsesgruppe 2, som for dem i den primære undersøgelsesgruppe (arm D vs C).

III. For at bestemme, om opfattet kognitiv svækkelse, træthed, frygt for tilbagefald, endokrine symptomer og overordnet HRQL er ens for patienter, der modtager hormonbehandling alene i sekundær undersøgelsesgruppe 1, som for dem i den primære undersøgelsesgruppe (arm A vs B).

IV. At afgøre, om alder vil være omvendt forbundet med en frygt for tilbagefald, uafhængigt af behandlingstildeling.

V. Blandt deltagere, der modtager hormonbehandling alene på arm A og arm B, for at bestemme, om Oncotype DX Recidivscore vil være omvendt korreleret med frygt for recidiv.

VI. At skabe et bioprøvelager inklusive plasma-, serum- og CellSearch-kassetter indeholdende cirkulerende tumorceller (CTC) til evaluering af determinanter for sent tilbagefald, herunder kandidatbiomarkører, der afspejler okkult tumorbyrde (f.eks. CTC'er og plasmatumor-DNA) og værtsfaktorer (f.eks. østrogen, insulinvækstfaktor-[IGF]-akse, inflammation osv.).

VII. At skabe et biodepot af metastatiske tumorprøver hos patienter, der har haft et sent tilbagefald.

VIII. At bestemme body mass index (BMI) og komorbiditetsbyrde hos patienter med operabel brystkræft fem eller flere år efter diagnosen.

IX. At afgøre, om der er en sammenhæng mellem sent tilbagefald og BMI ved diagnose og 5 år efter diagnose, og om BMI-associerede inflammatoriske og/eller metaboliske biomarkører er forbundet med tidligt og sent recidiv.

OVERSIGT: Dette er et delvist randomiseret studie. Patienterne inddeles i 1 ud af 3 behandlingsgrupper.

GRUPPE 1 (SEKUNDÆR UNDERSØGELSESGRUPPE 1; ONCOTYPE DX RECIURRENCESCORE [ODRS] =< 10): Patienter modtager standard hormonbehandling (f.eks. tamoxifen alene oralt (PO), aromatasehæmmer [f.eks. anastrozol, letrozol eller exemestan] alene PO, eller tamoxifen PO efterfulgt af aromatasehæmmer PO) efter den behandlende læges skøn i 5 eller 10 år.

GRUPPE 2 (PRIMÆR STUDIEGRUPPE; ODRS 11-25): Patienter randomiseres til at modtage enten hormonbehandling alene eller kombineret kemoterapi og hormonbehandling.

ARM I (EKSPERIMENTEL): Patienter modtager hormonbehandling som i gruppe 1 efter den behandlende læges skøn.

ARM II (STANDARD): Patienter modtager standard kombinationskemoterapi efter den behandlende læges skøn. Inden for 4 uger efter den sidste dosis kemoterapi modtager patienterne hormonbehandling som i gruppe 1 efter den behandlende læges skøn.

GRUPPE 3 (SEKUNDÆR STUDIEGRUPPE 2; ODRS >= 26): Patienter får kombinationskemoterapi som i gruppe 2, arm II efterfulgt af hormonbehandling som i gruppe 1.

Patienter i alle grupper, der har fået foretaget en brystbevarende operation, behandles også med strålebehandling. Strålebehandling bør påbegyndes inden for 4 uger efter registrering for patienter, der får hormonbehandling alene eller inden for 8 uger efter afslutning af kemoterapi. Patienter, der deltager i National Surgical Adjuvant Breast and Bowel Project (NSABP) og/eller Radiation Therapy Oncology Group (RTOG) delvise bestrålingsforsøg kan modtage delvis bryststråling.

Efter afsluttet undersøgelsesbehandling følges patienterne hver 3.-6. måned i 5 år og derefter årligt i 15 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

10273

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Australien
- New South Wales
  - Albury, New South Wales, Australien, 2640
    - Border Medical Oncology
  - Coffs Harbour, New South Wales, Australien, 2450
    - Coffs Harbour Health Campus-North Coast Cancer Institute
  - Concord, New South Wales, Australien, 2139
    - Concord Repatriation General Hospital
  - Lismore, New South Wales, Australien, 2480
    - Lismore Base Hospital
  - Merewether, New South Wales, Australien, 2191
    - Lingard Private Hospital
  - Newcastle, New South Wales, Australien, 2300
    - Royal Newcastle Hospital
  - Waratah, New South Wales, Australien, 2310
    - Calvary Mater Newcastle Hospital
- Queensland
  - Herston, Queensland, Australien, 4029
    - Royal Brisbane and Women's Hospital
  - Nambour, Queensland, Australien, 4560
    - Nambour Hospital
- Tasmania
  - Saint Hobart, Tasmania, Australien, 7000
    - Royal Hobart Hospital
- Victoria
  - East Melbourne, Victoria, Australien, 3002
    - Breast Unit-Mercy Private
  - Richmond, Victoria, Australien, 3121
    - Epworth Hospital
- Western Australia
  - Bunbury, Western Australia, Australien, 6230
    - Saint John of God Hospital - Bunbury
  - Nedlands, Western Australia, Australien, 6009
    - Sir Charles Gairdner Hospital
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 5G2
    - Arthur J E Child Comprehensive Cancer Centre
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - BCCA-Cancer Centre for the Southern Interior
  - Penticton, British Columbia, Canada, V2A 3G6
    - Penticton Regional Hospital
  - Surrey, British Columbia, Canada, V3V 1Z2
    - BCCA-Fraser Valley Cancer Centre
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
  - Victoria, British Columbia, Canada, V8R 6V5
    - BCCA-Vancouver Island Cancer Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - The Moncton Hospital
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Ontario
  - Greater Sudbury, Ontario, Canada, P3E 5J1
    - Health Sciences North
  - Mississauga, Ontario, Canada, L5M 2N1
    - Trillium Health Partners - Credit Valley Hospital
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Thunder Bay Regional Health Science Centre
  - Toronto, Ontario, Canada, M4N 3M5
    - Odette Cancer Centre- Sunnybrook Health Sciences Centre
  - Toronto, Ontario, Canada, M5B 1W8
    - Saint Michael's Hospital
  - Toronto, Ontario, Canada, M4C 3E7
    - Michael Garron Hospital
  - Toronto, Ontario, Canada, M9C 1A5
    - Trillium Health Partners - Queensway Health Centre
  - Windsor, Ontario, Canada, N8W 2X3
    - Windsor Regional Cancer Centre
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - CSSS Champlain-Charles Le Moyne
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital
  - Montreal, Quebec, Canada, H3H 2R9
    - The Research Institute of the McGill University Health Centre (MUHC)
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM-Hotel Dieu de Montreal
  - Montreal, Quebec, Canada, H2X 3E4
    - CHUM - Centre Hospitalier de l'Universite de Montreal
  - Montreal, Quebec, Canada, H1T 2M4
    - CIUSSSEMTL-Hopital Maisonneuve-Rosemont
  - Québec, Quebec, Canada, G1S 4L8
    - CHU de Quebec-Hopital du Saint-Sacrement (HSS)
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Det Forenede Kongerige
- Northern Ireland
  - Belfast, Northern Ireland, Det Forenede Kongerige, BT9 7AB
    - Belfast City Hospital
Forenede Stater
- Alabama
  - Anniston, Alabama, Forenede Stater, 36202
    - Northeast Alabama Regional Medical Center
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Mobile, Alabama, Forenede Stater, 36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile, Alabama, Forenede Stater, 36608
    - Providence Hospital
  - Mobile, Alabama, Forenede Stater, 36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Regional Hospital
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Glendale, Arizona, Forenede Stater, 85306
    - Banner Thunderbird Medical Center
  - Mesa, Arizona, Forenede Stater, 85202
    - Banner Desert Medical Center
  - Mesa, Arizona, Forenede Stater, 85206
    - Banner Baywood Medical Center
  - Phoenix, Arizona, Forenede Stater, 85006
    - Banner-University Medical Center Phoenix
  - Phoenix, Arizona, Forenede Stater, 85006
    - Western Regional CCOP
  - Scottsdale, Arizona, Forenede Stater, 85258
    - Virginia G Piper Cancer Care-Del Camino
  - Tucson, Arizona, Forenede Stater, 85719
    - Banner University Medical Center - Tucson
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Fort Smith, Arkansas, Forenede Stater, 72901
    - Sparks Regional Medical Center
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Baptist Memorial Hospital
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - Saint Bernards Regional Medical Center
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
- California
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Arroyo Grande, California, Forenede Stater, 93420
    - Arroyo Grande Community
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Forenede Stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forenede Stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Chico, California, Forenede Stater, 95926
    - Enloe Medical Center
  - Clovis, California, Forenede Stater, 93611
    - Community Cancer Institute
  - Concord, California, Forenede Stater, 94520
    - John Muir Medical Center-Concord
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Emeryville, California, Forenede Stater, 94608
    - Bay Area Breast Surgeons Inc
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Washington Health
  - Fresno, California, Forenede Stater, 93720
    - California Cancer Associates for Research and Excellence (cCare)
  - Fullerton, California, Forenede Stater, 92835
    - Saint Jude Medical Center
  - Glendale, California, Forenede Stater, 91204
    - Glendale Memorial Hospital and Health Center
  - Greenbrae, California, Forenede Stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forenede Stater, 94904
    - Marin General Hospital
  - Hayward, California, Forenede Stater, 94545
    - Saint Rose Hospital
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - La Jolla, California, Forenede Stater, 92037
    - Scripps Green Hospital
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Long Beach, California, Forenede Stater, 90806
    - Long Beach Memorial Medical Center-Todd Cancer Institute
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90095
    - UCLA / Jonsson Comprehensive Cancer Center
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Mission Hills, California, Forenede Stater, 91346-9600
    - Providence Holy Cross Medical Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Monterey, California, Forenede Stater, 93940
    - Community Hospital of Monterey Peninsula
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Northridge, California, Forenede Stater, 91325
    - Northridge Hospital Medical Center
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forenede Stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Tumor Institute
  - Oakland, California, Forenede Stater, 94602
    - Wilma Chan Highland Hospital
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palm Springs, California, Forenede Stater, 92262
    - Desert Regional Medical Center
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Care Health System - Pleasanton
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Medical Oncology Consultants
  - Pomona, California, Forenede Stater, 91767
    - Pomona Valley Hospital Medical Center
  - Redding, California, Forenede Stater, 96001
    - Mercy Regional Cancer Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95819
    - Mercy General Hospital
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente Sacramento Medical Center
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial
  - San Diego, California, Forenede Stater, 92134
    - Naval Medical Center -San Diego
  - San Diego, California, Forenede Stater, 92123
    - Sharp Memorial Hospital
  - San Diego, California, Forenede Stater, 92103
    - UC San Diego Medical Center - Hillcrest
  - San Diego, California, Forenede Stater, 92161
    - San Diego VA Medical Center
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente-Rio San Diego
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forenede Stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Pablo, California, Forenede Stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Ana, California, Forenede Stater, 92705
    - Breastlink Medical Group Inc
  - Santa Barbara, California, Forenede Stater, 93105
    - Cancer Center of Santa Barbara
  - Santa Barbara, California, Forenede Stater, 93105
    - Ridley-Tree Cancer Center
  - Santa Barbara, California, Forenede Stater, 93105
    - Sansum Clinic Inc
  - Santa Barbara, California, Forenede Stater, 93111
    - Ray, Margaret, Savage. M.D. (UIA Investigator)
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95405
    - Providence Santa Rosa Memorial Hospital
  - Solvang, California, Forenede Stater, 93463
    - Ridley-Tree Cancer Center-Solvang
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Sylmar, California, Forenede Stater, 91342
    - Olive View-University of California Los Angeles Medical Center
  - Torrance, California, Forenede Stater, 90509
    - Torrance Memorial Medical Center
  - Turlock, California, Forenede Stater, 95382
    - Emanuel Medical Center
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forenede Stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir Medical Center-Walnut Creek
  - Whittier, California, Forenede Stater, 90602
    - Presbyterian Intercommunity Hospital
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - Rocky Mountain Regional VA Medical Center
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forenede Stater, 80303
    - Boulder Community Foothills Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80222
    - Western States Cancer Research NCORP
  - Denver, Colorado, Forenede Stater, 80218
    - Saint Joseph Hospital - Cancer Centers of Colorado
  - Denver, Colorado, Forenede Stater, 80210
    - AdventHealth Porter
  - Edwards, Colorado, Forenede Stater, 81632
    - Shaw Cancer Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - Banner North Colorado Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forenede Stater, 80228
    - CommonSpirit Saint Anthony Hospital Cancer Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - Banner North Colorado Medical Center - Loveland Campus
  - Montrose, Colorado, Forenede Stater, 81401
    - Montrose Memorial Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forenede Stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forenede Stater, 80401
    - Intermountain Health Lutheran Hospital
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06610
    - Bridgeport Hospital
  - Bridgeport, Connecticut, Forenede Stater, 06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Danbury, Connecticut, Forenede Stater, 06810
    - Danbury Hospital
  - Farmington, Connecticut, Forenede Stater, 06030
    - University of Connecticut
  - Greenwich, Connecticut, Forenede Stater, 06830
    - Greenwich Hospital
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Manchester, Connecticut, Forenede Stater, 06040
    - Manchester Memorial Hospital
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - New Haven, Connecticut, Forenede Stater, 06511
    - Yale-New Haven Hospital Saint Raphael Campus
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, Forenede Stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Torrington, Connecticut, Forenede Stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Harold Leever Regional Cancer Center
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20037
    - George Washington University Medical Center
  - Washington D.C., District of Columbia, Forenede Stater, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington D.C., District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Boca Raton, Florida, Forenede Stater, 33486
    - Boca Raton Regional Hospital
  - Boca Raton, Florida, Forenede Stater, 33428
    - Lynn Regional Cancer Center - West
  - Boca Raton, Florida, Forenede Stater, 33486
    - Boca Raton Comprehensive Cancer Center
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Halifax Health Cancer Center for Hope - Daytona Beach
  - Deerfield Beach, Florida, Forenede Stater, 33064
    - Broward Health North
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Forenede Stater, 32610
    - UF Health Cancer Institute - Gainesville
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forenede Stater, 32207
    - Baptist MD Anderson Cancer Center
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Jacksonville, Florida, Forenede Stater, 32204
    - Saint Vincent's Medical Center
  - Jupiter, Florida, Forenede Stater, 33458
    - Jupiter Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Lakeland, Florida, Forenede Stater, 33805
    - The Watson Clinic
  - Leesburg, Florida, Forenede Stater, 34788
    - Cancer Centers of Central Florida PA
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Forenede Stater, 33176
    - Miami Cancer Institute
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orange Park, Florida, Forenede Stater, 32073
    - 21st Century Oncology-Orange Park
  - Orlando, Florida, Forenede Stater, 32806
    - Orlando Health Cancer Institute
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
  - Pensacola, Florida, Forenede Stater, 32504
    - Sacred Heart Hospital
  - Sarasota, Florida, Forenede Stater, 34239
    - Florida Cancer Specialists - Sarasota Downtown
  - Stuart, Florida, Forenede Stater, 34994
    - Martin Medical Center
  - Stuart, Florida, Forenede Stater, 34994
    - Robert and Carol Weissman Cancer Center at Martin Health
  - Stuart, Florida, Forenede Stater, 34997
    - Martin Hospital South
  - Titusville, Florida, Forenede Stater, 32796
    - Space Coast Cancer Centers-Titusville
  - Weston, Florida, Forenede Stater, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30303
    - Grady Health System
  - Atlanta, Georgia, Forenede Stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Atlanta Regional CCOP
  - Augusta, Georgia, Forenede Stater, 30912
    - Augusta University Medical Center
  - Augusta, Georgia, Forenede Stater, 30901
    - Augusta Oncology Associates PC-D'Antignac
  - Austell, Georgia, Forenede Stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forenede Stater, 30033
    - Emory Decatur Hospital
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - Northside Hospital - Gwinnett
  - Macon, Georgia, Forenede Stater, 31201
    - Atrium Health Navicent
  - Marietta, Georgia, Forenede Stater, 30060
    - Wellstar Kennestone Hospital
  - Riverdale, Georgia, Forenede Stater, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
  - Valdosta, Georgia, Forenede Stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96859
    - Tripler Army Medical Center
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Forenede Stater, 96793
    - Pacific Cancer Institute of Maui
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Pocatello, Idaho, Forenede Stater, 83201
    - Portneuf Medical Center
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - OSF Saint Anthony's Health Center
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Northwest Community Hospital
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush-Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forenede Stater, 61701
    - OSF Saint Joseph Medical Center
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital Association
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60657
    - UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forenede Stater, 60631
    - Presence Resurrection Medical Center
  - Chicago, Illinois, Forenede Stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, Forenede Stater, 60616
    - Mercy Hospital and Medical Center
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush MD Anderson Cancer Center
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Heartland Cancer Research NCORP
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Elmhurst, Illinois, Forenede Stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Galesburg, Illinois, Forenede Stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Cottage
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Geneva, Illinois, Forenede Stater, 60134
    - LaGrange Oncology Associates
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Illinois CancerCare-Havana
  - Hinsdale, Illinois, Forenede Stater, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Hopedale, Illinois, Forenede Stater, 61747
    - Hopedale Medical Complex - Hospital
  - Joliet, Illinois, Forenede Stater, 60435
    - Duly Health and Care Joliet
  - Joliet, Illinois, Forenede Stater, 60432
    - Midwest Center for Hematology Oncology
  - Kankakee, Illinois, Forenede Stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Kewanee, Illinois, Forenede Stater, 61443
    - Kewanee Hospital
  - La Grange, Illinois, Forenede Stater, 60525
    - AMITA Health Adventist Medical Center
  - Libertyville, Illinois, Forenede Stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Porubcin, Michael MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Sharis, Christine M MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Stoffel, Thomas J MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Vigliotti, Antonio, P.G. M.D. (UIA Investigator)
  - Monmouth, Illinois, Forenede Stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forenede Stater, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - SSM Health Good Samaritan
  - Naperville, Illinois, Forenede Stater, 60540
    - Edward Hospital/Cancer Center
  - Niles, Illinois, Forenede Stater, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Forenede Stater, 61761
    - Carle Cancer Institute Normal
  - Normal, Illinois, Forenede Stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Normal, Illinois, Forenede Stater, 61761
    - Mid-Illinois Hematology Oncology Associates Limited
  - Normal, Illinois, Forenede Stater, 61761
    - Carle BroMenn Medical Center
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Olympia Fields, Illinois, Forenede Stater, 60461
    - Franciscan St. James Health-Olympia Fields Campus
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forenede Stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - Pekin Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forenede Stater, 61108
    - OSF Saint Anthony Medical Center
  - Rockford, Illinois, Forenede Stater, 61104
    - Swedish American Hospital
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Skokie, Illinois, Forenede Stater, 60076
    - Edward H Kaplan MD and Associates
  - Skokie, Illinois, Forenede Stater, 60077
    - Midwest Cancer Research Group Incorporated
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Saint Margaret's Hospital
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forenede Stater, 62781
    - Springfield Memorial Hospital
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Winfield, Illinois, Forenede Stater, 60190
    - Northwestern Medicine Central DuPage Hospital
- Indiana
  - Anderson, Indiana, Forenede Stater, 46016
    - Ascension Saint Vincent Anderson
  - Beech Grove, Indiana, Forenede Stater, 46107
    - Franciscan Saint Francis Health-Beech Grove
  - Bloomington, Indiana, Forenede Stater, 47408
    - IU Health Bloomington
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Goshen, Indiana, Forenede Stater, 46526
    - Goshen Center for Cancer Care
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46219
    - Community Cancer Center East
  - Indianapolis, Indiana, Forenede Stater, 46256
    - Community Cancer Center North
  - Indianapolis, Indiana, Forenede Stater, 46260
    - Ascension Saint Vincent Indianapolis Hospital
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forenede Stater, 46350
    - IU Health La Porte Hospital
  - Lafayette, Indiana, Forenede Stater, 47904
    - IU Health Arnett Cancer Care
  - Lafayette, Indiana, Forenede Stater, 47905
    - Horizon Oncology Research LLC
  - Merrillville, Indiana, Forenede Stater, 46410
    - Premier Oncology Hematology Associates
  - Michigan City, Indiana, Forenede Stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Muncie, Indiana, Forenede Stater, 47303
    - IU Health Ball Memorial Hospital
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - South Bend Clinic
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Saint Luke's Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forenede Stater, 50325
    - UI Health Care Mission Cancer and Blood - West Des Moines Clinic
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Heartland Oncology and Hematology LLP
  - Davenport, Iowa, Forenede Stater, 52804
    - MercyOne Genesis Davenport Cancer Center
  - Davenport, Iowa, Forenede Stater, 52803
    - MercyOne Genesis Davenport Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forenede Stater, 50307
    - Mercy Capitol
  - Des Moines, Iowa, Forenede Stater, 50309
    - UI Health Care Mission Cancer and Blood - Des Moines Clinic
  - Des Moines, Iowa, Forenede Stater, 50314
    - UI Health Care Mission Cancer and Blood - Laurel Clinic
  - Dubuque, Iowa, Forenede Stater, 52001
    - Finley Hospital
  - Dubuque, Iowa, Forenede Stater, 52001
    - Medical Associates Clinic PC
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forenede Stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forenede Stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forenede Stater, 51104
    - Saint Luke's Regional Medical Center
  - Waterloo, Iowa, Forenede Stater, 50701
    - Cedar Valley Medical Specialists
  - Waterloo, Iowa, Forenede Stater, 50702
    - MercyOne Waterloo Cancer Center
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Liberal, Kansas, Forenede Stater, 67901
    - Southwest Medical Center
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Cancer Center
  - Olathe, Kansas, Forenede Stater, 66061
    - The University of Kansas Cancer Center - Olathe
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Overland Park, Kansas, Forenede Stater, 66210
    - Radiation Oncology Practice Corporation Southwest
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Prairie Village, Kansas, Forenede Stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forenede Stater, 66204
    - AdventHealth Shawnee Mission
  - Topeka, Kansas, Forenede Stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - King's Daughter's Medical Center
  - Ashland, Kentucky, Forenede Stater, 41101
    - Our Lady Bellefonte Hospital
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forenede Stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Owensboro, Kentucky, Forenede Stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71301
    - Christus Saint Frances Cabrini Hospital
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Baton Rouge General Medical Center
  - Covington, Louisiana, Forenede Stater, 70433
    - Ochsner Health Center-Covington
  - Metairie, Louisiana, Forenede Stater, 70006
    - Metairie Oncologists
  - Monroe, Louisiana, Forenede Stater, 71202
    - Ochsner LSU Health Monroe Medical Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Forenede Stater, 71103
    - LSU Health Sciences Center at Shreveport
  - Shreveport, Louisiana, Forenede Stater, 71105
    - Highland Clinic
  - Shreveport, Louisiana, Forenede Stater, 71105
    - CHRISTUS Highland Medical Center
  - Shreveport, Louisiana, Forenede Stater, 71101
    - Overton Brooks Veteran's Administration Medical Center
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Lewiston, Maine, Forenede Stater, 04240
    - Central Maine Medical Center
  - Lewiston, Maine, Forenede Stater, 04240
    - Saint Mary's Regional Medical Center
  - Portland, Maine, Forenede Stater, 04101
    - Mercy Hospital
  - Scarborough, Maine, Forenede Stater, 04074
    - MaineHealth Maine Medical Center- Scarborough
  - Waterville, Maine, Forenede Stater, 04901
    - Maine General Medical Center-Thayer
  - Westbrook, Maine, Forenede Stater, 04092
    - New England Cancer Specialists
  - York Village, Maine, Forenede Stater, 03909
    - York Hospital
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - Luminis Health Anne Arundel Medical Center
  - Baltimore, Maryland, Forenede Stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21202
    - Mercy Medical Center
  - Baltimore, Maryland, Forenede Stater, 21218
    - MedStar Union Memorial Hospital
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Forenede Stater, 21239
    - MedStar Good Samaritan Hospital
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Bethesda, Maryland, Forenede Stater, 20814
    - Suburban Hospital
  - Cumberland, Maryland, Forenede Stater, 21502
    - UPMC Western Maryland
  - Easton, Maryland, Forenede Stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Elkton, Maryland, Forenede Stater, 21921
    - Christiana Care - Union Hospital
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
  - Kensington, Maryland, Forenede Stater, 20895
    - Associates in Oncology Hematology PC -Kensington
  - Rockville, Maryland, Forenede Stater, 20850
    - Maryland Oncology Hematology PA-Aquilino Cancer Center
  - Salisbury, Maryland, Forenede Stater, 21801
    - TidalHealth Peninsula Regional
  - Silver Spring, Maryland, Forenede Stater, 20910
    - Holy Cross Hospital
  - Towson, Maryland, Forenede Stater, 21204
    - UM Saint Joseph Medical Center
- Massachusetts
  - Attleboro, Massachusetts, Forenede Stater, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forenede Stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Brighton, Massachusetts, Forenede Stater, 02135
    - Dana-Farber Cancer Institute at Boston Medical Center - Brighton
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Clinic
  - Concord, Massachusetts, Forenede Stater, 01742
    - Commonwealth Hematology Oncology PC-Concord
  - Danvers, Massachusetts, Forenede Stater, 01923
    - Mass General/North Shore Cancer Center
  - Dorchester, Massachusetts, Forenede Stater, 02124
    - Dana Farber Community Cancer Care-Dorchester
  - Fall River, Massachusetts, Forenede Stater, 02721
    - Saint Anne's Hospital
  - Fitchburg, Massachusetts, Forenede Stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Framingham, Massachusetts, Forenede Stater, 01702
    - MetroWest Medical Center-Framingham Union Hospital
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Haverhill, Massachusetts, Forenede Stater, 01830
    - Dana Farber Community Cancer Care-Haverhill
  - Hyannis, Massachusetts, Forenede Stater, 02601
    - Cape Cod Hospital
  - Leominster, Massachusetts, Forenede Stater, 01453
    - HealthAlliance Hospital - Leominster
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
  - Lowell, Massachusetts, Forenede Stater, 01852
    - Saints Memorial Medical Center
  - Methuen, Massachusetts, Forenede Stater, 01844
    - Holy Family Hospital
  - Methuen, Massachusetts, Forenede Stater, 01844
    - Dana Farber-Merrimack Valley
  - Norwood, Massachusetts, Forenede Stater, 02062
    - Norwood Hospital
  - Pittsfield, Massachusetts, Forenede Stater, 01201
    - Berkshire Medical Center - Cancer Center
  - Quincy, Massachusetts, Forenede Stater, 02169
    - Dana Farber Community Cancer Care-Quincy
  - South Weymouth, Massachusetts, Forenede Stater, 02190
    - South Shore Hospital
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Stoneham, Massachusetts, Forenede Stater, 02180
    - Dana Farber Community Cancer Care-Stoneham
  - Taunton, Massachusetts, Forenede Stater, 02780
    - Morton Hospital and Medical Center
  - Weymouth, Massachusetts, Forenede Stater, 02189
    - Dana Farber Community Cancer Care-Weymouth
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center - University Campus
  - Worcester, Massachusetts, Forenede Stater, 01606
    - Reliant Medical Group Inc
  - Worcester, Massachusetts, Forenede Stater, 01605
    - Commonwealth Hematology Oncology PC-Worcester
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Rogel Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Trinity Health Saint Joseph Mercy Hospital Ann Arbor
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forenede Stater, 48706
    - McLaren Cancer Institute-Bay City
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Dearborn, Michigan, Forenede Stater, 48124
    - Corewell Health Dearborn Hospital
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Henry Ford Health Saint John Hospital
  - East Lansing, Michigan, Forenede Stater, 48823
    - Michigan State University
  - Escanaba, Michigan, Forenede Stater, 49829
    - OSF Saint Francis Hospital and Medical Group
  - Flint, Michigan, Forenede Stater, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Forenede Stater, 48532
    - McLaren Cancer Institute-Flint
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Corewell Health Grand Rapids Hospitals - Butterworth Hospital
  - Holland, Michigan, Forenede Stater, 49423
    - Holland Community Hospital
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Beacon Kalamazoo
  - Lansing, Michigan, Forenede Stater, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Forenede Stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Forenede Stater, 48446
    - Lapeer Regional Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Marquette, Michigan, Forenede Stater, 49855
    - UP Health System Marquette
  - Midland, Michigan, Forenede Stater, 48670
    - MyMichigan Medical Center Midland
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Mount Clemens, Michigan, Forenede Stater, 48043
    - McLaren Cancer Institute-Macomb
  - Muskegon, Michigan, Forenede Stater, 49442
    - Mercy Health Partners-Hackley Campus
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Petoskey, Michigan, Forenede Stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forenede Stater, 48341
    - Trinity Health Saint Joseph Mercy Oakland Hospital
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Rochester, Michigan, Forenede Stater, 48307
    - Crittenton Hospital
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Corewell Health William Beaumont University Hospital
  - Saginaw, Michigan, Forenede Stater, 48601
    - MyMichigan Medical Center Saginaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Oncology Care Associates PLLC
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Saint Joseph Hospital
  - Southfield, Michigan, Forenede Stater, 48075
    - Henry Ford Health Providence Southfield Hospital
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - Henry Ford Health Warren Hospital
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
- Minnesota
  - Alexandria, Minnesota, Forenede Stater, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Etzell, Paul S MD (UIA Investigator)
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Swenson, Wade II, MD (UIA Investigator)
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forenede Stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forenede Stater, 55355
    - Meeker County Memorial Hospital
  - Mankato, Minnesota, Forenede Stater, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55455
    - University of Minnesota/Masonic Cancer Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Virginia Piper Cancer Institute
  - Montevideo, Minnesota, Forenede Stater, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - Saint Joseph's Hospital - Healtheast
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Fairview Cancer Center - Woodbury
- Mississippi
  - Hattiesburg, Mississippi, Forenede Stater, 39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Hattiesburg, Mississippi, Forenede Stater, 39402
    - Hematology and Oncology Clinic
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - Jackson, Mississippi, Forenede Stater, 39202
    - Jackson Oncology Associates PLLC
  - Keesler Air Force Base, Mississippi, Forenede Stater, 39534
    - Keesler Medical Center
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63701
    - Southeast Missouri Hospital
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forenede Stater, 65201
    - Missouri Cancer Associates
  - Columbia, Missouri, Forenede Stater, 65201
    - Veterans Administration
  - Columbia, Missouri, Forenede Stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forenede Stater, 65101
    - Capital Region Medical Center
  - Jefferson City, Missouri, Forenede Stater, 65109
    - MU Health Care Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forenede Stater, 64114
    - Saint Joseph Health Center
  - Kansas City, Missouri, Forenede Stater, 64114
    - Radiation Oncology Practice Corporation South
  - Kansas City, Missouri, Forenede Stater, 64154
    - Radiation Oncology Practice Corporation - North
  - Kansas City, Missouri, Forenede Stater, 64108
    - University Health Truman Medical Center
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Hospital
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Springfield, Missouri, Forenede Stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forenede Stater, 63104
    - SSM Health Saint Louis University Hospital
  - St Louis, Missouri, Forenede Stater, 63109
    - Mercy Infusion Center - Chippewa
  - St Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forenede Stater, 63141
    - Saint Louis-Cape Girardeau CCOP
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - St Louis, Missouri, Forenede Stater, 63141
    - Center for Cancer Care and Research
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Forenede Stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Billings, Montana, Forenede Stater, 59107
    - Deaconess Medical Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Health Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Sletten Cancer Institute
  - Havre, Montana, Forenede Stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Medical Oncology
  - Kalispell, Montana, Forenede Stater, 59901
    - Logan Health Medical Center
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Forenede Stater, 59802
    - Montana Cancer Specialists
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Center
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - Nebraska Cancer Specialists/Oncology Hematology West PC
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Cancer Research Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68106
    - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forenede Stater, 68106
    - Cancer Alliance of Nebraska
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson-Tahoe Specialty Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89120
    - Nevada Cancer Research Foundation NCORP
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Exeter, New Hampshire, Forenede Stater, 03833
    - Exeter Hospital
  - Keene, New Hampshire, Forenede Stater, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Laconia, New Hampshire, Forenede Stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Solinsky Center for Cancer Care
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Elliot Hospital
  - Nashua, New Hampshire, Forenede Stater, 03060
    - Saint Joseph Hospital
  - Nashua, New Hampshire, Forenede Stater, 03060
    - Foundation Medical Partners
  - Portsmouth, New Hampshire, Forenede Stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Brick, New Jersey, Forenede Stater, 08724
    - Ocean University Medical Center
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - Edison, New Jersey, Forenede Stater, 08818
    - John F Kennedy Medical Center
  - Englewood, New Jersey, Forenede Stater, 07631
    - Englewood Hospital and Medical Center
  - Flemington, New Jersey, Forenede Stater, 08822
    - Hunterdon Medical Center
  - Freehold, New Jersey, Forenede Stater, 07728
    - CentraState Medical Center
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Livingston, New Jersey, Forenede Stater, 07039
    - Cooperman Barnabas Medical Center
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Montclair, New Jersey, Forenede Stater, 07042
    - Mountainside Hospital
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forenede Stater, 08060
    - Virtua Memorial
  - Neptune City, New Jersey, Forenede Stater, 07753
    - Jersey Shore Medical Center
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - New Brunswick, New Jersey, Forenede Stater, 08901
    - Saint Peter's University Hospital
  - Newark, New Jersey, Forenede Stater, 07101
    - Rutgers New Jersey Medical School
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Newark, New Jersey, Forenede Stater, 07102
    - Saint Michael's Medical Center
  - Paterson, New Jersey, Forenede Stater, 07503
    - Saint Joseph's Regional Medical Center
  - Pennington, New Jersey, Forenede Stater, 08534
    - Capital Health Medical Center-Hopewell
  - Phillipsburg, New Jersey, Forenede Stater, 08865
    - Saint Luke's Hospital-Warren Campus
  - Plainsboro, New Jersey, Forenede Stater, 08536
    - Penn Medicine Princeton Health
  - Pomona, New Jersey, Forenede Stater, 08240
    - AtlantiCare Regional Medical Center -Main Campus
  - Red Bank, New Jersey, Forenede Stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Health System Ridgewood Campus
  - Somers Point, New Jersey, Forenede Stater, 08244
    - Shore Memorial Hospital
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Sparta, New Jersey, Forenede Stater, 07871
    - Sparta Cancer Treatment Center
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
  - Vineland, New Jersey, Forenede Stater, 08360
    - Inspira Medical Center Vineland
  - Voorhees Township, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center-Downtown
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Hematology Oncology Associates
  - Albuquerque, New Mexico, Forenede Stater, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center-Las Cruces
  - San Juan, New Mexico, Forenede Stater, 87401
    - San Juan Regional Medical Center
  - Santa Fe, New Mexico, Forenede Stater, 87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Albany, New York, Forenede Stater, 12206
    - New York Oncology Hematology PC - Albany
  - Albany, New York, Forenede Stater, 12208
    - New York Oncology Hematology PC - Albany Medical Center
  - Amsterdam, New York, Forenede Stater, 12010
    - New York Oncology Hematology PC - Amsterdam
  - Brooklyn, New York, Forenede Stater, 11235
    - Coney Island Hospital
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Clifton Park, New York, Forenede Stater, 12065
    - New York Oncology Hematology PC - Clifton Park
  - Clifton Springs, New York, Forenede Stater, 14432
    - Finger Lakes Hematology and Oncology
  - Cooperstown, New York, Forenede Stater, 13326
    - Mary Imogene Bassett Hospital
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Glens Falls, New York, Forenede Stater, 12801
    - Adirondack Cancer Center
  - Harris, New York, Forenede Stater, 12742
    - Catskill Regional Medical Center
  - Hudson, New York, Forenede Stater, 12534
    - New York Oncology Hematology PC-Hudson
  - Jamaica, New York, Forenede Stater, 11432
    - Queens Hospital Center
  - Kingston, New York, Forenede Stater, 12401
    - Benedictine Hospital
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health NCORP
  - Lake Success, New York, Forenede Stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset, New York, Forenede Stater, 11030
    - North Shore University Hospital
  - Middletown, New York, Forenede Stater, 10940
    - Garnet Health Medical Center
  - Mineola, New York, Forenede Stater, 11501
    - NYU Langone Hospital - Long Island
  - New Hyde Park, New York, Forenede Stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forenede Stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forenede Stater, 10035
    - Ralph Lauren Center for Cancer Care and Prevention
  - New York, New York, Forenede Stater, 10003
    - Mount Sinai Union Square
  - Nyack, New York, Forenede Stater, 10960
    - Nyack Hospital
  - Plattsburgh, New York, Forenede Stater, 12901
    - Champlain Valley Physicians Hospital Medical Center
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Vassar Brothers Medical Center
  - Poughkeepsie, New York, Forenede Stater, 12601
    - MidHudson Regional Hospital of Westchester Medical Center
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Hudson Valley Hematology Oncology Associates
  - Poughkeepsie, New York, Forenede Stater, 12601
    - The Dyson Center for Cancer Care
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rochester, New York, Forenede Stater, 14620
    - Highland Hospital
  - Rochester, New York, Forenede Stater, 14623
    - Interlakes Foundation Inc-Rochester
  - Rochester, New York, Forenede Stater, 14621
    - Rochester General Hospital
  - Staten Island, New York, Forenede Stater, 10305
    - Staten Island University Hospital
  - Staten Island, New York, Forenede Stater, 10310
    - Richmond University Medical Center
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - The Bronx, New York, Forenede Stater, 10466
    - Montefiore Medical Center-Wakefield Campus
  - The Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Forenede Stater, 10451
    - Lincoln Medical and Mental Health Center
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - The Bronx, New York, Forenede Stater, 10456
    - Bronx-Lebanon Hospital Center
  - Troy, New York, Forenede Stater, 12180
    - New York Oncology Hematology PC - Troy
  - Utica, New York, Forenede Stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospital
  - Asheville, North Carolina, Forenede Stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Cary, North Carolina, Forenede Stater, 27518
    - Waverly Hematology Oncology
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Eden, North Carolina, Forenede Stater, 27288
    - Moorehead Memorial Hospital
  - Fayetteville, North Carolina, Forenede Stater, 28304
    - Cape Fear Valley Health System
  - Gastonia, North Carolina, Forenede Stater, 28054
    - CaroMont Regional Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Radiation Oncology
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Greenville, North Carolina, Forenede Stater, 27834
    - East Carolina University
  - Henderson, North Carolina, Forenede Stater, 27536
    - Maria Parham Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - AdventHealth Hendersonville
  - High Point, North Carolina, Forenede Stater, 27262
    - High Point Regional Hospital
  - Kinston, North Carolina, Forenede Stater, 28501
    - ECU Health Oncology Kinston
  - Lumberton, North Carolina, Forenede Stater, 28358
    - Southeastern Regional Medical Center
  - Oxford, North Carolina, Forenede Stater, 27565
    - Granville Medical Center
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27609
    - Duke Cancer Center Raleigh
  - Raleigh, North Carolina, Forenede Stater, 27607
    - UNC Health Cancer Care Raleigh
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Roxboro, North Carolina, Forenede Stater, 27573
    - Person Memorial Hospital
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, Forenede Stater, 28677
    - Iredell Memorial Hospital
  - Washington, North Carolina, Forenede Stater, 27889
    - Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
  - Wilmington, North Carolina, Forenede Stater, 28401
    - Novant Health New Hanover Regional Medical Center
  - Wilson, North Carolina, Forenede Stater, 27893
    - Wilson Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forenede Stater, 27104
    - Southeast Clinical Oncology Research Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Saint Alexius Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Health System - Akron Campus
  - Barberton, Ohio, Forenede Stater, 44203
    - Summa Health System - Barberton Campus
  - Bellefontaine, Ohio, Forenede Stater, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Bryan, Ohio, Forenede Stater, 43506
    - Community Hospital and Wellness Centers
  - Canton, Ohio, Forenede Stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Clyde, Ohio, Forenede Stater, 43410
    - North Coast Cancer Care-Clyde
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forenede Stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45459
    - Dayton NCI Community Oncology Research Program
  - Dayton, Ohio, Forenede Stater, 45428
    - Dayton Veterans Affairs Medical Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center Incorporated
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Fremont, Ohio, Forenede Stater, 43420
    - Fremont Memorial Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kenton, Ohio, Forenede Stater, 43326
    - Cole, Sharon, K. M.D. (UIA Investigator)
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Maumee, Ohio, Forenede Stater, 43537
    - Saint Luke's Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Norwalk, Ohio, Forenede Stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forenede Stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Salem, Ohio, Forenede Stater, 44460
    - UH Seidman Cancer Center at Salem Regional Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forenede Stater, 44870
    - Firelands Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Medical Center
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forenede Stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forenede Stater, 43623
    - Stark, Michael, Edward. M.D. (UIA Investigator)
  - Toledo, Ohio, Forenede Stater, 43608
    - Mercy Health - Saint Vincent Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Warren, Ohio, Forenede Stater, 44484
    - Saint Joseph Warren Hospital
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Wilmington, Ohio, Forenede Stater, 45177
    - Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wooster, Ohio, Forenede Stater, 44691
    - Cancer Treatment Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
    - Wright-Patterson Medical Center
  - Xenia, Ohio, Forenede Stater, 45385
    - Greene Memorial Hospital
  - Youngstown, Ohio, Forenede Stater, 44501
    - Tod Children's Hospital - Forum Health
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Cancer Care Associates
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - Saint John Medical Center
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Saint Francis Children's Hospital
- Oregon
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Bend, Oregon, Forenede Stater, 97701
    - Bend Memorial Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Grants Pass, Oregon, Forenede Stater, 97527
    - Three Rivers Community Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Klamath Falls, Oregon, Forenede Stater, 97601
    - Sky Lakes Medical Center - Cancer Treatment Center
  - Medford, Oregon, Forenede Stater, 97504
    - Asante Health System
  - Medford, Oregon, Forenede Stater, 97504
    - Providence Medford Medical Center
  - Medford, Oregon, Forenede Stater, 97504
    - Asante Rogue Regional Medical Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Portland, Oregon, Forenede Stater, 97227
    - Legacy Emanuel Hospital and Health Center
  - Portland, Oregon, Forenede Stater, 97216
    - Adventist Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Compass Oncology Rose Quarter
  - Salem, Oregon, Forenede Stater, 97301
    - Salem Hospital
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Allentown, Pennsylvania, Forenede Stater, 18102
    - Sacred Heart Hospital
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Darby, Pennsylvania, Forenede Stater, 19023-1291
    - Mercy Fitzgerald Hospital
  - Doylestown, Pennsylvania, Forenede Stater, 18901
    - Doylestown Hospital
  - Drexel Hill, Pennsylvania, Forenede Stater, 19026
    - Delaware County Memorial Hospital
  - DuBois, Pennsylvania, Forenede Stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Easton, Pennsylvania, Forenede Stater, 18042
    - Easton Hospital
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Erie, Pennsylvania, Forenede Stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Erie, Pennsylvania, Forenede Stater, 16544
    - Saint Vincent Hospital
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Johnstown, Pennsylvania, Forenede Stater, 15905-4398
    - Conemaugh Memorial Medical Center
  - Lancaster, Pennsylvania, Forenede Stater, 17602
    - Lancaster General Hospital
  - Langhorne, Pennsylvania, Forenede Stater, 19047
    - Saint Mary Medical and Regional Cancer Center
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - Meadowbrook, Pennsylvania, Forenede Stater, 19046
    - Redeemer Health
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19141
    - Einstein Medical Center Philadelphia
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Pennsylvania Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19102
    - Drexel University School of Medicine
  - Philadelphia, Pennsylvania, Forenede Stater, 19118
    - Temple Health - Chestnut Hill Hospital
  - Phoenixville, Pennsylvania, Forenede Stater, 19460
    - Reading Hospital McGlinn Cancer Institute at Phoenixville
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - UPMC Hillman Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Hospital
  - Reading, Pennsylvania, Forenede Stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Scranton Hematology Oncology
  - Scranton, Pennsylvania, Forenede Stater, 18501
    - Mercy Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Sellersville, Pennsylvania, Forenede Stater, 18960
    - Grand View Hospital
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Forenede Stater, 16803
    - Mount Nittany Medical Center
  - Upland, Pennsylvania, Forenede Stater, 19013
    - Associates In Hematology Oncology PC-Upland
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, Forenede Stater, 19390
    - Jennersville Regional Hospital
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Main Line Health NCORP
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Cranston, Rhode Island, Forenede Stater, 02920
    - Hematology and Oncology Associates of Rhode Island Inc
  - Pawtucket, Rhode Island, Forenede Stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital
  - Providence, Rhode Island, Forenede Stater, 02906
    - Miriam Hospital
  - Providence, Rhode Island, Forenede Stater, 02908
    - Roger Williams Medical Center
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Hospital
  - Beaufort, South Carolina, Forenede Stater, 29902
    - Beaufort Memorial Hospital
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital
  - Columbia, South Carolina, Forenede Stater, 29210
    - South Carolina Oncology Associates PA
  - Florence, South Carolina, Forenede Stater, 29506
    - McLeod Regional Medical Center
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5045
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Bristol, Tennessee, Forenede Stater, 37620
    - Wellmont Medical Associates Oncology and Hematology-Bristol
  - Chattanooga, Tennessee, Forenede Stater, 37403
    - Erlanger Medical Center
  - Cookeville, Tennessee, Forenede Stater, 38501
    - Cookeville Regional Medical Center
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Germantown, Tennessee, Forenede Stater, 38138
    - Jones Clinic
  - Jackson, Tennessee, Forenede Stater, 38301
    - Jackson-Madison County General Hospital
  - Jackson, Tennessee, Forenede Stater, 38301
    - The Jackson Clinic PA
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37920
    - University of Tennessee - Knoxville
  - Knoxville, Tennessee, Forenede Stater, 37909
    - Tennessee Cancer Specialists-Dowell Springs
  - Knoxville, Tennessee, Forenede Stater, 37920
    - East Tennessee Baptist Hospital-Mercy Health Partners
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Covenant Health Cancer Centers
  - Memphis, Tennessee, Forenede Stater, 38163
    - University of Tennessee Health Science Center
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Nashville, Tennessee, Forenede Stater, 37208
    - Meharry Medical College
  - Nashville, Tennessee, Forenede Stater, 37203
    - Nashville Oncology Associates PC
  - Nashville, Tennessee, Forenede Stater, 37205
    - Saint Thomas Hospital
  - Nashville, Tennessee, Forenede Stater, 37203
    - Nashville Breast Center
  - Nashville, Tennessee, Forenede Stater, 37236
    - Saint Thomas Midtown Hospital
  - Nashville, Tennessee, Forenede Stater, 37203
    - Tennessee Oncology Elliston Place Plaza
  - Powell, Tennessee, Forenede Stater, 37849
    - Saint Mary's North Cancer Center
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Austin, Texas, Forenede Stater, 78701
    - Dell Seton Medical Center at The University of Texas
  - Austin, Texas, Forenede Stater, 78705
    - Texas Oncology-Austin Midtown
  - Austin, Texas, Forenede Stater, 78731
    - Texas Oncology - Central Austin Cancer Center
  - Austin, Texas, Forenede Stater, 78745
    - Texas Oncology - South Austin Cancer Center
  - Austin, Texas, Forenede Stater, 78758
    - Texas Oncology-Austin North
  - Austin, Texas, Forenede Stater, 78759
    - Texas Oncology Seton Northwest
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Burleson, Texas, Forenede Stater, 76115
    - The Center for Cancer and Blood Disorders-Burleson
  - Cedar Park, Texas, Forenede Stater, 78613
    - Texas Oncology-Cedar Park
  - Cleburne, Texas, Forenede Stater, 76033
    - The Center for Cancer and Blood Disorders-Cleburne
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forenede Stater, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - Clements University Hospital
  - Duncanville, Texas, Forenede Stater, 75137
    - Dallas Oncology Consultants PA
  - El Paso, Texas, Forenede Stater, 79902
    - The Center for Integrative Cancer Medicine
  - Fort Sam Houston, Texas, Forenede Stater, 78234
    - Brooke Army Medical Center
  - Fort Worth, Texas, Forenede Stater, 76104
    - The Center for Cancer and Blood Disorders-Fort Worth
  - Houston, Texas, Forenede Stater, 77030
    - UT MD Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Lackland Air Force Base, Texas, Forenede Stater, 78236
    - Wilford Hall Medical Center
  - Laredo, Texas, Forenede Stater, 78041
    - Doctor's Hospital of Laredo
  - Lubbock, Texas, Forenede Stater, 79410
    - Covenant Medical Center-Lakeside
  - Lubbock, Texas, Forenede Stater, 79430
    - Texas Tech University Health Sciences Center-Lubbock
  - Mineral Wells, Texas, Forenede Stater, 76067
    - The Center for Cancer and Blood Disorders-Mineral Wells
  - Round Rock, Texas, Forenede Stater, 78665
    - Texas Oncology-Seton Williamson
  - Round Rock, Texas, Forenede Stater, 78681
    - Texas Oncology - Round Rock Cancer Center
  - San Antonio, Texas, Forenede Stater, 78229
    - University Hospital
  - San Antonio, Texas, Forenede Stater, 78229
    - University of Texas Health Science Center at San Antonio
  - San Marcos, Texas, Forenede Stater, 78666
    - Texas Oncology- San Marcos
  - Temple, Texas, Forenede Stater, 76508
    - Scott and White Memorial Hospital
  - Weatherford, Texas, Forenede Stater, 76086
    - The Center for Cancer and Blood Disorders-Weatherford
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Murray, Utah, Forenede Stater, 84107
    - Cottonwood Hospital Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forenede Stater, 84103
    - Intermountain Health Care
  - St. George, Utah, Forenede Stater, 84770
    - Saint George Regional Medical Center
- Vermont
  - Bennington, Vermont, Forenede Stater, 05201
    - Southwestern Vermont Medical Center
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont and State Agricultural College
  - Rutland, Vermont, Forenede Stater, 05701
    - Rutland Regional Medical Center
  - Windsor, Vermont, Forenede Stater, 05089
    - Mount Ascutney Hospital and Health Center
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Charlottesville, Virginia, Forenede Stater, 22911
    - Sentara Martha Jefferson Hospital
  - Danville, Virginia, Forenede Stater, 24541
    - Danville Regional Medical Center
  - Falls Church, Virginia, Forenede Stater, 22042
    - INOVA Fairfax Hospital
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology Inc
  - Gloucester, Virginia, Forenede Stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Hampton, Virginia, Forenede Stater, 23666
    - Virginia Oncology Associates-Hampton
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Alan B Pearson Regional Cancer Center
  - Newport News, Virginia, Forenede Stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Newport News, Virginia, Forenede Stater, 23606
    - Sentara Port Warwick
  - Norfolk, Virginia, Forenede Stater, 23507
    - Eastern Virginia Medical School
  - Norton, Virginia, Forenede Stater, 24273
    - Ballad Health Cancer Care - Norton
  - Richmond, Virginia, Forenede Stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23298
    - VCU Massey Comprehensive Cancer Center
  - Williamsburg, Virginia, Forenede Stater, 23185
    - Peninsula Cancer Institute-Williamsburg
- Washington
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Forenede Stater, 98033
    - EvergreenHealth Medical Center
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Olympia, Washington, Forenede Stater, 98507
    - Capital Medical Center
  - Port Angeles, Washington, Forenede Stater, 98362
    - Olympic Medical Center
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Medical Center-First Hill
  - Silverdale, Washington, Forenede Stater, 98383
    - Saint Joseph Medical Center Hematology and Oncology - Silverdale
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Sacred Heart Medical Center and Children's Hospital
  - Spokane, Washington, Forenede Stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99220
    - Rockwood Clinic
  - Spokane, Washington, Forenede Stater, 99208
    - Providence Holy Family Hospital
  - Tacoma, Washington, Forenede Stater, 98431
    - Madigan Army Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forenede Stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Compass Oncology Vancouver
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yakima, Washington, Forenede Stater, 98902
    - Cancer Institutes of Washington PLLC
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forenede Stater, 25702
    - Saint Mary's Medical Center
  - Huntington, West Virginia, Forenede Stater, 25701
    - Marshall University Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden Clark Medical Center
  - Princeton, West Virginia, Forenede Stater, 24740
    - Princeton Community Hospital
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Aspirus Cancer Care-Antigo-Volm Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54911
    - ThedaCare Regional Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54911
    - Fox Valley Surgical Associates Limited
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond du Lac, Wisconsin, Forenede Stater, 54935
    - Saint Agnes Hospital/Agnesian Cancer Center
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Aurora Cancer Care-Franklin
  - Glendale, Wisconsin, Forenede Stater, 53212
    - Aurora Cancer Care-Glendale
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forenede Stater, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - University of Wisconsin Carbone Cancer Center - Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Carbone Cancer Center - University Hospital
  - Madison, Wisconsin, Forenede Stater, 53715
    - SSM Health Dean Medical Group - South Madison Campus
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center
  - Mequon, Wisconsin, Forenede Stater, 53097
    - Ascension Columbia Saint Mary's Hospital-Ozaukee Campus-Mequon
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53210
    - Ascension Southeast Wisconsin Hospital-Saint Joseph-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Ascension Columbia Saint Mary's Hospital-Milwaukee Campus
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Medical Center - Minocqua
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53405
    - Ascension All Saints Hospital-Spring Street-Racine
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Aspirus Cancer Care - Stevens Point
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Cancer Care-Wausau
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Irland
- - Cork, Irland
    - Cork University Hospital
  - Dublin, Irland, 8
    - Saint James Hospital
  - Letterkenny, Irland, Co Donegal
    - Letterkenny General Hospital
- Co Cork
  - Cork, Co Cork, Irland
    - Bon Secours Hospital
  - Cork, Co Cork, Irland
    - South Infirmary Victoria Hospital
- Co Dublin
  - Dublin, Co Dublin, Irland, 24
    - Tallaght University Hospital
  - Dublin, Co Dublin, Irland, 4
    - Saint Vincent's University Hospital
  - Dublin, Co Dublin, Irland, 7
    - Mater Misericordiae University Hospital
  - Dublin, Co Dublin, Irland, 7
    - Mater Private Hospital
  - Dublin, Co Dublin, Irland, 9
    - Beaumont Hospital
  - Mount Merrion, Co Dublin, Irland, 4
    - Saint Vincent's Private Hospital
- Co Galway
  - Galway, Co Galway, Irland
    - University College Hospital Galway
- Co Limerick
  - Limerick, Co Limerick, Irland, 9
    - Mid-Western Regional Hospital
- Co Sligo
  - Sligo, Co Sligo, Irland
    - Sligo University Hospital
- Co Waterford
  - Waterford, Co Waterford, Irland, 9
    - University Hospital Waterford
New Zealand
- - Hamilton, New Zealand, 3204
    - Waikato Hospital
  - Wellington, New Zealand, 6021
    - Wellington Hospital
- Auckland
  - Grafton, Auckland, New Zealand, 1023
    - Auckland City Hospital
Peru
- - Lima, Peru, Lima 34
    - Instituto Nacional de Enfermedades Neoplasicas
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 75 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Patienter med operabelt histologisk bekræftet adenokarcinom i det kvindelige bryst, som har afsluttet primær kirurgisk behandling og opfylder følgende kriterier:
- ER og/eller progesteronreceptor (PR)-positiv: Østrogen- og/eller progesteronreceptorpositiv sygdom (som defineret af det lokale patologiske laboratorium)
- Negative aksillære noder: Som vurderet ved en sentinel lymfeknudebiopsi, en aksillær dissektion eller begge dele, og som defineret af den sjette udgave af American Joint Committee on Cancer (AJCC) iscenesættelseskriterier
- Tumorstørrelse 1,1-5,0 cm (eller 5 mm-1,0 cm plus ugunstige histologiske træk):
  - Ugunstige egenskaber defineret som middel eller dårlig nuklear og/eller histologisk kvalitet eller lymfovaskulær invasion
  - BEMÆRK: Definition af tumorstørrelse: Den tumorstørrelse, der anvendes til bestemmelse af egnethed, er den patologiske tumorstørrelse, som normalt bestemmes af tumorstørrelsen målt ved inspektion af bruttoprøven; hvis tumorstørrelsen måles mikroskopisk, og tumoren inkluderer duktalt karcinom in situ, bør målingen kun omfatte den invasive komponent af tumoren
- Tumoren skal være human epidermal vækstfaktor receptor 2 (Her2)/neu negativ ved enten fluorescerende in-situ hybridisering (FISH) eller immunhistokemi (f.eks. 0 eller 1+ af DAKO Herceptest)
Patienten og lægen skal være indforstået med at påbegynde standard kemoterapi og hormonbehandling som adjuverende terapi
En vævsprøve fra den primære brystkræft er blevet lokaliseret og er klar til at blive sendt til det relevante laboratorium efter samtykke er opnået og inden for 3 dage efter præregistrering. BEMÆRK: Til bestemmelse af oncotype-gentagelsesscore skal væv sendes til Genomic Health; hvis Oncotype DX Recurrence Score tidligere blev udført af Genomic Health (før præregistrering), skal væv indsendes til Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Central Biorepository and Pathology Facility ved randomisering
Leukocyttal >= 3500/mm^3
Blodplader >= 100.000/mm^3
Serumkreatinin =< 1,5 mg/dL
Serum aspartat transaminase (AST), der er =< 3 gange de øvre institutionelle grænser for normalen
Patienter skal være sygdomsfri for tidligere invasive maligniteter i >= 5 år med undtagelse af kurativt behandlet basalcelle- eller pladecellekarcinom i huden eller carcinom in situ i livmoderhalsen; patienter med tidligere ipsilateral eller kontralateral invasiv brystkræft eller med bilaterale synkrone kræftformer er ikke kvalificerede; patienter med tidligere ipsilateralt eller kontralateralt duktalt in situ karcinom (DCIS) er ikke kvalificerede
Forudgående behandling
- Obligatoriske forudgående operationskriterier:
  - Patienten skal forhåndsregistreres inden for 84 dage fra den sidste kirurgiske procedure, der kræves for at behandle den primære tumor tilstrækkeligt (bemærk venligst, at hvis marginalerne ikke er klare, og der skal udføres en resektion efter præregistrering, men før randomisering, vil patienten blive anset for at være inden for det 84-dages vindue, der er tilladt af protokollen og derfor kvalificeret)
  - Alle tumorer skal fjernes ved enten en mastektomi eller lokal excision plus en acceptabel aksillær procedure (dvs. sentinel lymfeknudebiopsi, aksillær dissektion eller begge dele); der skal være tilstrækkelige (mindst 1 mm, hvis marginbredden er specificeret) tumorfrie resektionsmargener (til invasivt og duktalt carcinom in-situ), for at patienterne er kvalificerede; patienter med lobulært karcinom in-situ, der involverer resektionsmarginerne, er berettigede
- Kriterier vedr.: andre tidligere behandlinger:
  - Ingen forudgående kemoterapi for denne malignitet
  - Ingen forudgående strålebehandling for denne malignitet; dette inkluderer ingen tidligere MammoSite Brachyterapi-strålebehandling (RT)
  - Hormonbehandling: Patienter, der udvikler brystkræft, mens de får en selektiv østrogenreceptormodulator (SERM; f.eks. tamoxifen, toremifen, raloxifen) eller en aromatasehæmmer (f.eks. anastrazol, letrozol, exemestan) til brystkræftforebyggelse eller en SERM-indikation. (f.eks. raloxifen mod osteoporose) er ikke kvalificerede; dog kan patienter have modtaget op til 8 uger med en SERM- eller aromatasehæmmer for denne malignitet og stadig være berettiget til undersøgelse
Patienter skal have en forventet levetid på mindst 10 år
Patienter med følgende medicinske tilstande bør ikke optages i undersøgelsen:
- Kronisk obstruktiv lungesygdom, der kræver behandling
- Kronisk leversygdom (fx skrumpelever, kronisk aktiv hepatitis)
- Tidligere historie med en cerebrovaskulær ulykke
- Anamnese med kongestiv hjertesvigt eller anden hjertesygdom, der ville repræsentere en kontraindikation for brugen af et antracyklin (f.eks. doxorubicin eller epirubicin)
- Kronisk psykiatrisk tilstand eller anden tilstand, der ville forringe overholdelse af behandlingsregimet
Kvinder må ikke være gravide eller ammende; alle kvinder i den fødedygtige alder skal have en blodprøve eller urinundersøgelse inden for 2 uger før forhåndsregistrering for at udelukke graviditet
- Kvinder i den fødedygtige alder skal kraftigt rådes til at bruge en accepteret og effektiv form for ikke-hormonel prævention (f. intrauterin enhed, kondomer, mellemgulv, abstinens)
Patienter må ikke tidligere have fået udført Oncotype DX-analysen, med undtagelse af patienter, der har fået foretaget analysen og har en recidivscore på 11-25

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Gruppe 1 (Oncotype DX-gentagelsesscore =< 10) Patienter i denne gruppe modtager hormonbehandling med tamoxifen, anastrozol, letrozol eller exemestan PO i op til 5 år. Nogle patienter fortsætter derefter med at modtage hormonbehandling i yderligere 5 år.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Letrozol Givet PO Andre navne: CGS 20267 Femara Fempro CGS-20267 CGS20267 Medicin: Anastrozol Givet PO Andre navne: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Medicin: Exemestan Givet PO Andre navne: Aromasin FCE-24304 Medicin: Tamoxifen Citrat Givet PO Andre navne: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide ICI 46474 ICI46474 Stråling: Stråleterapi Gennemgå strålebehandling eller delvis brystbestråling Andre navne: Kræftstrålebehandling ENERGY_TYPE Bestråle Bestrålet Bestråling Stråling Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, Stråling Energitype
Eksperimentel: Gruppe 2, Arm I (eksperimentel) Patienter modtager hormonbehandling som i gruppe 1 efter den behandlende læges skøn.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Letrozol Givet PO Andre navne: CGS 20267 Femara Fempro CGS-20267 CGS20267 Medicin: Anastrozol Givet PO Andre navne: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Medicin: Exemestan Givet PO Andre navne: Aromasin FCE-24304 Medicin: Tamoxifen Citrat Givet PO Andre navne: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide ICI 46474 ICI46474
Aktiv komparator: Gruppe 2, Arm II (standard) Patienter modtager standard kombinationskemoterapi efter den behandlende læges skøn. Inden for 4 uger efter den sidste dosis kemoterapi modtager patienterne hormonbehandling som i gruppe 1 efter den behandlende læges skøn.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Letrozol Givet PO Andre navne: CGS 20267 Femara Fempro CGS-20267 CGS20267 Medicin: Anastrozol Givet PO Andre navne: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Medicin: Exemestan Givet PO Andre navne: Aromasin FCE-24304 Medicin: Tamoxifen Citrat Givet PO Andre navne: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide ICI 46474 ICI46474 Stråling: Stråleterapi Gennemgå strålebehandling eller delvis brystbestråling Andre navne: Kræftstrålebehandling ENERGY_TYPE Bestråle Bestrålet Bestråling Stråling Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, Stråling Energitype
Eksperimentel: Gruppe 3 (Oncotype DX-gentagelsesscore >= 26) Patienter i denne gruppe får kombinationskemoterapi efterfulgt af hormonbehandling svarende til patienterne i gruppe to, der er udpeget til at modtage begge typer behandling.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Medicin: Letrozol Givet PO Andre navne: CGS 20267 Femara Fempro CGS-20267 CGS20267 Medicin: Anastrozol Givet PO Andre navne: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Medicin: Exemestan Givet PO Andre navne: Aromasin FCE-24304 Medicin: Tamoxifen Citrat Givet PO Andre navne: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide ICI 46474 ICI46474 Stråling: Stråleterapi Gennemgå strålebehandling eller delvis brystbestråling Andre navne: Kræftstrålebehandling ENERGY_TYPE Bestråle Bestrålet Bestråling Stråling Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, Stråling Energitype

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
5-års sygdomsfri overlevelse Tidsramme: Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, DFS-sats estimeret til 5 år	Sygdomsfri overlevelse (DFS) er defineret som tiden fra randomisering til første hændelse, hvor den første hændelse er en hvilken som helst af ipsilateral brysttumor-tilbagefald, lokalt recidiv, regionalt recidiv, fjernt recidiv, kontralateral anden primær invasiv cancer, anden primær ikke-brystkræft. invasiv cancer (eksklusive ikke-melanom hudkræft) eller død uden tegn på gentagelse. Fordelingen af DFS (f.eks. 5-års DFS-rate) estimeres ved hjælp af Kaplan-Meier-metoden og sammenlignes mellem de to randomiserede arme (arm B vs. arm C) ved hjælp af stratificeret log-rangtest og stratificeret Cox proportional hazard-model.	Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, DFS-sats estimeret til 5 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
5-års afstandsfrit gentagelsesinterval Tidsramme: Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, DRFI-sats estimeret til 5 år	Distant recidiv-free interval (DRFI) er defineret som tiden fra datoen for randomisering eller registrering til datoen for fjernt recidiv af brystkræft eller for død med fjernt recidiv, hvis døden er den første manifestation af fjernt recidiv. Fordelingen af DRFI (f.eks. 5-års DRFI-rate) estimeres ved hjælp af Kaplan-Meier-metoden.	Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, DRFI-sats estimeret til 5 år
5-års gentagelsesfrit interval Tidsramme: Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, RFS-rate estimeret til 5 år	Recidivfrit interval (RFS) er defineret som tiden fra datoen for randomisering eller registrering til datoen for første recidiv af brystkræft (ipsilateral brysttumor recidiv, lokalt/regionalt recidiv, fjernt recidiv) eller til datoen for død med recidiv, hvis døden er den første manifestation af gentagelse. Fordelingen af RFS (f.eks. 5-års RFS rate) estimeres ved hjælp af Kaplan-Meier metode.	Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, RFS-rate estimeret til 5 år
5-års samlet overlevelse Tidsramme: Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, OS-rate estimeret til 5 år	Samlet overlevelse (OS) er defineret som tiden fra dato for randomisering eller registrering til dato for død uanset årsag. Fordelingen af OS (f.eks. 5-års OS-rate) estimeres ved hjælp af Kaplan-Meier-metoden.	Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, OS-rate estimeret til 5 år
5-års sygdomsfri overlevelse efter alder og gentagelsesscoregrupper Tidsramme: Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, DFS-sats estimeret til 5 år	Sygdomsfri overlevelse (DFS) er defineret som tiden fra randomisering til første hændelse, hvor den første hændelse er en hvilken som helst af ipsilateral brysttumor-tilbagefald, lokalt recidiv, regionalt recidiv, fjernt recidiv, kontralateral anden primær invasiv cancer, anden primær ikke-brystkræft. invasiv cancer (eksklusive ikke-melanom hudkræft) eller død uden tegn på gentagelse. DFS evalueres efter recidivscore (0-10 vs. 11-15 vs. 16-20 vs. 21-25 vs. >25) og aldersgrupper (	Vurderet hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år, DFS-sats estimeret til 5 år
For at sammenligne de resultater, der forventes efter 10 år af adjuvans! Med dem lavet af Genomic Health Oncotype DX Test Tidsramme: Vurderet til 10 år efter studiestart	Adjuvans! er ikke tilgængelig i øjeblikket; yderligere arbejde, der kombinerer klassisk information med genomiske test, vil blive rapporteret separat.	Vurderet til 10 år efter studiestart
5-års sygdomsfri overlevelse af individuelle RS-gengrupper Tidsramme: Vurderes hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år	Sygdomsfri overlevelse (DFS) er defineret som tiden fra randomisering til første hændelse, hvor den første hændelse er en hvilken som helst af ipsilateral brysttumor-tilbagefald, lokalt recidiv, regionalt recidiv, fjernt recidiv, kontralateral anden primær invasiv cancer, anden primær ikke-brystkræft. invasiv cancer (eksklusive ikke-melanom hudkræft) eller død uden tegn på gentagelse. Fordelingen af DFS (f.eks. 5-års DFS rate) estimeres ved hjælp af Kaplan-Meier metode. 5-årig DFS af individuelle RS-gengrupper (Proliferation Gene Group, HER2 Gene Group, ER Gene Group, Invasion Gene Group og Other Geners) vil blive estimeret i hver arm.	Vurderes hver 6. måned inden for 5 år fra registrering og derefter årligt op til 20 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Samarbejdspartnere

NCIC Clinical Trials Group

Cancer and Leukemia Group B

North Central Cancer Treatment Group

NSABP Foundation Inc

American College of Surgeons

SWOG Cancer Research Network

Efterforskere

Ledende efterforsker: Joseph A Sparano, ECOG-ACRIN Cancer Research Group

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

7. april 2006

Primær færdiggørelse (Faktiske)

2. marts 2018

Studieafslutning (Anslået)

30. september 2030

Datoer for studieregistrering

Først indsendt

29. marts 2006

Først indsendt, der opfyldte QC-kriterier

29. marts 2006

Først opslået (Anslået)

3. april 2006

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

8. september 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

4. september 2026

Sidst verificeret

1. september 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

NCI-2009-00707 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
U10CA180820 (U.S. NIH-bevilling/kontrakt)
U10CA021115 (U.S. NIH-bevilling/kontrakt)
ECOG-PACCT-1
06-482
CDR0000472066
PACCT-1 (Anden identifikator: CTEP)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Hormonterapi med eller uden kombinationskemoterapi til behandling af kvinder, der er blevet opereret for node-negativ brystkræft (TAILORx-forsøget) (TAILORx)

Program til vurdering af kliniske kræfttest (PACCT-1): Forsøg, der tildeler individualiserede behandlingsmuligheder: TAILORx-forsøget

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Anslået)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre