Denne siden ble automatisk oversatt og nøyaktigheten av oversettelsen er ikke garantert. Vennligst referer til engelsk versjon for en kildetekst.

Hormonterapi med eller uten kombinasjonskjemoterapi ved behandling av kvinner som har gjennomgått kirurgi for node-negativ brystkreft (The TAILORx Trial) (TAILORx)

3. april 2024 oppdatert av: National Cancer Institute (NCI)

Program for vurdering av kliniske krefttester (PACCT-1): Forsøk som tildeler individuelle behandlingsalternativer: TAILORx-prøven

Denne randomiserte fase III studien studerer den beste individuelle behandlingen for kvinner som har node-negativ, østrogenreseptor positiv brystkreft ved å bruke en spesiell test (Oncotype DX), og om hormonbehandling alene eller hormonbehandling sammen med kombinasjonskjemoterapi er bedre for kvinner som har en Oncotype DX-residivscore på 11-25. Østrogen kan forårsake vekst av brystkreftceller. Hormonbehandling kan bekjempe brystkreft ved å blokkere bruken av østrogen av tumorcellene eller ved å redusere mengden østrogen kroppen lager. Legemidler som brukes i kjemoterapi virker på forskjellige måter for å stoppe veksten av tumorceller, enten ved å drepe cellene, ved å hindre dem i å dele seg, eller ved å hindre dem i å spre seg. Å gi hormonbehandling sammen med mer enn ett kjemoterapilegemiddel (kombinasjonskjemoterapi) har vist seg å redusere sjansen for tilbakefall av brystkreft, men fordelen av å legge kjemoterapi til hormonbehandling for kvinner med node-negativ, østrogenreseptorpositiv brystkreft er liten . Nye tester kan gi informasjon om hvilke pasienter som er mer sannsynlig å ha nytte av kjemoterapi.

Studieoversikt

Status

Aktiv, ikke rekrutterende

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

PRIMÆRE MÅL:

I. For å avgjøre om adjuvant hormonbehandling ikke er dårligere enn adjuvant kjemohormonell hos kvinner hvis svulster oppfyller etablerte kliniske retningslinjer for adjuvant kjemoterapi og faller i kategorien "primær studiegruppe" (Oncotype DX Recidiv Score 11-25).

II. Å lage en vevs- og prøvebank for pasienter som er registrert i denne studien, inkludert formalinfikserte parafininnstøpte tumorprøver, vevsmikroarrayer, plasma og deoksyribonukleinsyre (DNA) hentet fra perifert blod.

SEKUNDÆRE MÅL:

I. For å avgjøre om adjuvant hormonbehandling er tilstrekkelig behandling (dvs. 10 års fjern sykdomsfri overlevelse på minst 95%) for kvinner hvis svulster oppfyller etablerte kliniske retningslinjer for adjuvant kjemoterapi og som faller inn under kategorien "Sekundær studiegruppe-1" (Oncotype DX gjentakelsespoeng =< 10).

II. For å sammenligne resultatene projisert etter 10 år av Adjuvant (med utfall anslått ved bruk av klassisk patologisk informasjon inkludert tumorstørrelse, hormonreseptorstatus og histologisk karakter) med resultatene laget av Genomic Health Oncotype DX-testen. Klassisk patologisk informasjon og resultatresultater vil også bli brukt til å lage og avgrense modeller som vil bruke klassisk informasjon i stedet for eller i kombinasjon med genomiske tester.

III. Å estimere feilrater som en funksjon av residivscore (RS) separat i cellegiftgruppene (arm C, D) og ingen kjemoterapi (arm A, B). Hensikten med analysen er å utvikle mer presise estimater av sammenhengen mellom residivskår og eventuell kjemoterapibehandlingseffekt i det øvre området av RS 11 - 25-gruppen.

IV. For å bestemme den prognostiske betydningen av Oncotype DX-residivskåren og de individuelle RS-gengruppene (proliferasjonsgengruppe, human epidermal vekstfaktorreseptor [HER]2 gengruppe, østrogenreseptor [ER] gengruppe, invasjonsgengruppe og andre gener ).

TERTIÆRE MÅL:

I. Å evaluere effekten av kjemoterapi og hormonbehandling vs hormonbehandling alene på opplevd kognitiv svikt, tretthet, frykt for tilbakefall blant pre-menopausale pasienter, endokrine symptomer og seksuell dysfunksjon, og generell helserelatert livskvalitet (HRQL).

II. For å fastslå om opplevd kognitiv svikt, tretthet, frykt for tilbakefall, endokrine symptomer og generell HRQL er like for pasienter som får kjemoterapi pluss hormonbehandling i sekundær studiegruppe 2 som for de i primær studiegruppe (arm D vs C).

III. For å finne ut om opplevd kognitiv svikt, tretthet, frykt for tilbakefall, endokrine symptomer og generell HRQL er like for pasienter som får hormonbehandling alene i sekundær studiegruppe 1 som for de i primær studiegruppe (arm A vs B).

IV. For å avgjøre om alder vil være omvendt assosiert med frykt for tilbakefall, uavhengig av behandlingsoppdrag.

V. Blant deltakerne som mottar hormonbehandling alene på arm A og arm B, for å avgjøre om Oncotype DX-residivscore vil være omvendt korrelert med frykt for tilbakefall.

VI. Å lage et bioprøvelager inkludert plasma-, serum- og CellSearch-kassetter som inneholder sirkulerende tumorceller (CTC) for å evaluere determinanter for sent tilbakefall, inkludert kandidatbiomarkører som reflekterer okkult tumorbelastning (f.eks. CTC og plasmatumor-DNA) og vertsfaktorer (f.eks. østrogen, insulinvekstfaktor-[IGF]-akse, betennelse osv.).

VII. Å lage et biolager av metastatiske tumorprøver hos pasienter som har hatt et sent tilbakefall.

VIII. For å bestemme kroppsmasseindeks (BMI) og komorbiditetsbyrde hos pasienter med operabel brystkreft fem eller flere år etter diagnosen.

IX. For å fastslå om det er en sammenheng mellom sent tilbakefall og BMI ved diagnose og 5 år etter diagnose, og om BMI-assosierte inflammatoriske og/eller metabolske biomarkører er assosiert med tidlig og sent residiv.

OVERSIKT: Dette er en delvis randomisert studie. Pasientene tildeles 1 av 3 behandlingsgrupper.

GRUPPE 1 (SEKUNDÆR STUDIEGRUPPE 1; ONCOTYPE DX RESIURENSSCORE [ODRS] =< 10): Pasienter får standard hormonbehandling (f.eks. tamoxifen alene oralt (PO), aromatasehemmer [f.eks. anastrozol, letrozol eller exemestan] alene PO, eller tamoxifen PO etterfulgt av aromatasehemmer PO) etter den behandlende legens skjønn i 5 eller 10 år.

GRUPPE 2 (PRIMÆR STUDIEGRUPPE; ODRS 11-25): Pasienter randomiseres til å motta enten hormonbehandling alene eller kombinasjonskjemoterapi og hormonbehandling.

ARM I (EKSPERIMENTELL): Pasienter får hormonbehandling som i gruppe 1 etter den behandlende legens skjønn.

ARM II (STANDARD): Pasienter får standard kombinasjonskjemoterapi etter den behandlende legens skjønn. Innen 4 uker etter siste dose med kjemoterapi får pasientene hormonbehandling som i gruppe 1 etter den behandlende legens skjønn.

GRUPPE 3 (SEKUNDÆR STUDIEGRUPPE 2; ODRS >= 26): Pasienter får kombinasjonskjemoterapi som i gruppe 2, arm II etterfulgt av hormonbehandling som i gruppe 1.

Pasienter i alle grupper som har fått brystbevarende operasjoner behandles også med strålebehandling. Strålebehandling bør starte innen 4 uker etter registrering for pasienter som får hormonbehandling alene eller innen 8 uker etter fullført kjemoterapi. Pasienter som deltar i National Surgical Adjuvant Breast and Bowel Project (NSABP) og/eller Radiation Therapy Oncology Group (RTOG) delvis bestrålingsforsøk(er) kan motta delvis bryststråling.

Etter avsluttet studiebehandling følges pasientene opp hver 3.-6. måned i 5 år og deretter årlig i 15 år.

Studietype

Intervensjonell

Registrering (Faktiske)

10273

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Australia
- New South Wales
  - Albury, New South Wales, Australia, 2640
    - Border Medical Oncology
  - Coffs Harbour, New South Wales, Australia, 2450
    - Coffs Harbour Health Campus-North Coast Cancer Institute
  - Concord, New South Wales, Australia, 2139
    - Concord Repatriation General Hospital
  - Lismore, New South Wales, Australia, 2480
    - Lismore Base Hospital
  - Merewether, New South Wales, Australia, 2191
    - Lingard Private Hospital
  - New Castle, New South Wales, Australia, 2300
    - Royal Newcastle Hospital
  - Waratah, New South Wales, Australia, 2310
    - Calvary Mater Newcastle Hospital
- Queensland
  - Herston, Queensland, Australia, 4029
    - Royal Brisbane and Women's Hospital
  - Nambour, Queensland, Australia, 4560
    - Nambour Hospital
- Tasmania
  - Saint Hobart, Tasmania, Australia, 7000
    - Royal Hobart Hospital
- Victoria
  - East Melbourne, Victoria, Australia, 3002
    - Breast Unit-Mercy Private
  - Richmond, Victoria, Australia, 3121
    - Epworth Hospital
- Western Australia
  - Bunbury, Western Australia, Australia, 6230
    - Saint John of God Hospital - Bunbury
  - Nedlands, Western Australia, Australia, 6009
    - Sir Charles Gairdner Hospital
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N 4N2
    - Tom Baker Cancer Centre
- British Columbia
  - Kelowna, British Columbia, Canada, V1Y 5L3
    - BCCA-Cancer Centre for the Southern Interior
  - Penticton, British Columbia, Canada, V2A 3G6
    - Penticton Regional Hospital
  - Surrey, British Columbia, Canada, V3V 1Z2
    - BCCA-Fraser Valley Cancer Centre
  - Vancouver, British Columbia, Canada, V5Z 4E6
    - BCCA-Vancouver Cancer Centre
  - Victoria, British Columbia, Canada, V8R 6V5
    - BCCA-Vancouver Island Cancer Centre
- Manitoba
  - Winnipeg, Manitoba, Canada, R3E 0V9
    - CancerCare Manitoba
- New Brunswick
  - Moncton, New Brunswick, Canada, E1C 6Z8
    - The Moncton Hospital
  - Saint John, New Brunswick, Canada, E2L 4L2
    - Atlantic Health Sciences Corporation-Saint John Regional Hospital
- Ontario
  - Mississauga, Ontario, Canada, L5M 2N1
    - Trillium Health Partners - Credit Valley Hospital
  - Sudbury, Ontario, Canada, P3E 5J1
    - Health Sciences North
  - Thunder Bay, Ontario, Canada, P7B 6V4
    - Thunder Bay Regional Health Science Centre
  - Toronto, Ontario, Canada, M4N 3M5
    - Odette Cancer Centre- Sunnybrook Health Sciences Centre
  - Toronto, Ontario, Canada, M5B 1W8
    - Saint Michael's Hospital
  - Toronto, Ontario, Canada, M4C 3E7
    - Michael Garron Hospital
  - Toronto, Ontario, Canada, M9C 1A5
    - Trillium Health Partners - Queensway Health Centre
  - Windsor, Ontario, Canada, N8W 2X3
    - Windsor Regional Cancer Centre
- Quebec
  - Greenfield Park, Quebec, Canada, J4V 2H1
    - CSSS Champlain-Charles Le Moyne
  - Montreal, Quebec, Canada, H3T 1E2
    - Jewish General Hospital
  - Montreal, Quebec, Canada, H3H 2R9
    - The Research Institute of the McGill University Health Centre (MUHC)
  - Montreal, Quebec, Canada, H2L 4M1
    - CHUM - Hopital Notre-Dame
  - Montreal, Quebec, Canada, H2W 1S6
    - McGill University Department of Oncology
  - Montreal, Quebec, Canada, H2W 1T8
    - CHUM-Hotel Dieu de Montreal
  - Montreal, Quebec, Canada, H2X 3E4
    - CHUM - Centre Hospitalier de l'Universite de Montreal
  - Montreal, Quebec, Canada, H1T 2M4
    - CIUSSSEMTL-Hopital Maisonneuve-Rosemont
  - Quebec City, Quebec, Canada, G1S 4L8
    - CHU de Quebec-Hopital du Saint-Sacrement (HSS)
- Saskatchewan
  - Regina, Saskatchewan, Canada, S4T 7T1
    - Allan Blair Cancer Centre
  - Saskatoon, Saskatchewan, Canada, S7N 4H4
    - Saskatoon Cancer Centre
Forente stater
- Alabama
  - Anniston, Alabama, Forente stater, 36202
    - Northeast Alabama Regional Medical Center
  - Birmingham, Alabama, Forente stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Mobile, Alabama, Forente stater, 36688
    - University of South Alabama Mitchell Cancer Institute
  - Mobile, Alabama, Forente stater, 36608
    - Providence Hospital
  - Mobile, Alabama, Forente stater, 36607
    - Mobile Infirmary Medical Center
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Regional Hospital
  - Fairbanks, Alaska, Forente stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Glendale, Arizona, Forente stater, 85306
    - Banner Thunderbird Medical Center
  - Mesa, Arizona, Forente stater, 85202
    - Banner Desert Medical Center
  - Mesa, Arizona, Forente stater, 85206
    - Banner Baywood Medical Center
  - Phoenix, Arizona, Forente stater, 85006
    - Banner-University Medical Center Phoenix
  - Phoenix, Arizona, Forente stater, 85006
    - Western Regional CCOP
  - Scottsdale, Arizona, Forente stater, 85258
    - Virginia G Piper Cancer Care-Del Camino
  - Tucson, Arizona, Forente stater, 85719
    - Banner University Medical Center - Tucson
- Arkansas
  - Fort Smith, Arkansas, Forente stater, 72903
    - Mercy Hospital Fort Smith
  - Fort Smith, Arkansas, Forente stater, 72901
    - Sparks Regional Medical Center
  - Hot Springs, Arkansas, Forente stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forente stater, 72401
    - NEA Baptist Memorial Hospital
  - Jonesboro, Arkansas, Forente stater, 72401
    - Saint Bernards Regional Medical Center
  - Little Rock, Arkansas, Forente stater, 72205
    - University of Arkansas for Medical Sciences
- California
  - Arroyo Grande, California, Forente stater, 93420
    - PCR Oncology
  - Arroyo Grande, California, Forente stater, 93420
    - Arroyo Grande Community
  - Berkeley, California, Forente stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forente stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forente stater, 94010
    - Mills-Peninsula Medical Center
  - Castro Valley, California, Forente stater, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Forente stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forente stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Chico, California, Forente stater, 95926
    - Enloe Medical Center
  - Clovis, California, Forente stater, 93611
    - Community Cancer Institute
  - Concord, California, Forente stater, 94520
    - John Muir Medical Center-Concord Campus
  - Duarte, California, Forente stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Emeryville, California, Forente stater, 94608
    - Bay Area Breast Surgeons Inc
  - Fremont, California, Forente stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forente stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fremont, California, Forente stater, 94538
    - Washington Hospital
  - Fresno, California, Forente stater, 93720
    - California Cancer Associates for Research and Excellence (cCare)
  - Fullerton, California, Forente stater, 92835
    - Saint Jude Medical Center
  - Glendale, California, Forente stater, 91204
    - Glendale Memorial Hospital and Health Center
  - Greenbrae, California, Forente stater, 94904
    - Marin Cancer Care Inc
  - Greenbrae, California, Forente stater, 94904
    - Marin General Hospital
  - Hayward, California, Forente stater, 94545
    - Saint Rose Hospital
  - La Jolla, California, Forente stater, 92093
    - UC San Diego Moores Cancer Center
  - La Jolla, California, Forente stater, 92037
    - Scripps Green Hospital
  - Loma Linda, California, Forente stater, 92354
    - Loma Linda University Medical Center
  - Long Beach, California, Forente stater, 90806
    - Long Beach Memorial Medical Center-Todd Cancer Institute
  - Los Angeles, California, Forente stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forente stater, 90095
    - UCLA / Jonsson Comprehensive Cancer Center
  - Martinez, California, Forente stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forente stater, 95901
    - Fremont - Rideout Cancer Center
  - Mission Hills, California, Forente stater, 91346-9600
    - Providence Holy Cross Medical Center
  - Modesto, California, Forente stater, 95355
    - Memorial Medical Center
  - Monterey, California, Forente stater, 93940
    - Community Hospital of Monterey Peninsula
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Northridge, California, Forente stater, 91325
    - Northridge Hospital Medical Center
  - Novato, California, Forente stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forente stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forente stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forente stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forente stater, 94602
    - Highland General Hospital
  - Oakland, California, Forente stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forente stater, 94609
    - Bay Area Tumor Institute
  - Orange, California, Forente stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Orange, California, Forente stater, 92868
    - Saint Joseph Hospital - Orange
  - Palm Springs, California, Forente stater, 92262
    - Desert Regional Medical Center
  - Palo Alto, California, Forente stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Pleasanton, California, Forente stater, 94588
    - Valley Care Health System - Pleasanton
  - Pleasanton, California, Forente stater, 94588
    - Valley Medical Oncology Consultants
  - Pomona, California, Forente stater, 91767
    - Pomona Valley Hospital Medical Center
  - Redding, California, Forente stater, 96001
    - Mercy Regional Cancer Center
  - Redwood City, California, Forente stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forente stater, 94801
    - Kaiser Permanente-Richmond
  - Roseville, California, Forente stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forente stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forente stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forente stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forente stater, 95825
    - Kaiser Permanente - Sacramento
  - Sacramento, California, Forente stater, 95819
    - Mercy General Hospital
  - Salinas, California, Forente stater, 93901
    - Salinas Valley Memorial
  - San Diego, California, Forente stater, 92134
    - Naval Medical Center -San Diego
  - San Diego, California, Forente stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Diego, California, Forente stater, 92123
    - Sharp Memorial Hospital
  - San Diego, California, Forente stater, 92103
    - UC San Diego Medical Center - Hillcrest
  - San Diego, California, Forente stater, 92161
    - San Diego VA Medical Center
  - San Francisco, California, Forente stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forente stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forente stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forente stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forente stater, 94577
    - Kaiser Permanente San Leandro
  - San Pablo, California, Forente stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - San Rafael, California, Forente stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Ana, California, Forente stater, 92705
    - Breastlink Medical Group Inc
  - Santa Barbara, California, Forente stater, 93105
    - Cancer Center of Santa Barbara
  - Santa Barbara, California, Forente stater, 93105
    - Ridley-Tree Cancer Center
  - Santa Barbara, California, Forente stater, 93105
    - Sansum Clinic Inc
  - Santa Barbara, California, Forente stater, 93111
    - Ray, Margaret, Savage. M.D. (UIA Investigator)
  - Santa Clara, California, Forente stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Rosa, California, Forente stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forente stater, 95405
    - Providence Santa Rosa Memorial Hospital
  - Solvang, California, Forente stater, 93463
    - Ridley-Tree Cancer Center-Solvang
  - South San Francisco, California, Forente stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forente stater, 95210
    - Kaiser Permanente-Stockton
  - Sylmar, California, Forente stater, 91342
    - Olive View-University of California Los Angeles Medical Center
  - Torrance, California, Forente stater, 90509
    - Torrance Memorial Medical Center
  - Turlock, California, Forente stater, 95382
    - Emanuel Medical Center
  - Vacaville, California, Forente stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forente stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forente stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forente stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forente stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Walnut Creek, California, Forente stater, 94598
    - John Muir Medical Center-Walnut Creek
  - Whittier, California, Forente stater, 90602
    - Presbyterian Intercommunity Hospital
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forente stater, 80045
    - Rocky Mountain Regional VA Medical Center
  - Aurora, Colorado, Forente stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forente stater, 80301
    - Boulder Community Hospital
  - Colorado Springs, Colorado, Forente stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forente stater, 80909
    - UCHealth Memorial Hospital Central
  - Denver, Colorado, Forente stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forente stater, 80217-3364
    - University of Colorado
  - Denver, Colorado, Forente stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forente stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80222
    - Western States Cancer Research NCORP
  - Edwards, Colorado, Forente stater, 81632
    - Shaw Cancer Center
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forente stater, 80524
    - Poudre Valley Hospital
  - Grand Junction, Colorado, Forente stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forente stater, 80631
    - North Colorado Medical Center
  - Lafayette, Colorado, Forente stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forente stater, 80228
    - Saint Anthony Hospital
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Longmont, Colorado, Forente stater, 80501
    - Longmont United Hospital
  - Loveland, Colorado, Forente stater, 80539
    - McKee Medical Center
  - Montrose, Colorado, Forente stater, 81401
    - Montrose Memorial Hospital
  - Pueblo, Colorado, Forente stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forente stater, 80229
    - North Suburban Medical Center
  - Wheat Ridge, Colorado, Forente stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Bridgeport, Connecticut, Forente stater, 06610
    - Bridgeport Hospital
  - Bridgeport, Connecticut, Forente stater, 06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Danbury, Connecticut, Forente stater, 06810
    - Danbury Hospital
  - Farmington, Connecticut, Forente stater, 06030
    - University of Connecticut
  - Greenwich, Connecticut, Forente stater, 06830
    - Greenwich Hospital
  - Hartford, Connecticut, Forente stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forente stater, 06102
    - Hartford Hospital
  - Manchester, Connecticut, Forente stater, 06040
    - Manchester Memorial Hospital
  - Middletown, Connecticut, Forente stater, 06457
    - Middlesex Hospital
  - New Britain, Connecticut, Forente stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forente stater, 06520
    - Yale University
  - New Haven, Connecticut, Forente stater, 06511
    - Yale-New Haven Hospital Saint Raphael Campus
  - Norwich, Connecticut, Forente stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Stamford, Connecticut, Forente stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Torrington, Connecticut, Forente stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Waterbury, Connecticut, Forente stater, 06708
    - Harold Leever Regional Cancer Center
- Delaware
  - Dover, Delaware, Forente stater, 19901
    - Bayhealth Hospital Kent Campus
  - Lewes, Delaware, Forente stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forente stater, 19718
    - Christiana Care Health System-Christiana Hospital
- District of Columbia
  - Washington, District of Columbia, Forente stater, 20010
    - MedStar Washington Hospital Center
  - Washington, District of Columbia, Forente stater, 20007
    - Medstar Georgetown University Hospital
  - Washington, District of Columbia, Forente stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forente stater, 20037
    - George Washington University Medical Center
- Florida
  - Boca Raton, Florida, Forente stater, 33486
    - Boca Raton Regional Hospital
  - Boca Raton, Florida, Forente stater, 33428
    - Lynn Regional Cancer Center - West
  - Boca Raton, Florida, Forente stater, 33486
    - Boca Raton Comprehensive Cancer Center
  - Daytona Beach, Florida, Forente stater, 32114
    - Halifax Health Medical Center-Centers for Oncology
  - Deerfield Beach, Florida, Forente stater, 33064
    - Broward Health North
  - Fort Lauderdale, Florida, Forente stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forente stater, 33308
    - Holy Cross Hospital
  - Gainesville, Florida, Forente stater, 32610
    - University of Florida Health Science Center - Gainesville
  - Hollywood, Florida, Forente stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forente stater, 32207
    - Baptist MD Anderson Cancer Center
  - Jacksonville, Florida, Forente stater, 32224-9980
    - Mayo Clinic in Florida
  - Jacksonville, Florida, Forente stater, 32204
    - Saint Vincent's Medical Center
  - Jupiter, Florida, Forente stater, 33458
    - Jupiter Medical Center
  - Lakeland, Florida, Forente stater, 33805
    - Lakeland Regional Health Hollis Cancer Center
  - Lakeland, Florida, Forente stater, 33805
    - The Watson Clinic
  - Leesburg, Florida, Forente stater, 34788
    - Cancer Centers of Central Florida PA
  - Miami, Florida, Forente stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Forente stater, 33176
    - Miami Cancer Institute
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center
  - Orange Park, Florida, Forente stater, 32073
    - 21st Century Oncology-Orange Park
  - Orlando, Florida, Forente stater, 32806
    - Orlando Health Cancer Institute
  - Orlando, Florida, Forente stater, 32803
    - AdventHealth Orlando
  - Pensacola, Florida, Forente stater, 32504
    - Sacred Heart Hospital
  - Sarasota, Florida, Forente stater, 34236
    - Florida Cancer Specialists - Sarasota Downtown
  - Stuart, Florida, Forente stater, 34994
    - Martin Medical Center
  - Stuart, Florida, Forente stater, 34994
    - Robert and Carol Weissman Cancer Center at Martin Health
  - Stuart, Florida, Forente stater, 34997
    - Martin Hospital South
  - Titusville, Florida, Forente stater, 32796
    - Space Coast Cancer Centers-Titusville
  - Weston, Florida, Forente stater, 33331
    - Cleveland Clinic-Weston
- Georgia
  - Albany, Georgia, Forente stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forente stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forente stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forente stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forente stater, 30303
    - Grady Health System
  - Atlanta, Georgia, Forente stater, 30309
    - Piedmont Hospital
  - Atlanta, Georgia, Forente stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forente stater, 30342
    - Atlanta Regional CCOP
  - Augusta, Georgia, Forente stater, 30912
    - Augusta University Medical Center
  - Augusta, Georgia, Forente stater, 30901
    - Augusta Oncology Associates PC-D'Antignac
  - Austell, Georgia, Forente stater, 30106
    - WellStar Cobb Hospital
  - Columbus, Georgia, Forente stater, 31904
    - John B Amos Cancer Center
  - Decatur, Georgia, Forente stater, 30033
    - Dekalb Medical Center
  - Gainesville, Georgia, Forente stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Forente stater, 30046
    - Northside Hospital - Gwinnett
  - Macon, Georgia, Forente stater, 31201
    - Medical Center of Central Georgia
  - Marietta, Georgia, Forente stater, 30060
    - WellStar Kennestone Hospital
  - Riverdale, Georgia, Forente stater, 30274
    - Southern Regional Medical Center
  - Rome, Georgia, Forente stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forente stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forente stater, 31404
    - Memorial Health University Medical Center
  - Valdosta, Georgia, Forente stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - 'Aiea, Hawaii, Forente stater, 96701
    - Pali Momi Medical Center
  - Honolulu, Hawaii, Forente stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forente stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forente stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forente stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forente stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forente stater, 96859
    - Tripler Army Medical Center
  - Wailuku, Hawaii, Forente stater, 96793
    - Maui Memorial Medical Center
  - Wailuku, Hawaii, Forente stater, 96793
    - Pacific Cancer Institute of Maui
- Idaho
  - Boise, Idaho, Forente stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forente stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Pocatello, Idaho, Forente stater, 83201
    - Portneuf Medical Center
  - Post Falls, Idaho, Forente stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
- Illinois
  - Alton, Illinois, Forente stater, 62002
    - Saint Anthony's Health
  - Arlington Heights, Illinois, Forente stater, 60005
    - Northwest Community Hospital
  - Aurora, Illinois, Forente stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forente stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forente stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forente stater, 61520
    - Graham Hospital Association
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forente stater, 62321
    - Memorial Hospital
  - Chicago, Illinois, Forente stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forente stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forente stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forente stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forente stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forente stater, 60657
    - UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
  - Chicago, Illinois, Forente stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forente stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forente stater, 60611
    - Hematology and Oncology Associates
  - Chicago, Illinois, Forente stater, 60631
    - Presence Resurrection Medical Center
  - Chicago, Illinois, Forente stater, 60640
    - Weiss Memorial Hospital
  - Chicago, Illinois, Forente stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Chicago, Illinois, Forente stater, 60616
    - Mercy Hospital and Medical Center
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forente stater, 62526
    - Heartland Cancer Research NCORP
  - Elk Grove Village, Illinois, Forente stater, 60007
    - Ascension Alexian Brothers - Elk Grove Village
  - Elmhurst, Illinois, Forente stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forente stater, 61530
    - Eureka Hospital
  - Evanston, Illinois, Forente stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forente stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Galesburg
  - Galesburg, Illinois, Forente stater, 61401
    - Galesburg Cottage Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Cottage
  - Geneva, Illinois, Forente stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Geneva, Illinois, Forente stater, 60134
    - LaGrange Oncology Associates
  - Harvey, Illinois, Forente stater, 60426
    - Ingalls Memorial Hospital
  - Havana, Illinois, Forente stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forente stater, 62644
    - Illinois CancerCare-Havana
  - Hinsdale, Illinois, Forente stater, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Hopedale, Illinois, Forente stater, 61747
    - Hopedale Medical Complex - Hospital
  - Joliet, Illinois, Forente stater, 60435
    - Duly Health and Care Joliet
  - Joliet, Illinois, Forente stater, 60432
    - Midwest Center for Hematology Oncology
  - Kankakee, Illinois, Forente stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Kewanee, Illinois, Forente stater, 61443
    - Kewanee Hospital
  - La Grange, Illinois, Forente stater, 60525
    - AMITA Health Adventist Medical Center
  - Libertyville, Illinois, Forente stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forente stater, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, Forente stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forente stater, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Porubcin, Michael MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Trinity Medical Center
  - Moline, Illinois, Forente stater, 61265
    - Sharis, Christine M MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Stoffel, Thomas J MD (UIA Investigator)
  - Moline, Illinois, Forente stater, 61265
    - Vigliotti, Antonio, P.G. M.D. (UIA Investigator)
  - Monmouth, Illinois, Forente stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forente stater, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Forente stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forente stater, 60540
    - Edward Hospital/Cancer Center
  - Niles, Illinois, Forente stater, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Forente stater, 61761
    - Carle Cancer Institute Normal
  - Normal, Illinois, Forente stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forente stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Normal, Illinois, Forente stater, 61761
    - Mid-Illinois Hematology Oncology Associates Limited
  - Oak Lawn, Illinois, Forente stater, 60453-2699
    - Advocate Christ Medical Center
  - Olympia Fields, Illinois, Forente stater, 60461
    - Franciscan St. James Health-Olympia Fields Campus
  - Ottawa, Illinois, Forente stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forente stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Park Ridge, Illinois, Forente stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forente stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forente stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Pekin, Illinois, Forente stater, 61554
    - Pekin Hospital
  - Peoria, Illinois, Forente stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forente stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forente stater, 61614
    - Proctor Hospital
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forente stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forente stater, 61356
    - Perry Memorial Hospital
  - River Forest, Illinois, Forente stater, 60305
    - West Suburban Medical Center
  - Rockford, Illinois, Forente stater, 61108
    - OSF Saint Anthony Medical Center
  - Rockford, Illinois, Forente stater, 61104
    - Swedish American Hospital
  - Skokie, Illinois, Forente stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Skokie, Illinois, Forente stater, 60076
    - Edward H Kaplan MD and Associates
  - Skokie, Illinois, Forente stater, 60077
    - Midwest Cancer Research Group Incorporated
  - Spring Valley, Illinois, Forente stater, 61362
    - Saint Margaret's Hospital
  - Spring Valley, Illinois, Forente stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forente stater, 62781
    - Memorial Medical Center
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Winfield, Illinois, Forente stater, 60190
    - Northwestern Medicine Central DuPage Hospital
- Indiana
  - Anderson, Indiana, Forente stater, 46016
    - Ascension Saint Vincent Anderson
  - Beech Grove, Indiana, Forente stater, 46107
    - Franciscan Saint Francis Health-Beech Grove
  - Bloomington, Indiana, Forente stater, 47408
    - IU Health Bloomington
  - Elkhart, Indiana, Forente stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forente stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forente stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Goshen, Indiana, Forente stater, 46526
    - Goshen Center for Cancer Care
  - Indianapolis, Indiana, Forente stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forente stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forente stater, 46219
    - Community Cancer Center East
  - Indianapolis, Indiana, Forente stater, 46256
    - Community Cancer Center North
  - Indianapolis, Indiana, Forente stater, 46260
    - Ascension Saint Vincent Indianapolis Hospital
  - Indianapolis, Indiana, Forente stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Kokomo, Indiana, Forente stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forente stater, 46350
    - IU Health La Porte Hospital
  - Lafayette, Indiana, Forente stater, 47904
    - IU Health Arnett Cancer Care
  - Lafayette, Indiana, Forente stater, 47905
    - Horizon Oncology Research LLC
  - Merrillville, Indiana, Forente stater, 46410
    - Premier Oncology Hematology Associates
  - Michigan City, Indiana, Forente stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Mishawaka, Indiana, Forente stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Muncie, Indiana, Forente stater, 47303
    - IU Health Ball Memorial Hospital
  - Munster, Indiana, Forente stater, 46321
    - The Community Hospital
  - Richmond, Indiana, Forente stater, 47374
    - Reid Health
  - South Bend, Indiana, Forente stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forente stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forente stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forente stater, 46617
    - South Bend Clinic
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Forente stater, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Forente stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Cedar Rapids, Iowa, Forente stater, 52402
    - Saint Luke's Hospital
  - Cedar Rapids, Iowa, Forente stater, 52402
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forente stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forente stater, 51503
    - Heartland Oncology and Hematology LLP
  - Davenport, Iowa, Forente stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forente stater, 52804
    - Genesis Cancer Care Institute
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forente stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forente stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forente stater, 50314
    - Mission Cancer and Blood - Laurel
  - Des Moines, Iowa, Forente stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forente stater, 50307
    - Mercy Capitol
  - Dubuque, Iowa, Forente stater, 52001
    - Finley Hospital
  - Dubuque, Iowa, Forente stater, 52001
    - Medical Associates Clinic PC
  - Mason City, Iowa, Forente stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forente stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forente stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forente stater, 51102
    - Mercy Medical Center-Sioux City
  - Sioux City, Iowa, Forente stater, 51104
    - Saint Luke's Regional Medical Center
  - Waterloo, Iowa, Forente stater, 50701
    - Cedar Valley Medical Specialists
  - Waterloo, Iowa, Forente stater, 50702
    - MercyOne Waterloo Cancer Center
- Kansas
  - Chanute, Kansas, Forente stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forente stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forente stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Independence, Kansas, Forente stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forente stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forente stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forente stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forente stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forente stater, 67905
    - Cancer Center of Kansas-Liberal
  - Liberal, Kansas, Forente stater, 67901
    - Southwest Medical Center
  - Newton, Kansas, Forente stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forente stater, 66061
    - Olathe Health Cancer Center
  - Olathe, Kansas, Forente stater, 66061
    - Olathe Cancer Center
  - Overland Park, Kansas, Forente stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forente stater, 66213
    - Saint Luke's South Hospital
  - Overland Park, Kansas, Forente stater, 66210
    - Radiation Oncology Practice Corporation Southwest
  - Parsons, Kansas, Forente stater, 67357
    - Cancer Center of Kansas - Parsons
  - Prairie Village, Kansas, Forente stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forente stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forente stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forente stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forente stater, 66204
    - Advent Health - Shawnee Mission Medical Center
  - Topeka, Kansas, Forente stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Topeka, Kansas, Forente stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Wellington, Kansas, Forente stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forente stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forente stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Winfield, Kansas, Forente stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forente stater, 41101
    - King's Daughter's Medical Center
  - Ashland, Kentucky, Forente stater, 41101
    - Our Lady Bellefonte Hospital
  - Lexington, Kentucky, Forente stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forente stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forente stater, 40202
    - The James Graham Brown Cancer Center at University of Louisville
  - Louisville, Kentucky, Forente stater, 40207
    - Baptist Health Louisville
  - Madisonville, Kentucky, Forente stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Owensboro, Kentucky, Forente stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
- Louisiana
  - Alexandria, Louisiana, Forente stater, 71301
    - Christus Saint Frances Cabrini Hospital
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forente stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forente stater, 70806
    - Baton Rouge General Medical Center
  - Covington, Louisiana, Forente stater, 70433
    - Ochsner Health Center-Covington
  - Metairie, Louisiana, Forente stater, 70006
    - Metairie Oncologists
  - Monroe, Louisiana, Forente stater, 71202
    - Ochsner LSU Health Monroe Medical Center
  - New Orleans, Louisiana, Forente stater, 70112
    - Tulane University School of Medicine
  - New Orleans, Louisiana, Forente stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forente stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forente stater, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Forente stater, 71103
    - LSU Health Sciences Center at Shreveport
  - Shreveport, Louisiana, Forente stater, 71105
    - Highland Clinic
  - Shreveport, Louisiana, Forente stater, 71105
    - CHRISTUS Highland Medical Center
  - Shreveport, Louisiana, Forente stater, 71101
    - Overton Brooks Veteran's Administration Medical Center
- Maine
  - Augusta, Maine, Forente stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forente stater, 04401
    - Eastern Maine Medical Center
  - Lewiston, Maine, Forente stater, 04240
    - Central Maine Medical Center
  - Lewiston, Maine, Forente stater, 04240
    - Saint Mary's Regional Medical Center
  - Portland, Maine, Forente stater, 04101
    - Mercy Hospital
  - Scarborough, Maine, Forente stater, 04074
    - Maine Medical Center- Scarborough Campus
  - Scarborough, Maine, Forente stater, 04074
    - Maine Center for Cancer Medicine-Scarborough
  - Waterville, Maine, Forente stater, 04901
    - Maine General Medical Center-Thayer
  - York, Maine, Forente stater, 03909
    - York Hospital
- Maryland
  - Annapolis, Maryland, Forente stater, 21401
    - Anne Arundel Medical Center
  - Baltimore, Maryland, Forente stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forente stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forente stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forente stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forente stater, 21202
    - Mercy Medical Center
  - Baltimore, Maryland, Forente stater, 21218
    - MedStar Union Memorial Hospital
  - Baltimore, Maryland, Forente stater, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Forente stater, 21239
    - MedStar Good Samaritan Hospital
  - Bethesda, Maryland, Forente stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Bethesda, Maryland, Forente stater, 20814
    - Suburban Hospital
  - Cumberland, Maryland, Forente stater, 21502
    - UPMC Western Maryland
  - Easton, Maryland, Forente stater, 21601
    - University of Maryland Shore Medical Center at Easton
  - Elkton, Maryland, Forente stater, 21921
    - Christiana Care - Union Hospital
  - Frederick, Maryland, Forente stater, 21701
    - Frederick Memorial Hospital
  - Kensington, Maryland, Forente stater, 20895
    - Associates in Oncology Hematology PC -Kensington
  - Rockville, Maryland, Forente stater, 20850
    - Maryland Oncology Hematology PA-Aquilino Cancer Center
  - Salisbury, Maryland, Forente stater, 21801
    - TidalHealth Peninsula Regional
  - Silver Spring, Maryland, Forente stater, 20910
    - Holy Cross Hospital
  - Towson, Maryland, Forente stater, 21204
    - UM Saint Joseph Medical Center
- Massachusetts
  - Attleboro, Massachusetts, Forente stater, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, Forente stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forente stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forente stater, 02115
    - Brigham and Women's Hospital
  - Boston, Massachusetts, Forente stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forente stater, 02118
    - Boston Medical Center
  - Boston, Massachusetts, Forente stater, 02114
    - Massachusetts General Hospital Cancer Center
  - Brighton, Massachusetts, Forente stater, 02135
    - Steward Saint Elizabeth's Medical Center
  - Burlington, Massachusetts, Forente stater, 01805
    - Lahey Hospital and Medical Center
  - Concord, Massachusetts, Forente stater, 01742
    - Commonwealth Hematology Oncology PC-Concord
  - Danvers, Massachusetts, Forente stater, 01923
    - Mass General/North Shore Cancer Center
  - Dorchester, Massachusetts, Forente stater, 02124
    - Dana Farber Community Cancer Care-Dorchester
  - Fall River, Massachusetts, Forente stater, 02721
    - Saint Anne's Hospital
  - Fitchburg, Massachusetts, Forente stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Framingham, Massachusetts, Forente stater, 01702
    - MetroWest Medical Center-Framingham Union Hospital
  - Gloucester, Massachusetts, Forente stater, 01930
    - Addison Gilbert Hospital
  - Haverhill, Massachusetts, Forente stater, 01830
    - Dana Farber Community Cancer Care-Haverhill
  - Hyannis, Massachusetts, Forente stater, 02601
    - Cape Cod Hospital
  - Leominster, Massachusetts, Forente stater, 01453
    - HealthAlliance Hospital - Leominster
  - Lowell, Massachusetts, Forente stater, 01854
    - Lowell General Hospital
  - Lowell, Massachusetts, Forente stater, 01852
    - Saints Memorial Medical Center
  - Methuen, Massachusetts, Forente stater, 01844
    - Holy Family Hospital
  - Methuen, Massachusetts, Forente stater, 01844
    - Dana Farber-Merrimack Valley
  - Norwood, Massachusetts, Forente stater, 02062
    - Norwood Hospital
  - Pittsfield, Massachusetts, Forente stater, 01201
    - Berkshire Medical Center - Cancer Center
  - Quincy, Massachusetts, Forente stater, 02169
    - Dana Farber Community Cancer Care-Quincy
  - South Weymouth, Massachusetts, Forente stater, 02190
    - South Shore Hospital
  - Springfield, Massachusetts, Forente stater, 01199
    - Baystate Medical Center
  - Stoneham, Massachusetts, Forente stater, 02180
    - Dana Farber Community Cancer Care-Stoneham
  - Taunton, Massachusetts, Forente stater, 02780
    - Morton Hospital and Medical Center
  - Weymouth, Massachusetts, Forente stater, 02189
    - Dana Farber Community Cancer Care-Weymouth
  - Worcester, Massachusetts, Forente stater, 01655
    - UMass Memorial Medical Center - University Campus
  - Worcester, Massachusetts, Forente stater, 01606
    - Reliant Medical Group Inc
  - Worcester, Massachusetts, Forente stater, 01605
    - Commonwealth Hematology Oncology PC-Worcester
- Michigan
  - Adrian, Michigan, Forente stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forente stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48106
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forente stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forente stater, 48706
    - McLaren Cancer Institute-Bay City
  - Big Rapids, Michigan, Forente stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Dearborn, Michigan, Forente stater, 48124
    - Beaumont Hospital - Dearborn
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forente stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forente stater, 48236
    - Ascension Saint John Hospital
  - East Lansing, Michigan, Forente stater, 48824
    - Michigan State University Clinical Center
  - Escanaba, Michigan, Forente stater, 49829
    - Green Bay Oncology - Escanaba
  - Flint, Michigan, Forente stater, 48532
    - Genesys Regional Medical Center-West Flint Campus
  - Flint, Michigan, Forente stater, 48532
    - McLaren Cancer Institute-Flint
  - Flint, Michigan, Forente stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forente stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forente stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forente stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Grand Rapids, Michigan, Forente stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Holland, Michigan, Forente stater, 49423
    - Holland Community Hospital
  - Iron Mountain, Michigan, Forente stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forente stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forente stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forente stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forente stater, 49048
    - Borgess Medical Center
  - Lansing, Michigan, Forente stater, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Forente stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Forente stater, 48446
    - Lapeer Regional Hospital
  - Livonia, Michigan, Forente stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Marquette, Michigan, Forente stater, 49855
    - UP Health System Marquette
  - Midland, Michigan, Forente stater, 48670
    - MyMichigan Medical Center Midland
  - Monroe, Michigan, Forente stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Mount Clemens, Michigan, Forente stater, 48043
    - McLaren Cancer Institute-Macomb
  - Muskegon, Michigan, Forente stater, 49442
    - Mercy Health Partners-Hackley Campus
  - Muskegon, Michigan, Forente stater, 49444
    - Trinity Health Muskegon Hospital
  - Petoskey, Michigan, Forente stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forente stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forente stater, 48060
    - Lake Huron Medical Center
  - Rochester, Michigan, Forente stater, 48307
    - Crittenton Hospital
  - Royal Oak, Michigan, Forente stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forente stater, 48601
    - Ascension Saint Mary's Hospital
  - Saint Joseph, Michigan, Forente stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forente stater, 49085
    - Oncology Care Associates PLLC
  - Saint Joseph, Michigan, Forente stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Southfield, Michigan, Forente stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forente stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Wyoming, Michigan, Forente stater, 49519
    - University of Michigan Health - West
- Minnesota
  - Alexandria, Minnesota, Forente stater, 56308
    - Medini, Eitan MD (UIA Investigator)
  - Bemidji, Minnesota, Forente stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forente stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forente stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Etzell, Paul S MD (UIA Investigator)
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Swenson, Wade II, MD (UIA Investigator)
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forente stater, 55350
    - Hutchinson Area Health Care
  - Litchfield, Minnesota, Forente stater, 55355
    - Meeker County Memorial Hospital
  - Mankato, Minnesota, Forente stater, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forente stater, 55455
    - University of Minnesota/Masonic Cancer Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Virginia Piper Cancer Institute
  - Montevideo, Minnesota, Forente stater, 56265
    - Chippewa County - Montevideo Hospital
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forente stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forente stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - Saint Joseph's Hospital - Healtheast
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Woodbury, Minnesota, Forente stater, 55125
    - Woodwinds Health Campus
- Mississippi
  - Hattiesburg, Mississippi, Forente stater, 39401
    - Hattiesburg Clinic - Hematology/Oncology Clinic
  - Hattiesburg, Mississippi, Forente stater, 39402
    - Hematology and Oncology Clinic
  - Jackson, Mississippi, Forente stater, 39216
    - University of Mississippi Medical Center
  - Jackson, Mississippi, Forente stater, 39202
    - Jackson Oncology Associates PLLC
  - Keesler Air Force Base, Mississippi, Forente stater, 39534
    - Keesler Medical Center
  - Pascagoula, Mississippi, Forente stater, 39581
    - Singing River Hospital
- Missouri
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63701
    - Southeast Missouri Hospital
  - Chesterfield, Missouri, Forente stater, 63017
    - Saint Luke's Hospital
  - Columbia, Missouri, Forente stater, 65201
    - Missouri Cancer Associates
  - Columbia, Missouri, Forente stater, 65201
    - Veterans Administration
  - Columbia, Missouri, Forente stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Independence, Missouri, Forente stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forente stater, 65109
    - Capital Region Southwest Campus
  - Jefferson City, Missouri, Forente stater, 65101
    - Capital Region Medical Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forente stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forente stater, 64108
    - Truman Medical Centers
  - Kansas City, Missouri, Forente stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forente stater, 64114
    - Saint Joseph Health Center
  - Kansas City, Missouri, Forente stater, 64114
    - Radiation Oncology Practice Corporation South
  - Kansas City, Missouri, Forente stater, 64154
    - Radiation Oncology Practice Corporation - North
  - Lee's Summit, Missouri, Forente stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forente stater, 64068
    - Liberty Radiation Oncology Center
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forente stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forente stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forente stater, 63128
    - Mercy Hospital South
  - Saint Louis, Missouri, Forente stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - Saint Louis, Missouri, Forente stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Louis, Missouri, Forente stater, 63141
    - Saint Louis-Cape Girardeau CCOP
  - Saint Louis, Missouri, Forente stater, 63104
    - SSM Health Saint Louis University Hospital
  - Saint Louis, Missouri, Forente stater, 63141
    - Center for Cancer Care and Research
  - Springfield, Missouri, Forente stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forente stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
- Montana
  - Billings, Montana, Forente stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59102
    - Montana Cancer Consortium NCORP
  - Billings, Montana, Forente stater, 59101
    - Northern Rockies Radiation Oncology Center
  - Billings, Montana, Forente stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Billings, Montana, Forente stater, 59107
    - Deaconess Medical Center
  - Bozeman, Montana, Forente stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forente stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forente stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forente stater, 59405
    - Berdeaux, Donald MD (UIA Investigator)
  - Havre, Montana, Forente stater, 59501
    - Northern Montana Hospital
  - Helena, Montana, Forente stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Regional Medical Center
  - Kalispell, Montana, Forente stater, 59901
    - Glacier Oncology PLLC
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Medical Oncology
  - Missoula, Montana, Forente stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forente stater, 59804
    - Guardian Oncology and Center for Wellness
  - Missoula, Montana, Forente stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Grand Island, Nebraska, Forente stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forente stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forente stater, 68510
    - Nebraska Cancer Research Center
  - Omaha, Nebraska, Forente stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forente stater, 68198
    - University Of Nebraska Medical Center
  - Omaha, Nebraska, Forente stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forente stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forente stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forente stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forente stater, 68106
    - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forente stater, 68106
    - Cancer Alliance of Nebraska
  - Papillion, Nebraska, Forente stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forente stater, 89703
    - Carson-Tahoe Specialty Medical Center
  - Las Vegas, Nevada, Forente stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forente stater, 89169
    - Nevada Cancer Research Foundation NCORP
  - Reno, Nevada, Forente stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forente stater, 89503
    - Saint Mary's Regional Medical Center
- New Hampshire
  - Concord, New Hampshire, Forente stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Exeter, New Hampshire, Forente stater, 03833
    - Exeter Hospital
  - Keene, New Hampshire, Forente stater, 03431
    - Cheshire Medical Center-Dartmouth-Hitchcock Keene
  - Laconia, New Hampshire, Forente stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
  - Lebanon, New Hampshire, Forente stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Forente stater, 03103
    - Solinsky Center for Cancer Care
  - Manchester, New Hampshire, Forente stater, 03103
    - Elliot Hospital
  - Nashua, New Hampshire, Forente stater, 03060
    - Saint Joseph Hospital
  - Nashua, New Hampshire, Forente stater, 03060
    - Foundation Medical Partners
  - Portsmouth, New Hampshire, Forente stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Brick, New Jersey, Forente stater, 08724
    - Ocean University Medical Center
  - Camden, New Jersey, Forente stater, 08103
    - Cooper Hospital University Medical Center
  - Edison, New Jersey, Forente stater, 08818
    - John F Kennedy Medical Center
  - Englewood, New Jersey, Forente stater, 07631
    - Englewood Hospital and Medical Center
  - Flemington, New Jersey, Forente stater, 08822
    - Hunterdon Medical Center
  - Freehold, New Jersey, Forente stater, 07728
    - CentraState Medical Center
  - Hackensack, New Jersey, Forente stater, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Forente stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Livingston, New Jersey, Forente stater, 07039
    - Saint Barnabas Medical Center
  - Long Branch, New Jersey, Forente stater, 07740
    - Monmouth Medical Center
  - Montclair, New Jersey, Forente stater, 07042
    - Mountainside Hospital
  - Morristown, New Jersey, Forente stater, 07960
    - Morristown Medical Center
  - Mount Holly, New Jersey, Forente stater, 08060
    - Virtua Memorial
  - Neptune, New Jersey, Forente stater, 07753
    - Jersey Shore Medical Center
  - New Brunswick, New Jersey, Forente stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - New Brunswick, New Jersey, Forente stater, 08901
    - Saint Peter's University Hospital
  - Newark, New Jersey, Forente stater, 07101
    - Rutgers New Jersey Medical School
  - Newark, New Jersey, Forente stater, 07112
    - Newark Beth Israel Medical Center
  - Newark, New Jersey, Forente stater, 07102
    - Saint Michael's Medical Center
  - Paterson, New Jersey, Forente stater, 07503
    - Saint Joseph's Regional Medical Center
  - Pennington, New Jersey, Forente stater, 08534
    - Capital Health Medical Center-Hopewell
  - Phillipsburg, New Jersey, Forente stater, 08865
    - Saint Luke's Hospital-Warren Campus
  - Plainsboro, New Jersey, Forente stater, 08536
    - Penn Medicine Princeton Health
  - Pomona, New Jersey, Forente stater, 08240
    - AtlantiCare Regional Medical Center -Main Campus
  - Red Bank, New Jersey, Forente stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Ridgewood, New Jersey, Forente stater, 07450
    - Valley Hospital
  - Somers Point, New Jersey, Forente stater, 08244
    - Shore Memorial Hospital
  - Somerville, New Jersey, Forente stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Sparta, New Jersey, Forente stater, 07871
    - Sparta Cancer Treatment Center
  - Summit, New Jersey, Forente stater, 07902
    - Overlook Hospital
  - Toms River, New Jersey, Forente stater, 08755
    - Community Medical Center
  - Vineland, New Jersey, Forente stater, 08360
    - Inspira Medical Center Vineland
  - Voorhees, New Jersey, Forente stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forente stater, 87102
    - Lovelace Medical Center-Downtown
  - Albuquerque, New Mexico, Forente stater, 87106
    - Hematology Oncology Associates
  - Albuquerque, New Mexico, Forente stater, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Forente stater, 88011
    - Memorial Medical Center - Las Cruces
  - San Juan, New Mexico, Forente stater, 87401
    - San Juan Regional Medical Center
  - Santa Fe, New Mexico, Forente stater, 87505
    - Christus Saint Vincent Regional Cancer Center
- New York
  - Albany, New York, Forente stater, 12206
    - New York Oncology Hematology PC - Albany
  - Albany, New York, Forente stater, 12208
    - New York Oncology Hematology PC - Albany Medical Center
  - Amsterdam, New York, Forente stater, 12010
    - New York Oncology Hematology PC - Amsterdam
  - Bronx, New York, Forente stater, 10467
    - Montefiore Medical Center - Moses Campus
  - Bronx, New York, Forente stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Bronx, New York, Forente stater, 10466
    - Montefiore Medical Center-Wakefield Campus
  - Bronx, New York, Forente stater, 10451
    - Lincoln Medical and Mental Health Center
  - Bronx, New York, Forente stater, 10456
    - Bronx-Lebanon Hospital Center
  - Brooklyn, New York, Forente stater, 11235
    - Coney Island Hospital
  - Buffalo, New York, Forente stater, 14263
    - Roswell Park Cancer Institute
  - Clifton Park, New York, Forente stater, 12065
    - New York Oncology Hematology PC - Clifton Park
  - Clifton Springs, New York, Forente stater, 14432
    - Finger Lakes Hematology and Oncology
  - Cooperstown, New York, Forente stater, 13326
    - Mary Imogene Bassett Hospital
  - East Syracuse, New York, Forente stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forente stater, 12801
    - Glens Falls Hospital
  - Glens Falls, New York, Forente stater, 12801
    - Adirondack Cancer Center
  - Harris, New York, Forente stater, 12742
    - Catskill Regional Medical Center
  - Hudson, New York, Forente stater, 12534
    - New York Oncology Hematology PC-Hudson
  - Jamaica, New York, Forente stater, 11432
    - Queens Hospital Center
  - Kingston, New York, Forente stater, 12401
    - Benedictine Hospital
  - Lake Success, New York, Forente stater, 11042
    - Northwell Health NCORP
  - Lake Success, New York, Forente stater, 11042
    - Northwell Health/Center for Advanced Medicine
  - Manhasset, New York, Forente stater, 11030
    - North Shore University Hospital
  - Middletown, New York, Forente stater, 10940
    - Garnet Health Medical Center
  - Mineola, New York, Forente stater, 11501
    - NYU Winthrop Hospital
  - New Hyde Park, New York, Forente stater, 11040
    - Long Island Jewish Medical Center
  - New York, New York, Forente stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forente stater, 10019
    - Mount Sinai West
  - New York, New York, Forente stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forente stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forente stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forente stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - New York, New York, Forente stater, 10035
    - Ralph Lauren Center for Cancer Care and Prevention
  - New York, New York, Forente stater, 10003
    - Mount Sinai Union Square
  - Nyack, New York, Forente stater, 10960
    - Nyack Hospital
  - Plattsburgh, New York, Forente stater, 12901
    - Champlain Valley Physicians Hospital Medical Center
  - Poughkeepsie, New York, Forente stater, 12601
    - Vassar Brothers Medical Center
  - Poughkeepsie, New York, Forente stater, 12601
    - MidHudson Regional Hospital of Westchester Medical Center
  - Poughkeepsie, New York, Forente stater, 12601
    - Hudson Valley Hematology Oncology Associates
  - Poughkeepsie, New York, Forente stater, 12601
    - The Dyson Center for Cancer Care
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - Rochester, New York, Forente stater, 14620
    - Highland Hospital
  - Rochester, New York, Forente stater, 14623
    - Interlakes Foundation Inc-Rochester
  - Rochester, New York, Forente stater, 14621
    - Rochester General Hospital
  - Staten Island, New York, Forente stater, 10305
    - Staten Island University Hospital
  - Staten Island, New York, Forente stater, 10310
    - Richmond University Medical Center
  - Stony Brook, New York, Forente stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forente stater, 13210
    - State University of New York Upstate Medical University
  - Troy, New York, Forente stater, 12180
    - New York Oncology Hematology PC - Troy
  - Utica, New York, Forente stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheboro, North Carolina, Forente stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forente stater, 28801
    - Mission Hospital
  - Asheville, North Carolina, Forente stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Cary, North Carolina, Forente stater, 27518
    - Waverly Hematology Oncology
  - Chapel Hill, North Carolina, Forente stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forente stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forente stater, 28204
    - Novant Health Presbyterian Medical Center
  - Concord, North Carolina, Forente stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forente stater, 27710
    - Duke University Medical Center
  - Eden, North Carolina, Forente stater, 27288
    - Moorehead Memorial Hospital
  - Fayetteville, North Carolina, Forente stater, 28304
    - Cape Fear Valley Health System
  - Gastonia, North Carolina, Forente stater, 28054
    - CaroMont Regional Medical Center
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Memorial Hospital
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Radiation Oncology
  - Greensboro, North Carolina, Forente stater, 27403
    - Cone Health Cancer Center
  - Greenville, North Carolina, Forente stater, 27834
    - East Carolina University
  - Henderson, North Carolina, Forente stater, 27536
    - Maria Parham Hospital
  - Hendersonville, North Carolina, Forente stater, 28792
    - AdventHealth Hendersonville
  - High Point, North Carolina, Forente stater, 27262
    - High Point Regional Hospital
  - Kinston, North Carolina, Forente stater, 28501
    - Vidant Oncology-Kinston
  - Lumberton, North Carolina, Forente stater, 28358
    - Southeastern Regional Medical Center
  - Oxford, North Carolina, Forente stater, 27565
    - Granville Medical Center
  - Pinehurst, North Carolina, Forente stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forente stater, 27607
    - UNC Rex Healthcare
  - Raleigh, North Carolina, Forente stater, 27609
    - Duke Raleigh Hospital
  - Reidsville, North Carolina, Forente stater, 27320
    - Annie Penn Memorial Hospital
  - Roxboro, North Carolina, Forente stater, 27573
    - Person Memorial Hospital
  - Rutherfordton, North Carolina, Forente stater, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, Forente stater, 28677
    - Iredell Memorial Hospital
  - Washington, North Carolina, Forente stater, 27889
    - Marion L Shepard Cancer Center at Vidant Beaufort Hospital
  - Wilmington, North Carolina, Forente stater, 28401
    - Novant Health New Hanover Regional Medical Center
  - Wilson, North Carolina, Forente stater, 27893
    - Wilson Medical Center
  - Winston-Salem, North Carolina, Forente stater, 27157
    - Wake Forest University Health Sciences
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forente stater, 27104
    - Southeast Clinical Oncology Research Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forente stater, 58501
    - Sanford Bismarck Medical Center
  - Bismarck, North Dakota, Forente stater, 58501
    - Mid Dakota Clinic
  - Bismarck, North Dakota, Forente stater, 58501
    - Saint Alexius Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Clinic North-Fargo
  - Grand Forks, North Dakota, Forente stater, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Forente stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forente stater, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Forente stater, 44304
    - Summa Health System - Akron Campus
  - Barberton, Ohio, Forente stater, 44203
    - Summa Health System - Barberton Campus
  - Bellefontaine, Ohio, Forente stater, 43311
    - Mary Rutan Hospital
  - Bowling Green, Ohio, Forente stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Bryan, Ohio, Forente stater, 43506
    - Community Hospital and Wellness Centers
  - Canton, Ohio, Forente stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forente stater, 44710
    - Aultman Health Foundation
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forente stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forente stater, 45219
    - University of Cincinnati Cancer Center-UC Medical Center
  - Cincinnati, Ohio, Forente stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forente stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cleveland, Ohio, Forente stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forente stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forente stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forente stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Clyde, Ohio, Forente stater, 43410
    - North Coast Cancer Care-Clyde
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forente stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forente stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forente stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forente stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forente stater, 45459
    - Dayton NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45428
    - Dayton Veterans Affairs Medical Center
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forente stater, 44035
    - Hematology Oncology Center Incorporated
  - Findlay, Ohio, Forente stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forente stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Fremont, Ohio, Forente stater, 43420
    - Fremont Memorial Hospital
  - Greenville, Ohio, Forente stater, 45331
    - Wayne Hospital
  - Independence, Ohio, Forente stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kenton, Ohio, Forente stater, 43326
    - Cole, Sharon, K. M.D. (UIA Investigator)
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Lima, Ohio, Forente stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forente stater, 45804
    - Lima Memorial Hospital
  - Mansfield, Ohio, Forente stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Maumee, Ohio, Forente stater, 43537
    - Saint Luke's Hospital
  - Mayfield Heights, Ohio, Forente stater, 44124
    - Hillcrest Hospital Cancer Center
  - Newark, Ohio, Forente stater, 43055
    - Licking Memorial Hospital
  - Norwalk, Ohio, Forente stater, 44857
    - Fisher-Titus Medical Center
  - Oregon, Ohio, Forente stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forente stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Salem, Ohio, Forente stater, 44460
    - UH Seidman Cancer Center at Salem Regional Medical Center
  - Sandusky, Ohio, Forente stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forente stater, 44870
    - Firelands Regional Medical Center
  - Springfield, Ohio, Forente stater, 45505
    - Springfield Regional Medical Center
  - Sylvania, Ohio, Forente stater, 43560
    - ProMedica Flower Hospital
  - Tiffin, Ohio, Forente stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forente stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Toledo, Ohio, Forente stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forente stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forente stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forente stater, 43623
    - Stark, Michael, Edward. M.D. (UIA Investigator)
  - Troy, Ohio, Forente stater, 45373
    - Upper Valley Medical Center
  - Warren, Ohio, Forente stater, 44484
    - Saint Joseph Warren Hospital
  - Wauseon, Ohio, Forente stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Wilmington, Ohio, Forente stater, 45177
    - Clinton Memorial Hospital
  - Wooster, Ohio, Forente stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wooster, Ohio, Forente stater, 44691
    - Cancer Treatment Center
  - Wright-Patterson Air Force Base, Ohio, Forente stater, 45433
    - Wright-Patterson Medical Center
  - Xenia, Ohio, Forente stater, 45385
    - Greene Memorial Hospital
  - Youngstown, Ohio, Forente stater, 44501
    - Tod Children's Hospital - Forum Health
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forente stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forente stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Mercy Hospital Oklahoma City
  - Oklahoma City, Oklahoma, Forente stater, 73120
    - Cancer Care Associates
  - Tulsa, Oklahoma, Forente stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
  - Tulsa, Oklahoma, Forente stater, 74104
    - Saint John Medical Center
- Oregon
  - Bend, Oregon, Forente stater, 97701
    - Saint Charles Health System
  - Bend, Oregon, Forente stater, 97701
    - Bend Memorial Clinic
  - Coos Bay, Oregon, Forente stater, 97420
    - Bay Area Hospital
  - Grants Pass, Oregon, Forente stater, 97527
    - Three Rivers Community Hospital
  - Gresham, Oregon, Forente stater, 97030
    - Legacy Mount Hood Medical Center
  - Klamath Falls, Oregon, Forente stater, 97601
    - Sky Lakes Medical Center - Cancer Treatment Center
  - Medford, Oregon, Forente stater, 97504
    - Asante Health System
  - Medford, Oregon, Forente stater, 97504
    - Providence Medford Medical Center
  - Medford, Oregon, Forente stater, 97504
    - Rogue Valley Medical Center
  - Milwaukie, Oregon, Forente stater, 97222
    - Providence Milwaukie Hospital
  - Portland, Oregon, Forente stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forente stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forente stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forente stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Kaiser Permanente Northwest
  - Portland, Oregon, Forente stater, 97227
    - Legacy Emanuel Hospital and Health Center
  - Portland, Oregon, Forente stater, 97216
    - Adventist Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Compass Oncology Rose Quarter
  - Salem, Oregon, Forente stater, 97301
    - Salem Hospital
  - Tualatin, Oregon, Forente stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Abington, Pennsylvania, Forente stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Allentown, Pennsylvania, Forente stater, 18102
    - Sacred Heart Hospital
  - Bethlehem, Pennsylvania, Forente stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forente stater, 19010
    - Bryn Mawr Hospital
  - Danville, Pennsylvania, Forente stater, 17822
    - Geisinger Medical Center
  - Darby, Pennsylvania, Forente stater, 19023-1291
    - Mercy Fitzgerald Hospital
  - Doylestown, Pennsylvania, Forente stater, 18901
    - Doylestown Hospital
  - Drexel Hill, Pennsylvania, Forente stater, 19026
    - Delaware County Memorial Hospital
  - DuBois, Pennsylvania, Forente stater, 15801
    - Oncology Hematology Associates of Northern Pennsylvania
  - East Stroudsburg, Pennsylvania, Forente stater, 18301
    - Pocono Medical Center
  - Easton, Pennsylvania, Forente stater, 18042
    - Easton Hospital
  - Ephrata, Pennsylvania, Forente stater, 17522
    - Ephrata Cancer Center
  - Erie, Pennsylvania, Forente stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Erie, Pennsylvania, Forente stater, 16544
    - Saint Vincent Hospital
  - Harrisburg, Pennsylvania, Forente stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forente stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forente stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Johnstown, Pennsylvania, Forente stater, 15905-4398
    - Conemaugh Memorial Medical Center
  - Lancaster, Pennsylvania, Forente stater, 17602
    - Lancaster General Hospital
  - Langhorne, Pennsylvania, Forente stater, 19047
    - Saint Mary Medical and Regional Cancer Center
  - Lewistown, Pennsylvania, Forente stater, 17044
    - Lewistown Hospital
  - Meadowbrook, Pennsylvania, Forente stater, 19046
    - Holy Redeemer Hospital and Medical Center
  - Media, Pennsylvania, Forente stater, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Forente stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forente stater, 19141
    - Einstein Medical Center Philadelphia
  - Philadelphia, Pennsylvania, Forente stater, 19107
    - Pennsylvania Hospital
  - Philadelphia, Pennsylvania, Forente stater, 19102
    - Drexel University School of Medicine
  - Philadelphia, Pennsylvania, Forente stater, 19118
    - Chestnut Hill Health System
  - Phoenixville, Pennsylvania, Forente stater, 19460
    - Phoenixville Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forente stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pottstown, Pennsylvania, Forente stater, 19464
    - Pottstown Hospital
  - Reading, Pennsylvania, Forente stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forente stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forente stater, 18510
    - Scranton Hematology Oncology
  - Scranton, Pennsylvania, Forente stater, 18501
    - Mercy Hospital
  - Scranton, Pennsylvania, Forente stater, 18508
    - Hematology and Oncology Associates of North East Pennsylvania
  - Sellersville, Pennsylvania, Forente stater, 18960
    - Grand View Hospital
  - State College, Pennsylvania, Forente stater, 16801
    - Geisinger Medical Group
  - State College, Pennsylvania, Forente stater, 16803
    - Mount Nittany Medical Center
  - Upland, Pennsylvania, Forente stater, 19013
    - Associates In Hematology Oncology PC-Upland
  - West Chester, Pennsylvania, Forente stater, 19380
    - Chester County Hospital
  - West Grove, Pennsylvania, Forente stater, 19390
    - Jennersville Regional Hospital
  - West Reading, Pennsylvania, Forente stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forente stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forente stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Lankenau Medical Center
  - Wynnewood, Pennsylvania, Forente stater, 19096
    - Main Line Health NCORP
  - York, Pennsylvania, Forente stater, 17403
    - WellSpan Health-York Hospital
- Rhode Island
  - Cranston, Rhode Island, Forente stater, 02920
    - Hematology and Oncology Associates of Rhode Island Inc
  - Pawtucket, Rhode Island, Forente stater, 02860
    - Memorial Hospital of Rhode Island
  - Providence, Rhode Island, Forente stater, 02903
    - Rhode Island Hospital
  - Providence, Rhode Island, Forente stater, 02905
    - Women and Infants Hospital
  - Providence, Rhode Island, Forente stater, 02906
    - Miriam Hospital
  - Providence, Rhode Island, Forente stater, 02908
    - Roger Williams Medical Center
  - Warwick, Rhode Island, Forente stater, 02886
    - Kent Hospital
- South Carolina
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Hospital
  - Beaufort, South Carolina, Forente stater, 29902
    - Beaufort Memorial Hospital
  - Charleston, South Carolina, Forente stater, 29425
    - Medical University of South Carolina
  - Charleston, South Carolina, Forente stater, 29401
    - Roper Hospital
  - Columbia, South Carolina, Forente stater, 29210
    - South Carolina Oncology Associates PA
  - Florence, South Carolina, Forente stater, 29506
    - McLeod Regional Medical Center
  - Georgetown, South Carolina, Forente stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, Forente stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forente stater, 29601
    - Saint Francis Hospital
  - Spartanburg, South Carolina, Forente stater, 29303
    - Spartanburg Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forente stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forente stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Cancer Center Oncology Clinic
  - Sioux Falls, South Dakota, Forente stater, 57105
    - Medical X-Ray Center
  - Sioux Falls, South Dakota, Forente stater, 57117-5045
    - Avera McKennan Hospital and University Health Center
- Tennessee
  - Bristol, Tennessee, Forente stater, 37620
    - Wellmont Medical Associates Oncology and Hematology-Bristol
  - Chattanooga, Tennessee, Forente stater, 37403
    - Erlanger Medical Center
  - Cookeville, Tennessee, Forente stater, 38501
    - Cookeville Regional Medical Center
  - Franklin, Tennessee, Forente stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Germantown, Tennessee, Forente stater, 38138
    - Jones Clinic
  - Jackson, Tennessee, Forente stater, 38301
    - Jackson-Madison County General Hospital
  - Jackson, Tennessee, Forente stater, 38301
    - The Jackson Clinic PA
  - Kingsport, Tennessee, Forente stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forente stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forente stater, 37920
    - University of Tennessee - Knoxville
  - Knoxville, Tennessee, Forente stater, 37909
    - Tennessee Cancer Specialists-Dowell Springs
  - Knoxville, Tennessee, Forente stater, 37920
    - East Tennessee Baptist Hospital-Mercy Health Partners
  - Memphis, Tennessee, Forente stater, 38163
    - University of Tennessee Health Science Center
  - Nashville, Tennessee, Forente stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forente stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Nashville, Tennessee, Forente stater, 37208
    - Meharry Medical College
  - Nashville, Tennessee, Forente stater, 37203
    - Nashville Oncology Associates PC
  - Nashville, Tennessee, Forente stater, 37205
    - Saint Thomas Hospital
  - Nashville, Tennessee, Forente stater, 37203
    - Nashville Breast Center
  - Nashville, Tennessee, Forente stater, 37203
    - Tennessee Oncology PLLC- Centennial Medical Center
  - Nashville, Tennessee, Forente stater, 37236
    - Saint Thomas Midtown Hospital
  - Powell, Tennessee, Forente stater, 37849
    - Saint Mary's North Cancer Center
- Texas
  - Amarillo, Texas, Forente stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Austin, Texas, Forente stater, 78701
    - Dell Seton Medical Center at The University of Texas
  - Austin, Texas, Forente stater, 78705
    - Texas Oncology-Austin Midtown
  - Austin, Texas, Forente stater, 78731
    - Texas Oncology - Central Austin Cancer Center
  - Austin, Texas, Forente stater, 78745
    - Texas Oncology - South Austin Cancer Center
  - Austin, Texas, Forente stater, 78758
    - Texas Oncology-Austin North
  - Austin, Texas, Forente stater, 78759
    - Texas Oncology Seton Northwest
  - Bryan, Texas, Forente stater, 77802
    - Saint Joseph Regional Cancer Center
  - Burleson, Texas, Forente stater, 76115
    - The Center for Cancer and Blood Disorders-Burleson
  - Cedar Park, Texas, Forente stater, 78613
    - Texas Oncology-Cedar Park
  - Cleburne, Texas, Forente stater, 76033
    - The Center for Cancer and Blood Disorders-Cleburne
  - Dallas, Texas, Forente stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forente stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forente stater, 75230
    - Medical City Dallas Hospital
  - Dallas, Texas, Forente stater, 75390
    - Clements University Hospital
  - Duncanville, Texas, Forente stater, 75137
    - Dallas Oncology Consultants PA
  - El Paso, Texas, Forente stater, 79902
    - The Center for Integrative Cancer Medicine
  - Fort Sam Houston, Texas, Forente stater, 78234
    - Brooke Army Medical Center
  - Fort Worth, Texas, Forente stater, 76104
    - The Center for Cancer and Blood Disorders-Fort Worth
  - Houston, Texas, Forente stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forente stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forente stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forente stater, 77030
    - Ben Taub General Hospital
  - Lackland Air Force Base, Texas, Forente stater, 78236
    - Wilford Hall Medical Center
  - Laredo, Texas, Forente stater, 78041
    - Doctor's Hospital of Laredo
  - Lubbock, Texas, Forente stater, 79410
    - Covenant Medical Center-Lakeside
  - Lubbock, Texas, Forente stater, 79430
    - Texas Tech University Health Sciences Center-Lubbock
  - Mineral Wells, Texas, Forente stater, 76067
    - The Center for Cancer and Blood Disorders-Mineral Wells
  - Round Rock, Texas, Forente stater, 78665
    - Texas Oncology-Seton Williamson
  - Round Rock, Texas, Forente stater, 78681
    - Texas Oncology - Round Rock Cancer Center
  - San Antonio, Texas, Forente stater, 78229
    - University Hospital
  - San Antonio, Texas, Forente stater, 78229
    - University of Texas Health Science Center at San Antonio
  - San Antonio, Texas, Forente stater, 78229
    - Cancer Therapy and Research Center at The UT Health Science Center at San Antonio
  - San Marcos, Texas, Forente stater, 78666
    - Texas Oncology- San Marcos
  - Temple, Texas, Forente stater, 76508
    - Scott and White Memorial Hospital
  - Weatherford, Texas, Forente stater, 76086
    - The Center for Cancer and Blood Disorders-Weatherford
- Utah
  - American Fork, Utah, Forente stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forente stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forente stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forente stater, 84107
    - Intermountain Medical Center
  - Murray, Utah, Forente stater, 84107
    - Cottonwood Hospital Medical Center
  - Ogden, Utah, Forente stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forente stater, 84604
    - Utah Valley Regional Medical Center
  - Saint George, Utah, Forente stater, 84770
    - Saint George Regional Medical Center
  - Salt Lake City, Utah, Forente stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forente stater, 84143
    - LDS Hospital
  - Salt Lake City, Utah, Forente stater, 84103
    - Intermountain Health Care
- Vermont
  - Bennington, Vermont, Forente stater, 05201
    - Southwestern Vermont Medical Center
  - Burlington, Vermont, Forente stater, 05405
    - University of Vermont and State Agricultural College
  - Rutland, Vermont, Forente stater, 05701
    - Rutland Regional Medical Center
  - Windsor, Vermont, Forente stater, 05089
    - Mount Ascutney Hospital and Health Center
- Virginia
  - Charlottesville, Virginia, Forente stater, 22908
    - University of Virginia Cancer Center
  - Charlottesville, Virginia, Forente stater, 22901
    - Sentara Martha Jefferson Hospital
  - Danville, Virginia, Forente stater, 24541
    - Danville Regional Medical Center
  - Falls Church, Virginia, Forente stater, 22042
    - Inova Fairfax Hospital
  - Fredericksburg, Virginia, Forente stater, 22401
    - Fredericksburg Oncology Inc
  - Gloucester, Virginia, Forente stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Hampton, Virginia, Forente stater, 23666
    - Virginia Oncology Associates-Hampton
  - Lynchburg, Virginia, Forente stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - Newport News, Virginia, Forente stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Newport News, Virginia, Forente stater, 23606
    - Sentara Port Warwick
  - Norfolk, Virginia, Forente stater, 23507
    - Eastern Virginia Medical School
  - Norton, Virginia, Forente stater, 24273
    - Southwest VA Regional Cancer Center
  - Richmond, Virginia, Forente stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forente stater, 23229
    - Virginia Cancer Institute
  - Williamsburg, Virginia, Forente stater, 23185
    - Peninsula Cancer Institute-Williamsburg
- Washington
  - Auburn, Washington, Forente stater, 98001
    - MultiCare Auburn Medical Center
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forente stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Centralia, Washington, Forente stater, 98531
    - Providence Regional Cancer System-Centralia
  - Federal Way, Washington, Forente stater, 98003
    - Saint Francis Hospital
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Forente stater, 98033
    - EvergreenHealth Medical Center
  - Lakewood, Washington, Forente stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forente stater, 98632
    - PeaceHealth Saint John Medical Center
  - Olympia, Washington, Forente stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Olympia, Washington, Forente stater, 98507
    - Capital Medical Center
  - Port Angeles, Washington, Forente stater, 98362
    - Olympic Medical Center
  - Poulsbo, Washington, Forente stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forente stater, 98372
    - MultiCare Good Samaritan Hospital
  - Renton, Washington, Forente stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forente stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forente stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forente stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forente stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forente stater, 98104
    - Pacific Medical Center-First Hill
  - Spokane, Washington, Forente stater, 99204
    - Providence Sacred Heart Medical Center and Children's Hospital
  - Spokane, Washington, Forente stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forente stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forente stater, 99220
    - Rockwood Clinic
  - Spokane, Washington, Forente stater, 99208
    - Providence Holy Family Hospital
  - Tacoma, Washington, Forente stater, 98431
    - Madigan Army Medical Center
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Allenmore Hospital
  - Tacoma, Washington, Forente stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Tacoma, Washington, Forente stater, 98405
    - Saint Joseph Medical Center
  - Vancouver, Washington, Forente stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forente stater, 98684
    - Compass Oncology Vancouver
  - Yakima, Washington, Forente stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yakima, Washington, Forente stater, 98902
    - Cancer Institutes of Washington PLLC
- West Virginia
  - Bridgeport, West Virginia, Forente stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forente stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forente stater, 25701
    - Edwards Comprehensive Cancer Center
  - Huntington, West Virginia, Forente stater, 25702
    - Saint Mary's Medical Center
  - Huntington, West Virginia, Forente stater, 25701
    - Marshall University Medical Center
  - Morgantown, West Virginia, Forente stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forente stater, 26101
    - Camden Clark Medical Center
  - Princeton, West Virginia, Forente stater, 24740
    - Princeton Community Hospital
  - Wheeling, West Virginia, Forente stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Antigo, Wisconsin, Forente stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forente stater, 54911
    - ThedaCare Regional Cancer Center
  - Appleton, Wisconsin, Forente stater, 54911
    - Fox Valley Surgical Associates Limited
  - Burlington, Wisconsin, Forente stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forente stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forente stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond Du Lac, Wisconsin, Forente stater, 54935
    - Saint Agnes Hospital/Agnesian Cancer Center
  - Franklin, Wisconsin, Forente stater, 53132
    - Aurora Cancer Care-Franklin
  - Glendale, Wisconsin, Forente stater, 53212
    - Aurora Cancer Care-Glendale
  - Green Bay, Wisconsin, Forente stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forente stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forente stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forente stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forente stater, 53548
    - Mercyhealth Hospital and Cancer Center - Janesville
  - Johnson Creek, Wisconsin, Forente stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forente stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forente stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forente stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Madison, Wisconsin, Forente stater, 53717
    - Dean Hematology and Oncology Clinic
  - Madison, Wisconsin, Forente stater, 53792
    - University of Wisconsin Carbone Cancer Center
  - Manitowoc, Wisconsin, Forente stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forente stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forente stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center-Marshfield
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Medical Center
  - Mequon, Wisconsin, Forente stater, 53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee, Wisconsin, Forente stater, 53226
    - Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forente stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forente stater, 53210
    - Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
  - Milwaukee, Wisconsin, Forente stater, 53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Minocqua, Wisconsin, Forente stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Oconomowoc, Wisconsin, Forente stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forente stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forente stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forente stater, 53405
    - Ascension All Saints Hospital
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forente stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forente stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Ascension Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forente stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Summit, Wisconsin, Forente stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forente stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forente stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forente stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forente stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forente stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forente stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forente stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Casper, Wyoming, Forente stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forente stater, 82801
    - Welch Cancer Center
Irland
- - Cork, Irland
    - Cork University Hospital
  - Dublin, Irland, 8
    - Saint James Hospital
  - Letterkenny, Irland, Co Donegal
    - Letterkenny General Hospital
- Co Cork
  - Cork, Co Cork, Irland
    - Bon Secours Hospital
  - Cork, Co Cork, Irland
    - South Infirmary Victoria Hospital
- Co Dublin
  - Dublin, Co Dublin, Irland, 24
    - Tallaght University Hospital
  - Dublin, Co Dublin, Irland, 4
    - Saint Vincent's University Hospital
  - Dublin, Co Dublin, Irland, 7
    - Mater Misericordiae University Hospital
  - Dublin, Co Dublin, Irland, 7
    - Mater Private Hospital
  - Dublin, Co Dublin, Irland, 9
    - Beaumont Hospital
  - Merrion, Co Dublin, Irland, 4
    - Saint Vincent's Private Hospital
- Co Galway
  - Galway, Co Galway, Irland
    - University College Hospital Galway
- Co Limerick
  - Limerick, Co Limerick, Irland, 9
    - Mid-Western Regional Hospital
- Co Sligo
  - Sligo, Co Sligo, Irland
    - Sligo University Hospital
- Co Waterford
  - Waterford, Co Waterford, Irland, 9
    - University Hospital Waterford
New Zealand
- - Hamilton, New Zealand, 3204
    - Waikato Hospital
  - Wellington, New Zealand, 6021
    - Wellington Hospital
- Auckland
  - Grafton, Auckland, New Zealand, 1023
    - Auckland City Hospital
Peru
- - Lima, Peru, Lima 34
    - Instituto Nacional de Enfermedades Neoplasicas
Puerto Rico
- - San Juan, Puerto Rico, 00936
    - San Juan City Hospital
Storbritannia
- Northern Ireland
  - Belfast, Northern Ireland, Storbritannia, BT9 7AB
    - Belfast City Hospital

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

18 år til 75 år (Voksen, Eldre voksen)

Tar imot friske frivillige

Nei

Beskrivelse

Inklusjonskriterier:

Pasienter med operabelt histologisk bekreftet adenokarsinom i det kvinnelige brystet som har fullført primær kirurgisk behandling og oppfyller følgende kriterier:
- ER og/eller progesteronreseptor (PR)-positiv: Østrogen- og/eller progesteronreseptorpositiv sykdom (som definert av lokalt patologilaboratorium)
- Negative aksillære noder: Som vurdert av en vaktpostlymfeknutebiopsi, en aksillær disseksjon, eller begge deler, og som definert av den sjette utgaven av American Joint Committee on Cancer (AJCC) iscenesettelseskriterier
- Tumorstørrelse 1,1-5,0 cm (eller 5 mm-1,0 cm pluss ugunstige histologiske egenskaper):
  - Ugunstige egenskaper definert som middels eller dårlig kjernefysisk og/eller histologisk karakter, eller lymfovaskulær invasjon
  - MERK: Definisjon av svulststørrelse: Svulststørrelsen som brukes for å bestemme kvalifisering er den patologiske svulststørrelsen, som vanligvis bestemmes av størrelsen på svulsten målt ved inspeksjon av bruttoprøven; hvis svulstens størrelse måles mikroskopisk og svulsten inkluderer duktalt karsinom in situ, bør målingen kun inkludere den invasive komponenten av svulsten
- Svulsten må være human epidermal vekstfaktor reseptor 2 (Her2)/neu negativ ved enten fluorescerende in-situ hybridisering (FISH) eller immunhistokjemi (f.eks. 0 eller 1+ av DAKO Herceptest)
Pasienten og legen må være enige om å starte standard kjemoterapi og hormonbehandling som adjuvant terapi
En vevsprøve fra den primære brystkreften er lokalisert og er klar til å sendes til det aktuelle laboratoriet etter at samtykke er innhentet og innen 3 dager etter forhåndsregistrering; MERK: For bestemmelse av oncotype-residivpoeng, må vev sendes til Genomic Health; hvis Oncotype DX-resurrence-score tidligere ble utført av Genomic Health (før forhåndsregistrering), må vev sendes til Eastern Cooperative Oncology Group (ECOG)-American College of Radiology Imaging Network (ACRIN) Central Biorepository and Pathology Facility ved randomisering
Leukocyttantall >= 3500/mm^3
Blodplater >= 100 000/mm^3
Serumkreatinin =< 1,5 mg/dL
Serumaspartattransaminase (ASAT) som er =< 3 ganger de øvre institusjonelle grensene for normalen
Pasienter må være sykdomsfrie for tidligere invasive maligniteter i >= 5 år med unntak av kurativt behandlet basalcelle- eller plateepitelkarsinom i huden eller karsinom in situ i livmorhalsen; pasienter med tidligere ipsilateral eller kontralateral invasiv brystkreft, eller med bilateral synkron kreft, er ikke kvalifisert; Pasienter med tidligere ipsilateralt eller kontralateralt duktalt in situ karsinom (DCIS) er ikke kvalifisert
Forutgående behandling
- Obligatoriske kriterier før operasjon:
  - Pasienten må forhåndsregistrere seg innen 84 dager fra den siste kirurgiske prosedyren som kreves for å behandle primærsvulsten adekvat (vær oppmerksom på at hvis marginene ikke er klare og en reseksjon må utføres etter forhåndsregistrering, men før randomisering, vil pasienten bli ansett for å være innenfor 84-dagersvinduet tillatt av protokollen og derfor kvalifisert)
  - Alle svulster bør fjernes enten ved mastektomi eller lokal eksisjon pluss en akseptabel aksillær prosedyre (dvs. vaktpostlymfeknutebiopsi, aksillær disseksjon eller begge deler); det må være tilstrekkelig (minst 1 mm hvis marginbredde er spesifisert) tumorfrie reseksjonsmarginer (for invasivt og duktalt karsinom in situ) for at pasientene skal være kvalifisert; Pasienter med lobulært karsinom in situ som involverer reseksjonsmarginene er kvalifisert
- Kriterier om: andre tidligere behandlinger:
  - Ingen tidligere kjemoterapi for denne maligniteten
  - Ingen tidligere strålebehandling for denne maligniteten; dette inkluderer ingen tidligere MammoSite Brachyterapi strålebehandling (RT)
  - Hormonell behandling: Pasienter som utvikler brystkreft mens de får en selektiv østrogenreseptormodulator (SERM; f.eks. tamoxifen, toremifen, raloxifen) eller en aromatasehemmer (f.eks. anastrazol, letrozol, exemestan) for brystkreftforebygging eller en SERM (f.eks. raloxifen for osteoporose) er ikke kvalifisert; pasienter kan imidlertid ha mottatt opptil 8 uker med en SERM- eller aromatasehemmer for denne maligniteten og fortsatt være kvalifisert for studiestart
Pasienter må ha en forventet levealder på minst 10 år
Pasienter med følgende medisinske tilstander bør ikke delta i studien:
- Kronisk obstruktiv lungesykdom som krever behandling
- Kronisk leversykdom (f.eks. skrumplever, kronisk aktiv hepatitt)
- Tidligere historie med en cerebrovaskulær ulykke
- Anamnese med kongestiv hjertesvikt eller annen hjertesykdom som vil representere en kontraindikasjon for bruk av et antracyklin (f.eks. doksorubicin eller epirubicin)
- Kronisk psykiatrisk tilstand eller annen tilstand som vil svekke overholdelse av behandlingsregimet
Kvinner må ikke være gravide eller ammende; alle kvinner i fertil alder må ha en blodprøve eller urinstudie innen 2 uker før forhåndsregistrering for å utelukke graviditet
- Kvinner i fertil alder må anbefales sterkt å bruke en akseptert og effektiv form for ikke-hormonell prevensjon (f. intrauterin enhet, kondomer, diafragma, abstinens)
Pasienter må ikke tidligere ha fått utført Oncotype DX-analysen, med unntak av pasienter som har fått analysen utført og har en residivscore på 11-25

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: Behandling
Tildeling: Randomisert
Intervensjonsmodell: Parallell tildeling
Masking: Ingen (Open Label)

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
Eksperimentell: Gruppe 1 (Oncotype DX-residivscore =< 10) Pasienter i denne gruppen får hormonbehandling med tamoxifen, anastrozol, letrozol eller exemestan PO i opptil 5 år. Noen pasienter fortsetter deretter å motta hormonbehandling i ytterligere 5 år.	Annen: Laboratoriebiomarkøranalyse Korrelative studier Annen: Livskvalitetsvurdering Hjelpestudier Andre navn: Livskvalitetsvurdering Legemiddel: Letrozol Gitt PO Andre navn: CGS 20267 Femara Fempro Legemiddel: Anastrozol Gitt PO Andre navn: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Legemiddel: Eksemestan Gitt PO Andre navn: Aromasin FCE-24304 Legemiddel: Tamoxifen Citrate Gitt PO Andre navn: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide Stråling: Strålebehandling Gjennomgå strålebehandling eller delvis brystbestråling Andre navn: Kreft Strålebehandling ENERGY_TYPE Bestråle Bestrålt Bestråling Stråling Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, stråling Energitype
Eksperimentell: Gruppe 2, arm I (eksperimentell) Pasienter får hormonbehandling som i gruppe 1 etter den behandlende legens skjønn.	Annen: Laboratoriebiomarkøranalyse Korrelative studier Annen: Livskvalitetsvurdering Hjelpestudier Andre navn: Livskvalitetsvurdering Legemiddel: Letrozol Gitt PO Andre navn: CGS 20267 Femara Fempro Legemiddel: Anastrozol Gitt PO Andre navn: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Legemiddel: Eksemestan Gitt PO Andre navn: Aromasin FCE-24304 Legemiddel: Tamoxifen Citrate Gitt PO Andre navn: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide
Aktiv komparator: Gruppe 2, arm II (standard) Pasienter får standard kombinasjonskjemoterapi etter den behandlende legens skjønn. Innen 4 uker etter siste dose med kjemoterapi får pasientene hormonbehandling som i gruppe 1 etter den behandlende legens skjønn.	Annen: Laboratoriebiomarkøranalyse Korrelative studier Annen: Livskvalitetsvurdering Hjelpestudier Andre navn: Livskvalitetsvurdering Legemiddel: Letrozol Gitt PO Andre navn: CGS 20267 Femara Fempro Legemiddel: Anastrozol Gitt PO Andre navn: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Legemiddel: Eksemestan Gitt PO Andre navn: Aromasin FCE-24304 Legemiddel: Tamoxifen Citrate Gitt PO Andre navn: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide Stråling: Strålebehandling Gjennomgå strålebehandling eller delvis brystbestråling Andre navn: Kreft Strålebehandling ENERGY_TYPE Bestråle Bestrålt Bestråling Stråling Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, stråling Energitype
Eksperimentell: Gruppe 3 (Oncotype DX-residivscore >= 26) Pasienter i denne gruppen får kombinasjonskjemoterapi etterfulgt av hormonbehandling tilsvarende pasientene i gruppe to som er tildelt begge typer behandling.	Annen: Laboratoriebiomarkøranalyse Korrelative studier Annen: Livskvalitetsvurdering Hjelpestudier Andre navn: Livskvalitetsvurdering Legemiddel: Letrozol Gitt PO Andre navn: CGS 20267 Femara Fempro Legemiddel: Anastrozol Gitt PO Andre navn: Arimidex Anastrazol ICI D1033 ICI-D1033 ZD-1033 Legemiddel: Eksemestan Gitt PO Andre navn: Aromasin FCE-24304 Legemiddel: Tamoxifen Citrate Gitt PO Andre navn: Nolvadex TAM Soltamox Apo-Tamox Clonoxifen Dignotamoxi Ebefen Emblon Østroxyn Fentamox Gen-Tamoxifen Genox ICI 46.474 ICI-46474 Jenoxifen Kessar Ledertam Lesporene Nolgen Noltam Nolvadex-D Nourytam Novo-Tamoxifen Novofen Noxitem Oestrifen Oncotam PMS-Tamoxifen Tamax Tamaxin Tamifen Tamizam Tamofen Tamoxasta Tamoxifeni Citras Zemide Stråling: Strålebehandling Gjennomgå strålebehandling eller delvis brystbestråling Andre navn: Kreft Strålebehandling ENERGY_TYPE Bestråle Bestrålt Bestråling Stråling Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, stråling Energitype

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
5-års sykdomsfri overlevelse Tidsramme: Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, DFS rate estimert til 5 år	Sykdomsfri overlevelse (DFS) er definert som tiden fra randomisering til første hendelse, der den første hendelsen er en hvilken som helst av ipsilateral brysttumor-residiv, lokalt residiv, regionalt residiv, fjernt residiv, kontralateral andre primær invasiv kreft, andre primære ikke-brystkreft. invasiv kreft (unntatt ikke-melanom hudkreft), eller død uten tegn på tilbakefall. Fordelingen av DFS (f.eks. 5-års DFS rate) er estimert ved hjelp av Kaplan-Meier metoden, og sammenlignet mellom de to randomiserte armene (arm B vs. arm C) ved bruk av stratifisert log rank test og stratifisert Cox proporsjonal hazard modell.	Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, DFS rate estimert til 5 år

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
5-års intervall uten gjentakelse Tidsramme: Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opptil 20 år, DRFI-rate estimert til 5 år	Distant recidiv-free interval (DRFI) er definert som tiden fra datoen for randomisering eller registrering til datoen for fjernt tilbakefall av brystkreft, eller for død med fjernt residiv, hvis døden er den første manifestasjonen av fjernt tilbakefall. Fordelingen av DRFI (f.eks. 5-års DRFI-rate) estimeres ved hjelp av Kaplan-Meier-metoden.	Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opptil 20 år, DRFI-rate estimert til 5 år
5-års intervall uten gjentakelse Tidsramme: Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, RFS rate estimert til 5 år	Residivfritt intervall (RFS) er definert som tiden fra dato for randomisering eller registrering til dato for første tilbakefall av brystkreft (ipsilateral brystsvulst tilbakefall, lokalt/regionalt residiv, fjernt tilbakefall) eller til dødsdato med tilbakefall, hvis døden er den første manifestasjonen av gjentakelse. Fordelingen av RFS (f.eks. 5-års RFS rate) estimeres ved hjelp av Kaplan-Meier-metoden.	Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, RFS rate estimert til 5 år
5-års total overlevelse Tidsramme: Vurderes hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, OS rate estimert til 5 år	Total overlevelse (OS) er definert som tiden fra dato for randomisering eller registrering til dato for død uansett årsak. Fordelingen av OS (f.eks. 5-års OS rate) estimeres ved hjelp av Kaplan-Meier-metoden.	Vurderes hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, OS rate estimert til 5 år
5-års sykdomsfri overlevelse etter alders- og tilbakefallspoenggrupper Tidsramme: Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, DFS rate estimert til 5 år	Sykdomsfri overlevelse (DFS) er definert som tiden fra randomisering til første hendelse, der den første hendelsen er en hvilken som helst av ipsilateral brysttumor-residiv, lokalt residiv, regionalt residiv, fjernt residiv, kontralateral andre primær invasiv kreft, andre primære ikke-brystkreft. invasiv kreft (unntatt ikke-melanom hudkreft), eller død uten tegn på tilbakefall. DFS blir evaluert etter residivscore (0-10 vs. 11-15 vs. 16-20 vs. 21-25 vs. >25) og aldersgrupper (	Vurdert hver 6. måned innen 5 år fra registrering og deretter årlig opp til 20 år, DFS rate estimert til 5 år
For å sammenligne resultatene anslått etter 10 år av adjuvant! Med de laget av Genomic Health Oncotype DX Test Tidsramme: Vurderes til 10 år etter studiestart	Adjuvans! er ikke tilgjengelig for øyeblikket; tilleggsarbeid som kombinerer klassisk informasjon med genomiske tester vil bli rapportert separat.	Vurderes til 10 år etter studiestart
5-års sykdomsfri overlevelse av individuelle RS-gengrupper Tidsramme: Vurderes hver 6. måned innen 5 år fra registrering og deretter årlig inntil 20 år	Sykdomsfri overlevelse (DFS) er definert som tiden fra randomisering til første hendelse, der den første hendelsen er en hvilken som helst av ipsilateral brysttumor-residiv, lokalt residiv, regionalt residiv, fjernt residiv, kontralateral andre primær invasiv kreft, andre primære ikke-brystkreft. invasiv kreft (unntatt ikke-melanom hudkreft), eller død uten tegn på tilbakefall. Fordelingen av DFS (f.eks. 5-års DFS rate) estimeres ved hjelp av Kaplan-Meier-metoden. 5-års DFS av individuelle RS-gengrupper (Proliferation Gene Group, HER2 Gene Group, ER Gene Group, Invasion Gene Group og Other Geners) vil bli estimert i hver arm.	Vurderes hver 6. måned innen 5 år fra registrering og deretter årlig inntil 20 år

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

National Cancer Institute (NCI)

Samarbeidspartnere

NCIC Clinical Trials Group

Cancer and Leukemia Group B

North Central Cancer Treatment Group

NSABP Foundation Inc

American College of Surgeons

SWOG Cancer Research Network

Etterforskere

Hovedetterforsker: Joseph A Sparano, ECOG-ACRIN Cancer Research Group

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Hjelpsomme linker

Data Available: Select individual patient-level data from this trial can be requested from the NCTN/NCORP Data Archive.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (Faktiske)

7. april 2006

Primær fullføring (Faktiske)

2. mars 2018

Studiet fullført (Antatt)

30. september 2030

Datoer for studieregistrering

Først innsendt

29. mars 2006

Først innsendt som oppfylte QC-kriteriene

29. mars 2006

Først lagt ut (Antatt)

3. april 2006

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

4. april 2024

Siste oppdatering sendt inn som oppfylte QC-kriteriene

3. april 2024

Sist bekreftet

1. mars 2024

Mer informasjon

Begreper knyttet til denne studien

Andre studie-ID-numre

NCI-2009-00707 (Registeridentifikator: CTRP (Clinical Trial Reporting Program))
U10CA180820 (U.S. NIH-stipend/kontrakt)
U10CA021115 (U.S. NIH-stipend/kontrakt)
ECOG-PACCT-1
06-482
CDR0000472066
PACCT-1 (Annen identifikator: CTEP)

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Kliniske studier på Hormonreseptor positiv

National Institute of Environmental Health Sciences...

Fullført

Effekter av spedbarnsdietter på østrogenaktivitet og utvikling

Hormon

Forente stater
Clinique Ovo

Avsluttet

Anti-Mullerian Hormone Levels Before and After an Open Myomectomy

Anti-Mullerian Hormon

Canada
University of Padova

Fullført

Effekt av inntak av melk fra mennesker, ku og modifisert ku, på glukose- og hormonresponser hos mennesker. (PROLAT)

Hormon | Insulintoleranse | Aminoacidemi
Beckman Coulter, Inc.

Fullført

Evaluering av klinisk ytelse av AMH-analyse

Anti-Mullerian Hormon

Canada, Forente stater
ART Fertility Clinics LLC

Fullført

Måling av forskjellige anti-Müllerske hormonisoformer hos forventede dårlige respondere

Anti-Mullerian Hormon isoformer

De forente arabiske emirater
ART Fertility Clinics LLC

Fullført

Evaluering av AMH-nivåene under naturlig syklus

Anti-Mullerian Hormon Resistens

De forente arabiske emirater
Samsung Medical Center

Ukjent

Effekten av gynekologisk kirurgi på ovariefunksjon hos kvinner i reproduktiv alder: Postoperative endringer av serum anti-müllerisk hormon (AMH)

Ovarial Reserve | Gynekologiske operasjoner | Anti-Mullerian Hormon
Instituto Valenciano de Infertilidad, IVI VALENCIA

Fullført

Innvirkning av gonadotropinreseptorpolimorfismer på forholdet mellom serum AMH og ovarierespons (GREPAMOR)

antimüllerisk hormon- og gonadotropinreseptorpolymorfisme som prediktorer for ovarierespons

Spania
University of East Anglia
Ministry of Defence, United Kingdom; Clinical Research and Trials Unit... og andre samarbeidspartnere

Ukjent

Studie av Teriparatide i Stress Fracture Healing (RETURN)

Stressbrudd | Parathyroid hormon

Storbritannia
Kanuni Sultan Suleyman Training and Research Hospital

Fullført

Ovarial reserve hos pasienter med psoriasis

Psoriasis | Ovarial Reserve | Anti-mullersk hormon

Tyrkia

Kliniske studier på Laboratoriebiomarkøranalyse

Fondation Lenval

Tilbaketrukket

Påvirkning av utmattelse på gangmønsteret hos pasienter med cerebral parese.

Cerebral parese

Frankrike
Liao Jian An

Rekruttering

Meridianenergiendringer hos pasienter med hode- og nakkekreft etter kjemoterapi eller strålebehandling

Hode- og nakkekreft

Taiwan
Progenity, Inc.

Fullført

Utvidet ikke-invasiv genomisk medisinsk vurdering: Enigma-studien

Downs syndrom | Aneuploidi | DiGeorge syndrom | Turners syndrom | Klinefelters syndrom | Kromosomsletting | Edwards syndrom | Patau syndrom

Forente stater
Tel-Aviv Sourasky Medical Center

Ukjent

Evaluering av evnen til CT-basert endelig elementanalyse (CTFEA) til å forutsi frakturer hos pasienter med metastaser: en randomisert kontrollert studie. (ZYCTFEA)

Benmetastaser | Ortopedisk lidelse | Benneoplasma i hoften (diagnose) | Proksimal femoral metafyseal abnormitet
IRCCS Eugenio Medea

Rekruttering

Biomarkørers baner for tidlig intervensjon hos søsken til barn med autismespekterforstyrrelse

Autismespektrumforstyrrelse | Tidlig intervensjon

Italia
Oregon Health and Science University
4DMedical

Påmelding etter invitasjon

Ventilasjonsubalanser ved mild til moderat kronisk obstruktiv lungesykdom (VAPOR)

Lungesykdommer | KOLS | Luftveissykdom | Dyspné

Forente stater
IRCCS Eugenio Medea

Rekruttering

Bekreft ytelsen i klinisk praksis til den oppslukende virtuelle virkelighetsplattformen GRAIL (Gait Real-time Analysis Interactive Lab)

Cerebral parese | Ervervet hjerneskade

Italia
Duke University

Tilbaketrukket

Point of Care-testing for å forbedre overvåking av LVAD-pasienter

Antikoagulasjons- og trombosepunkttest (AT-POCT)

Forente stater
Modarres Hospital

Fullført

Renal parenkymal kjernenålbiopsi

Komplikasjoner | Bildeveiledet biopsi | Nyre Glomerulus

Iran, den islamske republikken
University of California, Los Angeles

Fullført

Sikkerhet ved kroppssammensetningsanalyse hos hjertesviktpasienter med implanterbare cardioverter-defibrillatorer (ICD)

Hjertefeil | Overvekt

Forente stater

Hormonterapi med eller uten kombinasjonskjemoterapi ved behandling av kvinner som har gjennomgått kirurgi for node-negativ brystkreft (The TAILORx Trial) (TAILORx)

Program for vurdering av kliniske krefttester (PACCT-1): Forsøk som tildeler individuelle behandlingsalternativer: TAILORx-prøven

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Samarbeidspartnere

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Hjelpsomme linker

Studierekorddatoer

Studer hoveddatoer

Studiestart (Faktiske)

Primær fullføring (Faktiske)

Studiet fullført (Antatt)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (Antatt)

Oppdateringer av studieposter

Sist oppdatering lagt ut (Faktiske)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

Kliniske studier på Hormonreseptor positiv

Kliniske studier på Laboratoriebiomarkøranalyse

Søk i lignende forsøk

Sponsorer og samarbeidspartnere

Medisinsk tilstand

Legemiddelintervensjoner

CROs by country

CROs in Estonia

Forhold

Sjeldne sykdommer

Legemiddelintervensjoner

Kosttilskudd

Sponsor / samarbeidspartnere

Steder