Doxorubicinhydrochlorid, cyclophosphamid og paclitaxel med eller uden bevacizumab til behandling af patienter med lymfeknudepositiv eller højrisiko lymfeknude-negativ brystkræft
3. april 2024 opdateret af: National Cancer Institute (NCI)
Et dobbeltblindt fase III-forsøg med doxorubicin og cyclophosphamid efterfulgt af paclitaxel med bevacizumab eller placebo hos patienter med lymfeknudepositiv og højrisiko lymfeknudenegativ brystkræft
Dette randomiserede fase III-forsøg undersøger doxorubicinhydrochlorid, cyclophosphamid og paclitaxel for at se, hvor godt de virker med eller uden bevacizumab til behandling af patienter med kræft, der har spredt sig til lymfeknuderne (lymfeknude-positiv) eller kræft, der ikke har spredt sig til lymfen. noder, men har høj risiko for at vende tilbage (højrisiko, lymfeknude-negativ brystkræft).
Lægemidler, der bruges i kemoterapi, såsom doxorubicinhydrochlorid, cyclophosphamid og paclitaxel, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig.
Monoklonale antistoffer, såsom bevacizumab, kan interferere med tumorcellernes evne til at vokse og sprede sig.
Bevacizumab kan også stoppe væksten af brystkræft ved at blokere blodtilførslen til tumoren.
At give kemoterapi efter operationen kan dræbe eventuelle tumorceller, der er tilbage efter operationen, og hjælpe med at forhindre tumoren i at vende tilbage.
Det vides endnu ikke, om doxorubicinhydrochlorid, cyclophosphamid og paclitaxel er mere effektive med eller uden bevacizumab.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Detaljeret beskrivelse
PRIMÆRE MÅL:
I. For at bestemme den sygdomsfrie overlevelse af patienter (defineret som invasiv sygdomsfri overlevelse [IFDS]) med lymfeknudepositiv og højrisiko lymfeknudenegativ brystkræft randomiseret til behandling med enten doxorubicin (doxorubicinhydrochlorid)/cyclophosphamid plus placebo fulgte med paclitaxel (AC + placebo > T + placebo) eller samme kemoterapiregime plus bevacizumab.
SEKUNDÆRE MÅL:
I. At sammenligne kortvarig (20-24 uger) versus langvarig (50-54 uger) behandling med bevacizumab.
II. At sammenligne den samlede overlevelse. III. For at vurdere toksicitet. IV. At evaluere sammenhængen mellem resultater i E5103 (sygdomsfri overlevelse, generel overlevelse og toksiciteter) og genotype (afledt af kandidat-enkeltnukleotid-polymorfismer og genomomfattende evalueringer).
V. At sammenligne livskvaliteten for brystkræftpatienter behandlet med AC/paclitaxel og bevacizumab eller placebo med hensyn til fysiske symptomer, fysisk funktion, psykologisk tilstand og social funktion over en 18 måneders periode.
VI. At bestemme virkningen af teoretisk biomarkørinformation på patienters vilje til at acceptere toksiciteten af bevacizumab til den estimerede potentielle fordel.
VII. At skabe et bioprøvelager inklusive plasma-, serum- og CellSearch-kassetter indeholdende cirkulerende tumorceller (CTC) til evaluering af determinanter for sent tilbagefald, herunder kandidatbiomarkører, der afspejler okkult tumorbyrde (f.eks. CTC'er og plasmatumor deoxyribonukleinsyre [DNA]) og værtsfaktorer ( fx østrogen, insulin-insulin-lignende vækstfaktor [IGF]-akse, inflammation osv.).
VIII. At skabe et biodepot af metastatiske tumorprøver hos patienter, der har haft et sent tilbagefald.
IX. At bestemme body mass index (BMI) og komorbiditetsbyrde hos patienter med operabel brystkræft fem eller flere år efter diagnosen.
X. At bestemme om der er en sammenhæng mellem sent tilbagefald og BMI ved diagnose og 5 år efter diagnose, og om BMI-associerede inflammatoriske og/eller metaboliske biomarkører er forbundet med tidligt og sent recidiv.
OVERSIGT: Patienterne randomiseres til 1 ud af 3 behandlingsarme.
ARM I: Patienterne får doxorubicinhydrochlorid intravenøst (IV), cyclophosphamid IV over 20-30 minutter og placebo IV over 30-90 minutter på dag 1. Behandlingen gentages hver 2. eller 3. uge i 4 forløb. Begyndende 3 uger senere får patienterne derefter paclitaxel IV over 1 time på dag 1, 8 og 15 og placebo IV over 30-90 minutter på dag 1. Behandling med paclitaxel og placebo gentages hver 3. uge i 4 forløb.
ARM II: Patienterne får doxorubicinhydrochlorid og cyclophosphamid som i arm I og bevacizumab IV over 30-90 minutter på dag 1. Behandlingen gentages hver 2. eller 3. uge i 4 forløb. Begyndende 3 uger senere får patienterne derefter paclitaxel som i arm I og bevacizumab IV over 30-90 minutter på dag 1. Behandling med paclitaxel og bevacizumab gentages hver 3. uge i 4 forløb.
ARM III: Patienterne får doxorubicinhydrochlorid og cyclophosphamid som i arm I og bevacizumab som i arm II. Behandlingen gentages hver 2. eller 3. uge i 4 forløb. Begyndende 3 uger senere får patienterne derefter paclitaxel som i arm I og bevacizumab som i arm II. Behandling med paclitaxel og bevacizumab gentages hver 3. uge i 4 forløb. Fra 2 måneder senere får patienterne derefter bevacizumab IV over 30-90 minutter på dag 1. Behandling med bevacizumab alene gentages hver 3. uge i 10 forløb.
I alle arme fortsætter behandlingen i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afsluttet studiebehandling følges patienterne op i 15 år.
Undersøgelsestype
Interventionel
Tilmelding (Faktiske)
4994
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alabama
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Anniston, Alabama, Forenede Stater, 36202
- Northeast Alabama Regional Medical Center
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Birmingham, Alabama, Forenede Stater, 35233
- University of Alabama at Birmingham Cancer Center
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Mobile, Alabama, Forenede Stater, 36608
- Providence Hospital
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Alaska
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Regional Hospital
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Arizona
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Scottsdale, Arizona, Forenede Stater, 85259
- Mayo Clinic in Arizona
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Scottsdale, Arizona, Forenede Stater, 85258
- Virginia G Piper Cancer Care-Del Camino
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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California
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Antioch, California, Forenede Stater, 94531
- Kaiser Permanente-Deer Valley Medical Center
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burlingame, California, Forenede Stater, 94010
- Mills-Peninsula Medical Center
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Castro Valley, California, Forenede Stater, 94546
- East Bay Radiation Oncology Center
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Castro Valley, California, Forenede Stater, 94546
- Valley Medical Oncology Consultants-Castro Valley
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Emeryville, California, Forenede Stater, 94608
- Bay Area Breast Surgeons Inc
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Fremont, California, Forenede Stater, 94538
- Kaiser Permanente-Fremont
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Fremont, California, Forenede Stater, 94538
- Valley Medical Oncology Consultants-Fremont
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Fremont, California, Forenede Stater, 94538
- Washington Hospital
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Fresno, California, Forenede Stater, 93720
- California Cancer Associates for Research and Excellence (cCare)
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Glendale, California, Forenede Stater, 91204
- Glendale Memorial Hospital and Health Center
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Greenbrae, California, Forenede Stater, 94904
- Marin Cancer Care Inc
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Greenbrae, California, Forenede Stater, 94904
- Marin General Hospital
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La Jolla, California, Forenede Stater, 92093
- UC San Diego Moores Cancer Center
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Los Angeles, California, Forenede Stater, 90033
- USC / Norris Comprehensive Cancer Center
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Martinez, California, Forenede Stater, 94553-3156
- Contra Costa Regional Medical Center
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Marysville, California, Forenede Stater, 95901
- Fremont - Rideout Cancer Center
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Monterey, California, Forenede Stater, 93940
- Community Hospital of Monterey Peninsula
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Mountain View, California, Forenede Stater, 94040
- El Camino Hospital
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Oakland, California, Forenede Stater, 94611
- Kaiser Permanente-Oakland
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Oakland, California, Forenede Stater, 94609
- Alta Bates Summit Medical Center - Summit Campus
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Oakland, California, Forenede Stater, 94609
- Hematology and Oncology Associates-Oakland
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Oakland, California, Forenede Stater, 94602
- Highland General Hospital
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Oakland, California, Forenede Stater, 94609
- Tom K Lee Inc
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Oakland, California, Forenede Stater, 94609
- Bay Area Tumor Institute
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Palm Springs, California, Forenede Stater, 92262
- Desert Regional Medical Center
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Palo Alto, California, Forenede Stater, 94304
- Stanford Cancer Institute Palo Alto
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Pleasanton, California, Forenede Stater, 94588
- Valley Care Health System - Pleasanton
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Pleasanton, California, Forenede Stater, 94588
- Valley Medical Oncology Consultants
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Pomona, California, Forenede Stater, 91767
- Pomona Valley Hospital Medical Center
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Rancho Mirage, California, Forenede Stater, 92270
- Eisenhower Medical Center
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Redwood City, California, Forenede Stater, 94063
- Kaiser Permanente-Redwood City
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Richmond, California, Forenede Stater, 94801
- Kaiser Permanente-Richmond
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Roseville, California, Forenede Stater, 95661
- Kaiser Permanente-Roseville
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95823
- Kaiser Permanente-South Sacramento
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Sacramento, California, Forenede Stater, 95825
- Kaiser Permanente - Sacramento
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Saint Helena, California, Forenede Stater, 94574
- Saint Helena Hospital
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Salinas, California, Forenede Stater, 93901
- Salinas Valley Memorial
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San Diego, California, Forenede Stater, 92108
- Kaiser Permanente-San Diego Mission
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San Diego, California, Forenede Stater, 92123
- Sharp Memorial Hospital
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San Diego, California, Forenede Stater, 92103
- UC San Diego Medical Center - Hillcrest
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San Francisco, California, Forenede Stater, 94115
- Kaiser Permanente-San Francisco
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Francisco, California, Forenede Stater, 94115
- UCSF Medical Center-Mount Zion
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San Francisco, California, Forenede Stater, 94110
- Zuckerberg San Francisco General Hospital
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San Jose, California, Forenede Stater, 95119
- Kaiser Permanente-Santa Teresa-San Jose
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San Leandro, California, Forenede Stater, 94577
- Kaiser Permanente San Leandro
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San Pablo, California, Forenede Stater, 94806
- Doctors Medical Center- JC Robinson Regional Cancer Center
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San Rafael, California, Forenede Stater, 94903
- Kaiser Permanente-San Rafael
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Santa Clara, California, Forenede Stater, 95051
- Kaiser Permanente Medical Center - Santa Clara
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Santa Rosa, California, Forenede Stater, 95403
- Kaiser Permanente-Santa Rosa
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South San Francisco, California, Forenede Stater, 94080
- Kaiser Permanente-South San Francisco
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Stockton, California, Forenede Stater, 95210
- Kaiser Permanente-Stockton
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Truckee, California, Forenede Stater, 96161
- Gene Upshaw Memorial Tahoe Forest Cancer Center
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Vallejo, California, Forenede Stater, 94589
- Kaiser Permanente-Vallejo
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Walnut Creek, California, Forenede Stater, 94596
- Kaiser Permanente-Walnut Creek
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80909
- UCHealth Memorial Hospital Central
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80205
- Kaiser Permanente-Franklin
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80222
- Western States Cancer Research NCORP
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Fort Collins, Colorado, Forenede Stater, 80524
- Poudre Valley Hospital
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Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Kaiser Permanente-Rock Creek
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Forenede Stater, 80229
- North Suburban Medical Center
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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Connecticut
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Danbury, Connecticut, Forenede Stater, 06810
- Danbury Hospital
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Hartford, Connecticut, Forenede Stater, 06105
- Smilow Cancer Hospital Care Center at Saint Francis
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Middletown, Connecticut, Forenede Stater, 06457
- Middlesex Hospital
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New Britain, Connecticut, Forenede Stater, 06050
- The Hospital of Central Connecticut
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Norwalk, Connecticut, Forenede Stater, 06856
- Norwalk Hospital
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Stamford, Connecticut, Forenede Stater, 06904
- Stamford Hospital/Bennett Cancer Center
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Torrington, Connecticut, Forenede Stater, 06790
- Smilow Cancer Hospital-Torrington Care Center
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Delaware
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Dover, Delaware, Forenede Stater, 19901
- Bayhealth Hospital Kent Campus
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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District of Columbia
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Washington, District of Columbia, Forenede Stater, 20010
- MedStar Washington Hospital Center
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Washington, District of Columbia, Forenede Stater, 20007
- MedStar Georgetown University Hospital
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Washington, District of Columbia, Forenede Stater, 20016
- Sibley Memorial Hospital
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Washington, District of Columbia, Forenede Stater, 20037
- George Washington University Medical Center
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Washington, District of Columbia, Forenede Stater, 20060
- Howard University Hospital
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Florida
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Boca Raton, Florida, Forenede Stater, 33486
- Boca Raton Regional Hospital
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Boca Raton, Florida, Forenede Stater, 33428
- Lynn Regional Cancer Center - West
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Boca Raton, Florida, Forenede Stater, 33486
- Boca Raton Comprehensive Cancer Center
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Daytona Beach, Florida, Forenede Stater, 32114
- Halifax Health Medical Center-Centers for Oncology
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Deerfield Beach, Florida, Forenede Stater, 33064
- Broward Health North
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Fort Lauderdale, Florida, Forenede Stater, 33316
- Broward Health Medical Center
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Gainesville, Florida, Forenede Stater, 32605
- Florida Cancer Specialists-Gainesville Cancer Center
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Hollywood, Florida, Forenede Stater, 33021
- Memorial Regional Hospital/Joe DiMaggio Children's Hospital
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Jacksonville, Florida, Forenede Stater, 32224-9980
- Mayo Clinic in Florida
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Jupiter, Florida, Forenede Stater, 33458
- Jupiter Medical Center
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Lakeland, Florida, Forenede Stater, 33805
- Lakeland Regional Health Hollis Cancer Center
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Lakeland, Florida, Forenede Stater, 33805
- The Watson Clinic
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Leesburg, Florida, Forenede Stater, 34788
- Cancer Centers of Central Florida PA
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Miami, Florida, Forenede Stater, 33136
- University of Miami Miller School of Medicine-Sylvester Cancer Center
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Miami Beach, Florida, Forenede Stater, 33140
- Mount Sinai Medical Center
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Orlando, Florida, Forenede Stater, 32803
- AdventHealth Orlando
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Weston, Florida, Forenede Stater, 33331
- Cleveland Clinic-Weston
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Georgia
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Athens, Georgia, Forenede Stater, 30607
- University Cancer and Blood Center LLC
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Atlanta, Georgia, Forenede Stater, 30342
- Emory Saint Joseph's Hospital
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Atlanta, Georgia, Forenede Stater, 30303
- Grady Health System
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Atlanta, Georgia, Forenede Stater, 30309
- Piedmont Hospital
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Atlanta, Georgia, Forenede Stater, 30342
- Northside Hospital
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Atlanta, Georgia, Forenede Stater, 30342
- Atlanta Regional CCOP
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Augusta, Georgia, Forenede Stater, 30912
- Augusta University Medical Center
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Austell, Georgia, Forenede Stater, 30106
- WellStar Cobb Hospital
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Columbus, Georgia, Forenede Stater, 31904
- John B Amos Cancer Center
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Decatur, Georgia, Forenede Stater, 30033
- Dekalb Medical Center
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Fort Gordon, Georgia, Forenede Stater, 30905-5650
- Eisenhower Army Medical Center
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Gainesville, Georgia, Forenede Stater, 30501
- Northeast Georgia Medical Center-Gainesville
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Lawrenceville, Georgia, Forenede Stater, 30046
- Northside Hospital - Gwinnett
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Macon, Georgia, Forenede Stater, 31201
- Medical Center of Central Georgia
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Marietta, Georgia, Forenede Stater, 30060
- Wellstar Kennestone Hospital
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Riverdale, Georgia, Forenede Stater, 30274
- Southern Regional Medical Center
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Rome, Georgia, Forenede Stater, 30165
- Harbin Clinic Medical Oncology and Clinical Research
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Savannah, Georgia, Forenede Stater, 31404
- Memorial Health University Medical Center
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Wailuku, Hawaii, Forenede Stater, 96793
- Maui Memorial Medical Center
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Wailuku, Hawaii, Forenede Stater, 96793
- Pacific Cancer Institute of Maui
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Health
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Berwyn, Illinois, Forenede Stater, 60402
- MacNeal Hospital and Cancer Center
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Canton, Illinois, Forenede Stater, 61520
- Graham Hospital Association
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Carthage, Illinois, Forenede Stater, 62321
- Memorial Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60612
- Rush University Medical Center
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Chicago, Illinois, Forenede Stater, 60637
- University of Chicago Comprehensive Cancer Center
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Chicago, Illinois, Forenede Stater, 60612
- University of Illinois
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Chicago, Illinois, Forenede Stater, 60612
- John H Stroger Jr Hospital of Cook County
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Chicago, Illinois, Forenede Stater, 60657
- UChicago Medicine Comprehensive Cancer Center - Saint Joseph Hospital
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Chicago, Illinois, Forenede Stater, 60608
- Mount Sinai Hospital Medical Center
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Chicago, Illinois, Forenede Stater, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Hematology and Oncology Associates
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Chicago, Illinois, Forenede Stater, 60631
- Presence Resurrection Medical Center
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Chicago, Illinois, Forenede Stater, 60640
- Weiss Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Heartland Cancer Research NCORP
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Elgin, Illinois, Forenede Stater, 60123
- Advocate Sherman Hospital
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Elk Grove Village, Illinois, Forenede Stater, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Elmhurst, Illinois, Forenede Stater, 60126
- Elmhurst Memorial Hospital
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Eureka, Illinois, Forenede Stater, 61530
- Eureka Hospital
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Evanston, Illinois, Forenede Stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Evanston, Illinois, Forenede Stater, 60202
- Saint Francis Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Galesburg, Illinois, Forenede Stater, 61401
- Galesburg Cottage Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Cottage
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Harvey, Illinois, Forenede Stater, 60426
- Ingalls Memorial Hospital
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Havana, Illinois, Forenede Stater, 62644
- Mason District Hospital
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Havana, Illinois, Forenede Stater, 62644
- Illinois CancerCare-Havana
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Highland Park, Illinois, Forenede Stater, 60035
- Hematology Oncology Associates of Illinois-Highland Park
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Hinsdale, Illinois, Forenede Stater, 60521
- Hinsdale Hematology Oncology Associates Incorporated
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Hopedale, Illinois, Forenede Stater, 61747
- Hopedale Medical Complex - Hospital
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Joliet, Illinois, Forenede Stater, 60435
- Duly Health and Care Joliet
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Joliet, Illinois, Forenede Stater, 60432
- Midwest Center for Hematology Oncology
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Kankakee, Illinois, Forenede Stater, 60901
- Presence Saint Mary's Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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La Grange, Illinois, Forenede Stater, 60525
- AMITA Health Adventist Medical Center
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Libertyville, Illinois, Forenede Stater, 60048
- AMG Libertyville - Oncology
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Macomb, Illinois, Forenede Stater, 61455
- Mcdonough District Hospital
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Moline, Illinois, Forenede Stater, 61265
- Garneau, Stewart C MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Porubcin, Michael MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Spector, David MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
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Moline, Illinois, Forenede Stater, 61265
- Sharis, Christine M MD (UIA Investigator)
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Moline, Illinois, Forenede Stater, 61265
- Stoffel, Thomas J MD (UIA Investigator)
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Monmouth, Illinois, Forenede Stater, 61462
- Illinois CancerCare-Monmouth
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Monmouth, Illinois, Forenede Stater, 61462
- Holy Family Medical Center
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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Naperville, Illinois, Forenede Stater, 60563
- DuPage Medical Group-Ogden
-
Niles, Illinois, Forenede Stater, 60714
- Illinois Cancer Specialists-Niles
-
Normal, Illinois, Forenede Stater, 61761
- Carle Cancer Institute Normal
-
Normal, Illinois, Forenede Stater, 61761
- Bromenn Regional Medical Center
-
Normal, Illinois, Forenede Stater, 61761
- Illinois CancerCare-Community Cancer Center
-
Normal, Illinois, Forenede Stater, 61761
- Mid-Illinois Hematology Oncology Associates Limited
-
Oak Lawn, Illinois, Forenede Stater, 60453-2699
- Advocate Christ Medical Center
-
Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
-
Ottawa, Illinois, Forenede Stater, 61350
- Ottawa Regional Hospital and Healthcare Center
-
Park Ridge, Illinois, Forenede Stater, 60068
- Advocate Lutheran General Hospital
-
Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
-
Pekin, Illinois, Forenede Stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
-
Pekin, Illinois, Forenede Stater, 61554
- Pekin Hospital
-
Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
-
Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
-
Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
-
Peoria, Illinois, Forenede Stater, 61614
- Proctor Hospital
-
Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
-
Peru, Illinois, Forenede Stater, 61354
- Illinois Valley Hospital
-
Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
-
Princeton, Illinois, Forenede Stater, 61356
- Perry Memorial Hospital
-
River Forest, Illinois, Forenede Stater, 60305
- West Suburban Medical Center
-
Rockford, Illinois, Forenede Stater, 61108
- OSF Saint Anthony Medical Center
-
Rockford, Illinois, Forenede Stater, 61104
- Swedish American Hospital
-
Skokie, Illinois, Forenede Stater, 60076
- Hematology Oncology Associates of Illinois - Skokie
-
Skokie, Illinois, Forenede Stater, 60076
- Edward H Kaplan MD and Associates
-
Spring Valley, Illinois, Forenede Stater, 61362
- Saint Margaret's Hospital
-
Spring Valley, Illinois, Forenede Stater, 61362
- Illinois CancerCare-Spring Valley
-
Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
-
Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Winfield, Illinois, Forenede Stater, 60190
- Northwestern Medicine Central DuPage Hospital
-
-
Indiana
-
Anderson, Indiana, Forenede Stater, 46016
- Ascension Saint Vincent Anderson
-
Beech Grove, Indiana, Forenede Stater, 46107
- Franciscan Saint Francis Health-Beech Grove
-
Bloomington, Indiana, Forenede Stater, 47408
- IU Health Bloomington
-
Elkhart, Indiana, Forenede Stater, 46515
- Elkhart General Hospital
-
Elkhart, Indiana, Forenede Stater, 46514
- Michiana Hematology Oncology PC-Elkhart
-
Elkhart, Indiana, Forenede Stater, 46514-2098
- Elkhart Clinic
-
Fort Wayne, Indiana, Forenede Stater, 46845
- Fort Wayne Medical Oncology and Hematology Inc-Parkview
-
Goshen, Indiana, Forenede Stater, 46526
- Goshen Center for Cancer Care
-
Indianapolis, Indiana, Forenede Stater, 46237
- Franciscan Health Indianapolis
-
Indianapolis, Indiana, Forenede Stater, 46202
- Indiana University/Melvin and Bren Simon Cancer Center
-
Indianapolis, Indiana, Forenede Stater, 46260
- Ascension Saint Vincent Indianapolis Hospital
-
Indianapolis, Indiana, Forenede Stater, 46202
- Sidney and Lois Eskenazi Hospital
-
Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
-
La Porte, Indiana, Forenede Stater, 46350
- IU Health La Porte Hospital
-
Lafayette, Indiana, Forenede Stater, 47904
- IU Health Arnett Cancer Care
-
Lafayette, Indiana, Forenede Stater, 47905
- Horizon Oncology Research LLC
-
Merrillville, Indiana, Forenede Stater, 46410
- Premier Oncology Hematology Associates
-
Michigan City, Indiana, Forenede Stater, 46360
- Franciscan Saint Anthony Health-Michigan City
-
Mishawaka, Indiana, Forenede Stater, 46545
- Michiana Hematology Oncology PC-Mishawaka
-
Mishawaka, Indiana, Forenede Stater, 46545
- Saint Joseph Regional Medical Center-Mishawaka
-
Muncie, Indiana, Forenede Stater, 47303
- IU Health Ball Memorial Hospital
-
Munster, Indiana, Forenede Stater, 46321
- The Community Hospital
-
Plymouth, Indiana, Forenede Stater, 46563
- Michiana Hematology Oncology PC-Plymouth
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
South Bend, Indiana, Forenede Stater, 46601
- Memorial Hospital of South Bend
-
South Bend, Indiana, Forenede Stater, 46601
- Michiana Hematology Oncology PC-South Bend
-
South Bend, Indiana, Forenede Stater, 46628
- Northern Indiana Cancer Research Consortium
-
South Bend, Indiana, Forenede Stater, 46617
- South Bend Clinic
-
Westville, Indiana, Forenede Stater, 46391
- Michiana Hematology Oncology PC-Westville
-
-
Iowa
-
Ames, Iowa, Forenede Stater, 50010
- McFarland Clinic - Ames
-
Bettendorf, Iowa, Forenede Stater, 52722
- Constantinou, Costas L MD (UIA Investigator)
-
Bettendorf, Iowa, Forenede Stater, 52722
- University of Iowa Healthcare Cancer Services Quad Cities
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Mercy Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52403
- Oncology Associates at Mercy Medical Center
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Saint Luke's Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Heartland Oncology and Hematology LLP
-
Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
-
Davenport, Iowa, Forenede Stater, 52804
- Genesis Cancer Care Institute
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa-Wide Oncology Research Coalition NCORP
-
Des Moines, Iowa, Forenede Stater, 50307
- Mercy Capitol
-
Mason City, Iowa, Forenede Stater, 50401
- Mercy Medical Center - North Iowa
-
Ottumwa, Iowa, Forenede Stater, 52501
- Ottumwa Regional Health Center
-
Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Regional Cancer Center
-
Sioux City, Iowa, Forenede Stater, 51102
- Mercy Medical Center-Sioux City
-
Sioux City, Iowa, Forenede Stater, 51104
- Saint Luke's Regional Medical Center
-
Waterloo, Iowa, Forenede Stater, 50701
- Cedar Valley Medical Specialists
-
Waterloo, Iowa, Forenede Stater, 50702
- MercyOne Waterloo Cancer Center
-
-
Kansas
-
Chanute, Kansas, Forenede Stater, 66720
- Cancer Center of Kansas - Chanute
-
Dodge City, Kansas, Forenede Stater, 67801
- Cancer Center of Kansas - Dodge City
-
El Dorado, Kansas, Forenede Stater, 67042
- Cancer Center of Kansas - El Dorado
-
Fort Scott, Kansas, Forenede Stater, 66701
- Cancer Center of Kansas - Fort Scott
-
Independence, Kansas, Forenede Stater, 67301
- Cancer Center of Kansas-Independence
-
Kansas City, Kansas, Forenede Stater, 66160
- University of Kansas Cancer Center
-
Kingman, Kansas, Forenede Stater, 67068
- Cancer Center of Kansas-Kingman
-
Lawrence, Kansas, Forenede Stater, 66044
- Lawrence Memorial Hospital
-
Liberal, Kansas, Forenede Stater, 67905
- Cancer Center of Kansas-Liberal
-
Liberal, Kansas, Forenede Stater, 67901
- Southwest Medical Center
-
Newton, Kansas, Forenede Stater, 67114
- Cancer Center of Kansas - Newton
-
Olathe, Kansas, Forenede Stater, 66061
- Olathe Cancer Center
-
Parsons, Kansas, Forenede Stater, 67357
- Cancer Center of Kansas - Parsons
-
Pratt, Kansas, Forenede Stater, 67124
- Cancer Center of Kansas - Pratt
-
Salina, Kansas, Forenede Stater, 67401
- Salina Regional Health Center
-
Salina, Kansas, Forenede Stater, 67401
- Cancer Center of Kansas - Salina
-
Topeka, Kansas, Forenede Stater, 66606
- University of Kansas Health System Saint Francis Campus
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
Wellington, Kansas, Forenede Stater, 67152
- Cancer Center of Kansas - Wellington
-
Wichita, Kansas, Forenede Stater, 67214
- Ascension Via Christi Hospitals Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Cancer Center of Kansas-Wichita Medical Arts Tower
-
Wichita, Kansas, Forenede Stater, 67214
- Cancer Center of Kansas - Wichita
-
Wichita, Kansas, Forenede Stater, 67208
- Associates In Womens Health
-
Wichita, Kansas, Forenede Stater, 67214
- Wichita NCI Community Oncology Research Program
-
Winfield, Kansas, Forenede Stater, 67156
- Cancer Center of Kansas - Winfield
-
-
Kentucky
-
Ashland, Kentucky, Forenede Stater, 41101
- King's Daughter's Medical Center
-
Louisville, Kentucky, Forenede Stater, 40202
- The James Graham Brown Cancer Center at University of Louisville
-
Louisville, Kentucky, Forenede Stater, 40215
- Doctors Carrol, Sheth, Raghavan
-
Owensboro, Kentucky, Forenede Stater, 42303
- Owensboro Health Mitchell Memorial Cancer Center
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Mary Bird Perkins Cancer Center
-
Baton Rouge, Louisiana, Forenede Stater, 70809
- Ochsner Health Center-Summa
-
Baton Rouge, Louisiana, Forenede Stater, 70806
- Baton Rouge General Medical Center
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Health Center-Covington
-
Mansfield, Louisiana, Forenede Stater, 71052
- DeSoto Regional Health System
-
Monroe, Louisiana, Forenede Stater, 71202
- Ochsner LSU Health Monroe Medical Center
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
New Orleans, Louisiana, Forenede Stater, 70112
- University Medical Center New Orleans
-
New Orleans, Louisiana, Forenede Stater, 70112
- Louisiana State University Health Science Center
-
Shreveport, Louisiana, Forenede Stater, 71103
- LSU Health Sciences Center at Shreveport
-
Shreveport, Louisiana, Forenede Stater, 71105
- Highland Clinic
-
-
Maine
-
Augusta, Maine, Forenede Stater, 04330
- Harold Alfond Center for Cancer Care
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Lewiston, Maine, Forenede Stater, 04240
- Central Maine Medical Center
-
Scarborough, Maine, Forenede Stater, 04074
- Maine Center for Cancer Medicine-Scarborough
-
Waterville, Maine, Forenede Stater, 04901
- Maine General Medical Center-Thayer
-
York, Maine, Forenede Stater, 03909
- York Hospital
-
-
Maryland
-
Annapolis, Maryland, Forenede Stater, 21401
- Anne Arundel Medical Center
-
Baltimore, Maryland, Forenede Stater, 21237
- MedStar Franklin Square Medical Center/Weinberg Cancer Institute
-
Baltimore, Maryland, Forenede Stater, 21287
- Johns Hopkins University/Sidney Kimmel Cancer Center
-
Baltimore, Maryland, Forenede Stater, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Forenede Stater, 21201
- University of Maryland/Greenebaum Cancer Center
-
Baltimore, Maryland, Forenede Stater, 21218
- MedStar Union Memorial Hospital
-
Baltimore, Maryland, Forenede Stater, 21239
- MedStar Good Samaritan Hospital
-
Bethesda, Maryland, Forenede Stater, 20814
- Suburban Hospital
-
Easton, Maryland, Forenede Stater, 21601
- University of Maryland Shore Medical Center at Easton
-
Elkton, Maryland, Forenede Stater, 21921
- Christiana Care - Union Hospital
-
Frederick, Maryland, Forenede Stater, 21701
- Frederick Memorial Hospital
-
Kensington, Maryland, Forenede Stater, 20895
- Associates in Oncology Hematology PC -Kensington
-
Rockville, Maryland, Forenede Stater, 20850
- Maryland Oncology Hematology PA-Aquilino Cancer Center
-
Silver Spring, Maryland, Forenede Stater, 20910
- Holy Cross Hospital
-
-
Massachusetts
-
Attleboro, Massachusetts, Forenede Stater, 02703
- Sturdy Memorial Hospital
-
Boston, Massachusetts, Forenede Stater, 02215
- Beth Israel Deaconess Medical Center
-
Boston, Massachusetts, Forenede Stater, 02215
- Dana-Farber Cancer Institute
-
Boston, Massachusetts, Forenede Stater, 02115
- Brigham and Women's Hospital
-
Boston, Massachusetts, Forenede Stater, 02111
- Tufts Medical Center
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Boston, Massachusetts, Forenede Stater, 02114
- Massachusetts General Hospital Cancer Center
-
Brighton, Massachusetts, Forenede Stater, 02135
- Steward Saint Elizabeth's Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Framingham, Massachusetts, Forenede Stater, 01702
- MetroWest Medical Center-Framingham Union Hospital
-
Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
-
Hyannis, Massachusetts, Forenede Stater, 02601
- Cape Cod Hospital
-
Lowell, Massachusetts, Forenede Stater, 01854
- Lowell General Hospital
-
Norwood, Massachusetts, Forenede Stater, 02062
- Norwood Hospital
-
Pittsfield, Massachusetts, Forenede Stater, 01201
- Berkshire Medical Center - Cancer Center
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Saint Joseph Mercy Hospital
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Michigan Cancer Research Consortium NCORP
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Big Rapids, Michigan, Forenede Stater, 49307
- Spectrum Health Big Rapids Hospital
-
Dearborn, Michigan, Forenede Stater, 48124
- Beaumont Hospital - Dearborn
-
Detroit, Michigan, Forenede Stater, 48201
- Wayne State University/Karmanos Cancer Institute
-
Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
-
Escanaba, Michigan, Forenede Stater, 49829
- Green Bay Oncology - Escanaba
-
Flint, Michigan, Forenede Stater, 48532
- Genesys Regional Medical Center-West Flint Campus
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Cancer Research Consortium of West Michigan NCORP
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Trinity Health Grand Rapids Hospital
-
Holland, Michigan, Forenede Stater, 49423
- Holland Community Hospital
-
Iron Mountain, Michigan, Forenede Stater, 49801
- Green Bay Oncology - Iron Mountain
-
Jackson, Michigan, Forenede Stater, 49201
- Allegiance Health
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49048
- Borgess Medical Center
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Midland, Michigan, Forenede Stater, 48670
- MyMichigan Medical Center Midland
-
Mount Clemens, Michigan, Forenede Stater, 48043
- McLaren Cancer Institute-Macomb
-
Muskegon, Michigan, Forenede Stater, 49442
- Mercy Health Partners-Hackley Campus
-
Muskegon, Michigan, Forenede Stater, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Forenede Stater, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Petoskey, Michigan, Forenede Stater, 49770
- McLaren Cancer Institute-Northern Michigan
-
Pontiac, Michigan, Forenede Stater, 48341
- Saint Joseph Mercy Oakland
-
Port Huron, Michigan, Forenede Stater, 48060
- Lake Huron Medical Center
-
Royal Oak, Michigan, Forenede Stater, 48073
- William Beaumont Hospital-Royal Oak
-
Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Oncology Care Associates PLLC
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Southfield, Michigan, Forenede Stater, 48075
- Ascension Providence Hospitals - Southfield
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
Wyoming, Michigan, Forenede Stater, 49519
- University of Michigan Health - West
-
-
Minnesota
-
Alexandria, Minnesota, Forenede Stater, 56308
- Medini, Eitan MD (UIA Investigator)
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Duluth, Minnesota, Forenede Stater, 55805
- Saint Luke's Hospital of Duluth
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Etzell, Paul S MD (UIA Investigator)
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Swenson, Wade II, MD (UIA Investigator)
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hutchinson, Minnesota, Forenede Stater, 55350
- Hutchinson Area Health Care
-
Litchfield, Minnesota, Forenede Stater, 55355
- Meeker County Memorial Hospital
-
Mankato, Minnesota, Forenede Stater, 56001
- Mayo Clinic Health Systems-Mankato
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55455
- University of Minnesota/Masonic Cancer Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Virginia Piper Cancer Institute
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Rochester, Minnesota, Forenede Stater, 55905
- Mayo Clinic in Rochester
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Coborn Cancer Center at Saint Cloud Hospital
-
Saint Cloud, Minnesota, Forenede Stater, 56303
- Saint Cloud Hospital
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Metro Minnesota Community Oncology Research Consortium
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- Saint Joseph's Hospital - Healtheast
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Woodbury, Minnesota, Forenede Stater, 55125
- Woodwinds Health Campus
-
-
Mississippi
-
Keesler Air Force Base, Mississippi, Forenede Stater, 39534
- Keesler Medical Center
-
-
Missouri
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63701
- Southeast Missouri Hospital
-
Chesterfield, Missouri, Forenede Stater, 63017
- Saint Luke's Hospital
-
Columbia, Missouri, Forenede Stater, 65201
- Veterans Administration
-
Columbia, Missouri, Forenede Stater, 65212
- MU Health - University Hospital/Ellis Fischel Cancer Center
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Saint Charles, Missouri, Forenede Stater, 63301
- Missouri Cancer Care PC - Saint Charles
-
Saint Louis, Missouri, Forenede Stater, 63110
- Washington University School of Medicine
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Saint Louis, Missouri, Forenede Stater, 63141
- Saint Louis-Cape Girardeau CCOP
-
Saint Louis, Missouri, Forenede Stater, 63141
- Center for Cancer Care and Research
-
Saint Louis, Missouri, Forenede Stater, 63141
- Comprehensive Cancer Care PC
-
Springfield, Missouri, Forenede Stater, 65804
- Cancer Research for the Ozarks NCORP
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
-
Montana
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59102
- Montana Cancer Consortium NCORP
-
Billings, Montana, Forenede Stater, 59101
- Northern Rockies Radiation Oncology Center
-
Billings, Montana, Forenede Stater, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Great Falls, Montana, Forenede Stater, 59405
- Berdeaux, Donald MD (UIA Investigator)
-
Havre, Montana, Forenede Stater, 59501
- Northern Montana Hospital
-
Helena, Montana, Forenede Stater, 59601
- Saint Peter's Community Hospital
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Kalispell, Montana, Forenede Stater, 59901
- Glacier Oncology PLLC
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Medical Oncology
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
Missoula, Montana, Forenede Stater, 59804
- Guardian Oncology and Center for Wellness
-
Missoula, Montana, Forenede Stater, 59802
- Montana Cancer Specialists
-
-
Nebraska
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Forenede Stater, 68510
- Nebraska Cancer Research Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68106
- Missouri Valley Cancer Consortium
-
Omaha, Nebraska, Forenede Stater, 68106
- Cancer Alliance of Nebraska
-
-
Nevada
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89169
- Nevada Cancer Research Foundation NCORP
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Dover, New Hampshire, Forenede Stater, 03820
- Wentworth-Douglass Hospital
-
Exeter, New Hampshire, Forenede Stater, 03833
- Exeter Hospital
-
Keene, New Hampshire, Forenede Stater, 03431
- Cheshire Medical Center-Dartmouth-Hitchcock Keene
-
Laconia, New Hampshire, Forenede Stater, 03246
- LRGHealthcare-Lakes Region General Hospital
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, Forenede Stater, 03102
- Norris Cotton Cancer Center-Manchester
-
Manchester, New Hampshire, Forenede Stater, 03103
- Solinsky Center for Cancer Care
-
Nashua, New Hampshire, Forenede Stater, 03060
- Foundation Medical Partners
-
-
New Jersey
-
Brick, New Jersey, Forenede Stater, 08724
- Ocean University Medical Center
-
Camden, New Jersey, Forenede Stater, 08103
- Cooper Hospital University Medical Center
-
Englewood, New Jersey, Forenede Stater, 07631
- Englewood Hospital and Medical Center
-
Flemington, New Jersey, Forenede Stater, 08822
- Hunterdon Medical Center
-
Hackensack, New Jersey, Forenede Stater, 07601
- Hackensack University Medical Center
-
Hamilton, New Jersey, Forenede Stater, 08690
- The Cancer Institute of New Jersey Hamilton
-
Livingston, New Jersey, Forenede Stater, 07039
- Saint Barnabas Medical Center
-
Morristown, New Jersey, Forenede Stater, 07960
- Morristown Medical Center
-
Mount Holly, New Jersey, Forenede Stater, 08060
- Virtua Memorial
-
Neptune, New Jersey, Forenede Stater, 07753
- Jersey Shore Medical Center
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Rutgers Cancer Institute of New Jersey
-
New Brunswick, New Jersey, Forenede Stater, 08901
- Saint Peter's University Hospital
-
Newark, New Jersey, Forenede Stater, 07101
- Rutgers New Jersey Medical School
-
Newark, New Jersey, Forenede Stater, 07112
- Newark Beth Israel Medical Center
-
Newark, New Jersey, Forenede Stater, 07102
- Saint Michael's Medical Center
-
Paterson, New Jersey, Forenede Stater, 07503
- Saint Joseph's Regional Medical Center
-
Pennington, New Jersey, Forenede Stater, 08534
- Capital Health Medical Center-Hopewell
-
Pomona, New Jersey, Forenede Stater, 08240
- AtlantiCare Regional Medical Center -Main Campus
-
Red Bank, New Jersey, Forenede Stater, 07701
- Riverview Medical Center/Booker Cancer Center
-
Ridgewood, New Jersey, Forenede Stater, 07450
- Valley Hospital
-
Sparta, New Jersey, Forenede Stater, 07871
- Sparta Cancer Treatment Center
-
Summit, New Jersey, Forenede Stater, 07902
- Overlook Hospital
-
Vineland, New Jersey, Forenede Stater, 08360
- Inspira Medical Center Vineland
-
Voorhees, New Jersey, Forenede Stater, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- University of New Mexico Cancer Center
-
Albuquerque, New Mexico, Forenede Stater, 87102
- Lovelace Medical Center-Saint Joseph Square
-
Albuquerque, New Mexico, Forenede Stater, 87106
- Hematology Oncology Associates
-
Albuquerque, New Mexico, Forenede Stater, 87110
- Presbyterian Kaseman Hospital
-
Las Cruces, New Mexico, Forenede Stater, 88011
- Memorial Medical Center - Las Cruces
-
San Juan, New Mexico, Forenede Stater, 87401
- San Juan Regional Medical Center
-
-
New York
-
Albany, New York, Forenede Stater, 12206
- New York Oncology Hematology PC - Albany
-
Albany, New York, Forenede Stater, 12208
- New York Oncology Hematology PC - Albany Medical Center
-
Amsterdam, New York, Forenede Stater, 12010
- New York Oncology Hematology PC - Amsterdam
-
Bronx, New York, Forenede Stater, 10467
- Montefiore Medical Center - Moses Campus
-
Bronx, New York, Forenede Stater, 10461
- Montefiore Medical Center-Weiler Hospital
-
Bronx, New York, Forenede Stater, 10466
- Montefiore Medical Center-Wakefield Campus
-
Bronx, New York, Forenede Stater, 10451
- Lincoln Medical and Mental Health Center
-
Brooklyn, New York, Forenede Stater, 11219
- Maimonides Medical Center
-
Brooklyn, New York, Forenede Stater, 11235
- Coney Island Hospital
-
Buffalo, New York, Forenede Stater, 14263
- Roswell Park Cancer Institute
-
Clifton Park, New York, Forenede Stater, 12065
- New York Oncology Hematology PC - Clifton Park
-
Clifton Springs, New York, Forenede Stater, 14432
- Finger Lakes Hematology and Oncology
-
Cooperstown, New York, Forenede Stater, 13326
- Mary Imogene Bassett Hospital
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Elmhurst, New York, Forenede Stater, 11373
- Elmhurst Hospital Center
-
Elmira, New York, Forenede Stater, 14905
- Arnot Ogden Medical Center/Falck Cancer Center
-
Hudson, New York, Forenede Stater, 12534
- New York Oncology Hematology PC-Hudson
-
Jamaica, New York, Forenede Stater, 11432
- Queens Hospital Center
-
Middletown, New York, Forenede Stater, 10940
- Garnet Health Medical Center
-
Mount Kisco, New York, Forenede Stater, 10549
- Northern Westchester Hospital
-
Mount Kisco, New York, Forenede Stater, 10549-3417
- Mount Kisco Medical Group at Northern Westchester Hospital
-
New York, New York, Forenede Stater, 10065
- Memorial Sloan Kettering Cancer Center
-
New York, New York, Forenede Stater, 10019
- Mount Sinai West
-
New York, New York, Forenede Stater, 10029
- Mount Sinai Hospital
-
New York, New York, Forenede Stater, 10032
- NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
-
New York, New York, Forenede Stater, 10065
- NYP/Weill Cornell Medical Center
-
New York, New York, Forenede Stater, 10016
- Laura and Isaac Perlmutter Cancer Center at NYU Langone
-
New York, New York, Forenede Stater, 10003
- Mount Sinai Union Square
-
Plattsburgh, New York, Forenede Stater, 12901
- Champlain Valley Physicians Hospital Medical Center
-
Poughkeepsie, New York, Forenede Stater, 12601
- Vassar Brothers Medical Center
-
Poughkeepsie, New York, Forenede Stater, 12601
- Hudson Valley Hematology Oncology Associates
-
Poughkeepsie, New York, Forenede Stater, 12601
- The Dyson Center for Cancer Care
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Rochester, New York, Forenede Stater, 14620
- Highland Hospital
-
Rochester, New York, Forenede Stater, 14623
- Interlakes Foundation Inc-Rochester
-
Staten Island, New York, Forenede Stater, 10305
- Staten Island University Hospital
-
Staten Island, New York, Forenede Stater, 10310
- Richmond University Medical Center
-
Stony Brook, New York, Forenede Stater, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
Troy, New York, Forenede Stater, 12180
- New York Oncology Hematology PC - Troy
-
Utica, New York, Forenede Stater, 13502
- Faxton-Saint Luke's Healthcare
-
-
North Carolina
-
Asheboro, North Carolina, Forenede Stater, 27203
- Randolph Hospital
-
Asheville, North Carolina, Forenede Stater, 28801
- Mission Hospital
-
Asheville, North Carolina, Forenede Stater, 28816
- Hope Women's Cancer Centers-Asheville
-
Burlington, North Carolina, Forenede Stater, 27215
- Cone Health Cancer Center at Alamance Regional
-
Cary, North Carolina, Forenede Stater, 27518
- Waverly Hematology Oncology
-
Chapel Hill, North Carolina, Forenede Stater, 27599
- UNC Lineberger Comprehensive Cancer Center
-
Charlotte, North Carolina, Forenede Stater, 28204
- Novant Health Presbyterian Medical Center
-
Concord, North Carolina, Forenede Stater, 28025
- Atrium Health Cabarrus/LCI-Concord
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Southeastern Medical Oncology Center-Goldsboro
-
Goldsboro, North Carolina, Forenede Stater, 27534
- Wayne Memorial Hospital
-
Greensboro, North Carolina, Forenede Stater, 27403
- Cone Health Cancer Center
-
Greenville, North Carolina, Forenede Stater, 27834
- East Carolina University
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Margaret R Pardee Memorial Hospital
-
Kinston, North Carolina, Forenede Stater, 28501
- Vidant Oncology-Kinston
-
Pinehurst, North Carolina, Forenede Stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Raleigh, North Carolina, Forenede Stater, 27607
- UNC Rex Healthcare
-
Reidsville, North Carolina, Forenede Stater, 27320
- Annie Penn Memorial Hospital
-
Rutherfordton, North Carolina, Forenede Stater, 28139
- Rutherford Hospital
-
Washington, North Carolina, Forenede Stater, 27889
- Marion L Shepard Cancer Center at Vidant Beaufort Hospital
-
Winston-Salem, North Carolina, Forenede Stater, 27157
- Wake Forest University Health Sciences
-
Winston-Salem, North Carolina, Forenede Stater, 27104
- Southeast Clinical Oncology Research Consortium NCORP
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Bismarck, North Dakota, Forenede Stater, 58501
- Mid Dakota Clinic
-
Bismarck, North Dakota, Forenede Stater, 58501
- Saint Alexius Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Clinic North-Fargo
-
Grand Forks, North Dakota, Forenede Stater, 58201
- Altru Cancer Center
-
Minot, North Dakota, Forenede Stater, 58701
- Trinity Cancer Care Center
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Bellefontaine, Ohio, Forenede Stater, 43311
- Mary Rutan Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, Forenede Stater, 44710
- Aultman Health Foundation
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45219
- The Christ Hospital
-
Cleveland, Ohio, Forenede Stater, 44106
- Case Western Reserve University
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43210
- Ohio State University Comprehensive Cancer Center
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Columbus, Ohio, Forenede Stater, 43215
- Columbus NCI Community Oncology Research Program
-
Dayton, Ohio, Forenede Stater, 45406
- Good Samaritan Hospital - Dayton
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45405
- Grandview Hospital
-
Dayton, Ohio, Forenede Stater, 45459
- Dayton NCI Community Oncology Research Program
-
Dayton, Ohio, Forenede Stater, 45428
- Dayton Veterans Affairs Medical Center
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wilmington, Ohio, Forenede Stater, 45177
- Clinton Memorial Hospital
-
Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
- Wright-Patterson Medical Center
-
Xenia, Ohio, Forenede Stater, 45385
- Greene Memorial Hospital
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Norman, Oklahoma, Forenede Stater, 73071
- Cancer Care Associates-Norman
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Physicians of Oklahoma-Lakeside
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Cancer Care Associates
-
Tulsa, Oklahoma, Forenede Stater, 74136
- Natalie Warren Bryant Cancer Center at Saint Francis
-
-
Oregon
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Grants Pass, Oregon, Forenede Stater, 97527
- Three Rivers Community Hospital
-
Gresham, Oregon, Forenede Stater, 97030
- Legacy Mount Hood Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Asante Health System
-
Medford, Oregon, Forenede Stater, 97504
- Providence Medford Medical Center
-
Medford, Oregon, Forenede Stater, 97504
- Rogue Valley Medical Center
-
Milwaukie, Oregon, Forenede Stater, 97222
- Providence Milwaukie Hospital
-
Portland, Oregon, Forenede Stater, 97239
- Oregon Health and Science University
-
Portland, Oregon, Forenede Stater, 97210
- Legacy Good Samaritan Hospital and Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Kaiser Permanente Northwest
-
Portland, Oregon, Forenede Stater, 97227
- Legacy Emanuel Hospital and Health Center
-
Portland, Oregon, Forenede Stater, 97216
- Adventist Medical Center
-
Portland, Oregon, Forenede Stater, 97227
- Compass Oncology Rose Quarter
-
Salem, Oregon, Forenede Stater, 97301
- Salem Hospital
-
Tualatin, Oregon, Forenede Stater, 97062
- Legacy Meridian Park Hospital
-
-
Pennsylvania
-
Abington, Pennsylvania, Forenede Stater, 19001
- Jefferson Abington Hospital
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Bethlehem, Pennsylvania, Forenede Stater, 18015
- Saint Luke's University Hospital-Bethlehem Campus
-
Bryn Mawr, Pennsylvania, Forenede Stater, 19010
- Bryn Mawr Hospital
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
Darby, Pennsylvania, Forenede Stater, 19023-1291
- Mercy Fitzgerald Hospital
-
Doylestown, Pennsylvania, Forenede Stater, 18901
- Doylestown Hospital
-
Drexel Hill, Pennsylvania, Forenede Stater, 19026
- Delaware County Memorial Hospital
-
DuBois, Pennsylvania, Forenede Stater, 15801
- Oncology Hematology Associates of Northern Pennsylvania
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Easton, Pennsylvania, Forenede Stater, 18042
- Easton Hospital
-
Ephrata, Pennsylvania, Forenede Stater, 17522
- Ephrata Cancer Center
-
Erie, Pennsylvania, Forenede Stater, 16505
- UPMC Hillman Cancer Center Erie
-
Erie, Pennsylvania, Forenede Stater, 16544
- Saint Vincent Hospital
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Kittanning, Pennsylvania, Forenede Stater, 16201
- Armstrong Center for Medicine and Health
-
Lancaster, Pennsylvania, Forenede Stater, 17602
- Lancaster General Hospital
-
Langhorne, Pennsylvania, Forenede Stater, 19047
- Saint Mary Medical and Regional Cancer Center
-
Lemoyne, Pennsylvania, Forenede Stater, 17043
- Central PA Hematology-Medical Oncology Associates PC
-
Lewistown, Pennsylvania, Forenede Stater, 17044
- Lewistown Hospital
-
Meadowbrook, Pennsylvania, Forenede Stater, 19046
- Holy Redeemer Hospital and Medical Center
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Memorial Hospital
-
Paoli, Pennsylvania, Forenede Stater, 19301
- Paoli Memorial Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19111
- Fox Chase Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Thomas Jefferson University Hospital
-
Philadelphia, Pennsylvania, Forenede Stater, 19104
- University of Pennsylvania/Abramson Cancer Center
-
Philadelphia, Pennsylvania, Forenede Stater, 19141
- Einstein Medical Center Philadelphia
-
Philadelphia, Pennsylvania, Forenede Stater, 19107
- Pennsylvania Hospital
-
Phoenixville, Pennsylvania, Forenede Stater, 19460
- Phoenixville Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15212
- Allegheny General Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pottstown, Pennsylvania, Forenede Stater, 19464
- Pottstown Hospital
-
Reading, Pennsylvania, Forenede Stater, 19605
- Penn State Health Saint Joseph Medical Center
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Scranton Hematology Oncology
-
Scranton, Pennsylvania, Forenede Stater, 18501
- Mercy Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18508
- Hematology and Oncology Associates of North East Pennsylvania
-
Sellersville, Pennsylvania, Forenede Stater, 18960
- Grand View Hospital
-
State College, Pennsylvania, Forenede Stater, 16801
- Geisinger Medical Group
-
State College, Pennsylvania, Forenede Stater, 16803
- Mount Nittany Medical Center
-
West Chester, Pennsylvania, Forenede Stater, 19380
- Chester County Hospital
-
West Grove, Pennsylvania, Forenede Stater, 19390
- Jennersville Regional Hospital
-
West Reading, Pennsylvania, Forenede Stater, 19611
- Reading Hospital
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18765
- Geisinger South Wilkes-Barre
-
Williamsport, Pennsylvania, Forenede Stater, 17701
- UPMC Susquehanna
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Lankenau Medical Center
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Main Line Health NCORP
-
York, Pennsylvania, Forenede Stater, 17403
- WellSpan Health-York Hospital
-
-
Rhode Island
-
Providence, Rhode Island, Forenede Stater, 02903
- Rhode Island Hospital
-
Providence, Rhode Island, Forenede Stater, 02905
- Women and Infants Hospital
-
Providence, Rhode Island, Forenede Stater, 02906
- Miriam Hospital
-
Warwick, Rhode Island, Forenede Stater, 02886
- Kent Hospital
-
-
South Carolina
-
Anderson, South Carolina, Forenede Stater, 29621
- AnMed Health Hospital
-
Charleston, South Carolina, Forenede Stater, 29425
- Medical University of South Carolina
-
Charleston, South Carolina, Forenede Stater, 29401
- Roper Hospital
-
Florence, South Carolina, Forenede Stater, 29506
- McLeod Regional Medical Center
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
-
South Dakota
-
Aberdeen, South Dakota, Forenede Stater, 57401
- Avera Cancer Institute-Aberdeen
-
Rapid City, South Dakota, Forenede Stater, 57701
- Rapid City Regional Hospital
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Avera Cancer Institute
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5134
- Sanford USD Medical Center - Sioux Falls
-
Sioux Falls, South Dakota, Forenede Stater, 57104
- Sanford Cancer Center Oncology Clinic
-
Sioux Falls, South Dakota, Forenede Stater, 57105
- Medical X-Ray Center
-
Sioux Falls, South Dakota, Forenede Stater, 57117-5045
- Avera McKennan Hospital and University Health Center
-
-
Tennessee
-
Bristol, Tennessee, Forenede Stater, 37620
- Wellmont Medical Associates Oncology and Hematology-Bristol
-
Chattanooga, Tennessee, Forenede Stater, 37403
- Erlanger Medical Center
-
Franklin, Tennessee, Forenede Stater, 37067
- Vanderbilt-Ingram Cancer Center Cool Springs
-
Kingsport, Tennessee, Forenede Stater, 37660
- Wellmont Holston Valley Hospital and Medical Center
-
Knoxville, Tennessee, Forenede Stater, 37916
- Thompson Cancer Survival Center
-
Knoxville, Tennessee, Forenede Stater, 37920
- University of Tennessee - Knoxville
-
Memphis, Tennessee, Forenede Stater, 38163
- University of Tennessee Health Science Center
-
Nashville, Tennessee, Forenede Stater, 37232
- Vanderbilt University/Ingram Cancer Center
-
Nashville, Tennessee, Forenede Stater, 37204
- Vanderbilt Breast Center at One Hundred Oaks
-
Nashville, Tennessee, Forenede Stater, 37208
- Meharry Medical College
-
Nashville, Tennessee, Forenede Stater, 37203
- Nashville Oncology Associates PC
-
-
Texas
-
Dallas, Texas, Forenede Stater, 75235
- Parkland Memorial Hospital
-
Dallas, Texas, Forenede Stater, 75390
- UT Southwestern/Simmons Cancer Center-Dallas
-
Dallas, Texas, Forenede Stater, 75230
- Medical City Dallas Hospital
-
Dallas, Texas, Forenede Stater, 75390
- Clements University Hospital
-
Fort Sam Houston, Texas, Forenede Stater, 78234
- Brooke Army Medical Center
-
Houston, Texas, Forenede Stater, 77030
- Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
-
Lackland Air Force Base, Texas, Forenede Stater, 78236
- Wilford Hall Medical Center
-
Temple, Texas, Forenede Stater, 76508
- Scott and White Memorial Hospital
-
-
Utah
-
Salt Lake City, Utah, Forenede Stater, 84112
- Huntsman Cancer Institute/University of Utah
-
-
Vermont
-
Bennington, Vermont, Forenede Stater, 05201
- Southwestern Vermont Medical Center
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
-
Virginia
-
Charlottesville, Virginia, Forenede Stater, 22908
- University of Virginia Cancer Center
-
Fairfax, Virginia, Forenede Stater, 22031
- Inova Schar Cancer Institute
-
Gloucester, Virginia, Forenede Stater, 23061
- Peninsula Cancer Institute-Gloucester
-
Lynchburg, Virginia, Forenede Stater, 24501
- Centra Lynchburg Hematology-Oncology Clinic Inc
-
Newport News, Virginia, Forenede Stater, 23601
- Peninsula Cancer Institute-Newport News
-
Norton, Virginia, Forenede Stater, 24273
- Southwest VA Regional Cancer Center
-
Williamsburg, Virginia, Forenede Stater, 23185
- Peninsula Cancer Institute-Williamsburg
-
-
Washington
-
Auburn, Washington, Forenede Stater, 98001
- MultiCare Auburn Medical Center
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Olympia, Washington, Forenede Stater, 98506-5166
- Providence - Saint Peter Hospital
-
Puyallup, Washington, Forenede Stater, 98372
- MultiCare Good Samaritan Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Tacoma General Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- MultiCare Allenmore Hospital
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest NCI Community Oncology Research Program
-
Tacoma, Washington, Forenede Stater, 98405
- Saint Joseph Medical Center
-
Vancouver, Washington, Forenede Stater, 98686
- Legacy Salmon Creek Hospital
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
-
West Virginia
-
Charleston, West Virginia, Forenede Stater, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Huntington, West Virginia, Forenede Stater, 25702
- Saint Mary's Medical Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Forenede Stater, 26101
- Camden Clark Medical Center
-
Princeton, West Virginia, Forenede Stater, 24740
- Princeton Community Hospital
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54911
- ThedaCare Regional Cancer Center
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Chippewa Falls, Wisconsin, Forenede Stater, 54729
- Marshfield Clinic-Chippewa Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- HSHS Sacred Heart Hospital
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Clinic Cancer Center at Sacred Heart
-
Fond Du Lac, Wisconsin, Forenede Stater, 54935
- Saint Agnes Hospital/Agnesian Cancer Center
-
Franklin, Wisconsin, Forenede Stater, 53132
- Aurora Cancer Care-Franklin
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Glendale, Wisconsin, Forenede Stater, 53212
- Aurora Cancer Care-Glendale
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Green Bay Oncology Limited at Saint Mary's Hospital
-
Green Bay, Wisconsin, Forenede Stater, 54301-3526
- Green Bay Oncology at Saint Vincent Hospital
-
Janesville, Wisconsin, Forenede Stater, 53548
- Mercyhealth Hospital and Cancer Center - Janesville
-
Johnson Creek, Wisconsin, Forenede Stater, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Mayo Clinic Health System-Franciscan Healthcare
-
Madison, Wisconsin, Forenede Stater, 53717
- Dean Hematology and Oncology Clinic
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Carbone Cancer Center
-
Manitowoc, Wisconsin, Forenede Stater, 54221
- Holy Family Memorial Hospital
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marinette, Wisconsin, Forenede Stater, 54143
- Bay Area Medical Center
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center
-
Mequon, Wisconsin, Forenede Stater, 53097
- Ascension Columbia Saint Mary's Hospital Ozaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53211
- Ascension Columbia Saint Mary's Hospital - Milwaukee
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oconto Falls, Wisconsin, Forenede Stater, 54154
- Saint Vincent Hospital Cancer Center at Oconto Falls
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Racine, Wisconsin, Forenede Stater, 53405
- Ascension All Saints Hospital
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Ascension Saint Michael's Hospital
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235
- Green Bay Oncology - Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Waukesha, Wisconsin, Forenede Stater, 53188
- Aurora Cancer Care-Waukesha
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wausau, Wisconsin, Forenede Stater, 54401
- Marshfield Clinic-Wausau Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Weston, Wisconsin, Forenede Stater, 54476
- Diagnostic and Treatment Center
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Marshfield Clinic - Wisconsin Rapids Center
-
-
Wyoming
-
Casper, Wyoming, Forenede Stater, 82609
- Rocky Mountain Oncology
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Lima, Peru, Lima 34
- Instituto Nacional de Enfermedades Neoplasicas
-
-
-
-
-
Pretoria, Sydafrika, 0002
- University Of Pretoria
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
Patienter skal have histologisk bekræftet adenokarcinom i brystet med betydelig risiko for fjernt tilbagefald baseret på mindst et af følgende kriterier:
For aksillær lymfeknudepositiv sygdom:
- Inddragelse af mindst én vagtpost eller aksillær lymfeknude ved rutinemæssig histologisk undersøgelse; patienter med negative sentinel noder og negative aksillære noder eller involvering kun påvist ved immunhistokemi er ikke kvalificerede, medmindre de opfylder et af de andre berettigelseskriterier nedenfor
- BEMÆRK: betragte intramammære noder som ækvivalente med aksillære noder med henblik på berettigelse og stratificering
For aksillær lymfeknude negativ sygdom:
- Østrogenreceptor (ER) negativ tumor >= 1 cm
- ER+ tumor >= 5 cm uanset recidivscore
- ER+ tumor >= 1 cm men < 5 cm med en recidivscore >= 11 (patienter, der er tilmeldt TAILORx forsøget er kvalificerede)
- BEMÆRK: aksillær dissektion tilskyndes kraftigt hos patienter med lymfeknudepåvirkning identificeret på sentinel node biopsi
Patienter skal have gennemført en endelig brystoperation inklusive total mastektomi og aksillær dissektion (modificeret radikal mastektomi), total mastektomi og vagtpostknudebiopsi, brystkonserveringskirurgi og aksillær dissektion eller brystkonserveringskirurgi og skildvagtsknudebiopsi
- BEMÆRK: Brystkonserveringskirurgi omfatter lumpektomi, partiel mastektomi og excisionsbiopsi
- Marginer af brystbevaringskirurgi eller mastektomi skal være histologisk fri for invasiv brystkræft og duktalt carcinom in situ (DCIS); patienter med resektionsmarginer positive for lobulært karcinom in situ (LCIS) er kvalificerede
- Tiden fra sidste operation for brystkræft (brystkonserveringskirurgi, mastektomi, sentinel node biopsi, aksillær dissektion eller re-ekscision af brystkonserveringskirurgiens marginer) til planlagt behandlingsstartdato skal være > 28 dage og =< 84 dage
- Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0-1
- Inden for =< 8 uger før randomisering: Absolut neutrofiltal >= 1.000/mm^3
- Inden for =< 8 uger før randomisering: Blodpladetal >= 100.000/mm^3
- Inden for =< 8 uger før randomisering: Total bilirubin =< 1,5 mg/dL
- Inden for =< 8 uger før randomisering: Aspartataminotransferase (AST) =< 2 gange øvre normalgrænse (ULN)
- Inden for =< 8 uger før randomisering: Serumkreatinin =< 1,5 mg/dL
- Inden for =< 8 uger før randomisering: Urinprotein:kreatinin-forhold < 1,0 eller 24-timers protein
- Inden for =< 8 uger før randomisering: Partiel tromboplastintid (PTT) =< 1,5 gange ULN
- Inden for =< 8 uger før randomisering: venstre ventrikel ejektionsfraktion (LVEF) >= institutionelle grænser for normal ved multigated acquisition scan (MUGA) eller ekkokardiogram (ECHO)
Patienter, der har gennemgået en brystbevaringsoperation, skal modtage stråling; Forud for randomisering skal investigator specificere den planlagte strålingsteknik:
- Helbryststråling (WBRT) efter kemoterapi
- Accelereret partiel bryststråling (APBI) efter kemoterapi
- Accelereret partiel bryststråling (APBI) før kemoterapi
- BEMÆRK: hvis APBI blev afsluttet før studiestart, skal dag 1 af protokolbehandling være mindst 4 uger efter afslutningen af APBI
- Post-mastektomi strålebehandling (RT) er påkrævet for alle patienter med en primær tumor på >= 5 cm eller involvering af 4 eller flere lymfeknuder; post-mastektomi RT kan administreres efter investigators skøn for alle andre mastektomipatienter
- Patienter med human epidermal vækstfaktorreceptor (HER)2+ (3+ ved immunhistokemi [IHC] eller fluorescerende in situ hybridisering [FISH] ratio >= 2) brystkræft er ikke kvalificerede
- Patienter med synkron bilateral brystkræft (diagnosticeret inden for en måned) er berettigede, hvis tumoren med højere tumor-, knude-, metastase- (TNM) stadium opfylder berettigelseskriterierne for dette forsøg
- Patienter må ikke have klinisk tegn på inflammatorisk sygdom eller fikserede aksillære knuder ved diagnosen
Patienter må ikke have modtaget forudgående cytotoksisk kemoterapi eller hormonbehandling for denne brystkræft; forudgående behandling med anthracyclin, anthracendion eller taxan for enhver tilstand er ikke tilladt
- BEMÆRK: tidligere brug af tamoxifen til kemoforebyggelse er tilladt, men skal afbrydes ved studiestart; på samme måde er tidligere brug af raloxifen tilladt, men skal afbrydes ved start af studiet
Patienter må ikke have haft nogen større kirurgisk indgreb inden for 28 dage efter planlagt behandlingsstartdato
- BEMÆRK: ikke-operativ biopsi eller placering af en vaskulær adgangsenhed betragtes ikke som en større operation
- Patienter har muligvis ikke fået anbragt en vaskulær adgangsanordning inden for 24 timer efter planlagt dag 1 af behandlingen
Patienter må ikke have klinisk signifikant kardiovaskulær eller cerebrovaskulær sygdom, herunder:
Enhver historie om
- Cerebrovaskulær sygdom, herunder forbigående iskæmisk anfald (TIA), slagtilfælde eller subaraknoidal blødning
- Iskæmisk tarm
Inden for de seneste 12 måneder
- Myokardieinfarkt
- Ustabil angina
- New York Heart Association (NYHA) klasse II eller større kongestiv hjertesvigt
- Grad II eller større perifer vaskulær sygdom
- Ukontrolleret hypertension defineret som systolisk blodtryk (SBP) > 160 eller diastolisk blodtryk (DBP) > 90
- Ukontrolleret eller klinisk signifikant arytmi
- BEMÆRK: blodtryk skal opnås inden for =< 8 uger før randomisering
- BEMÆRK: Patienter med kontrolleret atrieflimren er kvalificerede
Patienter, der har brug for fulddosis antikoagulering, kan tilmeldes, forudsat at de opfylder følgende kriterier:
- Patienten skal have en international normaliseret ratio (INR) inden for området (normalt mellem 2 og 3) på en stabil dosis warfarin eller være på en stabil dosis af lavmolekylært heparin (LMW)
- Patienten må ikke have aktiv blødning eller patologiske tilstande, der medfører høj risiko for blødning (f. varicer)
- BEMÆRK: profylaktisk brug af antikoagulantia for at opretholde åbenhed af en vaskulær adgangsenhed er tilladt
- Patienter må ikke have en blødende diatese, arvelig eller erhvervet blødningssygdom eller koagulopati
- Patienter må ikke have et ikke-helende sår eller brud; patienter med en abdominal fistel, gastrointestinal perforation eller intra-abdominal absces inden for 6 måneder før randomisering er ikke kvalificerede
- Patienter må ikke have overfølsomhed over for paclitaxel eller lægemidler, der anvender vehikelen Cremophor, ovariecelleprodukter fra kinesisk hamster eller andre rekombinante humane antistoffer
- Kvinder må ikke være gravide eller ammende; alle kvinder i den fødedygtige alder skal have en blod- eller urinprøve inden for 7 dage før randomisering for at udelukke graviditet
- Kvinder i den fødedygtige alder og seksuelt aktive mænd skal bruge en accepteret og effektiv præventionsmetode
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Aktiv komparator: Arm I (kemoterapi, placebo)
Patienterne får doxorubicinhydrochlorid IV, cyclophosphamid IV over 20-30 minutter og placebo IV over 30-90 minutter på dag 1.
Behandlingen gentages hver 2. eller 3. uge i 4 forløb.
Begyndende 3 uger senere får patienterne derefter paclitaxel IV over 1 time på dag 1, 8 og 15 og placebo IV over 30-90 minutter på dag 1.
Behandling med paclitaxel og placebo gentages hver 3. uge i 4 forløb.
|
Korrelative undersøgelser
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Givet IV
Andre navne:
Supplerende undersøgelser (lukket pr. 28/5/10)
Andre navne:
|
|
Eksperimentel: Arm II (kemoterapi, bevacizumab)
Patienterne får doxorubicinhydrochlorid og cyclophosphamid som i arm I og bevacizumab IV over 30-90 minutter på dag 1.
Behandlingen gentages hver 2. eller 3. uge i 4 forløb.
Begyndende 3 uger senere får patienterne derefter paclitaxel som i arm I og bevacizumab IV over 30-90 minutter på dag 1.
Behandling med paclitaxel og bevacizumab gentages hver 3. uge i 4 forløb.
|
Korrelative undersøgelser
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Supplerende undersøgelser (lukket pr. 28/5/10)
Andre navne:
|
|
Eksperimentel: Arm III (kemoterapi, bevacizumab monoterapi)
Patienterne får doxorubicinhydrochlorid og cyclophosphamid som i arm I og bevacizumab som i arm II.
Behandlingen gentages hver 2. eller 3. uge i 4 forløb.
Begyndende 3 uger senere får patienterne derefter paclitaxel som i arm I og bevacizumab som i arm II.
Behandling med paclitaxel og bevacizumab gentages hver 3. uge i 4 forløb.
Fra 2 måneder senere får patienterne derefter bevacizumab IV over 30-90 minutter på dag 1.
Behandling med bevacizumab alene gentages hver 3. uge i 10 forløb.
|
Korrelative undersøgelser
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Supplerende undersøgelser (lukket pr. 28/5/10)
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Invasiv sygdomsfri overlevelse (IDFS) rate ved 5 år
Tidsramme: Vurderet til 5 år
|
Invasiv sygdomsfri overlevelse (IDFS) blev defineret som tiden fra datoen for randomisering til første behandlingssvigt (invasiv ipsilateral, lokal/regional eller fjern recidiv, invasiv kontralateral brystkræft, invasiv ikke-bryst anden primær malignitet eller død af enhver årsag , alt efter hvad der skete først).
Tilfælde med ufuldstændig opfølgning, uden dokumenteret IDFS-hændelse, inklusive dem, der udviklede plade- eller basalcellehudkræft eller insitu-karcinomer på et hvilket som helst sted som deres eneste hændelse, blev censureret på datoen for sidste sygdomsevaluering.
|
Vurderet til 5 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
5-års samlet overlevelse (OS)
Tidsramme: Vurderet til 5 år
|
Samlet overlevelse (OS) blev defineret som tiden fra datoen for randomisering til død af enhver årsag, ellers blev tilfælde censureret på datoen for sidst kendt at være i live.
|
Vurderet til 5 år
|
|
Sammenhængen mellem IDFS og genotype
Tidsramme: Vurderet til 3 år
|
Invasiv sygdomsfri overlevelse (IDFS) er defineret som tiden fra datoen for randomisering til første behandlingssvigt (invasiv ipsilateral, lokal/regional eller fjern recidiv, invasiv kontralateral brystkræft, invasiv ikke-bryst anden primær malignitet eller død af enhver årsag , alt efter hvad der skete først).
Tilfælde med ufuldstændig opfølgning, uden dokumenteret IDFS-hændelse, inklusive dem, der udviklede plade- eller basalcellehudkræft eller insitu-karcinomer på et hvilket som helst sted som deres eneste hændelse, blev censureret på datoen for sidste sygdomsevaluering.
Tre-årig IDFS-rate blev rapporteret efter genetisk afstamning, og IDFS blev sammenlignet mellem patienter med europæisk herkomst og patienter med afrikansk aner.
|
Vurderet til 3 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Samarbejdspartnere
Efterforskere
- Ledende efterforsker: Kathy D Miller, ECOG-ACRIN Cancer Research Group
Publikationer og nyttige links
Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.
Generelle publikationer
- Rosenberg SM, O'Neill A, Sepucha K, Miller KD, Dang CT, Northfelt DW, Sledge GW, Schneider BP, Partridge AH. Quality of Life Following Receipt of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node-Positive and High-Risk Lymph Node-Negative Breast Cancer. JAMA Netw Open. 2022 Feb 1;5(2):e220254. doi: 10.1001/jamanetworkopen.2022.0254.
- Ip EH, Saldana S, Miller KD, Carlos RC, Gareen IF, Sparano JA, Graham N, Zhao F, Lee JW, O'Connell NS, Cella D, Peipert JD, Gray RJ, Wagner LI. Tolerability of bevacizumab and chemotherapy in a phase 3 clinical trial with human epidermal growth factor receptor 2-negative breast cancer: A trajectory analysis of adverse events. Cancer. 2021 Dec 15;127(24):4546-4556. doi: 10.1002/cncr.33992. Epub 2021 Nov 2.
- Sparano J, O'Neill A, Alpaugh K, Wolff AC, Northfelt DW, Dang CT, Sledge GW, Miller KD. Association of Circulating Tumor Cells With Late Recurrence of Estrogen Receptor-Positive Breast Cancer: A Secondary Analysis of a Randomized Clinical Trial. JAMA Oncol. 2018 Dec 1;4(12):1700-1706. doi: 10.1001/jamaoncol.2018.2574.
- Miller KD, O'Neill A, Gradishar W, Hobday TJ, Goldstein LJ, Mayer IA, Bloom S, Brufsky AM, Tevaarwerk AJ, Sparano JA, Le-Lindqwister NA, Hendricks CB, Northfelt DW, Dang CT, Sledge GW Jr. Double-Blind Phase III Trial of Adjuvant Chemotherapy With and Without Bevacizumab in Patients With Lymph Node-Positive and High-Risk Lymph Node-Negative Breast Cancer (E5103). J Clin Oncol. 2018 Sep 1;36(25):2621-2629. doi: 10.1200/JCO.2018.79.2028. Epub 2018 Jul 24.
- Partridge AH, Sepucha K, O'Neill A, Miller KD, Baker E, Dang CT, Northfelt DW, Sledge GW, Schneider BP. Does biomarker information impact breast cancer patients' preferences and physician recommendation for adjuvant chemotherapy? Breast Cancer Res Treat. 2017 Oct;165(3):545-553. doi: 10.1007/s10549-017-4338-x. Epub 2017 Jun 23.
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
2. november 2007
Primær færdiggørelse (Faktiske)
7. januar 2014
Studieafslutning (Anslået)
22. februar 2025
Datoer for studieregistrering
Først indsendt
8. februar 2007
Først indsendt, der opfyldte QC-kriterier
8. februar 2007
Først opslået (Anslået)
12. februar 2007
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
4. april 2024
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
3. april 2024
Sidst verificeret
1. februar 2024
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Neoplasmer efter histologisk type
- Neoplasmer
- Karcinom
- Neoplasmer, kirtel og epitel
- Adenocarcinom
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Enzymhæmmere
- Antirheumatiske midler
- Antineoplastiske midler
- Immunsuppressive midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, Alkylering
- Alkyleringsmidler
- Myeloablative agonister
- Antineoplastiske midler, fytogene
- Topoisomerase II-hæmmere
- Topoisomerasehæmmere
- Angiogenese-hæmmere
- Angiogenesemodulerende midler
- Vækststoffer
- Væksthæmmere
- Antibiotika, antineoplastisk
- Cyclofosfamid
- Paclitaxel
- Antistoffer
- Immunoglobuliner
- Bevacizumab
- Albumin-bundet Paclitaxel
- Doxorubicin
- Liposomal doxorubicin
- Antistoffer, monoklonale
- Antineoplastiske midler, immunologiske
- Immunoglobulin G
- Endotelvækstfaktorer
Andre undersøgelses-id-numre
- NCI-2009-00561 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH-bevilling/kontrakt)
- U10CA021115 (U.S. NIH-bevilling/kontrakt)
- CDR0000528955
- E5103 (Anden identifikator: CTEP)
- ECOG-E5103
- 07-963
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
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M.D. Anderson Cancer CenterNational Cancer Institute (NCI)Aktiv, ikke rekrutterendeKlinisk trin III Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Klinisk trin IV Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Uoperabelt Gastroøsofageal Junction Adenocarcinoma | Lokalt avanceret Gastroøsofageal Junction Adenocarcinoma | Postneoadjuverende terapi Stage III Gastroøsofageal... og andre forholdForenede Stater
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Tianjin Medical University Cancer Institute and...Guangxi Medical University; Sun Yat-sen University; Chinese PLA General Hospital og andre samarbejdspartnereAfsluttetDen kliniske anvendelsesvejledning af Conebeam Breast CTKina
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ETOP IBCSG Partners FoundationAfsluttetBreast Cancer Invasive NosItalien
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Spanish Breast Cancer Research GroupHoffmann-La Roche; Roche Farma, S.AAfsluttetBreast Cancer Invasive NosSpanien
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City of Hope Medical CenterNational Cancer Institute (NCI)Aktiv, ikke rekrutterendeEsophageal Adenocarcinom | Esophageal pladecellekarcinom | Klinisk trin III Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Klinisk fase II Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Klinisk fase IVA Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Patologisk trin IIIA Gastroøsofageal... og andre forholdForenede Stater
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Ontario Clinical Oncology Group (OCOG)Afsluttet
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Pomeranian Medical University SzczecinMaria Sklodowska-Curie National Research Institute of Oncology; Regional...UkendtBRCA1 mutation | Breast Cancer Invasive NosPolen
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M.D. Anderson Cancer CenterRekrutteringKlinisk fase III gastrisk cancer AJCC v8 | Klinisk trin III Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Klinisk fase IV gastrisk cancer AJCC v8 | Klinisk trin IV Gastroøsofageal Junction Adenocarcinoma AJCC v8 | Metastatisk gastrisk adenocarcinom | Metastatisk Gastroøsofageal Junction Adenocarcinoma og andre forholdForenede Stater
Kliniske forsøg med Laboratoriebiomarkøranalyse
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Liao Jian AnRekrutteringHoved- og halskræftTaiwan
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Progenity, Inc.AfsluttetDowns syndrom | Aneuploidi | DiGeorges syndrom | Turners syndrom | Klinefelters syndrom | Kromosom sletning | Edwards syndrom | Patau syndromForenede Stater
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Fondation LenvalTrukket tilbage
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IRCCS Eugenio MedeaRekrutteringAutismespektrumforstyrrelse | Tidlig indsatsItalien
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Oregon Health and Science University4DMedicalTilmelding efter invitationLungesygdomme | KOL | Luftvejssygdom | DyspnøForenede Stater
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IRCCS Eugenio MedeaRekrutteringCerebral Parese | Erhvervet hjerneskadeItalien
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Modarres HospitalAfsluttetKomplikationer | Billedstyret biopsi | Nyre GlomerulusIran, Islamisk Republik
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Healthy.io Ltd.Afsluttet
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Medwave Estudios LimitadaAsociación Chilena de SeguridadUkendtErhvervsmæssig eksponering | Muskuloskeletal sygdomChile
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Alcon ResearchAfsluttet