Denne side blev automatisk oversat, og nøjagtigheden af ​​oversættelsen er ikke garanteret. Der henvises til engelsk version for en kildetekst.

Sunitinib Malate som vedligeholdelsesterapi til behandling af patienter med trin III eller trin IV ikke-småcellet lungekræft tidligere behandlet med kombinationskemoterapi

29. maj 2026 opdateret af: National Cancer Institute (NCI)

Randomiseret, fase III, dobbeltblindet placebokontrolleret forsøg med Sunitinib (NSC #736511) som vedligeholdelsesterapi hos ikke-progressive patienter efter en indledende fire cyklusser af platinbaseret kombinationskemoterapi i avanceret, trin IIIB/IV ikke-småcellet lunge Kræft

Dette randomiserede fase III studie undersøger sunitinib malat for at se, hvor godt det virker, når det gives som vedligeholdelsesterapi (hvilket betyder, at det er godkendt til behandling efter kemoterapi) hos patienter med stadium IIIB-IV ikke-småcellet lungekræft, som har reageret på tidligere behandling med kombination kemoterapi. Sunitinibmalat kan stoppe væksten af ​​tumorceller ved at blokere nogle af de enzymer, der er nødvendige for cellevækst, og ved at blokere væksten af ​​nye blodkar, der er nødvendige for tumorvækst. Det vides endnu ikke, om sunitinibmalat er effektivt til at hjælpe tumorer med at fortsætte med at skrumpe eller holde op med at vokse.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At evaluere effekten af ​​sunitinib (sunitinib malat) sammenlignet med placebo på progressionsfri overlevelse (PFS) hos fremskreden ikke-småcellet lungecancer (NSCLC), som har haft enten stabil eller responderende sygdom i løbet af deres første 4 cyklusser af platinbaseret terapi.

SEKUNDÆRE MÅL:

I. At evaluere toksiciteten af ​​sunitinib sammenlignet med placebo i vedligeholdelsesindstillingen.

II. For at evaluere den yderligere responsrate som et resultat af sunitinib i denne indstilling.

III. At vurdere effekten af ​​sunitinib på den samlede overlevelse sammenlignet med placebo-armen.

IV. For at vurdere virkningen af ​​sunitinib på at forsinke tiden til forringelse af livskvalitet og symptomprogression sammenlignet med placebo ved hjælp af European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30) og Lung Cancer Module ( LC13).

V. At vurdere vaskulær endothelial growth factor (VEGF) haplotyper i avanceret ikke-småcellet lungecancer og sunitinib vedligeholdelse.

OVERSIGT: Patienterne randomiseres til 1 ud af 2 behandlingsarme.

ARM I: Patienter får sunitinib malat oralt (PO) én gang dagligt (QD) på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM II: Patienter får placebo PO QD på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne op hver 3. måned i 1 år, hver 6. måned i 1 år og derefter periodisk i 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

210

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alabama
      • Anniston, Alabama, Forenede Stater, 36202
        • Northeast Alabama Regional Medical Center
      • Mobile, Alabama, Forenede Stater, 36608
        • Providence Hospital
    • Arkansas
      • Little Rock, Arkansas, Forenede Stater, 72205
        • University of Arkansas for Medical Sciences
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Veteran's Administration Medical Center
    • California
      • Anaheim, California, Forenede Stater, 92806
        • Kaiser Permanente-Anaheim
      • Arroyo Grande, California, Forenede Stater, 93420
        • PCR Oncology
      • Baldwin Park, California, Forenede Stater, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Forenede Stater, 90706
        • Kaiser Permanente-Bellflower
      • Castro Valley, California, Forenede Stater, 94546
        • Eden Hospital Medical Center
      • Castro Valley, California, Forenede Stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forenede Stater, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Chico, California, Forenede Stater, 95928
        • Feather River Cancer Center
      • Emeryville, California, Forenede Stater, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Forenede Stater, 94608
        • Epic Care Partners in Cancer Care
      • Fontana, California, Forenede Stater, 92335
        • Kaiser Permanente-Fontana
      • Fremont, California, Forenede Stater, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Permanente - Harbor City
      • Irvine, California, Forenede Stater, 92618
        • Kaiser Permanente-Irvine
      • Long Beach, California, Forenede Stater, 90806
        • Long Beach Memorial Medical Center-Todd Cancer Institute
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forenede Stater, 90034
        • Kaiser Permanente-Cadillac
      • Martinez, California, Forenede Stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, Forenede Stater, 95355
        • Memorial Medical Center
      • Mountain View, California, Forenede Stater, 94040
        • El Camino Hospital
      • Mountain View, California, Forenede Stater, 94040
        • Palo Alto Medical Foundation-Camino Division
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forenede Stater, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, Forenede Stater, 94602
        • Highland General Hospital
      • Oakland, California, Forenede Stater, 94609
        • Tom K Lee Inc
      • Oakland, California, Forenede Stater, 94609
        • Bay Area Tumor Institute
      • Palo Alto, California, Forenede Stater, 94301
        • Palo Alto Medical Foundation Health Care
      • Panorama City, California, Forenede Stater, 91402
        • Kaiser Permanente - Panorama City
      • Pleasanton, California, Forenede Stater, 94588
        • Valley Care Health System - Pleasanton
      • Pleasanton, California, Forenede Stater, 94588
        • Valley Medical Oncology Consultants
      • Riverside, California, Forenede Stater, 92505
        • Kaiser Permanente-Riverside
      • San Diego, California, Forenede Stater, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, Forenede Stater, 92134
        • Naval Medical Center -San Diego
      • San Diego, California, Forenede Stater, 92108
        • Kaiser Permanente-San Diego Mission
      • San Marcos, California, Forenede Stater, 92078
        • Kaiser Permanente-San Marcos
      • San Pablo, California, Forenede Stater, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • St. Helena, California, Forenede Stater, 94574
        • Saint Helena Hospital
      • Sunnyvale, California, Forenede Stater, 94086
        • Palo Alto Medical Foundation-Sunnyvale
      • Vacaville, California, Forenede Stater, 95687
        • Northbay Cancer Center
      • Woodland Hills, California, Forenede Stater, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Poudre Valley Hospital
    • Connecticut
      • Hartford, Connecticut, Forenede Stater, 06102
        • Hartford Hospital
      • Middletown, Connecticut, Forenede Stater, 06457
        • Middlesex Hospital
      • New Britain, Connecticut, Forenede Stater, 06050
        • The Hospital of Central Connecticut
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Seaford, Delaware, Forenede Stater, 19973
        • Nanticoke Memorial Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, Forenede Stater, 20007
        • MedStar Georgetown University Hospital
      • Washington D.C., District of Columbia, Forenede Stater, 20016
        • Sibley Memorial Hospital
      • Washington D.C., District of Columbia, Forenede Stater, 20060
        • Howard University Hospital
    • Florida
      • Boca Raton, Florida, Forenede Stater, 33486
        • Boca Raton Comprehensive Cancer Center
      • Daytona Beach, Florida, Forenede Stater, 32117
        • Florida Hospital Memorial Medical Center
      • Fort Lauderdale, Florida, Forenede Stater, 33316
        • Broward Health Medical Center
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Holy Cross Hospital
      • Jupiter, Florida, Forenede Stater, 33458
        • Jupiter Medical Center
      • Miami Beach, Florida, Forenede Stater, 33140
        • Mount Sinai Medical Center
      • Orlando, Florida, Forenede Stater, 32803
        • AdventHealth Orlando
    • Georgia
      • Columbus, Georgia, Forenede Stater, 31904
        • John B Amos Cancer Center
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Savannah, Georgia, Forenede Stater, 31404
        • Memorial Health University Medical Center
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Saint Anthony's Health
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush - Copley Medical Center
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forenede Stater, 60625
        • Swedish Covenant Hospital
      • Chicago, Illinois, Forenede Stater, 60611
        • Hematology and Oncology Associates
      • Chicago, Illinois, Forenede Stater, 60631
        • Presence Resurrection Medical Center
      • Chicago, Illinois, Forenede Stater, 60640
        • Weiss Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60657
        • Advocate Illinois Masonic Medical Center
      • Chicago, Illinois, Forenede Stater, 60657
        • Presence Saint Joseph Hospital-Chicago
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Elk Grove Village, Illinois, Forenede Stater, 60007
        • AMITA Health Alexian Brothers Medical Center
      • Elmhurst, Illinois, Forenede Stater, 60126
        • Elmhurst Memorial Hospital
      • Evanston, Illinois, Forenede Stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Evanston, Illinois, Forenede Stater, 60202
        • Saint Francis Hospital
      • Kankakee, Illinois, Forenede Stater, 60901
        • Presence Saint Mary's Hospital
      • La Grange, Illinois, Forenede Stater, 60525
        • AMITA Health Adventist Medical Center
      • Moline, Illinois, Forenede Stater, 61265
        • Garneau, Stewart C MD (UIA Investigator)
      • Moline, Illinois, Forenede Stater, 61265
        • Porubcin, Michael MD (UIA Investigator)
      • Moline, Illinois, Forenede Stater, 61265
        • Spector, David MD (UIA Investigator)
      • Moline, Illinois, Forenede Stater, 61265
        • Trinity Medical Center
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Good Samaritan Regional Health Center
      • Naperville, Illinois, Forenede Stater, 60540
        • Edward Hospital/Cancer Center
      • Naperville, Illinois, Forenede Stater, 60540
        • AMG Oncology - Naperville
      • River Forest, Illinois, Forenede Stater, 60305
        • West Suburban Medical Center
      • Rockford, Illinois, Forenede Stater, 61108
        • OSF Saint Anthony Medical Center
      • Rockford, Illinois, Forenede Stater, 61104
        • Swedish American Hospital
      • Skokie, Illinois, Forenede Stater, 60076
        • Hematology Oncology Associates of Illinois - Skokie
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
    • Indiana
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forenede Stater, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, Forenede Stater, 46514-2098
        • Elkhart Clinic
      • Fort Wayne, Indiana, Forenede Stater, 46845
        • Fort Wayne Medical Oncology and Hematology Inc-Parkview
      • Indianapolis, Indiana, Forenede Stater, 46260
        • Saint Vincent Hospital and Health Care Center
      • Kokomo, Indiana, Forenede Stater, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Forenede Stater, 46350
        • IU Health La Porte Hospital
      • Michigan City, Indiana, Forenede Stater, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Cancer Care Partners LLC
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Plymouth, Indiana, Forenede Stater, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • Michiana Hematology Oncology PC-South Bend
      • South Bend, Indiana, Forenede Stater, 46628
        • Northern Indiana Cancer Research Consortium
      • South Bend, Indiana, Forenede Stater, 46617
        • South Bend Clinic
      • Westville, Indiana, Forenede Stater, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC - Ames
      • Bettendorf, Iowa, Forenede Stater, 52722
        • Constantinou, Costas L MD (UIA Investigator)
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa-Wide Oncology Research Coalition NCORP
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Des Moines, Iowa, Forenede Stater, 50307
        • Mercy Capitol
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Iowa City, Iowa, Forenede Stater, 52246
        • Iowa City VA Healthcare System
      • Mason City, Iowa, Forenede Stater, 50401
        • Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, Forenede Stater, 52501
        • Ottumwa Regional Health Center
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, Forenede Stater, 51102
        • Mercy Medical Center-Sioux City
      • Sioux City, Iowa, Forenede Stater, 51104
        • Saint Luke's Regional Medical Center
      • Waterloo, Iowa, Forenede Stater, 50701
        • Cedar Valley Medical Specialists
    • Kansas
      • Anthony, Kansas, Forenede Stater, 67003
        • Hospital District Sixth of Harper County
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, Forenede Stater, 66112
        • Providence Medical Center
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67905
        • Cancer Center of Kansas-Liberal
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66213
        • Saint Luke's South Hospital
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Prairie Village, Kansas, Forenede Stater, 66208
        • Kansas City NCI Community Oncology Research Program
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Shawnee Mission, Kansas, Forenede Stater, 66204
        • Shawnee Mission Medical Center-KCCC
      • Topeka, Kansas, Forenede Stater, 66606
        • Cotton O'Neil Cancer Center / Stormont Vail Health
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Louisville, Kentucky, Forenede Stater, 40215
        • Doctors Carrol, Sheth, Raghavan
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Mary Bird Perkins Cancer Center
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, Forenede Stater, 70806
        • Baton Rouge General Medical Center
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Hematology/Oncology Clinic LLP
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Tulane University Health Sciences Center
      • New Orleans, Louisiana, Forenede Stater, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Louisiana State University Health Science Center
      • New Orleans, Louisiana, Forenede Stater, 70115
        • Ochsner Baptist Medical Center
    • Maine
      • Bangor, Maine, Forenede Stater, 04401
        • Eastern Maine Medical Center
      • Lewiston, Maine, Forenede Stater, 04240
        • Saint Mary's Regional Medical Center
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21237
        • MedStar Franklin Square Medical Center/Weinberg Cancer Institute
      • Baltimore, Maryland, Forenede Stater, 21201
        • University of Maryland/Greenebaum Cancer Center
      • Baltimore, Maryland, Forenede Stater, 21225
        • MedStar Harbor Hospital
      • Baltimore, Maryland, Forenede Stater, 21201
        • Veterans Administration Medical Center-Baltimore
      • Bel Air, Maryland, Forenede Stater, 21014
        • UM Upper Chesapeake Medical Center
      • Bethesda, Maryland, Forenede Stater, 20889-5600
        • Walter Reed National Military Medical Center
      • Elkton, Maryland, Forenede Stater, 21921
        • Union Hospital of Cecil County
    • Massachusetts
      • Attleboro, Massachusetts, Forenede Stater, 02703
        • Sturdy Memorial Hospital
      • Beverly, Massachusetts, Forenede Stater, 01915
        • Beverly Hospital
      • Gloucester, Massachusetts, Forenede Stater, 01930
        • Addison Gilbert Hospital
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Bixby Medical Center
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center
      • Escanaba, Michigan, Forenede Stater, 49829
        • Green Bay Oncology - Escanaba
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Green Bay Oncology - Iron Mountain
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49048
        • Borgess Medical Center
      • Marquette, Michigan, Forenede Stater, 49855
        • UP Health System Marquette
      • Monroe, Michigan, Forenede Stater, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Niles, Michigan, Forenede Stater, 49120
        • Lakeland Hospital Niles
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Medical Center Saint Joseph
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Marie Yeager Cancer Center
      • Southfield, Michigan, Forenede Stater, 48075
        • Ascension Providence Hospitals - Southfield
    • Minnesota
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • Saint Luke's Hospital of Duluth
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, Forenede Stater, 55350
        • Hutchinson Area Health Care
      • Mankato, Minnesota, Forenede Stater, 56001
        • Mayo Clinic Health Systems-Mankato
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55417
        • Minneapolis VA Medical Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Gulfport, Mississippi, Forenede Stater, 39502
        • Gulfport Memorial Hospital
      • Hattiesburg, Mississippi, Forenede Stater, 39404
        • Forrest General Hospital / Cancer Center
      • Pascagoula, Mississippi, Forenede Stater, 39581
        • Singing River Hospital
    • Missouri
      • Bolivar, Missouri, Forenede Stater, 65613
        • Central Care Cancer Center - Bolivar
      • Branson, Missouri, Forenede Stater, 65616
        • Cox Cancer Center Branson
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Cape Girardeau, Missouri, Forenede Stater, 63701
        • Southeast Missouri Hospital
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Saint Luke's Hospital
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Columbia, Missouri, Forenede Stater, 65201
        • Veterans Administration
      • Independence, Missouri, Forenede Stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Capital Region Southwest Campus
      • Joplin, Missouri, Forenede Stater, 64804
        • Freeman Health System
      • Joplin, Missouri, Forenede Stater, 64804
        • Mercy Hospital Joplin
      • Kansas City, Missouri, Forenede Stater, 64116
        • North Kansas City Hospital
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Forenede Stater, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Kansas City, Missouri, Forenede Stater, 64114
        • Saint Joseph Health Center
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forenede Stater, 64068
        • Liberty Radiation Oncology Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Delbert Day Cancer Institute at PCRMC
      • Rolla, Missouri, Forenede Stater, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Saint Joseph Oncology Inc
      • Saint Joseph, Missouri, Forenede Stater, 64507
        • Heartland Regional Medical Center
      • Springfield, Missouri, Forenede Stater, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Forenede Stater, 63141
        • Comprehensive Cancer Care PC
      • St Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Forenede Stater, 63141
        • Saint Louis-Cape Girardeau CCOP
      • St Louis, Missouri, Forenede Stater, 63141
        • Center for Cancer Care and Research
      • St Louis, Missouri, Forenede Stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59102
        • Montana Cancer Consortium NCORP
      • Billings, Montana, Forenede Stater, 59101
        • Northern Rockies Radiation Oncology Center
      • Billings, Montana, Forenede Stater, 59102
        • Saint Vincent Frontier Cancer Center
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Great Falls, Montana, Forenede Stater, 59405
        • Berdeaux, Donald MD (UIA Investigator)
      • Havre, Montana, Forenede Stater, 59501
        • Northern Montana Hospital
      • Helena, Montana, Forenede Stater, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Kalispell, Montana, Forenede Stater, 59901
        • Glacier Oncology PLLC
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Medical Oncology
      • Missoula, Montana, Forenede Stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59804
        • Guardian Oncology and Center for Wellness
      • Missoula, Montana, Forenede Stater, 59802
        • Montana Cancer Specialists
    • Nebraska
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Nebraska Cancer Research Center
      • North Platte, Nebraska, Forenede Stater, 69101
        • Great Plains Health Callahan Cancer Center
      • Omaha, Nebraska, Forenede Stater, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, Forenede Stater, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Forenede Stater, 68131
        • Creighton University Medical Center
      • Omaha, Nebraska, Forenede Stater, 68106
        • Missouri Valley Cancer Consortium
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Nevada Cancer Research Foundation CCOP
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology Hematology PA-Concord
      • Exeter, New Hampshire, Forenede Stater, 03833
        • Exeter Hospital
      • Hooksett, New Hampshire, Forenede Stater, 03106
        • New Hampshire Oncology Hematology PA-Hooksett
      • Laconia, New Hampshire, Forenede Stater, 03246
        • LRGHealthcare-Lakes Region General Hospital
      • Manchester, New Hampshire, Forenede Stater, 03102
        • Norris Cotton Cancer Center-Manchester
    • New Jersey
      • Camden, New Jersey, Forenede Stater, 08103
        • Cooper Hospital University Medical Center
      • East Orange, New Jersey, Forenede Stater, 07018-1095
        • Veterans Adminstration New Jersey Health Care System
      • Newark, New Jersey, Forenede Stater, 07112
        • Newark Beth Israel Medical Center
      • Toms River, New Jersey, Forenede Stater, 08755
        • Community Medical Center
      • Vineland, New Jersey, Forenede Stater, 08360
        • Inspira Medical Center Vineland
    • New York
      • Cooperstown, New York, Forenede Stater, 13326
        • Mary Imogene Bassett Hospital
      • East Syracuse, New York, Forenede Stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Elmira, New York, Forenede Stater, 14905
        • Arnot Ogden Medical Center/Falck Cancer Center
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • Middletown, New York, Forenede Stater, 10940
        • Orange Regional Medical Center
      • New York, New York, Forenede Stater, 10065
        • NYP/Weill Cornell Medical Center
      • Rochester, New York, Forenede Stater, 14642
        • University of Rochester
      • Rochester, New York, Forenede Stater, 14620
        • Highland Hospital
      • Rochester, New York, Forenede Stater, 14623
        • Interlakes Foundation Inc-Rochester
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
      • Syracuse, New York, Forenede Stater, 13210
        • Syracuse Veterans Administration Medical Center
    • North Carolina
      • Burlington, North Carolina, Forenede Stater, 27215
        • Cone Health Cancer Center at Alamance Regional
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • UNC Lineberger Comprehensive Cancer Center
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke University Medical Center
      • Durham, North Carolina, Forenede Stater, 27705
        • Durham VA Medical Center
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Memorial Hospital
      • Greenville, North Carolina, Forenede Stater, 27834
        • East Carolina University
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Margaret R Pardee Memorial Hospital
      • Kinston, North Carolina, Forenede Stater, 28501
        • Vidant Oncology-Kinston
      • Lumberton, North Carolina, Forenede Stater, 28358
        • Southeastern Regional Medical Center
      • Oxford, North Carolina, Forenede Stater, 27565
        • Granville Medical Center
      • Raleigh, North Carolina, Forenede Stater, 27609
        • Duke Raleigh Hospital
      • Rocky Mount, North Carolina, Forenede Stater, 27804
        • Nash General Hospital
      • Roxboro, North Carolina, Forenede Stater, 27573
        • Person Memorial Hospital
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Wake Forest University Health Sciences
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Mid Dakota Clinic
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Saint Alexius Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • Cleveland Clinic Akron General
      • Bellefontaine, Ohio, Forenede Stater, 43311
        • Mary Rutan Hospital
      • Belpre, Ohio, Forenede Stater, 45714
        • Strecker Cancer Center-Belpre
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Canton, Ohio, Forenede Stater, 44708
        • Mercy Medical Center
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Medical Center
      • Clyde, Ohio, Forenede Stater, 43410
        • North Coast Cancer Care-Clyde
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43213
        • Mount Carmel East Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Forenede Stater, 43215
        • Columbus NCI Community Oncology Research Program
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Elyria, Ohio, Forenede Stater, 44035
        • Mercy Cancer Center-Elyria
      • Elyria, Ohio, Forenede Stater, 44035
        • Hematology Oncology Center Incorporated
      • Lancaster, Ohio, Forenede Stater, 43130
        • Fairfield Medical Center
      • Lima, Ohio, Forenede Stater, 45801
        • Saint Rita's Medical Center
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, Forenede Stater, 45750
        • Marietta Memorial Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Maumee, Ohio, Forenede Stater, 43537
        • Saint Luke's Hospital
      • Mount Vernon, Ohio, Forenede Stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Hospital
      • Norwalk, Ohio, Forenede Stater, 44857
        • Fisher-Titus Medical Center
      • Oregon, Ohio, Forenede Stater, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Southern Ohio Medical Center
      • Sandusky, Ohio, Forenede Stater, 44870
        • North Coast Cancer Care
      • Springfield, Ohio, Forenede Stater, 45505
        • Springfield Regional Medical Center
      • Steubenville, Ohio, Forenede Stater, 43952
        • Trinity's Tony Teramana Cancer Center
      • Sylvania, Ohio, Forenede Stater, 43560
        • ProMedica Flower Hospital
      • Tiffin, Ohio, Forenede Stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forenede Stater, 43608
        • Saint Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forenede Stater, 43614
        • University of Toledo
      • Toledo, Ohio, Forenede Stater, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Toledo, Ohio, Forenede Stater, 43606
        • The Toledo Hospital/Toledo Children's Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Saint Anne Hospital
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Saint Ann's Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Lawton, Oklahoma, Forenede Stater, 73505
        • Cancer Centers of Southwest Oklahoma Research
      • Norman, Oklahoma, Forenede Stater, 73071
        • Cancer Care Associates-Norman
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Hospital Oklahoma City
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Physicians of Oklahoma-Lakeside
    • Oregon
      • Clackamas, Oregon, Forenede Stater, 97015
        • Clackamas Radiation Oncology Center
      • Coos Bay, Oregon, Forenede Stater, 97420
        • Bay Area Hospital
      • Milwaukie, Oregon, Forenede Stater, 97222
        • Providence Milwaukie Hospital
      • Newberg, Oregon, Forenede Stater, 97132
        • Providence Newberg Medical Center
      • Oregon City, Oregon, Forenede Stater, 97045
        • Providence Willamette Falls Medical Center
      • Portland, Oregon, Forenede Stater, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Forenede Stater, 97225
        • Providence Saint Vincent Medical Center
      • Salem, Oregon, Forenede Stater, 97301
        • Salem Hospital
      • The Dalles, Oregon, Forenede Stater, 97058
        • Mid-Columbia Medical Center/Celilo Cancer Center
    • Pennsylvania
      • Butler, Pennsylvania, Forenede Stater, 16001
        • Butler Memorial Hospital
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • Easton, Pennsylvania, Forenede Stater, 18042
        • Easton Hospital
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Philadelphia, Pennsylvania, Forenede Stater, 19140
        • Temple University Hospital
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • University of Pittsburgh Cancer Institute (UPCI)
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Scranton Hematology Oncology
      • Scranton, Pennsylvania, Forenede Stater, 18501
        • Mercy Hospital
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group
      • West Chester, Pennsylvania, Forenede Stater, 19380
        • Chester County Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
    • Rhode Island
      • Pawtucket, Rhode Island, Forenede Stater, 02860
        • Memorial Hospital of Rhode Island
      • Providence, Rhode Island, Forenede Stater, 02903
        • Rhode Island Hospital
      • Providence, Rhode Island, Forenede Stater, 02906
        • Miriam Hospital
    • South Carolina
      • Beaufort, South Carolina, Forenede Stater, 29902
        • Beaufort Memorial Hospital
      • Charleston, South Carolina, Forenede Stater, 29401
        • Roper Hospital
      • Easley, South Carolina, Forenede Stater, 29640
        • Greenville Health System Cancer Institute-Easley
      • Florence, South Carolina, Forenede Stater, 29506
        • McLeod Regional Medical Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Greenville Health System Cancer Institute-Andrews
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Faris
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Memorial Hospital
      • Greenville, South Carolina, Forenede Stater, 29615
        • Greenville Health System Cancer Institute-Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Butternut
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29650
        • Greenville Health System Cancer Institute-Greer
      • Myrtle Beach, South Carolina, Forenede Stater, 29572
        • Coastal Cancer Center-Myrtle Beach
      • Seneca, South Carolina, Forenede Stater, 29672
        • Greenville Health System Cancer Institute-Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Greenville Health System Cancer Institute-Spartanburg
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
      • Sioux Falls, South Dakota, Forenede Stater, 57105
        • Medical X-Ray Center
    • Tennessee
      • Nashville, Tennessee, Forenede Stater, 37208
        • Meharry Medical College
      • Nashville, Tennessee, Forenede Stater, 37203
        • Nashville Oncology Associates PC
    • Texas
      • Dallas, Texas, Forenede Stater, 75216
        • Dallas VA Medical Center
      • Houston, Texas, Forenede Stater, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • Michael E DeBakey VA Medical Center
      • Houston, Texas, Forenede Stater, 77030
        • The Methodist Hospital System
      • Houston, Texas, Forenede Stater, 77030
        • Ben Taub General Hospital
      • Houston, Texas, Forenede Stater, 77030
        • Baylor Saint Luke's Medical Center
      • Temple, Texas, Forenede Stater, 76508
        • Scott and White Memorial Hospital
    • Vermont
      • Bennington, Vermont, Forenede Stater, 05201
        • Southwestern Vermont Medical Center
      • Berlin Corners, Vermont, Forenede Stater, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Forenede Stater, 05405
        • University of Vermont and State Agricultural College
    • Virginia
      • Charlottesville, Virginia, Forenede Stater, 22908
        • University of Virginia Cancer Center
      • Danville, Virginia, Forenede Stater, 24541
        • Danville Regional Medical Center
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Fredericksburg Oncology Inc
      • Lynchburg, Virginia, Forenede Stater, 24501
        • Centra Lynchburg Hematology-Oncology Clinic Inc
      • Martinsville, Virginia, Forenede Stater, 24115
        • Sovah Health Martinsville
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
      • Richmond, Virginia, Forenede Stater, 23249
        • Hunter Holmes McGuire Veterans Administration Medical Center
      • South Hill, Virginia, Forenede Stater, 23970
        • VCU Community Memorial Health Center
    • Washington
      • Vancouver, Washington, Forenede Stater, 98664
        • PeaceHealth Southwest Medical Center
      • Yakima, Washington, Forenede Stater, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
    • West Virginia
      • Huntington, West Virginia, Forenede Stater, 25701
        • Edwards Comprehensive Cancer Center
      • Huntington, West Virginia, Forenede Stater, 25702
        • Saint Mary's Medical Center
      • Morgantown, West Virginia, Forenede Stater, 26506
        • West Virginia University Healthcare
      • Parkersburg, West Virginia, Forenede Stater, 26101
        • Camden Clark Medical Center
      • Wheeling, West Virginia, Forenede Stater, 26003
        • Wheeling Hospital/Schiffler Cancer Center
    • Wisconsin
      • Burlington, Wisconsin, Forenede Stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Fond du Lac, Wisconsin, Forenede Stater, 54935
        • Saint Agnes Hospital/Agnesian Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology Limited at Saint Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Janesville, Wisconsin, Forenede Stater, 53547
        • Mercy Health System
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Mayo Clinic Health System-Franciscan Healthcare
      • Madison, Wisconsin, Forenede Stater, 53717
        • Dean Hematology and Oncology Clinic
      • Manitowoc, Wisconsin, Forenede Stater, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Bay Area Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center-Marshfield
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center
      • Mequon, Wisconsin, Forenede Stater, 53097
        • Columbia Saint Mary's Hospital - Ozaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53211
        • Columbia Saint Mary's Water Tower Medical Commons
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Saint Vincent Hospital Cancer Center at Oconto Falls
      • Racine, Wisconsin, Forenede Stater, 53405
        • Wheaton Franciscan Cancer Care - All Saints
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Ascension Saint Mary's Hospital
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • HSHS Saint Nicholas Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Ascension Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology - Sturgeon Bay
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • ProHealth Waukesha Memorial Hospital
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic - Weston Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Aspirus UW Cancer Center
    • Wyoming
      • Casper, Wyoming, Forenede Stater, 82609
        • Rocky Mountain Oncology
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Histologisk eller cytologisk dokumentation af primær ikke-småcellet lungekræft
  • Stadie IIIB eller IV sygdomspatienter, som ikke er kandidater til kombineret modalitetsterapi (kemoradioterapi)
  • Ingen tegn på symptomatiske eller ubehandlede hjernemetastaser, rygmarvskompression eller karcinomatøs meningitis; Patienter med metastaser i centralnervesystemet (CNS) skal være asymptomatiske, skal have modtaget endelig behandling (>= 6 uger siden resektion eller >= 2 uger siden strålebehandling) for hjernemetastaser og være fri for steroider eller på en stabil dosis i 2 uger før til registrering
  • Ingen kavitære læsioner
  • Patienter skal have modtaget ét kemoterapiregime for stadium IIIB eller IV NSCLC; kuren skal omfatte fire cyklusser af platin-baseret dublet kemoterapi med eller uden bevacizumab (bevacizumab må ikke gives ud over den fjerde cyklus af kemoterapi); patienter skal have opnået et fuldstændigt respons, delvist respons eller stabil sygdom på førstelinje-kemoterapi og ikke have tegn på sygdomsprogression; patienter vil blive registreret 3-5 uger efter dag 1 i cyklus 4 af tidligere behandling
  • Ingen forudgående adjuverende kemoterapi for fase I-III resekteret NSCLC eller kombineret modalitetsbehandling for stadium III NSCLC
  • Ingen anden primær terapi (herunder eksperimentel terapi) for NSCLC; palliativ strålebehandling skal være afsluttet mindst en uge før planlagt start af protokolbehandling

  • Patienter skal have målbar eller ikke-målbar sygdom

    • Målbar sygdom: læsioner, der kan måles nøjagtigt i mindst én dimension (længste diameter, der skal registreres) som >= 2 cm med konventionelle teknikker eller som >= 1 cm med spiral computertomografi (CT) scanning

    • Ikke-målbar sygdom: alle andre læsioner, inklusive små læsioner (længste diameter < 20 mm med konventionelle teknikker eller < 10 mm med spiral CT-scanning) og virkelig ikke-målbare læsioner; læsioner, der anses for ikke-målbare, omfatter følgende:

      • Knoglelæsioner
      • Leptomeningeal sygdom
      • Ascites
      • Pleural/pericardial effusion
      • Lymphangitis cutis/pulmonis
      • Abdominale masser, der ikke er bekræftet og efterfulgt af billedbehandlingsteknikker
      • Cystiske læsioner
  • Eastern Cooperative Oncology Group (ECOG) præstationsstatus 0 eller 1
  • Ikke-gravide og ikke-ammende
  • Ingen igangværende hjerterytmeforstyrrelser, atrieflimren eller historie med korrigeret QT (QTc)-interval >= 500 msek (inden for 2 år før registrering); brug af midler med proarytmisk potentiale (f.eks. quinidin, procainamid, disopyramid, sotalol, probucol, haloperidol, risperidon, indapamid, flecainid) anbefales ikke under protokolbehandling

  • Patienter med klasse I New York Heart Association (NYHA) hjertesvigt er kvalificerede; patienter med en historie med klasse II NYHA hjertesvigt er kvalificerede, forudsat at de opfylder mindst et af følgende kriterier:

    • Patienter med en historie med hjertesvigt klasse II, som er asymptomatiske under behandling
    • Patienter med tidligere antracyklineksponering
    • Patienter, der har modtaget central thoraxbestråling, der omfattede hjertet i strålebehandlingsporten
  • Patienter med en historie med klasse III eller IV NYHA hjertesvigt inden for 12 måneder før registrering er ikke kvalificerede
  • Ingen myokardieinfarkt, svær/ustabil angina, koronar/perifer arterie bypass graft eller stenting, cerebrovaskulær ulykke eller forbigående iskæmisk anfald inden for det sidste år
  • Patienter med hypertension, der ikke kan kontrolleres med medicin (> 150/100 mmHg trods optimal medicinsk behandling) er ikke kvalificerede
  • Patienter, som kræver brug af terapeutisk antikoagulering for tromboembolisk sygdom, er ikke kvalificerede; Bemærk: lave doser af coumadin (op til 2 mg dagligt) er tilladt til profylakse af trombose
  • Ingen historie med venøs trombose, lungeemboli eller hyperkoagulopati syndrom
  • Ingen historie med pulmonal blødning, blødende diatese eller tegn på hæmotyse; patienter med blodfarvet eller blodstribet opspyt vil få tilladelse til undersøgelse, hvis hæmoptysen beløber sig til mindre end 5 ml blod pr. episode og mindre end 10 ml blod pr. 24-timers periode ifølge investigators bedste skøn
  • Patienter med en historie med hypothyroidisme er berettigede, forudsat at de i øjeblikket er euthyroid
  • Ingen af ​​følgende inden for 28 dage efter påbegyndelse af behandlingen: abdominal fistel, mave-tarmperforation, intraabdominal absces, alvorlige eller ikke-helende sår, sår eller knoglebrud
  • Følgende hæmmere af cytokrom P450 3A4 (CYP3A4) er forbudt inden for 7 dage før påbegyndelse af og under behandling med sunitinib: azol-antimykotika (ketoconazol, itraconazol), diltiazem, clarithromycin, erythromycin, verapamil, delavirdin og human immundefekt-virus. (indinavir, saquinavir, ritonavir, atazanavir, nelfinavir); følgende inducere af CYP3A4 er forbudt inden for 12 dage før påbegyndelse af og under behandling med sunitinib: rifampin, rifabutin, carbamazepin, phenobarbital, phenytoin, perikon, efavirenz, tipranavir; andre hæmmere og inducere af CYP3A4 kan anvendes om nødvendigt, men deres brug frarådes
  • Patienter, der ikke er i stand til at tage oral medicin, er ikke berettigede
  • Granulocytter >= 1.500/mcl
  • Blodpladetal >= 100.000/mcl
  • Total bilirubin =< 1,5 x øvre normalgrænse (ULN)
  • Aspartataminotransferase (AST) og alaninaminotransferase (ALT)=< 2,5 x ULN; patienter med levermetastaser kan have ASAT og ALAT =< 5 x ULN; alle andre patienter vil have ASAT og ALAT =< 2,5 x ULN
  • Kreatinin =< 1,5 mg/dl

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Tredobbelt

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: Arm I (sunitinib malat)
Patienterne får sunitinibmalat 37,5 mg PO én gang dagligt på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Medicin: Sunitinib Malate
Givet PO
Andre navne:
  • Sutent
  • SU011248
  • SU11248
  • sunitinib
Placebo komparator: Arm II (placebo)
Patienterne får placebo 37,5 mg PO én gang dagligt på dag 1-21. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
Andet: Laboratoriebiomarkøranalyse
Korrelative undersøgelser
Andet: Livskvalitetsvurdering
Hjælpestudier
Andre navne:
  • Livskvalitetsvurdering
Andet: Placebo
Givet PO
Andre navne:
  • placebo terapi
  • PLCB
  • falsk terapi

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Progressionsfri overlevelse (PFS)
Tidsramme: Tid fra randomisering til sygdomsprogression og død af enhver årsag, alt efter hvad der kommer først (op til 5 år)
Progressionsfri overlevelse (PFS) blev defineret som tiden fra randomisering til sygdomsprogression eller død, alt efter hvad der indtræffer først. Median PFS med 95 % CI blev estimeret ved hjælp af Kaplan-Meier-metoden. Progression defineres som i det primære resultatmål.
Tid fra randomisering til sygdomsprogression og død af enhver årsag, alt efter hvad der kommer først (op til 5 år)

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Samlet overlevelse (OS)
Tidsramme: Tid fra randomisering til død (op til 5 år)
Samlet overlevelse (OS) er defineret som tiden fra patientens randomisering til døden uanset årsag. Median OS med 95 % CI blev estimeret ved hjælp af Kaplan-Meier-metoden.
Tid fra randomisering til død (op til 5 år)
Svarfrekvens (RR)
Tidsramme: Behandlingens varighed (op til 5 år)

Procentdelen af ​​patienter, der reagerer (helt eller delvist) på hvert kombinationsregime, vil blive estimeret. Respons blev defineret ved hjælp af responsevalueringskriterier i solide tumorer (RECIST) kriterier:

Komplet respons (CR): forsvinden af ​​alle mållæsioner; Delvis respons (PR) 30 % fald i summen af ​​mållæsioners længste diameter.
Behandlingens varighed (op til 5 år)
Procentdel af forringelse af QOL efter 3 måneder ved hjælp af EORTC QLQ-C30 Global Health Subscale
Tidsramme: Ved 3 måneder
Procentdelen af ​​patienter med et fald på mindst 10 % i EORTC-QLQ-C30 Global Health Subscale-score fra baseline til 3 måneder. Forskellen mellem grupperne vil blive testet ved hjælp af Fishers eksakte test.
Ved 3 måneder
Procentdel af forværring i symptomprogression efter 3 måneder ved brug af EORTC LC13 Dyspnø-underskalaen
Tidsramme: Ved 3 måneder
Procentdelen af ​​patienter med mindst 10 % fald i EORTC LC13 Dyspnø-underskala-score fra baseline til 3 måneder. Forskellen mellem grupperne vil blive testet ved hjælp af Fishers eksakte test.
Ved 3 måneder
Grad og type af toksicitet som vurderet af National Cancer Institute Common Terminology Criteria for Adverse Events Version 4.0
Tidsramme: Studiets varighed (op til 5 år)
Grad 3 eller 4 bivirkninger, som påvirkede mere end 5 % af deltagerne, er opsummeret efter arm.
Studiets varighed (op til 5 år)

Andre resultatmål

Resultatmål
Tidsramme
VEGF-niveauer og korrelation med kliniske resultater, inklusive RR, PFS og OS
Tidsramme: Op til 6 uger
Op til 6 uger

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: Mark A Socinski, Alliance for Clinical Trials in Oncology

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

15. juni 2008

Primær færdiggørelse (Faktiske)

8. november 2013

Studieafslutning (Faktiske)

28. maj 2015

Datoer for studieregistrering

Først indsendt

6. juni 2008

Først indsendt, der opfyldte QC-kriterier

6. juni 2008

Først opslået (Anslået)

9. juni 2008

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

23. juni 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

29. maj 2026

Sidst verificeret

1. maj 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NCI-2009-00469 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • U10CA180821 (U.S. NIH-bevilling/kontrakt)
  • U10CA031946 (U.S. NIH-bevilling/kontrakt)
  • CDR0000597649
  • CALGB 30607 (Anden identifikator: Alliance for Clinical Trials in Oncology)
  • CALGB-30607 (Anden identifikator: CTEP)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Abonner