MINIMALLY INVASIVE SURGERY in Total Knee Arthroplasty (MIS GEN II)
A Prospective (Non)-Randomized Controlled Multicenter Clinical Study Of the Genesis ii Total Knee System in Minimally Invasive Total Knee Arthroplasty
Overall study design:
A prospective, randomized, multi-center clinical studies comparing the minimal invasive and the standard surgical total knee replacement technique (control) using the Genesis II total knee system. The study will collect efficacy, safety and socio-economical data over 2 years. An additional 5 years follow-up interval is optional. The objectives (short-term follow-up) of the study are to:
- Assess whether the improvement in Pain and Range of motion per Knee Society scoring system and VAS score.
- Assess whether there are any differences between the surgical techniques as regards complication rate.
- Assess whether the hospital stay and the rehabilitation time (Straight leg raise, Active/passive ROM) of the patients differs between the two techniques.
- Assess the x-ray mechanical alignment between the two techniques.
Attempts will be made to assess whether the collected peri-operative data (including incision length, blood loss, wound appearance, hospital readmissions and operative time) differs between the two surgical techniques.
The primary objectives (mid-term follow-up) of the study are to:
- Improvement in Pain and Function per Knee Society Scoring system
- Number and Extent of Radiographic Lucencies >2mm
- Revision and knee-related adverse events
- Improvement in Quality-of-life via the VAS score
5 investigational sites will participate and enroll a total of approximately 250 patients over a 12 months period. Thus, each site will enroll 50 patients.
Studieoversigt
Status
Betingelser
Intervention / Behandling
Undersøgelsestype
Fase
- Fase 4
Kontakter og lokationer
Studiesteder
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Tübingen, Tyskland, 72076
- Orthopaedic Department, University Hospital
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Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Beskrivelse
Inclusion Criteria:
- require primary uni- or bilateral total knee arthroplasty; available for 2 year follow up; provide informed consent; is in stable health for cardio-pulmonary conditions.
Exclusion Criteria:
- inefficient femoral or tibial bone stock; BMI >35; fixed flexion deformity >15 degrees; knee flexion of <90 degrees; varus/valgus deformity >20 degrees; active local infection; conditions that would compromise the 2 years follow up.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
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Eksperimentel: Minimal Invasive Surgery,
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Aktiv komparator: Standard Surgical Technique
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Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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Pain and Range of Motion on the short term as efficacy measurements. Occurence of Adverse Events as safety measurements
Tidsramme: 1 year
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1 year
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Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
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Occurence of Adverse Events and Radiolucent lines > 2mm Range of motion on the mid term
Tidsramme: 2 years
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2 years
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Samarbejdspartnere og efterforskere
Sponsor
Datoer for undersøgelser
Studer store datoer
Studiestart
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Skøn)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Yderligere relevante MeSH-vilkår
Andre undersøgelses-id-numre
- MIS_GEN_II_6112003
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