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S1201: Kombinationskemo til patienter med avanceret eller metastatisk spiserørs-, gastrisk- eller gastroøsofageal Junction-kræft

25. oktober 2019 opdateret af: Southwest Oncology Group

Et randomiseret fase II-pilotstudie, der prospektivt evaluerer behandling for patienter baseret på ERCC1 (Excision Repair Cross-Complementing 1) for avanceret/metastatisk kræft i spiserør, gastrisk eller gastroøsofageal Junction (GEJ)

RATIONALE: Lægemidler, der bruges i kemoterapi, såsom oxaliplatin, leucovorin calcium, fluorouracil, irinotecan hydrochlorid og docetaxel, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne eller ved at stoppe dem i at dele sig. Kombination af mere end et lægemiddel kan dræbe flere tumorceller. Det vides endnu ikke, hvilket regime af kombinationskemoterapi, der er mere effektivt til behandling af tumorceller.

FORMÅL: Dette randomiserede fase II-forsøg undersøger, hvor godt oxaliplatin, leucovorin-calcium og fluorouracil virker sammenlignet med irinotecanhydrochlorid og docetaxel ved behandling af patienter med kræft i spiserøret, mavekræft eller kræft i gastroøsofageal junction.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

At vurdere progressionsfri overlevelse af high-excision reparation krydskomplementerende 1(ERCC1) patienter med fremskreden eller metastatisk cancer i spiserøret, maven eller gastroøsofageal junction (GEJ) behandlet med FOLFOX omfattende oxaliplatin, leucovorin calcium og fluorouracil sammenlignet med de behandlet med irinotecanhydrochlorid plus docetaxel.
At vurdere progressionsfri overlevelse af lav-ERCC1-patienter med fremskreden eller metastatisk cancer i spiserøret, maven eller GEJ behandlet med FOLFOX sammenlignet med dem, der blev behandlet med irinotecanhydrochlorid plus docetaxel.
At vurdere progressionsfri overlevelse af lav-ERCC1-patienter med fremskreden eller metastatisk cancer i spiserøret, maven eller GEJ behandlet med FOLFOX sammenlignet med patienter med høj ERCC1-behandlet med FOLFOX.
At vurdere den samlede overlevelse af og toksicitet i hver af de to behandlingsarme i denne gruppe af patienter.
At vurdere responssandsynligheden (bekræftet og ubekræftet, fuldstændig og delvis respons) i undergruppen af patienter med målbar sygdom i hver af de to behandlingsarme.
At undersøge, om der er tegn på interaktion mellem behandlingsarm og ERCC1-ekspression i denne gruppe patienter. (Undersøgende)
At banke væv og blod til fremtidige translationelle medicinske studier; a) At udforske forholdet mellem ERCC-1 og ERCC-2 single nucleotid polymorphism (SNP) genotyper med klinisk resultat hos disse patienter; og b) At udforske sammenhængen mellem kimlinjevariationer i disse SNP'er og ERCC-1 mRNA-ekspression hos disse patienter. (Undersøgende)

OVERSIGT: Dette er en multicenterundersøgelse. Patienterne er stratificeret efter ERCC1-ekspression (høj [≥ 1,7] vs. lav [< 1,7]) og sygdomssted (esophageal vs gastrisk/gastroøsofageal forbindelse). Patienterne randomiseres til 1 ud af 2 behandlingsarme.

Arm I (FOLFOX): Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV over 46-48 timer på dag 1-2. Kurser gentages hver 14. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.
Arm II: Patienterne får irinotecanhydrochlorid IV over 90 minutter og docetaxel IV over 30-60 minutter på dag 1 og 8. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Blod- og tumorvævsprøver kan indsamles til ERCC1-ekspressionsanalyse og fremtidige forskningsundersøgelser.

Efter afsluttet undersøgelsesbehandling følges patienterne hver 3. måned i op til 3 år.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

213

Fase

Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alabama
  - Mobile, Alabama, Forenede Stater, 36688
    - University of South Alabama Mitchell Cancer Institute
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
- California
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burlingame, California, Forenede Stater, 94010
    - Mills - Peninsula Hospitals
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles County-USC Medical Center
  - Los Angeles, California, Forenede Stater, 90033
    - University of Southern California/Norris Cancer Center
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Orange, California, Forenede Stater, 92868
    - University of California Medical Center At Irvine-Orange Campus
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Pleasanton, California, Forenede Stater, 94588
    - Valley Medical Oncology Consultants
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95817
    - University of California at Davis Cancer Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter General Hospital
  - San Francisco, California, Forenede Stater, 94118
    - California Pacific Medical Center-Pacific Campus
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - Sunnyvale, California, Forenede Stater, 94806
    - Palo Atlo Medical Foundation-Sunnyvale
  - Truckee, California, Forenede Stater, 96161
    - Tahoe Forest Cancer Center
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Exempla Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80907
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80224-2522
    - Colorado Cancer Research Program CCOP
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Comprehensive Cancer Care and Research Institute of Colorado LLC
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forenede Stater, 80401
    - Mountain Blue Cancer Care Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Greenwood Village, Colorado, Forenede Stater, 80111
    - Breast Cancer Care Consultants
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forenede Stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forenede Stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - Exempla Lutheran Medical Center
- Connecticut
  - Hartford, Connecticut, Forenede Stater, 06105
    - Saint Francis Hospital and Medical Center
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Newark, Delaware, Forenede Stater, 19713
    - Christiana Gynecologic Oncology LLC
  - Newark, Delaware, Forenede Stater, 19713
    - Regional Hematology and Oncology PA
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - Nanticoke Memorial Hospital
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- Florida
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward Health Medical Center
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Healthcare System - Joe DiMaggio Children's Hospital
  - Jupiter, Florida, Forenede Stater, 33458
    - Jupiter Medical Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32803
    - Florida Hospital
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - Memorial Hospital West
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial University Medical Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Oncare Hawaii Inc-Pali Momi
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Oncare Hawaii Inc-POB II
  - Honolulu, Hawaii, Forenede Stater, 96817-3169
    - OnCare Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Oncare Hawaii Inc-Kuakini
  - Kailua, Hawaii, Forenede Stater, 96734
    - Castle Medical Center
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Lewiston, Idaho, Forenede Stater, 83501
    - Saint Joseph Regional Medical Center
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meredian
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Cancer Center
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Health
  - Bloomington, Illinois, Forenede Stater, 61701
    - Saint Joseph Medical Center
  - Bloomington, Illinois, Forenede Stater, 61701
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Canton, Illinois, Forenede Stater, 61520
    - Graham Hospital Association
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Carthage, Illinois, Forenede Stater, 62321
    - Memorial Hospital
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60611
    - Hematology and Oncology Associates
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Center of Decatur
  - Decatur, Illinois, Forenede Stater, 62526
    - Central Illinois CCOP
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Eureka, Illinois, Forenede Stater, 61530
    - Eureka Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare Galesburg
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg Cottage Plaza Office
  - Havana, Illinois, Forenede Stater, 62644
    - Mason District Hospital
  - Havana, Illinois, Forenede Stater, 62644
    - Illinois CancerCare-Havana
  - Highland Park, Illinois, Forenede Stater, 60035
    - Hematology Oncology Associates of Illinois-Highland Park
  - Kankakee, Illinois, Forenede Stater, 60901
    - Presence Saint Mary's Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - La Grange, Illinois, Forenede Stater, 60525
    - Adventist La Grange Memorial Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - North Shore Hematology Oncology
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Macomb, Illinois, Forenede Stater, 61455
    - Mcdonough District Hospital
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Garneau, Stewart C MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Porubcin, Michael MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Spector, David MD (UIA Investigator)
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center
  - Monmouth, Illinois, Forenede Stater, 61462
    - Illinois CancerCare-Monmouth
  - Monmouth, Illinois, Forenede Stater, 61462
    - Holy Family Medical Center
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants Limited
  - Niles, Illinois, Forenede Stater, 60714
    - Illinois Cancer Specialists-Niles
  - Normal, Illinois, Forenede Stater, 61761
    - Community Cancer Center Foundation
  - Normal, Illinois, Forenede Stater, 61761
    - Bromenn Regional Medical Center
  - Normal, Illinois, Forenede Stater, 61761
    - Illinois CancerCare-Community Cancer Center
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forenede Stater, 61350
    - Ottawa Regional Hospital and Healthcare Center
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - Pekin Cancer Treatment Center
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61614
    - Proctor Hospital
  - Peoria, Illinois, Forenede Stater, 61603
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois Oncology Research Association CCOP
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois Valley Hospital
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Princeton, Illinois, Forenede Stater, 61356
    - Perry Memorial Hospital
  - Rockford, Illinois, Forenede Stater, 61107
    - SwedishAmerican Regional Cancer Center/ACT
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Spring Valley, Illinois, Forenede Stater, 61362
    - Illinois CancerCare-Spring Valley
  - Springfield, Illinois, Forenede Stater, 62781-0001
    - Memorial Medical Center
- Indiana
  - Elkhart, Indiana, Forenede Stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forenede Stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forenede Stater, 46514-2098
    - Elkhart Clinic
  - Fort Wayne, Indiana, Forenede Stater, 46845
    - Fort Wayne Medical Oncology and Hematology Inc-Parkview
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Saint Francis Health-Indianapolis
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forenede Stater, 46350
    - IU Health La Porte Hospital
  - Merrillville, Indiana, Forenede Stater, 46410
    - Premier Oncology Hematology Associates
  - Mishawaka, Indiana, Forenede Stater, 46544
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Saint Joseph Regional Medical Center-Mishawaka
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Cancer Care Partners LLC
  - Mishawaka, Indiana, Forenede Stater, 46545-1470
    - Michiana Hematology Oncology PC-Mishawaka
  - Plymouth, Indiana, Forenede Stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Hospital and Health Care Services
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forenede Stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forenede Stater, 46628
    - Northern Indiana Cancer Research Consortium
  - South Bend, Indiana, Forenede Stater, 46617
    - South Bend Clinic
  - Westville, Indiana, Forenede Stater, 46391
    - Michiana Hematology Oncology-PC Westville
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic PC-William R Bliss Cancer Center
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Constantinou, Costas L MD (UIA Investigator)
  - Bettendorf, Iowa, Forenede Stater, 52722
    - Hematology Oncology Associates-Quad Cities
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic PC-Boone
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - McFarland Clinic PC-Trinity Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic PC-Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic PC-Marshalltown
  - Sioux City, Iowa, Forenede Stater, 51104
    - Saint Luke's Regional Medical Center
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Hematology Oncology Associates
  - Sioux City, Iowa, Forenede Stater, 51104
    - Mercy Medical Center-Sioux City
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Medical Center
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Emporia, Kansas, Forenede Stater, 66801
    - Newman Regional Health
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Forenede Stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forenede Stater, 67530
    - Saint Rose Ambulatory and Surgery Center
  - Hays, Kansas, Forenede Stater, 67601
    - Hays Medical Center
  - Hutchinson, Kansas, Forenede Stater, 65702
    - Promise Regional Medical Center-Hutchinson
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Medical Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - Kansas City Cancer Center-West
  - Kansas City, Kansas, Forenede Stater, 66112
    - Providence Medical Center
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67901
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forenede Stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forenede Stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Overland Park, Kansas, Forenede Stater, 66210
    - Kansas City Cancer Centers-Southwest
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Via Christi Hospital-Pittsburg
  - Prairie Village, Kansas, Forenede Stater, 66208
    - Kansas City CCOP
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Shawnee Mission, Kansas, Forenede Stater, 66204
    - Kansas City Cancer Center-Shawnee Mission
  - Topeka, Kansas, Forenede Stater, 66606
    - Saint Francis Hospital and Medical Center - Topeka
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Main Office
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Regional Medical Center
  - Wichita, Kansas, Forenede Stater, 67214
    - Wichita CCOP
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Crestview Hills, Kentucky, Forenede Stater, 41017
    - Oncology Hematology Care Inc-Crestview
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70115
    - Ochsner Baptist Medical Center
  - Shreveport, Louisiana, Forenede Stater, 71130
    - Louisiana State University Health Sciences Center Shreveport
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Elkton, Maryland, Forenede Stater, 21921
    - Union Hospital of Cecil County
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48105
    - Veteran's Administration Medical Center - Ann Arbor
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Michigan Cancer Research Consortium Community Clinical Oncology Program
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan University Hospital
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Big Rapids, Michigan, Forenede Stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Dearborn, Michigan, Forenede Stater, 48124
    - Oakwood Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48236
    - Saint John Hospital and Medical Center
  - Escanaba, Michigan, Forenede Stater, 49431
    - Green Bay Oncology - Escanaba
  - Flint, Michigan, Forenede Stater, 48502
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Blanc, Michigan, Forenede Stater, 48439
    - Genesys Regional Medical Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Grand Rapids Clinical Oncology Program
  - Iron Mountain, Michigan, Forenede Stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Saint Mary Mercy Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forenede Stater, 48162
    - Community Cancer Center of Monroe
  - Muskegon, Michigan, Forenede Stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forenede Stater, 49120
    - Lakeland Community Hospital
  - Pontiac, Michigan, Forenede Stater, 48341-2985
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forenede Stater, 48060
    - Saint Joseph Mercy Port Huron
  - Reed City, Michigan, Forenede Stater, 49677
    - Spectrum Health Reed City Hospital
  - Saginaw, Michigan, Forenede Stater, 48601
    - Saint Mary's of Michigan
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Hospital
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Clinic North-Bemidgi
- Mississippi
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
- Missouri
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center-Carrie J Babb Cancer Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forenede Stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Cancer Institute
  - Kansas City, Missouri, Forenede Stater, 64131
    - Kansas City Cancer Center - South
  - Kansas City, Missouri, Forenede Stater, 64154
    - Kansas City Cancer Centers - North
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Lee's Summit, Missouri, Forenede Stater, 64064
    - Kansas City Cancer Center-Lee's Summit
  - Liberty, Missouri, Forenede Stater, 64068
    - Liberty Hospital
  - Rolla, Missouri, Forenede Stater, 65401
    - Phelps County Regional Medical Center
  - Rolla, Missouri, Forenede Stater, 65401
    - Saint John's Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Joseph, Missouri, Forenede Stater, 64507
    - Saint Joseph Oncology Inc
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Saint John's Mercy Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Comprehensive Cancer Care PC
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - Springfield, Missouri, Forenede Stater, 65804
    - Ozark Health Ventures LLC-Cancer Research for The Ozarks Springfield
- Montana
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59101
    - Montana Cancer Consortium CCOP
  - Billings, Montana, Forenede Stater, 59107-7000
    - Billings Clinic
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Great Falls, Montana, Forenede Stater, 59405
    - Big Sky Oncology
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Kearney, Nebraska, Forenede Stater, 68847
    - Good Samaritan Hospital
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology-Hematology PA
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology Hematology Associates
  - Laconia, New Hampshire, Forenede Stater, 03246
    - LRGHealthcare-Lakes Region General Hospital
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Newark, New Jersey, Forenede Stater, 07103
    - UMDNJ - New Jersey Medical School
  - Vineland, New Jersey, Forenede Stater, 08360
    - Inspira Medical Center Vineland
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - University of New Mexico
- New York
  - Elmira, New York, Forenede Stater, 14905
    - Arnot Ogden Medical Center
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - New York, New York, Forenede Stater, 10016
    - New York University Langone Medical Center
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28739
    - Hendersonville Hematology and Oncology at Pardee
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - Park Ridge Hospital Breast Health Center
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kinston, North Carolina, Forenede Stater, 28501
    - Kinston Medical Specialists PA
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hosiptal
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Rutherfordton, North Carolina, Forenede Stater, 28139
    - Rutherford Hospital
  - Statesville, North Carolina, Forenede Stater, 28677
    - Iredell Memorial Hospital
  - Wilson, North Carolina, Forenede Stater, 27893
    - Southeastern Medical Oncology Center-Wilson
  - Winston-Salem, North Carolina, Forenede Stater, 27104
    - Southeast Cancer Control Consortium CCOP
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Medical Center-Fargo
  - Fargo, North Dakota, Forenede Stater, 58122
    - Roger Maris Cancer Center
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Akron City Hospital/Cooper Cancer Center
  - Akron, Ohio, Forenede Stater, 44307
    - Akron General Medical Center
  - Barberton, Ohio, Forenede Stater, 44203
    - Summa Barberton Hospital
  - Bowling Green, Ohio, Forenede Stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Cincinnati, Ohio, Forenede Stater, 45267
    - University of Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forenede Stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forenede Stater, 45230
    - Oncology Hematology Care Inc - Anderson
  - Cincinnati, Ohio, Forenede Stater, 45219
    - Oncology and Hematology Care Inc-Taft
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc - Kenwood
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Medical Center
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Health Center
  - Dayton, Ohio, Forenede Stater, 45405
    - Grandview Hospital
  - Dayton, Ohio, Forenede Stater, 45420
    - Dayton CCOP
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Elyria, Ohio, Forenede Stater, 44035
    - Hematology Oncology Center Incorporated
  - Fairfield, Ohio, Forenede Stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Lima, Ohio, Forenede Stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forenede Stater, 45804
    - Lima Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Oregon, Ohio, Forenede Stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forenede Stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Sylvania, Ohio, Forenede Stater, 43560
    - Flower Hospital
  - Tiffin, Ohio, Forenede Stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forenede Stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forenede Stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forenede Stater, 43606
    - The Toledo Hospital/Toledo Children's Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Saint Anne Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Wauseon, Ohio, Forenede Stater, 43567
    - Fulton County Health Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433-5529
    - Wright-Patterson Medical Center
  - Xenia, Ohio, Forenede Stater, 45385
    - Greene Memorial Hospital
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Tulsa Cancer Institute
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - Oklahoma Oncology Inc
  - Tulsa, Oklahoma, Forenede Stater, 74136
    - Warren Cancer Research Foundation
- Oregon
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Milwaukie, Oregon, Forenede Stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Western Oncology Research Consortium
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18105
    - Lehigh Valley Hospital
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Lancaster, Pennsylvania, Forenede Stater, 17604
    - Lancaster General Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Hospital
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forenede Stater, 29403
    - Charleston Hematology Oncology Associates-Roper
  - Charleston, South Carolina, Forenede Stater, 29414
    - Charleston Hematology Oncology Associates PA-St. Francis
  - Charleston, South Carolina, Forenede Stater, 29414
    - Lowcountry Hematology Oncology PA-West Ashley
  - Charleston, South Carolina, Forenede Stater, 29406
    - Lowcountry Hematology Oncology PA-Charleston
  - Easley, South Carolina, Forenede Stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Andrews
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greenville, South Carolina, Forenede Stater, 29615
    - Greenville Health System Cancer Institute/Eastside
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Greer, South Carolina, Forenede Stater, 29650
    - Greenville Health System Cancer Institute-Greer
  - Mount Pleasant, South Carolina, Forenede Stater, 29464
    - Lowcountry Hematology Oncology PA-Mount Pleasant
  - Seneca, South Carolina, Forenede Stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Regional Medical Center
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Upstate Carolina CCOP
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center-Oncology Clinic
- Texas
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Veterans Administration Medical Center
- Virginia
  - Fredericksburg, Virginia, Forenede Stater, 22401
    - Fredericksburg Oncology Inc
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University
- Washington
  - Anacortes, Washington, Forenede Stater, 98221
    - Cancer Care Center at Island Hospital
  - Auburn, Washington, Forenede Stater, 98001
    - Auburn Regional Medical Center
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Hospital Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Medical Center-Edmonds
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Columbia Basin Hematology and Oncology PLLC
  - Kirkland, Washington, Forenede Stater, 98034
    - Cascade Cancer Center
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - Saint John Medical Center
  - Mount Vernon, Washington, Forenede Stater, 98274
    - Skagit Valley Hospital
  - Olympia, Washington, Forenede Stater, 98506-5166
    - Providence - Saint Peter Hospital
  - Olympia, Washington, Forenede Stater, 98507
    - Capital Medical Center
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - Good Samaritan Community Hospital
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium
  - Seattle, Washington, Forenede Stater, 98104
    - Harborview Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forenede Stater, 98112
    - Group Health Cooperative-Seattle
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98122
    - The Polyclinic
  - Seattle, Washington, Forenede Stater, 98109
    - Group Health
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - United General Hospital
  - Spokane, Washington, Forenede Stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99220
    - Rockwood Clinic
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - Saint Joseph Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Allenmore Hospital
  - Tacoma, Washington, Forenede Stater, 98415
    - MultiCare Health System
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest CCOP
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Compass Oncology Vancouver
  - Wenatchee, Washington, Forenede Stater, 98801
    - Wenatchee Valley Medical Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Sacred Heart Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Mary's Hospital
  - Green Bay, Wisconsin, Forenede Stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Saint Joseph's Hospital
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Saint Mary's Hospital
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Marshfield Clinic at James Beck Cancer Center
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Lakeview Medical Center-Marshfield Clinic
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Marshfield Clinic Cancer Care at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Saint Clare's Hospital
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Riverview Hospital
- Wyoming
  - Casper, Wyoming, Forenede Stater, 82609
    - Rocky Mountain Oncology
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år til 120 år (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

SYGDOMS KARAKTERISTIKA:

Patienter skal have fremskreden eller metastatisk histologisk eller cytologisk bekræftet adenokarcinom i spiserøret, maven eller det gastroøsofageale kryds (GEJ)
- Patienter må ikke have modtaget behandling for metastatisk eller ikke-operabel sygdom
- Patienter må ikke have hjernemetastaser
Patienter skal have målbar og/eller ikke-målbar sygdom
Patienter, der har fået testet HER-2-ekspression før patientens samtykke til denne undersøgelse, skal være HER-2-negative; hvis HER-2-ekspression ikke er blevet testet før patientens samtykke til denne undersøgelse, skal en anden prøve indsendes til HER-2-ekspression; hvis prøven er HER-2 positiv (eller hvis HER-2 ikke kunne evalueres), vil patienten ikke blive randomiseret
Patienter skal have gennemført enhver tidligere neoadjuverende og adjuverende behandling for resektabel sygdom mindst 180 dage før registrering

PATIENT KARAKTERISTIKA:

Zubrod præstationsstatus på 0-1
Hæmoglobin ≥ 9 g/dL
Absolut neutrofiltal (ANC) ≥ 1.500/mcL
Blodplader ≥ 100.000/mcL
Total bilirubin ≤ 1,5 mg/dL uanset om patienter har leverpåvirkning sekundært til tumor
ASAT og ALAT begge ≤ 3 gange institutionel øvre normalgrænse (IULN), medmindre leveren er involveret med tumor, i hvilket tilfælde både ASAT og ALAT skal være ≤ 5 gange IULN
Serumkreatinin < 1,5 mg/dL inden for 28 dage før registrering OG/ELLER beregnet kreatininclearance > 60 ml/min.
Patienter må ikke have motorisk eller sensorisk neuropati > grad 1 ved brug af CTCAE version 4.0
Patienter må ikke være gravide eller ammende; kvinder og mænd med reproduktionspotentiale skal have accepteret at bruge en effektiv præventionsmetode
Ingen anden tidligere malignitet er tilladt med undtagelse af følgende: tilstrækkeligt behandlet basalcelle- eller planocellulær hudcancer, in situ livmoderhalskræft, tilstrækkeligt behandlet stadium I eller II cancer, hvorfra patienten i øjeblikket er i fuldstændig remission, eller enhver anden cancer, hvorfra patienten har været sygdomsfri i fem år

FORUDSÆTNING SAMTYDLIG TERAPI:

Se Sygdomskarakteristika
Al palliativ strålebehandling alene skal være afsluttet mindst 14 dage før registrering
Patienten må ikke have planer om at modtage samtidig kemoterapi, hormonbehandling, strålebehandling, immunterapi eller nogen anden form for terapi til behandling af cancer, mens han er i denne protokolbehandling

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm I FOLFOX-kur: Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV over 46-48 timer på dag 1-2. Kurser gentages hver 14. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: FOLFOX regime Givet IV. Fluorouracil, oxaliplatin og leucovorin calcium. Medicin: fluorouracil 400 mg/m^2, IV bolus på dag 1 i hver 14-dages cyklus; 2400 mg/m^2 IV over 46-48 timer på dag 1-2 i hver 14-dages cyklus. Andre navne: 5-FU 5-fluoruracil NSC-19893 Medicin: leucovorin calcium 400 mg/m^2, IV over 2 timer på dag 1 i hver 14-dages cyklus. Andre navne: NSC-3590 Medicin: oxaliplatin 85 mg/m^2, IV over 2 timer på dag 1 i hver 14-dages cyklus. Andre navne: Eloxatin NSC-266046
Eksperimentel: Arm II Patienterne får irinotecanhydrochlorid IV over 90 minutter og docetaxel IV over 30-60 minutter på dag 1 og 8. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: docetaxel 30 mg/m^2, IV over 30 minutter på dag 1,8 i hver 21-dages cyklus. Andre navne: Taxotere RP56976 NSC-628503 Medicin: irinotecan hydrochlorid 65 mg/m^2, IV over 90 minutter på dag 1 og 8 i hver 21-dages cyklus. Andre navne: CPT-11 NSC-616348

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Arm I

FOLFOX-kur: Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV over 46-48 timer på dag 1-2. Kurser gentages hver 14. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Medicin: FOLFOX regime

Givet IV. Fluorouracil, oxaliplatin og leucovorin calcium.

Medicin: fluorouracil

400 mg/m^2, IV bolus på dag 1 i hver 14-dages cyklus; 2400 mg/m^2 IV over 46-48 timer på dag 1-2 i hver 14-dages cyklus.

Andre navne:

5-FU
5-fluoruracil
NSC-19893

Medicin: leucovorin calcium

400 mg/m^2, IV over 2 timer på dag 1 i hver 14-dages cyklus.

Andre navne:

NSC-3590

Medicin: oxaliplatin

85 mg/m^2, IV over 2 timer på dag 1 i hver 14-dages cyklus.

Andre navne:

Eloxatin
NSC-266046

Eksperimentel: Arm II

Patienterne får irinotecanhydrochlorid IV over 90 minutter og docetaxel IV over 30-60 minutter på dag 1 og 8. Kurser gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Medicin: docetaxel

30 mg/m^2, IV over 30 minutter på dag 1,8 i hver 21-dages cyklus.

Andre navne:

Taxotere
RP56976
NSC-628503

Medicin: irinotecan hydrochlorid

65 mg/m^2, IV over 90 minutter på dag 1 og 8 i hver 21-dages cyklus.

Andre navne:

CPT-11
NSC-616348

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Progressionsfri overlevelse (PFS) hos patienter med høj ERCC1 Tidsramme: Op til 3 år efter registrering	Progressionsfri overlevelse er længden af tid mellem protokolregistrering og sygdomsprogression eller død, alt efter hvad der indtræffer først.	Op til 3 år efter registrering
PFS i lav-ERCC1-deltagere Tidsramme: Op til 3 år efter registrering	Progressionsfri overlevelse er længden af tid mellem protokolregistrering og sygdomsprogression eller død, alt efter hvad der indtræffer først.	Op til 3 år efter registrering
Samlet overlevelse (OS) Tidsramme: Op til 3 år efter registrering	OS er længden af tid mellem protokolregistrering og patientens død	Op til 3 år efter registrering

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Antal deltagere med gr 3 til 5 uønskede hændelser, der er relateret til undersøgelsesstoffer Tidsramme: Behandlingsvarighed og opfølgning indtil død eller 3 år efter registrering	Uønskede hændelser (AE'er) rapporteres af CTCAE version 4.0. Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til undersøgelseslægemidlet, er rapporteret.	Behandlingsvarighed og opfølgning indtil død eller 3 år efter registrering
Samlet responsrate (ORR) Tidsramme: Op til 3 år efter registrering	ORR (komplet respons, ubekræftet fuldstændigt respons, delvist respons, ubekræftet delvist respons) hos patienter med målbar sygdom blev vurderet i hver arm og sammenlignet mellem armene ved hjælp af Chi-kvadrattest. Evalueringskriterier pr. respons i solide tumorer (RECIST v1.1) for mållæsioner og vurderet ved MR: Komplet respons (CR), forsvinden af alle mållæsioner; Delvis respons (PR), >=30 % fald i summen af den længste diameter af mållæsioner; Samlet respons (OR) = CR + PR.	Op til 3 år efter registrering
PFS Variation af ERCC1 Tidsramme: op til 3 år efter registrering	Progressionsfri overlevelse er længden af tid mellem protokolregistrering og sygdomsprogression eller død, alt efter hvad der indtræffer først. Deltagerne blev opdelt i undergrupper i henhold til ERCC1-kvartiler for at vurdere, om forskellene i PFS mellem de to behandlingsarme varierede efter ERCC1-niveauer.	op til 3 år efter registrering

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Southwest Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Ledende efterforsker: Syma Iqbal, MD, University of Southern California

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. februar 2012

Primær færdiggørelse (Faktiske)

1. marts 2018

Studieafslutning (Faktiske)

19. september 2019

Datoer for studieregistrering

Først indsendt

22. december 2011

Først indsendt, der opfyldte QC-kriterier

22. december 2011

Først opslået (Skøn)

23. december 2011

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

7. november 2019

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

25. oktober 2019

Sidst verificeret

1. oktober 2019

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

S1201 (Anden identifikator: SWOG)
U10CA032102 (U.S. NIH-bevilling/kontrakt)
NCI-2012-00096 (Anden identifikator: CTRP)

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Mavekræft

Washington University School of Medicine
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

Afsluttet

At definere rollen af GLP-1 til forbedring af glukosehomeostase hos mennesker efter gastrisk bypass-kirurgi

Roux-en-Y Gastric Bypass | Bariatrisk kirurgi | Vertikal ærmegatrektomi | Mavebånd | Bypass, Gastric

Forenede Stater
Medtronic - MITG

Afsluttet

Sikkerheds- og effektivitetsundersøgelse af Duet TRS

Roux En Y Gastric Bypass

Forenede Stater
North Dakota State University
National Institutes of Health (NIH)

Afsluttet

Farmakokinetiske egenskaber af sertralin før og efter gastrisk bypass-operation

Roux en Y Gastric Bypass Operation

Forenede Stater
Duomed

Aktiv, ikke rekrutterende

Et observationsregister efter markedet med easyEndoTM Universal Linear Cutting Stapler i laparoskopisk bariatrisk kirurgi (STAP-Delta)

Fedme | Gastrectomi | Roux-en-Y Gastric Bypass | Mini Gastric Bypass

Belgien
Olympus Corporation of the Americas
Unity Health Toronto

Afsluttet

BlackBox-undersøgelsen

Laparoskopisk Roux-en-y Gastric Bypass

Canada
Jessa Hospital

Ikke rekrutterer endnu

Gennemførlighed og sundhedsøkonomisk evaluering af fjernklinisk overvågning, der muliggør udskrivning samme dag efter fedmekirurgi (REMABS)

Roux-en Y Gastric Bypass

Belgien
Wageningen University
Rijnstate Hospital

Ukendt

Ændringer i fødevarepræference og responsivitet efter fedmekirurgi (Verrukkelijk)

Roux-en-Y Gastric Bypass

Holland
North Dakota State University
Neuropsychiatric Research Institute, Fargo, North Dakota

Afsluttet

En sammenligning af bupropion med langvarig og forlænget frigivelse efter fedmekirurgi

Roux en Y Gastric Bypass

Forenede Stater
Rijnstate Hospital

Afsluttet

Forsøg med jernabsorption

Bariatrisk kirurgi | Jernoptagelse | Roux- en -y Gastric Bypass

Holland
Rijnstate Hospital

Afsluttet

Bariatriske procedurer og ændringer gastrisk passage (BIP)

Roux-en-Y Gastric Bypass | Mavetømning | Bariatrisk kirurgi

Holland

Kliniske forsøg med FOLFOX regime

Ruijin Hospital
Sun Yat-sen University; Shanghai Zhongshan Hospital; RenJi Hospital; Huashan... og andre samarbejdspartnere

Rekruttering

En prospektiv, multicenter og eksplorativ undersøgelse af CMGV i behandling af tilbagevendende voksen AML og MDS-EB-2/ældre AML

Tilbagevendende akut myeloid leukæmi hos voksne | Myelodysplastisk syndrom | Akut myeloid leukæmi hos voksne

Kina
Fox Chase Cancer Center

Aktiv, ikke rekrutterende

Organkonservering hos patienter med tidlig rektalcancer

Endetarmskræft

Forenede Stater
Canadian Cancer Trials Group

Afsluttet

NEO: Neoadjuverende kemoterapi, excision og observation for tidlig rektalcancer

Endetarmskræft

Forenede Stater, Canada
University of Rochester

Aktiv, ikke rekrutterende

Neoadjuverende FOLFOX-terapi med kortvarig stråling og aktiv overvågning ved lokalt fremskreden rektalcancer

Avanceret endetarmskræft

Forenede Stater
Shanghai Zhongshan Hospital

Rekruttering

NALIRIFOX plus målrettet terapi versus FOLFOX plus målrettet terapi som første-linjesbehandling for metastatisk kolorektalkræft

Metastatisk kolorektal cancer (CRC)

Kina
Jules Bordet Institute

Afsluttet

Præoperativ kemosensitivitetstest for at forudsige behandlingsfordele ved adjuverende trin III tyktarmskræft (PePiTA)

Tyktarmskræft

Belgien
University of Saskatchewan

Afsluttet

FOLFIRI veksler med FOLFOX ved ubehandlet metastatisk gastrisk og esophagealt adenokarcinom (LOGIC)

Metastatisk gastroøsofagealt adenokarcinom

Canada
UNICANCER
Summit Therapeutics; Cancer Research UK & UCL Cancer Trials Centre; Belgian...

Rekruttering

Test af Ivonescimab versus FOLFOX hos patienter med avanceret galdevejskræft (SEVILLA)

Galdevejskræft

Frankrig, Det Forenede Kongerige
Sun Yat-sen University

Rekruttering

Neoadjuverende HAIC for resektabelt hepatocellulært karcinom ud over Milanos kriterier

Hepatocellulært karcinom

Kina
UNICANCER

Rekruttering

Dosisindividualisering af kemoterapi hos patienter med gastrointestinale kræftformer, der mangler et specifikt leverenzym (FUDOSE)

Kolorektal cancer | Fordøjelseskræft

Frankrig

S1201: Kombinationskemo til patienter med avanceret eller metastatisk spiserørs-, gastrisk- eller gastroøsofageal Junction-kræft

Et randomiseret fase II-pilotstudie, der prospektivt evaluerer behandling for patienter baseret på ERCC1 (Excision Repair Cross-Complementing 1) for avanceret/metastatisk kræft i spiserør, gastrisk eller gastroøsofageal Junction (GEJ)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Køn, der er berettiget til at studere

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Skøn)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Kliniske forsøg med Mavekræft

Kliniske forsøg med FOLFOX regime

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Cyprus

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer