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S1202: Duloxetinhydrochlorid mod muskel-/ledsmerter i tidligt stadie af brystkræft, der modtager hormonbehandling

14. december 2022 opdateret af: Southwest Oncology Group

Et randomiseret placebo-kontrolleret fase III-studie af duloxetin til behandling af aromatasehæmmer-associerede muskel- og skeletsymptomer hos kvinder med tidligt stadium af brystkræft

RATIONALE: Duloxetinhydrochlorid kan mindske muskel-, knogle- og ledsmerter forårsaget af hormonbehandling. Det vides endnu ikke, om duloxetinhydrochlorid er mere effektivt end placebo til behandling af patienter med muskel-, knogle- og ledsmerter forårsaget af hormonbehandling.

FORMÅL: Dette randomiserede fase III-forsøg undersøger, hvor godt duloxetinhydrochlorid virker sammenlignet med placebo til behandling af muskel-, knogle- og ledsmerter hos patienter med tidligt stadie af brystkræft, der får hormonbehandling.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

MÅL:

Primær

  • At vurdere, om dagligt duloxetinhydrochlorid (duloxetin) reducerer gennemsnitlige ledsmerter hos kvinder med aromatasehæmmer-associeret muskuloskeletalt syndrom (AIMSS), målt efter 12 uger ved den modificerede Brief Pain Inventory Short Form (BPI-SF).

Sekundær

  • At vurdere, om daglig duloxetin mindsker de værste ledsmerter hos kvinder med AIMSS, målt efter 12 uger med den modificerede BPI-SF.
  • At vurdere, om daglig duloxetin reducerer smerteinterferens hos kvinder med AIMSS, målt efter 12 uger med den modificerede BPI-SF.
  • At undersøge om daglig duloxetin forbedrer funktion, smerte og stivhed i knæ/hofter i henhold til Western Ontario og McMaster Universities Osteoarthritis (WOMAC) skala. (Undersøgende)
  • At undersøge om daglig duloxetin forbedrer funktion, smerte og stivhed i hænderne i henhold til den ændrede score for vurdering og kvantificering af kroniske reumatoide påvirkninger af hænderne (M-SACRAH). (Undersøgende)
  • At undersøge om daglig duloxetin forbedrer den funktionelle livskvalitet målt ved Functional Assessment of Cancer Therapy-Endocrine Scale (FACT-ES). (Undersøgende)
  • At undersøge, om daglig duloxetin forbedrer andelen af ​​patienter, der rapporterer ændringer til det bedre versus det værste målt ved Global Rating of Change Scale. (Undersøgende)
  • For at undersøge, om daglig duloxetin reducerer brugen af ​​smertestillende medicin.
  • For at undersøge, om daglig duloxetin øger adhærensen til og reducerer seponeringsraten for behandling med aromatasehæmmere (AI). (Undersøgende)
  • For at vurdere, om patienter, der får duloxetin sammenlignet med placebo, har forbedret depression som målt ved Patient Health Questionnaire (PHQ-9) i uge 6 og 12. (Exploratory)
  • At udforske forholdet mellem nedarvede varianter i gener, der er ansvarlige for duloxetin metabolisme og aktivitet (COMT, HTR3A, SLC6A2, SLC6A4, CYP1A2, CYP2D6) og aromatase (CYP19A1) og ændring i smerte med 12 ugers behandling. (Undersøgende)
  • At udforske virkningen af ​​behandlingen på seruminflammatoriske cytokinniveauer med 12 ugers behandling ved baseline og 12 uger. (Undersøgende)
  • At banke blodprøver til fremtidige korrelative analyser. (Undersøgende)

OVERSIGT: Dette er en multicenterundersøgelse. Patienterne stratificeres efter baseline smertescore (4-6 vs 7-10) og tidligere taxanbrug (ja vs nej). Patienterne randomiseres til 1 ud af 2 behandlingsarme.

  • Arm I: Patienterne får duloxetinhydrochlorid oralt (PO) én gang dagligt (QD) på dag 1-7, to gange dagligt (BID) på dag 8-84 og derefter QD på dag 85-91.
  • Arm II: Patienter modtager placebo PO QD på dag 1-7, BID på dag 8-84 og derefter QD på dag 85-91.

Patienter udfylder det modificerede kortformede korte smerteopgørelsesskema (BPI-SF) spørgeskema ved baseline og periodisk under undersøgelsesbehandlingen. Patienter kan også gennemføre Western Ontario og McMaster Universities Osteoarthritis (WOMAC) skalaen, den modificerede score for vurdering og kvantificering af kroniske reumatoide påvirkninger af hænderne (M-SACRAH), den funktionelle vurdering af kræftterapi-endokrin skala (FACT-ES) ), Global Rating of Change Scale og patientsundhedsspørgeskemaet (PHQ-9).

Patienter gennemgår blodprøvetagning ved baseline og periodisk under behandlingen til korrelative undersøgelser, herunder biomarkør- og genetiske undersøgelser.

Efter afslutning af undersøgelsesbehandlingen følges patienterne op i 168 dage.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

299

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 99508
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Forenede Stater, 99508
        • Katmai Oncology Group
      • Anchorage, Alaska, Forenede Stater, 99508
        • Providence Alaska Medical Center
      • Fairbanks, Alaska, Forenede Stater, 99701
        • Fairbanks Memorial Hospital
    • Arkansas
      • Jonesboro, Arkansas, Forenede Stater, 72401
        • Fowler Family Center for Cancer Care
    • California
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Auburn, California, Forenede Stater, 95602
        • Sutter Auburn Faith Hospital
      • Berkeley, California, Forenede Stater, 94704
        • Alta Bates Summit Medical Center-Herrick Campus
      • Burlingame, California, Forenede Stater, 94010
        • Mills - Peninsula Hospitals
      • Castro Valley, California, Forenede Stater, 94546
        • Eden Hospital Medical Center
      • Castro Valley, California, Forenede Stater, 94546
        • East Bay Radiation Oncology Center
      • Castro Valley, California, Forenede Stater, 94546
        • Valley Medical Oncology Consultants-Castro Valley
      • Davis, California, Forenede Stater, 95616
        • Sutter Davis Hospital
      • Dublin, California, Forenede Stater, 94568
        • Epic Care-Dublin
      • Emeryville, California, Forenede Stater, 94608
        • Bay Area Breast Surgeons Inc
      • Emeryville, California, Forenede Stater, 94608
        • Epic Care Partners in Cancer Care
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fremont, California, Forenede Stater, 94538
        • Valley Medical Oncology Consultants-Fremont
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente
      • Loma Linda, California, Forenede Stater, 92354
        • Loma Linda University Medical Center
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars-Sinai Medical Center
      • Martinez, California, Forenede Stater, 94553-3156
        • Contra Costa Regional Medical Center
      • Modesto, California, Forenede Stater, 95355
        • Memorial Medical Center
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente-Modesto
      • Mountain View, California, Forenede Stater, 94040
        • El Camino Hospital
      • Mountain View, California, Forenede Stater, 94040
        • Palo Alto Medical Foundation-Camino Division
      • Mountain View, California, Forenede Stater, 94040
        • Palo Alto Medical Foundation-Gynecologic Oncology
      • Novato, California, Forenede Stater, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94609
        • Alta Bates Summit Medical Center - Summit Campus
      • Oakland, California, Forenede Stater, 94609
        • Hematology and Oncology Associates-Oakland
      • Oakland, California, Forenede Stater, 94602
        • Highland General Hospital
      • Oakland, California, Forenede Stater, 94609
        • Tom K Lee Inc
      • Oakland, California, Forenede Stater, 94609
        • Bay Area Tumor Institute
      • Palo Alto, California, Forenede Stater, 94301
        • Palo Alto Medical Foundation Health Care
      • Pasadena, California, Forenede Stater, 91105
        • Huntington Memorial Hospital
      • Pleasanton, California, Forenede Stater, 94588
        • Valley Medical Oncology Consultants
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Roseville, California, Forenede Stater, 95661
        • Sutter Roseville Medical Center
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente - Sacramento
      • Sacramento, California, Forenede Stater, 95816
        • Sutter General Hospital
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forenede Stater, 94115
        • California Pacific Medical Center-Pacific Campus
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Pablo, California, Forenede Stater, 94806
        • Doctors Medical Center- JC Robinson Regional Cancer Center
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Cruz, California, Forenede Stater, 95065
        • Palo Alto Medical Foundation-Santa Cruz
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • Santa Rosa, California, Forenede Stater, 95403
        • Sutter Pacific Medical Foundation
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Sunnyvale, California, Forenede Stater, 94086
        • Palo Alto Medical Foundation-Sunnyvale
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vacaville, California, Forenede Stater, 95687
        • Northbay Cancer Center
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Vallejo, California, Forenede Stater, 94589
        • Sutter Solano Medical Center/Cancer Center
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Whittier, California, Forenede Stater, 90602
        • Presbyterian Intercommunity Hospital
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80222
        • Colorado Cancer Research Program NCORP
      • Durango, Colorado, Forenede Stater, 81301
        • Mercy Medical Center
      • Durango, Colorado, Forenede Stater, 81301
        • Southwest Oncology PC
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Englewood, Colorado, Forenede Stater, 80113
        • Comprehensive Cancer Care and Research Institute of Colorado LLC
      • Golden, Colorado, Forenede Stater, 80401
        • Mountain Blue Cancer Care Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Greenwood Village, Colorado, Forenede Stater, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lakewood, Colorado, Forenede Stater, 80228
        • Saint Anthony Hospital
      • Lakewood, Colorado, Forenede Stater, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Forenede Stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Forenede Stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, Forenede Stater, 80501
        • Longmont United Hospital
      • Longmont, Colorado, Forenede Stater, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Parker, Colorado, Forenede Stater, 80138
        • Parker Adventist Hospital
      • Parker, Colorado, Forenede Stater, 80138
        • Rocky Mountain Cancer Centers-Parker
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
      • Pueblo, Colorado, Forenede Stater, 81008
        • Rocky Mountain Cancer Centers - Pueblo
      • Thornton, Colorado, Forenede Stater, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Farmington, Connecticut, Forenede Stater, 06030
        • University of Connecticut
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Greenwich Hospital
      • Hartford, Connecticut, Forenede Stater, 06105
        • Smilow Cancer Hospital Care Center at Saint Francis
      • Middletown, Connecticut, Forenede Stater, 06457
        • Middlesex Hospital
    • District of Columbia
      • Washington, District of Columbia, Forenede Stater, 20002
        • Kaiser Permanente-Capitol Hill Medical Center
    • Florida
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Holy Cross Hospital
      • Jupiter, Florida, Forenede Stater, 33458
        • Jupiter Medical Center
      • Lake Worth, Florida, Forenede Stater, 33461
        • Cancer Center of South Florida-Lake Worth
      • Lakeland, Florida, Forenede Stater, 33805
        • The Watson Clinic
      • Miami Beach, Florida, Forenede Stater, 33140
        • Mount Sinai Medical Center
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Hospital Orlando
      • Pensacola, Florida, Forenede Stater, 32504
        • Sacred Heart Hospital
    • Georgia
      • Athens, Georgia, Forenede Stater, 30607
        • University Cancer and Blood Center LLC
      • Augusta, Georgia, Forenede Stater, 30912
        • Augusta University Medical Center
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
      • Valdosta, Georgia, Forenede Stater, 31602
        • South Georgia Medical Center/Pearlman Cancer Center
    • Hawaii
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Pali Momi Medical Center
      • 'Aiea, Hawaii, Forenede Stater, 96701
        • Hawaii Oncology Inc-Pali Momi
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Straub Clinic and Hospital
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente Moanalua Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Hawaii Cancer Care Inc-POB II
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Oncology Inc-Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96859
        • Tripler Army Medical Center
      • Kailua, Hawaii, Forenede Stater, 96734
        • Castle Medical Center
      • Lihue, Hawaii, Forenede Stater, 96766
        • Wilcox Memorial Hospital and Kauai Medical Clinic
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Medical Center
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Cancer Center
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Kootenai Cancer Clinic
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush - Copley Medical Center
      • Berwyn, Illinois, Forenede Stater, 60402
        • Mac Neal Hospital
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare-Bloomington
      • Bloomington, Illinois, Forenede Stater, 61701
        • Saint Joseph Medical Center
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Forenede Stater, 62902
        • Memorial Hospital of Carbondale
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60640
        • Weiss Memorial Hospital
      • Danville, Illinois, Forenede Stater, 61832
        • Carle on Vermilion
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Heartland Cancer Research NCORP
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Center of Decatur
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forenede Stater, 62401
        • Carle Physician Group-Effingham
      • Elk Grove Village, Illinois, Forenede Stater, 60007
        • AMITA Health Alexian Brothers Medical Center
      • Elmhurst, Illinois, Forenede Stater, 60126
        • Elmhurst Memorial Hospital
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare-Eureka
      • Evergreen Park, Illinois, Forenede Stater, 60805
        • Little Company of Mary Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare-Galesburg
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Memorial Hospital
      • Hinsdale, Illinois, Forenede Stater, 60521
        • Hinsdale Hematology Oncology Associates Incorporated
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Forenede Stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Monmouth, Illinois, Forenede Stater, 61462
        • Illinois CancerCare-Monmouth
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • Good Samaritan Regional Health Center
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center Foundation
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, Forenede Stater, 61350
        • Radiation Oncology of Northern Illinois
      • Pekin, Illinois, Forenede Stater, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Forenede Stater, 61554
        • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forenede Stater, 61615
        • OSF Saint Francis Radiation Oncology at Peoria Cancer Center
      • Peoria, Illinois, Forenede Stater, 61603
        • Methodist Medical Center of Illinois
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Forenede Stater, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare-Princeton
      • River Forest, Illinois, Forenede Stater, 60305
        • West Suburban Medical Center
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Springfield, Illinois, Forenede Stater, 62702
        • Central Illinois Hematology Oncology Center
      • Swansea, Illinois, Forenede Stater, 62226
        • Cancer Care Specialists of Illinois-Swansea
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forenede Stater, 61801
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Yorkville, Illinois, Forenede Stater, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Crown Point, Indiana, Forenede Stater, 46307
        • Michiana Hematology Oncology PC-Crown Point
      • Elkhart, Indiana, Forenede Stater, 46515
        • Elkhart General Hospital
      • Elkhart, Indiana, Forenede Stater, 46514
        • Michiana Hematology Oncology PC-Elkhart
      • Elkhart, Indiana, Forenede Stater, 46514-2098
        • Elkhart Clinic
      • Indianapolis, Indiana, Forenede Stater, 46219
        • Community Hospital East
      • Indianapolis, Indiana, Forenede Stater, 46256
        • Community Regional Cancer Care-North
      • Kokomo, Indiana, Forenede Stater, 46904
        • Community Howard Regional Health
      • La Porte, Indiana, Forenede Stater, 46350
        • IU Health La Porte Hospital
      • Merrillville, Indiana, Forenede Stater, 46410
        • Premier Oncology Hematology Associates
      • Michigan City, Indiana, Forenede Stater, 46360
        • Franciscan Saint Anthony Health-Michigan City
      • Michigan City, Indiana, Forenede Stater, 46360
        • Woodland Cancer Care Center
      • Mishawaka, Indiana, Forenede Stater, 46544
        • Memorial Regional Cancer Center Day Road
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Michiana Hematology Oncology PC-Mishawaka
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Saint Joseph Regional Medical Center-Mishawaka
      • Plymouth, Indiana, Forenede Stater, 46563
        • Michiana Hematology Oncology PC-Plymouth
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Health
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • South Bend, Indiana, Forenede Stater, 46601
        • Michiana Hematology Oncology PC-South Bend
      • South Bend, Indiana, Forenede Stater, 46628
        • Northern Indiana Cancer Research Consortium
      • Valparaiso, Indiana, Forenede Stater, 46383
        • Porter Memorial Hospital
      • Westville, Indiana, Forenede Stater, 46391
        • Michiana Hematology Oncology PC-Westville
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • Mary Greeley Medical Center
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC-William R Bliss Cancer Center
      • Boone, Iowa, Forenede Stater, 50036
        • McFarland Clinic PC-Boone
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Medical Oncology and Hematology Associates-Des Moines
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa-Wide Oncology Research Coalition NCORP
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Fairfield, Iowa, Forenede Stater, 52556
        • JCHC McCreery Cancer Center
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • McFarland Clinic PC-Trinity Cancer Center
      • Jefferson, Iowa, Forenede Stater, 50129
        • McFarland Clinic PC-Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • McFarland Clinic PC-Marshalltown
      • Mason City, Iowa, Forenede Stater, 50401
        • Mercy Medical Center - North Iowa
      • Ottumwa, Iowa, Forenede Stater, 52501
        • Ottumwa Regional Health Center
      • Sioux City, Iowa, Forenede Stater, 51101
        • Siouxland Regional Cancer Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Saint Luke's Regional Medical Center
      • Sioux City, Iowa, Forenede Stater, 51104
        • Mercy Medical Center-Sioux City
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Methodist West Hospital
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67905
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, Forenede Stater, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Overland Park, Kansas, Forenede Stater, 66213
        • Saint Luke's South Hospital
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Prairie Village, Kansas, Forenede Stater, 66208
        • Kansas City NCI Community Oncology Research Program
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Topeka, Kansas, Forenede Stater, 66604
        • Stormont-Vail Regional Health Center
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Corbin, Kentucky, Forenede Stater, 40701
        • Baptist Health Corbin
      • Crestview Hills, Kentucky, Forenede Stater, 41017
        • Oncology Hematology Care Inc-Crestview
      • Elizabethtown, Kentucky, Forenede Stater, 42701
        • Hardin Memorial Hospital
      • Lexington, Kentucky, Forenede Stater, 40503
        • Baptist Health Lexington
      • Louisville, Kentucky, Forenede Stater, 40207
        • Baptist Health Louisville
      • Madisonville, Kentucky, Forenede Stater, 42431
        • Baptist Health Madisonville/Merle Mahr Cancer Center
      • Owensboro, Kentucky, Forenede Stater, 42303
        • Owensboro Health Mitchell Memorial Cancer Center
      • Paducah, Kentucky, Forenede Stater, 42003
        • Baptist Health Paducah
    • Louisiana
      • Alexandria, Louisiana, Forenede Stater, 71301
        • Christus Saint Frances Cabrini Hospital
      • Monroe, Louisiana, Forenede Stater, 71202
        • University Health-Conway
      • Shreveport, Louisiana, Forenede Stater, 71103
        • Louisiana State University Health Sciences Center Shreveport
      • Shreveport, Louisiana, Forenede Stater, 71105
        • CHRISTUS Highland Medical Center
    • Maine
      • Augusta, Maine, Forenede Stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forenede Stater, 04401
        • Eastern Maine Medical Center
      • Lewiston, Maine, Forenede Stater, 04240
        • Central Maine Medical Center
      • Rockport, Maine, Forenede Stater, 04856
        • Penobscot Bay Medical Center
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21244
        • Kaiser Permanente-Woodlawn Medical Center
      • Bethesda, Maryland, Forenede Stater, 20814
        • Suburban Hospital
      • Frederick, Maryland, Forenede Stater, 21701
        • Frederick Memorial Hospital
      • Gaithersburg, Maryland, Forenede Stater, 20879
        • Kaiser Permanente-Gaithersburg Medical Center
      • Largo, Maryland, Forenede Stater, 20774
        • Kaiser Permanente - Largo Medical Center
    • Massachusetts
      • Attleboro, Massachusetts, Forenede Stater, 02703
        • Sturdy Memorial Hospital
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston Medical Center
      • Brighton, Massachusetts, Forenede Stater, 02135
        • Steward Saint Elizabeth's Medical Center
      • Fall River, Massachusetts, Forenede Stater, 02721
        • Saint Anne's Hospital
      • Fitchburg, Massachusetts, Forenede Stater, 01420
        • Simonds-Sinon Regional Cancer Center
      • Newton, Massachusetts, Forenede Stater, 02462
        • Newton-Wellesley Hospital
      • Norwood, Massachusetts, Forenede Stater, 02062
        • Norwood Hospital
      • Springfield, Massachusetts, Forenede Stater, 01199
        • Baystate Medical Center
      • Worcester, Massachusetts, Forenede Stater, 01655
        • University of Massachusetts Medical School
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Bixby Medical Center
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106-0995
        • Saint Joseph Mercy Hospital
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University of Michigan Comprehensive Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Michigan Cancer Research Consortium NCORP
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Bay City, Michigan, Forenede Stater, 48706
        • McLaren-Bay Region
      • Big Rapids, Michigan, Forenede Stater, 49307
        • Spectrum Health Big Rapids Hospital
      • Clarkston, Michigan, Forenede Stater, 48346
        • Great Lakes Cancer Institute
      • Dearborn, Michigan, Forenede Stater, 48124
        • Beaumont Hospital-Dearborn
      • Detroit, Michigan, Forenede Stater, 48202
        • Henry Ford Hospital
      • Detroit, Michigan, Forenede Stater, 48236
        • Saint John Hospital and Medical Center
      • Detroit, Michigan, Forenede Stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Escanaba, Michigan, Forenede Stater, 49829
        • Green Bay Oncology - Escanaba
      • Farmington Hills, Michigan, Forenede Stater, 48334
        • Weisberg Cancer Treatment Center
      • Flint, Michigan, Forenede Stater, 48502
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48532
        • Singh and Arora Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Cancer Research Consortium of West Michigan NCORP
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Green Bay Oncology - Iron Mountain
      • Jackson, Michigan, Forenede Stater, 49201
        • Allegiance Health
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49001
        • Borgess Medical Center
      • Lansing, Michigan, Forenede Stater, 48912
        • Sparrow Hospital
      • Lansing, Michigan, Forenede Stater, 48910
        • McLaren-Greater Lansing
      • Livonia, Michigan, Forenede Stater, 48154
        • Saint Mary Mercy Hospital
      • Midland, Michigan, Forenede Stater, 48670
        • Mid-Michigan Medical Center - Midland
      • Monroe, Michigan, Forenede Stater, 48162
        • Mercy Memorial Hospital
      • Monroe, Michigan, Forenede Stater, 48162
        • Toledo Clinic Cancer Centers-Monroe
      • Mount Clemens, Michigan, Forenede Stater, 48043
        • McLaren Cancer Institute-Macomb
      • Mount Pleasant, Michigan, Forenede Stater, 48858
        • McLaren Cancer Institute-Central Michigan
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Niles, Michigan, Forenede Stater, 49120
        • Lakeland Community Hospital
      • Petoskey, Michigan, Forenede Stater, 49770
        • McLaren Cancer Institute-Northern Michigan
      • Pontiac, Michigan, Forenede Stater, 48341
        • Saint Joseph Mercy Oakland
      • Port Huron, Michigan, Forenede Stater, 48060
        • Lake Huron Medical Center
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saginaw, Michigan, Forenede Stater, 48601
        • Saint Mary's of Michigan
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Marie Yeager Cancer Center
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Lakeland Hospital
      • Southfield, Michigan, Forenede Stater, 48075
        • Providence Hospital-Southfield Cancer Center
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Troy, Michigan, Forenede Stater, 48098
        • William Beaumont Hospital - Troy
      • Warren, Michigan, Forenede Stater, 48093
        • Saint John Macomb-Oakland Hospital
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Clinic North-Bemidgi
      • Brainerd, Minnesota, Forenede Stater, 56401
        • Essentia Health Saint Joseph's Medical Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Saint Mary's Medical Center
      • Duluth, Minnesota, Forenede Stater, 55805
        • Miller-Dwan Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fergus Falls, Minnesota, Forenede Stater, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Hutchinson, Minnesota, Forenede Stater, 55350
        • Hutchinson Area Health Care
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Health Partners Inc
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • University of Mississippi Medical Center
      • Oxford, Mississippi, Forenede Stater, 38655
        • Family Cancer Center-Oxford
      • Pascagoula, Mississippi, Forenede Stater, 39581
        • Singing River Hospital
      • Southaven, Mississippi, Forenede Stater, 38671
        • Family Cancer Center-Southhaven
      • Southhaven, Mississippi, Forenede Stater, 38671
        • Baptist Memorial Hospital-Desoto
    • Missouri
      • Bonne Terre, Missouri, Forenede Stater, 63628
        • Parkland Health Center-Bonne Terre
      • Branson, Missouri, Forenede Stater, 65616
        • CoxHealth Cancer Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Independence, Missouri, Forenede Stater, 64057
        • Centerpoint Medical Center LLC
      • Jefferson City, Missouri, Forenede Stater, 65109
        • Capital Region Medical Center-Goldschmidt Cancer Center
      • Joplin, Missouri, Forenede Stater, 64804
        • Freeman Health System
      • Joplin, Missouri, Forenede Stater, 64804
        • Mercy Hospital-Joplin
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64118
        • Heartland Hematology and Oncology Associates Incorporated
      • Lee's Summit, Missouri, Forenede Stater, 64086
        • Saint Luke's East - Lee's Summit
      • Liberty, Missouri, Forenede Stater, 64068
        • Liberty Radiation Oncology Center
      • Rolla, Missouri, Forenede Stater, 65401
        • Delbert Day Cancer Institute at PCRMC
      • Rolla, Missouri, Forenede Stater, 65401
        • Saint John's Clinic-Rolla-Cancer and Hematology
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • Saint Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • Saint Louis, Missouri, Forenede Stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Cancer Research for the Ozarks NCORP
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
      • Sullivan, Missouri, Forenede Stater, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Forenede Stater, 63127
        • Missouri Baptist Outpatient Center-Sunset Hills
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59101
        • Montana Cancer Consortium NCORP
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Butte, Montana, Forenede Stater, 59701
        • Saint James Community Hospital and Cancer Treatment Center
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
      • Helena, Montana, Forenede Stater, 59601
        • Saint Peter's Community Hospital
      • Kalispell, Montana, Forenede Stater, 59901
        • Kalispell Regional Medical Center
      • Missoula, Montana, Forenede Stater, 59804
        • Community Medical Hospital
      • Missoula, Montana, Forenede Stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59802
        • Montana Cancer Specialists
    • Nebraska
      • Kearney, Nebraska, Forenede Stater, 68847
        • CHI Health Good Samaritan
      • Lincoln, Nebraska, Forenede Stater, 68506
        • Nebraska Hematology and Oncology
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Nebraska Cancer Research Center
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Southeast Nebraska Cancer Center
      • Norfolk, Nebraska, Forenede Stater, 68701
        • Faith Regional Medical Offices West
      • North Platte, Nebraska, Forenede Stater, 69103
        • Great Plains Regional Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Forenede Stater, 68131
        • Creighton University Medical Center
      • Omaha, Nebraska, Forenede Stater, 68106
        • Missouri Valley Cancer Consortium
      • Omaha, Nebraska, Forenede Stater, 68130
        • Oncology Hematology West PC
      • Omaha, Nebraska, Forenede Stater, 68130
        • Urology Cancer Center PC
      • Omaha, Nebraska, Forenede Stater, 68124
        • Oncology Hematology West
      • Scottsbluff, Nebraska, Forenede Stater, 69361
        • Regional West Medical Center
    • Nevada
      • Henderson, Nevada, Forenede Stater, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • 21st Century Oncology - Henderson
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forenede Stater, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Cancer and Blood Specialists-Shadow
      • Las Vegas, Nevada, Forenede Stater, 89109
        • HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
      • Las Vegas, Nevada, Forenede Stater, 89113
        • HealthCare Partners Medical Group Oncology/Hematology-San Martin
      • Las Vegas, Nevada, Forenede Stater, 89121
        • Cancer Therapy and Integrative Medicine
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Cancer and Blood Specialists-Tenaya
      • Las Vegas, Nevada, Forenede Stater, 89128
        • HealthCare Partners Medical Group Oncology/Hematology-Tenaya
      • Las Vegas, Nevada, Forenede Stater, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89149
        • HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
      • Las Vegas, Nevada, Forenede Stater, 89109
        • 21st Century Oncology
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Cancer and Blood Specialists-Fort Apache
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Nevada Cancer Research Foundation CCOP
      • Las Vegas, Nevada, Forenede Stater, 89148
        • 21st Century Oncology - Fort Apache
      • Las Vegas, Nevada, Forenede Stater, 89182
        • 21st Century Oncology - Vegas Tenaya
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89503
        • Alpine Hematology-Oncology
      • Reno, Nevada, Forenede Stater, 89519
        • Reno Oncology Consultants
    • New Hampshire
      • Dover, New Hampshire, Forenede Stater, 03820
        • Wentworth-Douglass Hospital
      • Portsmouth, New Hampshire, Forenede Stater, 03802
        • Portsmouth Regional Hospital
    • New Jersey
      • Egg Harbor Township, New Jersey, Forenede Stater, 08234
        • AtlantiCare Surgery Center
      • New Brunswick, New Jersey, Forenede Stater, 08901
        • Saint Peter's University Hospital
      • Newark, New Jersey, Forenede Stater, 07112
        • Newark Beth Israel Medical Center
      • Pennington, New Jersey, Forenede Stater, 08534
        • Capital Health Medical Center-Hopewell
      • Vineland, New Jersey, Forenede Stater, 08360
        • Inspira Medical Center Vineland
      • Woodbury, New Jersey, Forenede Stater, 08096
        • Inspira Medical Center Woodbury
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • University of New Mexico Cancer Center
    • New York
      • Auburn, New York, Forenede Stater, 13021
        • Hematology Oncology Associates of Central New York-Auburn
      • Bronx, New York, Forenede Stater, 10451
        • Lincoln Medical and Mental Health Center
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Cooperstown, New York, Forenede Stater, 13326
        • Mary Imogene Bassett Hospital
      • East Syracuse, New York, Forenede Stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Elmhurst, New York, Forenede Stater, 11373
        • Elmhurst Hospital Center
      • Elmira, New York, Forenede Stater, 14905
        • Arnot Ogden Medical Center/Falck Cancer Center
      • Jamaica, New York, Forenede Stater, 11432
        • Queens Hospital Center
      • Middletown, New York, Forenede Stater, 10940
        • Orange Regional Medical Center
      • New York, New York, Forenede Stater, 10032
        • Columbia University/Herbert Irving Cancer Center
      • Rochester, New York, Forenede Stater, 14642
        • University of Rochester
      • Rochester, New York, Forenede Stater, 14620
        • Highland Hospital
      • Rome, New York, Forenede Stater, 13440
        • Hematology Oncology Associates of Central New York-Rome
      • Staten Island, New York, Forenede Stater, 10305
        • Staten Island University Hospital
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
      • Syracuse, New York, Forenede Stater, 13215
        • Hematology Oncology Associates of Central New York-Onondaga Hill
      • White Plains, New York, Forenede Stater, 10601
        • Dickstein Cancer Treatment Center
    • North Carolina
      • Asheboro, North Carolina, Forenede Stater, 27203
        • Randolph Hospital
      • Asheville, North Carolina, Forenede Stater, 28816
        • Hope Women's Cancer Centers-Asheville
      • Asheville, North Carolina, Forenede Stater, 28801
        • Cancer Care of Western North Carolina
      • Asheville, North Carolina, Forenede Stater, 28801
        • Mission Hospital-Memorial Campus
      • Belmont, North Carolina, Forenede Stater, 28012
        • Gaston Hematology and Oncology Associates-Belmont
      • Clinton, North Carolina, Forenede Stater, 28328
        • Southeastern Medical Oncology Center-Clinton
      • Gastonia, North Carolina, Forenede Stater, 28054
        • CaroMont Regional Medical Center
      • Gastonia, North Carolina, Forenede Stater, 28054
        • Gaston Hematology and Oncology Associates
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Southeastern Medical Oncology Center-Goldsboro
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Wayne Memorial Hospital
      • Greensboro, North Carolina, Forenede Stater, 27403
        • Cone Health Cancer Center
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Hendersonville Hematology and Oncology at Pardee
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Margaret R Pardee Memorial Hospital
      • Hendersonville, North Carolina, Forenede Stater, 28792
        • Park Ridge Hospital Breast Health Center
      • Jacksonville, North Carolina, Forenede Stater, 28546
        • Southeastern Medical Oncology Center-Jacksonville
      • Kernersville, North Carolina, Forenede Stater, 27284
        • Novant Health Oncology Specialists-Kernersville
      • Kinston, North Carolina, Forenede Stater, 28501
        • Kinston Medical Specialists PA
      • Leland, North Carolina, Forenede Stater, 28451
        • Cape Fear Cancer Specialists-Leland
      • Mount Airy, North Carolina, Forenede Stater, 27030
        • Novant Health Oncology Specialists-Mount Airy
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth of the Carolinas-Moore Regional Hosiptal
      • Reidsville, North Carolina, Forenede Stater, 27320
        • Annie Penn Memorial Hospital
      • Salisbury, North Carolina, Forenede Stater, 28144
        • Carolina Oncology Associates PA
      • Shelby, North Carolina, Forenede Stater, 28150
        • Cleveland Hematology and Oncology Associates PC
      • Statesville, North Carolina, Forenede Stater, 28677
        • Iredell Memorial Hospital
      • Statesville, North Carolina, Forenede Stater, 28625
        • Novant Health Oncology Specialists-Statesville
      • Thomasville, North Carolina, Forenede Stater, 27360
        • Novant Health Oncology Specialists-Davidson County
      • Washington, North Carolina, Forenede Stater, 27889
        • Marion L Shepard Cancer Center at Vidant Beaufort Hospital
      • Wilkesboro, North Carolina, Forenede Stater, 28659
        • Novant Health Oncology Specialists-Wilkesboro
      • Wilmington, North Carolina, Forenede Stater, 28401
        • New Hanover Regional Medical Center/Zimmer Cancer Center
      • Wilmington, North Carolina, Forenede Stater, 28401
        • Cape Fear Cancer Specialists
      • Wilson, North Carolina, Forenede Stater, 27893
        • Southeastern Medical Oncology Center-Wilson
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Novant Health Forsyth Medical Center
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Novant Health Oncology Specialists
      • Winston-Salem, North Carolina, Forenede Stater, 27103
        • Winston-Salem Health Care
      • Winston-Salem, North Carolina, Forenede Stater, 27104
        • Southeast Clinical Oncology Research (SCOR) Consortium NCORP
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Essentia Health Cancer Center-South University Clinic
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Clinic North-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Medical Center-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Roger Maris Cancer Center
      • Grand Forks, North Dakota, Forenede Stater, 58201
        • Altru Cancer Center
      • Minot, North Dakota, Forenede Stater, 58701
        • Trinity Cancer Care Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44307
        • Akron General Medical Center
      • Belpre, Ohio, Forenede Stater, 45714
        • Strecker Cancer Center-Belpre
      • Bowling Green, Ohio, Forenede Stater, 43402
        • Toledo Clinic Cancer Centers-Bowling Green
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Oncology Hematology Care Inc-Blue Ash
      • Cincinnati, Ohio, Forenede Stater, 45202
        • Oncology Hematology Care Inc-Eden Park
      • Cincinnati, Ohio, Forenede Stater, 45211
        • Oncology Hematology Care Inc-Mercy West
      • Cincinnati, Ohio, Forenede Stater, 45236
        • Oncology Hematology Care Inc-Kenwood
      • Cincinnati, Ohio, Forenede Stater, 45230
        • Oncology Hematology Care Inc - Anderson
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Forenede Stater, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Health Center
      • Dayton, Ohio, Forenede Stater, 45420
        • Dayton NCI Community Oncology Research Program
      • Dayton, Ohio, Forenede Stater, 45405
        • Grandview Hospital
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Radiation Oncology
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Fairfield, Ohio, Forenede Stater, 45014
        • Oncology Hematology Care Inc-Healthplex
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Hospital
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Lancaster, Ohio, Forenede Stater, 43130
        • Fairfield Medical Center
      • Lancaster, Ohio, Forenede Stater, 43130
        • Lancaster Radiation Oncology
      • Lima, Ohio, Forenede Stater, 45801
        • Saint Rita's Medical Center
      • Lima, Ohio, Forenede Stater, 45804
        • Lima Memorial Hospital
      • Marietta, Ohio, Forenede Stater, 45750
        • Marietta Memorial Hospital
      • Marion, Ohio, Forenede Stater, 43302
        • OneHealth Marion General Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
      • Mount Vernon, Ohio, Forenede Stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Newark Radiation Oncology
      • Oregon, Ohio, Forenede Stater, 43616
        • Saint Charles Hospital
      • Oregon, Ohio, Forenede Stater, 43616
        • Toledo Clinic Cancer Centers-Oregon
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Southern Ohio Medical Center
      • Springfield, Ohio, Forenede Stater, 45505
        • Springfield Regional Medical Center
      • Sylvania, Ohio, Forenede Stater, 43560
        • Flower Hospital
      • Tiffin, Ohio, Forenede Stater, 44883
        • Mercy Hospital of Tiffin
      • Toledo, Ohio, Forenede Stater, 43608
        • Saint Vincent Mercy Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forenede Stater, 43614
        • University of Toledo
      • Toledo, Ohio, Forenede Stater, 43617
        • Toledo Community Hospital Oncology Program CCOP
      • Toledo, Ohio, Forenede Stater, 43606
        • The Toledo Hospital/Toledo Children's Hospital
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Saint Anne Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Wauseon, Ohio, Forenede Stater, 43567
        • Fulton County Health Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Saint Ann's Hospital
      • Xenia, Ohio, Forenede Stater, 45385
        • Greene Memorial Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Tulsa, Oklahoma, Forenede Stater, 74136
        • Natalie Warren Bryant Cancer Center at Saint Francis
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Warren Clinic Oncology-Tulsa
    • Oregon
      • Clackamas, Oregon, Forenede Stater, 97015
        • Clackamas Radiation Oncology Center
      • Corvallis, Oregon, Forenede Stater, 97330
        • Good Samaritan Hospital
      • Milwaukie, Oregon, Forenede Stater, 97222
        • Providence Milwaukie Hospital
      • Newberg, Oregon, Forenede Stater, 97132
        • Providence Newberg Medical Center
      • Oregon City, Oregon, Forenede Stater, 97045
        • Providence Willamette Falls Medical Center
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health and Science University
      • Portland, Oregon, Forenede Stater, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Forenede Stater, 97225
        • Providence Saint Vincent Medical Center
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente Northwest
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • Doylestown, Pennsylvania, Forenede Stater, 18901
        • Doylestown Hospital
      • Easton, Pennsylvania, Forenede Stater, 18042
        • Easton Hospital
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Lewistown, Pennsylvania, Forenede Stater, 17044
        • Lewistown Hospital
      • Meadowbrook, Pennsylvania, Forenede Stater, 19046
        • Holy Redeemer Hospital and Medical Center
      • Phoenixville, Pennsylvania, Forenede Stater, 19460
        • Phoenixville Hospital
      • Pottstown, Pennsylvania, Forenede Stater, 19464
        • Pottstown Memorial Medical Center
      • Pottsville, Pennsylvania, Forenede Stater, 17901
        • Geisinger Medical Oncology-Pottsville
      • State College, Pennsylvania, Forenede Stater, 16801
        • Geisinger Medical Group
      • West Chester, Pennsylvania, Forenede Stater, 19380
        • Chester County Hospital
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
      • Williamsport, Pennsylvania, Forenede Stater, 17701
        • Susquehanna Cancer Center
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Health Cancer Center
      • Beaufort, South Carolina, Forenede Stater, 29902
        • Beaufort Memorial Hospital
      • Charleston, South Carolina, Forenede Stater, 29401
        • Roper Hospital
      • Charleston, South Carolina, Forenede Stater, 29403
        • Charleston Hematology Oncology Associates-Roper
      • Charleston, South Carolina, Forenede Stater, 29406
        • Lowcountry Hematology Oncology PA-North Charleston
      • Charleston, South Carolina, Forenede Stater, 29414
        • Charleston Hematology Oncology Associates PA-St. Francis
      • Charleston, South Carolina, Forenede Stater, 29414
        • Lowcountry Hematology Oncology PA-West Ashley
      • Easley, South Carolina, Forenede Stater, 29640
        • Greenville Health System Cancer Institute-Easley
      • Florence, South Carolina, Forenede Stater, 29506
        • McLeod Regional Medical Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Andrews
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Faris
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Memorial Hospital
      • Greenville, South Carolina, Forenede Stater, 29615
        • Greenville Health System Cancer Institute-Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Butternut
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29651
        • Gibbs Cancer Center-Pelham
      • Greer, South Carolina, Forenede Stater, 29650
        • Greenville Health System Cancer Institute-Greer
      • Mount Pleasant, South Carolina, Forenede Stater, 29464
        • Lowcountry Hematology Oncology PA-Mount Pleasant
      • Seneca, South Carolina, Forenede Stater, 29672
        • Greenville Health System Cancer Institute-Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Greenville Health System Cancer Institute-Spartanburg
    • South Dakota
      • Rapid City, South Dakota, Forenede Stater, 57701
        • Rapid City Regional Hospital
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center-Oncology Clinic
    • Tennessee
      • Bartlett, Tennessee, Forenede Stater, 38133
        • Boston Baskin Cancer Center-Bartlett
      • Memphis, Tennessee, Forenede Stater, 38120
        • Baptist Memorial Hospital and Cancer Center-Memphis
      • Memphis, Tennessee, Forenede Stater, 38120
        • Family Cancer Center-Memphis
    • Texas
      • Amarillo, Texas, Forenede Stater, 79106
        • The Don and Sybil Harrington Cancer Center
      • El Paso, Texas, Forenede Stater, 79905
        • Texas Technology University
      • Laredo, Texas, Forenede Stater, 78041
        • Doctor's Hospital of Laredo
    • Utah
      • American Fork, Utah, Forenede Stater, 84003
        • American Fork Hospital / Huntsman Intermountain Cancer Center
      • Cedar City, Utah, Forenede Stater, 84720
        • Sandra L Maxwell Cancer Center
      • Logan, Utah, Forenede Stater, 84321
        • Logan Regional Hospital
      • Murray, Utah, Forenede Stater, 84107
        • Intermountain Medical Center
      • Ogden, Utah, Forenede Stater, 84403
        • McKay-Dee Hospital Center
      • Provo, Utah, Forenede Stater, 84604
        • Utah Valley Regional Medical Center
      • Saint George, Utah, Forenede Stater, 84770
        • Dixie Medical Center Regional Cancer Center
      • Salt Lake City, Utah, Forenede Stater, 84106
        • Utah Cancer Specialists-Salt Lake City
      • Salt Lake City, Utah, Forenede Stater, 84143
        • LDS Hospital
    • Vermont
      • Berlin, Vermont, Forenede Stater, 05602
        • Central Vermont Medical Center/National Life Cancer Treatment
      • Burlington, Vermont, Forenede Stater, 05405
        • University of Vermont College of Medicine
    • Virginia
      • Burke, Virginia, Forenede Stater, 22015
        • Kaiser Permanente-Burke Medical Center
      • Charlottesville, Virginia, Forenede Stater, 22901
        • Sentara Martha Jefferson Hospital
      • Fairfax, Virginia, Forenede Stater, 22031
        • IMG Hematology Oncology 8501
      • Fredericksburg, Virginia, Forenede Stater, 22401
        • Fredericksburg Oncology Inc
      • McLean, Virginia, Forenede Stater, 22102
        • Kaiser Permanente Tysons Corner Medical Center
      • Midlothian, Virginia, Forenede Stater, 23114
        • Bon Secours Saint Francis Medical Center
      • Richmond, Virginia, Forenede Stater, 23226
        • Bon Secours Saint Mary's Hospital
    • Washington
      • Anacortes, Washington, Forenede Stater, 98221
        • Cancer Care Center at Island Hospital
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Bainbridge Island, Washington, Forenede Stater, 98110
        • Virginia Mason Bainbridge Island Medical Center
      • Bellevue, Washington, Forenede Stater, 98004
        • Overlake Hospital Medical Center
      • Bellingham, Washington, Forenede Stater, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Bremerton, Washington, Forenede Stater, 98310
        • Harrison HealthPartners Hematology and Oncology-Bremerton
      • Burien, Washington, Forenede Stater, 98166
        • Highline Medical Center-Main Campus
      • Edmonds, Washington, Forenede Stater, 98026
        • Swedish Medical Center-Edmonds
      • Federal Way, Washington, Forenede Stater, 98002
        • Virginia Mason Federal Way Medical Center
      • Gig Harbor, Washington, Forenede Stater, 98332
        • Tacoma/Valley Radiation Oncology Centers-Gig Harbor
      • Gig Harbor, Washington, Forenede Stater, 98335
        • MultiCare Gig Harbor Medical Park
      • Issaquah, Washington, Forenede Stater, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forenede Stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Kennewick, Washington, Forenede Stater, 99336
        • Northwest Cancer Clinic
      • Longview, Washington, Forenede Stater, 98632
        • PeaceHealth Saint John Medical Center
      • Lynnwood, Washington, Forenede Stater, 98036
        • Virginia Mason Lynnwood Medical Center
      • Mount Vernon, Washington, Forenede Stater, 98274
        • Skagit Valley Hospital
      • Poulsbo, Washington, Forenede Stater, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Poulsbo, Washington, Forenede Stater, 98370
        • Peninsula Cancer Center
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Puyallup, Washington, Forenede Stater, 98372
        • Tacoma/Valley Radiation Oncology Centers-Puyallup
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98195
        • University of Washington Medical Center
      • Seattle, Washington, Forenede Stater, 98104
        • Harborview Medical Center
      • Seattle, Washington, Forenede Stater, 98101
        • Virginia Mason Medical Center
      • Seattle, Washington, Forenede Stater, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forenede Stater, 98104
        • Minor and James Medical PLLC
      • Seattle, Washington, Forenede Stater, 98112
        • Group Health Cooperative-Seattle
      • Seattle, Washington, Forenede Stater, 98122-4307
        • Swedish Medical Center-First Hill
      • Sedro-Woolley, Washington, Forenede Stater, 98284
        • United General Hospital
      • Spokane, Washington, Forenede Stater, 99218
        • Evergreen Hematology and Oncology PS
      • Spokane, Washington, Forenede Stater, 99202
        • Cancer Care Northwest - Spokane South
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • Tacoma/Valley Radiation Oncology Centers-Saint Joe's
      • Tacoma, Washington, Forenede Stater, 97405
        • Tacoma/Valley Radiation Oncology Centers-Jackson Hall
      • Tacoma, Washington, Forenede Stater, 98405
        • Northwest NCI Community Oncology Research Program
      • Vancouver, Washington, Forenede Stater, 98664
        • PeaceHealth Southwest Medical Center
      • Vancouver, Washington, Forenede Stater, 98684
        • Compass Oncology Vancouver
      • Wenatchee, Washington, Forenede Stater, 98801
        • Wenatchee Valley Hospital and Clinics
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Hospital and Cancer Center
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Fond Du Lac, Wisconsin, Forenede Stater, 54935
        • Saint Agnes Hospital/Agnesian Cancer Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology Limited at Saint Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Janesville, Wisconsin, Forenede Stater, 53547
        • Mercy Health System
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Manitowoc, Wisconsin, Forenede Stater, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Bay Area Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic
      • Milwaukee, Wisconsin, Forenede Stater, 53210
        • Wheaton Franciscan Healthcare - Saint Joseph
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Green Bay Oncology - Oconto Falls
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Marshfield Clinic at James Beck Cancer Center
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Clinic-Rice Lake Center
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • HSHS Saint Nicholas Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Marshfield Clinic Cancer Care at Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology - Sturgeon Bay
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Regional Cancer Center
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Marshfield Clinic-Wausau Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic - Weston Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Aspirus UW Cancer Center
    • Wyoming
      • Casper, Wyoming, Forenede Stater, 82609
        • Rocky Mountain Oncology
      • Cheyenne, Wyoming, Forenede Stater, 82001
        • Cheyenne Regional Medical Center-West
      • Cody, Wyoming, Forenede Stater, 82414
        • Big Horn Basin Cancer Center
      • Cody, Wyoming, Forenede Stater, 82414
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

Ikke ældre end 120 år (VOKSEN, OLDER_ADULT, BARN)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Kvinde

Beskrivelse

SYGDOMS KARAKTERISTIKA:

  • Patienter skal være kvinder med histologisk bekræftet østrogenreceptor (ER)- og/eller progesteronreceptor (PgR)-positivt invasivt brystkarcinom uden tegn på metastatisk sygdom (M0)
  • Patienter skal have gennemført mastektomi eller brystbesparende operation og skal være kommet sig over alle bivirkninger af operationen
  • Patienter skal have aromatasehæmmer (AI)-associerede muskuloskeletale symptomer, der begyndte eller steg efter start af AI-behandling; nye muskuloskeletale smerter må ikke skyldes specifikt brud eller traumatisk skade
  • Patienter skal have udfyldt S1202 Brief Pain Inventory-Short Form (BPI-SF) inden for 7 dage før registrering; patienter skal have en "gennemsnitlig smerte" på mindst 4 på BPI-SF

PATIENT KARAKTERISTIKA:

  • Patienter skal være postmenopausale, som defineret ved mindst én af følgende:

    • Mindst 12 måneder siden sidste menstruation
    • Tidligere bilateral oophorektomi
    • Tidligere hysterektomi med en eller begge ovarier tilbage på plads (eller tidligere hysterektomi, hvor dokumentation for bilateral oophorektomi ikke er tilgængelig) OG follikelstimulerende hormon (FSH) værdier i overensstemmelse med de institutionelle normale værdier for den postmenopausale tilstand; hvis patienten er under 55 år, skal FSH-niveauer opnås inden for 28 dage før registrering ELLER
    • Har været i behandling med LHRH-agonist i mindst 3 måneder, og østradiolniveauer optaget inden for 28 dage før registrering er i overensstemmelse med de institutionelle normale værdier for postmenopausal tilstand.
  • Patienter skal have Zubrod præstationsstatus på 0-2
  • Patienter må ikke have nogen kendt allergi eller overfølsomhed over for duloxetin eller nogen af ​​de inaktive ingredienser i den matchende placebo

  • Patienter må ikke have nogen kontraindiceret samtidige sygdomme anført på duloxetin indlægssedlen, herunder:

    • Nuværende primær psykiatrisk diagnose (skizofreni, psykose) eller selvmordstanker, historie med bipolar lidelse eller anfaldslidelse
    • Anamnese med alkohol eller andet stofmisbrug eller afhængighed inden for 365 dage før registrering
    • Kronisk leversygdom
    • Nyresygdom i slutstadiet
    • Ukontrolleret snævervinklet glaukom
    • Klinisk signifikant koagulationsforstyrrelse
  • Kreatininclearance > 30 ml/min
  • Aspartataminotransferase (AST) og alaninaminotransferase (ALT) begge inden for 3 x øvre normalgrænse
  • Total bilirubin inden for den øvre normalgrænse
  • Patienter skal kunne udfylde undersøgelsesspørgeskemaer på engelsk eller spansk
  • Patienter må ikke have samtidig medicinsk/arthritisk sygdom, der kan forvirre eller forstyrre evaluering af smerte eller effekt, herunder: inflammatorisk arthritis (rheumatoid arthritis, systemisk lupus, spondyloarthropati, psoriasisarthritis, polymyalgia rheumatica) eller kræft, der involverer knoglerne
  • Patienter skal være villige til at indsende blodprøver til korrelative undersøgelser; baseline prøver skal tages før påbegyndelse af protokolbehandling

FORUDSÆTNING SAMTYDLIG TERAPI:

  • Se Sygdomskarakteristika
  • Hvis patienter blev behandlet med kemoterapi og/eller strålebehandling, skal disse behandlinger afsluttes mindst 28 dage før studieregistrering
  • Samtidige bisphosphonat- og trastuzumab-behandlinger er tilladt
  • Patienter bør være kommet sig over alle grad 2 eller højere bivirkninger af kemoterapi og/eller strålebehandling med undtagelse af alopeci og perifer neuropati

  • Patienter skal i øjeblikket tage en af ​​følgende aromatasehæmmer (AI) doser i mindst 21 dage, men ikke længere end 12 måneder, før registrering og planlægger at fortsætte i mindst yderligere 180 dage efter registrering

    • Anastrozol (Arimidex®) 1 mg dagligt
    • Letrozol (Femara®) 2,5 mg dagligt
    • Exemestan (Aromasin®) 25 mg dagligt
  • Patienter må ikke tage nogen kontraindiceret medicin anført på duloxetin indlægssedlen, herunder følgende: behandling med phenothiaziner, propafenon, flecainid eller linezolid; behandling med monoaminoxidase (MAO)-hæmmer inden for 14 dage før registrering; eller aktuel brug af antikoagulerende medicin (f.eks. heparin, warfarin)
  • Patienter må ikke have behov for selektive serotoningenoptagelseshæmmere (SSRI'er), serotonin- og noradrenalin-genoptagelseshæmmere (SNRI'er) eller tricykliske antidepressiva under undersøgelsesdeltagelsen; patienter skal have været i stand til at nedtrappe og afbryde behandlingen med disse lægemidler mindst 7 dage før registrering; patienter må ikke have taget duloxetin eller milnacipran inden for 90 dage før registrering
  • Patienter, der er i behandling med narkotika, tramadol, gabapentin og/eller pregabalin, skal have taget en stabil dosis i mindst 30 dage før registrering.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: BEHANDLING
  • Tildeling: TILFÆLDIGT
  • Interventionel model: PARALLEL
  • Maskning: TRIPLE

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
EKSPERIMENTEL: Arm I
Patienterne får duloxetinhydrochlorid oralt (PO) én gang dagligt (QD) på dag 1-7, to gange dagligt (BID) på dag 8-84 og derefter QD på dag 85-91.
Medicin: duloxetin hydrochlorid
Givet PO
Andre navne:
  • NSC-744012
PLACEBO_COMPARATOR: Arm II
Patienterne modtager placebo PO QD på dag 1-7, BID på dag 8-84 og derefter QD på dag 85-91.
Andet: placebo
Givet PO

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Gennemsnitlig ledsmerter ifølge BPI-SF
Tidsramme: Uge 2, 6, 12 og 24; Uge 12 rapporteret
Gennemsnitlige ledsmerter ifølge Brief Pain Inventory - Short Form (BPI-SF) gennemsnitlig smertescore (punkt #4). Dette emne har en skala fra 0 til 10, hvor 0 angiver "Ingen smerte" og 10 angiver "Smerte så slemt som du kan forestille dig".
Uge 2, 6, 12 og 24; Uge 12 rapporteret

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Værste ledsmerter ifølge BPI-SF
Tidsramme: Uge 2, 6, 12 og 24; Uge 12 rapporteret
Værste ledsmerter ifølge BPI-SF værste smertescore (punkt #2). Dette emne har en skala fra 0 til 10, hvor 0 angiver "Ingen smerte" og 10 angiver "Smerte så slemt som du kan forestille dig".
Uge 2, 6, 12 og 24; Uge 12 rapporteret
Smerteinterferens Ifølge BPI-SF
Tidsramme: Uge 2, 6, 12 og 24; Uge 12 rapporteret
Smerteinterferens i henhold til BPI-SF: dette punkt har en skala fra 0 til 10, hvor 0 indikerer "Interfererer ikke" og 10 indikerer "Fuldstændig forstyrrer".
Uge 2, 6, 12 og 24; Uge 12 rapporteret

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Southwest Oncology Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: N. Lynn Henry, MD, PhD, University of Michigan Rogel Cancer Center

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (FAKTISKE)

15. maj 2013

Primær færdiggørelse (FAKTISKE)

1. december 2016

Studieafslutning (FAKTISKE)

20. december 2018

Datoer for studieregistrering

Først indsendt

11. maj 2012

Først indsendt, der opfyldte QC-kriterier

11. maj 2012

Først opslået (SKØN)

15. maj 2012

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (FAKTISKE)

16. december 2022

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

14. december 2022

Sidst verificeret

1. december 2022

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • S1202 (ANDET: SWOG)
  • U10CA037429 (U.S. NIH-bevilling/kontrakt)
  • NCI-2012-01960 (ANDET: NCI)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

https://swog.org/Visitors/Download/Policies/Policy43.pdf

Studiedata/dokumenter

  1. Individuelt deltagerdatasæt
    Oplysningskommentarer: Tilgængelige data: Vælg individuelle data på patientniveau fra dette forsøg kan rekvireres fra NCTN/NCORP Data Archive.

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Smerte

Kliniske forsøg med placebo

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in United Arab Emirates

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

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