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S1202: Duloksetinhydroklorid for muskel-/leddsmerter i tidlig stadium av brystkreft som får hormonbehandling

14. desember 2022 oppdatert av: Southwest Oncology Group

En randomisert placebokontrollert fase III-studie av duloksetin for behandling av aromatasehemmer-assosierte muskel- og skjelettsymptomer hos kvinner med tidlig brystkreft

RASIONAL: Duloksetinhydroklorid kan redusere muskel-, skjelett- og leddsmerter forårsaket av hormonbehandling. Det er ennå ikke kjent om duloksetinhydroklorid er mer effektivt enn placebo ved behandling av pasienter med muskel-, skjelett- og leddsmerter forårsaket av hormonbehandling.

FORMÅL: Denne randomiserte fase III-studien studerer hvor godt duloksetinhydroklorid virker sammenlignet med placebo ved behandling av muskel-, skjelett- og leddsmerter hos pasienter med tidlig brystkreft som får hormonbehandling.

Studieoversikt

Status

Fullført

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

MÅL:

Hoved

For å vurdere om daglig duloksetinhydroklorid (duloksetin) reduserer gjennomsnittlig leddsmerter hos kvinner med aromatasehemmer-assosiert muskel- og skjelettsyndrom (AIMSS), målt etter 12 uker med den modifiserte kortformen for kort smerteinventar (BPI-SF).

Sekundær

For å vurdere om daglig duloksetin reduserer verste leddsmerter hos kvinner med AIMSS, målt etter 12 uker med modifisert BPI-SF.
For å vurdere om daglig duloksetin reduserer smerteinterferens hos kvinner med AIMSS, målt etter 12 uker med modifisert BPI-SF.
For å undersøke om daglig duloksetin forbedrer funksjon, smerte og stivhet i knærne/hoftene i henhold til Western Ontario og McMaster Universities Osteoarthritis (WOMAC) skala. (Utforskende)
For å undersøke om daglig duloksetin forbedrer funksjon, smerte og stivhet i hendene i henhold til Modified Score for Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH). (Utforskende)
For å undersøke om daglig duloksetin forbedrer funksjonell livskvalitet målt ved Functional Assessment of Cancer Therapy-Endocrine Scale (FACT-ES). (Utforskende)
For å undersøke om daglig duloksetin forbedrer andelen pasienter som rapporterer endringer til det bedre kontra det verste, målt ved Global Rating of Change Scale. (Utforskende)
For å undersøke om daglig duloksetin reduserer smertestillende bruk.
For å undersøke om daglig duloksetin øker adherensen til, og reduserer seponeringsfrekvensen for behandling med aromatasehemmere (AI). (Utforskende)
For å vurdere om pasienter som får duloksetin sammenlignet med placebo har forbedret depresjon målt ved pasienthelseundersøkelsen (PHQ-9) i uke 6 og 12. (Utforskende)
Å utforske forholdet mellom arvelige varianter i gener som er ansvarlige for duloksetinmetabolisme og aktivitet (COMT, HTR3A, SLC6A2, SLC6A4, CYP1A2, CYP2D6) og aromatase (CYP19A1) og endring i smerte med 12 ukers behandling. (Utforskende)
Å utforske effekten av behandling på serum inflammatoriske cytokinnivåer med 12 ukers behandling ved baseline og 12 uker. (Utforskende)
Å banke blodprøver for fremtidige korrelative analyser. (Utforskende)

OVERSIKT: Dette er en multisenterstudie. Pasientene er stratifisert etter baseline smertescore (4-6 vs 7-10), og tidligere taxanbruk (ja vs nei). Pasientene er randomisert til 1 av 2 behandlingsarmer.

Arm I: Pasienter får duloksetinhydroklorid oralt (PO) én gang daglig (QD) på dag 1-7, to ganger daglig (BID) på dag 8-84, og deretter QD på dag 85-91.
Arm II: Pasienter får placebo PO QD på dag 1-7, BID på dag 8-84, og deretter QD på dag 85-91.

Pasienter fyller ut det modifiserte spørreskjemaet for kort smerteinventar (BPI-SF) ved baseline og med jevne mellomrom under studiebehandlingen. Pasienter kan også fullføre Western Ontario og McMaster Universities Osteoarthritis (WOMAC) skalaen, Modified Score for Assessment and Quantification of Chronic Rheumatoid Affections of the Hands (M-SACRAH), Functional Assessment of Cancer Therapy-Endocrine Scale (FACT-ES) ), Global Rating of Change Scale og pasientens helsespørreskjema (PHQ-9).

Pasienter gjennomgår blodprøvetaking ved baseline og periodisk under behandling for korrelative studier, inkludert biomarkør- og genetiske studier.

Etter avsluttet studiebehandling følges pasientene opp i 168 dager.

Studietype

Intervensjonell

Registrering (Faktiske)

299

Fase

Fase 3

Kontakter og plasseringer

Denne delen inneholder kontaktinformasjon for de som utfører studien, og informasjon om hvor denne studien blir utført.

Studiesteder

Forente stater
- Alaska
  - Anchorage, Alaska, Forente stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forente stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forente stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forente stater, 99508
    - Providence Alaska Medical Center
  - Fairbanks, Alaska, Forente stater, 99701
    - Fairbanks Memorial Hospital
- Arkansas
  - Jonesboro, Arkansas, Forente stater, 72401
    - Fowler Family Center for Cancer Care
- California
  - Antioch, California, Forente stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Auburn, California, Forente stater, 95602
    - Sutter Auburn Faith Hospital
  - Berkeley, California, Forente stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burlingame, California, Forente stater, 94010
    - Mills - Peninsula Hospitals
  - Castro Valley, California, Forente stater, 94546
    - Eden Hospital Medical Center
  - Castro Valley, California, Forente stater, 94546
    - East Bay Radiation Oncology Center
  - Castro Valley, California, Forente stater, 94546
    - Valley Medical Oncology Consultants-Castro Valley
  - Davis, California, Forente stater, 95616
    - Sutter Davis Hospital
  - Dublin, California, Forente stater, 94568
    - Epic Care-Dublin
  - Emeryville, California, Forente stater, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Forente stater, 94608
    - Epic Care Partners in Cancer Care
  - Fremont, California, Forente stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forente stater, 94538
    - Valley Medical Oncology Consultants-Fremont
  - Fresno, California, Forente stater, 93720
    - Kaiser Permanente
  - Loma Linda, California, Forente stater, 92354
    - Loma Linda University Medical Center
  - Los Angeles, California, Forente stater, 90048
    - Cedars-Sinai Medical Center
  - Martinez, California, Forente stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Modesto, California, Forente stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forente stater, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Forente stater, 94040
    - El Camino Hospital
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forente stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forente stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forente stater, 94611
    - Kaiser Permanente-Oakland
  - Oakland, California, Forente stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forente stater, 94609
    - Hematology and Oncology Associates-Oakland
  - Oakland, California, Forente stater, 94602
    - Highland General Hospital
  - Oakland, California, Forente stater, 94609
    - Tom K Lee Inc
  - Oakland, California, Forente stater, 94609
    - Bay Area Tumor Institute
  - Palo Alto, California, Forente stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Pasadena, California, Forente stater, 91105
    - Huntington Memorial Hospital
  - Pleasanton, California, Forente stater, 94588
    - Valley Medical Oncology Consultants
  - Redwood City, California, Forente stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forente stater, 94801
    - Kaiser Permanente-Richmond
  - Roseville, California, Forente stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forente stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forente stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forente stater, 95825
    - Kaiser Permanente - Sacramento
  - Sacramento, California, Forente stater, 95816
    - Sutter General Hospital
  - San Francisco, California, Forente stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forente stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Jose, California, Forente stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forente stater, 94577
    - Kaiser Permanente San Leandro
  - San Pablo, California, Forente stater, 94806
    - Doctors Medical Center- JC Robinson Regional Cancer Center
  - San Rafael, California, Forente stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forente stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forente stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forente stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forente stater, 95403
    - Sutter Pacific Medical Foundation
  - South San Francisco, California, Forente stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forente stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forente stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forente stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forente stater, 95687
    - Northbay Cancer Center
  - Vallejo, California, Forente stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forente stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forente stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Whittier, California, Forente stater, 90602
    - Presbyterian Intercommunity Hospital
- Colorado
  - Aurora, Colorado, Forente stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forente stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forente stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forente stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forente stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forente stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Denver, Colorado, Forente stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forente stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forente stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forente stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forente stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forente stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forente stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forente stater, 80222
    - Colorado Cancer Research Program NCORP
  - Durango, Colorado, Forente stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forente stater, 81301
    - Southwest Oncology PC
  - Englewood, Colorado, Forente stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forente stater, 80113
    - Comprehensive Cancer Care and Research Institute of Colorado LLC
  - Golden, Colorado, Forente stater, 80401
    - Mountain Blue Cancer Care Center
  - Greeley, Colorado, Forente stater, 80631
    - North Colorado Medical Center
  - Greenwood Village, Colorado, Forente stater, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lakewood, Colorado, Forente stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forente stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forente stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forente stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forente stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forente stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forente stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forente stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forente stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forente stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forente stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forente stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forente stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forente stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Wheat Ridge, Colorado, Forente stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Farmington, Connecticut, Forente stater, 06030
    - University of Connecticut
  - Greenwich, Connecticut, Forente stater, 06830
    - Greenwich Hospital
  - Hartford, Connecticut, Forente stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Middletown, Connecticut, Forente stater, 06457
    - Middlesex Hospital
- District of Columbia
  - Washington, District of Columbia, Forente stater, 20002
    - Kaiser Permanente-Capitol Hill Medical Center
- Florida
  - Fort Lauderdale, Florida, Forente stater, 33308
    - Holy Cross Hospital
  - Jupiter, Florida, Forente stater, 33458
    - Jupiter Medical Center
  - Lake Worth, Florida, Forente stater, 33461
    - Cancer Center of South Florida-Lake Worth
  - Lakeland, Florida, Forente stater, 33805
    - The Watson Clinic
  - Miami Beach, Florida, Forente stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forente stater, 32803
    - Florida Hospital Orlando
  - Pensacola, Florida, Forente stater, 32504
    - Sacred Heart Hospital
- Georgia
  - Athens, Georgia, Forente stater, 30607
    - University Cancer and Blood Center LLC
  - Augusta, Georgia, Forente stater, 30912
    - Augusta University Medical Center
  - Savannah, Georgia, Forente stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Valdosta, Georgia, Forente stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - 'Aiea, Hawaii, Forente stater, 96701
    - Pali Momi Medical Center
  - 'Aiea, Hawaii, Forente stater, 96701
    - Hawaii Oncology Inc-Pali Momi
  - Honolulu, Hawaii, Forente stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forente stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forente stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forente stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forente stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forente stater, 96813
    - Hawaii Cancer Care Inc-POB II
  - Honolulu, Hawaii, Forente stater, 96817
    - Hawaii Oncology Inc-Kuakini
  - Honolulu, Hawaii, Forente stater, 96859
    - Tripler Army Medical Center
  - Kailua, Hawaii, Forente stater, 96734
    - Castle Medical Center
  - Lihue, Hawaii, Forente stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
- Idaho
  - Boise, Idaho, Forente stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Coeur d'Alene, Idaho, Forente stater, 83814
    - Kootenai Medical Center
  - Post Falls, Idaho, Forente stater, 83854
    - Kootenai Cancer Center
  - Sandpoint, Idaho, Forente stater, 83864
    - Kootenai Cancer Clinic
- Illinois
  - Aurora, Illinois, Forente stater, 60504
    - Rush - Copley Medical Center
  - Berwyn, Illinois, Forente stater, 60402
    - Mac Neal Hospital
  - Bloomington, Illinois, Forente stater, 61704
    - Illinois CancerCare-Bloomington
  - Bloomington, Illinois, Forente stater, 61701
    - Saint Joseph Medical Center
  - Canton, Illinois, Forente stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forente stater, 62902
    - Memorial Hospital of Carbondale
  - Carthage, Illinois, Forente stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forente stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forente stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forente stater, 60640
    - Weiss Memorial Hospital
  - Danville, Illinois, Forente stater, 61832
    - Carle on Vermilion
  - Decatur, Illinois, Forente stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forente stater, 62526
    - Heartland Cancer Research NCORP
  - Decatur, Illinois, Forente stater, 62526
    - Cancer Care Center of Decatur
  - Effingham, Illinois, Forente stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forente stater, 62401
    - Carle Physician Group-Effingham
  - Elk Grove Village, Illinois, Forente stater, 60007
    - AMITA Health Alexian Brothers Medical Center
  - Elmhurst, Illinois, Forente stater, 60126
    - Elmhurst Memorial Hospital
  - Eureka, Illinois, Forente stater, 61530
    - Illinois CancerCare-Eureka
  - Evergreen Park, Illinois, Forente stater, 60805
    - Little Company of Mary Hospital
  - Galesburg, Illinois, Forente stater, 61401
    - Illinois CancerCare-Galesburg
  - Harvey, Illinois, Forente stater, 60426
    - Ingalls Memorial Hospital
  - Hinsdale, Illinois, Forente stater, 60521
    - Hinsdale Hematology Oncology Associates Incorporated
  - Kewanee, Illinois, Forente stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Forente stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forente stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forente stater, 60153
    - Loyola University Medical Center
  - Monmouth, Illinois, Forente stater, 61462
    - Illinois CancerCare-Monmouth
  - Mount Vernon, Illinois, Forente stater, 62864
    - Good Samaritan Regional Health Center
  - Normal, Illinois, Forente stater, 61761
    - Community Cancer Center Foundation
  - Ottawa, Illinois, Forente stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Ottawa, Illinois, Forente stater, 61350
    - Radiation Oncology of Northern Illinois
  - Pekin, Illinois, Forente stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forente stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Peoria, Illinois, Forente stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forente stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forente stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Forente stater, 61603
    - Methodist Medical Center of Illinois
  - Peru, Illinois, Forente stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forente stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forente stater, 61356
    - Illinois CancerCare-Princeton
  - River Forest, Illinois, Forente stater, 60305
    - West Suburban Medical Center
  - Springfield, Illinois, Forente stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forente stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forente stater, 62702
    - Springfield Clinic
  - Springfield, Illinois, Forente stater, 62702
    - Central Illinois Hematology Oncology Center
  - Swansea, Illinois, Forente stater, 62226
    - Cancer Care Specialists of Illinois-Swansea
  - Urbana, Illinois, Forente stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forente stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forente stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Forente stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Crown Point, Indiana, Forente stater, 46307
    - Michiana Hematology Oncology PC-Crown Point
  - Elkhart, Indiana, Forente stater, 46515
    - Elkhart General Hospital
  - Elkhart, Indiana, Forente stater, 46514
    - Michiana Hematology Oncology PC-Elkhart
  - Elkhart, Indiana, Forente stater, 46514-2098
    - Elkhart Clinic
  - Indianapolis, Indiana, Forente stater, 46219
    - Community Hospital East
  - Indianapolis, Indiana, Forente stater, 46256
    - Community Regional Cancer Care-North
  - Kokomo, Indiana, Forente stater, 46904
    - Community Howard Regional Health
  - La Porte, Indiana, Forente stater, 46350
    - IU Health La Porte Hospital
  - Merrillville, Indiana, Forente stater, 46410
    - Premier Oncology Hematology Associates
  - Michigan City, Indiana, Forente stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Forente stater, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Forente stater, 46544
    - Memorial Regional Cancer Center Day Road
  - Mishawaka, Indiana, Forente stater, 46545
    - Michiana Hematology Oncology PC-Mishawaka
  - Mishawaka, Indiana, Forente stater, 46545
    - Saint Joseph Regional Medical Center-Mishawaka
  - Plymouth, Indiana, Forente stater, 46563
    - Michiana Hematology Oncology PC-Plymouth
  - Richmond, Indiana, Forente stater, 47374
    - Reid Health
  - South Bend, Indiana, Forente stater, 46601
    - Memorial Hospital of South Bend
  - South Bend, Indiana, Forente stater, 46601
    - Michiana Hematology Oncology PC-South Bend
  - South Bend, Indiana, Forente stater, 46628
    - Northern Indiana Cancer Research Consortium
  - Valparaiso, Indiana, Forente stater, 46383
    - Porter Memorial Hospital
  - Westville, Indiana, Forente stater, 46391
    - Michiana Hematology Oncology PC-Westville
- Iowa
  - Ames, Iowa, Forente stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forente stater, 50010
    - McFarland Clinic PC-William R Bliss Cancer Center
  - Boone, Iowa, Forente stater, 50036
    - McFarland Clinic PC-Boone
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forente stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Forente stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forente stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forente stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forente stater, 50309
    - Iowa-Wide Oncology Research Coalition NCORP
  - Des Moines, Iowa, Forente stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Fairfield, Iowa, Forente stater, 52556
    - JCHC McCreery Cancer Center
  - Fort Dodge, Iowa, Forente stater, 50501
    - McFarland Clinic PC-Trinity Cancer Center
  - Jefferson, Iowa, Forente stater, 50129
    - McFarland Clinic PC-Jefferson
  - Marshalltown, Iowa, Forente stater, 50158
    - McFarland Clinic PC-Marshalltown
  - Mason City, Iowa, Forente stater, 50401
    - Mercy Medical Center - North Iowa
  - Ottumwa, Iowa, Forente stater, 52501
    - Ottumwa Regional Health Center
  - Sioux City, Iowa, Forente stater, 51101
    - Siouxland Regional Cancer Center
  - Sioux City, Iowa, Forente stater, 51104
    - Saint Luke's Regional Medical Center
  - Sioux City, Iowa, Forente stater, 51104
    - Mercy Medical Center-Sioux City
  - West Des Moines, Iowa, Forente stater, 50266-7700
    - Methodist West Hospital
- Kansas
  - Chanute, Kansas, Forente stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forente stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forente stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Fort Scott, Kansas, Forente stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Independence, Kansas, Forente stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forente stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forente stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forente stater, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forente stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forente stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forente stater, 67114
    - Cancer Center of Kansas - Newton
  - Overland Park, Kansas, Forente stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forente stater, 66213
    - Saint Luke's South Hospital
  - Parsons, Kansas, Forente stater, 67357
    - Cancer Center of Kansas - Parsons
  - Prairie Village, Kansas, Forente stater, 66208
    - Kansas City NCI Community Oncology Research Program
  - Pratt, Kansas, Forente stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forente stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forente stater, 66604
    - Stormont-Vail Regional Health Center
  - Wellington, Kansas, Forente stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forente stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forente stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forente stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forente stater, 67214
    - Wichita NCI Community Oncology Research Program
  - Wichita, Kansas, Forente stater, 67214
    - Via Christi Regional Medical Center
  - Winfield, Kansas, Forente stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Corbin, Kentucky, Forente stater, 40701
    - Baptist Health Corbin
  - Crestview Hills, Kentucky, Forente stater, 41017
    - Oncology Hematology Care Inc-Crestview
  - Elizabethtown, Kentucky, Forente stater, 42701
    - Hardin Memorial Hospital
  - Lexington, Kentucky, Forente stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forente stater, 40207
    - Baptist Health Louisville
  - Madisonville, Kentucky, Forente stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Owensboro, Kentucky, Forente stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
  - Paducah, Kentucky, Forente stater, 42003
    - Baptist Health Paducah
- Louisiana
  - Alexandria, Louisiana, Forente stater, 71301
    - Christus Saint Frances Cabrini Hospital
  - Monroe, Louisiana, Forente stater, 71202
    - University Health-Conway
  - Shreveport, Louisiana, Forente stater, 71103
    - Louisiana State University Health Sciences Center Shreveport
  - Shreveport, Louisiana, Forente stater, 71105
    - CHRISTUS Highland Medical Center
- Maine
  - Augusta, Maine, Forente stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forente stater, 04401
    - Eastern Maine Medical Center
  - Lewiston, Maine, Forente stater, 04240
    - Central Maine Medical Center
  - Rockport, Maine, Forente stater, 04856
    - Penobscot Bay Medical Center
- Maryland
  - Baltimore, Maryland, Forente stater, 21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Bethesda, Maryland, Forente stater, 20814
    - Suburban Hospital
  - Frederick, Maryland, Forente stater, 21701
    - Frederick Memorial Hospital
  - Gaithersburg, Maryland, Forente stater, 20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Largo, Maryland, Forente stater, 20774
    - Kaiser Permanente - Largo Medical Center
- Massachusetts
  - Attleboro, Massachusetts, Forente stater, 02703
    - Sturdy Memorial Hospital
  - Boston, Massachusetts, Forente stater, 02118
    - Boston Medical Center
  - Brighton, Massachusetts, Forente stater, 02135
    - Steward Saint Elizabeth's Medical Center
  - Fall River, Massachusetts, Forente stater, 02721
    - Saint Anne's Hospital
  - Fitchburg, Massachusetts, Forente stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Newton, Massachusetts, Forente stater, 02462
    - Newton-Wellesley Hospital
  - Norwood, Massachusetts, Forente stater, 02062
    - Norwood Hospital
  - Springfield, Massachusetts, Forente stater, 01199
    - Baystate Medical Center
  - Worcester, Massachusetts, Forente stater, 01655
    - University of Massachusetts Medical School
- Michigan
  - Adrian, Michigan, Forente stater, 49221
    - Bixby Medical Center
  - Adrian, Michigan, Forente stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48106-0995
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forente stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forente stater, 48106
    - Michigan Cancer Research Consortium NCORP
  - Battle Creek, Michigan, Forente stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forente stater, 48706
    - McLaren-Bay Region
  - Big Rapids, Michigan, Forente stater, 49307
    - Spectrum Health Big Rapids Hospital
  - Clarkston, Michigan, Forente stater, 48346
    - Great Lakes Cancer Institute
  - Dearborn, Michigan, Forente stater, 48124
    - Beaumont Hospital-Dearborn
  - Detroit, Michigan, Forente stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forente stater, 48236
    - Saint John Hospital and Medical Center
  - Detroit, Michigan, Forente stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Escanaba, Michigan, Forente stater, 49829
    - Green Bay Oncology - Escanaba
  - Farmington Hills, Michigan, Forente stater, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Forente stater, 48502
    - Hurley Medical Center
  - Flint, Michigan, Forente stater, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Forente stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forente stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forente stater, 49503
    - Mercy Health Saint Mary's
  - Grand Rapids, Michigan, Forente stater, 49503
    - Cancer Research Consortium of West Michigan NCORP
  - Iron Mountain, Michigan, Forente stater, 49801
    - Green Bay Oncology - Iron Mountain
  - Jackson, Michigan, Forente stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forente stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forente stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forente stater, 49001
    - Borgess Medical Center
  - Lansing, Michigan, Forente stater, 48912
    - Sparrow Hospital
  - Lansing, Michigan, Forente stater, 48910
    - McLaren-Greater Lansing
  - Livonia, Michigan, Forente stater, 48154
    - Saint Mary Mercy Hospital
  - Midland, Michigan, Forente stater, 48670
    - Mid-Michigan Medical Center - Midland
  - Monroe, Michigan, Forente stater, 48162
    - Mercy Memorial Hospital
  - Monroe, Michigan, Forente stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Mount Clemens, Michigan, Forente stater, 48043
    - McLaren Cancer Institute-Macomb
  - Mount Pleasant, Michigan, Forente stater, 48858
    - McLaren Cancer Institute-Central Michigan
  - Muskegon, Michigan, Forente stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forente stater, 49120
    - Lakeland Community Hospital
  - Petoskey, Michigan, Forente stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forente stater, 48341
    - Saint Joseph Mercy Oakland
  - Port Huron, Michigan, Forente stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forente stater, 49677
    - Spectrum Health Reed City Hospital
  - Royal Oak, Michigan, Forente stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Saginaw, Michigan, Forente stater, 48601
    - Saint Mary's of Michigan
  - Saint Joseph, Michigan, Forente stater, 49085
    - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forente stater, 49085
    - Lakeland Hospital
  - Southfield, Michigan, Forente stater, 48075
    - Providence Hospital-Southfield Cancer Center
  - Traverse City, Michigan, Forente stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forente stater, 48098
    - William Beaumont Hospital - Troy
  - Warren, Michigan, Forente stater, 48093
    - Saint John Macomb-Oakland Hospital
- Minnesota
  - Bemidji, Minnesota, Forente stater, 56601
    - Sanford Clinic North-Bemidgi
  - Brainerd, Minnesota, Forente stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forente stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forente stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forente stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forente stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forente stater, 55435
    - Fairview-Southdale Hospital
  - Fergus Falls, Minnesota, Forente stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forente stater, 55432
    - Unity Hospital
  - Hutchinson, Minnesota, Forente stater, 55350
    - Hutchinson Area Health Care
  - Maplewood, Minnesota, Forente stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forente stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forente stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forente stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forente stater, 55454
    - Health Partners Inc
  - New Ulm, Minnesota, Forente stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forente stater, 55422
    - North Memorial Medical Health Center
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Louis Park, Minnesota, Forente stater, 55416
    - Metro Minnesota Community Oncology Research Consortium
  - Saint Paul, Minnesota, Forente stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forente stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forente stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forente stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forente stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forente stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forente stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
- Mississippi
  - Jackson, Mississippi, Forente stater, 39216
    - University of Mississippi Medical Center
  - Oxford, Mississippi, Forente stater, 38655
    - Family Cancer Center-Oxford
  - Pascagoula, Mississippi, Forente stater, 39581
    - Singing River Hospital
  - Southaven, Mississippi, Forente stater, 38671
    - Family Cancer Center-Southhaven
  - Southhaven, Mississippi, Forente stater, 38671
    - Baptist Memorial Hospital-Desoto
- Missouri
  - Bonne Terre, Missouri, Forente stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forente stater, 65616
    - CoxHealth Cancer Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forente stater, 63703
    - Southeast Cancer Center
  - Columbia, Missouri, Forente stater, 65212
    - University of Missouri - Ellis Fischel
  - Independence, Missouri, Forente stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forente stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Joplin, Missouri, Forente stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forente stater, 64804
    - Mercy Hospital-Joplin
  - Kansas City, Missouri, Forente stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forente stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forente stater, 64118
    - Heartland Hematology and Oncology Associates Incorporated
  - Lee's Summit, Missouri, Forente stater, 64086
    - Saint Luke's East - Lee's Summit
  - Liberty, Missouri, Forente stater, 64068
    - Liberty Radiation Oncology Center
  - Rolla, Missouri, Forente stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forente stater, 65401
    - Saint John's Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forente stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forente stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forente stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forente stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Sainte Genevieve, Missouri, Forente stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Cancer Research for the Ozarks NCORP
  - Springfield, Missouri, Forente stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forente stater, 65804
    - Mercy Hospital Springfield
  - Sullivan, Missouri, Forente stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forente stater, 63127
    - Missouri Baptist Outpatient Center-Sunset Hills
- Montana
  - Billings, Montana, Forente stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forente stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forente stater, 59101
    - Montana Cancer Consortium NCORP
  - Bozeman, Montana, Forente stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forente stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forente stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Helena, Montana, Forente stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forente stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forente stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forente stater, 59802
    - Saint Patrick Hospital - Community Hospital
  - Missoula, Montana, Forente stater, 59802
    - Montana Cancer Specialists
- Nebraska
  - Kearney, Nebraska, Forente stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forente stater, 68506
    - Nebraska Hematology and Oncology
  - Lincoln, Nebraska, Forente stater, 68510
    - Nebraska Cancer Research Center
  - Lincoln, Nebraska, Forente stater, 68510
    - Southeast Nebraska Cancer Center
  - Norfolk, Nebraska, Forente stater, 68701
    - Faith Regional Medical Offices West
  - North Platte, Nebraska, Forente stater, 69103
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, Forente stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forente stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forente stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forente stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forente stater, 68106
    - Missouri Valley Cancer Consortium
  - Omaha, Nebraska, Forente stater, 68130
    - Oncology Hematology West PC
  - Omaha, Nebraska, Forente stater, 68130
    - Urology Cancer Center PC
  - Omaha, Nebraska, Forente stater, 68124
    - Oncology Hematology West
  - Scottsbluff, Nebraska, Forente stater, 69361
    - Regional West Medical Center
- Nevada
  - Henderson, Nevada, Forente stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forente stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forente stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forente stater, 89074
    - 21st Century Oncology - Henderson
  - Las Vegas, Nevada, Forente stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forente stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forente stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forente stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forente stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forente stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forente stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forente stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forente stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forente stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forente stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forente stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forente stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forente stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forente stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forente stater, 89109
    - 21st Century Oncology
  - Las Vegas, Nevada, Forente stater, 89148
    - Cancer and Blood Specialists-Fort Apache
  - Las Vegas, Nevada, Forente stater, 89106
    - Nevada Cancer Research Foundation CCOP
  - Las Vegas, Nevada, Forente stater, 89148
    - 21st Century Oncology - Fort Apache
  - Las Vegas, Nevada, Forente stater, 89182
    - 21st Century Oncology - Vegas Tenaya
  - Reno, Nevada, Forente stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forente stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forente stater, 89503
    - Alpine Hematology-Oncology
  - Reno, Nevada, Forente stater, 89519
    - Reno Oncology Consultants
- New Hampshire
  - Dover, New Hampshire, Forente stater, 03820
    - Wentworth-Douglass Hospital
  - Portsmouth, New Hampshire, Forente stater, 03802
    - Portsmouth Regional Hospital
- New Jersey
  - Egg Harbor Township, New Jersey, Forente stater, 08234
    - AtlantiCare Surgery Center
  - New Brunswick, New Jersey, Forente stater, 08901
    - Saint Peter's University Hospital
  - Newark, New Jersey, Forente stater, 07112
    - Newark Beth Israel Medical Center
  - Pennington, New Jersey, Forente stater, 08534
    - Capital Health Medical Center-Hopewell
  - Vineland, New Jersey, Forente stater, 08360
    - Inspira Medical Center Vineland
  - Woodbury, New Jersey, Forente stater, 08096
    - Inspira Medical Center Woodbury
- New Mexico
  - Albuquerque, New Mexico, Forente stater, 87102
    - University of New Mexico Cancer Center
- New York
  - Auburn, New York, Forente stater, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Bronx, New York, Forente stater, 10451
    - Lincoln Medical and Mental Health Center
  - Buffalo, New York, Forente stater, 14263
    - Roswell Park Cancer Institute
  - Cooperstown, New York, Forente stater, 13326
    - Mary Imogene Bassett Hospital
  - East Syracuse, New York, Forente stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Elmhurst, New York, Forente stater, 11373
    - Elmhurst Hospital Center
  - Elmira, New York, Forente stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Jamaica, New York, Forente stater, 11432
    - Queens Hospital Center
  - Middletown, New York, Forente stater, 10940
    - Orange Regional Medical Center
  - New York, New York, Forente stater, 10032
    - Columbia University/Herbert Irving Cancer Center
  - Rochester, New York, Forente stater, 14642
    - University of Rochester
  - Rochester, New York, Forente stater, 14620
    - Highland Hospital
  - Rome, New York, Forente stater, 13440
    - Hematology Oncology Associates of Central New York-Rome
  - Staten Island, New York, Forente stater, 10305
    - Staten Island University Hospital
  - Syracuse, New York, Forente stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forente stater, 13215
    - Hematology Oncology Associates of Central New York-Onondaga Hill
  - White Plains, New York, Forente stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Asheboro, North Carolina, Forente stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forente stater, 28816
    - Hope Women's Cancer Centers-Asheville
  - Asheville, North Carolina, Forente stater, 28801
    - Cancer Care of Western North Carolina
  - Asheville, North Carolina, Forente stater, 28801
    - Mission Hospital-Memorial Campus
  - Belmont, North Carolina, Forente stater, 28012
    - Gaston Hematology and Oncology Associates-Belmont
  - Clinton, North Carolina, Forente stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Gastonia, North Carolina, Forente stater, 28054
    - CaroMont Regional Medical Center
  - Gastonia, North Carolina, Forente stater, 28054
    - Gaston Hematology and Oncology Associates
  - Goldsboro, North Carolina, Forente stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forente stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forente stater, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Forente stater, 28791
    - Hendersonville Hematology and Oncology at Pardee
  - Hendersonville, North Carolina, Forente stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forente stater, 28792
    - Park Ridge Hospital Breast Health Center
  - Jacksonville, North Carolina, Forente stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kernersville, North Carolina, Forente stater, 27284
    - Novant Health Oncology Specialists-Kernersville
  - Kinston, North Carolina, Forente stater, 28501
    - Kinston Medical Specialists PA
  - Leland, North Carolina, Forente stater, 28451
    - Cape Fear Cancer Specialists-Leland
  - Mount Airy, North Carolina, Forente stater, 27030
    - Novant Health Oncology Specialists-Mount Airy
  - Pinehurst, North Carolina, Forente stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hosiptal
  - Reidsville, North Carolina, Forente stater, 27320
    - Annie Penn Memorial Hospital
  - Salisbury, North Carolina, Forente stater, 28144
    - Carolina Oncology Associates PA
  - Shelby, North Carolina, Forente stater, 28150
    - Cleveland Hematology and Oncology Associates PC
  - Statesville, North Carolina, Forente stater, 28677
    - Iredell Memorial Hospital
  - Statesville, North Carolina, Forente stater, 28625
    - Novant Health Oncology Specialists-Statesville
  - Thomasville, North Carolina, Forente stater, 27360
    - Novant Health Oncology Specialists-Davidson County
  - Washington, North Carolina, Forente stater, 27889
    - Marion L Shepard Cancer Center at Vidant Beaufort Hospital
  - Wilkesboro, North Carolina, Forente stater, 28659
    - Novant Health Oncology Specialists-Wilkesboro
  - Wilmington, North Carolina, Forente stater, 28401
    - New Hanover Regional Medical Center/Zimmer Cancer Center
  - Wilmington, North Carolina, Forente stater, 28401
    - Cape Fear Cancer Specialists
  - Wilson, North Carolina, Forente stater, 27893
    - Southeastern Medical Oncology Center-Wilson
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Novant Health Forsyth Medical Center
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Novant Health Oncology Specialists
  - Winston-Salem, North Carolina, Forente stater, 27103
    - Winston-Salem Health Care
  - Winston-Salem, North Carolina, Forente stater, 27104
    - Southeast Clinical Oncology Research (SCOR) Consortium NCORP
- North Dakota
  - Bismarck, North Dakota, Forente stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forente stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Clinic North-Fargo
  - Fargo, North Dakota, Forente stater, 58122
    - Sanford Medical Center-Fargo
  - Fargo, North Dakota, Forente stater, 58122
    - Roger Maris Cancer Center
  - Grand Forks, North Dakota, Forente stater, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Forente stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Akron, Ohio, Forente stater, 44307
    - Akron General Medical Center
  - Belpre, Ohio, Forente stater, 45714
    - Strecker Cancer Center-Belpre
  - Bowling Green, Ohio, Forente stater, 43402
    - Toledo Clinic Cancer Centers-Bowling Green
  - Chillicothe, Ohio, Forente stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forente stater, 45242
    - Oncology Hematology Care Inc-Blue Ash
  - Cincinnati, Ohio, Forente stater, 45202
    - Oncology Hematology Care Inc-Eden Park
  - Cincinnati, Ohio, Forente stater, 45211
    - Oncology Hematology Care Inc-Mercy West
  - Cincinnati, Ohio, Forente stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forente stater, 45230
    - Oncology Hematology Care Inc - Anderson
  - Columbus, Ohio, Forente stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forente stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forente stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forente stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forente stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forente stater, 43222
    - Mount Carmel Health Center West
  - Columbus, Ohio, Forente stater, 43215
    - Columbus NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forente stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forente stater, 45415
    - Samaritan North Health Center
  - Dayton, Ohio, Forente stater, 45420
    - Dayton NCI Community Oncology Research Program
  - Dayton, Ohio, Forente stater, 45405
    - Grandview Hospital
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forente stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forente stater, 43015
    - Grady Memorial Hospital
  - Fairfield, Ohio, Forente stater, 45014
    - Oncology Hematology Care Inc-Healthplex
  - Findlay, Ohio, Forente stater, 45840
    - Blanchard Valley Hospital
  - Franklin, Ohio, Forente stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forente stater, 45331
    - Wayne Hospital
  - Kettering, Ohio, Forente stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Fairfield Medical Center
  - Lancaster, Ohio, Forente stater, 43130
    - Lancaster Radiation Oncology
  - Lima, Ohio, Forente stater, 45801
    - Saint Rita's Medical Center
  - Lima, Ohio, Forente stater, 45804
    - Lima Memorial Hospital
  - Marietta, Ohio, Forente stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forente stater, 43302
    - OneHealth Marion General Hospital
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forente stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Mount Vernon, Ohio, Forente stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forente stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forente stater, 43055
    - Newark Radiation Oncology
  - Oregon, Ohio, Forente stater, 43616
    - Saint Charles Hospital
  - Oregon, Ohio, Forente stater, 43616
    - Toledo Clinic Cancer Centers-Oregon
  - Portsmouth, Ohio, Forente stater, 45662
    - Southern Ohio Medical Center
  - Springfield, Ohio, Forente stater, 45505
    - Springfield Regional Medical Center
  - Sylvania, Ohio, Forente stater, 43560
    - Flower Hospital
  - Tiffin, Ohio, Forente stater, 44883
    - Mercy Hospital of Tiffin
  - Toledo, Ohio, Forente stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forente stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forente stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forente stater, 43617
    - Toledo Community Hospital Oncology Program CCOP
  - Toledo, Ohio, Forente stater, 43606
    - The Toledo Hospital/Toledo Children's Hospital
  - Toledo, Ohio, Forente stater, 43623
    - Mercy Saint Anne Hospital
  - Troy, Ohio, Forente stater, 45373
    - Upper Valley Medical Center
  - Wauseon, Ohio, Forente stater, 43567
    - Fulton County Health Center
  - Westerville, Ohio, Forente stater, 43081
    - Saint Ann's Hospital
  - Xenia, Ohio, Forente stater, 45385
    - Greene Memorial Hospital
  - Zanesville, Ohio, Forente stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Tulsa, Oklahoma, Forente stater, 74136
    - Natalie Warren Bryant Cancer Center at Saint Francis
  - Tulsa, Oklahoma, Forente stater, 74146
    - Warren Clinic Oncology-Tulsa
- Oregon
  - Clackamas, Oregon, Forente stater, 97015
    - Clackamas Radiation Oncology Center
  - Corvallis, Oregon, Forente stater, 97330
    - Good Samaritan Hospital
  - Milwaukie, Oregon, Forente stater, 97222
    - Providence Milwaukie Hospital
  - Newberg, Oregon, Forente stater, 97132
    - Providence Newberg Medical Center
  - Oregon City, Oregon, Forente stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forente stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forente stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forente stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forente stater, 97227
    - Kaiser Permanente Northwest
- Pennsylvania
  - Allentown, Pennsylvania, Forente stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Danville, Pennsylvania, Forente stater, 17822
    - Geisinger Medical Center
  - Doylestown, Pennsylvania, Forente stater, 18901
    - Doylestown Hospital
  - Easton, Pennsylvania, Forente stater, 18042
    - Easton Hospital
  - Hazleton, Pennsylvania, Forente stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forente stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Lewisburg, Pennsylvania, Forente stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forente stater, 17044
    - Lewistown Hospital
  - Meadowbrook, Pennsylvania, Forente stater, 19046
    - Holy Redeemer Hospital and Medical Center
  - Phoenixville, Pennsylvania, Forente stater, 19460
    - Phoenixville Hospital
  - Pottstown, Pennsylvania, Forente stater, 19464
    - Pottstown Memorial Medical Center
  - Pottsville, Pennsylvania, Forente stater, 17901
    - Geisinger Medical Oncology-Pottsville
  - State College, Pennsylvania, Forente stater, 16801
    - Geisinger Medical Group
  - West Chester, Pennsylvania, Forente stater, 19380
    - Chester County Hospital
  - West Reading, Pennsylvania, Forente stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forente stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forente stater, 17701
    - Susquehanna Cancer Center
- South Carolina
  - Anderson, South Carolina, Forente stater, 29621
    - AnMed Health Cancer Center
  - Beaufort, South Carolina, Forente stater, 29902
    - Beaufort Memorial Hospital
  - Charleston, South Carolina, Forente stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forente stater, 29403
    - Charleston Hematology Oncology Associates-Roper
  - Charleston, South Carolina, Forente stater, 29406
    - Lowcountry Hematology Oncology PA-North Charleston
  - Charleston, South Carolina, Forente stater, 29414
    - Charleston Hematology Oncology Associates PA-St. Francis
  - Charleston, South Carolina, Forente stater, 29414
    - Lowcountry Hematology Oncology PA-West Ashley
  - Easley, South Carolina, Forente stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Florence, South Carolina, Forente stater, 29506
    - McLeod Regional Medical Center
  - Greenville, South Carolina, Forente stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Andrews
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forente stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greenville, South Carolina, Forente stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greenwood, South Carolina, Forente stater, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Forente stater, 29651
    - Gibbs Cancer Center-Pelham
  - Greer, South Carolina, Forente stater, 29650
    - Greenville Health System Cancer Institute-Greer
  - Mount Pleasant, South Carolina, Forente stater, 29464
    - Lowcountry Hematology Oncology PA-Mount Pleasant
  - Seneca, South Carolina, Forente stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forente stater, 29303
    - Spartanburg Medical Center
  - Spartanburg, South Carolina, Forente stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
- South Dakota
  - Rapid City, South Dakota, Forente stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forente stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forente stater, 57104
    - Sanford Cancer Center-Oncology Clinic
- Tennessee
  - Bartlett, Tennessee, Forente stater, 38133
    - Boston Baskin Cancer Center-Bartlett
  - Memphis, Tennessee, Forente stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Forente stater, 38120
    - Family Cancer Center-Memphis
- Texas
  - Amarillo, Texas, Forente stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - El Paso, Texas, Forente stater, 79905
    - Texas Technology University
  - Laredo, Texas, Forente stater, 78041
    - Doctor's Hospital of Laredo
- Utah
  - American Fork, Utah, Forente stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forente stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forente stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forente stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forente stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forente stater, 84604
    - Utah Valley Regional Medical Center
  - Saint George, Utah, Forente stater, 84770
    - Dixie Medical Center Regional Cancer Center
  - Salt Lake City, Utah, Forente stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forente stater, 84143
    - LDS Hospital
- Vermont
  - Berlin, Vermont, Forente stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forente stater, 05405
    - University of Vermont College of Medicine
- Virginia
  - Burke, Virginia, Forente stater, 22015
    - Kaiser Permanente-Burke Medical Center
  - Charlottesville, Virginia, Forente stater, 22901
    - Sentara Martha Jefferson Hospital
  - Fairfax, Virginia, Forente stater, 22031
    - IMG Hematology Oncology 8501
  - Fredericksburg, Virginia, Forente stater, 22401
    - Fredericksburg Oncology Inc
  - McLean, Virginia, Forente stater, 22102
    - Kaiser Permanente Tysons Corner Medical Center
  - Midlothian, Virginia, Forente stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Richmond, Virginia, Forente stater, 23226
    - Bon Secours Saint Mary's Hospital
- Washington
  - Anacortes, Washington, Forente stater, 98221
    - Cancer Care Center at Island Hospital
  - Auburn, Washington, Forente stater, 98001
    - MultiCare Auburn Medical Center
  - Bainbridge Island, Washington, Forente stater, 98110
    - Virginia Mason Bainbridge Island Medical Center
  - Bellevue, Washington, Forente stater, 98004
    - Overlake Hospital Medical Center
  - Bellingham, Washington, Forente stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forente stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Burien, Washington, Forente stater, 98166
    - Highline Medical Center-Main Campus
  - Edmonds, Washington, Forente stater, 98026
    - Swedish Medical Center-Edmonds
  - Federal Way, Washington, Forente stater, 98002
    - Virginia Mason Federal Way Medical Center
  - Gig Harbor, Washington, Forente stater, 98332
    - Tacoma/Valley Radiation Oncology Centers-Gig Harbor
  - Gig Harbor, Washington, Forente stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forente stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forente stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kennewick, Washington, Forente stater, 99336
    - Northwest Cancer Clinic
  - Longview, Washington, Forente stater, 98632
    - PeaceHealth Saint John Medical Center
  - Lynnwood, Washington, Forente stater, 98036
    - Virginia Mason Lynnwood Medical Center
  - Mount Vernon, Washington, Forente stater, 98274
    - Skagit Valley Hospital
  - Poulsbo, Washington, Forente stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Poulsbo, Washington, Forente stater, 98370
    - Peninsula Cancer Center
  - Puyallup, Washington, Forente stater, 98372
    - MultiCare Good Samaritan Hospital
  - Puyallup, Washington, Forente stater, 98372
    - Tacoma/Valley Radiation Oncology Centers-Puyallup
  - Seattle, Washington, Forente stater, 98109
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forente stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forente stater, 98104
    - Harborview Medical Center
  - Seattle, Washington, Forente stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forente stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forente stater, 98104
    - Minor and James Medical PLLC
  - Seattle, Washington, Forente stater, 98112
    - Group Health Cooperative-Seattle
  - Seattle, Washington, Forente stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Sedro-Woolley, Washington, Forente stater, 98284
    - United General Hospital
  - Spokane, Washington, Forente stater, 99218
    - Evergreen Hematology and Oncology PS
  - Spokane, Washington, Forente stater, 99202
    - Cancer Care Northwest - Spokane South
  - Tacoma, Washington, Forente stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forente stater, 98405
    - Tacoma/Valley Radiation Oncology Centers-Saint Joe's
  - Tacoma, Washington, Forente stater, 97405
    - Tacoma/Valley Radiation Oncology Centers-Jackson Hall
  - Tacoma, Washington, Forente stater, 98405
    - Northwest NCI Community Oncology Research Program
  - Vancouver, Washington, Forente stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forente stater, 98684
    - Compass Oncology Vancouver
  - Wenatchee, Washington, Forente stater, 98801
    - Wenatchee Valley Hospital and Clinics
- Wisconsin
  - Antigo, Wisconsin, Forente stater, 54409
    - Langlade Hospital and Cancer Center
  - Chippewa Falls, Wisconsin, Forente stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forente stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Fond Du Lac, Wisconsin, Forente stater, 54935
    - Saint Agnes Hospital/Agnesian Cancer Center
  - Green Bay, Wisconsin, Forente stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forente stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Green Bay, Wisconsin, Forente stater, 54303
    - Green Bay Oncology Limited at Saint Mary's Hospital
  - Green Bay, Wisconsin, Forente stater, 54301-3526
    - Green Bay Oncology at Saint Vincent Hospital
  - Janesville, Wisconsin, Forente stater, 53547
    - Mercy Health System
  - La Crosse, Wisconsin, Forente stater, 54601
    - Gundersen Lutheran Medical Center
  - Manitowoc, Wisconsin, Forente stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forente stater, 54143
    - Bay Area Medical Center
  - Marshfield, Wisconsin, Forente stater, 54449
    - Marshfield Clinic
  - Milwaukee, Wisconsin, Forente stater, 53210
    - Wheaton Franciscan Healthcare - Saint Joseph
  - Minocqua, Wisconsin, Forente stater, 54548
    - Marshfield Clinic-Minocqua Center
  - New Richmond, Wisconsin, Forente stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconto Falls, Wisconsin, Forente stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Rhinelander, Wisconsin, Forente stater, 54501
    - Marshfield Clinic at James Beck Cancer Center
  - Rice Lake, Wisconsin, Forente stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forente stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forente stater, 54481
    - Marshfield Clinic Cancer Care at Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forente stater, 54235
    - Green Bay Oncology - Sturgeon Bay
  - Wausau, Wisconsin, Forente stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forente stater, 54401
    - Marshfield Clinic-Wausau Center
  - Weston, Wisconsin, Forente stater, 54476
    - Marshfield Clinic - Weston Center
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forente stater, 54494
    - Aspirus UW Cancer Center
- Wyoming
  - Casper, Wyoming, Forente stater, 82609
    - Rocky Mountain Oncology
  - Cheyenne, Wyoming, Forente stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forente stater, 82414
    - Big Horn Basin Cancer Center
  - Cody, Wyoming, Forente stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forente stater, 82801
    - Welch Cancer Center

Deltakelseskriterier

Forskere ser etter personer som passer til en bestemt beskrivelse, kalt kvalifikasjonskriterier. Noen eksempler på disse kriteriene er en persons generelle helsetilstand eller tidligere behandlinger.

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Ikke eldre enn 120 år (VOKSEN, OLDER_ADULT, BARN)

Tar imot friske frivillige

Nei

Kjønn som er kvalifisert for studier

Hunn

Beskrivelse

SYKDOMENS KARAKTERISTIKA:

Pasienter må være kvinner med histologisk bekreftet østrogenreseptor (ER)- og/eller progesteronreseptor (PgR)-positivt invasivt brystkarsinom uten tegn på metastatisk sykdom (M0)
Pasienter må ha fullført mastektomi eller brystsparende operasjon og må ha kommet seg etter alle bivirkninger av operasjonen
Pasienter må ha aromatasehemmer-assosierte muskel-skjelettsymptomer som begynte eller økte etter oppstart av AI-behandling; nye muskel- og skjelettsmerter må ikke skyldes spesifikt brudd eller traumatisk skade
Pasienter må ha fylt ut S1202 Brief Pain Inventory-Short Form (BPI-SF) innen 7 dager før registrering; pasienter må ha en "gjennomsnittlig smerte" på minst 4 på BPI-SF

PASIENT KARAKTERISTIKA:

Pasienter må være postmenopausale, som definert av minst ett av følgende:
- Minst 12 måneder siden siste menstruasjon
- Tidligere bilateral ooforektomi
- Tidligere hysterektomi med en eller begge eggstokkene på plass (eller tidligere hysterektomi der dokumentasjon av bilateral oophorektomi er utilgjengelig) OG follikkelstimulerende hormon (FSH) verdier i samsvar med de institusjonelle normale verdiene for postmenopausal tilstand; hvis pasienten er under 55 år, må FSH-nivåer oppnås innen 28 dager før registrering ELLER
- Har vært på LHRH-agonistbehandling i minst 3 måneder og østradiolnivåer tatt innen 28 dager før registrering stemmer overens med de institusjonelle normalverdiene for postmenopausal tilstand.
Pasienter må ha Zubrod ytelsesstatus på 0-2
Pasienter må ikke ha noen kjent allergi eller overfølsomhet overfor duloksetin eller noen av de inaktive ingrediensene i den matchende placeboen
Pasienter må ikke ha noen kontraindiserte samtidige sykdommer oppført på pakningsvedlegget for duloksetin, inkludert:
- Gjeldende primærpsykiatrisk diagnose (schizofreni, psykose) eller selvmordstanker, bipolar lidelse i anamnesen eller anfallsforstyrrelse
- Anamnese med alkohol eller annet rusmisbruk eller avhengighet innen 365 dager før registrering
- Kronisk leversykdom
- Sluttstadium nyresykdom
- Ukontrollert trangvinklet glaukom
- Klinisk signifikant koagulasjonsforstyrrelse
Kreatininclearance > 30 ml/min
Aspartataminotransferase (AST) og alaninaminotransferase (ALT) begge innenfor 3 x øvre normalgrense
Totalt bilirubin innenfor øvre normalgrense
Pasienter må kunne fylle ut spørreskjemaer på engelsk eller spansk
Pasienter må ikke ha samtidig medisinsk/artrittsykdom som kan forvirre eller forstyrre evaluering av smerte eller effekt, inkludert: inflammatorisk leddgikt (revmatoid artritt, systemisk lupus, spondyloartropati, psoriasisartritt, polymyalgia rheumatica) eller kreft som involverer beinet
Pasienter må være villige til å sende inn blodprøver for korrelative studier; baseline prøver må innhentes før protokollbehandling påbegynnes

FØR SAMTIDIG TERAPI:

Se Sykdomskarakteristikker
Hvis pasienter ble behandlet med kjemoterapi og/eller strålebehandling, må disse behandlingene fullføres minst 28 dager før studieregistrering
Samtidig behandling med bisfosfonat og trastuzumab er tillatt
Pasienter bør ha kommet seg etter alle grad 2 eller høyere bivirkninger av kjemoterapi og/eller strålebehandling med unntak av alopecia og perifer nevropati
Pasienter må for øyeblikket ta en av følgende aromatasehemmerdoser (AI) i minst 21 dager, men ikke lenger enn 12 måneder, før registrering og planlegger å fortsette i minst ytterligere 180 dager etter registrering
- Anastrozol (Arimidex®) 1 mg daglig
- Letrozol (Femara®) 2,5 mg daglig
- Exemestan (Aromasin®) 25 mg daglig
Pasienter må ikke ta noen kontraindiserte medisiner oppført på pakningsvedlegget for duloksetin, inkludert følgende: behandling med fentiaziner, propafenon, flekainid eller linezolid; behandling med monoaminoksidase (MAO)-hemmer innen 14 dager før registrering; eller nåværende bruk av antikoagulasjonsmedisiner (f.eks. heparin, warfarin)
Pasienter må ikke kreve selektive serotoninreopptakshemmere (SSRI), serotonin- og noradrenalin reopptakshemmere (SNRI) eller trisykliske antidepressiva under studiedeltakelse; pasienter må ha vært i stand til å trappe ned og avslutte behandlingen med disse medisinene minst 7 dager før registrering; Pasienter må ikke ha tatt duloksetin eller milnacipran innen 90 dager før registrering
Pasienter som får behandling med narkotika, tramadol, gabapentin og/eller pregabalin må ha tatt en stabil dose i minst 30 dager før registrering.

Studieplan

Denne delen gir detaljer om studieplanen, inkludert hvordan studien er utformet og hva studien måler.

Hvordan er studiet utformet?

Designdetaljer

Primært formål: BEHANDLING
Tildeling: TILFELDIG
Intervensjonsmodell: PARALLELL
Masking: TRIPLE

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm	Intervensjon / Behandling
EKSPERIMENTELL: Arm I Pasienter får duloksetinhydroklorid oralt (PO) én gang daglig (QD) på dag 1-7, to ganger daglig (BID) på dag 8-84, og deretter QD på dag 85-91.	Legemiddel: duloksetinhydroklorid Gitt PO Andre navn: NSC-744012
PLACEBO_COMPARATOR: Arm II Pasienter får placebo PO QD på dag 1-7, BID på dag 8-84, og deretter QD på dag 85-91.	Annen: placebo Gitt PO

Hva måler studien?

Primære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Gjennomsnittlig leddsmerter i henhold til BPI-SF Tidsramme: Uke 2, 6, 12 og 24; Uke 12 rapportert	Gjennomsnittlig leddsmerter i henhold til Brief Pain Inventory - Short Form (BPI-SF) gjennomsnittlig smertescore (element #4). Dette elementet har en skala fra 0 til 10 med 0 som indikerer "Ingen smerte" og 10 indikerer "Smerte så ille som du kan forestille deg".	Uke 2, 6, 12 og 24; Uke 12 rapportert

Sekundære resultatmål

Resultatmål	Tiltaksbeskrivelse	Tidsramme
Verste leddsmerter ifølge BPI-SF Tidsramme: Uke 2, 6, 12 og 24; Uke 12 rapportert	Verste leddsmerter i henhold til BPI-SF verste smertescore (punkt #2). Dette elementet har en skala fra 0 til 10 med 0 som indikerer "Ingen smerte" og 10 indikerer "Smerte så ille som du kan forestille deg".	Uke 2, 6, 12 og 24; Uke 12 rapportert
Smerteinterferens I henhold til BPI-SF Tidsramme: Uke 2, 6, 12 og 24; Uke 12 rapportert	Smerteforstyrrelser i henhold til BPI-SF: dette elementet har en skala fra 0 til 10 med 0 som indikerer "Forstyrrer ikke" og 10 som indikerer "Forstyrrer fullstendig".	Uke 2, 6, 12 og 24; Uke 12 rapportert

Samarbeidspartnere og etterforskere

Det er her du vil finne personer og organisasjoner som er involvert i denne studien.

Sponsor

Southwest Oncology Group

Samarbeidspartnere

National Cancer Institute (NCI)

Etterforskere

Hovedetterforsker: N. Lynn Henry, MD, PhD, University of Michigan Rogel Cancer Center

Publikasjoner og nyttige lenker

Den som er ansvarlig for å legge inn informasjon om studien leverer frivillig disse publikasjonene. Disse kan handle om alt relatert til studiet.

Generelle publikasjoner

Henry NL, Unger JM, Schott AF, Fehrenbacher L, Flynn PJ, Prow DM, Sharer CW, Burton GV, Kuzma CS, Moseley A, Lew DL, Fisch MJ, Moinpour CM, Hershman DL, Wade JL 3rd. Randomized, Multicenter, Placebo-Controlled Clinical Trial of Duloxetine Versus Placebo for Aromatase Inhibitor-Associated Arthralgias in Early-Stage Breast Cancer: SWOG S1202. J Clin Oncol. 2018 Feb 1;36(4):326-332. doi: 10.1200/JCO.2017.74.6651. Epub 2017 Nov 14.

Studierekorddatoer

Disse datoene sporer fremdriften for innsending av studieposter og sammendragsresultater til ClinicalTrials.gov. Studieposter og rapporterte resultater gjennomgås av National Library of Medicine (NLM) for å sikre at de oppfyller spesifikke kvalitetskontrollstandarder før de legges ut på det offentlige nettstedet.

Studer hoveddatoer

Studiestart (FAKTISKE)

15. mai 2013

Primær fullføring (FAKTISKE)

1. desember 2016

Studiet fullført (FAKTISKE)

20. desember 2018

Datoer for studieregistrering

Først innsendt

11. mai 2012

Først innsendt som oppfylte QC-kriteriene

11. mai 2012

Først lagt ut (ANSLAG)

15. mai 2012

Oppdateringer av studieposter

Sist oppdatering lagt ut (FAKTISKE)

16. desember 2022

Siste oppdatering sendt inn som oppfylte QC-kriteriene

14. desember 2022

Sist bekreftet

1. desember 2022

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

S1202 (ANNEN: SWOG)
U10CA037429 (U.S. NIH-stipend/kontrakt)
NCI-2012-01960 (ANNEN: NCI)

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

IPD-planbeskrivelse

https://swog.org/Visitors/Download/Policies/Policy43.pdf

Studiedata/dokumenter

Datasett for individuell deltaker
Informasjonskommentarer: Data tilgjengelig: Velg individuelle pasientnivådata fra denne studien kan bes om fra NCTN/NCORP Data Archive.

Denne informasjonen ble hentet direkte fra nettstedet clinicaltrials.gov uten noen endringer. Hvis du har noen forespørsler om å endre, fjerne eller oppdatere studiedetaljene dine, vennligst kontakt register@clinicaltrials.gov. Så snart en endring er implementert på clinicaltrials.gov, vil denne også bli oppdatert automatisk på nettstedet vårt. .

Kliniske studier på Smerte

East Carolina University

Tilbaketrukket

Fenotyping av akutt smerte for oppdagelsesforskning og rettet terapi

Post op Pain

Forente stater
Wake Forest University Health Sciences

Rekruttering

Immersive Healing: Therapeutic Potential of Virtual Reality

Phantom Limb Pain (PLP)

Forente stater
Cairo University

Fullført

Effekt av sjokkbølgeterapi på cervikal myofascial syndrom hos ammende kvinner

Cervical Myofascial Pain Syndrome

Egypt
Dilşad Sindel

Fullført

Undersøkelse av effektiviteten av muskelhemming og plasskorreksjonsteknikker for kinesiotapingmetoden hos kvinnelige pasienter med myofascialt smertesyndrom relatert til øvre trapezius aktive triggerpunkter

Kvinnelige pasienter med Myofascial Pain Syndrome (MPS) relatert til øvre Trapezius Active Trigger Points (TP)
Brugmann University Hospital

Tilbaketrukket

En prøve med lidokainplaster for amputasjonssmerter i underekstremiteter

Phantom Limb Pain (PLP) | Primær/sekundær arrhyperalgesi

Belgia
Oslo University Hospital
University of Oslo; Fysiofondet; Oslo Metropolitan University

Rekruttering

HIP-selvledelsesstudien (HIPS)

Gluteal tendinopati | Trochanterisk bursitt | Lateral hoftesmerter | GTPS - Greater Trochanteric Pain Syndrome

Norge
University of Jazan

Rekruttering

Innflytelsen av kroppsmasseindeks og smarttelefonoverbruk på cervikal myofascial smerte: en tverrsnittsstudie

Overvekt | Kroppsvekt | Smarttelefonavhengighet | Cervical Myofascial Pain Syndrome

Saudi-Arabia
Mustafa Kemal University

Rekruttering

Myofascial smertesyndrom og dekstroseproloterapi

Effekten av Dextrose Prolotherapy i Myofascial Pain Syndrome

Tyrkia
University Hospitals, Leicester

Fullført

Abdominal Plane Blocks (APB) ved kroniske magesmerter (CAP)

Magesmerter | Abdominal Myofascial Pain Syndrome (AMPS) | Abdominal Plane Blocks (APB)

Storbritannia
Yuzuncu Yıl University

Fullført

Sammenlignende evaluering av effektiviteten av diklofenaknatrium versus vitamin D-tilskudd på symptomer hos personer med myofascial smerte og vitamin D-mangel

Myofascial Pain Dysfunction Syndrome, Temporomandibulært ledd

Tyrkia

Kliniske studier på placebo

Galderma R&D

Fullført

Effekt av CD07805/47 Gel i Rosacea Flushing

Rosacea

Tyskland
SamA Pharmaceutical Co., Ltd

Ukjent

Kliniske studier for å vurdere effektiviteten og sikkerheten til HLIM

Akutt bronkitt | Akutt øvre luftveisinfeksjon

Korea, Republikken
National Institute on Drug Abuse (NIDA)

Fullført

Effekter av administrasjonsveier for cannabis på menneskelig ytelse og farmakokinetikk

Cannabisbruk

Forente stater
AstraZeneca
Parexel; Spandauer Damm 130; 14050; Berlin, Germany

Fullført

Vurdering av sikkerhet, tolerabilitet og farmakodynamikk etter administrering av én dose AZD8601 til mannlige pasienter med type II diabetes mellitus (T2DM)

Mannlige personer med type II diabetes (T2DM)

Tyskland
Heptares Therapeutics Limited

Fullført

Farmakokinetikk av oral kapsel hos sunne japanske vs. kaukasiske personer (HTL0018318)

Farmakokinetikk | Sikkerhetsproblemer

Storbritannia
Texas A&M University
Nutrabolt

Fullført

Glycemic Response of a Commercial Food Bar (NB16)

Glucose and Insulin Response
Longeveron Inc.

Avsluttet

Allogeneic hMSC Injection in Patients With Hypoplastic Left Heart Syndrome (ELPIS)

Hypoplastisk venstre hjertesyndrom

Forente stater
Regado Biosciences, Inc.

Fullført

Safety, Tolerability and PK/PD of RB006 in a Healthy Volunteer SAD (SC101)

Frivillig frisk

Forente stater
Italfarmaco

Fullført

Klinisk studie for å evaluere effektiviteten og sikkerheten til Givinostat hos ambulante pasienter med Becker muskeldystrofi

Becker muskeldystrofi

Nederland, Italia
West Penn Allegheny Health System

Fullført

Sunovion Growth Study Pediatriske personer med mild astma og allergisk rhinitt

Astma | Allergisk rhinitt

Forente stater

S1202: Duloksetinhydroklorid for muskel-/leddsmerter i tidlig stadium av brystkreft som får hormonbehandling

En randomisert placebokontrollert fase III-studie av duloksetin for behandling av aromatasehemmer-assosierte muskel- og skjelettsymptomer hos kvinner med tidlig brystkreft

Studieoversikt

Status

Forhold

Intervensjon / Behandling

Detaljert beskrivelse

Studietype

Registrering (Faktiske)

Fase

Kontakter og plasseringer

Studiesteder

Deltakelseskriterier

Kvalifikasjonskriterier

Alder som er kvalifisert for studier

Tar imot friske frivillige

Kjønn som er kvalifisert for studier

Beskrivelse

Studieplan

Hvordan er studiet utformet?

Designdetaljer

Antall våpen

Våpen og intervensjoner

Deltakergruppe / Arm

Intervensjon / Behandling

Hva måler studien?

Primære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Tiltaksbeskrivelse

Tidsramme

Samarbeidspartnere og etterforskere

Sponsor

Samarbeidspartnere

Etterforskere

Publikasjoner og nyttige lenker

Generelle publikasjoner

Studierekorddatoer

Studer hoveddatoer

Studiestart (FAKTISKE)

Primær fullføring (FAKTISKE)

Studiet fullført (FAKTISKE)

Datoer for studieregistrering

Først innsendt

Først innsendt som oppfylte QC-kriteriene

Først lagt ut (ANSLAG)

Oppdateringer av studieposter

Sist oppdatering lagt ut (FAKTISKE)

Siste oppdatering sendt inn som oppfylte QC-kriteriene

Sist bekreftet

Mer informasjon

Begreper knyttet til denne studien

Nøkkelord

Ytterligere relevante MeSH-vilkår

Andre studie-ID-numre

Plan for individuelle deltakerdata (IPD)

Planlegger du å dele individuelle deltakerdata (IPD)?

IPD-planbeskrivelse

Studiedata/dokumenter

Kliniske studier på Smerte

Kliniske studier på placebo

Søk i lignende forsøk

Sponsorer og samarbeidspartnere

Medisinsk tilstand

Legemiddelintervensjoner

CROs by country

CROs in Gambia

Forhold

Sjeldne sykdommer

Legemiddelintervensjoner

Kosttilskudd

Sponsor / samarbeidspartnere

Steder