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S1216, fase III ADT+TAK-700 vs. ADT+Bicalutamid til metastatisk prostatakræft (S1216)

10. december 2025 opdateret af: SWOG Cancer Research Network

Et fase III randomiseret forsøg, der sammenligner androgen deprivationsterapi + TAK-700 med androgen deprivationsterapi + Bicalutamid hos patienter med nyligt diagnosticeret metastatisk følsom prostatakræft

Formålet med denne undersøgelse er at sammenligne den overordnede overlevelse hos nyligt diagnosticerede metastaserende prostatacancerpatienter, der er randomiseret til androgen deprivationsterapi (ADT) + TAK-700 versus ADT + bicalutamid.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

1313

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • Veterans Administration Medical Center - Birmingham
    • Arizona
      • Phoenix, Arizona, Forenede Stater, 85004
        • University of Arizona Cancer Center at Saint Joseph's
      • Tucson, Arizona, Forenede Stater, 85704
        • University of Arizona Cancer Center-Orange Grove Campus
      • Tucson, Arizona, Forenede Stater, 85719
        • University of Arizona Cancer Center-North Campus
      • Tucson, Arizona, Forenede Stater, 85724
        • The University of Arizona Medical Center-University Campus
      • Tucson, Arizona, Forenede Stater, 85723
        • Southern Arizona Veterans Affairs Health Center
    • Arkansas
      • Jonesboro, Arkansas, Forenede Stater, 72401
        • Fowler Family Center for Cancer Care
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Veteran's Administration Medical Center
    • California
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Auburn, California, Forenede Stater, 95602
        • Sutter Auburn Faith Hospital
      • Bakersfield, California, Forenede Stater, 93301
        • AIS Cancer Center at San Joaquin Community Hospital
      • Berkeley, California, Forenede Stater, 94704
        • Alta Bates Summit Medical Center-Herrick Campus
      • Burlingame, California, Forenede Stater, 94010
        • Mills - Peninsula Hospitals
      • Corona, California, Forenede Stater, 92879
        • City of Hope Corona
      • Davis, California, Forenede Stater, 95616
        • Sutter Davis Hospital
      • Duarte, California, Forenede Stater, 91010
        • City of Hope Comprehensive Cancer Center
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente
      • Fresno, California, Forenede Stater, 93701
        • University Oncology Associates
      • La Jolla, California, Forenede Stater, 92093
        • UC San Diego Moores Cancer Center
      • Loma Linda, California, Forenede Stater, 92354
        • Loma Linda University Medical Center
      • Loma Linda, California, Forenede Stater, 92357
        • Veterans Affairs Loma Linda Healthcare System
      • Los Angeles, California, Forenede Stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90033
        • Los Angeles County-USC Medical Center
      • Marysville, California, Forenede Stater, 95901
        • Fremont - Rideout Cancer Center
      • Mather, California, Forenede Stater, 95655
        • Mather Veteran Affairs Medical Center
      • Merced, California, Forenede Stater, 95340
        • Mercy UC Davis Cancer Center
      • Modesto, California, Forenede Stater, 95355
        • Memorial Medical Center
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente-Modesto
      • Mountain View, California, Forenede Stater, 94040
        • Palo Alto Medical Foundation-Camino Division
      • Mountain View, California, Forenede Stater, 94040
        • Palo Alto Medical Foundation-Gynecologic Oncology
      • Newport Beach, California, Forenede Stater, 92663
        • USC Norris Oncology/Hematology-Newport Beach
      • Novato, California, Forenede Stater, 94945
        • Sutter Cancer Research Consortium
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Palo Alto, California, Forenede Stater, 94301
        • Palo Alto Medical Foundation Health Care
      • Pasadena, California, Forenede Stater, 91105
        • Keck Medical Center of USC Pasadena
      • Pismo Beach, California, Forenede Stater, 93449
        • PCR Oncology
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Roseville, California, Forenede Stater, 95661
        • Sutter Roseville Medical Center
      • Sacramento, California, Forenede Stater, 95817
        • University of California Davis Comprehensive Cancer Center
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95825
        • Kaiser Permanente - Sacramento
      • Sacramento, California, Forenede Stater, 95816
        • Sutter General Hospital
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Francisco, California, Forenede Stater, 94158
        • UCSF Medical Center-Mission Bay
      • San Francisco, California, Forenede Stater, 94115
        • California Pacific Medical Center-Pacific Campus
      • San Francisco, California, Forenede Stater, 94115
        • UCSF Medical Center-Mount Zion
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser Permanente-San Rafael
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Cruz, California, Forenede Stater, 95065
        • Palo Alto Medical Foundation-Santa Cruz
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • Santa Rosa, California, Forenede Stater, 95403
        • Sutter Pacific Medical Foundation
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Sunnyvale, California, Forenede Stater, 94086
        • Palo Alto Medical Foundation-Sunnyvale
      • Truckee, California, Forenede Stater, 96161
        • Gene Upshaw Memorial Tahoe Forest Cancer Center
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vacaville, California, Forenede Stater, 95687
        • Northbay Cancer Center
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Vallejo, California, Forenede Stater, 94589
        • Sutter Solano Medical Center/Cancer Center
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • University of Colorado Cancer Center - Anschutz Cancer Pavilion
      • Aurora, Colorado, Forenede Stater, 80012
        • Rocky Mountain Cancer Centers-Aurora
      • Aurora, Colorado, Forenede Stater, 80012
        • The Medical Center of Aurora
      • Boulder, Colorado, Forenede Stater, 80301
        • Boulder Community Hospital
      • Boulder, Colorado, Forenede Stater, 80304
        • Rocky Mountain Cancer Centers-Boulder
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forenede Stater, 80210
        • Porter Adventist Hospital
      • Denver, Colorado, Forenede Stater, 80218
        • Presbyterian - Saint Lukes Medical Center - Health One
      • Denver, Colorado, Forenede Stater, 80218
        • SCL Health Saint Joseph Hospital
      • Denver, Colorado, Forenede Stater, 80220
        • Rose Medical Center
      • Denver, Colorado, Forenede Stater, 80218
        • Rocky Mountain Cancer Centers-Midtown
      • Denver, Colorado, Forenede Stater, 80220
        • Rocky Mountain Cancer Centers-Rose
      • Denver, Colorado, Forenede Stater, 80218
        • Colorado Blood Cancer Institute
      • Denver, Colorado, Forenede Stater, 80222
        • Colorado Cancer Research Program NCORP
      • Durango, Colorado, Forenede Stater, 81301
        • Mercy Medical Center
      • Durango, Colorado, Forenede Stater, 81301
        • Southwest Oncology PC
      • Englewood, Colorado, Forenede Stater, 80113
        • Swedish Medical Center
      • Englewood, Colorado, Forenede Stater, 80113
        • Comprehensive Cancer Care and Research Institute of Colorado LLC
      • Golden, Colorado, Forenede Stater, 80401
        • Mountain Blue Cancer Care Center
      • Greeley, Colorado, Forenede Stater, 80631
        • North Colorado Medical Center
      • Greenwood Village, Colorado, Forenede Stater, 80111
        • Rocky Mountain Cancer Centers-Greenwood Village
      • Lakewood, Colorado, Forenede Stater, 80228
        • Saint Anthony Hospital
      • Lakewood, Colorado, Forenede Stater, 80228
        • Rocky Mountain Cancer Centers-Lakewood
      • Littleton, Colorado, Forenede Stater, 80120
        • Rocky Mountain Cancer Centers-Littleton
      • Littleton, Colorado, Forenede Stater, 80122
        • Littleton Adventist Hospital
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Sky Ridge Medical Center
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rocky Mountain Cancer Centers-Sky Ridge
      • Longmont, Colorado, Forenede Stater, 80501
        • Longmont United Hospital
      • Longmont, Colorado, Forenede Stater, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Loveland, Colorado, Forenede Stater, 80539
        • McKee Medical Center
      • Parker, Colorado, Forenede Stater, 80138
        • Parker Adventist Hospital
      • Parker, Colorado, Forenede Stater, 80138
        • Rocky Mountain Cancer Centers-Parker
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
      • Pueblo, Colorado, Forenede Stater, 81008
        • Rocky Mountain Cancer Centers - Pueblo
      • Thornton, Colorado, Forenede Stater, 80260
        • Rocky Mountain Cancer Centers-Thornton
      • Wheat Ridge, Colorado, Forenede Stater, 80033
        • SCL Health Lutheran Medical Center
    • Connecticut
      • Greenwich, Connecticut, Forenede Stater, 06830
        • Greenwich Hospital
      • New Haven, Connecticut, Forenede Stater, 06520
        • Yale University
      • Norwich, Connecticut, Forenede Stater, 06360
        • Eastern Connecticut Hematology and Oncology Associates
      • Stamford, Connecticut, Forenede Stater, 06904
        • Stamford Hospital/Bennett Cancer Center
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Beebe Medical Center
      • Newark, Delaware, Forenede Stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Newark, Delaware, Forenede Stater, 19713
        • Regional Hematology and Oncology PA
      • Seaford, Delaware, Forenede Stater, 19973
        • Nanticoke Memorial Hospital
    • District of Columbia
      • Washington D.C., District of Columbia, Forenede Stater, 20037
        • George Washington University Medical Center
      • Washington D.C., District of Columbia, Forenede Stater, 20010
        • Medstar Washington Hospital Center
      • Washington D.C., District of Columbia, Forenede Stater, 20007
        • MedStar Georgetown University Hospital
      • Washington D.C., District of Columbia, Forenede Stater, 20016
        • Sibley Memorial Hospital
      • Washington D.C., District of Columbia, Forenede Stater, 20422
        • Veterans Affairs Medical Center -Washington DC
    • Florida
      • Fort Lauderdale, Florida, Forenede Stater, 33316
        • Broward Health Medical Center
      • Lakeland, Florida, Forenede Stater, 33805
        • Lakeland Regional Health Hollis Cancer Center
      • Orlando, Florida, Forenede Stater, 32803
        • Florida Hospital Orlando
      • Orlando, Florida, Forenede Stater, 32806
        • UF Cancer Center at Orlando Health
      • Tampa, Florida, Forenede Stater, 33612
        • Moffitt Cancer Center
    • Georgia
      • Columbus, Georgia, Forenede Stater, 31904
        • John B Amos Cancer Center
      • Decatur, Georgia, Forenede Stater, 30033
        • Atlanta VA Medical Center
      • Gainesville, Georgia, Forenede Stater, 30501
        • Northeast Georgia Medical Center-Gainesville
      • Savannah, Georgia, Forenede Stater, 31405
        • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Queen's Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • University of Hawaii Cancer Center
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Cancer Care Inc-Liliha
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente Moanalua Medical Center
      • Honolulu, Hawaii, Forenede Stater, 96813
        • Hawaii Cancer Care Inc-POB II
      • Honolulu, Hawaii, Forenede Stater, 96817
        • Hawaii Oncology Inc-Kuakini
      • Honolulu, Hawaii, Forenede Stater, 96859
        • Tripler Army Medical Center
      • ‘Aiea, Hawaii, Forenede Stater, 96701
        • Hawaii Oncology Inc-Pali Momi
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Medical Center
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Cancer Center
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Kootenai Cancer Clinic
    • Illinois
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush - Copley Medical Center
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare-Bloomington
      • Bloomington, Illinois, Forenede Stater, 61701
        • Saint Joseph Medical Center
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare-Canton
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60637
        • University of Chicago Comprehensive Cancer Center
      • Chicago, Illinois, Forenede Stater, 60608
        • Mount Sinai Hospital Medical Center
      • Chicago, Illinois, Forenede Stater, 60640
        • Weiss Memorial Hospital
      • Chicago, Illinois, Forenede Stater, 60657
        • Presence Saint Joseph Hospital-Chicago
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Heartland Cancer Research NCORP
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Center of Decatur
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare-Eureka
      • Evanston, Illinois, Forenede Stater, 60201
        • NorthShore University HealthSystem-Evanston Hospital
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Forenede Stater, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Glenview, Illinois, Forenede Stater, 60026
        • NorthShore University HealthSystem-Glenbrook Hospital
      • Highland Park, Illinois, Forenede Stater, 60035
        • NorthShore University HealthSystem-Highland Park Hospital
      • Hines, Illinois, Forenede Stater, 60141
        • Hines Veterans Administration Hospital
      • Joliet, Illinois, Forenede Stater, 60435
        • Joliet Oncology-Hematology Associates Limited
      • Kankakee, Illinois, Forenede Stater, 60901
        • Presence Saint Mary's Hospital
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare-Macomb
      • Maywood, Illinois, Forenede Stater, 60153
        • Loyola University Medical Center
      • Moline, Illinois, Forenede Stater, 61265
        • Trinity Medical Center
      • Monmouth, Illinois, Forenede Stater, 61462
        • Illinois CancerCare-Monmouth
      • Normal, Illinois, Forenede Stater, 61761
        • Community Cancer Center Foundation
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Ottawa, Illinois, Forenede Stater, 61350
        • Ottawa Regional Hospital and Healthcare Center
      • Pekin, Illinois, Forenede Stater, 61554
        • Illinois CancerCare-Pekin
      • Pekin, Illinois, Forenede Stater, 61554
        • OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
      • Peoria, Illinois, Forenede Stater, 61637
        • OSF Saint Francis Medical Center
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peoria, Illinois, Forenede Stater, 61614
        • Proctor Hospital
      • Peoria, Illinois, Forenede Stater, 61603
        • Methodist Medical Center of Illinois
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare-Peru
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare-Princeton
      • River Forest, Illinois, Forenede Stater, 60305
        • West Suburban Medical Center
      • Rockford, Illinois, Forenede Stater, 61114
        • SwedishAmerican Regional Cancer Center/ACT
      • Springfield, Illinois, Forenede Stater, 62781
        • Memorial Medical Center
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Swansea, Illinois, Forenede Stater, 62226
        • Cancer Care Specialists of Illinois-Swansea
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Yorkville, Illinois, Forenede Stater, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Bloomington, Indiana, Forenede Stater, 47403
        • IU Health Bloomington
      • Mishawaka, Indiana, Forenede Stater, 46545
        • Memorial Regional Cancer Center Day Road
      • South Bend, Indiana, Forenede Stater, 46601
        • Memorial Hospital of South Bend
      • Valparaiso, Indiana, Forenede Stater, 46383
        • Porter Memorial Hospital
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic PC-William R Bliss Cancer Center
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Mercy Hospital
      • Cedar Rapids, Iowa, Forenede Stater, 52403
        • Oncology Associates at Mercy Medical Center
      • Clive, Iowa, Forenede Stater, 50325
        • Medical Oncology and Hematology Associates-West Des Moines
      • Council Bluffs, Iowa, Forenede Stater, 51503
        • Alegent Health Mercy Hospital
      • Davenport, Iowa, Forenede Stater, 52803
        • Genesis Medical Center - East Campus
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50314
        • Medical Oncology and Hematology Associates-Laurel
      • Iowa City, Iowa, Forenede Stater, 52242
        • University of Iowa/Holden Comprehensive Cancer Center
      • Iowa City, Iowa, Forenede Stater, 52246
        • Iowa City VA Healthcare System
    • Kansas
      • Chanute, Kansas, Forenede Stater, 66720
        • Cancer Center of Kansas - Chanute
      • Dodge City, Kansas, Forenede Stater, 67801
        • Cancer Center of Kansas - Dodge City
      • El Dorado, Kansas, Forenede Stater, 67042
        • Cancer Center of Kansas - El Dorado
      • Fort Scott, Kansas, Forenede Stater, 66701
        • Cancer Center of Kansas - Fort Scott
      • Garden City, Kansas, Forenede Stater, 67846
        • Saint Catherine Hospital
      • Great Bend, Kansas, Forenede Stater, 67530
        • Saint Rose Ambulatory and Surgery Center
      • Great Bend, Kansas, Forenede Stater, 67530
        • Heartland Cancer Center
      • Hays, Kansas, Forenede Stater, 67601
        • Hays Medical Center
      • Independence, Kansas, Forenede Stater, 67301
        • Cancer Center of Kansas-Independence
      • Kansas City, Kansas, Forenede Stater, 66160
        • University of Kansas Cancer Center
      • Kansas City, Kansas, Forenede Stater, 66112
        • University of Kansas Cancer Center-West
      • Kingman, Kansas, Forenede Stater, 67068
        • Cancer Center of Kansas-Kingman
      • Lawrence, Kansas, Forenede Stater, 66044
        • Lawrence Memorial Hospital
      • Liberal, Kansas, Forenede Stater, 67905
        • Cancer Center of Kansas-Liberal
      • Manhattan, Kansas, Forenede Stater, 66502
        • Cancer Center of Kansas-Manhattan
      • McPherson, Kansas, Forenede Stater, 67460
        • Cancer Center of Kansas - McPherson
      • Newton, Kansas, Forenede Stater, 67114
        • Cancer Center of Kansas - Newton
      • Olathe, Kansas, Forenede Stater, 66061
        • Olathe Medical Center
      • Overland Park, Kansas, Forenede Stater, 66210
        • University of Kansas Cancer Center-Overland Park
      • Overland Park, Kansas, Forenede Stater, 66209
        • Menorah Medical Center
      • Parsons, Kansas, Forenede Stater, 67357
        • Cancer Center of Kansas - Parsons
      • Pratt, Kansas, Forenede Stater, 67124
        • Cancer Center of Kansas - Pratt
      • Salina, Kansas, Forenede Stater, 67401
        • Salina Regional Health Center
      • Salina, Kansas, Forenede Stater, 67401
        • Cancer Center of Kansas - Salina
      • Topeka, Kansas, Forenede Stater, 66606
        • Cotton O'Neil Cancer Center / Stormont Vail Health
      • Topeka, Kansas, Forenede Stater, 66606
        • Saint Francis Hospital and Medical Center - Topeka
      • Topeka, Kansas, Forenede Stater, 66622
        • Topeka VA Hospital
      • Wellington, Kansas, Forenede Stater, 67152
        • Cancer Center of Kansas - Wellington
      • Wichita, Kansas, Forenede Stater, 67208
        • Cancer Center of Kansas-Wichita Medical Arts Tower
      • Wichita, Kansas, Forenede Stater, 67214
        • Cancer Center of Kansas - Wichita
      • Wichita, Kansas, Forenede Stater, 67208
        • Associates In Womens Health
      • Wichita, Kansas, Forenede Stater, 67214
        • Wichita NCI Community Oncology Research Program
      • Wichita, Kansas, Forenede Stater, 67214
        • Via Christi Regional Medical Center
      • Winfield, Kansas, Forenede Stater, 67156
        • Cancer Center of Kansas - Winfield
    • Kentucky
      • Lexington, Kentucky, Forenede Stater, 40536
        • University of Kentucky/Markey Cancer Center
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Ochsner Health Center-Summa
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Hematology/Oncology Clinic LLP
      • Kenner, Louisiana, Forenede Stater, 70065
        • Ochsner Medical Center Kenner
      • Metairie, Louisiana, Forenede Stater, 70006
        • East Jefferson General Hospital
      • New Orleans, Louisiana, Forenede Stater, 70121
        • Ochsner Medical Center Jefferson
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Tulane University Health Sciences Center
      • New Orleans, Louisiana, Forenede Stater, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Louisiana State University Health Science Center
    • Maine
      • Augusta, Maine, Forenede Stater, 04330
        • Harold Alfond Center for Cancer Care
      • Bangor, Maine, Forenede Stater, 04401
        • Eastern Maine Medical Center
      • Rockport, Maine, Forenede Stater, 04856
        • Penobscot Bay Medical Center
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21287
        • Johns Hopkins University/Sidney Kimmel Cancer Center
      • Olney, Maryland, Forenede Stater, 20832
        • Montgomery General Hospital-Olney
    • Massachusetts
      • Boston, Massachusetts, Forenede Stater, 02215
        • Dana-Farber Cancer Institute
      • Boston, Massachusetts, Forenede Stater, 02118
        • Boston Medical Center
      • Brighton, Massachusetts, Forenede Stater, 02135
        • Steward Saint Elizabeth's Medical Center
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Lahey Hospital and Medical Center
      • Quincy, Massachusetts, Forenede Stater, 02169
        • Dana Farber Community Cancer Care-Quincy
    • Michigan
      • Adrian, Michigan, Forenede Stater, 49221
        • Hickman Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106-0995
        • Saint Joseph Mercy Hospital
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University of Michigan Comprehensive Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Michigan Cancer Research Consortium NCORP
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Brighton, Michigan, Forenede Stater, 48114
        • Saint Joseph Mercy Brighton
      • Brighton, Michigan, Forenede Stater, 48114
        • IHA Hematology Oncology Consultants-Brighton
      • Canton, Michigan, Forenede Stater, 48188
        • IHA Hematology Oncology Consultants-Canton
      • Canton, Michigan, Forenede Stater, 48188
        • Saint Joseph Mercy Canton Health Center
      • Chelsea, Michigan, Forenede Stater, 48118
        • Saint Joseph Mercy Chelsea
      • Chelsea, Michigan, Forenede Stater, 48118
        • IHA Hematology Oncology Consultants-Chelsea
      • Detroit, Michigan, Forenede Stater, 48236
        • Saint John Hospital and Medical Center
      • Escanaba, Michigan, Forenede Stater, 49829
        • Green Bay Oncology - Escanaba
      • Farmington, Michigan, Forenede Stater, 48334
        • Botsford General Hospital
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Spectrum Health at Butterworth Campus
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Mercy Health Saint Mary's
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Cancer Research Consortium of West Michigan NCORP
      • Iron Mountain, Michigan, Forenede Stater, 49801
        • Green Bay Oncology - Iron Mountain
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Lansing, Michigan, Forenede Stater, 48912
        • Sparrow Hospital
      • Muskegon, Michigan, Forenede Stater, 49444
        • Mercy Health Mercy Campus
      • Niles, Michigan, Forenede Stater, 49120
        • Lakeland Community Hospital
      • Pontiac, Michigan, Forenede Stater, 48341
        • Saint Joseph Mercy Oakland
      • Port Huron, Michigan, Forenede Stater, 48060
        • Lake Huron Medical Center
      • Reed City, Michigan, Forenede Stater, 49677
        • Spectrum Health Reed City Hospital
      • Royal Oak, Michigan, Forenede Stater, 48073
        • William Beaumont Hospital-Royal Oak
      • Saginaw, Michigan, Forenede Stater, 48601
        • Saint Mary's of Michigan
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Marie Yeager Cancer Center
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Troy, Michigan, Forenede Stater, 48098
        • William Beaumont Hospital - Troy
      • Warren, Michigan, Forenede Stater, 48093
        • Saint John Macomb-Oakland Hospital
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • IHA Hematology Oncology Consultants-Ann Arbor
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Clinic North-Bemidgi
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Duluth, Minnesota, Forenede Stater, 55805
        • Essentia Health Cancer Center
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview-Southdale Hospital
      • Fergus Falls, Minnesota, Forenede Stater, 56537
        • Lake Region Healthcare Corporation-Cancer Care
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Health Partners Inc
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • University of Minnesota/Masonic Cancer Center
      • Minneapolis, Minnesota, Forenede Stater, 55417
        • Minneapolis Veterans Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Rochester, Minnesota, Forenede Stater, 55905
        • Mayo Clinic
      • Saint Cloud, Minnesota, Forenede Stater, 56303
        • Coborn Cancer Center at Saint Cloud Hospital
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Metro Minnesota Community Oncology Research Consortium
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
    • Mississippi
      • Jackson, Mississippi, Forenede Stater, 39216
        • University of Mississippi Medical Center
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Southeast Cancer Center
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Siteman Cancer Center - Saint Peters
      • Columbia, Missouri, Forenede Stater, 65212
        • University of Missouri - Ellis Fischel
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Barnes-Jewish West County Hospital
      • Joplin, Missouri, Forenede Stater, 64804
        • Mercy Hospital-Joplin
      • Kansas City, Missouri, Forenede Stater, 64128
        • Kansas City Veterans Affairs Medical Center
      • Kansas City, Missouri, Forenede Stater, 64131
        • The University of Kansas Cancer Center-South
      • Kansas City, Missouri, Forenede Stater, 64111
        • Saint Luke's Hospital of Kansas City
      • Kansas City, Missouri, Forenede Stater, 64132
        • Research Medical Center
      • Kansas City, Missouri, Forenede Stater, 64108
        • Truman Medical Center
      • Kansas City, Missouri, Forenede Stater, 64154
        • The University of Kansas Cancer Center-North
      • Lee's Summit, Missouri, Forenede Stater, 64064
        • The University of Kansas Cancer Center-Lee's Summit
      • Rolla, Missouri, Forenede Stater, 65401
        • Delbert Day Cancer Institute at PCRMC
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Forenede Stater, 63109
        • Saint Louis Cancer and Breast Institute-South City
    • Montana
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Billings, Montana, Forenede Stater, 59101
        • Saint Vincent Healthcare
      • Billings, Montana, Forenede Stater, 59102
        • Montana Cancer Consortium NCORP
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Deaconess Hospital
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Healthcare- Sletten Cancer Institute
    • Nebraska
      • Grand Island, Nebraska, Forenede Stater, 68803
        • CHI Health Saint Francis
      • Kearney, Nebraska, Forenede Stater, 68847
        • CHI Health Good Samaritan
      • Omaha, Nebraska, Forenede Stater, 68114
        • Nebraska Methodist Hospital
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Forenede Stater, 68131
        • Creighton University Medical Center
    • Nevada
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Nevada Cancer Research Foundation CCOP
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology Hematology PA-Concord
      • Hooksett, New Hampshire, Forenede Stater, 03106
        • New Hampshire Oncology Hematology PA-Hooksett
      • Laconia, New Hampshire, Forenede Stater, 03246
        • LRGHealthcare-Lakes Region General Hospital
    • New Jersey
      • East Orange, New Jersey, Forenede Stater, 07018-1095
        • Veterans Adminstration New Jersey Health Care System
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Rutgers Cancer Institute of New Jersey
      • Sparta, New Jersey, Forenede Stater, 07871
        • Sparta Cancer Treatment Center
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • University of New Mexico Cancer Center
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • Lovelace Medical Center-Downtown
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Hematology Oncology Associates
      • Las Cruces, New Mexico, Forenede Stater, 88011
        • Memorial Medical Center - Las Cruces
      • Santa Fe, New Mexico, Forenede Stater, 87505
        • Christus Saint Vincent Regional Cancer Center
    • New York
      • Brooklyn, New York, Forenede Stater, 11209
        • Veteran Affairs New York Harbor Healthcare System-Brooklyn Campus
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Buffalo, New York, Forenede Stater, 14215
        • Veterans Affairs Western New York Health Care System-Buffalo
      • East Syracuse, New York, Forenede Stater, 13057
        • Hematology Oncology Associates of Central New York-East Syracuse
      • Elmira, New York, Forenede Stater, 14905
        • Arnot Ogden Medical Center/Falck Cancer Center
      • Glens Falls, New York, Forenede Stater, 12801
        • Glens Falls Hospital
      • Middletown, New York, Forenede Stater, 10940
        • Orange Regional Medical Center
      • New York, New York, Forenede Stater, 10065
        • Weill Medical College of Cornell University
      • New York, New York, Forenede Stater, 10016
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
      • New York, New York, Forenede Stater, 10032
        • Columbia University/Herbert Irving Cancer Center
      • Rochester, New York, Forenede Stater, 14642
        • University of Rochester
      • Syracuse, New York, Forenede Stater, 13210
        • State University of New York Upstate Medical University
      • The Bronx, New York, Forenede Stater, 10467-2490
        • Montefiore Medical Center - Moses Campus
      • The Bronx, New York, Forenede Stater, 10461
        • Montefiore Medical Center-Weiler Hospital
      • White Plains, New York, Forenede Stater, 10601
        • Dickstein Cancer Treatment Center
    • North Carolina
      • Asheville, North Carolina, Forenede Stater, 28801
        • Mission Hospital-Memorial Campus
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Concord, North Carolina, Forenede Stater, 28025
        • Carolinas HealthCare System NorthEast
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Hendersonville Hematology and Oncology at Pardee
      • Hendersonville, North Carolina, Forenede Stater, 28791
        • Margaret R Pardee Memorial Hospital
      • Hendersonville, North Carolina, Forenede Stater, 28792
        • Park Ridge Hospital Breast Health Center
      • Kinston, North Carolina, Forenede Stater, 28501
        • Kinston Medical Specialists PA
      • Monroe, North Carolina, Forenede Stater, 28112
        • Carolinas HealthCare System Union
      • Shelby, North Carolina, Forenede Stater, 28150
        • Carolinas HealthCare System Cleveland
      • Statesville, North Carolina, Forenede Stater, 28677
        • Iredell Memorial Hospital
      • Winston-Salem, North Carolina, Forenede Stater, 27104
        • Southeast Clinical Oncology Research (SCOR) Consortium NCORP
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Clinic North-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Medical Center-Fargo
      • Fargo, North Dakota, Forenede Stater, 58122
        • Roger Maris Cancer Center
    • Ohio
      • Akron, Ohio, Forenede Stater, 44304
        • Summa Akron City Hospital/Cooper Cancer Center
      • Barberton, Ohio, Forenede Stater, 44203
        • Summa Barberton Hospital
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45219
        • The Christ Hospital
      • Cincinnati, Ohio, Forenede Stater, 45219
        • University of Cincinnati/Barrett Cancer Center
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Medical Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Columbus, Ohio, Forenede Stater, 43215
        • Columbus NCI Community Oncology Research Program
      • Dayton, Ohio, Forenede Stater, 45406
        • Good Samaritan Hospital - Dayton
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Samaritan North Health Center
      • Dayton, Ohio, Forenede Stater, 45420
        • Dayton NCI Community Oncology Research Program
      • Dayton, Ohio, Forenede Stater, 45428
        • Veteran Affairs Medical Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Findlay, Ohio, Forenede Stater, 45840
        • Armes Family Cancer Center
      • Findlay, Ohio, Forenede Stater, 45840
        • Orion Cancer Care
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Franklin, Ohio, Forenede Stater, 45005
        • Dayton Physicians LLC-Atrium
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Lima, Ohio, Forenede Stater, 45801
        • Saint Rita's Medical Center
      • Marietta, Ohio, Forenede Stater, 45750
        • Marietta Memorial Hospital
      • Maumee, Ohio, Forenede Stater, 43537
        • Toledo Clinic Cancer Centers-Maumee
      • Oregon, Ohio, Forenede Stater, 43616
        • Saint Charles Hospital
      • Perrysburg, Ohio, Forenede Stater, 43551
        • Mercy Health Perrysburg Cancer Center
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Southern Ohio Medical Center
      • Springfield, Ohio, Forenede Stater, 45505
        • Springfield Regional Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Toledo Clinic Cancer Centers-Toledo
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Saint Anne Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Westerville, Ohio, Forenede Stater, 43081
        • Saint Ann's Hospital
      • Wpafb, Ohio, Forenede Stater, 45433-5529
        • Wright-Patterson Medical Center
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Oklahoma Cancer Specialists and Research Institute-Tulsa
    • Oregon
      • Gresham, Oregon, Forenede Stater, 97030
        • Legacy Mount Hood Medical Center
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health and Science University
      • Portland, Oregon, Forenede Stater, 97210
        • Legacy Good Samaritan Hospital and Medical Center
      • Portland, Oregon, Forenede Stater, 97227
        • Kaiser Permanente Northwest
      • Portland, Oregon, Forenede Stater, 97239
        • Portland Veterans Administration Medical Center
      • Tualatin, Oregon, Forenede Stater, 97062
        • Legacy Meridian Park Hospital
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Doylestown, Pennsylvania, Forenede Stater, 18901
        • Doylestown Hospital
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Penn State Milton S Hershey Medical Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19111
        • Fox Chase Cancer Center
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Thomas Jefferson University Hospital
      • Philadelphia, Pennsylvania, Forenede Stater, 19140
        • Temple University Hospital
      • Scranton, Pennsylvania, Forenede Stater, 18508
        • Hematology and Oncology Associates of North East Pennsylvania
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Reading Hospital
    • South Carolina
      • Anderson, South Carolina, Forenede Stater, 29621
        • AnMed Health Cancer Center
      • Charleston, South Carolina, Forenede Stater, 29425
        • Medical University of South Carolina
      • Charleston, South Carolina, Forenede Stater, 29401
        • Roper Hospital
      • Charleston, South Carolina, Forenede Stater, 29403
        • Charleston Hematology Oncology Associates-Roper
      • Charleston, South Carolina, Forenede Stater, 29414
        • Charleston Hematology Oncology Associates PA-St. Francis
      • Easley, South Carolina, Forenede Stater, 29640
        • Greenville Health System Cancer Institute-Easley
      • Greenville, South Carolina, Forenede Stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Faris
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Memorial Hospital
      • Greenville, South Carolina, Forenede Stater, 29615
        • Greenville Health System Cancer Institute-Eastside
      • Greenville, South Carolina, Forenede Stater, 29605
        • Greenville Health System Cancer Institute-Butternut
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Self Regional Healthcare
      • Greer, South Carolina, Forenede Stater, 29650
        • Greenville Health System Cancer Institute-Greer
      • Seneca, South Carolina, Forenede Stater, 29672
        • Greenville Health System Cancer Institute-Seneca
      • Spartanburg, South Carolina, Forenede Stater, 29303
        • Spartanburg Medical Center
      • Spartanburg, South Carolina, Forenede Stater, 29307
        • Greenville Health System Cancer Institute-Spartanburg
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center-Oncology Clinic
    • Tennessee
      • Knoxville, Tennessee, Forenede Stater, 37920
        • University of Tennessee - Knoxville
      • Nashville, Tennessee, Forenede Stater, 37208
        • Meharry Medical College
    • Texas
      • Houston, Texas, Forenede Stater, 77030
        • M D Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77026-1967
        • Lyndon Baines Johnson General Hospital
      • Houston, Texas, Forenede Stater, 77030
        • Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
      • Houston, Texas, Forenede Stater, 77030
        • Michael E DeBakey VA Medical Center
      • Houston, Texas, Forenede Stater, 77094
        • MD Anderson Regional Care Center-Katy
      • Houston, Texas, Forenede Stater, 77030
        • Ben Taub General Hospital
      • Nassau Bay, Texas, Forenede Stater, 77058
        • MD Anderson Regional Care Center-Bay Area
      • Sugar Land, Texas, Forenede Stater, 77478
        • MD Anderson Regional Care Center-Sugar Land
      • The Woodlands, Texas, Forenede Stater, 77384
        • MD Anderson Regional Care Center-The Woodlands
    • Utah
      • Salt Lake City, Utah, Forenede Stater, 84112
        • Huntsman Cancer Institute/University of Utah
    • Virginia
      • Falls Church, Virginia, Forenede Stater, 22042
        • Inova Fairfax Hospital
      • Lynchburg, Virginia, Forenede Stater, 24501
        • Lynchburg Hematology-Oncology Clinic
      • Martinsville, Virginia, Forenede Stater, 24115
        • Memorial Hospital Of Martinsville
      • Richmond, Virginia, Forenede Stater, 23298
        • Virginia Commonwealth University/Massey Cancer Center
      • South Hill, Virginia, Forenede Stater, 23970
        • VCU Community Memorial Health Center
      • Winchester, Virginia, Forenede Stater, 22601
        • Shenandoah Oncology Associates PC
    • Washington
      • Auburn, Washington, Forenede Stater, 98001
        • MultiCare Auburn Medical Center
      • Bellingham, Washington, Forenede Stater, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Burien, Washington, Forenede Stater, 98166
        • Highline Medical Center-Main Campus
      • Everett, Washington, Forenede Stater, 98201
        • Providence Regional Cancer Partnership
      • Gig Harbor, Washington, Forenede Stater, 98335
        • MultiCare Gig Harbor Medical Park
      • Kennewick, Washington, Forenede Stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Kirkland, Washington, Forenede Stater, 98034
        • Seattle Cancer Care Alliance at EvergreenHealth
      • Mount Vernon, Washington, Forenede Stater, 98274
        • Skagit Valley Hospital
      • Port Townsend, Washington, Forenede Stater, 98368
        • Jefferson Healthcare
      • Puyallup, Washington, Forenede Stater, 98372
        • MultiCare Good Samaritan Hospital
      • Seattle, Washington, Forenede Stater, 98109
        • Fred Hutchinson Cancer Research Center
      • Seattle, Washington, Forenede Stater, 98195
        • University of Washington Medical Center
      • Seattle, Washington, Forenede Stater, 98104
        • Minor and James Medical PLLC
      • Seattle, Washington, Forenede Stater, 98112
        • Group Health Cooperative-Seattle
      • Seattle, Washington, Forenede Stater, 98122-4307
        • Swedish Medical Center-First Hill
      • Spokane, Washington, Forenede Stater, 99204
        • Rockwood Cancer Treatment Center-DHEC-Downtown
      • Spokane, Washington, Forenede Stater, 99220
        • Rockwood Clinic
      • Spokane Valley, Washington, Forenede Stater, 99216
        • Rockwood Clinic Cancer Treatment Center-Valley
      • Tacoma, Washington, Forenede Stater, 98431
        • Madigan Army Medical Center
      • Tacoma, Washington, Forenede Stater, 98405
        • MultiCare Tacoma General Hospital
      • Tacoma, Washington, Forenede Stater, 98405
        • Northwest NCI Community Oncology Research Program
      • Vancouver, Washington, Forenede Stater, 98686
        • Legacy Salmon Creek Hospital
      • Walla Walla, Washington, Forenede Stater, 99362
        • Providence Saint Mary Regional Cancer Center
    • West Virginia
      • Charleston, West Virginia, Forenede Stater, 25304
        • West Virginia University Charleston
      • Huntington, West Virginia, Forenede Stater, 25701
        • Edwards Comprehensive Cancer Center
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Langlade Hospital and Cancer Center
      • Burlington, Wisconsin, Forenede Stater, 53105
        • Aurora Cancer Care-Southern Lakes VLCC
      • Chippewa Falls, Wisconsin, Forenede Stater, 54729
        • Marshfield Clinic-Chippewa Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Clinic Cancer Center at Sacred Heart
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Sacred Heart Hospital
      • Fond du Lac, Wisconsin, Forenede Stater, 54937
        • Aurora Health Center-Fond du Lac
      • Germantown, Wisconsin, Forenede Stater, 53022
        • Aurora Health Care Germantown Health Center
      • Grafton, Wisconsin, Forenede Stater, 53024
        • Aurora Cancer Care-Grafton
      • Green Bay, Wisconsin, Forenede Stater, 54311
        • Aurora BayCare Medical Center
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Saint Vincent Hospital Cancer Center Green Bay
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Saint Vincent Hospital Cancer Center at Saint Mary's
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Green Bay Oncology Limited at Saint Mary's Hospital
      • Green Bay, Wisconsin, Forenede Stater, 54301-3526
        • Green Bay Oncology at Saint Vincent Hospital
      • Johnson Creek, Wisconsin, Forenede Stater, 53038
        • UW Cancer Center Johnson Creek
      • Kenosha, Wisconsin, Forenede Stater, 53142
        • Aurora Cancer Care-Kenosha South
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Ladysmith, Wisconsin, Forenede Stater, 54848
        • Marshfield Clinic - Ladysmith Center
      • Madison, Wisconsin, Forenede Stater, 53792
        • University of Wisconsin Hospital and Clinics
      • Manitowoc, Wisconsin, Forenede Stater, 54221
        • Holy Family Memorial Hospital
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Aurora Bay Area Medical Group-Marinette
      • Marinette, Wisconsin, Forenede Stater, 54143
        • Vince Lombardi Cancer Clinic-Marinette
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Clinic
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Saint Joseph's Hospital
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Froedtert and the Medical College of Wisconsin
      • Milwaukee, Wisconsin, Forenede Stater, 53209
        • Aurora Cancer Care-Milwaukee
      • Milwaukee, Wisconsin, Forenede Stater, 53215
        • Aurora Saint Luke's Medical Center
      • Milwaukee, Wisconsin, Forenede Stater, 53233
        • Aurora Sinai Medical Center
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Clinic-Minocqua Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconto Falls, Wisconsin, Forenede Stater, 54154
        • Green Bay Oncology - Oconto Falls
      • Oshkosh, Wisconsin, Forenede Stater, 54904
        • Vince Lombardi Cancer Clinic - Oshkosh
      • Racine, Wisconsin, Forenede Stater, 53406
        • Aurora Cancer Care-Racine
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Saint Mary's Hospital
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Marshfield Clinic at James Beck Cancer Center
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Clinic-Rice Lake Center
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Vince Lombardi Cancer Clinic-Sheboygan
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • HSHS Saint Nicholas Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Clinic Stevens Point Center
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Saint Michael's Hospital
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Marshfield Clinic Cancer Care at Saint Michael's Hospital
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235
        • Green Bay Oncology - Sturgeon Bay
      • Summit, Wisconsin, Forenede Stater, 53066
        • Aurora Medical Center in Summit
      • Two Rivers, Wisconsin, Forenede Stater, 54241
        • Vince Lombardi Cancer Clinic-Two Rivers
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Aurora Cancer Care-Waukesha
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Aspirus Regional Cancer Center
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Marshfield Clinic-Wausau Center
      • Wauwatosa, Wisconsin, Forenede Stater, 53226
        • Aurora Cancer Care-Milwaukee West
      • West Allis, Wisconsin, Forenede Stater, 53227
        • Aurora West Allis Medical Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Diagnostic and Treatment Center
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Clinic - Weston Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Marshfield Clinic - Wisconsin Rapids Center
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Aspirus UW Cancer Center
    • Wyoming
      • Cody, Wyoming, Forenede Stater, 82414
        • Billings Clinic-Cody

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Klinisk diagnose af metastatisk prostatacancer.
  • Serum testosteron inden for institutionelle grænser for normale.
  • PSA ≥ 2 ng/ml inden for 90 dage før påbegyndelse af androgen-deprivation. terapi (til tidlig induktion) eller før registrering (til sen induktion).
  • DEXA-scanning inden for 2 år før registrering.
  • EKG inden for 42 dage før registrering og QTc-interval ≤ 460 msek.
  • LVEF inden for 42 dage før registrering og inden for institutionelle grænser.
  • Tilstrækkelig leverfunktion som påvist af bilirubin ≤ 2 x institutionel øvre normalgrænse (ULN), SGOT (AST) og SGPT (ALT) ≤ 3 x institutionel ULN eller ≤ 5 x institutionel ULN, hvis levermetastaser er til stede.
  • Tilstrækkelig nyrefunktion som påvist ved beregnet kreatininclearance ≥ 40 ml/min.
  • Tilstrækkelig hæmatologisk funktion som påvist af leukocytter ≥ 3.000/mcL, absolut neutrofiltal (ANC) ≥ 1.500/mcL, hæmoglobin ≥ 9 g/dL og blodplader ≥ 100.000/mcL.
  • Zubrod præstationsstatus på 0 - 2. Zubrod præstationsstatus 3 vil være tilladt, hvis det kun skyldes knoglesmerter.
  • ≥ 18 år.
  • Mænd med reproduktionspotentiale og dem, der er kirurgisk steriliseret (dvs. postvasektomi) skal acceptere at praktisere effektiv barriereprævention eller acceptere at afholde sig fra samleje, mens de modtager behandling i denne undersøgelse og i mindst 4 måneder efter protokolbehandlingen slutter.

Ekskluderingskriterier:

  • Kendte hjernemetastaser.
  • Ikke mere end 36 måneders tidligere neoadjuverende og/eller adjuverende hormonbehandling.
  • ≥ 6 måneder siden afsluttet behandling med androgendeprivation.
  • Forudgående eller samtidig behandling med ketoconazol, aminoglutethimid eller abirateronacetat eller enzalutamid (MDV3100). Samtidig megestrol til hedeture er tilladt.
  • Forudgående kemoterapi til behandling af metastatisk prostatacancer. Forudgående kemoterapi i neoadjuverende eller adjuverende omgivelser er tilladt.
  • ≥ 2 år efter afslutning af kemoterapi i neoadjuverende eller adjuverende omgivelser.
  • Samtidig brug af eksperimentel terapi er ikke tilladt.
  • ≥ 30 dage siden tidligere medicinsk kastration for metastatisk prostatacancer.
  • Hvis kastrationsmetoden er en LHRH-agonist, skal patienten være villig til at fortsætte brugen af ​​LHRH og tilføje bicalutamid eller TAK-700 under protokolbehandling.
  • Hvis patienten var på et antiandrogen (f.eks. bicalutamid, flutamid), skal patienten være villig til at skifte til bicalutamid eller TAK-700 (ifølge randomisering).
  • Forudgående bilateral orkiektomi.
  • Samtidig brug af LHRH-antagonister (f.eks. Degarelix)
  • Grad III/IV hjertesygdom (som defineret af NYHA-kriterierne), tromboembolisk hændelse, ustabil angina pectoris, myokardieinfarkt inden for 6 måneder eller alvorlig ukontrolleret hjertearytmi.
  • Ukontrolleret hypertension (defineret som blodtryk > 160 mmHg systolisk og > 90 mmHg diastolisk ved 2 separate målinger med ikke mere end 60 minutters mellemrum under screeningsbesøget) på trods af passende medicinsk behandling.
  • Kendt human immundefektvirus (HIV)-infektion, aktiv kronisk hepatitis B eller C, livstruende sygdom, der ikke er relateret til cancer, eller enhver alvorlig medicinsk eller psykiatrisk sygdom, der efter efterforskerens mening potentielt kunne forstyrre deltagelse i denne undersøgelse.
  • Anamnese med primær og sekundær binyrebarkinsufficiens.
  • Overfølsomhed over for TAK-700, over for TAK-700-metabolitter, over for bicalutamid eller over for LHRH-agonister.
  • Gastrointestinal (GI) sygdom eller GI-procedure, der kan interferere med GI-absorptionen eller tolerancen af ​​TAK-700, herunder besvær med at sluge oral medicin.
  • Ingen anden tidligere malignitet er tilladt med undtagelse af følgende: tilstrækkeligt behandlet basalcelle- eller pladecellehudkræft, tilstrækkeligt behandlet kræft i fase I eller II, hvorfra patienten i øjeblikket er i fuldstændig remission, eller enhver anden kræftsygdom, som patienten har været sygdom af- gratis i 5 år.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Eksperimentel: ADT + TAK-700

LHRH-agonist - givet som godkendt til androgendeprivation i en dosis, der er nødvendig for at opretholde kastratniveauer og svarende til 22,5 mg Leuprolide IM hver 3. måned.

TAK-700, 300 mg, PO, to gange dagligt
Medicin: TAK-700
300 mg, PO, to gange dagligt
Andre navne:
  • Orteronel
Aktiv komparator: ADT + Bicalutamid

LHRH-agonist - givet som godkendt til androgendeprivation i en dosis, der er nødvendig for at opretholde kastratniveauer og svarende til 22,5 mg Leuprolide IM hver 3. måned.

Bicalutamid, 50 mg, PO, q dagligt
Medicin: Bicalutamid
50 mg, PO, q dagligt
Andre navne:
  • Casodex

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Samlet overlevelse
Tidsramme: Behandlingsvarighed og opfølgning indtil døden eller 9 år efter studiestart
Den samlede overlevelse defineres som tiden fra tilfældig tildeling til dødsdatoen af ​​enhver årsag
Behandlingsvarighed og opfølgning indtil døden eller 9 år efter studiestart

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
PSA svarprocenter
Tidsramme: 7 måneder efter randomisering
Prostata-specifikt antigen (PSA) responsrater blev opdelt i fuldstændig respons (CR: PSA < 0,2 ng/ml), delvis respons (PR: PSA mellem 0,2 og 4,0 ng/ml) og ingen respons (NR: PSA > 4,0 ng /ml) ved et 7-måneders vartegn efter tilfældig tildeling.
7 måneder efter randomisering
Langsigtet overlevelse
Tidsramme: Efter 10 års opfølgning
Langtidsoverlevelse er defineret som tiden fra tilfældig tildeling til datoen for dødsfald uanset årsag
Efter 10 års opfølgning
Progression gratis overlevelse
Tidsramme: Behandlingsvarighed og opfølgning indtil døden eller 9 år efter studiestart

Progression Free Survival (PFS) er defineret som tidspunktet fra tilfældig tildeling til første dokumentation af PSA -progression, radiologisk progression, klinisk progression eller død, alt efter hvad der skete først.

PSA -progression defineres som en ≥25% stigning og og absolut stigning på sidst 2 ng/ml fra Nadir PSA (eller fra baseline PSA, hvis der ikke var noget fald i PSA efter start af behandlingen).

Radiologisk progression defineres som to eller flere nye læsioner på radionuklid -knoglescanninger.

Klinisk progression defineres ved hjælp af responsevalueringskriterierne i faste tumorer (RECIST v1.0), som en stigning på 20% i summen af ​​den længste diameter af mållæsioner eller en målbar stigning i en ikke-mållæsion eller udseendet af nye læsioner.
Behandlingsvarighed og opfølgning indtil døden eller 9 år efter studiestart
Antal deltagere med GR 3 til 5 bivirkninger, der er relateret til undersøgelsesmedicin
Tidsramme: Behandlingsvarighed og opfølgning indtil døden eller 9 år efter studiestart

Kun bivirkninger, der muligvis er, sandsynligvis eller bestemt relateret til undersøgelsesmedicin, rapporteres. Bivirkninger klassificeres ved hjælp af de fælles terminologikriterier for bivirkninger (CTCAE v4.0) Hvor klasse henviser til sværhedsgraden af ​​AE.

Grad 3: Alvorlig eller medicinsk markant, men ikke umiddelbart livstruende; hospitalisering eller forlængelse af hospitalisering indikeret; deaktivering; Begrænsende selvpleje.

Grad 4: Livstruende konsekvenser; Hastende indgreb indikeret. Grad 5: Døden relateret til Ae.
Behandlingsvarighed og opfølgning indtil døden eller 9 år efter studiestart

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

SWOG Cancer Research Network

Samarbejdspartnere

National Cancer Institute (NCI)
Millennium Pharmaceuticals, Inc.

Efterforskere

  • Ledende efterforsker: Neeraj Agarwal, M.D., University of Utah

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Hjælpsomme links

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

8. marts 2013

Primær færdiggørelse (Faktiske)

8. marts 2022

Studieafslutning (Faktiske)

9. september 2025

Datoer for studieregistrering

Først indsendt

8. marts 2013

Først indsendt, der opfyldte QC-kriterier

8. marts 2013

Først opslået (Anslået)

13. marts 2013

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Anslået)

31. december 2025

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

10. december 2025

Sidst verificeret

1. december 2025

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • S1216
  • SWOG-S1216 (Andet bevillings-/finansieringsnummer: U10CA180888)
  • NCI-2012-02876 (Anden identifikator: NCI)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

https://swog.org/Visitors/Download/Policies/Policy43.pdf

Studiedata/dokumenter

  1. Individuelt deltagerdatasæt
    Oplysningskommentarer: Vælg individuelle data på patientniveau fra dette forsøg kan rekvireres fra NCTN/NCORP Data Archive

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med TAK-700

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Sponsorer og samarbejdspartnere

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Betingelser

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Sponsor / samarbejdspartnere

Placeringer

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