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Kombinationskemoterapi med eller uden atezolizumab til behandling af patienter med trin III tyktarmskræft og mangelfuld DNA mismatch reparation

3. april 2024 opdateret af: National Cancer Institute (NCI)

Randomiseret forsøg med standard kemoterapi alene eller kombineret med atezolizumab som adjuverende terapi til patienter med trin III tyktarmskræft og mangelfuld DNA mismatch reparation

Dette fase III-forsøg undersøger kombinationskemoterapi og atezolizumab for at se, hvor godt det virker sammenlignet med kombinationskemoterapi alene til behandling af patienter med stadium III tyktarmskræft og mangelfuld deoxyribonukleinsyre (DNA) mismatch reparation. Lægemidler, der bruges i kombinationskemoterapi, såsom oxaliplatin, leucovorin calcium og fluorouracil, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. Immunterapi med monoklonale antistoffer, såsom atezolizumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig. At give kombinationskemoterapi med atezolizumab kan virke bedre end kombinationskemoterapi alene til behandling af patienter med tyktarmskræft.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. At afgøre, om atezolizumab kombineret med fluorouracil (FOLFOX) og dets fortsættelse som monoterapi signifikant kan forbedre sygdomsfri overlevelse (DFS) sammenlignet med FOLFOX alene hos patienter med stadium III coloncancer og mangelfuld DNA-mismatch-reparation (dMMR).

SEKUNDÆRE MÅL:

I. At bestemme om atezolizumab kombineret med FOLFOX og dets fortsættelse som monoterapi kan forbedre den samlede overlevelse signifikant sammenlignet med FOLFOX alene hos patienter med stadium III coloncancer og dMMR.

II. For at vurdere bivirkningsprofilen (AE) og sikkerheden for hver behandlingsarm ved at bruge Common Terminology Criteria for Adverse Events (CTCAE) og patientrelaterede udfald (PRO)-CTCAE (blandt patienter i alderen >= 18 år).

LIVSKVALITET MÅL:

I. At bestemme virkningen af tilføjelsen af atezolizumab til FOLFOX på patientrapporteret neuropati, sundhedsrelateret livskvalitet (QOL) og funktionelle domæner af sundhedsrelateret livskvalitet.

II. For at få adgang til effekten af atezolizumab justering for baseline QOL og træthedsmålinger.

POTENTIELLE KORRLATIVE VIDENSKABELIGE MÅL:

I. For at bestemme, om "immunoscore" kan forudsige effektiviteten af atezolizumab til sygdomsfri overlevelse blandt patienter med stadium III tyktarmskræft.

II. At vurdere, om cirkulerende immuncellepopulationer kan forudsige effektiviteten af atezolizumab som adjuverende behandling for stadium III tyktarmskræft.

III. At udforske associationerne af genomiske ændringer identificeret i cellefrit (cf)DNA med DFS hos patienter behandlet med FOLFOX med eller uden atezolizumab.

IV. At vurdere, om opløselige markører for systemisk inflammation i blod kan forudsige effektiviteten af atezolizumab som adjuverende behandling for stadium III tyktarmskræft.

V. For at vurdere sammenhængen mellem baseline plasma 25(OH) D-niveauer, ændring i 25(OH)D-niveauer og DFS og overordnet overlevelse (OS) hos patienter med stadium III coloncancer, der modtager FOLFOX +/- atezolizumab.

VI. For at bestemme evnen til at bruge fækal mikrobiota og deres metaboliske produkter til at forudsige overlevelsesfordele ved anti-PD-L1 antistofterapi hos dMMR-tyktarmskræftpatienter.

VII. For at bestemme, om hypermutation eller hyper-indel-status er forbundet med respons på atezolizumab.

VIII. For at bestemme, om unikke messenger ribonukleinsyre (mRNA) ekspressionssignaturer er forudsigelige for sygdomsfri overlevelse blandt patienter, der modtager adjuverende kemoterapi for stadium III tyktarmskræft.

IX. For at bestemme, om effektiviteten af atezolizumab adskiller sig blandt dMMR-kræftformer på grund af germline MMR-mutation (MLH1, MSH2, MSH6, PMS2) sammenlignet med dem med MLH1-hypermethylering og CIMP hos patienter med stadium III coloncancer.

X. At identificere overordnet mutationsbyrde og antallet af formodede tumor neoantigener i tyktarmskarcinomprøver.

XI. For at bestemme ændringer i vækstmønstre sammenlignet med baseline (i forhold til aldersspecifikke standarder for højde og vægt). (Patienter i alderen 12 til < 18 år for at vurdere virkningen af atezolizumab på vækst- og udviklingsmønstre i denne population) XII. For at bestemme ændringer i udviklingsmønstre sammenlignet med baseline (i forhold til indtræden af menarche [for kvinder] og pubertetsforandringer). (Patienter i alderen 12 til < 18 år for at evaluere virkningen af atezolizumab på vækst- og udviklingsmønstre i denne population)

OVERSIGT: Patienterne randomiseres til 1 ud af 2 arme.

ARM I: Patienter får oxaliplatin intravenøst (IV) over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV som en bolus på dag 1, derefter kontinuerligt over 46 timer på dag 1-3. Behandlingen gentages hver 14. dag i op til 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter får også atezolizumab IV over 30-60 minutter, startende på dag 1 i cyklus 1 eller 2. Behandlingen gentages hver 14. dag i op til 25 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter gennemgår computertomografi (CT) eller magnetisk resonansbilleddannelse (MRI) hver 6. måned i de første 2 år, derefter i 3-5 år eller indtil tegn på tilbagefald, alt efter hvad der kommer først. Patienter kan også gennemgå blodprøvetagning under hele forsøget.

ARM II: Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV som bolus på dag 1, derefter kontinuerligt over 46 timer på dag 1-3. Behandlingen gentages hver 14. dag i op til 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter gennemgår CT eller MR hver 6. måned i de første 2 år, derefter i 3-5 år eller indtil tegn på tilbagefald, alt efter hvad der kommer først. Patienter kan også gennemgå blodprøvetagning under hele forsøget.

Efter afsluttet undersøgelsesbehandling følges patienterne op for recidiv hver 6. måned i 2 år, derefter årligt i 3 år. Patienterne følges også op for overlevelse hver 6. måned i op til 8 år.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

700

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Phoenix, Arizona, Forenede Stater, 85054
    - Mayo Clinic Hospital in Arizona
  - Phoenix, Arizona, Forenede Stater, 85004
    - Cancer Center at Saint Joseph's
  - Scottsdale, Arizona, Forenede Stater, 85259
    - Mayo Clinic in Arizona
  - Tucson, Arizona, Forenede Stater, 85719
    - Banner University Medical Center - Tucson
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center-North Campus
- Arkansas
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
- California
  - Anaheim, California, Forenede Stater, 92806
    - Kaiser Permanente-Anaheim
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Clovis, California, Forenede Stater, 93611
    - Community Cancer Institute
  - Clovis, California, Forenede Stater, 93611
    - University Oncology Associates
  - Concord, California, Forenede Stater, 94520
    - John Muir Medical Center-Concord Campus
  - Costa Mesa, California, Forenede Stater, 92627
    - UC Irvine Health Cancer Center-Newport
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Dublin, California, Forenede Stater, 94568
    - Epic Care-Dublin
  - Emeryville, California, Forenede Stater, 94608
    - Epic Care Partners in Cancer Care
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente - Harbor City
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente West Los Angeles
  - Los Angeles, California, Forenede Stater, 90020
    - Keck Medicine of USC Koreatown
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles General Medical Center
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach, California, Forenede Stater, 92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Ontario, California, Forenede Stater, 91761
    - Kaiser Permanente-Ontario
  - Orange, California, Forenede Stater, 92868
    - UC Irvine Health/Chao Family Comprehensive Cancer Center
  - Palo Alto, California, Forenede Stater, 94304
    - VA Palo Alto Health Care System
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forenede Stater, 92123
    - Sharp Memorial Hospital
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Marcos, California, Forenede Stater, 92078
    - Kaiser Permanente-San Marcos
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Vacaville, California, Forenede Stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - West Covina, California, Forenede Stater, 91790
    - City of Hope West Covina
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80920
    - Memorial Hospital North
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80206
    - National Jewish Health-Main Campus
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - Southwest Oncology PC
  - Englewood, Colorado, Forenede Stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Cancer Care and Hematology-Fort Collins
  - Golden, Colorado, Forenede Stater, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Grand Junction, Colorado, Forenede Stater, 81505
    - Grand Valley Oncology
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - UCHealth Greeley Hospital
  - Highlands Ranch, Colorado, Forenede Stater, 80129
    - UCHealth Highlands Ranch Hospital
  - Lafayette, Colorado, Forenede Stater, 80026
    - Good Samaritan Medical Center
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Loveland, Colorado, Forenede Stater, 80538
    - Medical Center of the Rockies
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forenede Stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forenede Stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forenede Stater, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Derby, Connecticut, Forenede Stater, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, Forenede Stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Glastonbury, Connecticut, Forenede Stater, 06033
    - Smilow Cancer Hospital Care Center at Glastonbury
  - Greenwich, Connecticut, Forenede Stater, 06830
    - Smilow Cancer Hospital Care Center at Greenwich
  - Guilford, Connecticut, Forenede Stater, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Middletown, Connecticut, Forenede Stater, 06457
    - Middlesex Hospital
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - North Haven, Connecticut, Forenede Stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Torrington, Connecticut, Forenede Stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull, Connecticut, Forenede Stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, Forenede Stater, 06385
    - Smilow Cancer Hospital Care Center - Waterford
- Delaware
  - Dover, Delaware, Forenede Stater, 19901
    - Bayhealth Hospital Kent Campus
  - Frankford, Delaware, Forenede Stater, 19945
    - Beebe South Coastal Health Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Milford, Delaware, Forenede Stater, 19963
    - Bayhealth Hospital Sussex Campus
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20010
    - MedStar Washington Hospital Center
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Aventura, Florida, Forenede Stater, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Celebration, Florida, Forenede Stater, 34747
    - AdventHealth Celebration
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Halifax Health Medical Center-Centers for Oncology
  - Fort Lauderdale, Florida, Forenede Stater, 33316
    - Broward Health Medical Center
  - Fort Myers, Florida, Forenede Stater, 33905
    - Regional Cancer Center-Lee Memorial Health System
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Augusta, Georgia, Forenede Stater, 30901
    - Augusta Oncology Associates PC-D'Antignac
  - Augusta, Georgia, Forenede Stater, 30909
    - Augusta Oncology Associates PC-Wheeler
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Queen's Cancer Center - Pearlridge
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - The Cancer Center of Hawaii-Pali Momi
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Cancer Care - Westridge
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Island Urology
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Cancer Institute - Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Cancer Clinic
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Barrington, Illinois, Forenede Stater, 60010
    - Advocate Good Shepherd Hospital
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forenede Stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Crystal Lake, Illinois, Forenede Stater, 60014
    - AMG Crystal Lake - Oncology
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - DeKalb, Illinois, Forenede Stater, 60115
    - Northwestern Medicine Cancer Center Kishwaukee
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forenede Stater, 61021
    - Illinois CancerCare-Dixon
  - Downers Grove, Illinois, Forenede Stater, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Elgin, Illinois, Forenede Stater, 60123
    - Advocate Sherman Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - Saint Francis Hospital
  - Freeport, Illinois, Forenede Stater, 61032
    - Freeport Memorial Hospital/Leonard C Ferguson Cancer Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Hazel Crest, Illinois, Forenede Stater, 60429
    - Advocate South Suburban Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Forenede Stater, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - Condell Memorial Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - New Lenox, Illinois, Forenede Stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Orland Park, Illinois, Forenede Stater, 60462
    - University of Chicago Medicine-Orland Park
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Silvis, Illinois, Forenede Stater, 61282
    - Genesis Cancer Center - Silvis
  - Skokie, Illinois, Forenede Stater, 60076
    - Hematology Oncology Associates of Illinois - Skokie
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Swansea, Illinois, Forenede Stater, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington, Illinois, Forenede Stater, 61571
    - Illinois CancerCare - Washington
- Indiana
  - Carmel, Indiana, Forenede Stater, 46032
    - IU Health North Hospital
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mooresville, Indiana, Forenede Stater, 46158
    - Franciscan Health Mooresville
  - New Albany, Indiana, Forenede Stater, 47150
    - Baptist Health Floyd
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - Terre Haute, Indiana, Forenede Stater, 47804
    - Union Hospital
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic - Ames
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic - Boone
  - Carroll, Iowa, Forenede Stater, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Cancer Care Institute
  - Davenport, Iowa, Forenede Stater, 52807
    - Iowa Cancer Specialists
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mission Cancer and Blood - Laurel
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - Trinity Regional Medical Center
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Iowa City, Iowa, Forenede Stater, 52242
    - University of Iowa/Holden Comprehensive Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic - Marshalltown
  - Mason City, Iowa, Forenede Stater, 50401
    - Mercy Medical Center - North Iowa
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Coffeyville, Kansas, Forenede Stater, 67337
    - Coffeyville Regional Medical Center
  - Garden City, Kansas, Forenede Stater, 67846
    - Central Care Cancer Center - Garden City
  - Garden City, Kansas, Forenede Stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forenede Stater, 67530
    - Central Care Cancer Center - Great Bend
  - Hays, Kansas, Forenede Stater, 67601
    - HaysMed University of Kansas Health System
  - Kansas City, Kansas, Forenede Stater, 66112
    - University of Kansas Cancer Center-West
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Lenexa, Kansas, Forenede Stater, 66219
    - Kansas Institute of Medicine Cancer and Blood Center
  - Lenexa, Kansas, Forenede Stater, 66219
    - Minimally Invasive Surgery Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Health Cancer Center
  - Overland Park, Kansas, Forenede Stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Overland Park, Kansas, Forenede Stater, 66209
    - Menorah Medical Center
  - Overland Park, Kansas, Forenede Stater, 66213
    - Saint Luke's South Hospital
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Ascension Via Christi - Pittsburg
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Topeka, Kansas, Forenede Stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Westwood, Kansas, Forenede Stater, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
- Kentucky
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Edgewood, Kentucky, Forenede Stater, 41017
    - Saint Elizabeth Healthcare Edgewood
  - Fort Thomas, Kentucky, Forenede Stater, 41075
    - Saint Elizabeth Fort Thomas
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - London, Kentucky, Forenede Stater, 40741
    - Saint Joseph London
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Our Lady of the Lake Physicians Group - Medical Oncology
  - Baton Rouge, Louisiana, Forenede Stater, 70816
    - Medical Center of Baton Rouge
  - Baton Rouge, Louisiana, Forenede Stater, 70836
    - Ochsner High Grove
  - Baton Rouge, Louisiana, Forenede Stater, 70808
    - Our Lady of The Lake
  - Covington, Louisiana, Forenede Stater, 70433
    - Northshore Oncology Associates-Covington
  - Covington, Louisiana, Forenede Stater, 70433
    - Ochsner Hematology Oncology North Shore - Covington (West Region)
  - Houma, Louisiana, Forenede Stater, 70360
    - Oncology Center of The South Incorporated
  - Kenner, Louisiana, Forenede Stater, 70065
    - Ochsner Medical Center Kenner
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - Shreveport, Louisiana, Forenede Stater, 71105
    - CHRISTUS Highland Medical Center
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Belfast, Maine, Forenede Stater, 04915
    - Waldo County General Hospital
  - Biddeford, Maine, Forenede Stater, 04005
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Rockport, Maine, Forenede Stater, 04856
    - Penobscot Bay Medical Center
  - Sanford, Maine, Forenede Stater, 04073
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
  - South Portland, Maine, Forenede Stater, 04106
    - Maine Medical Partners - South Portland
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Glen Burnie, Maryland, Forenede Stater, 21061
    - UM Baltimore Washington Medical Center/Tate Cancer Center
  - Ocean Pines, Maryland, Forenede Stater, 21811
    - TidalHealth Richard A Henson Cancer Institute
  - Salisbury, Maryland, Forenede Stater, 21801
    - TidalHealth Peninsula Regional
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Saint Joseph Mercy Hospital
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Bay City, Michigan, Forenede Stater, 48706
    - McLaren Cancer Institute-Bay City
  - Bloomfield, Michigan, Forenede Stater, 48302
    - McLaren Cancer Institute-Bloomfield
  - Brighton, Michigan, Forenede Stater, 48114
    - Saint Joseph Mercy Brighton
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Brownstown, Michigan, Forenede Stater, 48183
    - Henry Ford Cancer Institute-Downriver
  - Canton, Michigan, Forenede Stater, 48188
    - Saint Joseph Mercy Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Caro, Michigan, Forenede Stater, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Forenede Stater, 48118
    - Saint Joseph Mercy Chelsea
  - Chelsea, Michigan, Forenede Stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Clarkston, Michigan, Forenede Stater, 48346
    - McLaren Cancer Institute-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Newland Medical Associates-Clarkston
  - Clinton Township, Michigan, Forenede Stater, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Forenede Stater, 48124
    - Beaumont Hospital - Dearborn
  - Dearborn, Michigan, Forenede Stater, 48126
    - Henry Ford Medical Center-Fairlane
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - East China Township, Michigan, Forenede Stater, 48054
    - Great Lakes Cancer Management Specialists-Doctors Park
  - East Lansing, Michigan, Forenede Stater, 48824
    - Michigan State University Clinical Center
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Farmington Hills, Michigan, Forenede Stater, 48336
    - Beaumont Hospital - Farmington Hills
  - Flint, Michigan, Forenede Stater, 48532
    - Singh and Arora Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Cancer and Blood Disease Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grosse Pointe, Michigan, Forenede Stater, 48230
    - William Beaumont Hospital-Grosse Pointe
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Academic Hematology Oncology Specialists
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Michigan Breast Specialists-Grosse Pointe Woods
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - Ascension Borgess Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Mid-Michigan Physicians-Lansing
  - Lansing, Michigan, Forenede Stater, 48910
    - Karmanos Cancer Institute at McLaren Greater Lansing
  - Lansing, Michigan, Forenede Stater, 48912
    - University of Michigan Health - Sparrow Lansing
  - Lapeer, Michigan, Forenede Stater, 48446
    - McLaren Cancer Institute-Lapeer Region
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forenede Stater, 48044
    - Great Lakes Cancer Management Specialists-Macomb Medical Campus
  - Macomb, Michigan, Forenede Stater, 48044
    - Michigan Breast Specialists-Macomb Township
  - Marlette, Michigan, Forenede Stater, 48453
    - Saint Mary's Oncology/Hematology Associates of Marlette
  - Monroe, Michigan, Forenede Stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Mount Clemens, Michigan, Forenede Stater, 48043
    - McLaren Cancer Institute-Macomb
  - Mount Pleasant, Michigan, Forenede Stater, 48858
    - McLaren Cancer Institute-Central Michigan
  - Novi, Michigan, Forenede Stater, 48374
    - Ascension Providence Hospitals - Novi
  - Novi, Michigan, Forenede Stater, 48377
    - Henry Ford Medical Center-Columbus
  - Petoskey, Michigan, Forenede Stater, 49770
    - McLaren Cancer Institute-Northern Michigan
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Pontiac, Michigan, Forenede Stater, 48341
    - 21st Century Oncology-Pontiac
  - Pontiac, Michigan, Forenede Stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Newland Medical Associates-Pontiac
  - Port Huron, Michigan, Forenede Stater, 48060
    - McLaren-Port Huron
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forenede Stater, 49677
    - Corewell Health Reed City Hospital
  - Rochester Hills, Michigan, Forenede Stater, 48309
    - Great Lakes Cancer Management Specialists-Rochester Hills
  - Roseville, Michigan, Forenede Stater, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Hematology Oncology Consultants PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Oakland Medical Group
  - Royal Oak, Michigan, Forenede Stater, 48067
    - Oakland Colon Rectal Associates
  - Saginaw, Michigan, Forenede Stater, 48601
    - Ascension Saint Mary's Hospital
  - Saginaw, Michigan, Forenede Stater, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saginaw, Michigan, Forenede Stater, 48604
    - Covenant HealthCare Mackinaw
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Southfield, Michigan, Forenede Stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Premier Hematology Oncology Care
  - Sterling Heights, Michigan, Forenede Stater, 48314
    - Mitchell Folbe MD PC
  - Tawas City, Michigan, Forenede Stater, 48764
    - Ascension Saint Joseph Hospital
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forenede Stater, 48085
    - William Beaumont Hospital - Troy
  - Troy, Michigan, Forenede Stater, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Forenede Stater, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Forenede Stater, 48098
    - Hematology Oncology Consultants PC-Troy
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Warren, Michigan, Forenede Stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forenede Stater, 48093
    - Great Lakes Cancer Management Specialists-Macomb Professional Building
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Michigan Breast Specialists-Warren
  - West Bloomfield, Michigan, Forenede Stater, 48322
    - Henry Ford West Bloomfield Hospital
  - West Branch, Michigan, Forenede Stater, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Minnesota Oncology - Burnsville
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Deer River, Minnesota, Forenede Stater, 56636
    - Essentia Health - Deer River Clinic
  - Duluth, Minnesota, Forenede Stater, 55805
    - Saint Luke's Hospital of Duluth
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hibbing, Minnesota, Forenede Stater, 55746
    - Essentia Health Hibbing Clinic
  - Mankato, Minnesota, Forenede Stater, 56001
    - Mayo Clinic Health Systems-Mankato
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Minneapolis, Minnesota, Forenede Stater, 55417
    - Minneapolis VA Medical Center
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Sandstone, Minnesota, Forenede Stater, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Virginia, Minnesota, Forenede Stater, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Grenada, Mississippi, Forenede Stater, 38901
    - Baptist Cancer Center-Grenada
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - New Albany, Mississippi, Forenede Stater, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Forenede Stater, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Saint Louis Cancer and Breast Institute-Ballwin
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center - Bolivar
  - Bonne Terre, Missouri, Forenede Stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forenede Stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Columbia, Missouri, Forenede Stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Independence, Missouri, Forenede Stater, 64057
    - Centerpoint Medical Center LLC
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Southwest Campus
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Kansas City, Missouri, Forenede Stater, 64154
    - University of Kansas Cancer Center - North
  - Kansas City, Missouri, Forenede Stater, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64132
    - Research Medical Center
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Centers
  - Lee's Summit, Missouri, Forenede Stater, 64064
    - University of Kansas Cancer Center - Lee's Summit
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - Saint Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - Saint Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - BJC Outpatient Center at Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forenede Stater, 68845
    - Heartland Hematology and Oncology
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68118
    - Nebraska Medicine-Village Pointe
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Hematology and Oncology Consultants PC
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - OptumCare Cancer Care at Seven Hills
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - GenesisCare USA - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89109
    - GenesisCare USA - Las Vegas
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89148
    - OptumCare Cancer Care at Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - GenesisCare USA - Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89148
    - GenesisCare USA - Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Pahrump, Nevada, Forenede Stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Exeter, New Hampshire, Forenede Stater, 03833
    - Exeter Hospital
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center-Manchester
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Solinsky Center for Cancer Care
  - Nashua, New Hampshire, Forenede Stater, 03063
    - Dartmouth Cancer Center - Nashua
- New Jersey
  - Basking Ridge, New Jersey, Forenede Stater, 07920
    - Memorial Sloan Kettering Basking Ridge
  - Cape May Court House, New Jersey, Forenede Stater, 08210
    - AtlantiCare Health Park-Cape May Court House
  - Egg Harbor Township, New Jersey, Forenede Stater, 08234
    - AtlantiCare Surgery Center
  - Englewood, New Jersey, Forenede Stater, 07631
    - Englewood Hospital and Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Livingston, New Jersey, Forenede Stater, 07039
    - Saint Barnabas Medical Center
  - Middletown, New Jersey, Forenede Stater, 07748
    - Memorial Sloan Kettering Monmouth
  - Montvale, New Jersey, Forenede Stater, 07645
    - Memorial Sloan Kettering Bergen
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, Forenede Stater, 08062
    - Inspira Medical Center Mullica Hill
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Paramus, New Jersey, Forenede Stater, 07652
    - The Valley Hospital-Luckow Pavilion
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Hospital
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Neurosurgeons of New Jersey-Ridgewood
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Vineland, New Jersey, Forenede Stater, 08360
    - Inspira Medical Center Vineland
  - Westwood, New Jersey, Forenede Stater, 07675
    - Valley Health System-Hematology/Oncology
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center-Saint Joseph Square
  - Albuquerque, New Mexico, Forenede Stater, 87110
    - Presbyterian Kaseman Hospital
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
  - Rio Rancho, New Mexico, Forenede Stater, 87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Auburn, New York, Forenede Stater, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Brooklyn, New York, Forenede Stater, 11219
    - Maimonides Medical Center
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Commack, New York, Forenede Stater, 11725
    - Memorial Sloan Kettering Commack
  - Cooperstown, New York, Forenede Stater, 13326
    - Mary Imogene Bassett Hospital
  - East Hills, New York, Forenede Stater, 11548
    - Cancer Institute at Saint Francis Hospital
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Elmira, New York, Forenede Stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Harrison, New York, Forenede Stater, 10604
    - Memorial Sloan Kettering Westchester
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forenede Stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Vassar Brothers Medical Center
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Rochester, New York, Forenede Stater, 14621
    - Rochester General Hospital
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13215
    - Hematology Oncology Associates of Central New York-Onondaga Hill
  - Uniondale, New York, Forenede Stater, 11553
    - Memorial Sloan Kettering Nassau
  - West Islip, New York, Forenede Stater, 11795
    - Good Samaritan University Hospital
  - White Plains, New York, Forenede Stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Albemarle, North Carolina, Forenede Stater, 28002
    - Atrium Health Stanly/LCI-Albemarle
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28803
    - AdventHealth Infusion Center Asheville
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28210
    - Atrium Health Pineville/LCI-Pineville
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Atrium Health University City/LCI-University
  - Charlotte, North Carolina, Forenede Stater, 28211
    - Levine Cancer Institute-SouthPark
  - Charlotte, North Carolina, Forenede Stater, 28277
    - Levine Cancer Institute-Ballantyne
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clyde, North Carolina, Forenede Stater, 28721
    - AdventHealth Infusion Center Haywood
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Gastonia, North Carolina, Forenede Stater, 28054
    - Levine Cancer Institute-Gaston
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Greensboro, North Carolina, Forenede Stater, 27410
    - Cone Health Cancer Center at Drawbridge Parkway
  - Greenville, North Carolina, Forenede Stater, 27834
    - East Carolina University
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - AdventHealth Hendersonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Onslow Memorial Hospital
  - Kenansville, North Carolina, Forenede Stater, 28349
    - Vidant Oncology-Kenansville
  - Kinston, North Carolina, Forenede Stater, 28501
    - Vidant Oncology-Kinston
  - Lincolnton, North Carolina, Forenede Stater, 28092
    - Atrium Health Lincoln/LCI-Lincolnton
  - Mebane, North Carolina, Forenede Stater, 27302
    - Cone Heath Cancer Center at Mebane
  - Monroe, North Carolina, Forenede Stater, 28112
    - Atrium Health Union/LCI-Union
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Richlands, North Carolina, Forenede Stater, 28574
    - Vidant Oncology-Richlands
  - Shelby, North Carolina, Forenede Stater, 28150
    - Atrium Health Cleveland/LCI-Cleveland
  - Washington, North Carolina, Forenede Stater, 27889
    - Marion L Shepard Cancer Center at Vidant Beaufort Hospital
  - Weaverville, North Carolina, Forenede Stater, 28787
    - AdventHealth Infusion Center Weaverville
  - Wilmington, North Carolina, Forenede Stater, 28401
    - Novant Health New Hanover Regional Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Grand Forks, North Dakota, Forenede Stater, 58201
    - Altru Cancer Center
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Beavercreek, Ohio, Forenede Stater, 45431
    - Indu and Raj Soin Medical Center
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Forenede Stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physician LLC-Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Kettering, Ohio, Forenede Stater, 45420
    - First Dayton Cancer Care
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Mansfield, Ohio, Forenede Stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forenede Stater, 43302
    - OhioHealth Marion General Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Radiation Oncology at Northwest Ohio Onocolgy Center
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Perrysburg, Ohio, Forenede Stater, 43551
    - Mercy Health Perrysburg Cancer Center
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Steubenville, Ohio, Forenede Stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Strongsville, Ohio, Forenede Stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC - Troy
  - Warrensville Heights, Ohio, Forenede Stater, 44122
    - South Pointe Hospital
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
    - Wright-Patterson Medical Center
  - Youngstown, Ohio, Forenede Stater, 44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Medical Center-Baker City
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Corvallis, Oregon, Forenede Stater, 97330
    - Good Samaritan Hospital
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Medical Center-Ontario
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
- Pennsylvania
  - Abington, Pennsylvania, Forenede Stater, 19001
    - Jefferson Abington Hospital
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Allentown, Pennsylvania, Forenede Stater, 18104
    - Saint Luke's Cancer Center - Allentown
  - Altoona, Pennsylvania, Forenede Stater, 16601
    - UPMC Altoona
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bethlehem, Pennsylvania, Forenede Stater, 18015
    - Saint Luke's University Hospital-Bethlehem Campus
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forenede Stater, 16001
    - UPMC Hillman Cancer Center at Butler Health System
  - Camp Hill, Pennsylvania, Forenede Stater, 17011
    - UPMC Camp Hill
  - Carlisle, Pennsylvania, Forenede Stater, 17015
    - Carlisle Regional Cancer Center
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - WellSpan Medical Oncology and Hematology
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - East Norriton, Pennsylvania, Forenede Stater, 19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - Easton, Pennsylvania, Forenede Stater, 18045
    - Saint Luke's Hospital-Anderson Campus
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Community Hospital
  - Erie, Pennsylvania, Forenede Stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Farrell, Pennsylvania, Forenede Stater, 16121
    - UPMC Cancer Center at UPMC Horizon
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Greenville, Pennsylvania, Forenede Stater, 16125
    - Oncology Hematology Associates
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - Cherry Tree Cancer Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Indiana, Pennsylvania, Forenede Stater, 15701
    - IRMC Cancer Center
  - Jefferson Hills, Pennsylvania, Forenede Stater, 15025
    - Jefferson Hospital
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Mechanicsburg, Pennsylvania, Forenede Stater, 17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - Forbes Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - UPMC Hillman Cancer Center - Monroeville
  - Moon, Pennsylvania, Forenede Stater, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Mount Pleasant, Pennsylvania, Forenede Stater, 15666
    - UPMC Hillman Cancer Center - Part of Frick Hospital
  - N. Huntingdon, Pennsylvania, Forenede Stater, 15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - Allegheny Valley Hospital
  - New Castle, Pennsylvania, Forenede Stater, 16105
    - UPMC Hillman Cancer Center - New Castle
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - Children's Hospital of Philadelphia
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15219
    - UPMC-Mercy Hospital
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Cancer Services-Pottsville
  - Quakertown, Pennsylvania, Forenede Stater, 18951
    - Saint Luke's Hospital-Quakertown Campus
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Selinsgrove, Pennsylvania, Forenede Stater, 17870
    - Geisinger Medical Oncology-Selinsgrove
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Cancer Center-Uniontown
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Cancer Center-Washington
  - West Mifflin, Pennsylvania, Forenede Stater, 15122
    - UPMC West Mifflin-Cancer Center Jefferson
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17754
    - Divine Providence Hospital
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
  - York, Pennsylvania, Forenede Stater, 17403
    - Cancer Care Associates of York
  - York, Pennsylvania, Forenede Stater, 17408
    - UPMC Memorial
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02903
    - Rhode Island Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Boiling Springs, South Carolina, Forenede Stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Clinton, South Carolina, Forenede Stater, 29325
    - Prisma Health Cancer Institute - Laurens
  - Easley, South Carolina, Forenede Stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Gaffney, South Carolina, Forenede Stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Greenville Memorial Hospital
  - Greenwood, South Carolina, Forenede Stater, 29646
    - Self Regional Healthcare
  - Greer, South Carolina, Forenede Stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - Levine Cancer Institute-Rock Hill
  - Seneca, South Carolina, Forenede Stater, 29672
    - Prisma Health Cancer Institute - Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Pierre, South Dakota, Forenede Stater, 57501
    - Avera Cancer Institute at Pierre
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Bristol, Tennessee, Forenede Stater, 37620
    - Bristol Regional Medical Center
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Memorial Hospital
  - Collierville, Tennessee, Forenede Stater, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Cookeville, Tennessee, Forenede Stater, 38501
    - Cookeville Regional Medical Center
  - Hixson, Tennessee, Forenede Stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Johnson City, Tennessee, Forenede Stater, 37604
    - Wellmont Medical Associates Oncology and Hematology-Johnson City
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Knoxville, Tennessee, Forenede Stater, 37916
    - Thompson Cancer Survival Center
  - Knoxville, Tennessee, Forenede Stater, 37932
    - Thompson Cancer Survival Center - West
  - Lenoir City, Tennessee, Forenede Stater, 37772
    - Thompson Oncology Group-Lenoir City
  - Maryville, Tennessee, Forenede Stater, 37804
    - Thompson Oncology Group-Maryville
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, Forenede Stater, 37208
    - Meharry Medical College
  - Oak Ridge, Tennessee, Forenede Stater, 37830
    - Thompson Oncology Group-Oak Ridge
  - Ooltewah, Tennessee, Forenede Stater, 37363
    - Memorial GYN Plus
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Austin, Texas, Forenede Stater, 78723
    - Dell Children's Medical Center of Central Texas
  - Austin, Texas, Forenede Stater, 78701
    - Dell Seton Medical Center at The University of Texas
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Conroe, Texas, Forenede Stater, 77384
    - MD Anderson in The Woodlands
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Edinburg, Texas, Forenede Stater, 78539
    - STCC at DHR Health Institute for Research and Development
  - Houston, Texas, Forenede Stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77079
    - MD Anderson West Houston
  - League City, Texas, Forenede Stater, 77573
    - MD Anderson League City
  - Round Rock, Texas, Forenede Stater, 78665
    - Scott and White Healthcare Round Rock
  - Sugar Land, Texas, Forenede Stater, 77478
    - MD Anderson in Sugar Land
  - Temple, Texas, Forenede Stater, 76508
    - Scott and White Memorial Hospital
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Farmington, Utah, Forenede Stater, 84025
    - Farmington Health Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Saint George, Utah, Forenede Stater, 84770
    - Saint George Regional Medical Center
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
  - South Jordan, Utah, Forenede Stater, 84009
    - South Jordan Health Center
- Vermont
  - Saint Johnsbury, Vermont, Forenede Stater, 05819
    - Norris Cotton Cancer Center-North
- Virginia
  - Bristol, Virginia, Forenede Stater, 24201
    - Wellmont Medical Associates-Bristol
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Chesapeake, Virginia, Forenede Stater, 23320
    - Cancer Specialists of Tidewater Limited
  - Gloucester, Virginia, Forenede Stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - Martinsville, Virginia, Forenede Stater, 24115
    - Sovah Health Martinsville
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Newport News, Virginia, Forenede Stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Norfolk, Virginia, Forenede Stater, 23505
    - Bon Secours DePaul Medical Center
  - Norton, Virginia, Forenede Stater, 24273
    - Southwest VA Regional Cancer Center
  - Richmond, Virginia, Forenede Stater, 23235
    - VCU Massey Cancer Center at Stony Point
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23226
    - Bon Secours Saint Mary's Hospital
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
  - Suffolk, Virginia, Forenede Stater, 23435
    - Cancer Specialists of Tidewater-Suffolk
  - Virginia Beach, Virginia, Forenede Stater, 23454
    - Peninsula Cancer Institute-Cancer Specialists of Tidewater
  - Williamsburg, Virginia, Forenede Stater, 23185
    - Peninsula Cancer Institute-Williamsburg
  - Winchester, Virginia, Forenede Stater, 22601
    - Shenandoah Oncology PC
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison Medical Center
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forenede Stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kirkland, Washington, Forenede Stater, 98034
    - Seattle Cancer Care Alliance at EvergreenHealth
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98109
    - FHCC South Lake Union
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Seattle, Washington, Forenede Stater, 98133
    - FHCC at Northwest Hospital
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Spokane, Washington, Forenede Stater, 99204
    - MultiCare Deaconess Cancer and Blood Specialty Center - Downtown
  - Spokane, Washington, Forenede Stater, 99218
    - MultiCare Deaconess Cancer and Blood Specialty Center - North
  - Spokane Valley, Washington, Forenede Stater, 99216
    - MultiCare Deaconess Cancer and Blood Specialty Center - Valley
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
  - Martinsburg, West Virginia, Forenede Stater, 25401
    - WVUH-Berkely Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden Clark Medical Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54911
    - ThedaCare Regional Cancer Center
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Duluth Clinic Ashland
  - Brookfield, Wisconsin, Forenede Stater, 53045
    - Ascension Southeast Wisconsin Hospital - Elmbrook Campus
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Fond Du Lac, Wisconsin, Forenede Stater, 54937
    - Aurora Health Center-Fond du Lac
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Ascension Saint Francis - Reiman Cancer Center
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Medford, Wisconsin, Forenede Stater, 54451
    - Aspirus Medford Hospital
  - Mequon, Wisconsin, Forenede Stater, 53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College Of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Forenede Stater, 53405
    - Ascension All Saints Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Shawano, Wisconsin, Forenede Stater, 54166
    - ThedaCare Cancer Care - Shawano
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Ascension Medical Group Southeast Wisconsin - Mayfair Road
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Puerto Rico
- - Aguadilla, Puerto Rico, 00603
    - Advance Oncology Center
  - Arecibo, Puerto Rico, 00614
    - Doctor's Cancer Center-Arecibo
  - Bayamon, Puerto Rico, 00959-5060
    - Cancer Center-Metro Medical Center Bayamon
  - Bayamon, Puerto Rico, 00961
    - Hematologia Oncologia San Pablo
  - Caguas, Puerto Rico, 00726
    - HIMA San Pablo Oncologic Hospital
  - Manati, Puerto Rico, 00674
    - Doctors Cancer Center
  - Ponce, Puerto Rico, 00716
    - Instituto Oncologia Moderna Ponce
  - San Juan, Puerto Rico, 00917
    - San Juan Community Oncology Group
  - San Juan, Puerto Rico, 00936
    - San Juan City Hospital
  - San Juan, Puerto Rico, 00920
    - Primary Care Physician Group
  - Santa Isabel, Puerto Rico, 00757
    - Centro de Hematologia y Oncologia del Sur
Tyskland
- - Berlin, Tyskland, 10117
    - Charite Humboldt - University Hospital
  - Bochum, Tyskland, 44791
    - Saint Josef-Hospital Bochum
  - Cologne, Tyskland, 50677
    - Onkologie-Cologne
  - Esslingen, Tyskland, 73730
    - Klinikum Esslingen GmbH
  - Hamburg, Tyskland, 20249
    - Hamatologisch-Onkologische Praxis Eppendorf (HOPE)
  - Leipzig, Tyskland, 04103
    - Universitaet Leipzig
  - Mannheim, Tyskland, 68167
    - Medizinische Universität
  - Monchengladbach, Tyskland, 41063
    - Kliniken Maria Hilf GmbH
  - Munchen, Tyskland, 81377
    - Medizinische Klinik Iii
  - Ulm, Tyskland, 89081
    - University Hospital Ulm
  - Wuerzburg, Tyskland, 97080
    - University Hospital Wuerzburg
- Saxony
  - Dresden, Saxony, Tyskland, 01307
    - Technical University Dresden

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

12 år og ældre (Barn, Voksen, Ældre voksen)

Tager imod sunde frivillige

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Beskrivelse

Inklusionskriterier:

Histologisk bevist stadium III colon adenokarcinom (enhver T [Tx, T1, T2, T3 eller T4], N1-2M0; inkluderer N1C); tumorer skal anses for at stamme fra tyktarmen, herunder tumorer, der strækker sig ind i/involverer tyndtarmen (f. dem ved ileocecal-ventilen)
Tilstedeværelse af mangelfuld (d) DNA mismatch reparation (dMMR); MFR-status skal vurderes ved immunhistokemi (IHC) for MMR-proteinekspression (MLH1, MSH2, MSH6, PMS2), hvor tab af et eller flere proteiner indikerer dMMR; dMMR kan bestemmes enten lokalt eller af stedvalgt referencelaboratorium; Bemærk: tab af MLH1 og PMS2 forekommer ofte sammen; formalinfikseret paraffinindlejret (FFPE) tumorvæv er påkrævet for efterfølgende retrospektiv central bekræftelse af dMMR-status
Patienter, der er kendt for at have Lynch syndrom, har vist sig at bære en specifik kimlinjemutation i et MMR-gen (MLH1, MSH2, MSH6, PMS2), og som har vist sig at være dMMR af IHC, er kvalificerede til at deltage
Tumorer skal være blevet fuldstændig resekeret; hos patienter med tumor, der klæber til tilstødende strukturer, skal en bloc R0-resektion dokumenteres i operationsrapporten eller på anden måde bekræftes af kirurgen; nære eller positive radiale marginer er acceptable, så længe en bloc resektion blev udført; proksimal eller distal margin positivitet er ikke tilladt
Hele tumoren skal være i tyktarmen (rektal involvering er en udelukkelse); kirurg bekræftelse på, at hele tumoren var lokaliseret i tyktarmen, er kun påkrævet i tilfælde, hvor det er vigtigt at fastslå, om tumoren er en tyktarm versus (vs.) rektal primær; patienter med mere end ét primært tyktarmsadenokarcinom er berettiget, hvis den kvalificerende stadium III-tumor er begrænset til tyktarmen og ikke endetarmen, og de andre kræftformer i lavere stadium fjernes i en bloc R0-resektionen
Baseret på operationsrapporten og anden kildedokumentation vil placeringen af den primære tumor blive kategoriseret som proksimal eller distal i forhold til miltbøjningen (inkluderet med distal), og yderligere kategorisering vil være som følger: blindtarm/opstigende, tværgående, faldende, sigmoid. colon eller rectosigmoid colon
Ingen tegn på resterende involveret lymfeknudesygdom eller metastatisk sygdom på registreringstidspunktet baseret på klinikerens vurdering af billeddiagnostik; den behandlende læge vil afgøre, om tilfældige læsioner på billeddannelse kræver oparbejdning for at udelukke metastatisk sygdom; hvis den behandlende læge på baggrund af gennemgang af billeder fastslår, at patienten er trin III, er patienten berettiget
Ingen forudgående medicinsk terapi (kemoterapi, immunterapi, biologisk eller målrettet terapi) eller strålebehandling for den aktuelle tyktarmskræft med undtagelse af en cyklus af mFOLFOX6
Alder >= 12 år
Ydeevnestatus:
- Patienter < 16 år: Lansky >= 50 %
- Patienter 16 til < 18 år: Karnofsky >= 50 %
- Patienter >= 18 år: Eastern Cooperative Oncology Group (ECOG) præstationsstatus =< 2
Denne undersøgelse involverer: 1) et forsøgsmiddel, hvis genotoksiske, mutagene og teratogene virkninger på det udviklende foster og nyfødte er ukendte; og 2) et middel, der har kendt genotoksiske, mutagene og teratogene virkninger; derfor, kun for kvinder i den fødedygtige alder, kræves en negativ graviditetstest udført =< 7 dage før registrering; en kvinde i den fødedygtige alder er en kønsmoden kvinde, som: 1) ikke har gennemgået en hysterektomi eller bilateral ooforektomi; eller 2) ikke har været naturligt postmenopausal i mindst 12 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 12 på hinanden følgende måneder)
Absolut neutrofiltal (ANC) >= 1500 mm^3
Blodpladetal >= 100.000 mm^3; blodplader >= 75.000 påkrævet for patienter, der modtog cyklus 1 af mFOLFOX6 før registrering
Kreatinin =< 1,5 x øvre normalgrænse (ULN) eller
Beregnet kreatininclearance >= 45 ml/min ved Cockcroft-Gault-ligning
- Alternativt, for patienter < 18 år, maksimalt serumkreatinin =< nedenstående alders-kønsspecifikke normer:
  - 12 år: 1,2 (mand og kvinde)
  - 13 til < 16 år: 1,5 (mand), 1,4 (kvinde)
  - 16 til < 18 år: 1,7 (mand), 1,4 (kvinde)
Total bilirubin =< 1,5 x øvre normalgrænse (ULN) undtagen i tilfælde af Gilberts sygdom
Aspartataminotransferase (AST)/alaninaminotransferase (ALT) =< 2,5 x øvre normalgrænse (ULN)
Skjoldbruskkirtelstimulerende hormon (TSH) inden for normale grænser (WNL); tilskud er acceptabelt for at opnå en TSH WNL; hos patienter med unormal TSH, hvis fri T4 er normal, og patienten er klinisk euthyroid, er patienten berettiget
Ingen aktiv kendt autoimmun sygdom, herunder colitis, inflammatorisk tarmsygdom (dvs. colitis ulcerosa eller Crohns sygdom), reumatoid arthritis, panhypopituitarisme, binyrebarkinsufficiens
Ingen kendt aktiv hepatitis B eller C
- Aktiv hepatitis B kan defineres som:
  - Hepatitis B-virus overfladeantigen (HBsAg) påviselig i > 6 måneder;
  - Serum hepatitis B virus (HBV) DNA 20.000 IE/ml (105 kopier/ml); lavere værdier 2.000-20.000 IE/ml (104-105 kopier/ml) ses ofte ved hepatitis B virus e antigen (HBeAg)-negativ kronisk hepatitis B
  - Vedvarende eller intermitterende stigning i ALAT/AST-niveauer
  - Leverbiopsi, der viser kronisk hepatitis med moderat eller svær nekroinflammation
- Aktiv hepatitis C kan defineres som:
  - Hepatitis C antistof (AB) positiv OG
  - Tilstedeværelse af hepatitis C-virus (HCV) RNA
Ingen grad >= 2 perifer motorisk eller sensorisk neuropati
Patienter, der er positive for human immundefektvirus (HIV) er kun kvalificerede, hvis de opfylder alle følgende:
- Et stabilt regime af højaktiv antiretroviral terapi (HAART)
- Intet krav om samtidige antibiotika eller svampedræbende midler til forebyggelse af opportunistiske infektioner
- Et CD4-tal over 250 celler/mcL og en ikke-detekterbar HIV-virusbelastning på standard polymerasekædereaktion (PCR)-baserede tests
Ingen andre planlagte samtidige undersøgelsesmidler eller anden tumorstyret terapi (kemoterapi, stråling) under studiet
Ingen systemisk daglig behandling med hverken kortikosteroider (> 10 mg daglige prednisonækvivalenter) eller anden immunsuppressiv medicin inden for 7 dage efter registrering
Ingen kendt historie med alvorlige allergiske anafylaktiske reaktioner på kimære, humane eller humaniserede antistoffer eller fusionsproteiner
Ingen kendt overfølsomhed over for kinesisk hamster ovarie (CHO) celleprodukter eller nogen komponent i atezolizumab formuleringen
Ingen kendt allergi over for 5-fluorouracil, oxaliplatin eller leucovorin

Ekskluderingskriterier:

Patienter med test, der ikke viste dMMR (tab af MMR-protein), er ikke berettiget til at deltage; patienter, hvis tumorer viser MSI-H ved PCR-baseret assay, er ikke kvalificerede til at deltage, medmindre de også har MMR-test af IHC og viser sig at have dMMR (dvs. tab af et eller flere MMR-proteiner)
Udelukket, hvis kendt aktiv lungesygdom med hypoxi defineret som:
- Iltmætning < 85 % på rumluft, eller
- Iltmætning < 88 % trods supplerende ilt

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm I (kombination kemoterapi, atezolizumab) Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV som en bolus på dag 1, derefter kontinuerligt over 46 timer på dag 1-3 i hver cyklus. Behandlingen gentages hver 14. dag i op til 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienterne får også atezolizumab IV over 30-60 minutter på dag 1 i hver cyklus, begyndende i cyklus 1 eller 2. Behandlingen gentages hver 14. dag i op til 25 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter gennemgår CT eller MR hver 6. måned i de første 2 år, derefter i 3-5 år eller indtil tegn på tilbagefald, alt efter hvad der kommer først. Patienter kan også gennemgå blodprøvetagning under hele forsøget.	Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Procedure: MR scanning Gennemgå MR Andre navne: MR Magnetisk resonans Magnetisk resonansbilledscanning Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans HR MR billeddannelse MR-scanning NMR billeddannelse NMRI Kernemagnetisk resonansbilleddannelse Magnetisk resonansbilleddannelse (MRI) sMRI Magnetisk resonansbilleddannelse (procedure) MRI'er Strukturel MR Procedure: Computertomografi Gennemgå CT Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Procedure: Bioprøvesamling Gennemgå blodprøvetagning Andre navne: Biologisk prøvesamling Bioprøve indsamlet Prøvesamling Medicin: Atezolizumab Givet IV Andre navne: Tecentriq MPDL3280A RO5541267 RG7446 MPDL 3280A MPDL 328OA MPDL-3280A MPDL328OA Medicin: Fluorouracil Givet IV Andre navne: 5-Fluracil Fluracil 5 Fluorouracil 5 Fluorouracilum 5 FU 5-fluor-2,4(1H,3H)-pyrimidindion 5-Fluorouracil 5-Fu 5FU AccuSite Carac Fluor Uracil Fluouracil Flurablastin Fluracedyl Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757 Medicin: Oxaliplatin Givet IV Andre navne: 1-OHP Dakotin Dacplat Eloxatin Ai Heng Aiheng Diaminocyclohexan Oxalatoplatin JM-83 Oxalatoplatin RP 54780 RP-54780 SR-96669 Medicin: Leucovorin Calcium Givet IV Andre navne: Wellcovorin Adinepar Calcifolin Calcium (6S)-folinat Calciumfolinat Calcium Leucovorin Calfolex Calinat Cehafolin Citofolin Citrec Citrovorum faktor Cromatonbic Folinico Dalisol Disintox Divical Ecofol Emovis Faktor, Citrovorum Flynoken A Folaren Folaxin FOLI-celle Foliben Folidan Folidar Folinac Folinat Calcium Folinsyre Calcium Salt Pentahydrat Folinoral Folinvit Foliplus Folix Imo Lederfolat Lederfolin Leucosar leukovorin Rescufolin Rescuvolin Tonofolin Folinsyre
Aktiv komparator: Arm II (kombination kemoterapi) Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV som en bolus på dag 1, derefter kontinuerligt over 46 timer på dag 1-3 i hver cyklus. Behandlingen gentages hver 14. dag i op til 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter gennemgår CT eller MR hver 6. måned i de første 2 år, derefter i 3-5 år eller indtil tegn på tilbagefald, alt efter hvad der kommer først. Patienter kan også gennemgå blodprøvetagning under hele forsøget.	Andet: Livskvalitetsvurdering Hjælpestudier Andre navne: Livskvalitetsvurdering Procedure: MR scanning Gennemgå MR Andre navne: MR Magnetisk resonans Magnetisk resonansbilledscanning Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans HR MR billeddannelse MR-scanning NMR billeddannelse NMRI Kernemagnetisk resonansbilleddannelse Magnetisk resonansbilleddannelse (MRI) sMRI Magnetisk resonansbilleddannelse (procedure) MRI'er Strukturel MR Procedure: Computertomografi Gennemgå CT Andre navne: CT KAT CAT-scanning Beregnet aksial tomografi Computerstyret aksial tomografi Computerstyret tomografi CT-scanning tomografi Computerstyret aksial tomografi (procedure) Computerstyret tomografi (CT) scanning Procedure: Bioprøvesamling Gennemgå blodprøvetagning Andre navne: Biologisk prøvesamling Bioprøve indsamlet Prøvesamling Medicin: Fluorouracil Givet IV Andre navne: 5-Fluracil Fluracil 5 Fluorouracil 5 Fluorouracilum 5 FU 5-fluor-2,4(1H,3H)-pyrimidindion 5-Fluorouracil 5-Fu 5FU AccuSite Carac Fluor Uracil Fluouracil Flurablastin Fluracedyl Fluril Fluroblastin Ribofluor Ro 2-9757 Ro-2-9757 Medicin: Oxaliplatin Givet IV Andre navne: 1-OHP Dakotin Dacplat Eloxatin Ai Heng Aiheng Diaminocyclohexan Oxalatoplatin JM-83 Oxalatoplatin RP 54780 RP-54780 SR-96669 Medicin: Leucovorin Calcium Givet IV Andre navne: Wellcovorin Adinepar Calcifolin Calcium (6S)-folinat Calciumfolinat Calcium Leucovorin Calfolex Calinat Cehafolin Citofolin Citrec Citrovorum faktor Cromatonbic Folinico Dalisol Disintox Divical Ecofol Emovis Faktor, Citrovorum Flynoken A Folaren Folaxin FOLI-celle Foliben Folidan Folidar Folinac Folinat Calcium Folinsyre Calcium Salt Pentahydrat Folinoral Folinvit Foliplus Folix Imo Lederfolat Lederfolin Leucosar leukovorin Rescufolin Rescuvolin Tonofolin Folinsyre

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Arm I (kombination kemoterapi, atezolizumab)

Patienterne får oxaliplatin IV over 2 timer og leucovorin calcium IV over 2 timer på dag 1 og fluorouracil IV som en bolus på dag 1, derefter kontinuerligt over 46 timer på dag 1-3 i hver cyklus. Behandlingen gentages hver 14. dag i op til 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienterne får også atezolizumab IV over 30-60 minutter på dag 1 i hver cyklus, begyndende i cyklus 1 eller 2. Behandlingen gentages hver 14. dag i op til 25 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter gennemgår CT eller MR hver 6. måned i de første 2 år, derefter i 3-5 år eller indtil tegn på tilbagefald, alt efter hvad der kommer først. Patienter kan også gennemgå blodprøvetagning under hele forsøget.

Andet: Livskvalitetsvurdering

Hjælpestudier

Andre navne:

Livskvalitetsvurdering

Procedure: MR scanning

Gennemgå MR

Andre navne:

MR
Magnetisk resonans
Magnetisk resonansbilledscanning
Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
HR
MR billeddannelse
MR-scanning
NMR billeddannelse
NMRI
Kernemagnetisk resonansbilleddannelse
Magnetisk resonansbilleddannelse (MRI)
sMRI
Magnetisk resonansbilleddannelse (procedure)
MRI'er
Strukturel MR

Procedure: Computertomografi

Gennemgå CT

Andre navne:

CT
KAT
CAT-scanning
Beregnet aksial tomografi
Computerstyret aksial tomografi
Computerstyret tomografi
CT-scanning
tomografi
Computerstyret aksial tomografi (procedure)
Computerstyret tomografi (CT) scanning

Procedure: Bioprøvesamling

Gennemgå blodprøvetagning

Andre navne:

Biologisk prøvesamling
Bioprøve indsamlet
Prøvesamling

Medicin: Atezolizumab

Givet IV

Andre navne:

Tecentriq
MPDL3280A
RO5541267
RG7446
MPDL 3280A
MPDL 328OA
MPDL-3280A
MPDL328OA

Medicin: Fluorouracil

Givet IV

Andre navne:

5-Fluracil
Fluracil
5 Fluorouracil
5 Fluorouracilum
5 FU
5-fluor-2,4(1H,3H)-pyrimidindion
5-Fluorouracil
5-Fu
5FU
AccuSite
Carac
Fluor Uracil
Fluouracil
Flurablastin
Fluracedyl
Fluril
Fluroblastin
Ribofluor
Ro 2-9757
Ro-2-9757

Medicin: Oxaliplatin

Givet IV

Andre navne:

1-OHP
Dakotin
Dacplat
Eloxatin
Ai Heng
Aiheng
Diaminocyclohexan Oxalatoplatin
JM-83
Oxalatoplatin
RP 54780
RP-54780
SR-96669

Medicin: Leucovorin Calcium

Givet IV

Andre navne:

Wellcovorin
Adinepar
Calcifolin
Calcium (6S)-folinat
Calciumfolinat
Calcium Leucovorin
Calfolex
Calinat
Cehafolin
Citofolin
Citrec
Citrovorum faktor
Cromatonbic Folinico
Dalisol
Disintox
Divical
Ecofol
Emovis
Faktor, Citrovorum
Flynoken A
Folaren
Folaxin
FOLI-celle
Foliben
Folidan
Folidar
Folinac
Folinat Calcium
Folinsyre Calcium Salt Pentahydrat
Folinoral
Folinvit
Foliplus
Folix
Imo
Lederfolat
Lederfolin
Leucosar
leukovorin
Rescufolin
Rescuvolin
Tonofolin
Folinsyre

Aktiv komparator: Arm II (kombination kemoterapi)

Andet: Livskvalitetsvurdering

Hjælpestudier

Andre navne:

Livskvalitetsvurdering

Procedure: MR scanning

Gennemgå MR

Andre navne:

MR
Magnetisk resonans
Magnetisk resonansbilledscanning
Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
HR
MR billeddannelse
MR-scanning
NMR billeddannelse
NMRI
Kernemagnetisk resonansbilleddannelse
Magnetisk resonansbilleddannelse (MRI)
sMRI
Magnetisk resonansbilleddannelse (procedure)
MRI'er
Strukturel MR

Procedure: Computertomografi

Gennemgå CT

Andre navne:

CT
KAT
CAT-scanning
Beregnet aksial tomografi
Computerstyret aksial tomografi
Computerstyret tomografi
CT-scanning
tomografi
Computerstyret aksial tomografi (procedure)
Computerstyret tomografi (CT) scanning

Procedure: Bioprøvesamling

Gennemgå blodprøvetagning

Andre navne:

Biologisk prøvesamling
Bioprøve indsamlet
Prøvesamling

Medicin: Fluorouracil

Givet IV

Andre navne:

5-Fluracil
Fluracil
5 Fluorouracil
5 Fluorouracilum
5 FU
5-fluor-2,4(1H,3H)-pyrimidindion
5-Fluorouracil
5-Fu
5FU
AccuSite
Carac
Fluor Uracil
Fluouracil
Flurablastin
Fluracedyl
Fluril
Fluroblastin
Ribofluor
Ro 2-9757
Ro-2-9757

Medicin: Oxaliplatin

Givet IV

Andre navne:

1-OHP
Dakotin
Dacplat
Eloxatin
Ai Heng
Aiheng
Diaminocyclohexan Oxalatoplatin
JM-83
Oxalatoplatin
RP 54780
RP-54780
SR-96669

Medicin: Leucovorin Calcium

Givet IV

Andre navne:

Wellcovorin
Adinepar
Calcifolin
Calcium (6S)-folinat
Calciumfolinat
Calcium Leucovorin
Calfolex
Calinat
Cehafolin
Citofolin
Citrec
Citrovorum faktor
Cromatonbic Folinico
Dalisol
Disintox
Divical
Ecofol
Emovis
Faktor, Citrovorum
Flynoken A
Folaren
Folaxin
FOLI-celle
Foliben
Folidan
Folidar
Folinac
Folinat Calcium
Folinsyre Calcium Salt Pentahydrat
Folinoral
Folinvit
Foliplus
Folix
Imo
Lederfolat
Lederfolin
Leucosar
leukovorin
Rescufolin
Rescuvolin
Tonofolin
Folinsyre

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Sygdomsfri overlevelse (DFS) Tidsramme: Fra tiden fra randomisering til første dokumentation for tilbagevendende sygdom eller død, vurderet op til 5 år	DFS vil blive sammenlignet mellem behandlingsarme ved hjælp af den stratificerede log-rangtest på ensidigt niveau 0,025. Hvis der observeres nul DFS-hændelser i et bestemt stratum ved en interimanalyse, og der anvendes ustratificeret log-rang, vil alle efterfølgende analyser for DFS bruge ustratificeret log-rank test. Hazard ratio (HR) for DFS vil blive estimeret ved hjælp af en stratificeret Cox proportional hazards model, og 95 procent konfidensintervallet (CI) for HR vil blive angivet. Resultater fra en ikke-stratificeret analyse vil også blive leveret. Kaplan-Meier-metoden vil blive brugt til at estimere median-DFS for hver behandlingsarm, og Kaplan-Meier-kurver vil blive produceret. Brookmeyer Crowley-metoden vil blive brugt til at konstruere 95 procent CI for median DFS for hver behandlingsarm.	Fra tiden fra randomisering til første dokumentation for tilbagevendende sygdom eller død, vurderet op til 5 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Samlet overlevelse Tidsramme: Fra tidspunktet fra randomisering til død, uanset årsag, vurderet op til 5 år	Fordelingen af den samlede overlevelse vil blive estimeret ved hjælp af metoden fra Kaplan-Meier. Samlet overlevelse vil kun blive sammenlignet mellem behandlingsarme ved brug af log-rank test, hvis DFS er statistisk signifikant. HR for OS vil blive estimeret ved hjælp af en Cox proportional hazards model, og 95 procent CI for HR vil blive leveret. Hvis der anvendes en stratificeret log-rank test, vil stratificeret HR blive overvejet, og hvis en ikke-stratificeret log-rank test vil blive overvejet.	Fra tidspunktet fra randomisering til død, uanset årsag, vurderet op til 5 år
Forekomst af uønskede hændelser Tidsramme: Op til 30 dage efter sidste behandling	Vurderet ved fælles terminologikriterier for uønskede hændelser version 4.0. Frekvenstabeller vil blive gennemgået for at bestemme mønstrene. De overordnede bivirkningsrater vil blive sammenlignet mellem behandlingsarme ved hjælp af Chi-square-test (eller Fishers eksakte test, hvis dataene i beredskabstabellen er sparsomme).	Op til 30 dage efter sidste behandling

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Efterforskere

Ledende efterforsker: Frank A Sinicrope, Alliance for Clinical Trials in Oncology

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

16. oktober 2017

Primær færdiggørelse (Anslået)

2. april 2025

Studieafslutning (Anslået)

2. april 2025

Datoer for studieregistrering

Først indsendt

22. september 2016

Først indsendt, der opfyldte QC-kriterier

22. september 2016

Først opslået (Anslået)

23. september 2016

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

4. april 2024

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

3. april 2024

Sidst verificeret

1. april 2024

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

NCI-2016-01417 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
U10CA180821 (U.S. NIH-bevilling/kontrakt)
A021502 (Anden identifikator: CTEP)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Lynch syndrom

M.D. Anderson Cancer Center
National Cancer Institute (NCI)

Afsluttet

Cykling i forebyggelse af tyktarmskræft hos deltagere med Lynch-syndrom

Højfrekvent mikrosatellit-ustabilitet | Mismatch Repair Genmutation | Mutationsnegativt Lynch-syndrom | Mutationspositivt Lynch-syndrom

Forenede Stater
Tel-Aviv Sourasky Medical Center
Rambam Health Care Campus; Rabin Medical Center; Sheba Medical Center; Soroka...

Ikke rekrutterer endnu

At finde den bedste dosis af aspirin til at forhindre Lynch Syndrome Cancers (CaPP3 Israel)

Lynch syndrom I (stedsspecifik tyktarmskræft)

Israel
San Raffaele University
Unita' di Gastroenterologia - Policlinico Universitario di Bari; Unita'... og andre samarbejdspartnere

Rekruttering

Videokapsel-endoskopi ved Lynch-syndrom

Lynch syndrom | MLH1-genmutation | MSH2 genmutation | MSH6 genmutation | PMS2 genmutation | Lynch syndrom II | Tyndtarmsadenokarcinom | Lynch Syndrome I

Italien
National Cancer Institute (NCI)

Rekruttering

Kræftforebyggende vaccine Nous-209 til Lynch-syndrompatienter

Lynch syndrom

Forenede Stater, Puerto Rico
Assistance Publique - Hôpitaux de Paris

Rekruttering

Karakterisering af fækal mikrobiota i Lynch Syndrom (LS) patienter med eller uden kolorektal neoplasi (Microbiote)

Lynch syndrom

Frankrig
Imperial College London

Tilmelding efter invitation

Koloskopikontrol hos mennesker med Lynch-syndrom

Lynch syndrom

Det Forenede Kongerige
Second Affiliated Hospital, School of Medicine,...

Afsluttet

Diagnosis of Lynch Syndrome Based on Next-generation Sequencing in Patients Meeting Chinese Lynch Syndrome Criteria

Lynch syndrom

Kina
Hospital Clinic of Barcelona
Fundacion Clinic per a la Recerca Biomédica

Afsluttet

High Definition White-Light Coloscopy vs. Chromoendoscopy for Surveillance of Lynch Syndrome. (EndoLynch)

Lynch syndrom

Spanien
PERROD Guillaume

Ikke rekrutterer endnu

CAD-EYE-system til påvisning af neoplastiske læsioner hos patienter med Lynch-syndrom (CADLYNCH)

Lynch syndrom
UNC Lineberger Comprehensive Cancer Center
University of North Carolina, Chapel Hill; National Center for Advancing... og andre samarbejdspartnere

Rekruttering

Overvindelse af barrierer for optagelsen af kaskadescreening for Lynch-syndrom: gennemførlighedsundersøgelse af arbejdsbog

Lynch syndrom

Forenede Stater

Kliniske forsøg med Livskvalitetsvurdering

Seoul National University Hospital

Trukket tilbage

Virkninger af præoperativ angst og depression på kortsigtet postoperativ restitution ved tidlig gastrisk cancer

Depression | Postoperative komplikationer | Angst | Mestringsadfærd

Korea, Republikken
Memorial Sloan Kettering Cancer Center

Afsluttet

Indvirkning af palliativ kateterplacering på livskvaliteten for patienter med refraktær ascites

Ascites

Forenede Stater
Latin American Cooperative Oncology Group
Roche Pharma AG; EVA - Grupo Brasileiro de Tumores Ginecológicos

Afsluttet

Prospektiv evaluering af patienter med livmoderhalskræft i brasilianske sundhedsinstitutioner - EVITA I-undersøgelsen

Livmoderhalskræft

Brasilien
Kutahya Health Sciences University

Afsluttet

Tyrkisk gyldighed og pålidelighed af smertekatastrofiserende scale-Child (PCS-C)

Kronisk smerte | Juvenil idiopatisk arthritis

Kalkun
University of Florida

Afsluttet

Medlidenhedstræthed hos ED-udbydere

Medfølelse Træthed

Forenede Stater
Maastricht University
TNO; Netherlands Instititute for Health Services Research; University of...

Afsluttet

Effektivitet og implementering af værktøjet til vurdering af byrde ved kroniske lidelser (ABCC)

Hjertefejl | Diabetes mellitus, type 2 | Kronisk obstruktiv lungesygdom | Astma

Holland
World Vision Canada
Ryerson University; World Health Organization; Global Affairs Canada; Ministry...

Afsluttet

Klinisk evaluering af brugen af en mHealth-intervention om plejekvalitet

Diarré | Malaria | Akut luftvejsinfektion
University Hospital, Strasbourg, France

Afsluttet

Validering af en pædiatrisk billedversion af QOR-15 Postoperatory Functional Recovery Scale - QoR-15 Pédiatric

Kirurgisk indgreb | Mindre

Frankrig
King's College London
Guy's and St Thomas' NHS Foundation Trust

Afsluttet

Livskvalitetsværktøj til IBD (QOLITI)

Inflammatorisk tarmsygdom

Det Forenede Kongerige
Ondokuz Mayıs University
Samsun Education and Research Hospital

Afsluttet

Tyrkisk gyldighed og pålidelighed af Recovery Scale QoR-15 (Qor-15)

Sundhedsadfærd

Kalkun

Kombinationskemoterapi med eller uden atezolizumab til behandling af patienter med trin III tyktarmskræft og mangelfuld DNA mismatch reparation

Randomiseret forsøg med standard kemoterapi alene eller kombineret med atezolizumab som adjuverende terapi til patienter med trin III tyktarmskræft og mangelfuld DNA mismatch reparation

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Anslået)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Anslået)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Kliniske forsøg med Lynch syndrom

Kliniske forsøg med Livskvalitetsvurdering

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Oman

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer