- ICH GCP
- US Clinical Trials Registry
- Klinisk forsøg NCT02928913
The Associations Between Sedentary Behaviour and Impact Characteristics on Bone Health
Studieoversigt
Detaljeret beskrivelse
Significant proportions of adults engage in sedentary behaviour for prolonged periods of time which is generally regarded as having deleterious effects on health. However, far less is known about its specific effects on bone health. Exercise has been proposed as a method of improving bone health, as impact forces generated as the foot contacts the ground during physical activity have the potential to aid bone maintenance and development.
The properties of bone are regulated through the amount mechanical loading, frequency of loading and duration of loading endured, which can create an osteogenic effect. These variables can be quantified via accelerometry which records the magnitude, rate and duration of accelerations experienced at the site on the body where the accelerometer is worn. Although there is a vast amount of literature where accelerometers have been used to monitor physical activity, there is a lack of studies that use accelerometers to determine the most effective exercise for bone, especially in relation to the lumbar spine. Exploring the bone health and loading characteristics of sedentary and low and highly active non-sedentary individuals will provide evidence upon which to base future interventions that are likely to be of benefit for bone health in sedentary populations.
Undersøgelsestype
Tilmelding (Faktiske)
Kontakter og lokationer
Studiesteder
-
-
West Midlands
-
Walsall, West Midlands, Det Forenede Kongerige, WS1 3BD
- University of Wolverhampton
-
-
Deltagelseskriterier
Berettigelseskriterier
Aldre berettiget til at studere
Tager imod sunde frivillige
Køn, der er berettiget til at studere
Prøveudtagningsmetode
Studiebefolkning
Beskrivelse
Inclusion Criteria:
Male or female aged 30 - 60 years Individuals who are sedentary and do not participate in physical activities Individuals who participate in some physical activities Individuals who are highly active Must be free from injury or illness that will affects following typical weekly routines.
Exclusion Criteria:
Any medical condition that affects bone health, e.g. osteoporosis. Currently takes medication that affects bone health, e.g. long term steroid use.
Inability to participate in typical daily activity, e.g. severe arthritis, injury. Women who are post menopause Women who are on hormone replacement therapy Unable to participate in DXA scan, e.g. due to recent exposure to radiation, pregnancy status.
Studieplan
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
Kohorter og interventioner
Gruppe / kohorte |
Intervention / Behandling |
|---|---|
|
Sedentary
Predominantly engage in sedentary behaviours
|
|
|
Non-sedentary
Predominantly engage in non-sedentary behaviours
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Bone mineral density
Tidsramme: One day
|
One day
|
Sekundære resultatmål
Resultatmål |
Tidsramme |
|---|---|
|
Mechanical loading dose during daily activity via accelerometry
Tidsramme: 7 days
|
7 days
|
|
Mechanical loading intensity during daily activity via accelerometry
Tidsramme: 7 days
|
7 days
|
|
Functional movement assessment: Grip Strength
Tidsramme: One day
|
One day
|
|
Functional movement assessment: Timed up and go
Tidsramme: One day
|
One day
|
|
Functional movement assessment: 10m walk test
Tidsramme: One day
|
One day
|
|
Functional movement assessment: 5 times sit to stand
Tidsramme: One day
|
One day
|
|
Functional movement assessment: gait analysis (acceleration at hip and lumbar spine)
Tidsramme: One day
|
One day
|
|
Functional movement assessment: gait analysis (ground reaction force)
Tidsramme: One day
|
One day
|
Samarbejdspartnere og efterforskere
Sponsor
Samarbejdspartnere
Datoer for undersøgelser
Studer store datoer
Studiestart (Faktiske)
Primær færdiggørelse (Faktiske)
Studieafslutning (Faktiske)
Datoer for studieregistrering
Først indsendt
Først indsendt, der opfyldte QC-kriterier
Først opslået (Skøn)
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Faktiske)
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
Sidst verificeret
Mere information
Begreber relateret til denne undersøgelse
Nøgleord
Andre undersøgelses-id-numre
- 01/0416/TS/UOW
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .