The Associations Between Sedentary Behaviour and Impact Characteristics on Bone Health

To investigate associations between sedentary and active behaviour with bone health and functional ability, and to associate mechanical loading at the lumbar spine and hip in sedentary and active individuals with bone mineral density.

Study Overview

• Status: Completed
• Conditions: Bone Health
• Intervention / Treatment: Other: No intervention

Detailed Description

Significant proportions of adults engage in sedentary behaviour for prolonged periods of time which is generally regarded as having deleterious effects on health. However, far less is known about its specific effects on bone health. Exercise has been proposed as a method of improving bone health, as impact forces generated as the foot contacts the ground during physical activity have the potential to aid bone maintenance and development.

The properties of bone are regulated through the amount mechanical loading, frequency of loading and duration of loading endured, which can create an osteogenic effect. These variables can be quantified via accelerometry which records the magnitude, rate and duration of accelerations experienced at the site on the body where the accelerometer is worn. Although there is a vast amount of literature where accelerometers have been used to monitor physical activity, there is a lack of studies that use accelerometers to determine the most effective exercise for bone, especially in relation to the lumbar spine. Exploring the bone health and loading characteristics of sedentary and low and highly active non-sedentary individuals will provide evidence upon which to base future interventions that are likely to be of benefit for bone health in sedentary populations.

• Study Type: Observational
• Enrollment (Actual): 56

Contacts and Locations

Study Locations

• United Kingdom
  • West Midlands
    • Walsall, West Midlands, United Kingdom, WS1 3BD
      • University of Wolverhampton

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 30 years to 60 years (Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Sedentary and non-sedentary populations.

Description

Inclusion Criteria:

Male or female aged 30 - 60 years Individuals who are sedentary and do not participate in physical activities Individuals who participate in some physical activities Individuals who are highly active Must be free from injury or illness that will affects following typical weekly routines.

Exclusion Criteria:

Any medical condition that affects bone health, e.g. osteoporosis. Currently takes medication that affects bone health, e.g. long term steroid use.

Inability to participate in typical daily activity, e.g. severe arthritis, injury. Women who are post menopause Women who are on hormone replacement therapy Unable to participate in DXA scan, e.g. due to recent exposure to radiation, pregnancy status.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Sedentary; Predominantly engage in sedentary behaviours	Other: No intervention
Non-sedentary; Predominantly engage in non-sedentary behaviours	Other: No intervention

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Bone mineral density	One day

Secondary Outcome Measures

Outcome Measure	Time Frame
Mechanical loading dose during daily activity via accelerometry	7 days
Mechanical loading intensity during daily activity via accelerometry	7 days
Functional movement assessment: Grip Strength	One day
Functional movement assessment: Timed up and go	One day
Functional movement assessment: 10m walk test	One day
Functional movement assessment: 5 times sit to stand	One day
Functional movement assessment: gait analysis (acceleration at hip and lumbar spine)	One day
Functional movement assessment: gait analysis (ground reaction force)	One day

Collaborators and Investigators

• Sponsor: Dr Tina Smith
• Collaborators: London South Bank University

Study record dates

Study Major Dates

• Study Start (Actual): May 1, 2016
• Primary Completion (Actual): July 1, 2017
• Study Completion (Actual): July 1, 2017

Study Registration Dates

• First Submitted: October 5, 2016
• First Submitted That Met QC Criteria: October 6, 2016
• First Posted (Estimate): October 10, 2016

Study Record Updates

• Last Update Posted (Actual): October 26, 2017
• Last Update Submitted That Met QC Criteria: October 25, 2017
• Last Verified: October 1, 2017

More Information

Terms related to this study

• Keywords: sedentary; non-sedentary; populations
• Other Study ID Numbers: 01/0416/TS/UOW