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Durvalumab og Tremelimumab til behandling af patienter med tilbagevendende fase IV lungekræft

7. juni 2023 opdateret af: SWOG Cancer Research Network

Et fase II-studie af MEDI4736 (Durvalumab) Plus Tremelimumab som terapi til patienter med tidligere behandlet anti-PD-1/PD-L1-resistent trin IV planocellulært lungekræft (Lung-Map Non-Match Sub-Studie)

Dette fase II-forsøg undersøger, hvor godt durvalumab og tremelimumab virker ved behandling af patienter med stadium IV-lungekræft, som er kommet tilbage efter tidligere behandling. Monoklonale antistoffer, såsom durvalumab og tremelimumab, kan interferere med tumorcellers evne til at vokse og sprede sig.

Studieoversigt

Status

Afsluttet

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. At evaluere den objektive responsrate (bekræftet og ubekræftet, fuldstændig og delvis) ved responsevalueringskriterier i solide tumorer (RECIST) 1.1 blandt patienter behandlet med durvalumab (MEDI4736) plus tremelimumab.

SEKUNDÆRE MÅL:

I. At estimere varigheden af respons (DoR) blandt patienter, der opnår et komplet respons (CR) eller delvist respons (PR) (bekræftet og ubekræftet) af RECIST 1.1.

II. At estimere varigheden af respons (DoR) pr. immunrelaterede responskriterier blandt patienter, der opnår et komplet respons (CR) eller delvist respons (PR) (bekræftet og ubekræftet) af RECIST 1.1.

III. At evaluere den samlede overlevelse (OS) blandt patienter behandlet med durvalumab (MEDI4736) plus tremelimumab.

IV. At evaluere investigator-vurderet progressionsfri overlevelse (IA-PFS) blandt patienter behandlet med durvalumab (MEDI4736) plus tremelimumab.

V. At evaluere IA-PFS vurderet ved immunrelaterede responskriterier (irRC-IA-PFS) blandt patienter behandlet med durvalumab (MEDI4736) plus tremelimumab.

VI. At evaluere hyppigheden og sværhedsgraden af toksiciteter forbundet med durvalumab (MEDI4736) plus tremelimumab.

TERTIÆRE MÅL:

I. At udforske sammenhængen mellem potentielle prædiktive markører identificeret i S1400A med respons og progressionsfri overlevelse (PFS).

II. At udforske sammenhængen mellem PD-L1-ekspressionsstatus med respons og PFS.

III. At bidrage til en løbende serum- og tumorbank i S1400.

OMRIDS:

Patienterne får tremelimumab intravenøst (IV) i løbet af 60 minutter på dag 1 for forløb 1-4 og durvalumab IV over 60 minutter på dag 1. Kurser gentages hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne hver 6. måned i 2 år og derefter i slutningen af år 3.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

Fase

Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center-North Campus
  - Tucson, Arizona, Forenede Stater, 85724
    - The University of Arizona Medical Center-University Campus
- Arkansas
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - Mercy Cancer Center-Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - Fowler Family Center for Cancer Care
- California
  - Anaheim, California, Forenede Stater, 92807
    - Kaiser Permanente-Anaheim
  - Antioch, California, Forenede Stater, 94531
    - Kaiser Permanente-Deer Valley Medical Center
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Bakersfield, California, Forenede Stater, 93301
    - AIS Cancer Center at San Joaquin Community Hospital
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Corona, California, Forenede Stater, 92879
    - City of Hope Corona
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente Hospital
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Fresno, California, Forenede Stater, 93720
    - Kaiser Permanente
  - Fullerton, California, Forenede Stater, 92835
    - Saint Jude Medical Center
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente - Harbor City
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - Lancaster, California, Forenede Stater, 93534
    - City of Hope Antelope Valley
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente-Cadillac
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Mission Hills, California, Forenede Stater, 91345
    - City of Hope Mission Hills
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Paradise, California, Forenede Stater, 95969
    - Feather River Cancer Center
  - Pismo Beach, California, Forenede Stater, 93449
    - PCR Oncology
  - Rancho Cucamonga, California, Forenede Stater, 91730
    - City of Hope Rancho Cucamonga
  - Rancho Mirage, California, Forenede Stater, 92270
    - Eisenhower Medical Center
  - Redwood City, California, Forenede Stater, 94063
    - Kaiser Permanente-Redwood City
  - Richmond, California, Forenede Stater, 94801
    - Kaiser Permanente-Richmond
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - Sacramento, California, Forenede Stater, 95825
    - Kaiser Permanente - Sacramento
  - Saint Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Diego, California, Forenede Stater, 92108
    - Kaiser Permanente-San Diego Mission
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forenede Stater, 92069
    - Kaiser Permanente-San Marcos
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser Permanente-San Rafael
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - South Pasadena, California, Forenede Stater, 91030
    - City of Hope South Pasadena
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Stockton, California, Forenede Stater, 95210
    - Kaiser Permanente-Stockton
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Truckee, California, Forenede Stater, 96161
    - Gene Upshaw Memorial Tahoe Forest Cancer Center
  - Vacaville, California, Forenede Stater, 95688
    - Kaiser Permanente Medical Center-Vacaville
  - Vacaville, California, Forenede Stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Whittier, California, Forenede Stater, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente
- Colorado
  - Aurora, Colorado, Forenede Stater, 80045
    - University of Colorado Hospital
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Boulder, Colorado, Forenede Stater, 80301
    - Boulder Community Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - Memorial Hospital Central
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80206
    - National Jewish Health-Main Campus
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - Southwest Oncology PC
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Comprehensive Cancer Care and Research Institute of Colorado LLC
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Golden, Colorado, Forenede Stater, 80401
    - Mountain Blue Cancer Care Center
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Greenwood Village, Colorado, Forenede Stater, 80111
    - Rocky Mountain Cancer Centers-Greenwood Village
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Parker, Colorado, Forenede Stater, 80138
    - Rocky Mountain Cancer Centers-Parker
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Pueblo, Colorado, Forenede Stater, 81008
    - Rocky Mountain Cancer Centers - Pueblo
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forenede Stater, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Connecticut
  - Derby, Connecticut, Forenede Stater, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, Forenede Stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Guilford, Connecticut, Forenede Stater, 06437
    - Medical Oncology and Hematology Group PC-Guilford
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Meriden, Connecticut, Forenede Stater, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - New Haven, Connecticut, Forenede Stater, 06510
    - Smilow Cancer Center/Yale-New Haven Hospital
  - North Haven, Connecticut, Forenede Stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Norwich, Connecticut, Forenede Stater, 06360
    - Eastern Connecticut Hematology and Oncology Associates
  - Orange, Connecticut, Forenede Stater, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Torrington, Connecticut, Forenede Stater, 06790
    - Charlotte Hungerford Hospital Center for Cancer Care
  - Trumbull, Connecticut, Forenede Stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, Forenede Stater, 06385
    - Lawrence and Memorial Cancer Center
  - West Haven, Connecticut, Forenede Stater, 06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Newark, Delaware, Forenede Stater, 19713
    - Regional Hematology and Oncology PA
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - Nanticoke Memorial Hospital
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington, District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
  - Washington, District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
  - Washington, District of Columbia, Forenede Stater, 20002
    - Kaiser Permanente-Capitol Hill Medical Center
- Florida
  - Aventura, Florida, Forenede Stater, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Coral Gables, Florida, Forenede Stater, 33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Daytona Beach, Florida, Forenede Stater, 32114
    - Halifax Health Medical Center-Centers for Oncology
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Hollywood, Florida, Forenede Stater, 33021
    - UM Sylvester Comprehensive Cancer Center at Hollywood
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - Memorial Hospital West
  - Plantation, Florida, Forenede Stater, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center
- Georgia
  - Albany, Georgia, Forenede Stater, 31701
    - Phoebe Putney Memorial Hospital
  - Athens, Georgia, Forenede Stater, 30607
    - University Cancer and Blood Center LLC
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Atlanta, Georgia, Forenede Stater, 30342
    - Saint Joseph's Hospital of Atlanta
  - Augusta, Georgia, Forenede Stater, 30912
    - Augusta University Medical Center
  - Columbus, Georgia, Forenede Stater, 31904
    - John B Amos Cancer Center
  - Cumming, Georgia, Forenede Stater, 30041
    - Northside Hospital-Forsyth
  - Decatur, Georgia, Forenede Stater, 30033
    - Dekalb Medical Center
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Forenede Stater, 30045
    - Gwinnett Medical Center
  - Macon, Georgia, Forenede Stater, 31201
    - Medical Center of Central Georgia
  - Macon, Georgia, Forenede Stater, 31201
    - Central Georgia Gynecologic Oncology
  - Rome, Georgia, Forenede Stater, 30165
    - Harbin Clinic Medical Oncology and Clinical Research
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial University Medical Center
  - Savannah, Georgia, Forenede Stater, 31404
    - Summit Cancer Care-Memorial
  - Savannah, Georgia, Forenede Stater, 31405
    - Low Country Cancer Care Associates PC
  - Valdosta, Georgia, Forenede Stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
  - 'Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Oncology Inc-Pali Momi
  - 'Ewa Beach, Hawaii, Forenede Stater, 96706
    - The Cancer Center of Hawaii-Leeward
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - The Cancer Center of Hawaii-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96813
    - University of Hawaii Cancer Center
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Cancer Care Inc-Liliha
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Kuakini Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96826
    - Kapiolani Medical Center for Women and Children
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Island Urology
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc-POB II
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Oncology Inc-POB I
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Hawaii Oncology Inc-Kuakini
  - Lihue, Hawaii, Forenede Stater, 96766
    - Wilcox Memorial Hospital and Kauai Medical Clinic
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Mountain States Tumor Institute
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Medical Center
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Mountain States Tumor Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Mountain States Tumor Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Alphonsus Medical Center-Nampa
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Mountain States Tumor Institute - Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Cancer Center
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Cancer Clinic
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Mountain States Tumor Institute-Twin Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forenede Stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - John H Stroger Jr Hospital of Cook County
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Danville, Illinois, Forenede Stater, 61832
    - Carle on Vermilion
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Center of Decatur
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Elk Grove Village, Illinois, Forenede Stater, 60007
    - AMITA Health Alexian Brothers Medical Center
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Evanston, Illinois, Forenede Stater, 60202
    - Saint Francis Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Hinsdale, Illinois, Forenede Stater, 60521
    - AMITA Health Cancer Institute and Outpatient Center
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Moline, Illinois, Forenede Stater, 61265
    - Trinity Medical Center
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - Naperville, Illinois, Forenede Stater, 60540
    - Hematology Oncology Consultants Limited
  - New Lenox, Illinois, Forenede Stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - Orland Park, Illinois, Forenede Stater, 60462
    - University of Chicago Medicine-Orland Park
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Pekin, Illinois, Forenede Stater, 61554
    - OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
  - Peoria, Illinois, Forenede Stater, 61637
    - OSF Saint Francis Medical Center
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peoria, Illinois, Forenede Stater, 61615
    - OSF Saint Francis Radiation Oncology at Peoria Cancer Center
  - Peoria, Illinois, Forenede Stater, 61603
    - Methodist Medical Center of Illinois
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Skokie, Illinois, Forenede Stater, 60076
    - North Shore Medical Center
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Swansea, Illinois, Forenede Stater, 62226
    - Cancer Care Specialists of Illinois-Swansea
  - Swansea, Illinois, Forenede Stater, 62226
    - Memorial and Saint Elizabeth's Health Care Services LLP
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Forenede Stater, 46032
    - IU Health North Hospital
  - Evansville, Indiana, Forenede Stater, 47713
    - Deaconess Clinic Downtown
  - Indianapolis, Indiana, Forenede Stater, 46237
    - Franciscan Health Indianapolis
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Richard L. Roudebush Veterans Affairs Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46290
    - Springmill Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - IU Health Methodist Hospital
  - Michigan City, Indiana, Forenede Stater, 46360
    - Franciscan Saint Anthony Health-Michigan City
  - Michigan City, Indiana, Forenede Stater, 46360
    - Woodland Cancer Care Center
  - Mishawaka, Indiana, Forenede Stater, 46545
    - Memorial Regional Cancer Center Day Road
  - Mooresville, Indiana, Forenede Stater, 46158
    - Franciscan Health Mooresville
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Newburgh, Indiana, Forenede Stater, 47630
    - Chancellor Center for Oncology
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - Terre Haute, Indiana, Forenede Stater, 47804
    - Union Hospital
- Iowa
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Des Moines, Iowa, Forenede Stater, 50314
    - Medical Oncology and Hematology Associates-Laurel
  - Fairfield, Iowa, Forenede Stater, 52556
    - JCHC McCreery Cancer Center
  - Ottumwa, Iowa, Forenede Stater, 52501
    - Ottumwa Regional Health Center
  - Waterloo, Iowa, Forenede Stater, 50702
    - Covenant Medical Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Emporia, Kansas, Forenede Stater, 66801
    - Newman Regional Health
  - Fort Scott, Kansas, Forenede Stater, 66701
    - Cancer Center of Kansas - Fort Scott
  - Garden City, Kansas, Forenede Stater, 67846
    - Saint Catherine Hospital
  - Great Bend, Kansas, Forenede Stater, 67530
    - Heartland Cancer Center
  - Hays, Kansas, Forenede Stater, 67601
    - Hays Medical Center
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kansas City, Kansas, Forenede Stater, 66160
    - University of Kansas Cancer Center
  - Kansas City, Kansas, Forenede Stater, 66112
    - University of Kansas Cancer Center-West
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forenede Stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forenede Stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Medical Center
  - Overland Park, Kansas, Forenede Stater, 66210
    - University of Kansas Cancer Center-Overland Park
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Via Christi Hospital-Pittsburg
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Cancer Center / Stormont Vail Health
  - Topeka, Kansas, Forenede Stater, 66606
    - Saint Francis Hospital and Medical Center - Topeka
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Westwood, Kansas, Forenede Stater, 66205
    - University of Kansas Hospital-Westwood Cancer Center
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Associates In Womens Health
  - Wichita, Kansas, Forenede Stater, 67214
    - Via Christi Regional Medical Center
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - King's Daughter's Medical Center
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Elizabethtown, Kentucky, Forenede Stater, 42701
    - Hardin Memorial Hospital
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Louisville, Kentucky, Forenede Stater, 40245
    - Jewish Hospital Medical Center Northeast
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Paducah, Kentucky, Forenede Stater, 42003
    - Baptist Health Paducah
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70805
    - LSU Health Baton Rouge-North Clinic
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Ochsner Health Center-Summa
  - Baton Rouge, Louisiana, Forenede Stater, 70806
    - Baton Rouge General Medical Center
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Hematology/Oncology Clinic LLP
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Medical Oncology LLC
  - Covington, Louisiana, Forenede Stater, 70433
    - Mary Bird Cancer Center/Saint Tammany Parish
  - Covington, Louisiana, Forenede Stater, 70433
    - North Shore Hematology Oncology Associates Inc
  - Houma, Louisiana, Forenede Stater, 70360
    - Mary Bird Perkins Cancer Center/Terrebonne General Medical Center
  - Houma, Louisiana, Forenede Stater, 70360
    - Oncology Center of The South Incorporated
  - Kenner, Louisiana, Forenede Stater, 70065
    - Ochsner Medical Center Kenner
  - Metairie, Louisiana, Forenede Stater, 70006
    - East Jefferson General Hospital
  - Metairie, Louisiana, Forenede Stater, 70006
    - Robert Veith MD LLC
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Tulane University Health Sciences Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - New Orleans, Louisiana, Forenede Stater, 70115
    - LSU Healthcare Network/Saint Charles
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Portland, Maine, Forenede Stater, 04101
    - Mercy Hospital
  - Rockport, Maine, Forenede Stater, 04856
    - Penobscot Bay Medical Center
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21237
    - MedStar Franklin Square Medical Center/Weinberg Cancer Institute
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21201
    - University of Maryland/Greenebaum Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21218
    - MedStar Union Memorial Hospital
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Baltimore, Maryland, Forenede Stater, 21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Bel Air, Maryland, Forenede Stater, 21014
    - Upper Chesapeake Medical Center
  - Cumberland, Maryland, Forenede Stater, 21502
    - Western Maryland Regional Medical Center
  - Frederick, Maryland, Forenede Stater, 21701
    - Frederick Memorial Hospital
  - Gaithersburg, Maryland, Forenede Stater, 20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Kensington, Maryland, Forenede Stater, 20895
    - Kaiser Permanente - Kensington Medical Center
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente - Largo Medical Center
  - Olney, Maryland, Forenede Stater, 20832
    - Montgomery General Hospital-Olney
  - Randallstown, Maryland, Forenede Stater, 21133
    - Northwest Hospital Center
  - Salisbury, Maryland, Forenede Stater, 21801
    - Peninsula Regional Medical Center
  - Westminster, Maryland, Forenede Stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Fitchburg, Massachusetts, Forenede Stater, 01420
    - Simonds-Sinon Regional Cancer Center
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
  - Winchester, Massachusetts, Forenede Stater, 01890
    - Winchester Hospital
  - Worcester, Massachusetts, Forenede Stater, 01655
    - University of Massachusetts Medical School
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48106-0995
    - Saint Joseph Mercy Hospital
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forenede Stater, 48114
    - Saint Joseph Mercy Brighton
  - Brighton, Michigan, Forenede Stater, 48114
    - IHA Hematology Oncology Consultants-Brighton
  - Brownstown, Michigan, Forenede Stater, 48183
    - Henry Ford Cancer Institute?Downriver
  - Canton, Michigan, Forenede Stater, 48188
    - IHA Hematology Oncology Consultants-Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Saint Joseph Mercy Canton Health Center
  - Caro, Michigan, Forenede Stater, 48723
    - Caro Cancer Center
  - Chelsea, Michigan, Forenede Stater, 48118
    - Saint Joseph Mercy Chelsea
  - Chelsea, Michigan, Forenede Stater, 48118
    - IHA Hematology Oncology Consultants-Chelsea
  - Clarkston, Michigan, Forenede Stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Newland Medical Associates-Clarkston
  - Clinton Township, Michigan, Forenede Stater, 48038
    - Henry Ford Macomb Hospital-Clinton Township
  - Dearborn, Michigan, Forenede Stater, 48126
    - Henry Ford Medical Center-Fairlane
  - Dearborn, Michigan, Forenede Stater, 48124
    - Beaumont Hospital-Dearborn
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital
  - Detroit, Michigan, Forenede Stater, 48236
    - Saint John Hospital and Medical Center
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - East China Township, Michigan, Forenede Stater, 48054
    - Great Lakes Cancer Management Specialists-Doctors Park
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Farmington, Michigan, Forenede Stater, 48334
    - Botsford General Hospital
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Flint, Michigan, Forenede Stater, 48502
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Cancer and Blood Disease Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Mercy Health Saint Mary's
  - Grosse Pointe, Michigan, Forenede Stater, 48230
    - William Beaumont Hospital-Grosse Point
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Michigan Breast Specialists-Grosse Pointe Woods
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Lymphoma Clinic of Michigan
  - Jackson, Michigan, Forenede Stater, 49201
    - Allegiance Health
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49001
    - Borgess Medical Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Saint Mary Mercy Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forenede Stater, 48044
    - Michigan Breast Specialists-Macomb Township
  - Macomb, Michigan, Forenede Stater, 48044
    - Hematology Oncology Associates East PC
  - Midland, Michigan, Forenede Stater, 48670
    - Mid-Michigan Medical Center - Midland
  - Monroe, Michigan, Forenede Stater, 48162
    - Monroe Cancer Center
  - Muskegon, Michigan, Forenede Stater, 49444
    - Mercy Health Mercy Campus
  - Niles, Michigan, Forenede Stater, 49120
    - Lakeland Community Hospital
  - Novi, Michigan, Forenede Stater, 48377
    - Henry Ford Medical Center-Columbus
  - Novi, Michigan, Forenede Stater, 48374-1236
    - Assarian Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Pontiac, Michigan, Forenede Stater, 48341
    - 21st Century Oncology-Pontiac
  - Pontiac, Michigan, Forenede Stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Newland Medical Associates-Pontiac
  - Port Huron, Michigan, Forenede Stater, 48060
    - Lake Huron Medical Center
  - Reed City, Michigan, Forenede Stater, 49677
    - Spectrum Health Reed City Hospital
  - Rochester Hills, Michigan, Forenede Stater, 48309
    - Great Lakes Cancer Management Specialists-Rochester Hills
  - Roseville, Michigan, Forenede Stater, 48066
    - Michigan Cancer Specialists
  - Royal Oak, Michigan, Forenede Stater, 48073
    - William Beaumont Hospital-Royal Oak
  - Royal Oak, Michigan, Forenede Stater, 48067
    - Oakland Colon and Rectal Association
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Cancer Care Associates PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Comprehensive Medical Center PLLC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Hematology Oncology Consultants PC
  - Royal Oak, Michigan, Forenede Stater, 48073
    - Oakland Medical Group
  - Saginaw, Michigan, Forenede Stater, 48601
    - Saint Mary's of Michigan
  - Saginaw, Michigan, Forenede Stater, 48604
    - Oncology Hematology Associates of Saginaw Valley PC
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Hospital
  - Southfield, Michigan, Forenede Stater, 48075
    - Providence Hospital-Southfield Cancer Center
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Premier Hematology Oncology Care
  - Sterling Heights, Michigan, Forenede Stater, 48314
    - Mitchell Folbe MD PC
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Troy, Michigan, Forenede Stater, 48098
    - William Beaumont Hospital - Troy
  - Troy, Michigan, Forenede Stater, 48084
    - Michigan Institute of Urology-Town Center
  - Troy, Michigan, Forenede Stater, 48085
    - Claudia BR Herke MD PC
  - Troy, Michigan, Forenede Stater, 48098
    - Hematology Oncology Consultants PC-Troy
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Warren, Michigan, Forenede Stater, 48093
    - Great Lakes Cancer Management Specialists-Macomb Professional Building
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Michigan Breast Specialists-Warren
  - West Bloomfield, Michigan, Forenede Stater, 48322
    - Henry Ford West Bloomfield Hospital
  - West Branch, Michigan, Forenede Stater, 48661
    - Saint Mary's Oncology/Hematology Associates of West Branch
  - Wyoming, Michigan, Forenede Stater, 49519
    - Metro Health Hospital
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - IHA Hematology Oncology Consultants-Ann Arbor
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Clinic North-Bemidgi
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview-Southdale Hospital
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Maple Grove Medical Center
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Forenede Stater, 39705
    - Baptist Cancer Center-Golden Triangle
  - Grenada, Mississippi, Forenede Stater, 38901
    - Boston Baskin Cancer Center-Grenada
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - Oxford, Mississippi, Forenede Stater, 38655
    - Family Cancer Center-Oxford
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital-DeSoto
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Saint Louis Cancer and Breast Institute-Ballwin
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center-Carrie J Babb Cancer Center
  - Bonne Terre, Missouri, Forenede Stater, 63628
    - Parkland Health Center-Bonne Terre
  - Branson, Missouri, Forenede Stater, 65616
    - CoxHealth Cancer Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Columbia, Missouri, Forenede Stater, 65212
    - University of Missouri - Ellis Fischel
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Medical Center-Goldschmidt Cancer Center
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital-Joplin
  - Kansas City, Missouri, Forenede Stater, 64131
    - The University of Kansas Cancer Center-South
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Center
  - Kansas City, Missouri, Forenede Stater, 64154
    - The University of Kansas Cancer Center-North
  - Lee's Summit, Missouri, Forenede Stater, 64064
    - The University of Kansas Cancer Center-Lee's Summit
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Saint John's Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Louis, Missouri, Forenede Stater, 63136
    - Christian Hospital
  - Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - Missouri Baptist Outpatient Center-Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Helena, Montana, Forenede Stater, 59601
    - Saint Peter's Community Hospital
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Kearney, Nebraska, Forenede Stater, 68845
    - Heartland Hematology and Oncology
  - Lincoln, Nebraska, Forenede Stater, 68506
    - Nebraska Hematology and Oncology
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Nebraska Cancer Research Center
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Southeast Nebraska Cancer Center
  - Norfolk, Nebraska, Forenede Stater, 68701
    - Faith Regional Medical Offices West
  - North Platte, Nebraska, Forenede Stater, 69103
    - Great Plains Regional Medical Center
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Oncology Hematology West PC
  - Omaha, Nebraska, Forenede Stater, 68122
    - Hemotology and Oncology Consultants PC
  - Omaha, Nebraska, Forenede Stater, 68124
    - Oncology Hematology West
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
  - Scottsbluff, Nebraska, Forenede Stater, 69361
    - Regional West Medical Center
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - 21st Century Oncology - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Nevada Cancer Specialists-Saint Rose
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89121
    - Cancer Therapy and Integrative Medicine
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89109
    - 21st Century Oncology
  - Las Vegas, Nevada, Forenede Stater, 89148
    - 21st Century Oncology - Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Nevada Cancer Specialists-Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89182
    - 21st Century Oncology - Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Nevada Cancer Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Nevada Cancer Specialists?Oakey
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Hooksett, New Hampshire, Forenede Stater, 03106
    - New Hampshire Oncology Hematology PA-Hooksett
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center
  - Manchester, New Hampshire, Forenede Stater, 03102
    - Norris Cotton Cancer Center-Manchester
- New Jersey
  - Brick, New Jersey, Forenede Stater, 08724
    - Ocean Medical Center
  - Holmdel, New Jersey, Forenede Stater, 07733
    - Bayshore Community Hospital
  - Manahawkin, New Jersey, Forenede Stater, 08050
    - Southern Ocean County Medical Center
  - Neptune, New Jersey, Forenede Stater, 07753
    - Jersey Shore Medical Center
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Paramus, New Jersey, Forenede Stater, 07652
    - The Valley Hospital-Luckow Pavilion
  - Red Bank, New Jersey, Forenede Stater, 07701
    - Riverview Medical Center/Booker Cancer Center
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Valley Hospital
  - Ridgewood, New Jersey, Forenede Stater, 07450
    - Neurosurgeons of New Jersey-Ridgewood
  - Westwood, New Jersey, Forenede Stater, 07675
    - Valley Health System-Hematology/Oncology
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center-Downtown
  - Albuquerque, New Mexico, Forenede Stater, 87109
    - New Mexico Oncology Hematology Consultants
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
- New York
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Bronx, New York, Forenede Stater, 10467-2490
    - Montefiore Medical Center - Moses Campus
  - Brooklyn, New York, Forenede Stater, 11203
    - State University of New York Downstate Medical Center
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Cooperstown, New York, Forenede Stater, 13326
    - Mary Imogene Bassett Hospital
  - Elmira, New York, Forenede Stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - New York, New York, Forenede Stater, 10032
    - Columbia University/Herbert Irving Cancer Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Utica, New York, Forenede Stater, 13502
    - Faxton-Saint Luke's Healthcare
- North Carolina
  - Asheboro, North Carolina, Forenede Stater, 27203
    - Randolph Hospital
  - Asheville, North Carolina, Forenede Stater, 28801
    - Cancer Care of Western North Carolina
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mission Hospital-Memorial Campus
  - Asheville, North Carolina, Forenede Stater, 28803
    - Asheville Hematology-Oncology Associates
  - Burlington, North Carolina, Forenede Stater, 27215
    - Cone Health Cancer Center at Alamance Regional
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28207
    - Oncology Specialists of Charlotte
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Southern Oncology Specialists-Charlotte
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Wayne Memorial Hospital
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Cone Health Cancer Center
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - Park Ridge Hospital Breast Health Center
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Southern Oncology Specialists-Huntersville
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Lake Norman Hematology Oncology Specialists-Huntersville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Onslow Memorial Hospital
  - Matthews, North Carolina, Forenede Stater, 28105
    - Matthews Radiation Oncology Center
  - Mebane, North Carolina, Forenede Stater, 27302
    - Cone Heath Cancer Center at Mebane
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Lake Norman Hematology Oncology Specialists-Mooresville
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hosiptal
  - Reidsville, North Carolina, Forenede Stater, 27320
    - Annie Penn Memorial Hospital
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Carolina Oncology Associates PA
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Rowan Regional Medical Center
  - Wilson, North Carolina, Forenede Stater, 27893
    - Southeastern Medical Oncology Center-Wilson
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Roger Maris Cancer Center
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Cancer Care Center
- Ohio
  - Beachwood, Ohio, Forenede Stater, 44122
    - UHHS-Chagrin Highlands Medical Center
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Canton, Ohio, Forenede Stater, 44708
    - Mercy Medical Center
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chardon, Ohio, Forenede Stater, 44024
    - Geaugra Hospital
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forenede Stater, 45219
    - University of Cincinnati/Barrett Cancer Center
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forenede Stater, 44106
    - Case Western Reserve University
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43214
    - Columbus Oncology and Hematology Associates Inc
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, Forenede Stater, 45406
    - Good Samaritan Hospital - Dayton
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physicians LLC-Samaritan North
  - Dayton, Ohio, Forenede Stater, 45415
    - Samaritan North Health Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Radiation Oncology
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Elyria, Ohio, Forenede Stater, 44035
    - Mercy Cancer Center-Elyria
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Kettering, Ohio, Forenede Stater, 45420
    - First Dayton Cancer Care
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Mansfield, Ohio, Forenede Stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Mansfield, Ohio, Forenede Stater, 44903
    - OhioHealth Mansfield Hospital
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Marion, Ohio, Forenede Stater, 43302
    - OneHealth Marion General Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Ireland Cancer Center Landerbrook Health Center
  - Mentor, Ohio, Forenede Stater, 44060
    - Lake University Ireland Cancer Center
  - Middleburg Heights, Ohio, Forenede Stater, 44130
    - Southwest General Health Center Ireland Cancer Center
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Newark Radiation Oncology
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Sandusky, Ohio, Forenede Stater, 44870
    - Ireland Cancer Center at Firelands Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Strongsville, Ohio, Forenede Stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Forenede Stater, 43560
    - Flower Hospital
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Toledo, Ohio, Forenede Stater, 43606
    - The Toledo Hospital/Toledo Children's Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC-Upper Valley
  - Wadsworth, Ohio, Forenede Stater, 44281
    - University Hospitals Sharon Health Center
  - West Chester, Ohio, Forenede Stater, 45069
    - University Pointe
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Westlake, Ohio, Forenede Stater, 44145
    - UHHS-Westlake Medical Center
  - Westlake, Ohio, Forenede Stater, 44145
    - UH-Seidman Cancer Center at Saint John Medical Center
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
  - Tulsa, Oklahoma, Forenede Stater, 74146
    - Oklahoma Cancer Specialists and Research Institute-Tulsa
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Medical Center-Baker City
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Oncology and Hematology Care Southeast
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Medical Center-Ontario
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Portland, Oregon, Forenede Stater, 97239
    - SWOG
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Community Hospital
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - Cherry Tree Cancer Center
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Jefferson Hills, Pennsylvania, Forenede Stater, 15025
    - Jefferson Hospital
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Kittanning, Pennsylvania, Forenede Stater, 16201
    - Armstrong Center for Medicine and Health
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - Forbes Hospital
  - Moon, Pennsylvania, Forenede Stater, 15108
    - UPMC-Coraopolis/Heritage Valley Radiation Oncology
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - Allegheny Valley Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - UPMC-Shadyside Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Presbyterian Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pottstown, Pennsylvania, Forenede Stater, 19464
    - Pottstown Memorial Medical Center
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Medical Oncology-Pottsville
  - Reading, Pennsylvania, Forenede Stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Selinsgrove, Pennsylvania, Forenede Stater, 17870
    - Geisinger Medical Oncology-Selinsgrove
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Washington Hospital Radiation Oncology
  - Wexford, Pennsylvania, Forenede Stater, 15090
    - Wexford Health and Wellness Pavilion
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17701
    - UPMC Susquehanna
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Charleston, South Carolina, Forenede Stater, 29401
    - Roper Hospital
  - Charleston, South Carolina, Forenede Stater, 29403
    - Charleston Hematology Oncology Associates-Roper
  - Charleston, South Carolina, Forenede Stater, 29406
    - Lowcountry Hematology Oncology PA-North Charleston
  - Charleston, South Carolina, Forenede Stater, 29414
    - Bon Secours Saint Francis Hospital
  - Charleston, South Carolina, Forenede Stater, 29414
    - Charleston Hematology Oncology Associates PA-St. Francis
  - Charleston, South Carolina, Forenede Stater, 29414
    - Lowcountry Hematology Oncology PA-West Ashley
  - Easley, South Carolina, Forenede Stater, 29640
    - Greenville Health System Cancer Institute-Easley
  - Gaffney, South Carolina, Forenede Stater, 29341
    - Gibbs Cancer Center-Gaffney
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Georgetown Hospital System
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Faris
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29615
    - Greenville Health System Cancer Institute-Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Greenville Health System Cancer Institute-Butternut
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Mount Pleasant, South Carolina, Forenede Stater, 29464
    - Lowcountry Hematology Oncology PA-Mount Pleasant
  - Seneca, South Carolina, Forenede Stater, 29672
    - Greenville Health System Cancer Institute-Seneca
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
  - Spartanburg, South Carolina, Forenede Stater, 29307
    - Greenville Health System Cancer Institute-Spartanburg
  - Union, South Carolina, Forenede Stater, 29379
    - MGC Hematology Oncology-Union
  - West Columbia, South Carolina, Forenede Stater, 29169
    - Lexington Medical Center
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Rapid City Regional Hospital
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center-Oncology Clinic
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37404
    - Memorial Hospital
  - Cookeville, Tennessee, Forenede Stater, 38501
    - Cookeville Regional Medical Center
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Hixson, Tennessee, Forenede Stater, 37343
    - Pulmonary Medicine Center of Chattanooga-Hixson
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital for Women
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
  - Nashville, Tennessee, Forenede Stater, 37208
    - Meharry Medical College
  - Ooltewah, Tennessee, Forenede Stater, 37363
    - Memorial GYN Plus
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Houston, Texas, Forenede Stater, 77030
    - M D Anderson Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - The Methodist Hospital System
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Lubbock, Texas, Forenede Stater, 79410
    - Covenant Medical Center-Lakeside
  - San Antonio, Texas, Forenede Stater, 78229
    - University of Texas Health Science Center at San Antonio
- Utah
  - American Fork, Utah, Forenede Stater, 84003
    - American Fork Hospital / Huntsman Intermountain Cancer Center
  - Cedar City, Utah, Forenede Stater, 84720
    - Sandra L Maxwell Cancer Center
  - Logan, Utah, Forenede Stater, 84321
    - Logan Regional Hospital
  - Murray, Utah, Forenede Stater, 84107
    - Intermountain Medical Center
  - Ogden, Utah, Forenede Stater, 84403
    - McKay-Dee Hospital Center
  - Provo, Utah, Forenede Stater, 84604
    - Utah Valley Regional Medical Center
  - Riverton, Utah, Forenede Stater, 84065
    - Riverton Hospital
  - Saint George, Utah, Forenede Stater, 84770
    - Dixie Medical Center Regional Cancer Center
  - Salt Lake City, Utah, Forenede Stater, 84106
    - Utah Cancer Specialists-Salt Lake City
  - Salt Lake City, Utah, Forenede Stater, 84143
    - LDS Hospital
- Vermont
  - Berlin, Vermont, Forenede Stater, 05602
    - Central Vermont Medical Center/National Life Cancer Treatment
  - Burlington, Vermont, Forenede Stater, 05401
    - University of Vermont Medical Center
  - Burlington, Vermont, Forenede Stater, 05405
    - University of Vermont College of Medicine
- Virginia
  - Burke, Virginia, Forenede Stater, 22015
    - Kaiser Permanente-Burke Medical Center
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Fredericksburg, Virginia, Forenede Stater, 22408
    - Hematology Oncology Associates of Fredericksburg Inc
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Lynchburg Hematology-Oncology Clinic
  - Martinsville, Virginia, Forenede Stater, 24115
    - Memorial Hospital Of Martinsville
  - McLean, Virginia, Forenede Stater, 22102
    - Kaiser Permanente Tysons Corner Medical Center
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Norfolk, Virginia, Forenede Stater, 23505
    - DePaul Medical Center
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23230
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23226
    - Bon Secours Saint Mary's Hospital
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
  - Winchester, Virginia, Forenede Stater, 22601
    - Shenandoah Oncology Associates PC
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Auburn, Washington, Forenede Stater, 98001
    - MultiCare Auburn Medical Center
  - Bainbridge Island, Washington, Forenede Stater, 98110
    - Virginia Mason Bainbridge Island Medical Center
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Hospital Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison Medical Center
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Medical Center-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98002
    - Virginia Mason Federal Way Medical Center
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Gig Harbor, Washington, Forenede Stater, 98332
    - Tacoma/Valley Radiation Oncology Centers-Gig Harbor
  - Gig Harbor, Washington, Forenede Stater, 98335
    - MultiCare Gig Harbor Medical Park
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Kennewick, Washington, Forenede Stater, 99336
    - Northwest Cancer Clinic
  - Kirkland, Washington, Forenede Stater, 98034
    - Seattle Cancer Care Alliance at EvergreenHealth
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Lynnwood, Washington, Forenede Stater, 98036
    - Virginia Mason Lynnwood Medical Center
  - Mount Vernon, Washington, Forenede Stater, 98273
    - Skagit Valley Hospital Regional Cancer Care Center
  - Mount Vernon, Washington, Forenede Stater, 98274
    - Skagit Valley Hospital
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Poulsbo, Washington, Forenede Stater, 98370
    - Peninsula Cancer Center
  - Puyallup, Washington, Forenede Stater, 98372
    - MultiCare Good Samaritan Hospital
  - Puyallup, Washington, Forenede Stater, 98372
    - Tacoma/Valley Radiation Oncology Centers-Puyallup
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forenede Stater, 98109
    - Seattle Cancer Care Alliance
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center
  - Seattle, Washington, Forenede Stater, 98101
    - Virginia Mason Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98112
    - Kaiser Permanente Washington
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-4307
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98133
    - Seattle Cancer Care Alliance at Northwest Hospital
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Spokane, Washington, Forenede Stater, 99204
    - Rockwood Cancer Treatment Center-DHEC-Downtown
  - Spokane, Washington, Forenede Stater, 99202
    - Cancer Care Northwest - Spokane South
  - Spokane, Washington, Forenede Stater, 99208
    - Spokane Valley Cancer Center-Mayfair
  - Spokane, Washington, Forenede Stater, 99216
    - Cancer Care Northwest-Valley
  - Spokane, Washington, Forenede Stater, 99218
    - Cancer Care Northwest-North Spokane
  - Spokane, Washington, Forenede Stater, 99216
    - Spokane Valley Cancer Center-Mission
  - Spokane, Washington, Forenede Stater, 99218
    - Rockwood North Cancer Treatment Center
  - Spokane Valley, Washington, Forenede Stater, 99216
    - Rockwood Clinic Cancer Treatment Center-Valley
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Tacoma General Hospital
  - Tacoma, Washington, Forenede Stater, 98405
    - Tacoma/Valley Radiation Oncology Centers-Saint Joe's
  - Tacoma, Washington, Forenede Stater, 97405
    - Tacoma/Valley Radiation Oncology Centers-Jackson Hall
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Wenatchee, Washington, Forenede Stater, 98801
    - Wenatchee Valley Hospital and Clinics
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston
  - Huntington, West Virginia, Forenede Stater, 25702
    - Saint Mary's Medical Center
  - Martinsburg, West Virginia, Forenede Stater, 25401
    - WVUH-East City Hospital
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden-Clark Memorial Hospital
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center at Sacred Heart
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Clinic Cancer Center - Eau Claire
  - Fond Du Lac, Wisconsin, Forenede Stater, 54937
    - Aurora Health Center-Fond du Lac
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Janesville, Wisconsin, Forenede Stater, 53547
    - Mercy Health System
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Ladysmith, Wisconsin, Forenede Stater, 54848
    - Marshfield Clinic - Ladysmith Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Hospital and Clinics
  - Manitowoc, Wisconsin, Forenede Stater, 54221
    - Holy Family Memorial Hospital
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Vince Lombardi Cancer Clinic-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Saint Joseph's Hospital
  - Menomonee Falls, Wisconsin, Forenede Stater, 53051
    - Community Memorial Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Froedtert and the Medical College of Wisconsin
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Green Bay Oncology - Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Lakeview Medical Center-Marshfield Clinic
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Clinic-Rice Lake Center
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - HSHS Saint Nicholas Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Clinic Stevens Point Center
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - West Bend, Wisconsin, Forenede Stater, 53095
    - The Alyce and Elmore Kraemer Cancer Care Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Diagnostic and Treatment Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic - Weston Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Saint Clare's Hospital
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus UW Cancer Center
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

Barn
Voksen
Ældre voksen

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Patienter skal have fået tildelt S1400F
Patienterne skal have udviklet sig under eller efter forudgående platinbaseret kemoterapi; patienter, hvis eneste tidligere platin-baserede kemoterapi-regime var for stadium I-III sygdom (dvs. patienten ikke har modtaget platinbaseret kemoterapi for stadium IV eller tilbagevendende sygdom), sygdomsprogression på platinbaseret kemoterapi skal være sket inden for et år fra den sidste dato, hvor patienten modtog denne behandling; patienter skal have oplevet sygdomsprogression under eller efter tidligere anti-PD-1 eller anti-PD-L1 antistof monoterapi som deres seneste behandlingslinje; tidligere PD-1/PD-L1 kombinationsbehandling er ikke tilladt
Tidligere eksponering for CTLA-4-hæmmere (ipilimumab og tremelimumab) er ikke tilladt; forudgående eksponering for følgende er tilladt: svækkede vacciner, anti-EGFR-midler og granulocyt-makrofag kolonistimulerende faktor (GM-CSF)
Patienter må ikke have modtaget nitrosoureas eller mitomycin-C inden for 42 dage før registrering af delstudiet
Patienter må ikke have nogen tidligere dokumenteret autoimmun eller inflammatorisk sygdom (herunder inflammatorisk tarmsygdom, divertikulitis med undtagelse af divertikulose, cøliaki, irritabel tarmsygdom; Wegners syndrom; Hashimoto syndrom) inden for 3 år før registrering af delstudiet; patienter med vitiligo, immunmedieret alopeci, Graves sygdom eller psoriasis, der kræver systemisk behandling inden for de seneste 2 år, er ikke berettigede; patienter med hypothyroidisme (f. post Hashimoto syndrom), som er stabile på hormonsubstitutionsterapi, er berettigede
Patienter må ikke have nogen historie med primær immundefekt
Patienter må ikke have modtaget immunsuppressiv medicin inden for 28 dage før registrering af delstudiet og må ikke planlægge at modtage disse lægemidler, mens de er i protokolbehandling; systemiske kortikosteroider skal stoppes mindst 24 timer før registrering af delstudiet; dog er intranasale og inhalerede kortikosteroider tilladt på ethvert tidspunkt før og under protokolbehandling
Patienter må ikke have oplevet en grad 3 eller værre immunrelateret bivirkning (irAE) (undtagen asymptomatisk ikke-bulløst/ikke-eksfoliativt udslæt) eller noget uløst irAE grad 2, og heller ikke have oplevet en toksicitet, der førte til permanent seponering af tidligere anti-PD-1 /PD-L1 immunterapi
Patienter må ikke have nogen historie med organtransplantationer, der kræver brug af immunsuppressiva
Patienter må ikke have nogen kendt allergi eller reaktion på nogen komponent i durvalumab (MEDI4736) og/eller tremelimumab formulering
Patienter må ikke have kliniske tegn eller symptomer på aktiv tuberkuloseinfektion
Patienter må ikke have modtaget en levende svækket vaccination inden for 28 dage før delstudieregistrering
Patienter må ikke have kendt humant immundefektvirus (HIV) eller en kendt positiv test for hepatitis B-virusoverfladeantigen (HBV sAg) eller hepatitis C-virus-ribonukleinsyre (HCV-antistof), der indikerer aktuel akut eller kronisk infektion; patienter med et positivt hepatitis C-antistof med en negativ viral belastning er tilladt
Patienter skal have et thyreoideastimulerende hormon (TSH) med refleksfri T3/fri T4 (hvis TSH er uden for normalområdet) og elektrokardiogram (EKG) opnået inden for 7 dage før registrering af delstudiet
Patienterne skal også tilbydes deltagelse i bankvirksomhed og i de korrelative undersøgelser for indsamling og fremtidig brug af prøver.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: N/A
Interventionel model: Enkelt gruppeopgave
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Behandling (tremelimumab, durvalumab) Patienterne får tremelimumab IV over 60 minutter på dag 1 til forløb 1-4 og durvalumab IV over 60 minutter på dag 1. Kurser gentages hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Andet: Laboratoriebiomarkøranalyse Korrelative undersøgelser Biologisk: Durvalumab Givet IV Andre navne: Imfinzi Immunoglobulin G1, Anti-(Humant Protein B7-H1) (Human Monoklonal MEDI4736 Heavy Chain), Disulfid med Human Monoklonal MEDI4736 Kappa-kæde, Dimer MEDI-4736 MEDI4736 Biologisk: Tremelimumab Givet IV Andre navne: Anti-CTLA4 humant monoklonalt antistof CP-675.206 CP-675 CP-675.206 CP-675206 ticilimumab

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Behandling (tremelimumab, durvalumab)

Patienterne får tremelimumab IV over 60 minutter på dag 1 til forløb 1-4 og durvalumab IV over 60 minutter på dag 1. Kurser gentages hver 28. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Andet: Laboratoriebiomarkøranalyse

Korrelative undersøgelser

Biologisk: Durvalumab

Givet IV

Andre navne:

Imfinzi
Immunoglobulin G1, Anti-(Humant Protein B7-H1) (Human Monoklonal MEDI4736 Heavy Chain), Disulfid med Human Monoklonal MEDI4736 Kappa-kæde, Dimer
MEDI-4736
MEDI4736

Biologisk: Tremelimumab

Givet IV

Andre navne:

Anti-CTLA4 humant monoklonalt antistof CP-675.206
CP-675
CP-675.206
CP-675206
ticilimumab

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Objektiv svarprocent Tidsramme: Fra registreringsdato til progression eller behandlingsophør, op til 2 år og 5,5 måneder.	Procentdel af deltagere med bekræftet eller ubekræftet, fuldstændig eller delvis respons på behandling med MEDI4736 (durvalumab) plus tremelimumab pr. responsevalueringskriterier i solide tumorer (RECIST 1.1). Komplet respons (CR): Fuldstændig forsvinden af alle mål- og ikke-mållæsioner. Ingen nye læsioner. Ingen sygdomsrelaterede symptomer. Eventuelle lymfeknuder (hvad enten de er mål eller ikke-mål) skal have reduktion i kort akse til < 1,0 cm. Al sygdom skal vurderes ved hjælp af samme teknik som baseline. Delvis respons (PR): Gælder kun for patienter med mindst én målbar læsion. Større end eller lig med 30 % fald under baseline af summen af passende diametre for alle målbare læsioner. Ingen entydig progression af ikke-målbar sygdom. Ingen nye læsioner. Alle målbare læsioner skal vurderes ved hjælp af de samme teknikker som baseline.	Fra registreringsdato til progression eller behandlingsophør, op til 2 år og 5,5 måneder.

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Varighed af respons (DoR) blandt patienter, der opnår en komplet respons (CR) eller delvis respons (PR) (bekræftet og ubekræftet) af RECIST 1.1. Tidsramme: Fra registreringsdato til maksimalt 2 år og 5,5 måneder eller død.	Tid fra dato for første dokumentation af respons (CR eller PR) til dato for første dokumentation af progression vurderet ved lokal gennemgang eller symptomatisk forværring eller død af enhver årsag blandt patienter, der opnår et respons. Patienter, der sidst vides at være i live uden rapport om progression, censureres på datoen for sidste sygdomsvurdering. For patienter med en manglende scanning (eller på hinanden følgende manglende scanninger), hvis efterfølgende scanning bestemmer progression, vil den forventede dato for den første manglende scanning blive brugt som progressionsdato. Progression defineres som en eller flere af følgende: 20 % stigning i summen af passende diametre af målbare læsioner i forhold til den mindste observerede sum og en absolut stigning på mindst 0,5 cm; Utvetydig progression af ikke-målbar sygdom efter den behandlende læges vurdering (forklaring skal gives); Udseende af enhver ny læsion/sted; Død som følge af sygdom uden forudgående dokumentation for progression og uden symptomatisk forværring	Fra registreringsdato til maksimalt 2 år og 5,5 måneder eller død.
Varighed af respons (DoR) pr. immunrelateret responskriterier blandt patienter, der opnår en komplet respons (CR) eller delvis respons (PR) (bekræftet og ubekræftet) af RECIST 1.1 Tidsramme: Fra registreringsdato til maksimalt 2 år og 5,5 måneder eller død	Tid fra datoen for første dokumentation af respons (CR eller PR) til datoen for første dokumentation af irRC-progression vurderet ved lokal gennemgang eller symptomatisk forværring, eller død på grund af en hvilken som helst årsag. Patienter, der sidst vides at være i live uden rapport om irRC-progression, censureres på datoen for sidste sygdomsvurdering. For patienter med en manglende scanning (eller på hinanden følgende manglende scanninger), hvis efterfølgende scanning(er) bestemmer irRC-progression, vil datoen for irRC-progression være den forventede dato for den første manglende scanning (som defineret af sygdomsvurderingsplanen) eller datoen for den første scanning, der dokumenterer potentiel irRC-progression, alt efter hvad der er tidligst.	Fra registreringsdato til maksimalt 2 år og 5,5 måneder eller død
Samlet overlevelse (OS) blandt patienter behandlet med MEDI4736 (Durvalumab) plus tremelimumab Tidsramme: Dato for registrering til højst 2 år og 5,5 måneder eller død.	Tid fra datoen for delstudieregistrering til datoen for dødsfald på grund af enhver årsag. Patienter, der sidst vides at være i live, censureres på datoen for sidste kontakt.	Dato for registrering til højst 2 år og 5,5 måneder eller død.
Investigator-vurderet progressionsfri overlevelse (IA-PFS) blandt patienter behandlet med MEDI4736 (Durvalumab) plus tremelimumab. Tidsramme: Fra registreringsdato til maksimalt 2 år og 5,5 måneder eller død.	Tid fra datoen for delstudieregistrering til datoen for første dokumentation for progression vurderet ved lokal gennemgang eller symptomatisk forværring eller død på grund af en hvilken som helst årsag. Patienter, der sidst vides at være i live uden rapport om progression, censureres på datoen for sidste sygdomsvurdering. For patienter med en manglende scanning (eller på hinanden følgende manglende scanninger), hvis efterfølgende scanning bestemmer progression, blev den forventede dato for den første manglende scanning (som defineret af sygdomsvurderingsplanen) brugt som dato for progression. Progression defineres som en eller flere af følgende: 20 % stigning i summen af passende diametre af målbare læsioner i forhold til den mindste observerede sum og en absolut stigning på mindst 0,5 cm; Utvetydig progression af ikke-målbar sygdom efter den behandlende læges mening (en forklaring skal gives); Udseende af enhver ny læsion/sted; Død som følge af sygdom uden forudgående dokumentation for progression og uden symptomatisk forværring.	Fra registreringsdato til maksimalt 2 år og 5,5 måneder eller død.
Investigator-vurderet progressionsfri overlevelse (IA-PFS) vurderet ud fra immunrelaterede responskriterier (irRC-IA-PFS) blandt patienter behandlet med MEDI4736 (Durvalumab) plus tremelimumab Tidsramme: Dato for registrering til højst 2 år og 5,5 måneder eller død	Tid fra datoen for delstudieregistrering til datoen for første dokumentation for progression vurderet ved lokal gennemgang eller symptomatisk forværring eller død på grund af en hvilken som helst årsag. Patienter, der sidst vides at være i live uden rapport om progression, censureres på datoen for sidste sygdomsvurdering. For patienter med en manglende scanning (eller på hinanden følgende manglende scanninger), hvis efterfølgende scanning bestemmer progression, vil den forventede dato for den første manglende scanning (som defineret af sygdomsvurderingsplanen) blive brugt som dato for progression. irRC-progression er defineret ved progression pr. RECIST 1.1, bortset fra at progression bestemt af fremkomsten af nye læsioner eller ved en 20 % stigning i summen af diametre skal bekræftes ved en anden på hinanden følgende bestemmelse af progression mindst 28 dage fra datoen for den første dokumentation af progression.	Dato for registrering til højst 2 år og 5,5 måneder eller død
Antal deltagere med gr 3 til 5 uønskede hændelser, der er relateret til undersøgelsesstoffer Tidsramme: Behandlingsvarighed og opfølgning indtil død eller 2 år og 5,5 måneder efter registrering	Kun uønskede hændelser, der muligvis, sandsynligvis eller helt sikkert er relateret til undersøgelseslægemidlet, er rapporteret. CTCAE Version 4.0 blev brugt til rutinemæssig toksicitetsrapportering og CTCAE Version 5.0 blev brugt til rapportering af alvorlige bivirkninger (SAE).	Behandlingsvarighed og opfølgning indtil død eller 2 år og 5,5 måneder efter registrering

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

SWOG Cancer Research Network

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Ledende efterforsker: Vassiliki Papadimitrakopoulou, SWOG Cancer Research Network

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Leighl NB, Redman MW, Rizvi N, Hirsch FR, Mack PC, Schwartz LH, Wade JL, Irvin WJ, Reddy SC, Crawford J, Bradley JD, Stinchcombe TE, Ramalingam SS, Miao J, Minichiello K, Herbst RS, Papadimitrakopoulou VA, Kelly K, Gandara DR. Phase II study of durvalumab plus tremelimumab as therapy for patients with previously treated anti-PD-1/PD-L1 resistant stage IV squamous cell lung cancer (Lung-MAP substudy S1400F, NCT03373760). J Immunother Cancer. 2021 Aug;9(8):e002973. doi: 10.1136/jitc-2021-002973.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

30. november 2017

Primær færdiggørelse (Faktiske)

18. maj 2020

Studieafslutning (Faktiske)

29. marts 2022

Datoer for studieregistrering

Først indsendt

11. december 2017

Først indsendt, der opfyldte QC-kriterier

11. december 2017

Først opslået (Faktiske)

14. december 2017

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

9. juni 2023

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

7. juni 2023

Sidst verificeret

1. juni 2023

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

S1400F (Anden identifikator: CTEP)
U10CA180888 (U.S. NIH-bevilling/kontrakt)
NCI-2016-01597 (Registry Identifier: CTRP (Clinical Trial Reporting Program))

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Tilbagevendende planocellulært lungekarcinom

AHS Cancer Control Alberta
Cross Cancer Institute

Afsluttet

Fase II-forsøg med konsoliderende thoraxstrålebehandling for småcellet lungekræft i omfattende stadier

Omfattende Stage Small Cel Lung Cancer

Canada
Mayo Clinic

Rekruttering

Decitabine i kombination med standard for plejeterapi til behandling af kirurgisk resekterbar HPV-negativ hoved- og halskræft

Resecerbart hoved- og halspladecellekarcinom | HPV-negativt planocellulært karcinom | Resecerbart hoved- og nakkepladecellekarcinom | Human papillomavirus-negativ nakkepladecellekarcinom | Resektabel human papillomavirus-uafhængig hoved- og halsslimhinde Squamous Cell Carcinoma

Forenede Stater
Prof. Dr. Remi A. Nout
Merck Sharp & Dohme LLC

Ikke rekrutterer endnu

Pembrolizumab og Lenvatinib hos patienter med højrisiko lokalavanceret livmoderhalskræft

Livmoderhalskræft af FIGO Stage 2018 | Pladecellecarcinom FIGO 2018 Stadium IIIA, IIIB, IIIC1-IIIC2 | Adenocarcinoma eller Adeno-squamous Carcinoma Stadium IB3-IIIC2

Holland
Zelluna Immunotherapy AS

Rekruttering

A Study to Test the Safety, Tolerability and Effect of ZI-MA4-1 for Patients With Locally Advanced or Metastatic Solid Malignancies

Hoved- og halskræft | Livmoderhalskræft | Synoviale sarkomer | Squamous Non-Small Cell Lung Cancer (NSCLC)

Det Forenede Kongerige
Taichung Veterans General Hospital

Afsluttet

Kræftterapi-relateret kardial dysfunktion forbundet med EGFR-TKI'er i fremskreden EGFR-muteret ikke-småcellet lungekræft

Kardiotoksicitet | Non-Small Cell Lungecancer (MeSH Term: Carcinoma, Non-Small-Cell Lung) | Lægemiddelrelaterede bivirkninger og uønskede reaktioner (MeSH-betegnelse) | Egfr Tyrosinkinasehæmmer

Taiwan
Fondazione del Piemonte per l'Oncologia

Rekruttering

En undersøgelse af biologiske, genetiske og konstitutionelle faktorer samt ikke-invasiv overvågning til vurdering af personlige kræftrisici (PRO-ACTIVE)

Brystkræft | Livmoderhalskræft | Colo-rektal cancer | Melanom (hudkræft) | Non-Small Cell Lungecancer (MeSH Term: Carcinoma, Non-Small-Cell Lung)

Italien
National Cancer Institute (NCI)

Afsluttet

Navitoclax og Vistusertib til behandling af patienter med recidiverende småcellet lungekræft og andre solide tumorer

Ildfast malignt fast neoplasma | Tilbagevendende malignt fast neoplasma | Metastatisk malignt fast neoplasma | Uoprettelig fast neoplasma | Tilbagevendende småcellet lungekarcinom | Stadie IIIA Lunge småcellet karcinom AJCC v7 | Stadie IIIB Lunge småcellet karcinom AJCC v7 | Stadie IV lunge småcellet... og andre forhold

Forenede Stater
ITM Oncologics GmbH

Rekruttering

En undersøgelse til vurdering af sikkerhed, tolerabilitet og billeddannelseskarakteristika for [68Ga]Ga-DPI-4452 og til vurdering af sikkerhed, tolerabilitet og effektivitet af [177Lu]Lu-DPI-4452 hos deltagere med ikke-operable lokalt avancerede eller metastatiske faste tumorer

Tredobbelt negativ brystkræft (TNBC) | Pancreas Ductal Adenocarcinom (PDAC) | Kolorektal cancer (CRC) | Clear Cell Renal Cell Cancer (ccRCC) | Urotelcarcinom (UC) | Ubestemt nyremasse (IDRM) | Muskelinvasiv blærekræft (MIBC) | Hoved- og halskræft (H&N) | Squamous Non-Small Cell Lung Cancer (NSCLC)

Frankrig, Australien

Kliniske forsøg med Laboratoriebiomarkøranalyse

Centre Médico-Chirurgical de Réadaptation des Massues...

Rekruttering

Karakterisering af synsopfattelsesforstyrrelser hos patienter med idiopatisk skoliose (EYAIS)

Idiopatisk skoliose

Frankrig
Liao Jian An

Rekruttering

Meridianenergiændringer hos patienter med hoved- og nakkekræft efter kemoterapi eller strålebehandling

Hoved- og halskræft

Taiwan
Progenity, Inc.

Afsluttet

Udvidet ikke-invasiv genomisk medicinsk vurdering: Enigma-undersøgelsen

Downs syndrom | Aneuploidi | DiGeorges syndrom | Turners syndrom | Klinefelters syndrom | Kromosom sletning | Edwards syndrom | Patau syndrom

Forenede Stater
Nantes University Hospital

Ikke rekrutterer endnu

Reproducerbarhed af dental bidmærkeoverlayanalyse ved hjælp af digitale 3D-modeller hos voksne deltagere (OVERLAY-REPRO)

Rettsmedicinsk Tandlægevidenskab | Bidanalyse
Fondation Lenval

Trukket tilbage

Indflydelse af træthed på gangmønsteret hos patienter med cerebral parese.

Cerebral Parese

Frankrig
IRCCS Eugenio Medea

Afsluttet

Biomarkørers baner for tidlig intervention hos søskende til børn med autismespektrumforstyrrelse

Autismespektrumforstyrrelse | Tidlig indsats

Italien
Oregon Health and Science University
4DMedical

Tilmelding efter invitation

Ventilationsubalancer ved let til moderat kronisk obstruktiv lungesygdom (VAPOR)

Lungesygdomme | KOL | Luftvejssygdom | Dyspnø

Forenede Stater
IRCCS Eugenio Medea

Rekruttering

Bekræft præstationen i klinisk praksis af den fordybende Virtual Reality Platform GRAIL (Gait Real-time Analysis Interactive Lab)

Cerebral Parese | Erhvervet hjerneskade

Italien
Modarres Hospital

Afsluttet

Renal parenkymal kernenålbiopsi

Komplikationer | Billedstyret biopsi | Nyre Glomerulus

Iran, Islamisk Republik
Healthy.io Ltd.

Afsluttet

[Prøvning af enhed, der ikke er godkendt eller godkendt af U.S. FDA]

Albuminuri

Forenede Stater

Durvalumab og Tremelimumab til behandling af patienter med tilbagevendende fase IV lungekræft

Et fase II-studie af MEDI4736 (Durvalumab) Plus Tremelimumab som terapi til patienter med tidligere behandlet anti-PD-1/PD-L1-resistent trin IV planocellulært lungekræft (Lung-Map Non-Match Sub-Studie)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Kliniske forsøg med Tilbagevendende planocellulært lungekarcinom

Kliniske forsøg med Laboratoriebiomarkøranalyse

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Ukraine

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer