Afprøvning af tilsætning af et antistof til standard kemoradiation efterfulgt af antistoffet i et år til standard kemoradiation efterfulgt af et år af antistoffet hos patienter med ikke-småcellet lungecancer, som ikke kan optages i trin III
12. april 2024 opdateret af: National Cancer Institute (NCI)
Randomiseret fase III-forsøg med MEDI4736 (Durvalumab) som samtidig og konsolidativ terapi eller konsolidativ terapi alene for ikke-operabel trin 3 NSCLC
Dette fase III-forsøg undersøger, hvor godt et antistof (durvalumab) med kemoterapi og strålebehandling (kemoradiation) virker ved behandling af patienter med fase III ikke-småcellet lungekræft, som ikke kan fjernes ved kirurgi (ikke-operable).
Immunterapi med monoklonale antistoffer, såsom durvalumab, kan hjælpe kroppens immunsystem til at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig.
Denne undersøgelse udføres for at se, om tilføjelse af durvalumab til standard kemoradiation efterfulgt af yderligere durvalumab kan forlænge patientens levetid og/eller forhindre tumoren i at komme tilbage sammenlignet med den sædvanlige tilgang med kemoradiation alene efterfulgt af durvalumab.
Studieoversigt
Status
Aktiv, ikke rekrutterende
Betingelser
Intervention / Behandling
Detaljeret beskrivelse
PRIMÆR MÅL:
I. At evaluere, om der er en forbedring i den samlede overlevelse med samtidig kemoterapi/strålebehandling/MEDI4736 (durvalumab) efterfulgt af et år (12 cyklusser) med MEDI4736 (durvalumab) sammenlignet med samtidig kemoterapi/strålebehandling efterfulgt af et år (12 cyklusser) ) af MEDI4736 (durvalumab).
SEKUNDÆRE MÅL:
I. For at evaluere forskellen i respons ved hjælp af responsevalueringskriterier i solide tumorer (RECIST) 1.1 kriterier for at vurdere, hvorvidt MEDI4736 (durvalumab) tilføjet til samtidig kemo/stråling resulterer i en forbedring i responsrater.
II. For at evaluere enhver forskel i progressionsfri overlevelse (PFS) med samtidig kemoterapi/strålebehandling/MEDI4736 (durvalumab) efterfulgt af et år (12 cyklusser) MEDI4736 (durvalumab) sammenlignet med samtidig kemoterapi/strålebehandling efterfulgt af et år med MEDI4736 (durvalumab) ).
III. At evaluere om forekomsten af recidiv og recidivmønster påvirkes ved at give MEDI4736 (durvalumab) under kemo/stråling.
IV. For at evaluere enhver forskel i toksicitet, når MEDI4736 (durvalumab) tilsættes til samtidig kemo/stråling ved brug af de fælles terminologikriterier for bivirkninger (CTCAE).
OMRIDS:
TRIN 1 (SAMTIDIGT BEHANDLING): Patienterne randomiseres til 1 ud af 2 arme.
ARM A: Patienterne får durvalumab intravenøst (IV) over 60 minutter på dag 1 og 15 i cyklus 1 og dag 1 i cyklus 2. Patienterne modtager også 1 ud af 3 behandlingsregimer pr. investigatorvalg: 1) etoposid IV over 60 minutter på dag 1 -5 og cisplatin IV over 60 minutter på dag 1 og 8 hver 28. dag i 2 cyklusser; 2) pemetrexed dinatrium IV over 60 minutter og cisplatin IV over 60-120 minutter på dag 1 hver 21. dag i 2 cyklusser; eller 3) paclitaxel IV over 60 minutter og carboplatin IV over 30 minutter på dag 1 hver 7. dag i 6 cyklusser. Behandlingen fortsætter i fravær af sygdomsprogression eller uacceptabel toksicitet. Fra dag 1 af kemoterapi modtager patienter strålebehandling 5 dage om ugen i 6 uger.
ARM B: Patienterne modtager 1 ud af 3 investigators valgbehandlingsregimer og strålebehandling som i arm A.
TRIN 2 (KONSOLIDERINGSBEHANDLING): Inden for 14 dage efter den sidste stråledosis (fra trin 1) får alle patienter derefter durvalumab IV over 60 minutter på dag 1. Behandlingen gentages hver 28. dag i 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.
Efter afslutning af studiebehandlingen følges patienterne op hver 3. måned hvis mindre end 2 år fra studiestart, hver 6. måned hvis 2-5 år fra studiestart og derefter årligt i år 5-10 fra studiestart.
Undersøgelsestype
Interventionel
Tilmelding (Anslået)
660
Fase
- Fase 3
Kontakter og lokationer
Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.
Studiesteder
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Alaska
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Anchorage, Alaska, Forenede Stater, 98508
- Anchorage Associates in Radiation Medicine
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Breast Care and Surgery LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Oncology and Hematology LLC
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Anchorage, Alaska, Forenede Stater, 99508
- Alaska Women's Cancer Care
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Anchorage, Alaska, Forenede Stater, 99508
- Anchorage Oncology Centre
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Anchorage, Alaska, Forenede Stater, 99508
- Katmai Oncology Group
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Anchorage, Alaska, Forenede Stater, 99508
- Providence Alaska Medical Center
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Anchorage, Alaska, Forenede Stater, 99504
- Anchorage Radiation Therapy Center
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Fairbanks, Alaska, Forenede Stater, 99701
- Fairbanks Memorial Hospital
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Arizona
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Gilbert, Arizona, Forenede Stater, 85234
- Banner MD Anderson Cancer Center
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Kingman, Arizona, Forenede Stater, 86401
- Kingman Regional Medical Center
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Phoenix, Arizona, Forenede Stater, 85004
- Cancer Center at Saint Joseph's
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Sun City, Arizona, Forenede Stater, 85351
- Banner Boswell Medical Center
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Tucson, Arizona, Forenede Stater, 85704
- University of Arizona Cancer Center-Orange Grove Campus
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Tucson, Arizona, Forenede Stater, 85719
- Banner University Medical Center - Tucson
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Tucson, Arizona, Forenede Stater, 85719
- University of Arizona Cancer Center-North Campus
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Yuma, Arizona, Forenede Stater, 85364
- Yuma Regional Medical Center
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Arkansas
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Fort Smith, Arkansas, Forenede Stater, 72903
- Mercy Hospital Fort Smith
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Hot Springs, Arkansas, Forenede Stater, 71913
- CHI Saint Vincent Cancer Center Hot Springs
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Jonesboro, Arkansas, Forenede Stater, 72401
- NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
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Little Rock, Arkansas, Forenede Stater, 72205
- University of Arkansas for Medical Sciences
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Little Rock, Arkansas, Forenede Stater, 72205
- CARTI Cancer Center
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California
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Arroyo Grande, California, Forenede Stater, 93420
- PCR Oncology
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Arroyo Grande, California, Forenede Stater, 93420
- Mission Hope Medical Oncology - Arroyo Grande
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Auburn, California, Forenede Stater, 95602
- Sutter Auburn Faith Hospital
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Auburn, California, Forenede Stater, 95603
- Sutter Cancer Centers Radiation Oncology Services-Auburn
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Berkeley, California, Forenede Stater, 94704
- Alta Bates Summit Medical Center-Herrick Campus
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Burbank, California, Forenede Stater, 91505
- Providence Saint Joseph Medical Center/Disney Family Cancer Center
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Burlingame, California, Forenede Stater, 94010
- Mills-Peninsula Medical Center
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Cameron Park, California, Forenede Stater, 95682
- Sutter Cancer Centers Radiation Oncology Services-Cameron Park
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Carmichael, California, Forenede Stater, 95608
- Mercy San Juan Medical Center
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Carmichael, California, Forenede Stater, 95608
- Mercy Cancer Center - Carmichael
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Castro Valley, California, Forenede Stater, 94546
- Eden Hospital Medical Center
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Davis, California, Forenede Stater, 95616
- Sutter Davis Hospital
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El Segundo, California, Forenede Stater, 90245
- 21st Century Oncology - El Segundo
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Elk Grove, California, Forenede Stater, 95758
- Mercy Cancer Center - Elk Grove
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Fremont, California, Forenede Stater, 94538
- Palo Alto Medical Foundation-Fremont
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Marysville, California, Forenede Stater, 95901
- Fremont - Rideout Cancer Center
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Modesto, California, Forenede Stater, 95355
- Memorial Medical Center
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Camino Division
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Mountain View, California, Forenede Stater, 94040
- Palo Alto Medical Foundation-Gynecologic Oncology
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Novato, California, Forenede Stater, 94945
- Sutter Cancer Research Consortium
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Palo Alto, California, Forenede Stater, 94301
- Palo Alto Medical Foundation Health Care
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Rocklin, California, Forenede Stater, 95765
- Mercy Cancer Center - Rocklin
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Roseville, California, Forenede Stater, 95661
- Sutter Cancer Centers Radiation Oncology Services-Roseville
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Roseville, California, Forenede Stater, 95661
- Sutter Roseville Medical Center
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Sacramento, California, Forenede Stater, 95816
- Sutter Medical Center Sacramento
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Sacramento, California, Forenede Stater, 95817
- University of California Davis Comprehensive Cancer Center
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Sacramento, California, Forenede Stater, 95816
- Mercy Cancer Center - Sacramento
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San Francisco, California, Forenede Stater, 94115
- California Pacific Medical Center-Pacific Campus
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San Luis Obispo, California, Forenede Stater, 93401
- Pacific Central Coast Health Center-San Luis Obispo
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Santa Cruz, California, Forenede Stater, 95065
- Palo Alto Medical Foundation-Santa Cruz
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Santa Maria, California, Forenede Stater, 93444
- Mission Hope Medical Oncology - Santa Maria
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Santa Rosa, California, Forenede Stater, 95403
- Sutter Pacific Medical Foundation
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Sunnyvale, California, Forenede Stater, 94086
- Palo Alto Medical Foundation-Sunnyvale
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Vacaville, California, Forenede Stater, 95687
- Sutter Cancer Centers Radiation Oncology Services-Vacaville
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Vallejo, California, Forenede Stater, 94589
- Sutter Solano Medical Center/Cancer Center
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Woodland, California, Forenede Stater, 95695
- Woodland Memorial Hospital
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Colorado
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Aurora, Colorado, Forenede Stater, 80012
- Rocky Mountain Cancer Centers-Aurora
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Aurora, Colorado, Forenede Stater, 80012
- The Medical Center of Aurora
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Boulder, Colorado, Forenede Stater, 80301
- Boulder Community Hospital
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Boulder, Colorado, Forenede Stater, 80303
- Boulder Community Foothills Hospital
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Boulder, Colorado, Forenede Stater, 80304
- Rocky Mountain Cancer Centers-Boulder
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Centennial, Colorado, Forenede Stater, 80112
- Rocky Mountain Cancer Centers - Centennial
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Colorado Springs, Colorado, Forenede Stater, 80907
- Penrose-Saint Francis Healthcare
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Colorado Springs, Colorado, Forenede Stater, 80907
- Rocky Mountain Cancer Centers-Penrose
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Colorado Springs, Colorado, Forenede Stater, 80923
- Saint Francis Cancer Center
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Denver, Colorado, Forenede Stater, 80210
- Porter Adventist Hospital
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Denver, Colorado, Forenede Stater, 80218
- Presbyterian - Saint Lukes Medical Center - Health One
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Denver, Colorado, Forenede Stater, 80218
- SCL Health Saint Joseph Hospital
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Denver, Colorado, Forenede Stater, 80220
- Rose Medical Center
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Denver, Colorado, Forenede Stater, 80218
- Rocky Mountain Cancer Centers-Midtown
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Denver, Colorado, Forenede Stater, 80220
- Rocky Mountain Cancer Centers-Rose
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Denver, Colorado, Forenede Stater, 80218
- Colorado Blood Cancer Institute
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Denver, Colorado, Forenede Stater, 80204
- Cancer Center of Colorado at Sloan's Lake
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Denver, Colorado, Forenede Stater, 80209
- The Women's Imaging Center
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Denver, Colorado, Forenede Stater, 80206
- National Jewish Health-Main Campus
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Denver, Colorado, Forenede Stater, 80220
- Western Surgical Care
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Durango, Colorado, Forenede Stater, 81301
- Mercy Medical Center
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Durango, Colorado, Forenede Stater, 81301
- Southwest Oncology PC
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Englewood, Colorado, Forenede Stater, 80113
- Mountain Blue Cancer Care Center - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- Swedish Medical Center
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Englewood, Colorado, Forenede Stater, 80113
- Rocky Mountain Cancer Centers - Swedish
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Englewood, Colorado, Forenede Stater, 80113
- The Melanoma and Skin Cancer Institute
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Golden, Colorado, Forenede Stater, 80401
- National Jewish Health-Western Hematology Oncology
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Grand Junction, Colorado, Forenede Stater, 81501
- Saint Mary's Hospital and Regional Medical Center
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Greeley, Colorado, Forenede Stater, 80631
- North Colorado Medical Center
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Lafayette, Colorado, Forenede Stater, 80026
- Good Samaritan Medical Center
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Lakewood, Colorado, Forenede Stater, 80228
- Saint Anthony Hospital
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Lakewood, Colorado, Forenede Stater, 80228
- Rocky Mountain Cancer Centers-Lakewood
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Littleton, Colorado, Forenede Stater, 80120
- Rocky Mountain Cancer Centers-Littleton
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Littleton, Colorado, Forenede Stater, 80122
- Littleton Adventist Hospital
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Lone Tree, Colorado, Forenede Stater, 80124
- Sky Ridge Medical Center
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Lone Tree, Colorado, Forenede Stater, 80124
- Rocky Mountain Cancer Centers-Sky Ridge
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Longmont, Colorado, Forenede Stater, 80501
- Longmont United Hospital
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Longmont, Colorado, Forenede Stater, 80501
- Rocky Mountain Cancer Centers-Longmont
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Loveland, Colorado, Forenede Stater, 80539
- McKee Medical Center
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Parker, Colorado, Forenede Stater, 80138
- Parker Adventist Hospital
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Pueblo, Colorado, Forenede Stater, 81004
- Saint Mary Corwin Medical Center
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Thornton, Colorado, Forenede Stater, 80260
- Rocky Mountain Cancer Centers-Thornton
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Thornton, Colorado, Forenede Stater, 80260
- National Jewish Health-Northern Hematology Oncology
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Wheat Ridge, Colorado, Forenede Stater, 80033
- SCL Health Lutheran Medical Center
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Delaware
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Dover, Delaware, Forenede Stater, 19901
- Bayhealth Hospital Kent Campus
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Frankford, Delaware, Forenede Stater, 19945
- Beebe South Coastal Health Campus
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Lewes, Delaware, Forenede Stater, 19958
- Beebe Medical Center
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Milford, Delaware, Forenede Stater, 19963
- Bayhealth Hospital Sussex Campus
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Newark, Delaware, Forenede Stater, 19713
- Helen F Graham Cancer Center
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Newark, Delaware, Forenede Stater, 19713
- Delaware Clinical and Laboratory Physicians PA
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Newark, Delaware, Forenede Stater, 19713
- Medical Oncology Hematology Consultants PA
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Newark, Delaware, Forenede Stater, 19718
- Christiana Care Health System-Christiana Hospital
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Rehoboth Beach, Delaware, Forenede Stater, 19971
- Beebe Health Campus
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Seaford, Delaware, Forenede Stater, 19973
- TidalHealth Nanticoke / Allen Cancer Center
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Wilmington, Delaware, Forenede Stater, 19801
- Christiana Care Health System-Wilmington Hospital
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Florida
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Aventura, Florida, Forenede Stater, 33180
- GenesisCare USA - Aventura FP
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Aventura, Florida, Forenede Stater, 33180
- GenesisCare USA - Aventura
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Boca Raton, Florida, Forenede Stater, 33428
- GenesisCare USA - Boca Raton FP02
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Boca Raton, Florida, Forenede Stater, 33431
- GenesisCare USA - Boca Ration FP06
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Fort Lauderdale, Florida, Forenede Stater, 33308
- Holy Cross Hospital
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Fort Myers, Florida, Forenede Stater, 33908
- GenesisCare USA - Gladiolus
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Key West, Florida, Forenede Stater, 33040
- GenesisCare USA - Key West
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Lakeland, Florida, Forenede Stater, 33805
- The Watson Clinic
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Lakewood Ranch, Florida, Forenede Stater, 34202
- GenesisCare USA - Lakewood Ranch
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Palm Beach Gardens, Florida, Forenede Stater, 33410
- GenesisCare USA - Palm Beach Gardens
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Plantation, Florida, Forenede Stater, 33324
- GenesisCare USA - Plantation
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Tampa, Florida, Forenede Stater, 33612
- Moffitt Cancer Center
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Tampa, Florida, Forenede Stater, 33607
- Moffitt Cancer Center-International Plaza
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Tampa, Florida, Forenede Stater, 33612
- Moffitt Cancer Center - McKinley Campus
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West Palm Beach, Florida, Forenede Stater, 33401
- Good Samaritan Medical Center
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Weston, Florida, Forenede Stater, 33331
- Cleveland Clinic-Weston
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Georgia
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Atlanta, Georgia, Forenede Stater, 30308
- Emory University Hospital Midtown
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Atlanta, Georgia, Forenede Stater, 30322
- Emory University Hospital/Winship Cancer Institute
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Savannah, Georgia, Forenede Stater, 31405
- Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Thomasville, Georgia, Forenede Stater, 31792
- Lewis Hall Singletary Oncology Center
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Hawaii
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'Aiea, Hawaii, Forenede Stater, 96701
- Pali Momi Medical Center
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'Aiea, Hawaii, Forenede Stater, 96701
- Queen's Cancer Center - Pearlridge
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'Aiea, Hawaii, Forenede Stater, 96701
- The Cancer Center of Hawaii-Pali Momi
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'Aiea, Hawaii, Forenede Stater, 96701
- Straub Pearlridge Clinic
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'Aiea, Hawaii, Forenede Stater, 96701
- Hawaii Cancer Care - Westridge
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'Ewa Beach, Hawaii, Forenede Stater, 96706
- The Queen's Medical Center - West Oahu
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- The Cancer Center of Hawaii-Liliha
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Honolulu, Hawaii, Forenede Stater, 96813
- Hawaii Cancer Care Inc - Waterfront Plaza
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Honolulu, Hawaii, Forenede Stater, 96813
- Queen's Cancer Cenrer - POB I
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Honolulu, Hawaii, Forenede Stater, 96813
- Straub Clinic and Hospital
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Honolulu, Hawaii, Forenede Stater, 96813
- University of Hawaii Cancer Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Cancer Care Inc-Liliha
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Honolulu, Hawaii, Forenede Stater, 96817
- Kuakini Medical Center
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Honolulu, Hawaii, Forenede Stater, 96817
- Queen's Cancer Center - Kuakini
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Honolulu, Hawaii, Forenede Stater, 96826
- Kapiolani Medical Center for Women and Children
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Honolulu, Hawaii, Forenede Stater, 96813
- Island Urology
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Honolulu, Hawaii, Forenede Stater, 96817
- Hawaii Diagnostic Radiology Services LLC
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Kahului, Hawaii, Forenede Stater, 96732
- Straub Medical Center - Kahului Clinic
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Kailua, Hawaii, Forenede Stater, 96734
- Castle Medical Center
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Lihue, Hawaii, Forenede Stater, 96766
- Wilcox Memorial Hospital and Kauai Medical Clinic
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Idaho
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Boise, Idaho, Forenede Stater, 83706
- Saint Alphonsus Cancer Care Center-Boise
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Boise, Idaho, Forenede Stater, 83712
- Saint Luke's Cancer Institute - Boise
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Caldwell, Idaho, Forenede Stater, 83605
- Saint Alphonsus Cancer Care Center-Caldwell
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Coeur d'Alene, Idaho, Forenede Stater, 83814
- Kootenai Health - Coeur d'Alene
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Emmett, Idaho, Forenede Stater, 83617
- Walter Knox Memorial Hospital
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Fruitland, Idaho, Forenede Stater, 83619
- Saint Luke's Cancer Institute - Fruitland
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Meridian, Idaho, Forenede Stater, 83642
- Idaho Urologic Institute-Meridian
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Meridian, Idaho, Forenede Stater, 83642
- Saint Luke's Cancer Institute - Meridian
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Nampa, Idaho, Forenede Stater, 83686
- Saint Luke's Cancer Institute - Nampa
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Nampa, Idaho, Forenede Stater, 83687
- Saint Alphonsus Cancer Care Center-Nampa
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Post Falls, Idaho, Forenede Stater, 83854
- Kootenai Clinic Cancer Services - Post Falls
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Sandpoint, Idaho, Forenede Stater, 83864
- Kootenai Cancer Clinic
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Twin Falls, Idaho, Forenede Stater, 83301
- Saint Luke's Cancer Institute - Twin Falls
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Illinois
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Alton, Illinois, Forenede Stater, 62002
- Saint Anthony's Health
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Aurora, Illinois, Forenede Stater, 60504
- Rush - Copley Medical Center
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Barrington, Illinois, Forenede Stater, 60010
- Advocate Good Shepherd Hospital
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Bloomington, Illinois, Forenede Stater, 61704
- Illinois CancerCare-Bloomington
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Bloomington, Illinois, Forenede Stater, 61701
- Saint Joseph Medical Center
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Canton, Illinois, Forenede Stater, 61520
- Illinois CancerCare-Canton
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Carbondale, Illinois, Forenede Stater, 62902
- Memorial Hospital of Carbondale
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Carterville, Illinois, Forenede Stater, 62918
- SIH Cancer Institute
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Carthage, Illinois, Forenede Stater, 62321
- Illinois CancerCare-Carthage
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Centralia, Illinois, Forenede Stater, 62801
- Centralia Oncology Clinic
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Centralia, Illinois, Forenede Stater, 62801
- Saint Mary's Hospital
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Chicago, Illinois, Forenede Stater, 60611
- Northwestern University
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Chicago, Illinois, Forenede Stater, 60612
- University of Illinois
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Chicago, Illinois, Forenede Stater, 60625
- Swedish Covenant Hospital
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Chicago, Illinois, Forenede Stater, 60657
- Advocate Illinois Masonic Medical Center
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Chicago, Illinois, Forenede Stater, 60612
- Jesse Brown Veterans Affairs Medical Center
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Crystal Lake, Illinois, Forenede Stater, 60014
- AMG Crystal Lake - Oncology
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Danville, Illinois, Forenede Stater, 61832
- Carle at The Riverfront
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DeKalb, Illinois, Forenede Stater, 60115
- Northwestern Medicine Cancer Center Kishwaukee
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Decatur, Illinois, Forenede Stater, 62526
- Decatur Memorial Hospital
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Decatur, Illinois, Forenede Stater, 62526
- Cancer Care Specialists of Illinois - Decatur
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Dixon, Illinois, Forenede Stater, 61021
- Illinois CancerCare-Dixon
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Downers Grove, Illinois, Forenede Stater, 60515
- Advocate Good Samaritan Hospital
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Effingham, Illinois, Forenede Stater, 62401
- Crossroads Cancer Center
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Effingham, Illinois, Forenede Stater, 62401
- Carle Physician Group-Effingham
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Elgin, Illinois, Forenede Stater, 60123
- Advocate Sherman Hospital
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Elk Grove Village, Illinois, Forenede Stater, 60007
- Ascension Alexian Brothers - Elk Grove Village
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Eureka, Illinois, Forenede Stater, 61530
- Illinois CancerCare-Eureka
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Evanston, Illinois, Forenede Stater, 60201
- NorthShore University HealthSystem-Evanston Hospital
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Galesburg, Illinois, Forenede Stater, 61401
- Western Illinois Cancer Treatment Center
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Galesburg, Illinois, Forenede Stater, 61401
- Illinois CancerCare-Galesburg
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Geneva, Illinois, Forenede Stater, 60134
- Northwestern Medicine Cancer Center Delnor
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Glenview, Illinois, Forenede Stater, 60026
- NorthShore University HealthSystem-Glenbrook Hospital
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Glenview, Illinois, Forenede Stater, 60026
- Northwestern Medicine Glenview Outpatient Center
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Grayslake, Illinois, Forenede Stater, 60030
- Northwestern Medicine Grayslake Outpatient Center
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Hazel Crest, Illinois, Forenede Stater, 60429
- Advocate South Suburban Hospital
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Highland Park, Illinois, Forenede Stater, 60035
- NorthShore University HealthSystem-Highland Park Hospital
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Kewanee, Illinois, Forenede Stater, 61443
- Illinois CancerCare-Kewanee Clinic
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Lake Forest, Illinois, Forenede Stater, 60045
- Northwestern Medicine Lake Forest Hospital
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Libertyville, Illinois, Forenede Stater, 60048
- Condell Memorial Hospital
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Libertyville, Illinois, Forenede Stater, 60048
- AMG Libertyville - Oncology
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Macomb, Illinois, Forenede Stater, 61455
- Illinois CancerCare-Macomb
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Mattoon, Illinois, Forenede Stater, 61938
- Carle Physician Group-Mattoon/Charleston
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Maywood, Illinois, Forenede Stater, 60153
- Loyola University Medical Center
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Moline, Illinois, Forenede Stater, 61265
- Trinity Medical Center
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Mount Vernon, Illinois, Forenede Stater, 62864
- Good Samaritan Regional Health Center
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O'Fallon, Illinois, Forenede Stater, 62269
- Cancer Care Center of O'Fallon
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Oak Lawn, Illinois, Forenede Stater, 60453-2699
- Advocate Christ Medical Center
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Oak Lawn, Illinois, Forenede Stater, 60453
- Advocate Outpatient Center - Oak Lawn
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Ottawa, Illinois, Forenede Stater, 61350
- Illinois CancerCare-Ottawa Clinic
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Palos Heights, Illinois, Forenede Stater, 60463
- Advocate High Tech Medical Park
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Park Ridge, Illinois, Forenede Stater, 60068
- Advocate Lutheran General Hospital
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Pekin, Illinois, Forenede Stater, 61554
- Illinois CancerCare-Pekin
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Pekin, Illinois, Forenede Stater, 61554
- OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
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Peoria, Illinois, Forenede Stater, 61636
- Methodist Medical Center of Illinois
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Peoria, Illinois, Forenede Stater, 61637
- OSF Saint Francis Medical Center
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Peoria, Illinois, Forenede Stater, 61615
- Illinois CancerCare-Peoria
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Peoria, Illinois, Forenede Stater, 61615
- OSF Saint Francis Radiation Oncology at Peoria Cancer Center
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Peru, Illinois, Forenede Stater, 61354
- Illinois CancerCare-Peru
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Peru, Illinois, Forenede Stater, 61354
- Valley Radiation Oncology
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Princeton, Illinois, Forenede Stater, 61356
- Illinois CancerCare-Princeton
-
Rockford, Illinois, Forenede Stater, 61114
- SwedishAmerican Regional Cancer Center/ACT
-
Silvis, Illinois, Forenede Stater, 61282
- Genesis Cancer Center - Silvis
-
Springfield, Illinois, Forenede Stater, 62781
- Memorial Medical Center
-
Springfield, Illinois, Forenede Stater, 62702
- Southern Illinois University School of Medicine
-
Springfield, Illinois, Forenede Stater, 62702
- Springfield Clinic
-
Swansea, Illinois, Forenede Stater, 62226
- Southwest Illinois Health Services LLP
-
Urbana, Illinois, Forenede Stater, 61801
- Carle Cancer Center
-
Urbana, Illinois, Forenede Stater, 61801
- The Carle Foundation Hospital
-
Warrenville, Illinois, Forenede Stater, 60555
- Northwestern Medicine Cancer Center Warrenville
-
Washington, Illinois, Forenede Stater, 61571
- Illinois CancerCare - Washington
-
Yorkville, Illinois, Forenede Stater, 60560
- Rush-Copley Healthcare Center
-
-
Indiana
-
Indianapolis, Indiana, Forenede Stater, 46219
- Community Cancer Center East
-
Indianapolis, Indiana, Forenede Stater, 46227
- Community Cancer Center South
-
Indianapolis, Indiana, Forenede Stater, 46256
- Community Cancer Center North
-
Kokomo, Indiana, Forenede Stater, 46904
- Community Howard Regional Health
-
Muncie, Indiana, Forenede Stater, 47303
- IU Health Ball Memorial Hospital
-
Richmond, Indiana, Forenede Stater, 47374
- Reid Health
-
-
Iowa
-
Carroll, Iowa, Forenede Stater, 51401
- Saint Anthony Regional Hospital
-
Cedar Rapids, Iowa, Forenede Stater, 52402
- Physicians' Clinic of Iowa PC
-
Clive, Iowa, Forenede Stater, 50325
- Mercy Cancer Center-West Lakes
-
Clive, Iowa, Forenede Stater, 50325
- Medical Oncology and Hematology Associates-West Des Moines
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Alegent Health Mercy Hospital
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Heartland Oncology and Hematology LLP
-
Council Bluffs, Iowa, Forenede Stater, 51503
- Methodist Jennie Edmundson Hospital
-
Creston, Iowa, Forenede Stater, 50801
- Greater Regional Medical Center
-
Davenport, Iowa, Forenede Stater, 52803
- Genesis Medical Center - East Campus
-
Davenport, Iowa, Forenede Stater, 52804
- Genesis Cancer Care Institute
-
Davenport, Iowa, Forenede Stater, 52807
- Iowa Cancer Specialists
-
Des Moines, Iowa, Forenede Stater, 50309
- Iowa Methodist Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mercy Medical Center - Des Moines
-
Des Moines, Iowa, Forenede Stater, 50309
- Medical Oncology and Hematology Associates-Des Moines
-
Des Moines, Iowa, Forenede Stater, 50314
- Broadlawns Medical Center
-
Des Moines, Iowa, Forenede Stater, 50314
- Mission Cancer and Blood - Laurel
-
Des Moines, Iowa, Forenede Stater, 50316
- Iowa Lutheran Hospital
-
Fort Dodge, Iowa, Forenede Stater, 50501
- Trinity Regional Medical Center
-
Sioux City, Iowa, Forenede Stater, 51101
- Siouxland Regional Cancer Center
-
West Des Moines, Iowa, Forenede Stater, 50266-7700
- Methodist West Hospital
-
West Des Moines, Iowa, Forenede Stater, 50266
- Mercy Medical Center-West Lakes
-
-
Kansas
-
Garden City, Kansas, Forenede Stater, 67846
- Central Care Cancer Center - Garden City
-
Great Bend, Kansas, Forenede Stater, 67530
- Central Care Cancer Center - Great Bend
-
Topeka, Kansas, Forenede Stater, 66606
- Cotton O'Neil Cancer Center / Stormont Vail Health
-
-
Kentucky
-
Bardstown, Kentucky, Forenede Stater, 40004
- Flaget Memorial Hospital
-
Corbin, Kentucky, Forenede Stater, 40701
- Commonwealth Cancer Center-Corbin
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Radiation Oncology Resource Center
-
Lexington, Kentucky, Forenede Stater, 40509
- Saint Joseph Hospital East
-
Lexington, Kentucky, Forenede Stater, 40504
- Saint Joseph Hospital
-
London, Kentucky, Forenede Stater, 40741
- Saint Joseph London
-
Louisville, Kentucky, Forenede Stater, 40202
- Jewish Hospital
-
Louisville, Kentucky, Forenede Stater, 40245
- UofL Health Medical Center Northeast
-
Louisville, Kentucky, Forenede Stater, 40215
- Saints Mary and Elizabeth Hospital
-
Mount Sterling, Kentucky, Forenede Stater, 40353
- Saint Joseph Mount Sterling
-
Paducah, Kentucky, Forenede Stater, 42003
- Mercy Health - Paducah Medical Oncology and Hematology
-
Shepherdsville, Kentucky, Forenede Stater, 40165
- Jewish Hospital Medical Center South
-
-
Louisiana
-
Baton Rouge, Louisiana, Forenede Stater, 70836
- Ochsner High Grove
-
Covington, Louisiana, Forenede Stater, 70433
- Ochsner Hematology Oncology North Shore - Covington (West Region)
-
New Orleans, Louisiana, Forenede Stater, 70121
- Ochsner Medical Center Jefferson
-
Shreveport, Louisiana, Forenede Stater, 71105
- CHRISTUS Highland Medical Center
-
-
Maine
-
Bangor, Maine, Forenede Stater, 04401
- Eastern Maine Medical Center
-
Bath, Maine, Forenede Stater, 04530
- MaineHealth Coastal Cancer Treatment Center
-
Biddeford, Maine, Forenede Stater, 04005
- MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
-
Brewer, Maine, Forenede Stater, 04412
- Lafayette Family Cancer Center-EMMC
-
Portland, Maine, Forenede Stater, 04102
- Maine Medical Center-Bramhall Campus
-
Sanford, Maine, Forenede Stater, 04073
- MaineHealth Cancer Care Center of York County
-
Sanford, Maine, Forenede Stater, 04073
- MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
-
Scarborough, Maine, Forenede Stater, 04074
- Maine Medical Center- Scarborough Campus
-
South Portland, Maine, Forenede Stater, 04106
- Maine Medical Partners - South Portland
-
-
Maryland
-
Baltimore, Maryland, Forenede Stater, 21204
- Greater Baltimore Medical Center
-
Baltimore, Maryland, Forenede Stater, 21229
- Saint Agnes Hospital
-
Bel Air, Maryland, Forenede Stater, 21014
- UM Upper Chesapeake Medical Center
-
Easton, Maryland, Forenede Stater, 21601
- University of Maryland Shore Medical Center at Easton
-
Elkton, Maryland, Forenede Stater, 21921
- Christiana Care - Union Hospital
-
-
Massachusetts
-
Beverly, Massachusetts, Forenede Stater, 01915
- Beverly Hospital
-
Boston, Massachusetts, Forenede Stater, 02118
- Boston Medical Center
-
Burlington, Massachusetts, Forenede Stater, 01805
- Lahey Hospital and Medical Center
-
Gloucester, Massachusetts, Forenede Stater, 01930
- Addison Gilbert Hospital
-
Peabody, Massachusetts, Forenede Stater, 01960
- Lahey Medical Center-Peabody
-
Plymouth, Massachusetts, Forenede Stater, 02360
- Beth Israel Deaconess Hospital-Plymouth
-
Springfield, Massachusetts, Forenede Stater, 01199
- Baystate Medical Center
-
Springfield, Massachusetts, Forenede Stater, 01104
- Mercy Medical Center
-
Winchester, Massachusetts, Forenede Stater, 01890
- Winchester Hospital
-
Worcester, Massachusetts, Forenede Stater, 01655
- UMass Memorial Medical Center - University Campus
-
-
Michigan
-
Ann Arbor, Michigan, Forenede Stater, 48106
- Saint Joseph Mercy Hospital
-
Battle Creek, Michigan, Forenede Stater, 49017
- Bronson Battle Creek
-
Brighton, Michigan, Forenede Stater, 48114
- Saint Joseph Mercy Brighton
-
Brighton, Michigan, Forenede Stater, 48114
- Trinity Health IHA Medical Group Hematology Oncology - Brighton
-
Canton, Michigan, Forenede Stater, 48188
- Saint Joseph Mercy Canton
-
Canton, Michigan, Forenede Stater, 48188
- Trinity Health IHA Medical Group Hematology Oncology - Canton
-
Caro, Michigan, Forenede Stater, 48723
- Caro Cancer Center
-
Chelsea, Michigan, Forenede Stater, 48118
- Saint Joseph Mercy Chelsea
-
Chelsea, Michigan, Forenede Stater, 48118
- Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
-
Clarkston, Michigan, Forenede Stater, 48346
- Hematology Oncology Consultants-Clarkston
-
Clarkston, Michigan, Forenede Stater, 48346
- Newland Medical Associates-Clarkston
-
Clarkston, Michigan, Forenede Stater, 48346
- Michigan Healthcare Professionals Clarkston
-
Detroit, Michigan, Forenede Stater, 48236
- Ascension Saint John Hospital
-
East China Township, Michigan, Forenede Stater, 48054
- Great Lakes Cancer Management Specialists-Doctors Park
-
Farmington Hills, Michigan, Forenede Stater, 48334
- Michigan Healthcare Professionals Farmington
-
Flint, Michigan, Forenede Stater, 48503
- Hurley Medical Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Cancer and Blood Disease Treatment Center
-
Flint, Michigan, Forenede Stater, 48503
- Genesee Hematology Oncology PC
-
Flint, Michigan, Forenede Stater, 48503
- Genesys Hurley Cancer Institute
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Spectrum Health at Butterworth Campus
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Helen DeVos Children's Hospital at Spectrum Health
-
Grand Rapids, Michigan, Forenede Stater, 49503
- Trinity Health Grand Rapids Hospital
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Academic Hematology Oncology Specialists
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
-
Grosse Pointe Woods, Michigan, Forenede Stater, 48236
- Michigan Breast Specialists-Grosse Pointe Woods
-
Kalamazoo, Michigan, Forenede Stater, 49007
- West Michigan Cancer Center
-
Kalamazoo, Michigan, Forenede Stater, 49007
- Bronson Methodist Hospital
-
Kalamazoo, Michigan, Forenede Stater, 49048
- Borgess Medical Center
-
Kalamazoo, Michigan, Forenede Stater, 49009
- Ascension Borgess Cancer Center
-
Lansing, Michigan, Forenede Stater, 48912
- University of Michigan Health - Sparrow Lansing
-
Livonia, Michigan, Forenede Stater, 48154
- Trinity Health Saint Mary Mercy Livonia Hospital
-
Livonia, Michigan, Forenede Stater, 48154
- Hope Cancer Clinic
-
Macomb, Michigan, Forenede Stater, 48044
- Great Lakes Cancer Management Specialists-Macomb Medical Campus
-
Macomb, Michigan, Forenede Stater, 48044
- Michigan Breast Specialists-Macomb Township
-
Macomb, Michigan, Forenede Stater, 48044
- Michigan Healthcare Professionals Macomb
-
Madison Heights, Michigan, Forenede Stater, 48071
- Michigan Healthcare Professionals Madison Heights
-
Marlette, Michigan, Forenede Stater, 48453
- Saint Mary's Oncology/Hematology Associates of Marlette
-
Muskegon, Michigan, Forenede Stater, 49444
- Trinity Health Muskegon Hospital
-
Niles, Michigan, Forenede Stater, 49120
- Corewell Health Lakeland Hospitals - Niles Hospital
-
Norton Shores, Michigan, Forenede Stater, 49444
- Cancer and Hematology Centers of Western Michigan - Norton Shores
-
Novi, Michigan, Forenede Stater, 48374
- Ascension Providence Hospitals - Novi
-
Pontiac, Michigan, Forenede Stater, 48341
- Saint Joseph Mercy Oakland
-
Pontiac, Michigan, Forenede Stater, 48341
- 21st Century Oncology-Pontiac
-
Pontiac, Michigan, Forenede Stater, 48341
- Hope Cancer Center
-
Pontiac, Michigan, Forenede Stater, 48341
- Newland Medical Associates-Pontiac
-
Reed City, Michigan, Forenede Stater, 49677
- Corewell Health Reed City Hospital
-
Rochester Hills, Michigan, Forenede Stater, 48309
- Great Lakes Cancer Management Specialists-Rochester Hills
-
Saginaw, Michigan, Forenede Stater, 48601
- Ascension Saint Mary's Hospital
-
Saginaw, Michigan, Forenede Stater, 48604
- Oncology Hematology Associates of Saginaw Valley PC
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Lakeland Medical Center Saint Joseph
-
Saint Joseph, Michigan, Forenede Stater, 49085
- Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
-
Southfield, Michigan, Forenede Stater, 48075
- Ascension Providence Hospitals - Southfield
-
Sterling Heights, Michigan, Forenede Stater, 48312
- Bhadresh Nayak MD PC-Sterling Heights
-
Tawas City, Michigan, Forenede Stater, 48764
- Ascension Saint Joseph Hospital
-
Traverse City, Michigan, Forenede Stater, 49684
- Munson Medical Center
-
Troy, Michigan, Forenede Stater, 48098
- GenesisCare USA - Troy
-
Warren, Michigan, Forenede Stater, 48093
- Saint John Macomb-Oakland Hospital
-
Warren, Michigan, Forenede Stater, 48088
- Advanced Breast Care Center PLLC
-
Warren, Michigan, Forenede Stater, 48093
- Great Lakes Cancer Management Specialists-Macomb Professional Building
-
Warren, Michigan, Forenede Stater, 48093
- Macomb Hematology Oncology PC
-
Warren, Michigan, Forenede Stater, 48093
- Michigan Breast Specialists-Warren
-
West Branch, Michigan, Forenede Stater, 48661
- Saint Mary's Oncology/Hematology Associates of West Branch
-
Wyoming, Michigan, Forenede Stater, 49519
- University of Michigan Health - West
-
Ypsilanti, Michigan, Forenede Stater, 48197
- Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
-
Ypsilanti, Michigan, Forenede Stater, 48106
- Huron Gastroenterology PC
-
-
Minnesota
-
Aitkin, Minnesota, Forenede Stater, 56431
- Riverwood Healthcare Center
-
Baxter, Minnesota, Forenede Stater, 56425
- Essentia Health - Baxter Clinic
-
Bemidji, Minnesota, Forenede Stater, 56601
- Sanford Joe Lueken Cancer Center
-
Brainerd, Minnesota, Forenede Stater, 56401
- Essentia Health Saint Joseph's Medical Center
-
Burnsville, Minnesota, Forenede Stater, 55337
- Fairview Ridges Hospital
-
Burnsville, Minnesota, Forenede Stater, 55337
- Minnesota Oncology - Burnsville
-
Cambridge, Minnesota, Forenede Stater, 55008
- Cambridge Medical Center
-
Coon Rapids, Minnesota, Forenede Stater, 55433
- Mercy Hospital
-
Deer River, Minnesota, Forenede Stater, 56636
- Essentia Health - Deer River Clinic
-
Detroit Lakes, Minnesota, Forenede Stater, 56501
- Essentia Health Saint Mary's - Detroit Lakes Clinic
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Cancer Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Essentia Health Saint Mary's Medical Center
-
Duluth, Minnesota, Forenede Stater, 55805
- Miller-Dwan Hospital
-
Edina, Minnesota, Forenede Stater, 55435
- Fairview Southdale Hospital
-
Ely, Minnesota, Forenede Stater, 55731
- Essentia Health - Ely Clinic
-
Fergus Falls, Minnesota, Forenede Stater, 56537
- Lake Region Healthcare Corporation-Cancer Care
-
Fosston, Minnesota, Forenede Stater, 56542
- Essentia Health - Fosston
-
Fridley, Minnesota, Forenede Stater, 55432
- Unity Hospital
-
Hibbing, Minnesota, Forenede Stater, 55746
- Essentia Health Hibbing Clinic
-
International Falls, Minnesota, Forenede Stater, 56649
- Essentia Health - International Falls Clinic
-
Maple Grove, Minnesota, Forenede Stater, 55369
- Fairview Clinics and Surgery Center Maple Grove
-
Maplewood, Minnesota, Forenede Stater, 55109
- Saint John's Hospital - Healtheast
-
Maplewood, Minnesota, Forenede Stater, 55109
- Minnesota Oncology Hematology PA-Maplewood
-
Minneapolis, Minnesota, Forenede Stater, 55415
- Hennepin County Medical Center
-
Minneapolis, Minnesota, Forenede Stater, 55407
- Abbott-Northwestern Hospital
-
Minneapolis, Minnesota, Forenede Stater, 55454
- Health Partners Inc
-
Monticello, Minnesota, Forenede Stater, 55362
- Monticello Cancer Center
-
Moose Lake, Minnesota, Forenede Stater, 55767
- Essentia Health - Moose Lake Clinic
-
New Ulm, Minnesota, Forenede Stater, 56073
- New Ulm Medical Center
-
Park Rapids, Minnesota, Forenede Stater, 56470
- Essentia Health - Park Rapids
-
Princeton, Minnesota, Forenede Stater, 55371
- Fairview Northland Medical Center
-
Robbinsdale, Minnesota, Forenede Stater, 55422
- North Memorial Medical Health Center
-
Saint Louis Park, Minnesota, Forenede Stater, 55416
- Park Nicollet Clinic - Saint Louis Park
-
Saint Paul, Minnesota, Forenede Stater, 55101
- Regions Hospital
-
Saint Paul, Minnesota, Forenede Stater, 55102
- United Hospital
-
Sandstone, Minnesota, Forenede Stater, 55072
- Essentia Health Sandstone
-
Shakopee, Minnesota, Forenede Stater, 55379
- Saint Francis Regional Medical Center
-
Stillwater, Minnesota, Forenede Stater, 55082
- Lakeview Hospital
-
Thief River Falls, Minnesota, Forenede Stater, 56701
- Sanford Thief River Falls Medical Center
-
Virginia, Minnesota, Forenede Stater, 55792
- Essentia Health Virginia Clinic
-
Waconia, Minnesota, Forenede Stater, 55387
- Ridgeview Medical Center
-
Willmar, Minnesota, Forenede Stater, 56201
- Rice Memorial Hospital
-
Woodbury, Minnesota, Forenede Stater, 55125
- Minnesota Oncology Hematology PA-Woodbury
-
Wyoming, Minnesota, Forenede Stater, 55092
- Fairview Lakes Medical Center
-
-
Mississippi
-
Columbus, Mississippi, Forenede Stater, 39705
- Baptist Memorial Hospital and Cancer Center-Golden Triangle
-
Grenada, Mississippi, Forenede Stater, 38901
- Baptist Cancer Center-Grenada
-
Hattiesburg, Mississippi, Forenede Stater, 39401
- Hattiesburg Clinic - Hematology/Oncology Clinic
-
Hattiesburg, Mississippi, Forenede Stater, 39404
- Forrest General Hospital / Cancer Center
-
Jackson, Mississippi, Forenede Stater, 39216
- University of Mississippi Medical Center
-
New Albany, Mississippi, Forenede Stater, 38652
- Baptist Memorial Hospital and Cancer Center-Union County
-
Oxford, Mississippi, Forenede Stater, 38655
- Baptist Memorial Hospital and Cancer Center-Oxford
-
Southhaven, Mississippi, Forenede Stater, 38671
- Baptist Memorial Hospital and Cancer Center-Desoto
-
-
Missouri
-
Ballwin, Missouri, Forenede Stater, 63011
- Saint Louis Cancer and Breast Institute-Ballwin
-
Bolivar, Missouri, Forenede Stater, 65613
- Central Care Cancer Center - Bolivar
-
Branson, Missouri, Forenede Stater, 65616
- Cox Cancer Center Branson
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Saint Francis Medical Center
-
Cape Girardeau, Missouri, Forenede Stater, 63703
- Southeast Cancer Center
-
Farmington, Missouri, Forenede Stater, 63640
- Parkland Health Center - Farmington
-
Jefferson City, Missouri, Forenede Stater, 65109
- Capital Region Southwest Campus
-
Joplin, Missouri, Forenede Stater, 64804
- Freeman Health System
-
Joplin, Missouri, Forenede Stater, 64804
- Mercy Hospital Joplin
-
Osage Beach, Missouri, Forenede Stater, 65065
- Lake Regional Hospital
-
Rolla, Missouri, Forenede Stater, 65401
- Delbert Day Cancer Institute at PCRMC
-
Rolla, Missouri, Forenede Stater, 65401
- Mercy Clinic-Rolla-Cancer and Hematology
-
Saint Joseph, Missouri, Forenede Stater, 64506
- Heartland Regional Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63131
- Missouri Baptist Medical Center
-
Saint Louis, Missouri, Forenede Stater, 63141
- Mercy Hospital Saint Louis
-
Saint Louis, Missouri, Forenede Stater, 63128
- Mercy Hospital South
-
Saint Louis, Missouri, Forenede Stater, 63109
- Saint Louis Cancer and Breast Institute-South City
-
Sainte Genevieve, Missouri, Forenede Stater, 63670
- Sainte Genevieve County Memorial Hospital
-
Springfield, Missouri, Forenede Stater, 65807
- CoxHealth South Hospital
-
Springfield, Missouri, Forenede Stater, 65804
- Mercy Hospital Springfield
-
Sullivan, Missouri, Forenede Stater, 63080
- Missouri Baptist Sullivan Hospital
-
Sunset Hills, Missouri, Forenede Stater, 63127
- BJC Outpatient Center at Sunset Hills
-
Washington, Missouri, Forenede Stater, 63090
- Mercy Hospital Washington
-
-
Montana
-
Anaconda, Montana, Forenede Stater, 59711
- Community Hospital of Anaconda
-
Billings, Montana, Forenede Stater, 59101
- Billings Clinic Cancer Center
-
Billings, Montana, Forenede Stater, 59101
- Saint Vincent Healthcare
-
Billings, Montana, Forenede Stater, 59102
- Saint Vincent Frontier Cancer Center
-
Bozeman, Montana, Forenede Stater, 59715
- Bozeman Deaconess Hospital
-
Butte, Montana, Forenede Stater, 59701
- Saint James Community Hospital and Cancer Treatment Center
-
Great Falls, Montana, Forenede Stater, 59405
- Great Falls Clinic
-
Great Falls, Montana, Forenede Stater, 59405
- Benefis Healthcare- Sletten Cancer Institute
-
Kalispell, Montana, Forenede Stater, 59901
- Kalispell Regional Medical Center
-
Missoula, Montana, Forenede Stater, 59804
- Community Medical Hospital
-
Missoula, Montana, Forenede Stater, 59802
- Saint Patrick Hospital - Community Hospital
-
-
Nebraska
-
Grand Island, Nebraska, Forenede Stater, 68803
- CHI Health Saint Francis
-
Kearney, Nebraska, Forenede Stater, 68847
- CHI Health Good Samaritan
-
Lincoln, Nebraska, Forenede Stater, 68516
- Southeast Nebraska Cancer Center - 68th Street Place
-
Lincoln, Nebraska, Forenede Stater, 68510
- Saint Elizabeth Regional Medical Center
-
Lincoln, Nebraska, Forenede Stater, 68516
- Cancer Partners of Nebraska - Pine Lake
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Methodist Hospital
-
Omaha, Nebraska, Forenede Stater, 68124
- Alegent Health Bergan Mercy Medical Center
-
Omaha, Nebraska, Forenede Stater, 68122
- Alegent Health Immanuel Medical Center
-
Omaha, Nebraska, Forenede Stater, 68130
- Alegent Health Lakeside Hospital
-
Omaha, Nebraska, Forenede Stater, 68131
- Creighton University Medical Center
-
Omaha, Nebraska, Forenede Stater, 68114
- Oncology Associates PC
-
Omaha, Nebraska, Forenede Stater, 68114
- Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
-
Papillion, Nebraska, Forenede Stater, 68046
- Midlands Community Hospital
-
-
Nevada
-
Carson City, Nevada, Forenede Stater, 89703
- Carson Tahoe Regional Medical Center
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- OptumCare Cancer Care at Seven Hills
-
Henderson, Nevada, Forenede Stater, 89052
- Cancer and Blood Specialists-Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Las Vegas Cancer Center-Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- Comprehensive Cancer Centers of Nevada-Southeast Henderson
-
Henderson, Nevada, Forenede Stater, 89074
- GenesisCare USA - Henderson
-
Henderson, Nevada, Forenede Stater, 89052
- Comprehensive Cancer Centers of Nevada-Horizon Ridge
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Green Valley
-
Henderson, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pebble
-
Henderson, Nevada, Forenede Stater, 89074
- Urology Specialists of Nevada - Green Valley
-
Las Vegas, Nevada, Forenede Stater, 89144
- Summerlin Hospital Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89109
- Sunrise Hospital and Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89102
- OptumCare Cancer Care at Charleston
-
Las Vegas, Nevada, Forenede Stater, 89106
- Radiation Oncology Centers of Nevada Central
-
Las Vegas, Nevada, Forenede Stater, 89109
- GenesisCare USA - Las Vegas
-
Las Vegas, Nevada, Forenede Stater, 89119
- Radiation Oncology Centers of Nevada Southeast
-
Las Vegas, Nevada, Forenede Stater, 89128
- Comprehensive Cancer Centers of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89128
- OptumCare Cancer Care at MountainView
-
Las Vegas, Nevada, Forenede Stater, 89135
- Alliance for Childhood Diseases/Cure 4 the Kids Foundation
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada - Town Center
-
Las Vegas, Nevada, Forenede Stater, 89144
- Comprehensive Cancer Centers of Nevada-Summerlin
-
Las Vegas, Nevada, Forenede Stater, 89148
- Comprehensive Cancer Centers of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89148
- OptumCare Cancer Care at Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89169
- Comprehensive Cancer Centers of Nevada - Central Valley
-
Las Vegas, Nevada, Forenede Stater, 89102
- University Medical Center of Southern Nevada
-
Las Vegas, Nevada, Forenede Stater, 89109
- HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
-
Las Vegas, Nevada, Forenede Stater, 89113
- HealthCare Partners Medical Group Oncology/Hematology-San Martin
-
Las Vegas, Nevada, Forenede Stater, 89128
- GenesisCare USA - Vegas Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89128
- HealthCare Partners Medical Group Oncology/Hematology-Tenaya
-
Las Vegas, Nevada, Forenede Stater, 89148-2405
- Las Vegas Cancer Center-Medical Center
-
Las Vegas, Nevada, Forenede Stater, 89148
- GenesisCare USA - Fort Apache
-
Las Vegas, Nevada, Forenede Stater, 89149
- HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
-
Las Vegas, Nevada, Forenede Stater, 89128
- Ann M Wierman MD LTD
-
Las Vegas, Nevada, Forenede Stater, 89074
- Las Vegas Urology - Pecos
-
Las Vegas, Nevada, Forenede Stater, 89102
- Desert West Surgery
-
Las Vegas, Nevada, Forenede Stater, 89103
- Hope Cancer Care of Nevada
-
Las Vegas, Nevada, Forenede Stater, 89106
- Urology Specialists of Nevada - Central
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Prostate Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Las Vegas Urology - Sunset
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Cathedral Rock
-
Las Vegas, Nevada, Forenede Stater, 89128
- Las Vegas Urology - Smoke Ranch
-
Las Vegas, Nevada, Forenede Stater, 89128
- Urology Specialists of Nevada - Northwest
-
Las Vegas, Nevada, Forenede Stater, 89169
- University Cancer Center
-
Las Vegas, Nevada, Forenede Stater, 89113
- Urology Specialists of Nevada - Southwest
-
Pahrump, Nevada, Forenede Stater, 89048
- Hope Cancer Care of Nevada-Pahrump
-
Reno, Nevada, Forenede Stater, 89502
- Renown Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89503
- Saint Mary's Regional Medical Center
-
Reno, Nevada, Forenede Stater, 89509
- Radiation Oncology Associates
-
-
New Hampshire
-
Concord, New Hampshire, Forenede Stater, 03301
- New Hampshire Oncology Hematology PA-Concord
-
Lebanon, New Hampshire, Forenede Stater, 03756
- Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
-
Manchester, New Hampshire, Forenede Stater, 03103
- Solinsky Center for Cancer Care
-
Manchester, New Hampshire, Forenede Stater, 03103
- Elliot Hospital
-
-
New Jersey
-
Hamilton, New Jersey, Forenede Stater, 08690
- The Cancer Institute of New Jersey Hamilton
-
Jersey City, New Jersey, Forenede Stater, 07302
- Jersey City Medical Center
-
Lakewood, New Jersey, Forenede Stater, 08701
- Monmouth Medical Center Southern Campus
-
Livingston, New Jersey, Forenede Stater, 07039
- Saint Barnabas Medical Center
-
Long Branch, New Jersey, Forenede Stater, 07740
- Monmouth Medical Center
-
Moorestown, New Jersey, Forenede Stater, 08057
- Virtua Samson Cancer Center
-
Mount Holly, New Jersey, Forenede Stater, 08060
- Virtua Memorial
-
New Brunswick, New Jersey, Forenede Stater, 08903
- Rutgers Cancer Institute of New Jersey
-
Somerville, New Jersey, Forenede Stater, 08876
- Robert Wood Johnson University Hospital Somerset
-
Toms River, New Jersey, Forenede Stater, 08755
- Community Medical Center
-
Voorhees, New Jersey, Forenede Stater, 08043
- Virtua Voorhees
-
-
New Mexico
-
Albuquerque, New Mexico, Forenede Stater, 87102
- University of New Mexico Cancer Center
-
-
New York
-
Auburn, New York, Forenede Stater, 13021
- Hematology Oncology Associates of Central New York-Auburn
-
Bronx, New York, Forenede Stater, 10468
- James J Peters VA Medical Center
-
Canandaigua, New York, Forenede Stater, 14424
- Sands Cancer Center
-
East Syracuse, New York, Forenede Stater, 13057
- Hematology Oncology Associates of Central New York-East Syracuse
-
Elmira, New York, Forenede Stater, 14905
- Arnot Ogden Medical Center/Falck Cancer Center
-
Glens Falls, New York, Forenede Stater, 12801
- Glens Falls Hospital
-
Middletown, New York, Forenede Stater, 10940
- Garnet Health Medical Center
-
Oneida, New York, Forenede Stater, 13421
- Upstate Cancer Center Radiation Oncology at Oneida
-
Oswego, New York, Forenede Stater, 13126
- Upstate Cancer Center at Oswego
-
Oswego, New York, Forenede Stater, 13126
- Upstate Cancer Center Radiation Oncology at Oswego
-
Rochester, New York, Forenede Stater, 14642
- University of Rochester
-
Rochester, New York, Forenede Stater, 14620
- Highland Hospital
-
Stony Brook, New York, Forenede Stater, 11794
- Stony Brook University Medical Center
-
Syracuse, New York, Forenede Stater, 13210
- State University of New York Upstate Medical University
-
Syracuse, New York, Forenede Stater, 13215
- Hematology Oncology Associates of Central New York-Onondaga Hill
-
Syracuse, New York, Forenede Stater, 13210
- Upstate Cancer Center at Hill Radiation Oncology
-
Verona, New York, Forenede Stater, 13478
- Upstate Cancer Center at Verona
-
-
North Carolina
-
Cary, North Carolina, Forenede Stater, 27518
- Duke Cancer Institute Cary
-
Durham, North Carolina, Forenede Stater, 27710
- Duke University Medical Center
-
Greenville, North Carolina, Forenede Stater, 27834
- East Carolina University
-
Hendersonville, North Carolina, Forenede Stater, 28791
- Margaret R Pardee Memorial Hospital
-
Kenansville, North Carolina, Forenede Stater, 28349
- Vidant Oncology-Kenansville
-
Kinston, North Carolina, Forenede Stater, 28501
- Vidant Oncology-Kinston
-
New Bern, North Carolina, Forenede Stater, 28561
- CarolinaEast Medical Center
-
Pinehurst, North Carolina, Forenede Stater, 28374
- FirstHealth of the Carolinas-Moore Regional Hospital
-
Raleigh, North Carolina, Forenede Stater, 27609
- Duke Raleigh Hospital
-
Raleigh, North Carolina, Forenede Stater, 27607
- Duke Women's Cancer Care Raleigh
-
Richlands, North Carolina, Forenede Stater, 28574
- Vidant Oncology-Richlands
-
-
North Dakota
-
Bismarck, North Dakota, Forenede Stater, 58501
- Sanford Bismarck Medical Center
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Roger Maris Cancer Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Essentia Health Cancer Center-South University Clinic
-
Fargo, North Dakota, Forenede Stater, 58122
- Sanford Broadway Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Sanford South University Medical Center
-
Fargo, North Dakota, Forenede Stater, 58103
- Southpointe-Sanford Medical Center Fargo
-
Fargo, North Dakota, Forenede Stater, 58104
- Sanford Medical Center Fargo
-
Jamestown, North Dakota, Forenede Stater, 58401
- Essentia Health - Jamestown Clinic
-
-
Ohio
-
Akron, Ohio, Forenede Stater, 44307
- Cleveland Clinic Akron General
-
Akron, Ohio, Forenede Stater, 44304
- Summa Health System - Akron Campus
-
Barberton, Ohio, Forenede Stater, 44203
- Summa Health System - Barberton Campus
-
Beavercreek, Ohio, Forenede Stater, 45431
- Indu and Raj Soin Medical Center
-
Belpre, Ohio, Forenede Stater, 45714
- Strecker Cancer Center-Belpre
-
Boardman, Ohio, Forenede Stater, 44512
- Saint Elizabeth Boardman Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Cleveland Clinic Mercy Hospital
-
Canton, Ohio, Forenede Stater, 44708
- Mercy Hematology and Oncology Associates Inc
-
Centerville, Ohio, Forenede Stater, 45459
- Miami Valley Hospital South
-
Centerville, Ohio, Forenede Stater, 45459
- Dayton Physicians LLC-Miami Valley South
-
Chillicothe, Ohio, Forenede Stater, 45601
- Adena Regional Medical Center
-
Cincinnati, Ohio, Forenede Stater, 45220
- Good Samaritan Hospital - Cincinnati
-
Cincinnati, Ohio, Forenede Stater, 45242
- Bethesda North Hospital
-
Cincinnati, Ohio, Forenede Stater, 45236
- Oncology Hematology Care Inc-Kenwood
-
Cincinnati, Ohio, Forenede Stater, 45247
- TriHealth Cancer Institute-Westside
-
Cincinnati, Ohio, Forenede Stater, 45255
- TriHealth Cancer Institute-Anderson
-
Cleveland, Ohio, Forenede Stater, 44109
- MetroHealth Medical Center
-
Cleveland, Ohio, Forenede Stater, 44195
- Cleveland Clinic Foundation
-
Cleveland, Ohio, Forenede Stater, 44111
- Cleveland Clinic Cancer Center/Fairview Hospital
-
Columbus, Ohio, Forenede Stater, 43214
- Riverside Methodist Hospital
-
Columbus, Ohio, Forenede Stater, 43219
- The Mark H Zangmeister Center
-
Columbus, Ohio, Forenede Stater, 43214
- Columbus Oncology and Hematology Associates Inc
-
Columbus, Ohio, Forenede Stater, 43228
- Doctors Hospital
-
Columbus, Ohio, Forenede Stater, 43213
- Mount Carmel East Hospital
-
Columbus, Ohio, Forenede Stater, 43215
- Grant Medical Center
-
Columbus, Ohio, Forenede Stater, 43222
- Mount Carmel Health Center West
-
Dayton, Ohio, Forenede Stater, 45409
- Miami Valley Hospital
-
Dayton, Ohio, Forenede Stater, 45415
- Dayton Physician LLC-Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45415
- Miami Valley Hospital North
-
Dayton, Ohio, Forenede Stater, 45409
- Dayton Blood and Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Delaware Health Center-Grady Cancer Center
-
Delaware, Ohio, Forenede Stater, 43015
- Grady Memorial Hospital
-
Dublin, Ohio, Forenede Stater, 43016
- Dublin Methodist Hospital
-
Dublin, Ohio, Forenede Stater, 43016
- Columbus Oncology and Hematology Associates
-
Findlay, Ohio, Forenede Stater, 45840
- Blanchard Valley Hospital
-
Findlay, Ohio, Forenede Stater, 45840
- Armes Family Cancer Center
-
Findlay, Ohio, Forenede Stater, 45840
- Orion Cancer Care
-
Franklin, Ohio, Forenede Stater, 45005-1066
- Atrium Medical Center-Middletown Regional Hospital
-
Franklin, Ohio, Forenede Stater, 45005
- Dayton Physicians LLC-Atrium
-
Gahanna, Ohio, Forenede Stater, 43230
- Central Ohio Breast and Endocrine Surgery
-
Greenville, Ohio, Forenede Stater, 45331
- Wayne Hospital
-
Greenville, Ohio, Forenede Stater, 45331
- Dayton Physicians LLC-Wayne
-
Greenville, Ohio, Forenede Stater, 45331
- Miami Valley Cancer Care and Infusion
-
Grove City, Ohio, Forenede Stater, 43123
- Mount Carmel Grove City Hospital
-
Grove City, Ohio, Forenede Stater, 43123
- Zangmeister Center Grove City
-
Independence, Ohio, Forenede Stater, 44131
- Cleveland Clinic Cancer Center Independence
-
Kettering, Ohio, Forenede Stater, 45429
- Kettering Medical Center
-
Kettering, Ohio, Forenede Stater, 45409
- Greater Dayton Cancer Center
-
Kettering, Ohio, Forenede Stater, 45420
- First Dayton Cancer Care
-
Lancaster, Ohio, Forenede Stater, 43130
- Fairfield Medical Center
-
Lima, Ohio, Forenede Stater, 45801
- Saint Rita's Medical Center
-
Mansfield, Ohio, Forenede Stater, 44906
- Cleveland Clinic Cancer Center Mansfield
-
Mansfield, Ohio, Forenede Stater, 44903
- OhioHealth Mansfield Hospital
-
Marietta, Ohio, Forenede Stater, 45750
- Marietta Memorial Hospital
-
Marion, Ohio, Forenede Stater, 43302
- OhioHealth Marion General Hospital
-
Mayfield Heights, Ohio, Forenede Stater, 44124
- Hillcrest Hospital Cancer Center
-
Medina, Ohio, Forenede Stater, 44256
- Summa Health Medina Medical Center
-
Mount Vernon, Ohio, Forenede Stater, 43050
- Knox Community Hospital
-
New Albany, Ohio, Forenede Stater, 43054
- Mount Carmel New Albany Surgical Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Licking Memorial Hospital
-
Newark, Ohio, Forenede Stater, 43055
- Newark Radiation Oncology
-
Perrysburg, Ohio, Forenede Stater, 43551
- Mercy Health Perrysburg Cancer Center
-
Portsmouth, Ohio, Forenede Stater, 45662
- Southern Ohio Medical Center
-
Sandusky, Ohio, Forenede Stater, 44870
- North Coast Cancer Care
-
Springfield, Ohio, Forenede Stater, 45505
- Springfield Regional Medical Center
-
Springfield, Ohio, Forenede Stater, 45504
- Springfield Regional Cancer Center
-
Strongsville, Ohio, Forenede Stater, 44136
- Cleveland Clinic Cancer Center Strongsville
-
Toledo, Ohio, Forenede Stater, 43608
- Saint Vincent Mercy Medical Center
-
Toledo, Ohio, Forenede Stater, 43623
- Mercy Health - Saint Anne Hospital
-
Troy, Ohio, Forenede Stater, 45373
- Upper Valley Medical Center
-
Troy, Ohio, Forenede Stater, 45373
- Dayton Physicians LLC - Troy
-
Warren, Ohio, Forenede Stater, 44484
- Saint Joseph Warren Hospital
-
Warrensville Heights, Ohio, Forenede Stater, 44122
- South Pointe Hospital
-
Westerville, Ohio, Forenede Stater, 43081
- Saint Ann's Hospital
-
Wooster, Ohio, Forenede Stater, 44691
- Cleveland Clinic Wooster Family Health and Surgery Center
-
Youngstown, Ohio, Forenede Stater, 44501
- Saint Elizabeth Youngstown Hospital
-
Zanesville, Ohio, Forenede Stater, 43701
- Genesis Healthcare System Cancer Care Center
-
-
Oklahoma
-
Lawton, Oklahoma, Forenede Stater, 73505
- Cancer Centers of Southwest Oklahoma Research
-
Oklahoma City, Oklahoma, Forenede Stater, 73104
- University of Oklahoma Health Sciences Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73120
- Mercy Hospital Oklahoma City
-
Oklahoma City, Oklahoma, Forenede Stater, 73109
- Integris Southwest Medical Center
-
Oklahoma City, Oklahoma, Forenede Stater, 73142
- Integris Cancer Institute of Oklahoma
-
-
Oregon
-
Baker City, Oregon, Forenede Stater, 97814
- Saint Alphonsus Medical Center-Baker City
-
Bend, Oregon, Forenede Stater, 97701
- Saint Charles Health System
-
Clackamas, Oregon, Forenede Stater, 97015
- Clackamas Radiation Oncology Center
-
Clackamas, Oregon, Forenede Stater, 97015
- Providence Cancer Institute Clackamas Clinic
-
Coos Bay, Oregon, Forenede Stater, 97420
- Bay Area Hospital
-
Corvallis, Oregon, Forenede Stater, 97330
- Good Samaritan Hospital
-
Newberg, Oregon, Forenede Stater, 97132
- Providence Newberg Medical Center
-
Ontario, Oregon, Forenede Stater, 97914
- Saint Alphonsus Medical Center-Ontario
-
Oregon City, Oregon, Forenede Stater, 97045
- Providence Willamette Falls Medical Center
-
Portland, Oregon, Forenede Stater, 97213
- Providence Portland Medical Center
-
Portland, Oregon, Forenede Stater, 97225
- Providence Saint Vincent Medical Center
-
Redmond, Oregon, Forenede Stater, 97756
- Saint Charles Health System-Redmond
-
-
Pennsylvania
-
Allentown, Pennsylvania, Forenede Stater, 18103
- Lehigh Valley Hospital-Cedar Crest
-
Altoona, Pennsylvania, Forenede Stater, 16601
- UPMC Altoona
-
Beaver, Pennsylvania, Forenede Stater, 15009
- UPMC-Heritage Valley Health System Beaver
-
Bethlehem, Pennsylvania, Forenede Stater, 18017
- Lehigh Valley Hospital - Muhlenberg
-
Bryn Mawr, Pennsylvania, Forenede Stater, 19010
- Bryn Mawr Hospital
-
Camp Hill, Pennsylvania, Forenede Stater, 17011
- UPMC Camp Hill
-
Carlisle, Pennsylvania, Forenede Stater, 17015
- Carlisle Regional Cancer Center
-
Chadds Ford, Pennsylvania, Forenede Stater, 19317
- Christiana Care Health System-Concord Health Center
-
Collegeville, Pennsylvania, Forenede Stater, 19426
- Main Line Health Center-Collegeville
-
Danville, Pennsylvania, Forenede Stater, 17822
- Geisinger Medical Center
-
East Stroudsburg, Pennsylvania, Forenede Stater, 18301
- Pocono Medical Center
-
Erie, Pennsylvania, Forenede Stater, 16505
- UPMC Hillman Cancer Center Erie
-
Exton, Pennsylvania, Forenede Stater, 19341
- Main Line Health Center-Exton
-
Farrell, Pennsylvania, Forenede Stater, 16121
- UPMC Cancer Center at UPMC Horizon
-
Greensburg, Pennsylvania, Forenede Stater, 15601
- UPMC Cancer Centers - Arnold Palmer Pavilion
-
Greenville, Pennsylvania, Forenede Stater, 16125
- UPMC Hillman Cancer Center in Greenville/UPMC Horizon
-
Harrisburg, Pennsylvania, Forenede Stater, 17109
- UPMC Pinnacle Cancer Center/Community Osteopathic Campus
-
Harrisburg, Pennsylvania, Forenede Stater, 17101
- UPMC Pinnacle Harrisburg
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Geisinger Medical Center-Cancer Center Hazleton
-
Hazleton, Pennsylvania, Forenede Stater, 18201
- Lehigh Valley Hospital-Hazleton
-
Hershey, Pennsylvania, Forenede Stater, 17033-0850
- Penn State Milton S Hershey Medical Center
-
Johnstown, Pennsylvania, Forenede Stater, 15901
- UPMC-Johnstown/John P. Murtha Regional Cancer Center
-
Lewisburg, Pennsylvania, Forenede Stater, 17837
- Geisinger Medical Oncology-Lewisburg
-
McKeesport, Pennsylvania, Forenede Stater, 15132
- UPMC Cancer Center at UPMC McKeesport
-
Mechanicsburg, Pennsylvania, Forenede Stater, 17050
- UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
-
Media, Pennsylvania, Forenede Stater, 19063
- Riddle Memorial Hospital
-
Monroeville, Pennsylvania, Forenede Stater, 15146
- UPMC Cancer Center - Monroeville
-
Moon, Pennsylvania, Forenede Stater, 15108
- UPMC Hillman Cancer Center in Coraopolis
-
N. Huntingdon, Pennsylvania, Forenede Stater, 15642
- Arnold Palmer Cancer Center Medical Oncology Norwin
-
New Castle, Pennsylvania, Forenede Stater, 16105
- UPMC Hillman Cancer Center - New Castle
-
Paoli, Pennsylvania, Forenede Stater, 19301
- Paoli Memorial Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15213
- UPMC-Magee Womens Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- University of Pittsburgh Cancer Institute (UPCI)
-
Pittsburgh, Pennsylvania, Forenede Stater, 15232
- UPMC-Shadyside Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15215
- UPMC-Saint Margaret
-
Pittsburgh, Pennsylvania, Forenede Stater, 15237
- UPMC-Passavant Hospital
-
Pittsburgh, Pennsylvania, Forenede Stater, 15243
- UPMC-Saint Clair Hospital Cancer Center
-
Pottstown, Pennsylvania, Forenede Stater, 19464
- Pottstown Hospital
-
Pottsville, Pennsylvania, Forenede Stater, 17901
- Geisinger Cancer Services-Pottsville
-
Sayre, Pennsylvania, Forenede Stater, 18840
- Guthrie Medical Group PC-Robert Packer Hospital
-
Scranton, Pennsylvania, Forenede Stater, 18510
- Community Medical Center
-
Seneca, Pennsylvania, Forenede Stater, 16346
- UPMC Cancer Center at UPMC Northwest
-
Uniontown, Pennsylvania, Forenede Stater, 15401
- UPMC Uniontown Hospital Radiation Oncology
-
Washington, Pennsylvania, Forenede Stater, 15301
- UPMC Washington Hospital Radiation Oncology
-
Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
- Geisinger Wyoming Valley/Henry Cancer Center
-
Wynnewood, Pennsylvania, Forenede Stater, 19096
- Lankenau Medical Center
-
York, Pennsylvania, Forenede Stater, 17408
- UPMC Memorial
-
-
South Carolina
-
Gaffney, South Carolina, Forenede Stater, 29341
- Gibbs Cancer Center-Gaffney
-
Greer, South Carolina, Forenede Stater, 29651
- Gibbs Cancer Center-Pelham
-
Hilton Head Island, South Carolina, Forenede Stater, 29926
- The Radiation Oncology Center-Hilton Head/Bluffton
-
Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
- South Carolina Cancer Specialists PC
-
Myrtle Beach, South Carolina, Forenede Stater, 29577
- Carolina Regional Cancer Center
-
Spartanburg, South Carolina, Forenede Stater, 29303
- Spartanburg Medical Center
-
Spartanburg, South Carolina, Forenede Stater, 29307
- Spartanburg Medical Center - Mary Black Campus
-
Spartanburg, South Carolina, Forenede Stater, 29303
- North Grove Medical Park
-
Union, South Carolina, Forenede Stater, 29379
- MGC Hematology Oncology-Union
-
-
Tennessee
-
Collierville, Tennessee, Forenede Stater, 38017
- Baptist Memorial Hospital and Cancer Center-Collierville
-
Memphis, Tennessee, Forenede Stater, 38120
- Baptist Memorial Hospital and Cancer Center-Memphis
-
-
Texas
-
Bryan, Texas, Forenede Stater, 77802
- Saint Joseph Regional Cancer Center
-
Houston, Texas, Forenede Stater, 77030
- Memorial Hermann Texas Medical Center
-
Humble, Texas, Forenede Stater, 77338
- Memorial Hermann Northeast Hospital
-
-
Vermont
-
Berlin, Vermont, Forenede Stater, 05602
- Central Vermont Medical Center/National Life Cancer Treatment
-
Burlington, Vermont, Forenede Stater, 05401
- University of Vermont Medical Center
-
Burlington, Vermont, Forenede Stater, 05405
- University of Vermont and State Agricultural College
-
Saint Johnsbury, Vermont, Forenede Stater, 05819
- Norris Cotton Cancer Center-North
-
-
Virginia
-
Charlottesville, Virginia, Forenede Stater, 22908
- University of Virginia Cancer Center
-
Lynchburg, Virginia, Forenede Stater, 24501
- Centra Lynchburg Hematology-Oncology Clinic Inc
-
Martinsville, Virginia, Forenede Stater, 24115
- Sovah Health Martinsville
-
Mechanicsville, Virginia, Forenede Stater, 23116
- VCU Massey Cancer Center at Hanover Medical Park
-
Richmond, Virginia, Forenede Stater, 23235
- VCU Massey Cancer Center at Stony Point
-
Richmond, Virginia, Forenede Stater, 23298
- Virginia Commonwealth University/Massey Cancer Center
-
Richmond, Virginia, Forenede Stater, 23229
- Virginia Cancer Institute
-
South Hill, Virginia, Forenede Stater, 23970
- VCU Community Memorial Health Center
-
Winchester, Virginia, Forenede Stater, 22601
- Shenandoah Oncology PC
-
-
Washington
-
Aberdeen, Washington, Forenede Stater, 98520
- Providence Regional Cancer System-Aberdeen
-
Bellevue, Washington, Forenede Stater, 98004
- Overlake Medical Center
-
Bellevue, Washington, Forenede Stater, 98004
- FHCC Overlake
-
Bellingham, Washington, Forenede Stater, 98225
- PeaceHealth Saint Joseph Medical Center
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison HealthPartners Hematology and Oncology-Bremerton
-
Bremerton, Washington, Forenede Stater, 98310
- Harrison Medical Center
-
Burien, Washington, Forenede Stater, 98166
- Highline Medical Center-Main Campus
-
Centralia, Washington, Forenede Stater, 98531
- Providence Regional Cancer System-Centralia
-
Edmonds, Washington, Forenede Stater, 98026
- Swedish Cancer Institute-Edmonds
-
Enumclaw, Washington, Forenede Stater, 98022
- Saint Elizabeth Hospital
-
Everett, Washington, Forenede Stater, 98201
- Providence Regional Cancer Partnership
-
Federal Way, Washington, Forenede Stater, 98003
- Saint Francis Hospital
-
Issaquah, Washington, Forenede Stater, 98029
- Swedish Cancer Institute-Issaquah
-
Kennewick, Washington, Forenede Stater, 99336
- Kadlec Clinic Hematology and Oncology
-
Kirkland, Washington, Forenede Stater, 98034
- Seattle Cancer Care Alliance at EvergreenHealth
-
Lacey, Washington, Forenede Stater, 98503
- Providence Regional Cancer System-Lacey
-
Lakewood, Washington, Forenede Stater, 98499
- Saint Clare Hospital
-
Longview, Washington, Forenede Stater, 98632
- PeaceHealth Saint John Medical Center
-
Port Townsend, Washington, Forenede Stater, 98368
- Jefferson Healthcare
-
Poulsbo, Washington, Forenede Stater, 98370
- Harrison HealthPartners Hematology and Oncology-Poulsbo
-
Renton, Washington, Forenede Stater, 98055
- Valley Medical Center
-
Seattle, Washington, Forenede Stater, 98107
- Swedish Medical Center-Ballard Campus
-
Seattle, Washington, Forenede Stater, 98122
- Swedish Medical Center-First Hill
-
Seattle, Washington, Forenede Stater, 98104
- Pacific Gynecology Specialists
-
Seattle, Washington, Forenede Stater, 98122-5711
- Swedish Medical Center-Cherry Hill
-
Seattle, Washington, Forenede Stater, 98133
- FHCC at Northwest Hospital
-
Sedro-Woolley, Washington, Forenede Stater, 98284
- PeaceHealth United General Medical Center
-
Shelton, Washington, Forenede Stater, 98584
- Providence Regional Cancer System-Shelton
-
Tacoma, Washington, Forenede Stater, 98405
- Northwest Medical Specialties PLLC
-
Tacoma, Washington, Forenede Stater, 98405
- Franciscan Research Center-Northwest Medical Plaza
-
Vancouver, Washington, Forenede Stater, 98664
- PeaceHealth Southwest Medical Center
-
Walla Walla, Washington, Forenede Stater, 99362
- Providence Saint Mary Regional Cancer Center
-
Yakima, Washington, Forenede Stater, 98902
- North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
-
Yelm, Washington, Forenede Stater, 98597
- Providence Regional Cancer System-Yelm
-
-
West Virginia
-
Charleston, West Virginia, Forenede Stater, 25304
- West Virginia University Charleston Division
-
Huntington, West Virginia, Forenede Stater, 25701
- Edwards Comprehensive Cancer Center
-
Morgantown, West Virginia, Forenede Stater, 26506
- West Virginia University Healthcare
-
Parkersburg, West Virginia, Forenede Stater, 26101
- Camden Clark Medical Center
-
Wheeling, West Virginia, Forenede Stater, 26003
- Wheeling Hospital/Schiffler Cancer Center
-
-
Wisconsin
-
Antigo, Wisconsin, Forenede Stater, 54409
- Langlade Hospital and Cancer Center
-
Appleton, Wisconsin, Forenede Stater, 54911
- ThedaCare Regional Cancer Center
-
Ashland, Wisconsin, Forenede Stater, 54806
- Duluth Clinic Ashland
-
Ashland, Wisconsin, Forenede Stater, 54806
- Northwest Wisconsin Cancer Center
-
Burlington, Wisconsin, Forenede Stater, 53105
- Aurora Cancer Care-Southern Lakes VLCC
-
Cudahy, Wisconsin, Forenede Stater, 53110
- Aurora Saint Luke's South Shore
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- Marshfield Medical Center-EC Cancer Center
-
Eau Claire, Wisconsin, Forenede Stater, 54701
- HSHS Sacred Heart Hospital
-
Germantown, Wisconsin, Forenede Stater, 53022
- Aurora Health Care Germantown Health Center
-
Grafton, Wisconsin, Forenede Stater, 53024
- Aurora Cancer Care-Grafton
-
Green Bay, Wisconsin, Forenede Stater, 54311
- Aurora BayCare Medical Center
-
Green Bay, Wisconsin, Forenede Stater, 54301
- Saint Vincent Hospital Cancer Center Green Bay
-
Green Bay, Wisconsin, Forenede Stater, 54303
- Saint Vincent Hospital Cancer Center at Saint Mary's
-
Hayward, Wisconsin, Forenede Stater, 54843
- Essentia Health-Hayward Clinic
-
Johnson Creek, Wisconsin, Forenede Stater, 53038
- UW Cancer Center Johnson Creek
-
Kenosha, Wisconsin, Forenede Stater, 53142
- Aurora Cancer Care-Kenosha South
-
La Crosse, Wisconsin, Forenede Stater, 54601
- Gundersen Lutheran Medical Center
-
Madison, Wisconsin, Forenede Stater, 53792
- University of Wisconsin Carbone Cancer Center
-
Marinette, Wisconsin, Forenede Stater, 54143
- Aurora Bay Area Medical Group-Marinette
-
Marshfield, Wisconsin, Forenede Stater, 54449
- Marshfield Medical Center-Marshfield
-
Medford, Wisconsin, Forenede Stater, 54451
- Aspirus Medford Hospital
-
Menomonee Falls, Wisconsin, Forenede Stater, 53051
- Froedtert Menomonee Falls Hospital
-
Milwaukee, Wisconsin, Forenede Stater, 53226
- Medical College of Wisconsin
-
Milwaukee, Wisconsin, Forenede Stater, 53209
- Aurora Cancer Care-Milwaukee
-
Milwaukee, Wisconsin, Forenede Stater, 53215
- Aurora Saint Luke's Medical Center
-
Milwaukee, Wisconsin, Forenede Stater, 53233
- Aurora Sinai Medical Center
-
Minocqua, Wisconsin, Forenede Stater, 54548
- Marshfield Clinic-Minocqua Center
-
Mukwonago, Wisconsin, Forenede Stater, 53149
- ProHealth D N Greenwald Center
-
Neenah, Wisconsin, Forenede Stater, 54956
- ThedaCare Regional Medical Center - Neenah
-
New Richmond, Wisconsin, Forenede Stater, 54017
- Cancer Center of Western Wisconsin
-
Oak Creek, Wisconsin, Forenede Stater, 53154
- Drexel Town Square Health Center
-
Oconomowoc, Wisconsin, Forenede Stater, 53066
- ProHealth Oconomowoc Memorial Hospital
-
Oshkosh, Wisconsin, Forenede Stater, 54904
- Vince Lombardi Cancer Clinic - Oshkosh
-
Racine, Wisconsin, Forenede Stater, 53406
- Aurora Cancer Care-Racine
-
Rhinelander, Wisconsin, Forenede Stater, 54501
- Ascension Saint Mary's Hospital
-
Rice Lake, Wisconsin, Forenede Stater, 54868
- Marshfield Medical Center-Rice Lake
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Vince Lombardi Cancer Clinic-Sheboygan
-
Sheboygan, Wisconsin, Forenede Stater, 53081
- Saint Vincent Hospital Cancer Center at Sheboygan
-
Spooner, Wisconsin, Forenede Stater, 54801
- Essentia Health-Spooner Clinic
-
Stevens Point, Wisconsin, Forenede Stater, 54481
- Ascension Saint Michael's Hospital
-
Stevens Point, Wisconsin, Forenede Stater, 54482
- Marshfield Medical Center-River Region at Stevens Point
-
Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
- Saint Vincent Hospital Cancer Center at Sturgeon Bay
-
Summit, Wisconsin, Forenede Stater, 53066
- Aurora Medical Center in Summit
-
Superior, Wisconsin, Forenede Stater, 54880
- Essentia Health Saint Mary's Hospital - Superior
-
Two Rivers, Wisconsin, Forenede Stater, 54241
- Vince Lombardi Cancer Clinic-Two Rivers
-
Waukesha, Wisconsin, Forenede Stater, 53188
- UW Cancer Center at ProHealth Care
-
Waukesha, Wisconsin, Forenede Stater, 53188
- ProHealth Waukesha Memorial Hospital
-
Wausau, Wisconsin, Forenede Stater, 54401
- Aspirus Regional Cancer Center
-
Wauwatosa, Wisconsin, Forenede Stater, 53226
- Aurora Cancer Care-Milwaukee West
-
West Allis, Wisconsin, Forenede Stater, 53227
- Aurora West Allis Medical Center
-
West Bend, Wisconsin, Forenede Stater, 53095
- Froedtert West Bend Hospital/Kraemer Cancer Center
-
Weston, Wisconsin, Forenede Stater, 54476
- Marshfield Medical Center - Weston
-
Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
- Aspirus Cancer Care - Wisconsin Rapids
-
-
Wyoming
-
Cheyenne, Wyoming, Forenede Stater, 82001
- Cheyenne Regional Medical Center-West
-
Cody, Wyoming, Forenede Stater, 82414
- Billings Clinic-Cody
-
Sheridan, Wyoming, Forenede Stater, 82801
- Welch Cancer Center
-
-
-
-
-
Tamuning, Guam, 96913
- FHP Health Center-Guam
-
-
Deltagelseskriterier
Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.
Berettigelseskriterier
Aldre berettiget til at studere
18 år og ældre (Voksen, Ældre voksen)
Tager imod sunde frivillige
Ingen
Beskrivelse
Inklusionskriterier:
- TRIN 1 INKLUSION BERETNINGSKRITERIER - SAMTYDLIG BEHANDLING
- Patienten skal være >= 18 år gammel
Patienten skal have en af følgende:
- Nydiagnosticeret fase IIIA/B/C ikke-småcellet lungekræft (NSCLC) (ifølge American Joint Committee on Cancer [AJCC] 8. udgave), som er uoperabel og er histologisk og/eller cytologisk bekræftet
- Nodal recidiv efter operation for tidligt stadium NSCLC
- Patienten skal have en Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 eller 1
- Patienten skal have en kropsvægt > 30 kg
- Patienten må ikke have utilsigtet vægttab > 10 % inden for 30 dage før registrering
- Patienten skal have foretaget en baseline elektrokardiografi (EKG) inden for 6 uger før registrering
- Patienten skal have målbar sygdom i henhold til responsevalueringskriterier i solide tumorer (RECIST) version (v)1.1. Baseline billeddannelsesvurderinger og målinger, der bruges til at evaluere alle målbare eller ikke-målbare sygdomssteder, skal udføres inden for 4 uger før registrering
- Absolut neutrofiltal (ANC) >= 1500 celler/uL (opnået =< 7 dage før registrering)
- Antal hvide blodlegemer (WBC) >= 2500/uL (opnået =< 7 dage før registrering)
- Blodpladetal >= 100.000/uL (opnået =< 7 dage før registrering)
- Hæmoglobin >= 9,0 g/dL (opnået =< 7 dage før registrering)
- Total bilirubin =< 1,5 x institutionel øvre normalgrænse (ULN) med følgende undtagelse: patienter med kendt Gilbert-sygdom, som har serumbilirubinniveau < 3 x ULN, kan tilmeldes (opnået =< 7 dage før registrering)
- Aspartataminotransferase (AST) og alanintransaminase (ALT) =< 3,0 x institutionel ULN (opnået =< 7 dage før registrering)
- Serumkreatinin =< 1,5 x institutionel ULN eller kreatininclearance >= 45 ml/min på basis af Cockcroft-Gault glomerulære filtrationshastighedestimering (opnået =< 7 dage før registrering)
- Patienten skal have lungefunktionsprøver (PFT'er) med både forceret ekspiratorisk volumen på 1 sekund (FEV1) og diffusionskapacitet i lungen for kulilte (DLCO) >= 40 % af forventet, opnået inden for 5 måneder før registrering
- Patienten forventes at have lungevolumen (V)20 på =< 35 %, efter at stråleonkolog har set, at forbehandlingen er oparbejdet
Patienter med nodal recidiv efter operation for tidligt stadie af NSCLC er kvalificerede, hvis følgende kriterier er opfyldt:
- Ingen tidligere kemoterapi eller stråling blev nogensinde administreret for denne lungecancer oprindeligt eller for tilbagefald før indtastning af denne protokol
- Forudgående operation med kurativ hensigt var mindst 90 dage før det nodale recidiv
- Ingen tidligere stråling blev administreret til området for undersøgelseskræft, som ville forårsage overlapning af behandlingsfelter
Patienter, der er positive med humant immundefektvirus (HIV) kan deltage i undersøgelsen, HVIS de opfylder alle følgende berettigelseskrav:
- De skal være stabile på deres antiretrovirale kur, og de skal være sunde ud fra et hiv-perspektiv
- De skal have et CD4-tal på mere end 250 celler/mcL, opnået inden for 6 måneder før registrering
- De må ikke modtage profylaktisk behandling for en opportunistisk infektion
- Patienter med en tidligere eller samtidig malignitet, hvis naturlige historie eller behandling ikke har potentiale til at interferere med sikkerheds- eller effektivitetsvurderingen af undersøgelsesregimet, er kvalificerede til dette forsøg. Patienter må ikke have fået kemoterapi eller strålebehandling inden for 4 uger (6 uger for nitrosoureas eller mitomycin C) før registrering
- Patienten må ikke være gravid eller ammende på grund af den potentielle skade på et ufødt foster og mulig risiko for bivirkninger hos ammende spædbørn med de behandlingsregimer, der anvendes.
- Alle patienter i den fødedygtige alder skal have en negativ blodprøve eller urinundersøgelse med en minimumsfølsomhed på 50 mlU/L eller tilsvarende enheder af HCG inden for 7 dage før registrering for at udelukke graviditet. En patient i den fødedygtige alder er enhver, uanset seksuel orientering eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) har opnået menarche på et tidspunkt, 2) ikke har gennemgået en hysterektomi eller bilateral oophorektomi; eller 3) ikke har været naturligt postmenopausal (amenoré efter cancerterapi udelukker ikke den fødedygtige alder) i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder).
Patienter må ikke forventes at blive gravide eller få børn ved at bruge accepterede og yderst effektive præventionsmetoder under samleje i mindst en uge før behandlingsstart, under protokolbehandling og fortsætte i 90 dage efter den sidste dosis af protokol behandling.
- Meget effektive præventionsmetoder omfatter Etonogestrel-frigivende implantater (Implanon eller Norplant), Intravaginal: Ethinylestradiol/etonogestrel-frigivende intravaginale anordninger: f.eks. NuvaRing, injektion: Medroxyprogesteron-injektion: f.eks. p-pille, plaster: Norelgestromin/ethinylestradiol-frigørende transdermalt system: f.eks. Ortho Evra, Minipillc: Progesteronbaseret p-pille med desogestrel: Cerazette er i øjeblikket den eneste højeffektive progesteronbaserede pille
- Metoder, der anses for utilstrækkelige, omfatter mandlige eller kvindelige kondomer med eller uden spermicid; hunkatte, mellemgulv eller svamp med eller uden sæddræbende middel; ikke-kobberholdig intrauterin anordning; orale hormonelle p-piller, der kun indeholder gestagen, hvor hæmning af ægløsning ikke er den primære virkningsmåde [undtagen Cerazette/desogestrel, som anses for meget effektivt]; og triphasiske kombinerede p-piller)
- TRIN 2 INKLUSIONSBERETNINGSKRITERIER - KONSOLIDERING
- Patienter med > grad 2 ikke-hæmatologisk eller > grad 3 hæmatologisk toksicitet skal komme sig til grad 2 (eller mindre) inden for 45 dage efter afslutningen af trin 1 samtidig kemo/stråling, med undtagelse af alopeci og vitiligo
Ekskluderingskriterier:
- TRIN 1 UDELUKKELSESKRITERIER - SAMTYDLIG BEHANDLING
- Patienten må ikke have nogen aktiv, kendt eller mistænkt autoimmun sygdom og neuromuskulære paraneoplastiske syndromer, herunder, men ikke begrænset til, myasthenia gravis, Lambert-Eaton myasthenisk syndrom, limbisk encephalitis, myositis, Guillain-Barré, systemisk lupus erythematosus og systemisk sklerose. Patienter med type I-diabetes mellitus, der kræver insulin, hypothyroidisme, der kun kræver hormonudskiftning, hudlidelser (såsom vitiligo, psoriasis eller alopeci), der ikke kræver systemisk behandling, eller tilstande, der ikke forventes at gentage sig uden en ekstern trigger, er kvalificerede
- Patienten må ikke have en historie med aktiv hepatitis B (kronisk eller akut) eller hepatitis C-infektion. Patienter med tidligere eller løst hepatitis B-infektion (defineret som at have en negativ hepatitis B overfladeantigen [HBsAg] test og en positiv anti-HBc [antistof mod hepatitis B kerne antigen] antistoftest) er kvalificerede. Patienter, der er positive for hepatitis C-virus (HCV)-antistof, er kun kvalificerede, hvis polymerasekædereaktion (PCR) er negativ for hepatitis C-virus-ribonukleinsyre (HCV RNA)
- Patienten må ikke have en kendt aktiv tuberkuloseinfektion
- Patienten må ikke have nogen alvorlige infektioner inden for 4 uger før registrering, inklusive, men ikke begrænset til, hospitalsindlæggelse for komplikationer af infektion, bakteriemi eller svær lungebetændelse
- Patienten må ikke have tegn eller symptomer på alvorlig infektion (sepsis) inden for 2 uger før registrering
- Patienten må ikke være blevet behandlet med systemiske immunstimulerende midler (herunder men ikke begrænset til interferon-a [IFN-a], interleukin [IL]-2) inden for 6 uger eller fem halveringstider af lægemidlet (alt efter hvad der er kortest) før registrering; eller behandlet med et forsøgsmiddel inden for 4 uger før registrering (eller inden for fem halveringstider af forsøgsmidlet, alt efter hvad der er længst)
- Patienten må ikke have en historie med alvorlige allergiske, anafylaktiske eller andre overfølsomhedsreaktioner over for kimære eller humaniserede antistoffer eller fusionsproteiner
- Patienten må ikke have været behandlet med systemisk immunsuppressiv medicin (svarende til > 10 mg prednison pr. dag) eller anden immunsuppressiv medicin inden for 7 dage før registrering. Inhalerede eller topikale steroider og binyrerstatningssteroiddoser svarende til > 10 mg prednison pr. dag er tilladt i fravær af aktiv autoimmun sygdom
- Patienten må ikke have haft en tidligere allogen knoglemarvstransplantation eller tidligere solid organtransplantation
- Patienten må ikke have en historie med idiopatisk lungefibrose, pneumonitis (herunder lægemiddelinduceret), organiserende lungebetændelse (dvs. bronchiolitis obliterans, kryptogene organiserende lungebetændelse osv.) eller tegn på aktiv lungebetændelse ved screening af thoraxcomputertomografi (CT) scanning inden for 4 uger før tilmelding
- Patienten må ikke have haft nogen tidligere systemisk behandling med et anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CTLA-4 antistof eller noget andet antistof eller lægemiddel, der er specifikt målrettet mod T-cellecostimulering eller immunforsvar. checkpoint veje
- Patienter med kendt anamnese eller aktuelle symptomer på hjertesygdom, eller historie med behandling med kardiotoksiske midler, bør have en klinisk risikovurdering og sværhedsgraden af hjertesymptomer. Symptomerne skal være stabile over de seneste 3 måneder. Specifikt må patienten ikke have koronar bypasstransplantation, myokardieinfarkt, akut koronarsyndrom, svær/ustabil angina, slagtilfælde, forbigående iskæmisk anfald eller hjertesvigt indlæggelse inden for 3 måneder før registrering
- Patienten må ikke have en ukontrolleret interkurrent sygdom, herunder, men ikke begrænset til, igangværende eller aktiv infektion, symptomatisk kongestiv hjertesvigt, ukontrolleret hypertension, ustabil angina pectoris, hjertearytmi, interstitiel lungesygdom, alvorlige kroniske gastrointestinale tilstande forbundet med diarré eller psykiatrisk sygdom /sociale situationer, der ville begrænse overholdelse af undersøgelseskrav, væsentligt øge risikoen for at pådrage sig uønskede hændelser (AE'er) eller kompromittere patientens evne til at give skriftligt informeret samtykke
- Patienten må ikke have modtaget en levende, svækket vaccine inden for 4 uger før registrering
- Patienten må ikke have haft tidligere stråling til det aktuelle påtænkte behandlingssted
- Patienten må ikke donere blod eller sæd under undersøgelsesbehandling
- TRIN 2 UDELUKKELSESBERETNINGSKRITERIER - KONSOLIDERING
- Patienten må ikke modtage nogen non-protokol anti-kræftbehandling efter afslutningen af trin 1 kemo/stråling eller under trin 2 konsolidering
- Patienter med mistanke om tilfælde af >= grad 2 pneumonitis (ikke-infektiøs) er ikke kvalificerede til Trin 2 konsoliderende MEDI4736 (durvalumab) og vil i stedet fortsætte med opfølgning
- Patienten må ikke have sygdomsprogression på den første efterbehandling (trin 1 for samtidig kemo/stråling) CT-scanning af brystet, som skal foretages inden for 14 dage efter den sidste dosis strålebehandling. Hvis det er tilfældet, er patienten ikke berettiget til Trin 2-konsolidativ MEDI4736 (durvalumab) og vil i stedet fortsætte med opfølgning
Studieplan
Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.
Hvordan er undersøgelsen tilrettelagt?
Design detaljer
- Primært formål: Behandling
- Tildeling: Randomiseret
- Interventionel model: Parallel tildeling
- Maskning: Ingen (Åben etiket)
Våben og indgreb
Deltagergruppe / Arm |
Intervention / Behandling |
|---|---|
|
Eksperimentel: Arm A (durvalumab, kemoterapi, durvalumab)
TRIN 1 (SAMTIDIGT BEHANDLING): Patienterne får durvalumab IV over 60 minutter på dag 1 og 15 i cyklus 1 og dag 1 i cyklus 2. Patienterne modtager også 1 ud af 3 behandlingsregimer pr. investigatorvalg: 1) etoposid IV over 60 minutter på dage 1-5 og cisplatin IV over 60 minutter på dag 1 og 8 hver 28. dag i 2 cyklusser; 2) pemetrexed dinatrium IV over 60 minutter og cisplatin IV over 60-120 minutter på dag 1 hver 21. dag i 2 cyklusser; eller 3) paclitaxel IV over 60 minutter og carboplatin IV over 30 minutter på dag 1 hver 7. dag i 6 cyklusser. Behandlingen fortsætter i fravær af sygdomsprogression eller uacceptabel toksicitet. Fra dag 1 af kemoterapi modtager patienter strålebehandling 5 dage om ugen i 6 uger. TRIN 2 (KONSOLIDERINGSBEHANDLING): Inden for 14 dage efter den sidste stråledosis (fra trin 1) får alle patienter derefter durvalumab IV over 60 minutter på dag 1. Behandlingen gentages hver 28. dag i 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. |
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
|
|
Aktiv komparator: Arm B (kemoterapi, durvalumab)
TRIN 1 (SAMTIDIGT BEHANDLING): Patienterne modtager 1 ud af 3 investigators valgbehandlingsregimer og strålebehandling som i arm A. TRIN 2 (KONSOLIDERINGSBEHANDLING): Inden for 14 dage efter den sidste stråledosis (fra trin 1) får alle patienter derefter durvalumab IV over 60 minutter på dag 1. Behandlingen gentages hver 28. dag i 12 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. |
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
Givet IV
Andre navne:
|
Hvad måler undersøgelsen?
Primære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Samlet overlevelse (OS)
Tidsramme: Fra randomisering til død uanset årsag, vurderet op til 10 år
|
Vil blive estimeret ved hjælp af Kaplan-Meier metoden, og Cox proportional hazards modeller vil blive brugt til at estimere behandlingsfareforhold.
Den primære sammenligning af OS vil bruge en logrank test stratificeret på randomiseringsstratificeringsfaktorerne med en ensidig type I fejlrate på 2,5 %.
|
Fra randomisering til død uanset årsag, vurderet op til 10 år
|
Sekundære resultatmål
Resultatmål |
Foranstaltningsbeskrivelse |
Tidsramme |
|---|---|---|
|
Progressionsfri overlevelse (PFS)
Tidsramme: Fra randomisering til dokumenteret sygdomsprogression pr. responsevalueringskriterier i solide tumorer (RECIST) 1.1 eller død af enhver årsag, alt efter hvad der indtræffer først, vurderet i op til 10 år
|
Vil blive estimeret ved hjælp af Kaplan-Meier metoden, og Cox proportional hazards modeller vil blive brugt til at estimere behandlingsfareforhold.
|
Fra randomisering til dokumenteret sygdomsprogression pr. responsevalueringskriterier i solide tumorer (RECIST) 1.1 eller død af enhver årsag, alt efter hvad der indtræffer først, vurderet i op til 10 år
|
|
Bedste objektive svar
Tidsramme: Op til 10 år
|
Vil blive evalueret via RECIST1.1 kriterier.
vil blive sammenlignet ved hjælp af Fishers eksakte test med en ensidig type I fejlrate på 2,5%.
|
Op til 10 år
|
|
Forekomst af uønskede hændelser
Tidsramme: Op til 10 år
|
Toksicitet vil blive bestemt ved hjælp af CTCAE-kriterierne (Common Terminology Criteria for Adverse Events).
vil blive sammenlignet ved hjælp af Fishers eksakte test med en ensidig type I fejlrate på 2,5 %
|
Op til 10 år
|
|
Lokal progression
Tidsramme: Op til 10 år
|
Vil blive defineret som enhver progression begrænset til den ipsilaterale lunge eller N1-N3 nodale områder.
|
Op til 10 år
|
Samarbejdspartnere og efterforskere
Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.
Sponsor
Efterforskere
- Ledende efterforsker: Nathan A Pennell, ECOG-ACRIN Cancer Research Group
Datoer for undersøgelser
Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.
Studer store datoer
Studiestart (Faktiske)
29. april 2020
Primær færdiggørelse (Anslået)
31. december 2028
Studieafslutning (Anslået)
31. december 2028
Datoer for studieregistrering
Først indsendt
16. september 2019
Først indsendt, der opfyldte QC-kriterier
16. september 2019
Først opslået (Faktiske)
17. september 2019
Opdateringer af undersøgelsesjournaler
Sidste opdatering sendt (Anslået)
15. april 2024
Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier
12. april 2024
Sidst verificeret
1. november 2023
Mere information
Begreber relateret til denne undersøgelse
Yderligere relevante MeSH-vilkår
- Luftvejssygdomme
- Neoplasmer efter histologisk type
- Neoplasmer
- Lungesygdomme
- Neoplasmer efter sted
- Neoplasmer, kirtel og epitel
- Neoplasmer i luftvejene
- Thoracale neoplasmer
- Karcinom, bronkogent
- Bronkiale neoplasmer
- Lungeneoplasmer
- Karcinom, ikke-småcellet lunge
- Karcinom
- Lægemidlers fysiologiske virkninger
- Molekylære mekanismer for farmakologisk virkning
- Nukleinsyresyntesehæmmere
- Enzymhæmmere
- Antineoplastiske midler
- Immunologiske faktorer
- Tubulin modulatorer
- Antimitotiske midler
- Mitose modulatorer
- Antineoplastiske midler, fytogene
- Topoisomerase II-hæmmere
- Topoisomerasehæmmere
- Antineoplastiske midler, immunologiske
- Dermatologiske midler
- Keratolytiske midler
- Folinsyreantagonister
- Carboplatin
- Etoposid
- Etoposid fosfat
- Paclitaxel
- Cisplatin
- Podophyllotoksin
- Immunoglobuliner
- Durvalumab
- Albumin-bundet Paclitaxel
- Antistoffer, monoklonale
- Pemetrexed
- Immunoglobulin G
Andre undersøgelses-id-numre
- NCI-2019-06124 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
- U10CA180820 (U.S. NIH-bevilling/kontrakt)
- EA5181 (Anden identifikator: CTEP)
Plan for individuelle deltagerdata (IPD)
Planlægger du at dele individuelle deltagerdata (IPD)?
JA
IPD-planbeskrivelse
NCI er forpligtet til at dele data i overensstemmelse med NIHs politik.
For flere detaljer om, hvordan kliniske forsøgsdata deles, skal du gå til linket til NIH's datadelingspolitikside.
Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter
Studerer et amerikansk FDA-reguleret lægemiddelprodukt
Ja
Studerer et amerikansk FDA-reguleret enhedsprodukt
Ingen
Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .
Kliniske forsøg med Carboplatin
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Eisai Inc.AfsluttetKræftForenede Stater, Østrig, Indien
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Samyang Biopharmaceuticals CorporationAfsluttet
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NHS Greater Glasgow and ClydeAfsluttetLivmoderhalskræft | Æggelederkræft | Primær peritoneal kræftDet Forenede Kongerige, Australien, New Zealand
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Duke UniversityAfsluttetTumorer i hjernen og centralnervesystemetForenede Stater, Canada
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National Cancer Institute (NCI)AfsluttetBrystkræft | LivmoderhalskræftForenede Stater
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Medical Research CouncilEuropean Organisation for Research and Treatment of Cancer - EORTCAfsluttetTestikulær kimcelletumorDet Forenede Kongerige, Canada, Norge, Holland, Sydafrika, Brasilien, Finland
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National Cancer Institute (NCI)Children's Oncology GroupAfsluttetTumorer i hjernen og centralnervesystemetForenede Stater, Canada, Puerto Rico, Australien, Holland, New Zealand, Schweiz
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All India Institute of Medical Sciences, New DelhiCouncil of Scientific and Industrial Research, IndiaUkendtIntraokulært retinoblastomIndien
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H. Lee Moffitt Cancer Center and Research InstituteNational Cancer Institute (NCI)AfsluttetUspecificeret fast tumor hos voksne, protokolspecifikForenede Stater
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Eli Lilly and CompanyAfsluttetLungeneoplasmerForenede Stater