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CompassHER2-pCR: Reducerende kemoterapi til brystkræftpatienter efter prækirurgiske kemoterapi og målrettet terapi

9. juli 2026 opdateret af: ECOG-ACRIN Cancer Research Group

(CompassHER2-pCR): Præoperativ THP og postoperativ HP hos patienter, der opnår en patologisk fuldstændig respons

Dette forsøg undersøger, hvor godt paclitaxel, trastuzumab og pertuzumab virker til at eliminere yderligere kemoterapi efter operation hos patienter med HER2-positiv stadium II-IIIa brystkræft, som ikke har nogen tilbageværende kræft under operationen (enten i bryst- eller underarmslymfeknuder) efter præ- operativ kemoterapi og HER2-målrettet behandling. Lægemidler, der bruges i kemoterapi, såsom paclitaxel, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. Trastuzumab og pertuzumab er begge en form for "målrettet terapi", fordi de virker ved at binde sig til specifikke molekyler (receptorer) på overfladen af tumorceller, kendt som HER2-receptorer. Når disse lægemidler binder sig til HER2-receptorer, blokeres de signaler, der fortæller cellerne at vokse, og tumorcellen kan mærkes til ødelæggelse af kroppens immunsystem. Indgivelse af paclitaxel, trastuzumab og pertuzumab kan muliggøre, at der gives færre kemoterapipræparater uden at kompromittere patientresultaterne sammenlignet med den sædvanlige behandling.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆRE MÅL:

I. For at bestemme, om 3-års recidivfri overlevelse (RFS) er større end 92 % blandt kliniske stadier II eller IIIa patienter med HER2-positiv brystkræft, som opnår patologisk komplet respons (pCR) (ypT0/er ypN0) efter præoperativ terapi med 12 uger med en taxan, trastuzumab (eller Food and Drug Administration [FDA] godkendt biosimilar) og pertuzumab (THP x 12).

SEKUNDÆRE MÅL:

I. At bestemme 3-års IDFS (invasiv sygdomsfri overlevelse), DDFS (distance sygdomsfri overlevelse), DRFS (distance recidiv-free survival), RFI (recidivfrit interval), OS (samlet overlevelse) og brystkræft -specifik overlevelse hos patienter, der opnår pCR (og ved forbehandlingens kliniske stadium). (Sekundært klinisk mål) II. At bestemme 3-års EFS (hændelsesfri overlevelse) hos alle patienter fra tidspunktet for undersøgelsesregistrering. (Sekundært klinisk mål) III. At evaluere sikkerhed og tolerabilitet for alle patienter i den præoperative fase og for patienter, der opnår pCR og deeskalerer terapi (arm A) indtil afslutningen af post-kirurgi protokol tildelt terapi (dvs. indtil slutningen af trastuzumab og pertuzumab [HP) ] terapi). (Sekundært klinisk mål) IV. At evaluere sammenhængen mellem østrogenreceptor (ER) status i den ubehandlede primære tumor med patologisk respons og med langsigtede overlevelsesresultater (herunder RFS, EFS, IDFS, DDFS, DRFS, RFI, OS og brystkræft-specifik overlevelse). (Sekundært korrelativt mål) V. At evaluere sammenhængene mellem påvisning af cirkulerende tumorceller (CTC'er) i blodet ved baseline med pCR. (Sekundært korrelativt mål) VI. For at evaluere sammenhængen mellem påvisning af CTC'er i blodet ved baseline, efter 3 ugers THP, efter 12 ugers THP (før operation), efter operation før eventuel yderligere behandling og efter afslutning af HER2-målrettet behandling med RFS hos patienter, som opnå pCR eller ej. (Sekundært korrelativt mål)

UNDERSØGENDE MÅL:

I. For at bestemme 3-års RFS, IDFS (invasiv sygdomsfri overlevelse), DDFS (distant disease-free survival), DRFS (distance recidiv-free survival), RFI (recidivfrit interval), OS (samlet overlevelse) og brystcancer-specifik overlevelse hos patienter, der ikke opnår pCR (og efter forbehandlingens kliniske stadium). (Eksplorativt klinisk mål) II. For at bestemme den patologiske respons på THP neoadjuverende terapi, som vurderet ved resterende cancerbyrde (RCB). (Eksplorativt klinisk mål) III. For at bestemme sammenhængen mellem residual cancer byrde (RCB) og alle beskrevne standardiserede definitioner for effekt-endepunkter (STEEP)-kriterieresultater. (Eksplorativt klinisk mål) IV. At bestemme den falske negative frekvens (FNR) af begrænsede stadieindgrebsprocedurer (defineret som sentinel lymfeknudebiopsi [SLNB] plus fjernelse af afklippet knude) hos patienter, der gennemgår sådanne procedurer med en planlagt aksillær lymfeknudedissektion (ALND). (Exploratory Clinical Objective) V. At bestemme aksillære pCR-hastigheder som en funktion af sygdomsbyrden ved præsentationen som bestemt på ultralyd før behandling (US) og den aksillære iscenesættelsesteknik (SLNB plus sikring af fjernelse af afklippet knude versus ALND). (Eksplorativt klinisk mål) VI. At evaluere sammenhængene mellem plasmatumorcellefri deoxyribonukleinsyre (DNA) (cfDNA) tumorspecifikke mutationer (baseline og efter terapi) med patologisk respons og langsigtede resultater (herunder RFS, EFS, IDFS, DDFS, DRFS, RFI, OS og brystkræft-specifik overlevelse). (Eksplorativt korrelativt mål) VII. At evaluere sammenhængene mellem tumorinfiltrerende lymfocytter (TIL'er) og immunaktiveringsgensignaturer i baselinetumoren med patologisk respons og langsigtede resultater (herunder RFS, EFS, IDFS, DDFS, DRFS, RFI, OS og brystkræftspecifik overlevelse) . (Eksplorativt korrelativt mål) VIII. For at bestemme hyppigheden af ændring i iboende subtype mellem præbehandling af tumorprøver og resterende sygdom på operationstidspunktet. (Eksplorativt korrelativt mål) IX. At evaluere sammenhængene mellem DNA-kopiantal, DNA-mutationer, ribonukleinsyre (RNA)-ekspression og proteinekspression i baseline-tumoren og ændringer fra baseline- til post-THP-terapi med patologisk respons og langsigtede resultater (herunder RFS, EFS, IDFS, DDFS, DRFS, RFI, OS og brystkræft-specifik overlevelse). (Udforskende korrelativt mål)

OMRIDS:

PRE-OPERATIV/NEOADJUVANT BEHANDLING: Patienter får enten paclitaxel eller nab-paclitaxel intravenøst (IV) på dag 1, 8 og 15 eller docetaxel IV på dag 1 efter den behandlende onkologs skøn. Patienterne får også trastuzumab IV på dag 1 eller dag 1, 8 og 15, og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 4 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.

KIRURGI: Inden for 42 dage efter sidste dosis neoadjuverende behandling gennemgår patienter standardbehandling lumpektomi og/eller mastektomi.

POST-OPERATIV/ADJUVANT BEHANDLING: Patienterne tildeles 1 af 2 arme.

ARM A: Patienter med pCR efter operation får trastuzumab og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 13 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også gennemgå standardbehandling strålebehandling og modtage hormonbehandling, hvis det er relevant.

ARM B: Patienter med resterende tumor efter operation får standardbehandling trastuzumab emtansin i 14 doser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også modtage yderligere standardbehandling kemoterapi, samt hormonbehandling, hvis det er relevant.

Efter afsluttet undersøgelsesbehandling følges patienterne op hver 3. måned i 2 år, hver 6. måned i 2-5 år, derefter årligt i 5-15 år fra operationsdatoen.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

2175

Fase

Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Kingman, Arizona, Forenede Stater, 86401
    - Kingman Regional Medical Center
  - Phoenix, Arizona, Forenede Stater, 85004
    - Cancer Center at Saint Joseph's
  - Tucson, Arizona, Forenede Stater, 85704
    - University of Arizona Cancer Center-Orange Grove Campus
  - Tucson, Arizona, Forenede Stater, 85719
    - Banner University Medical Center - Tucson
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center-North Campus
- Arkansas
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Hot Springs, Arkansas, Forenede Stater, 71913
    - CHI Saint Vincent Cancer Center Hot Springs
  - Jonesboro, Arkansas, Forenede Stater, 72401
    - NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
  - Little Rock, Arkansas, Forenede Stater, 72205
    - CARTI Cancer Center
- California
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Arroyo Grande, California, Forenede Stater, 93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Auburn, California, Forenede Stater, 95603
    - Sutter Cancer Centers Radiation Oncology Services-Auburn
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Burbank, California, Forenede Stater, 91505
    - Providence Saint Joseph Medical Center/Disney Family Cancer Center
  - Burlingame, California, Forenede Stater, 94010
    - Mills-Peninsula Medical Center
  - Cameron Park, California, Forenede Stater, 95682
    - Sutter Cancer Centers Radiation Oncology Services-Cameron Park
  - Cameron Park, California, Forenede Stater, 95682
    - Marshall Cancer Center
  - Carmichael, California, Forenede Stater, 95608
    - Mercy San Juan Medical Center
  - Carmichael, California, Forenede Stater, 95608
    - Mercy Cancer Center - Carmichael
  - Castro Valley, California, Forenede Stater, 94546
    - Eden Hospital Medical Center
  - Concord, California, Forenede Stater, 94520
    - John Muir Medical Center-Concord Campus
  - Davis, California, Forenede Stater, 95616
    - Sutter Davis Hospital
  - Dublin, California, Forenede Stater, 94568
    - Epic Care-Dublin
  - Elk Grove, California, Forenede Stater, 95758
    - Mercy Cancer Center - Elk Grove
  - Emeryville, California, Forenede Stater, 94608
    - Bay Area Breast Surgeons Inc
  - Emeryville, California, Forenede Stater, 94608
    - Epic Care Partners in Cancer Care
  - Fremont, California, Forenede Stater, 94538
    - Washington Hospital
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Huntington Beach, California, Forenede Stater, 92648
    - Keck Medicine of USC Huntington Beach
  - Los Angeles, California, Forenede Stater, 90033
    - USC / Norris Comprehensive Cancer Center
  - Los Angeles, California, Forenede Stater, 90033
    - Los Angeles General Medical Center
  - Martinez, California, Forenede Stater, 94553-3156
    - Contra Costa Regional Medical Center
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Camino Division
  - Mountain View, California, Forenede Stater, 94040
    - Palo Alto Medical Foundation-Gynecologic Oncology
  - Newport Beach, California, Forenede Stater, 92663
    - USC Norris Oncology/Hematology-Newport Beach
  - Novato, California, Forenede Stater, 94945
    - Sutter Cancer Research Consortium
  - Oakland, California, Forenede Stater, 94609
    - Alta Bates Summit Medical Center - Summit Campus
  - Oakland, California, Forenede Stater, 94609
    - Bay Area Tumor Institute
  - Orange, California, Forenede Stater, 92868
    - Saint Joseph Hospital - Orange
  - Palm Springs, California, Forenede Stater, 92262
    - Desert Regional Medical Center
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford Cancer Institute Palo Alto
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Pasadena, California, Forenede Stater, 91105
    - Keck Medical Center of USC Pasadena
  - Rocklin, California, Forenede Stater, 95765
    - Mercy Cancer Center - Rocklin
  - Roseville, California, Forenede Stater, 95661
    - Sutter Cancer Centers Radiation Oncology Services-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95816
    - Mercy Cancer Center - Sacramento
  - Salinas, California, Forenede Stater, 93901
    - Salinas Valley Memorial
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Francisco, California, Forenede Stater, 94110
    - Zuckerberg San Francisco General Hospital
  - San Jose, California, Forenede Stater, 95124
    - Stanford Cancer Center South Bay
  - San Luis Obispo, California, Forenede Stater, 93401
    - Pacific Central Coast Health Center-San Luis Obispo
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Maria, California, Forenede Stater, 93444
    - Mission Hope Medical Oncology - Santa Maria
  - Santa Rosa, California, Forenede Stater, 95403
    - Sutter Pacific Medical Foundation
  - St. Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Truckee, California, Forenede Stater, 96161
    - Gene Upshaw Memorial Tahoe Forest Cancer Center
  - Vacaville, California, Forenede Stater, 95687
    - Sutter Cancer Centers Radiation Oncology Services-Vacaville
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94598
    - John Muir Medical Center-Walnut Creek
  - Walnut Creek, California, Forenede Stater, 94597
    - Epic Care Cyberknife Center
  - Woodland, California, Forenede Stater, 95695
    - Woodland Memorial Hospital
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Boulder, Colorado, Forenede Stater, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Forenede Stater, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Rocky Mountain Cancer Centers-Penrose
  - Colorado Springs, Colorado, Forenede Stater, 80920
    - Memorial Hospital North
  - Colorado Springs, Colorado, Forenede Stater, 80923
    - Saint Francis Cancer Center
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80220
    - Western Surgical Care
  - Denver, Colorado, Forenede Stater, 80206
    - UCHealth - Cherry Creek
  - Durango, Colorado, Forenede Stater, 81301
    - Mercy Medical Center
  - Durango, Colorado, Forenede Stater, 81301
    - Southwest Oncology PC
  - Englewood, Colorado, Forenede Stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - The Melanoma and Skin Cancer Institute
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Cancer Care and Hematology-Fort Collins
  - Grand Junction, Colorado, Forenede Stater, 81505
    - Grand Valley Oncology
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - UCHealth Greeley Hospital
  - Highlands Ranch, Colorado, Forenede Stater, 80129
    - UCHealth Highlands Ranch Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Lone Tree, Colorado, Forenede Stater, 80124
    - UCHealth Lone Tree Health Center
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Longmont, Colorado, Forenede Stater, 80501
    - Rocky Mountain Cancer Centers-Longmont
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Loveland, Colorado, Forenede Stater, 80538
    - Medical Center of the Rockies
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06606
    - Hartford HealthCare - Saint Vincent's Medical Center
  - Derby, Connecticut, Forenede Stater, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, Forenede Stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Glastonbury, Connecticut, Forenede Stater, 06033
    - Smilow Cancer Hospital Care Center at Glastonbury
  - Greenwich, Connecticut, Forenede Stater, 06830
    - Smilow Cancer Hospital Care Center at Greenwich
  - Guilford, Connecticut, Forenede Stater, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Meriden, Connecticut, Forenede Stater, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - New Haven, Connecticut, Forenede Stater, 06510
    - Smilow Cancer Center/Yale-New Haven Hospital
  - North Haven, Connecticut, Forenede Stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Orange, Connecticut, Forenede Stater, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Stamford, Connecticut, Forenede Stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Stamford, Connecticut, Forenede Stater, 06902
    - Smilow Cancer Hospital Care Center at Long Ridge
  - Torrington, Connecticut, Forenede Stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull, Connecticut, Forenede Stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, Forenede Stater, 06385
    - Smilow Cancer Hospital Care Center - Waterford
- Delaware
  - Frankford, Delaware, Forenede Stater, 19945
    - Beebe South Coastal Health Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Seaford, Delaware, Forenede Stater, 19973
    - TidalHealth Nanticoke / Allen Cancer Center
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20002
    - Kaiser Permanente-Capitol Hill Medical Center
  - Washington D.C., District of Columbia, Forenede Stater, 20016
    - Sibley Memorial Hospital
- Florida
  - Altamonte Springs, Florida, Forenede Stater, 32701
    - AdventHealth Altamonte
  - Aventura, Florida, Forenede Stater, 33180
    - Mount Sinai Comprehensive Cancer Center at Aventura
  - Aventura, Florida, Forenede Stater, 33180
    - UM Sylvester Comprehensive Cancer Center at Aventura
  - Celebration, Florida, Forenede Stater, 34747
    - AdventHealth Celebration
  - Clearwater, Florida, Forenede Stater, 33756
    - Morton Plant Hospital
  - Coral Gables, Florida, Forenede Stater, 33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Gainesville, Florida, Forenede Stater, 32610
    - University of Florida Health Science Center - Gainesville
  - Hollywood, Florida, Forenede Stater, 33021
    - Memorial Regional Hospital/Joe DiMaggio Children's Hospital
  - Jacksonville, Florida, Forenede Stater, 32224-9980
    - Mayo Clinic in Florida
  - Kissimmee, Florida, Forenede Stater, 34744
    - AdventHealth Kissimmee
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami, Florida, Forenede Stater, 33176
    - UM Sylvester Comprehensive Cancer Center at Kendall
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Orlando
  - Orlando, Florida, Forenede Stater, 32803
    - AdventHealth Medical Group Urology at Orlando
  - Orlando, Florida, Forenede Stater, 32822
    - AdventHealth East Orlando
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - Memorial Hospital West
  - Plantation, Florida, Forenede Stater, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Safety Harbor, Florida, Forenede Stater, 34695
    - Mease Countryside Hospital
  - Winter Haven, Florida, Forenede Stater, 33881
    - Winter Haven Hospital
  - Winter Park, Florida, Forenede Stater, 32792
    - AdventHealth Winter Park
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30308
    - Emory University Hospital Midtown
  - Atlanta, Georgia, Forenede Stater, 30322
    - Emory University Hospital/Winship Cancer Institute
  - Atlanta, Georgia, Forenede Stater, 30342
    - Emory Saint Joseph's Hospital
  - Atlanta, Georgia, Forenede Stater, 30303
    - Grady Health System
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Dalton, Georgia, Forenede Stater, 30720
    - Hamilton Medical Center - Peeples Cancer Institute
  - Duluth, Georgia, Forenede Stater, 30096
    - Northside Hospital - Duluth
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - Northside Hospital - Gwinnett
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Snellville, Georgia, Forenede Stater, 30078
    - Suburban Hematology Oncology Associates - Snellville
  - Thomasville, Georgia, Forenede Stater, 31792
    - Lewis Hall Singletary Oncology Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Cancer Institute - Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Cancer Clinic
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Alton, Illinois, Forenede Stater, 62002
    - Saint Anthony's Health
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Barrington, Illinois, Forenede Stater, 60010
    - Advocate Good Shepherd Hospital
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carbondale, Illinois, Forenede Stater, 62902
    - Memorial Hospital of Carbondale
  - Carterville, Illinois, Forenede Stater, 62918
    - SIH Cancer Institute
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Centralia, Illinois, Forenede Stater, 62801
    - Saint Mary's Hospital
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - Rush University Medical Center
  - Chicago, Illinois, Forenede Stater, 60637
    - University of Chicago Comprehensive Cancer Center
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60608
    - Mount Sinai Hospital Medical Center
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Crystal Lake, Illinois, Forenede Stater, 60014
    - AMG Crystal Lake - Oncology
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - DeKalb, Illinois, Forenede Stater, 60115
    - Northwestern Medicine Cancer Center Kishwaukee
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forenede Stater, 61021
    - Illinois CancerCare-Dixon
  - Downers Grove, Illinois, Forenede Stater, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Elgin, Illinois, Forenede Stater, 60123
    - Advocate Sherman Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Western Illinois Cancer Treatment Center
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Grayslake, Illinois, Forenede Stater, 60030
    - Northwestern Medicine Grayslake Outpatient Center
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Hazel Crest, Illinois, Forenede Stater, 60429
    - Advocate South Suburban Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Joliet, Illinois, Forenede Stater, 60435
    - Duly Health and Care Joliet
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Forenede Stater, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - Condell Memorial Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - New Lenox, Illinois, Forenede Stater, 60451
    - UC Comprehensive Cancer Center at Silver Cross
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Orland Park, Illinois, Forenede Stater, 60462
    - University of Chicago Medicine-Orland Park
  - Orland Park, Illinois, Forenede Stater, 60462
    - Northwestern Medicine Orland Park
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Peru, Illinois, Forenede Stater, 61354
    - Valley Radiation Oncology
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Rockford, Illinois, Forenede Stater, 61114
    - SwedishAmerican Regional Cancer Center/ACT
  - Silvis, Illinois, Forenede Stater, 61282
    - Genesis Cancer Center - Silvis
  - Skokie, Illinois, Forenede Stater, 60076
    - North Shore Medical Center
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Swansea, Illinois, Forenede Stater, 62226
    - Southwest Illinois Health Services LLP
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington, Illinois, Forenede Stater, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Carmel, Indiana, Forenede Stater, 46032
    - IU Health North Hospital
  - Crown Point, Indiana, Forenede Stater, 46307
    - Northwest Cancer Center - Main Campus
  - Dyer, Indiana, Forenede Stater, 46311
    - Northwest Oncology LLC
  - Hobart, Indiana, Forenede Stater, 46342
    - Northwest Cancer Center - Hobart
  - Hobart, Indiana, Forenede Stater, 46342
    - Saint Mary Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Indiana University/Melvin and Bren Simon Cancer Center
  - Indianapolis, Indiana, Forenede Stater, 46219
    - Community Cancer Center East
  - Indianapolis, Indiana, Forenede Stater, 46227
    - Community Cancer Center South
  - Indianapolis, Indiana, Forenede Stater, 46256
    - Community Cancer Center North
  - Indianapolis, Indiana, Forenede Stater, 46202
    - Sidney and Lois Eskenazi Hospital
  - Indianapolis, Indiana, Forenede Stater, 46312
    - Saint Catherine Hospital
  - Kokomo, Indiana, Forenede Stater, 46904
    - Community Howard Regional Health
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Munster, Indiana, Forenede Stater, 46321
    - Women's Diagnostic Center - Munster
  - New Albany, Indiana, Forenede Stater, 47150
    - Baptist Health Floyd
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
  - Valparaiso, Indiana, Forenede Stater, 46383
    - Northwest Cancer Center - Valparaiso
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic - Ames
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic - Boone
  - Carroll, Iowa, Forenede Stater, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Alegent Health Mercy Hospital
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Davenport, Iowa, Forenede Stater, 52803
    - Genesis Medical Center - East Campus
  - Davenport, Iowa, Forenede Stater, 52804
    - Genesis Cancer Care Institute
  - Davenport, Iowa, Forenede Stater, 52807
    - Iowa Cancer Specialists
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mission Cancer and Blood - Laurel
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - Trinity Regional Medical Center
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic - Marshalltown
  - Sioux City, Iowa, Forenede Stater, 51101
    - Siouxland Regional Cancer Center
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Kansas
  - Chanute, Kansas, Forenede Stater, 66720
    - Cancer Center of Kansas - Chanute
  - Dodge City, Kansas, Forenede Stater, 67801
    - Cancer Center of Kansas - Dodge City
  - El Dorado, Kansas, Forenede Stater, 67042
    - Cancer Center of Kansas - El Dorado
  - Garden City, Kansas, Forenede Stater, 67846
    - Central Care Cancer Center - Garden City
  - Great Bend, Kansas, Forenede Stater, 67530
    - Central Care Cancer Center - Great Bend
  - Independence, Kansas, Forenede Stater, 67301
    - Cancer Center of Kansas-Independence
  - Kingman, Kansas, Forenede Stater, 67068
    - Cancer Center of Kansas-Kingman
  - Liberal, Kansas, Forenede Stater, 67905
    - Cancer Center of Kansas-Liberal
  - Manhattan, Kansas, Forenede Stater, 66502
    - Cancer Center of Kansas-Manhattan
  - McPherson, Kansas, Forenede Stater, 67460
    - Cancer Center of Kansas - McPherson
  - Newton, Kansas, Forenede Stater, 67114
    - Cancer Center of Kansas - Newton
  - Parsons, Kansas, Forenede Stater, 67357
    - Cancer Center of Kansas - Parsons
  - Pratt, Kansas, Forenede Stater, 67124
    - Cancer Center of Kansas - Pratt
  - Salina, Kansas, Forenede Stater, 67401
    - Cancer Center of Kansas - Salina
  - Wellington, Kansas, Forenede Stater, 67152
    - Cancer Center of Kansas - Wellington
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
  - Wichita, Kansas, Forenede Stater, 67208
    - Cancer Center of Kansas-Wichita Medical Arts Tower
  - Wichita, Kansas, Forenede Stater, 67214
    - Cancer Center of Kansas - Wichita
  - Winfield, Kansas, Forenede Stater, 67156
    - Cancer Center of Kansas - Winfield
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - King's Daughter's Medical Center
  - Bardstown, Kentucky, Forenede Stater, 40004
    - Flaget Memorial Hospital
  - Corbin, Kentucky, Forenede Stater, 40701
    - Baptist Health Corbin
  - Corbin, Kentucky, Forenede Stater, 40701
    - Commonwealth Cancer Center-Corbin
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Radiation Oncology Resource Center
  - Lexington, Kentucky, Forenede Stater, 40509
    - Saint Joseph Hospital East
  - Lexington, Kentucky, Forenede Stater, 40503
    - Baptist Health Lexington
  - Lexington, Kentucky, Forenede Stater, 40504
    - Saint Joseph Hospital
  - London, Kentucky, Forenede Stater, 40741
    - Saint Joseph London
  - Louisville, Kentucky, Forenede Stater, 40202
    - Jewish Hospital
  - Louisville, Kentucky, Forenede Stater, 40245
    - UofL Health Medical Center Northeast
  - Louisville, Kentucky, Forenede Stater, 40207
    - Baptist Health Louisville
  - Louisville, Kentucky, Forenede Stater, 40215
    - Saints Mary and Elizabeth Hospital
  - Madisonville, Kentucky, Forenede Stater, 42431
    - Baptist Health Madisonville/Merle Mahr Cancer Center
  - Mount Sterling, Kentucky, Forenede Stater, 40353
    - Saint Joseph Mount Sterling
  - Paducah, Kentucky, Forenede Stater, 42003
    - Baptist Health Paducah
  - Paducah, Kentucky, Forenede Stater, 42003
    - Mercy Health - Paducah Medical Oncology and Hematology
  - Shepherdsville, Kentucky, Forenede Stater, 40165
    - Jewish Hospital Medical Center South
- Louisiana
  - Covington, Louisiana, Forenede Stater, 70433
    - Ochsner Hematology Oncology North Shore - Covington (West Region)
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Medical Center Jefferson
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Forenede Stater, 71103
    - LSU Health Sciences Center at Shreveport
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Belfast, Maine, Forenede Stater, 04915
    - Waldo County General Hospital
  - Biddeford, Maine, Forenede Stater, 04005
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
  - Brewer, Maine, Forenede Stater, 04412
    - Lafayette Family Cancer Center-EMMC
  - Kennebunk, Maine, Forenede Stater, 04043
    - Maine Center for Cancer Medicine-Kennebunk
  - Rockport, Maine, Forenede Stater, 04856
    - Penobscot Bay Medical Center
  - Sanford, Maine, Forenede Stater, 04073
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Medical Center- Scarborough Campus
  - Scarborough, Maine, Forenede Stater, 04074
    - Maine Center for Cancer Medicine-Scarborough
  - South Portland, Maine, Forenede Stater, 04106
    - Maine Medical Partners - South Portland
  - Topsham, Maine, Forenede Stater, 04086
    - Maine Center for Cancer Medicine-Topsham
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - Anne Arundel Medical Center
  - Baltimore, Maryland, Forenede Stater, 21287
    - Johns Hopkins University/Sidney Kimmel Cancer Center
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Elkton, Maryland, Forenede Stater, 21921
    - Christiana Care - Union Hospital
  - Gaithersburg, Maryland, Forenede Stater, 20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Kensington, Maryland, Forenede Stater, 20895
    - Kaiser Permanente - Kensington Medical Center
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente - Largo Medical Center
  - Lutherville, Maryland, Forenede Stater, 21093
    - Kaiser Permanente Lutherville - Timonium Medical Center
  - Randallstown, Maryland, Forenede Stater, 21133
    - Northwest Hospital Center
  - Westminster, Maryland, Forenede Stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Beverly, Massachusetts, Forenede Stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forenede Stater, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, Forenede Stater, 02215
    - Dana-Farber Cancer Institute
  - Boston, Massachusetts, Forenede Stater, 02111
    - Tufts Medical Center
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Foxborough, Massachusetts, Forenede Stater, 02035
    - Dana-Farber Cancer Institute at Foxborough
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Lowell, Massachusetts, Forenede Stater, 01854
    - Lowell General Hospital
  - Methuen, Massachusetts, Forenede Stater, 01844
    - Dana Farber-Merrimack Valley
  - Milford, Massachusetts, Forenede Stater, 01757
    - Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
  - Peabody, Massachusetts, Forenede Stater, 01960
    - Lahey Medical Center-Peabody
  - South Weymouth, Massachusetts, Forenede Stater, 02190
    - Dana-Farber/Brigham and Women's Cancer Center at South Shore
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Winchester, Massachusetts, Forenede Stater, 01890
    - Winchester Hospital
  - Worcester, Massachusetts, Forenede Stater, 01655
    - UMass Memorial Medical Center - University Campus
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forenede Stater, 48116
    - University of Michigan - Brighton Center for Specialty Care
  - Detroit, Michigan, Forenede Stater, 48201
    - Wayne State University/Karmanos Cancer Institute
  - Farmington Hills, Michigan, Forenede Stater, 48334
    - Weisberg Cancer Treatment Center
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Helen DeVos Children's Hospital at Spectrum Health
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - Ascension Borgess Cancer Center
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Niles, Michigan, Forenede Stater, 49120
    - Corewell Health Lakeland Hospitals - Niles Hospital
  - Norton Shores, Michigan, Forenede Stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, Forenede Stater, 48374
    - Ascension Providence Hospitals - Novi
  - Reed City, Michigan, Forenede Stater, 49677
    - Corewell Health Reed City Hospital
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
  - Southfield, Michigan, Forenede Stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
- Minnesota
  - Aitkin, Minnesota, Forenede Stater, 56431
    - Riverwood Healthcare Center
  - Baxter, Minnesota, Forenede Stater, 56425
    - Essentia Health - Baxter Clinic
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Forenede Stater, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Deer River, Minnesota, Forenede Stater, 56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes, Minnesota, Forenede Stater, 56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Ely, Minnesota, Forenede Stater, 55731
    - Essentia Health - Ely Clinic
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston, Minnesota, Forenede Stater, 56542
    - Essentia Health - Fosston
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hibbing, Minnesota, Forenede Stater, 55746
    - Essentia Health Hibbing Clinic
  - International Falls, Minnesota, Forenede Stater, 56649
    - Essentia Health - International Falls Clinic
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Forenede Stater, 55362
    - Monticello Cancer Center
  - Moose Lake, Minnesota, Forenede Stater, 55767
    - Essentia Health - Moose Lake Clinic
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Park Rapids, Minnesota, Forenede Stater, 56470
    - Essentia Health - Park Rapids
  - Princeton, Minnesota, Forenede Stater, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Rochester, Minnesota, Forenede Stater, 55905
    - Mayo Clinic in Rochester
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Sandstone, Minnesota, Forenede Stater, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Thief River Falls, Minnesota, Forenede Stater, 56701
    - Sanford Thief River Falls Medical Center
  - Virginia, Minnesota, Forenede Stater, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Mississippi
  - Columbus, Mississippi, Forenede Stater, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Forenede Stater, 38901
    - Baptist Cancer Center-Grenada
  - Gulfport, Mississippi, Forenede Stater, 39502
    - Gulfport Memorial Hospital
  - Jackson, Mississippi, Forenede Stater, 39216
    - University of Mississippi Medical Center
  - New Albany, Mississippi, Forenede Stater, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Forenede Stater, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Pascagoula, Mississippi, Forenede Stater, 39581
    - Singing River Hospital
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Saint Louis Cancer and Breast Institute-Ballwin
  - Bolivar, Missouri, Forenede Stater, 65613
    - Central Care Cancer Center - Bolivar
  - Branson, Missouri, Forenede Stater, 65616
    - Cox Cancer Center Branson
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Saint Luke's Hospital
  - City of Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Columbia, Missouri, Forenede Stater, 65212
    - MU Health - University Hospital/Ellis Fischel Cancer Center
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Jefferson City, Missouri, Forenede Stater, 65109
    - Capital Region Southwest Campus
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Osage Beach, Missouri, Forenede Stater, 65065
    - Lake Regional Hospital
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - St Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - BJC Outpatient Center at Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Bellevue, Nebraska, Forenede Stater, 68123
    - Nebraska Medicine-Bellevue
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Kearney, Nebraska, Forenede Stater, 68847
    - CHI Health Good Samaritan
  - Lincoln, Nebraska, Forenede Stater, 68516
    - Southeast Nebraska Cancer Center - 68th Street Place
  - Lincoln, Nebraska, Forenede Stater, 68510
    - Saint Elizabeth Regional Medical Center
  - Lincoln, Nebraska, Forenede Stater, 68516
    - Cancer Partners of Nebraska - Pine Lake
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68124
    - Alegent Health Bergan Mercy Medical Center
  - Omaha, Nebraska, Forenede Stater, 68118
    - Nebraska Medicine-Village Pointe
  - Omaha, Nebraska, Forenede Stater, 68122
    - Alegent Health Immanuel Medical Center
  - Omaha, Nebraska, Forenede Stater, 68130
    - Alegent Health Lakeside Hospital
  - Omaha, Nebraska, Forenede Stater, 68131
    - Creighton University Medical Center
  - Papillion, Nebraska, Forenede Stater, 68046
    - Midlands Community Hospital
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - OptumCare Cancer Care at Seven Hills
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - GenesisCare USA - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Forenede Stater, 89074
    - Urology Specialists of Nevada - Green Valley
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89109
    - GenesisCare USA - Las Vegas
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89148
    - OptumCare Cancer Care at Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Cancer and Blood Specialists-Shadow
  - Las Vegas, Nevada, Forenede Stater, 89109
    - HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
  - Las Vegas, Nevada, Forenede Stater, 89113
    - HealthCare Partners Medical Group Oncology/Hematology-San Martin
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Cancer and Blood Specialists-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - GenesisCare USA - Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89128
    - HealthCare Partners Medical Group Oncology/Hematology-Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89148
    - GenesisCare USA - Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89149
    - HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Urology Specialists of Nevada - Southwest
  - Pahrump, Nevada, Forenede Stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Solinsky Center for Cancer Care
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Elliot Hospital
- New Jersey
  - Basking Ridge, New Jersey, Forenede Stater, 07920
    - Memorial Sloan Kettering Basking Ridge
  - Elizabeth, New Jersey, Forenede Stater, 07207
    - Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
  - Hackensack, New Jersey, Forenede Stater, 07601
    - Hackensack University Medical Center
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Jersey City, New Jersey, Forenede Stater, 07302
    - Jersey City Medical Center
  - Lakewood, New Jersey, Forenede Stater, 08701
    - Monmouth Medical Center Southern Campus
  - Livingston, New Jersey, Forenede Stater, 07039
    - Saint Barnabas Medical Center
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Middletown, New Jersey, Forenede Stater, 07748
    - Memorial Sloan Kettering Monmouth
  - Montvale, New Jersey, Forenede Stater, 07645
    - Memorial Sloan Kettering Bergen
  - Morristown, New Jersey, Forenede Stater, 07960
    - Morristown Medical Center
  - Mullica Hill, New Jersey, Forenede Stater, 08062
    - Inspira Medical Center Mullica Hill
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Newark, New Jersey, Forenede Stater, 07101
    - Rutgers New Jersey Medical School
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Sewell, New Jersey, Forenede Stater, 08080
    - Sidney Kimmel Cancer Center Washington Township
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Summit, New Jersey, Forenede Stater, 07902
    - Overlook Hospital
  - Teaneck, New Jersey, Forenede Stater, 07666
    - Holy Name Hospital
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
  - Vineland, New Jersey, Forenede Stater, 08360
    - Inspira Medical Center Vineland
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - Lovelace Medical Center-Saint Joseph Square
  - Albuquerque, New Mexico, Forenede Stater, 87110
    - Presbyterian Kaseman Hospital
  - Albuquerque, New Mexico, Forenede Stater, 87109
    - Lovelace Women's Hospital
  - Las Cruces, New Mexico, Forenede Stater, 88011
    - Memorial Medical Center - Las Cruces
  - Rio Rancho, New Mexico, Forenede Stater, 87124
    - Presbyterian Rust Medical Center/Jorgensen Cancer Center
- New York
  - Auburn, New York, Forenede Stater, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Binghamton, New York, Forenede Stater, 13905
    - Lourdes Hospital
  - Brooklyn, New York, Forenede Stater, 11219
    - Maimonides Medical Center
  - Brooklyn, New York, Forenede Stater, 11215
    - New York-Presbyterian/Brooklyn Methodist Hospital
  - Brooklyn, New York, Forenede Stater, 11234
    - Mount Sinai Brooklyn
  - Buffalo, New York, Forenede Stater, 14263
    - Roswell Park Cancer Institute
  - Commack, New York, Forenede Stater, 11725
    - Memorial Sloan Kettering Commack
  - East Hills, New York, Forenede Stater, 11548
    - Cancer Institute at Saint Francis Hospital
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - East White Plains, New York, Forenede Stater, 10604
    - Memorial Sloan Kettering Westchester
  - Flushing, New York, Forenede Stater, 11355
    - The New York Hospital Medical Center of Queens
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - Mineola, New York, Forenede Stater, 11501
    - NYU Winthrop Hospital
  - New York, New York, Forenede Stater, 10065
    - Memorial Sloan Kettering Cancer Center
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai West
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forenede Stater, 10065
    - NYP/Weill Cornell Medical Center
  - New York, New York, Forenede Stater, 10011
    - Mount Sinai Chelsea
  - New York, New York, Forenede Stater, 10016
    - Laura and Isaac Perlmutter Cancer Center at NYU Langone
  - Oswego, New York, Forenede Stater, 13126
    - Upstate Cancer Center at Oswego
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13215
    - Hematology Oncology Associates of Central New York-Onondaga Hill
  - Syracuse, New York, Forenede Stater, 13215
    - SUNY Upstate Medical Center-Community Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Uniondale, New York, Forenede Stater, 11553
    - Memorial Sloan Kettering Nassau
  - Valley Stream, New York, Forenede Stater, 11580
    - South Nassau Cancer Center
  - Verona, New York, Forenede Stater, 13478
    - Upstate Cancer Center at Verona
  - Webster, New York, Forenede Stater, 14580
    - Wilmot Cancer Institute at Webster
  - White Plains, New York, Forenede Stater, 10601
    - Dickstein Cancer Treatment Center
- North Carolina
  - Albemarle, North Carolina, Forenede Stater, 28002
    - Atrium Health Stanly/LCI-Albemarle
  - Cary, North Carolina, Forenede Stater, 27518
    - Rex Hematology Oncology Associates-Cary
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28204
    - Novant Health Presbyterian Medical Center
  - Charlotte, North Carolina, Forenede Stater, 28210
    - Atrium Health Pineville/LCI-Pineville
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Atrium Health University City/LCI-University
  - Charlotte, North Carolina, Forenede Stater, 28207
    - Novant Health Carolina Surgical - Randolph
  - Clemmons, North Carolina, Forenede Stater, 27012
    - Novant Health Colon and Rectal Clinic
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Forest City, North Carolina, Forenede Stater, 28043
    - Levine Cancer Institute - Rutherford
  - Garner, North Carolina, Forenede Stater, 27529
    - Rex Hematology Oncology Associates-Garner
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Greensboro, North Carolina, Forenede Stater, 27403
    - Novant Health Breast Surgery - Greensboro
  - Hendersonville, North Carolina, Forenede Stater, 28791
    - Margaret R Pardee Memorial Hospital
  - Hillsborough, North Carolina, Forenede Stater, 27278
    - University of North Carolina-Hillsborough Campus
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Novant Health Cancer Institute - Huntersville
  - Huntersville, North Carolina, Forenede Stater, 28078
    - Novant Health Presbyterian Medical Center Huntersville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kernersville, North Carolina, Forenede Stater, 27284
    - Novant Health Cancer Institute - Kernersville
  - Lincolnton, North Carolina, Forenede Stater, 28092
    - Atrium Health Lincoln/LCI-Lincolnton
  - Matthews, North Carolina, Forenede Stater, 28105
    - Matthews Radiation Oncology Center
  - Matthews, North Carolina, Forenede Stater, 28105
    - Novant Health Cancer Institute - Matthews
  - Matthews, North Carolina, Forenede Stater, 28104
    - Levine Cancer Institute - Union West
  - Monroe, North Carolina, Forenede Stater, 28112
    - Atrium Health Union/LCI-Union
  - Mooresville, North Carolina, Forenede Stater, 28117
    - Novant Health Cancer Institute - Mooresville
  - Mount Airy, North Carolina, Forenede Stater, 27030
    - Novant Health Cancer Institute - Mount Airy
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27607
    - UNC Rex Healthcare
  - Raleigh, North Carolina, Forenede Stater, 27614
    - UNC Rex Cancer Center of Wakefield
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Rex Hematology Oncology Associates-Blue Ridge
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Novant Health Cancer Institute - Rowan
  - Salisbury, North Carolina, Forenede Stater, 28144
    - Rowan Regional Medical Center
  - Shelby, North Carolina, Forenede Stater, 28150
    - Atrium Health Cleveland/LCI-Cleveland
  - Stateville, North Carolina, Forenede Stater, 28625
    - Novant Health Cancer Institute - Statesville
  - Thomasville, North Carolina, Forenede Stater, 27360
    - Novant Health Cancer Institute - Thomasville
  - Wilkesboro, North Carolina, Forenede Stater, 28659
    - Novant Health Cancer Institute - Wilkesboro
  - Winston-Salem, North Carolina, Forenede Stater, 27103
    - Novant Health Forsyth Medical Center
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Sanford South University Medical Center
  - Fargo, North Dakota, Forenede Stater, 58103
    - Southpointe-Sanford Medical Center Fargo
  - Fargo, North Dakota, Forenede Stater, 58104
    - Sanford Medical Center Fargo
  - Jamestown, North Dakota, Forenede Stater, 58401
    - Essentia Health - Jamestown Clinic
- Ohio
  - Alliance, Ohio, Forenede Stater, 44601
    - Aultman Alliance Community Hospital
  - Beavercreek, Ohio, Forenede Stater, 45431
    - Indu and Raj Soin Medical Center
  - Boardman, Ohio, Forenede Stater, 44512
    - Saint Elizabeth Boardman Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Cincinnati, Ohio, Forenede Stater, 45219
    - The Christ Hospital
  - Cincinnati, Ohio, Forenede Stater, 45220
    - Good Samaritan Hospital - Cincinnati
  - Cincinnati, Ohio, Forenede Stater, 45242
    - Bethesda North Hospital
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Cincinnati, Ohio, Forenede Stater, 45247
    - TriHealth Cancer Institute-Westside
  - Cincinnati, Ohio, Forenede Stater, 45255
    - TriHealth Cancer Institute-Anderson
  - Cleveland, Ohio, Forenede Stater, 44109
    - MetroHealth Medical Center
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physician LLC-Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45409
    - Dayton Blood and Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Greenville, Ohio, Forenede Stater, 45331
    - Miami Valley Cancer Care and Infusion
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Kettering, Ohio, Forenede Stater, 45420
    - First Dayton Cancer Care
  - Mansfield, Ohio, Forenede Stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Steubenville, Ohio, Forenede Stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Strongsville, Ohio, Forenede Stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Sylvania, Ohio, Forenede Stater, 43560
    - ProMedica Flower Hospital
  - Toledo, Ohio, Forenede Stater, 43606
    - ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC - Troy
  - Warren, Ohio, Forenede Stater, 44484
    - Saint Joseph Warren Hospital
  - Warrensville Heights, Ohio, Forenede Stater, 44122
    - South Pointe Hospital
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Wpafb, Ohio, Forenede Stater, 45433
    - Wright-Patterson Medical Center
  - Youngstown, Ohio, Forenede Stater, 44501
    - Saint Elizabeth Youngstown Hospital
- Oklahoma
  - Lawton, Oklahoma, Forenede Stater, 73505
    - Cancer Centers of Southwest Oklahoma Research
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Medical Center-Baker City
  - Bend, Oregon, Forenede Stater, 97701
    - Saint Charles Health System
  - Clackamas, Oregon, Forenede Stater, 97015
    - Clackamas Radiation Oncology Center
  - Clackamas, Oregon, Forenede Stater, 97015
    - Providence Cancer Institute Clackamas Clinic
  - Coos Bay, Oregon, Forenede Stater, 97420
    - Bay Area Hospital
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Medical Center-Ontario
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Redmond, Oregon, Forenede Stater, 97756
    - Saint Charles Health System-Redmond
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Altoona, Pennsylvania, Forenede Stater, 16601
    - UPMC Altoona
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forenede Stater, 16001
    - UPMC Hillman Cancer Center at Butler Health System
  - Camp Hill, Pennsylvania, Forenede Stater, 17011
    - UPMC Camp Hill
  - Carlisle, Pennsylvania, Forenede Stater, 17015
    - Carlisle Regional Cancer Center
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - WellSpan Medical Oncology and Hematology
  - Collegeville, Pennsylvania, Forenede Stater, 19426
    - Main Line Health Center-Collegeville
  - Cranberry Township, Pennsylvania, Forenede Stater, 16066
    - UPMC Hillman Cancer Center - Passavant - Cranberry
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - East Norriton, Pennsylvania, Forenede Stater, 19401
    - Fox Chase Cancer Center - East Norriton Hospital Outpatient Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Erie, Pennsylvania, Forenede Stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Erie, Pennsylvania, Forenede Stater, 16544
    - Saint Vincent Hospital
  - Exton, Pennsylvania, Forenede Stater, 19341
    - Main Line Health Center-Exton
  - Farrell, Pennsylvania, Forenede Stater, 16121
    - UPMC Cancer Center at UPMC Horizon
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Greenville, Pennsylvania, Forenede Stater, 16125
    - Oncology Hematology Associates
  - Greenville, Pennsylvania, Forenede Stater, 16125
    - UPMC Hillman Cancer Center in Greenville/UPMC Horizon
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - Cherry Tree Cancer Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Harrisburg, Pennsylvania, Forenede Stater, 17101
    - UPMC Pinnacle Harrisburg
  - Hazleton, Pennsylvania, Forenede Stater, 18201
    - Geisinger Medical Center-Cancer Center Hazleton
  - Hershey, Pennsylvania, Forenede Stater, 17033-0850
    - Penn State Milton S Hershey Medical Center
  - Indiana, Pennsylvania, Forenede Stater, 15701
    - IRMC Cancer Center
  - Jefferson Hills, Pennsylvania, Forenede Stater, 15025
    - Jefferson Hospital
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lancaster, Pennsylvania, Forenede Stater, 17601
    - Lancaster General Ann B Barshinger Cancer Institute
  - Lancaster, Pennsylvania, Forenede Stater, 17602
    - Lancaster General Hospital
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - Lewisburg, Pennsylvania, Forenede Stater, 17837
    - Geisinger Medical Oncology-Lewisburg
  - Lewistown, Pennsylvania, Forenede Stater, 17044
    - Lewistown Hospital
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Meadville, Pennsylvania, Forenede Stater, 16335
    - Yolanda G Barco Oncology Institute
  - Mechanicsburg, Pennsylvania, Forenede Stater, 17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - Forbes Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - UPMC Hillman Cancer Center - Monroeville
  - Moon Township, Pennsylvania, Forenede Stater, 15108
    - UPMC Hillman Cancer Center in Coraopolis
  - Mount Pleasant, Pennsylvania, Forenede Stater, 15666
    - UPMC Hillman Cancer Center - Part of Frick Hospital
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - UPMC Cancer Center-Natrona Heights
  - New Castle, Pennsylvania, Forenede Stater, 16105
    - UPMC Hillman Cancer Center - New Castle
  - Newtown Square, Pennsylvania, Forenede Stater, 19073
    - Bryn Mawr Health Center
  - North Huntingdon, Pennsylvania, Forenede Stater, 15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19111
    - Fox Chase Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - University of Pennsylvania/Abramson Cancer Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19148
    - Jefferson Methodist Hospital
  - Phoenixville, Pennsylvania, Forenede Stater, 19460
    - Phoenixville Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15212
    - Allegheny General Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15224
    - West Penn Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15213
    - UPMC-Magee Womens Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - Oncology Hematology Association
  - Pittsburgh, Pennsylvania, Forenede Stater, 15219
    - UPMC-Mercy Hospital
  - Pottsville, Pennsylvania, Forenede Stater, 17901
    - Geisinger Cancer Services-Pottsville
  - Reading, Pennsylvania, Forenede Stater, 19605
    - Penn State Health Saint Joseph Medical Center
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Selinsgrove, Pennsylvania, Forenede Stater, 17870
    - Geisinger Medical Oncology-Selinsgrove
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - State College, Pennsylvania, Forenede Stater, 16801
    - Geisinger Medical Group
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Uniontown Hospital Radiation Oncology
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Cancer Center-Uniontown
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Washington Hospital Radiation Oncology
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Cancer Center-Washington
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - West Mifflin, Pennsylvania, Forenede Stater, 15122
    - UPMC West Mifflin-Cancer Center Jefferson
  - West Reading, Pennsylvania, Forenede Stater, 19611
    - Reading Hospital
  - Wexford, Pennsylvania, Forenede Stater, 15090
    - Wexford Health and Wellness Pavilion
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17754
    - Divine Providence Hospital
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
  - York, Pennsylvania, Forenede Stater, 17403
    - Cancer Care Associates of York
  - York, Pennsylvania, Forenede Stater, 17408
    - UPMC Memorial
- Rhode Island
  - Providence, Rhode Island, Forenede Stater, 02905
    - Women and Infants Hospital
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent Hospital
  - Westerly, Rhode Island, Forenede Stater, 02891
    - Smilow Cancer Hospital Care Center - Westerly
- South Carolina
  - Bluffton, South Carolina, Forenede Stater, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Greenville, South Carolina, Forenede Stater, 29607
    - Saint Francis Cancer Center
  - Greenville, South Carolina, Forenede Stater, 29601
    - Saint Francis Hospital
  - Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
    - South Carolina Cancer Specialists PC
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - Levine Cancer Institute-Rock Hill
- South Dakota
  - Aberdeen, South Dakota, Forenede Stater, 57401
    - Avera Cancer Institute-Aberdeen
  - Pierre, South Dakota, Forenede Stater, 57501
    - Avera Cancer Institute at Pierre
  - Sioux Falls, South Dakota, Forenede Stater, 57105
    - Avera Cancer Institute
- Tennessee
  - Bristol, Tennessee, Forenede Stater, 37620
    - Bristol Regional Medical Center
  - Collierville, Tennessee, Forenede Stater, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Franklin, Tennessee, Forenede Stater, 37067
    - Vanderbilt-Ingram Cancer Center Cool Springs
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Ballad Health Cancer Care - Kingsport
  - Kingsport, Tennessee, Forenede Stater, 37660
    - Wellmont Holston Valley Hospital and Medical Center
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
  - Nashville, Tennessee, Forenede Stater, 37204
    - Vanderbilt Breast Center at One Hundred Oaks
- Texas
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, Forenede Stater, 75235
    - Parkland Memorial Hospital
  - Dallas, Texas, Forenede Stater, 75390
    - UT Southwestern/Simmons Cancer Center-Dallas
  - Dallas, Texas, Forenede Stater, 75237
    - UT Southwestern Simmons Cancer Center - RedBird
  - Fort Worth, Texas, Forenede Stater, 76104
    - UT Southwestern/Simmons Cancer Center-Fort Worth
  - Fort Worth, Texas, Forenede Stater, 76104
    - Tarrant County Hospital District/JPS Health Network
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
  - Houston, Texas, Forenede Stater, 77030
    - Ben Taub General Hospital
  - Laredo, Texas, Forenede Stater, 78041
    - Doctor's Hospital of Laredo
  - Richardson, Texas, Forenede Stater, 75080
    - UT Southwestern Clinical Center at Richardson/Plano
- Utah
  - Farmington, Utah, Forenede Stater, 84025
    - Farmington Health Center
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
  - Salt Lake City, Utah, Forenede Stater, 84106
    - University of Utah Sugarhouse Health Center
  - South Jordan, Utah, Forenede Stater, 84009
    - South Jordan Health Center
- Vermont
  - Saint Johnsbury, Vermont, Forenede Stater, 05819
    - Norris Cotton Cancer Center-North
- Virginia
  - Bristol, Virginia, Forenede Stater, 24201
    - Wellmont Medical Associates-Bristol
  - Burke, Virginia, Forenede Stater, 22015
    - Kaiser Permanente-Burke Medical Center
  - Chesapeake, Virginia, Forenede Stater, 23320
    - Cancer Specialists of Tidewater Limited
  - Gloucester, Virginia, Forenede Stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Martinsville, Virginia, Forenede Stater, 24115
    - Sovah Health Martinsville
  - McLean, Virginia, Forenede Stater, 22102
    - Kaiser Permanente Tysons Corner Medical Center
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian, Virginia, Forenede Stater, 23113
    - Bon Secours Westchester Emergency Center
  - Newport News, Virginia, Forenede Stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Norfolk, Virginia, Forenede Stater, 23505
    - Bon Secours DePaul Medical Center
  - Norton, Virginia, Forenede Stater, 24273
    - Southwest VA Regional Cancer Center
  - Portsmouth, Virginia, Forenede Stater, 23707
    - Bon Secours Maryview Medical Center
  - Richmond, Virginia, Forenede Stater, 23235
    - VCU Massey Cancer Center at Stony Point
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Forenede Stater, 23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - Richmond, Virginia, Forenede Stater, 23223
    - Bon Secours Richmond Community Hospital
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
  - Suffolk, Virginia, Forenede Stater, 23435
    - Cancer Specialists of Tidewater-Suffolk
  - Suffolk, Virginia, Forenede Stater, 23435
    - Bon Secours Health Center at Harbour View
  - Virginia Beach, Virginia, Forenede Stater, 23454
    - Peninsula Cancer Institute-Cancer Specialists of Tidewater
  - Williamsburg, Virginia, Forenede Stater, 23185
    - Peninsula Cancer Institute-Williamsburg
  - Woodbridge, Virginia, Forenede Stater, 22192
    - Kaiser Permanente-Caton Hill Medical Center
- Washington
  - Aberdeen, Washington, Forenede Stater, 98520
    - Providence Regional Cancer System-Aberdeen
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Medical Center
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison HealthPartners Hematology and Oncology-Bremerton
  - Bremerton, Washington, Forenede Stater, 98310
    - Harrison Medical Center
  - Burien, Washington, Forenede Stater, 98166
    - Highline Medical Center-Main Campus
  - Centralia, Washington, Forenede Stater, 98531
    - Providence Regional Cancer System-Centralia
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Enumclaw, Washington, Forenede Stater, 98022
    - Saint Elizabeth Hospital
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Cancer Partnership
  - Federal Way, Washington, Forenede Stater, 98003
    - Saint Francis Hospital
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Lacey, Washington, Forenede Stater, 98503
    - Providence Regional Cancer System-Lacey
  - Lakewood, Washington, Forenede Stater, 98499
    - Saint Clare Hospital
  - Longview, Washington, Forenede Stater, 98632
    - PeaceHealth Saint John Medical Center
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Poulsbo, Washington, Forenede Stater, 98370
    - Harrison HealthPartners Hematology and Oncology-Poulsbo
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98104
    - Pacific Gynecology Specialists
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - PeaceHealth United General Medical Center
  - Shelton, Washington, Forenede Stater, 98584
    - Providence Regional Cancer System-Shelton
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Tacoma, Washington, Forenede Stater, 98405
    - Franciscan Research Center-Northwest Medical Plaza
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98664
    - PeaceHealth Southwest Medical Center
  - Vancouver, Washington, Forenede Stater, 98684
    - Legacy Cancer Institute Medical Oncology and Day Treatment
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
  - Yelm, Washington, Forenede Stater, 98597
    - Providence Regional Cancer System-Yelm
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54911
    - ThedaCare Regional Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54915
    - Ascension Saint Elizabeth Hospital
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Duluth Clinic Ashland
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Northwest Wisconsin Cancer Center
  - Berlin, Wisconsin, Forenede Stater, 54923
    - ThedaCare Cancer Care - Berlin
  - Brookfield, Wisconsin, Forenede Stater, 53045
    - Ascension Southeast Wisconsin Hospital - Elmbrook Campus
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Chilton, Wisconsin, Forenede Stater, 53014
    - Ascension Calumet Hospital
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Cudahy, Wisconsin, Forenede Stater, 53110
    - Aurora Saint Luke's South Shore
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Eau Claire, Wisconsin, Forenede Stater, 54703
    - Mayo Clinic Health System Eau Claire Hospital-Luther Campus
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Ascension Saint Francis - Reiman Cancer Center
  - Franklin, Wisconsin, Forenede Stater, 53132
    - Ascension Southeast Wisconsin Hospital - Franklin
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Hayward, Wisconsin, Forenede Stater, 54843
    - Essentia Health-Hayward Clinic
  - Johnson Creek, Wisconsin, Forenede Stater, 53038
    - UW Cancer Center Johnson Creek
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Ladysmith, Wisconsin, Forenede Stater, 54848
    - Marshfield Clinic - Ladysmith Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Carbone Cancer Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Medford, Wisconsin, Forenede Stater, 54451
    - Aspirus Medford Hospital
  - Mequon, Wisconsin, Forenede Stater, 53097
    - Ascension Columbia Saint Mary's Hospital Ozaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53210
    - Ascension Southeast Wisconsin Hospital - Saint Joseph Campus
  - Milwaukee, Wisconsin, Forenede Stater, 53211
    - Ascension Columbia Saint Mary's Hospital - Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Ascension Saint Francis Hospital
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - Neenah, Wisconsin, Forenede Stater, 54956
    - ThedaCare Regional Medical Center - Neenah
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Ascension Mercy Hospital
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Racine, Wisconsin, Forenede Stater, 53405
    - Ascension All Saints Hospital
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ascension Saint Mary's Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Spooner, Wisconsin, Forenede Stater, 54801
    - Essentia Health-Spooner Clinic
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Superior, Wisconsin, Forenede Stater, 54880
    - Essentia Health Saint Mary's Hospital - Superior
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Waupaca, Wisconsin, Forenede Stater, 54981
    - ThedaCare Cancer Care - Waupaca
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Ascension Medical Group Southeast Wisconsin - Mayfair Road
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center
Puerto Rico
- - Bayamón, Puerto Rico, 00959-5060
    - Cancer Center-Metro Medical Center Bayamon
  - Caguas, Puerto Rico, 00726
    - HIMA San Pablo Oncologic Hospital
  - Manati, Puerto Rico, 00674
    - Doctors Cancer Center
  - Ponce, Puerto Rico, 00716
    - Instituto Oncologia Moderna Ponce
  - San Juan, Puerto Rico, 00917
    - San Juan Community Oncology Group
  - San Juan, Puerto Rico, 00927
    - Centro Comprensivo de Cancer de UPR
  - San Juan, Puerto Rico, 00936
    - San Juan City Hospital
  - San Juan, Puerto Rico, 00920
    - Primary Care Physician Group
  - San Juan, Puerto Rico, 00927
    - PROncology

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Patienter skal have en Eastern Cooperative Oncology Group (ECOG) præstationsstatus på 0 eller 1
Patienten skal have histologisk bekræftet HER2-positivt primært invasivt brystcarcinom, bestemt ved lokal test. Tumoren skal have enten HER2 IHC resultat på 3+ eller HER2/CEP17 ratio > 2 med > 4,0 HER2 signaler pr. celle ved ISH. Tumorer med HER2/CEP17 ISH-forhold < 2 er ikke kvalificerede, selvom HER2-kopinummeret er > 6, medmindre HER2 IHC-resultatet er 3+.
Patientens hormonreceptor (østrogenreceptor [ER] og progesteronreceptor [PR]) status skal være kendt og vil blive bestemt ved lokal test. Patienter med enten hormonreceptor-positiv eller hormonreceptor-negativ HER2-positiv brystkræft er kvalificerede
Patienter skal have AJCC 8. udgave trin II eller IIIa i henhold til anatomisk iscenesættelsestabel ved diagnose
- Patienter uden nodal involvering (cN0) er kvalificerede, hvis T-størrelse > 2,0 cm (T2-3)
- Patienter med nodal involvering (cN1-2) er kvalificerede, hvis T1-3
- Patienter med klinisk T4- eller N3-sygdom er ikke kvalificerede
Patienten skal være villig og i stand til (dvs. ikke have nogen kontraindikation) til at modtage standard adjuverende terapi, bestående af HER2-rettet terapi, stråling (hvis indiceret) og endokrin terapi (hvis ER+), hvis man opnår pCR ved operation
Patienter med bilateral invasiv brystkræft er berettiget, hvis begge kræftformer er HER2-positive (som defineret i 3.1.3) mindst én opfylder protokollens berettigelse, og ingen af kræftsygdomme gør patienten ukvalificeret (dvs. pr. berettigelse 3.1.5)
Patienter med flere ipsilaterale invasive tumorer er berettigede, så længe alle tumorer er HER2-positive, og mindst ét tumorfokus opfylder berettigelseskriterierne (pr. berettigelse 3.1.5). Flere læsioner, der forekommer som en del af samme indekstumor, kræver ikke yderligere biopsi/HER2-test. Flere læsioner, der forekommer som en del af samme indekstumor, kræver ikke yderligere biopsi/HER2-test. Men selvom biopsi ikke anses for nødvendig, bør det overvejes at placere et klip i enhver læsion, der er 1 cm eller længere fra den primære tumor for at sikre, at al tumor fjernes ved operationen OG at patologen kan lokalisere alle primære steder af tumor for at vurdere patologisk respons ved operation.
Patienter med en anamnese med andre ikke-brystmaligniteter er kvalificerede, hvis de har været sygdomsfrie i mindst 5 år og vurderes af investigator at have lav risiko for gentagelse af denne malignitet.
- Patienter med følgende kræftformer er berettigede, hvis de er diagnosticeret og behandlet inden for de seneste 5 år: livmoderhalskræft in situ, basalcelle- eller pladecellekarcinom i huden og lokaliseret papillær eller follikulær skjoldbruskkirtelkræft, som har afsluttet den anbefalede behandling inklusive kirurgi. Patienter med andre kræftformer inden for de sidste 5 år er ikke berettigede.
Patenter skal have en venstre ventrikulær ejektionsfraktion (LVEF) inden for normale institutionelle parametre (eller > 50 %)
Patienter må ikke have > grad 1 perifer neuropati af nogen ætiologi.
Patienterne skal have et bilateralt mammografi og en diagnostisk brystultralyd [på siden af kræften/kræfterne] (med eller uden bryst-MR) udført ved screeningen. En aksillær ultralyd på siden af cancer(erne) er også påkrævet. Men hvis en patient har en negativ aksillær fysisk undersøgelse og en baseline MR uden mistænkelige lymfeknuder udført før aksillær ultralyd, kan aksillær ultralyd udelades. Omfattende bryst- og aksillær billeddannelse skal udføres inden for 42 dage efter registreringen (dvs. patientens mammografi/bryst-ultralyd/aksillære ultralyd ELLER deres bryst-MR).
Baseline-billeddannelse af den ipsilaterale aksill ved ultralyd eller bryst-MR er obligatorisk. For forsøgspersoner med aksillære lymfeknuder, der er mistænkelige ved klinisk undersøgelse eller billeddannelse, skal patienten være villig til at få foretaget en nålespiration eller kernebiopsi for at bestemme tilstedeværelsen af metastatisk sygdom i lymfeknuderne. Et klip skal placeres i den involverede aksillære lymfeknude. (Hvis der er mere end 1 mistænkelige aksillære noder, kræves der kun én afklippet node).
Patienter i den fødedygtige alder og seksuelt aktive patienter skal anvende accepterede og effektive præventionsmetode(r) eller afholde sig fra samleje i hele deres deltagelse i undersøgelsen og i 7 måneder efter den sidste dosis af undersøgelsesbehandlingen.
Patienten skal være villig og i stand til at underskrive informeret samtykke
Leukocytter >= 3.000/mcL (opnået =< 28 dage før protokolregistrering)
Absolut neutrofiltal >= 1.500/mcL (opnået =< 28 dage før protokolregistrering)
Blodplader >= 100.000/mcL (opnået =< 28 dage før protokolregistrering)
Total bilirubin =< 1,5 x institutionel øvre normalgrænse (ULN) (opnået =< 28 dage før protokolregistrering)
Aspartataminotransferase (AST) (serumglutamin-oxaloeddikesyretransaminase [SGOT])/alaninaminotransferase (ALT) (serumglutamatpyruvattransaminase [SGPT]) =< 2,5 x institutionel ULN (opnået =< 28 dage før protokolregistrering)
Kreatinin =< 1,5 x institutionel ULN (opnået =< 28 dage før protokolregistrering)
Humant immundefektvirus (HIV)-inficerede patienter i effektiv antiretroviral behandling med upåviselig viral belastning inden for 6 måneder er kvalificerede til dette forsøg
For patienter med tegn på kronisk hepatitis B-virus (HBV)-infektion, skal HBV-virusmængden være uopdagelig ved suppressiv behandling, hvis indiceret
Patienter med en historie med hepatitis C-virus (HCV)-infektion skal være blevet behandlet og helbredt. For patienter med HCV-infektion, som i øjeblikket er i behandling, er de berettigede, hvis de har en upåviselig HCV-virusbelastning

Ekskluderingskriterier:

Patienter må ikke have nedsat beslutningsevne
Patienten må ikke have en historie med nogen tidligere (ipsilateral eller kontralateral) invasiv brystkræft
- En undtagelse: en patient med en historie med T1N0 triple negativ brystkræft diagnosticeret mere end 10 år tidligere, som forbliver sygdomsfri, er berettiget
Patienten må ikke have tidligere ipsilateralt duktalt brystcarcinom in situ (DCIS). Patienter med tidligere lobular brystcarcinom in situ (LCIS), atypisk hyperplasi, andre højrisiko benigne læsioner eller kontralateral DCIS (uden tegn på mikroinvasion) er kvalificerede
- BEMÆRK: Patienter, der i øjeblikket modtager endokrin behandling for tidligere kontralateral DCIS, er kvalificerede
Patienten må ikke have stadium IV (metastatisk) brystkræft
- Stadiestudier (computertomografi [CT] bryst/mave/bækken og en knoglescanning eller positronemissionstomografi [PET]-CT-scanning) er påkrævet for stadium III sygdom eller dem med unormale baseline leverfunktionstests (LFT'er), symptomer (f.eks. nye knoglesmerter) eller unormale fysiske undersøgelsesresultater (National Comprehensive Cancer Network [NCCN] retningslinjer version [V]1.2019)
Patienten må ikke have T4 og/eller N3 sygdom, herunder inflammatorisk brystkræft
Patienten må ikke have nogen forudgående behandling for den aktuelle brystkræft, herunder kirurgi, kemoterapi, hormonbehandling, stråling eller eksperimentel terapi
Patienter må ikke have > grad 1 perifer neuropati af nogen ætiologi
Patienten må ikke have en samtidig alvorlig medicinsk tilstand, der vil udelukke færdiggørelse af studieterapi. For eksempel ukontrolleret hypertension (systolisk > 180 mm Hg og/eller diastolisk > 100 mm Hg) eller klinisk signifikant (dvs. aktiv) kardiovaskulær sygdom: cerebrovaskulær ulykke/slagtilfælde eller myokardieinfarkt inden for 6 måneder før registrering, ustabil angina, kongestiv hjertesvigt (CHF) eller alvorlig hjertearytmi, der kræver medicin og andre samtidige alvorlige sygdomme, der kan interferere med planlagt behandling
Patienten må ikke være gravid eller ammende på grund af den potentielle skade på et ufødt foster og mulig risiko for bivirkninger hos ammende spædbørn med de behandlingsregimer, der anvendes. Patienter må heller ikke forvente at blive gravide fra registreringstidspunktet, mens de er i undersøgelsesbehandling, og indtil mindst 7 måneder efter den sidste dosis af undersøgelsesbehandlingen. Alle patienter i den fødedygtige alder skal have en blodprøve eller urinundersøgelse inden for 14 dage før registrering for at udelukke graviditet
- Alle patienter i den fødedygtige alder er enhver, uanset seksuel orientering eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) har opnået menarche på et tidspunkt, 2) har ikke gennemgået en hysterektomi eller bilateral ooforektomi; eller 3) ikke har været naturligt postmenopausal i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Ikke-randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Arm A (pCR efter operation) PRE-OPERATIV/NEOADJUVANT BEHANDLING: Patienter får enten paclitaxel eller nab-paclitaxel IV på dag 1, 8 og 15 eller docetaxel IV på dag 1 efter den behandlende onkologs skøn. Patienterne får også trastuzumab IV på dag 1 eller dag 1, 8 og 15, og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 4 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. KIRURGI: Inden for 42 dage efter sidste dosis neoadjuverende behandling gennemgår patienter standardbehandling lumpektomi og/eller mastektomi. POST-OPERATIV.ADJUVANT BEHANDLING: Patienter med pCR efter operation får trastuzumab og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 13 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også gennemgå standardbehandling strålebehandling og modtage hormonbehandling, hvis det er relevant.	Biologisk: Trastuzumab Givet IV Andre navne: Herceptin ABP 980 ALT02 Anti-c-ERB-2 Anti-c-erbB2 monoklonalt antistof Anti-ERB-2 Anti-erbB-2 Anti-erbB2 monoklonalt antistof Anti-HER2/c-erbB2 monoklonalt antistof Anti-p185-HER2 c-erb-2 monoklonalt antistof HER2 monoklonalt antistof Herceptin Biosimilar PF-05280014 Herceptin Trastuzumab Biosimilar PF-05280014 Herzuma MoAb HER2 Monoklonalt antistof c-erb-2 Monoklonalt antistof HER2 Ogivri Ontruzant PF-05280014 rhuMAb HER2 RO0452317 SB3 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar ALT02 trastuzumab biosimilar EG12014 Trastuzumab Biosimilar HLX02 Trastuzumab Biosimilar PF-05280014 Trastuzumab Biosimilar SB3 Trastuzumab-dkst Trastuzumab-dttb Trastuzumab-pkrb Trastuzumab-QYYP Trazimera Medicin: Nab-paclitaxel Givet IV Andre navne: ABI-007 Abraxane Albumin-bundet Paclitaxel ABI 007 Albumin-stabiliseret nanopartikel Paclitaxel Nanopartikel Albumin-bundet Paclitaxel Nanopartikel Paclitaxel Paclitaxel Albumin paclitaxel albumin-stabiliseret nanopartikelformulering proteinbundet paclitaxel Medicin: Paclitaxel Givet IV Andre navne: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Medicin: Docetaxel Givet IV Andre navne: Taxotere Docecad RP56976 Taxotere injektionskoncentrat Stråling: Stråleterapi Gennemgå strålebehandling Andre navne: Kræftstrålebehandling Bestråle Stråleterapi, NOS Radioterapeutika Strålebehandling RT Terapi, Stråling bestråling STRÅLING bestrålet Biologisk: Pertuzumab Givet IV Andre navne: Perjeta 2C4 2C4 antistof MoAb 2C4 Monoklonalt antistof 2C4 Omnitarg rhuMAb2C4 RO4368451 Procedure: Lumpektomi Gennemgå lumpektomi Andre navne: Lumpektomi af bryst Delvis mastektomi Procedure: Mastektomi Gennemgå mastektomi Andre navne: Mammektomi
Eksperimentel: Arm B (resterende invasiv sygdom efter operation) PRE-OPERATIV/NEOADJUVANT BEHANDLING: Patienter får enten paclitaxel eller nab-paclitaxel IV på dag 1, 8 og 15 eller docetaxel IV på dag 1 efter den behandlende onkologs skøn. Patienterne får også trastuzumab IV på dag 1 eller dag 1, 8 og 15, og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 4 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. KIRURGI: Inden for 42 dage efter sidste dosis neoadjuverende behandling gennemgår patienter standardbehandling lumpektomi og/eller mastektomi. POST-OPERATIV/ADJUVANT BEHANDLING: Patienter med resterende tumor efter operation får standardbehandling trastuzumab emtansin i 14 doser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også modtage yderligere standardbehandling kemoterapi, samt hormonbehandling, hvis det er relevant.	Biologisk: Trastuzumab Givet IV Andre navne: Herceptin ABP 980 ALT02 Anti-c-ERB-2 Anti-c-erbB2 monoklonalt antistof Anti-ERB-2 Anti-erbB-2 Anti-erbB2 monoklonalt antistof Anti-HER2/c-erbB2 monoklonalt antistof Anti-p185-HER2 c-erb-2 monoklonalt antistof HER2 monoklonalt antistof Herceptin Biosimilar PF-05280014 Herceptin Trastuzumab Biosimilar PF-05280014 Herzuma MoAb HER2 Monoklonalt antistof c-erb-2 Monoklonalt antistof HER2 Ogivri Ontruzant PF-05280014 rhuMAb HER2 RO0452317 SB3 Trastuzumab Biosimilar ABP 980 Trastuzumab Biosimilar ALT02 trastuzumab biosimilar EG12014 Trastuzumab Biosimilar HLX02 Trastuzumab Biosimilar PF-05280014 Trastuzumab Biosimilar SB3 Trastuzumab-dkst Trastuzumab-dttb Trastuzumab-pkrb Trastuzumab-QYYP Trazimera Medicin: Nab-paclitaxel Givet IV Andre navne: ABI-007 Abraxane Albumin-bundet Paclitaxel ABI 007 Albumin-stabiliseret nanopartikel Paclitaxel Nanopartikel Albumin-bundet Paclitaxel Nanopartikel Paclitaxel Paclitaxel Albumin paclitaxel albumin-stabiliseret nanopartikelformulering proteinbundet paclitaxel Medicin: Paclitaxel Givet IV Andre navne: Taxol Anzatax Asotax Bristaxol Praxel Taxol Konzentrat Medicin: Docetaxel Givet IV Andre navne: Taxotere Docecad RP56976 Taxotere injektionskoncentrat Biologisk: Pertuzumab Givet IV Andre navne: Perjeta 2C4 2C4 antistof MoAb 2C4 Monoklonalt antistof 2C4 Omnitarg rhuMAb2C4 RO4368451 Biologisk: Trastuzumab Emtansine Givet IV Andre navne: RO5304020 Kadcyla Ado Trastuzumab Emtansine ADO-Trastuzumab Emtansine PRO132365 T-DM1 Trastuzumab-DM1 Trastuzumab-MCC-DM1 Trastuzumab-MCC-DM1 antistof-lægemiddelkonjugat Trastuzumab-MCC-DM1 immunkonjugat Procedure: Lumpektomi Gennemgå lumpektomi Andre navne: Lumpektomi af bryst Delvis mastektomi Procedure: Mastektomi Gennemgå mastektomi Andre navne: Mammektomi

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Arm A (pCR efter operation)

PRE-OPERATIV/NEOADJUVANT BEHANDLING: Patienter får enten paclitaxel eller nab-paclitaxel IV på dag 1, 8 og 15 eller docetaxel IV på dag 1 efter den behandlende onkologs skøn. Patienterne får også trastuzumab IV på dag 1 eller dag 1, 8 og 15, og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 4 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.

KIRURGI: Inden for 42 dage efter sidste dosis neoadjuverende behandling gennemgår patienter standardbehandling lumpektomi og/eller mastektomi.

POST-OPERATIV.ADJUVANT BEHANDLING: Patienter med pCR efter operation får trastuzumab og pertuzumab IV på dag 1. Behandlingen gentages hver 21. dag i op til 13 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også gennemgå standardbehandling strålebehandling og modtage hormonbehandling, hvis det er relevant.

Biologisk: Trastuzumab

Givet IV

Andre navne:

Herceptin
ABP 980
ALT02
Anti-c-ERB-2
Anti-c-erbB2 monoklonalt antistof
Anti-ERB-2
Anti-erbB-2
Anti-erbB2 monoklonalt antistof
Anti-HER2/c-erbB2 monoklonalt antistof
Anti-p185-HER2
c-erb-2 monoklonalt antistof
HER2 monoklonalt antistof
Herceptin Biosimilar PF-05280014
Herceptin Trastuzumab Biosimilar PF-05280014
Herzuma
MoAb HER2
Monoklonalt antistof c-erb-2
Monoklonalt antistof HER2
Ogivri
Ontruzant
PF-05280014
rhuMAb HER2
RO0452317
SB3
Trastuzumab Biosimilar ABP 980
Trastuzumab Biosimilar ALT02
trastuzumab biosimilar EG12014
Trastuzumab Biosimilar HLX02
Trastuzumab Biosimilar PF-05280014
Trastuzumab Biosimilar SB3
Trastuzumab-dkst
Trastuzumab-dttb
Trastuzumab-pkrb
Trastuzumab-QYYP
Trazimera

Medicin: Nab-paclitaxel

Givet IV

Andre navne:

ABI-007
Abraxane
Albumin-bundet Paclitaxel
ABI 007
Albumin-stabiliseret nanopartikel Paclitaxel
Nanopartikel Albumin-bundet Paclitaxel
Nanopartikel Paclitaxel
Paclitaxel Albumin
paclitaxel albumin-stabiliseret nanopartikelformulering
proteinbundet paclitaxel

Medicin: Paclitaxel

Givet IV

Andre navne:

Taxol
Anzatax
Asotax
Bristaxol
Praxel
Taxol Konzentrat

Medicin: Docetaxel

Givet IV

Andre navne:

Taxotere
Docecad
RP56976
Taxotere injektionskoncentrat

Stråling: Stråleterapi

Gennemgå strålebehandling

Andre navne:

Kræftstrålebehandling
Bestråle
Stråleterapi, NOS
Radioterapeutika
Strålebehandling
RT
Terapi, Stråling
bestråling
STRÅLING
bestrålet

Biologisk: Pertuzumab

Givet IV

Andre navne:

Perjeta
2C4
2C4 antistof
MoAb 2C4
Monoklonalt antistof 2C4
Omnitarg
rhuMAb2C4
RO4368451

Procedure: Lumpektomi

Gennemgå lumpektomi

Andre navne:

Lumpektomi af bryst
Delvis mastektomi

Procedure: Mastektomi

Gennemgå mastektomi

Andre navne:

Mammektomi

Eksperimentel: Arm B (resterende invasiv sygdom efter operation)

KIRURGI: Inden for 42 dage efter sidste dosis neoadjuverende behandling gennemgår patienter standardbehandling lumpektomi og/eller mastektomi.

POST-OPERATIV/ADJUVANT BEHANDLING: Patienter med resterende tumor efter operation får standardbehandling trastuzumab emtansin i 14 doser i fravær af sygdomsprogression eller uacceptabel toksicitet. Patienter kan også modtage yderligere standardbehandling kemoterapi, samt hormonbehandling, hvis det er relevant.

Biologisk: Trastuzumab

Givet IV

Andre navne:

Herceptin
ABP 980
ALT02
Anti-c-ERB-2
Anti-c-erbB2 monoklonalt antistof
Anti-ERB-2
Anti-erbB-2
Anti-erbB2 monoklonalt antistof
Anti-HER2/c-erbB2 monoklonalt antistof
Anti-p185-HER2
c-erb-2 monoklonalt antistof
HER2 monoklonalt antistof
Herceptin Biosimilar PF-05280014
Herceptin Trastuzumab Biosimilar PF-05280014
Herzuma
MoAb HER2
Monoklonalt antistof c-erb-2
Monoklonalt antistof HER2
Ogivri
Ontruzant
PF-05280014
rhuMAb HER2
RO0452317
SB3
Trastuzumab Biosimilar ABP 980
Trastuzumab Biosimilar ALT02
trastuzumab biosimilar EG12014
Trastuzumab Biosimilar HLX02
Trastuzumab Biosimilar PF-05280014
Trastuzumab Biosimilar SB3
Trastuzumab-dkst
Trastuzumab-dttb
Trastuzumab-pkrb
Trastuzumab-QYYP
Trazimera

Medicin: Nab-paclitaxel

Givet IV

Andre navne:

ABI-007
Abraxane
Albumin-bundet Paclitaxel
ABI 007
Albumin-stabiliseret nanopartikel Paclitaxel
Nanopartikel Albumin-bundet Paclitaxel
Nanopartikel Paclitaxel
Paclitaxel Albumin
paclitaxel albumin-stabiliseret nanopartikelformulering
proteinbundet paclitaxel

Medicin: Paclitaxel

Givet IV

Andre navne:

Taxol
Anzatax
Asotax
Bristaxol
Praxel
Taxol Konzentrat

Medicin: Docetaxel

Givet IV

Andre navne:

Taxotere
Docecad
RP56976
Taxotere injektionskoncentrat

Biologisk: Pertuzumab

Givet IV

Andre navne:

Perjeta
2C4
2C4 antistof
MoAb 2C4
Monoklonalt antistof 2C4
Omnitarg
rhuMAb2C4
RO4368451

Biologisk: Trastuzumab Emtansine

Givet IV

Andre navne:

RO5304020
Kadcyla
Ado Trastuzumab Emtansine
ADO-Trastuzumab Emtansine
PRO132365
T-DM1
Trastuzumab-DM1
Trastuzumab-MCC-DM1
Trastuzumab-MCC-DM1 antistof-lægemiddelkonjugat
Trastuzumab-MCC-DM1 immunkonjugat

Procedure: Lumpektomi

Gennemgå lumpektomi

Andre navne:

Lumpektomi af bryst
Delvis mastektomi

Procedure: Mastektomi

Gennemgå mastektomi

Andre navne:

Mammektomi

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Gentagelsesfri overlevelse (RFS) Tidsramme: Op til 3 år efter endt behandling	Hændelser omfatter recidiv af ipsilateral invasiv brysttumor, recidiv af lokoregional invasiv brysttumor og fjernt recidiv. Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og østrogenreceptor (ER) status. Greenwood-metoden vil blive brugt til at estimere 95% konfidensintervallet for 3-års rate.	Op til 3 år efter endt behandling

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Invasiv sygdomsfri overlevelse (IDFS) Tidsramme: Op til 3 år efter endt behandling	Hændelser omfatter recidiv af ipsilateral invasiv brysttumor, recidiv af lokoregional invasiv brysttumor, fjerntilbagefald, kontralateral invasiv brystkræft og anden primær ikke-bryst-invasiv cancer (bortset fra pladecelle- eller basalcellehudkræft). Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og ER-status. Analysen vil være beskrivende, og der vil ikke være nogen statistisk test.	Op til 3 år efter endt behandling
Fjern sygdomsfri overlevelse (DDFS) Tidsramme: Op til 3 år efter endt behandling	Hændelser omfatter fjernt tilbagefald og anden primær ikke-bryst-invasiv cancer (bortset fra pladecelle- eller basalcellehudkræft). Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og ER-status. Analysen vil være beskrivende, og der vil ikke være nogen statistisk test.	Op til 3 år efter endt behandling
Fjerntilbagefaldsfri overlevelse (DRFS) Tidsramme: U til 3 år efter endt behandling	Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og ER-status. Analysen vil være beskrivende, og der vil ikke være nogen statistisk test.	U til 3 år efter endt behandling
Gentagelsesfrit interval (RFI) Tidsramme: Op til 3 år efter endt behandling	Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og ER-status. Analysen vil være beskrivende, og der vil ikke være nogen statistisk test.	Op til 3 år efter endt behandling
Samlet overlevelse (OS) Tidsramme: Fra operationsdatoen til dødsdatoen uanset årsag, vurderet op til 3 år efter endt behandling	Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og ER-status. Analysen vil være beskrivende, og der vil ikke være nogen statistisk test.	Fra operationsdatoen til dødsdatoen uanset årsag, vurderet op til 3 år efter endt behandling
Begivenhedsfri overlevelse (EFS) Tidsramme: Op til 3 år efter endt behandling	Overlevelseskurve estimeret ved hjælp af Kaplan-Meier-metoden i den samlede analysepopulation og ved forbehandlingens kliniske stadium og ER-status. Analysen vil være beskrivende, og der vil ikke være nogen statistisk test.	Op til 3 år efter endt behandling
Forekomst af bivirkninger (AE'er) Tidsramme: Op til 1 uge efter cyklus 4 (alle patienter) og/eller op til cyklus 13 efter operationen (kun arm A) (hver cyklus er 21 dage)	Vil blive bedømt ved at bruge National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0. Alle behandlingsudløste og baseline bivirkninger og hæmatologiske/biokemiske toksiciteter baseret på laboratoriemålinger, såvel som lægemiddelrelaterede bivirkninger, vil blive opsummeret af NCI CTCAE v5.0 værste grad. Hyppigheden af dødsfald og behandlingsfremkaldte alvorlige uønskede hændelser (defineret som antallet af patienter, der oplever AE divideret med alle behandlede patienter) vil blive opsummeret ved brug af binomale proportioner og binomiale nøjagtige 95 % konfidensintervaller. Hyppigheden af uønskede hændelser, der fører til seponering af protokolbehandling, vil også blive opsummeret og listet.	Op til 1 uge efter cyklus 4 (alle patienter) og/eller op til cyklus 13 efter operationen (kun arm A) (hver cyklus er 21 dage)

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

ECOG-ACRIN Cancer Research Group

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Ledende efterforsker: Nadine M Tung, ECOG-ACRIN Cancer Research Group

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

13. marts 2020

Primær færdiggørelse (Anslået)

31. oktober 2027

Studieafslutning (Anslået)

31. december 2038

Datoer for studieregistrering

Først indsendt

7. februar 2020

Først indsendt, der opfyldte QC-kriterier

11. februar 2020

Først opslået (Faktiske)

12. februar 2020

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

10. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

9. juli 2026

Sidst verificeret

1. juli 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

EA1181 (Anden identifikator: CTEP)
U10CA180820 (U.S. NIH-bevilling/kontrakt)
NCI-2019-07439 (Registry Identifier: CTRP (Clinical Trial Reporting Program))

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ingen

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

CompassHER2-pCR: Reducerende kemoterapi til brystkræftpatienter efter prækirurgiske kemoterapi og målrettet terapi

(CompassHER2-pCR): Præoperativ THP og postoperativ HP hos patienter, der opnår en patologisk fuldstændig respons

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Anslået)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

produkt fremstillet i og eksporteret fra U.S.A.