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EA2176: Fase 3 klinisk forsøg med Carboplatin og Paclitaxel +/- Nivolumab hos patienter med metastatisk analcancer

28. maj 2026 opdateret af: National Cancer Institute (NCI)

Et randomiseret fase III-studie af immunkontrolpunkthæmning med kemoterapi hos behandlings-nave metastaserende analcancerpatienter

Dette fase 3-forsøg sammenligner tilføjelsen af ​​nivolumab til kemoterapi (carboplatin og paclitaxel) versus sædvanlig behandling (kemoterapi alene) til behandling af analkræft, der har spredt sig til andre steder i kroppen (metastatisk). Immunterapi med monoklonale antistoffer, såsom nivolumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig. Kemoterapimedicin, såsom carboplatin og paclitaxel, virker på forskellige måder for at stoppe væksten af ​​tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. At give nivolumab sammen med carboplatin og paclitaxel kan hjælpe lægerne med at finde ud af, om behandlingen er bedre eller den samme som den sædvanlige tilgang.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. At demonstrere, at anti-PD-1-terapi i kombination med carboplatin/ugentlig paclitaxel resulterer i forbedret progressionsfri overlevelse (PFS) versus systemisk kemoterapi alene.

SEKUNDÆRE MÅL:

I. At demonstrere, at anti-PD-1-terapi i kombination med carboplatin/ugentlig paclitaxel resulterer i forbedret overordnet overlevelse (OS) versus systemisk kemoterapi alene.

II. At demonstrere, at anti-PD-1-terapi i kombination med carboplatin/ugentlig paclitaxel resulterer i forbedret objektiv respons ved brug af responsevalueringskriterier i solide tumorer (RECIST) version (v)1.1 versus systemisk kemoterapi alene.

III. At evaluere toksicitetsprofiler for de to regimer.

OVERSIGT: Patienterne randomiseres til 1 af 2 arme. Randomisering vil være 2:1 til fordel for forsøgsregimet, Arm B.

ARM A: Patienterne får paclitaxel intravenøst ​​(IV) på dag 1, 8 og 15 i hver cyklus og carboplatin IV på dag 1 i hver cyklus. Behandlingen gentages hver 28. dag i op til 6 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.

ARM B: Patienterne får nivolumab IV over 30 minutter på dag 1 og 15 i cyklus 1 og derefter kun på dag 1 i efterfølgende cyklusser, paclitaxel IV på dag 1, 8 og 15 i hver cyklus og carboplatin på dag 1 i hver cyklus. . Behandlingen gentages hver 28. dag i op til 6 cyklusser for carboplatin og paclitaxel og op til 2 år for nivolumab i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienterne op efter 1 måned, derefter hver 3. måned i 2 år.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

205

Fase

  • Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

  • Forenede Stater
    • Alaska
      • Anchorage, Alaska, Forenede Stater, 98508
        • Anchorage Associates in Radiation Medicine
      • Anchorage, Alaska, Forenede Stater, 99508
        • Alaska Breast Care and Surgery LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Alaska Oncology and Hematology LLC
      • Anchorage, Alaska, Forenede Stater, 99508
        • Alaska Women's Cancer Care
      • Anchorage, Alaska, Forenede Stater, 99508
        • Anchorage Oncology Centre
      • Anchorage, Alaska, Forenede Stater, 99508
        • Katmai Oncology Group
      • Anchorage, Alaska, Forenede Stater, 99508
        • Providence Alaska Medical Center
      • Anchorage, Alaska, Forenede Stater, 99504
        • Anchorage Radiation Therapy Center
    • Arizona
      • Kingman, Arizona, Forenede Stater, 86401
        • Kingman Regional Medical Center
      • Phoenix, Arizona, Forenede Stater, 85004
        • Cancer Center at Saint Joseph's
    • Arkansas
      • Fort Smith, Arkansas, Forenede Stater, 72903
        • Mercy Hospital Fort Smith
      • Hot Springs, Arkansas, Forenede Stater, 71913
        • CHI Saint Vincent Cancer Center Hot Springs
    • California
      • Anaheim, California, Forenede Stater, 92806
        • Kaiser Permanente-Anaheim
      • Antioch, California, Forenede Stater, 94531
        • Kaiser Permanente-Deer Valley Medical Center
      • Arroyo Grande, California, Forenede Stater, 93420
        • PCR Oncology
      • Arroyo Grande, California, Forenede Stater, 93420
        • Mission Hope Medical Oncology - Arroyo Grande
      • Baldwin Park, California, Forenede Stater, 91706
        • Kaiser Permanente-Baldwin Park
      • Bellflower, California, Forenede Stater, 90706
        • Kaiser Permanente-Bellflower
      • Burbank, California, Forenede Stater, 91505
        • Providence Saint Joseph Medical Center/Disney Family Cancer Center
      • Dublin, California, Forenede Stater, 94568
        • Kaiser Permanente Dublin
      • Fontana, California, Forenede Stater, 92335
        • Kaiser Permanente-Fontana
      • Fremont, California, Forenede Stater, 94538
        • Kaiser Permanente-Fremont
      • Fresno, California, Forenede Stater, 93720
        • Kaiser Permanente-Fresno
      • Fresno, California, Forenede Stater, 93720
        • Fresno Cancer Center
      • Harbor City, California, Forenede Stater, 90710
        • Kaiser Permanente South Bay
      • Irvine, California, Forenede Stater, 92618
        • Kaiser Permanente-Irvine
      • Los Angeles, California, Forenede Stater, 90033
        • USC / Norris Comprehensive Cancer Center
      • Los Angeles, California, Forenede Stater, 90048
        • Cedars-Sinai Medical Center
      • Los Angeles, California, Forenede Stater, 90027
        • Kaiser Permanente Los Angeles Medical Center
      • Los Angeles, California, Forenede Stater, 90034
        • Kaiser Permanente West Los Angeles
      • Los Angeles, California, Forenede Stater, 90020
        • Keck Medicine of USC Koreatown
      • Los Angeles, California, Forenede Stater, 90033
        • Los Angeles General Medical Center
      • Modesto, California, Forenede Stater, 95356
        • Kaiser Permanente-Modesto
      • Newport Beach, California, Forenede Stater, 92663
        • USC Norris Oncology/Hematology-Newport Beach
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente-Oakland
      • Oakland, California, Forenede Stater, 94611
        • Kaiser Permanente Oakland-Broadway
      • Ontario, California, Forenede Stater, 91761
        • Kaiser Permanente-Ontario
      • Orange, California, Forenede Stater, 92868
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
      • Panorama City, California, Forenede Stater, 91402
        • Kaiser Permanente - Panorama City
      • Rancho Cordova, California, Forenede Stater, 95670
        • Kaiser Permanente-Rancho Cordova Cancer Center
      • Redwood City, California, Forenede Stater, 94063
        • Kaiser Permanente-Redwood City
      • Richmond, California, Forenede Stater, 94801
        • Kaiser Permanente-Richmond
      • Riverside, California, Forenede Stater, 92505
        • Kaiser Permanente-Riverside
      • Rohnert Park, California, Forenede Stater, 94928
        • Rohnert Park Cancer Center
      • Roseville, California, Forenede Stater, 95678
        • The Permanente Medical Group-Roseville Radiation Oncology
      • Roseville, California, Forenede Stater, 95661
        • Kaiser Permanente-Roseville
      • Sacramento, California, Forenede Stater, 95814
        • Kaiser Permanente Downtown Commons
      • Sacramento, California, Forenede Stater, 95823
        • Kaiser Permanente-South Sacramento
      • Sacramento, California, Forenede Stater, 95823
        • South Sacramento Cancer Center
      • San Diego, California, Forenede Stater, 92120
        • Kaiser Permanente-San Diego Zion
      • San Diego, California, Forenede Stater, 92108
        • Kaiser Permanente-San Diego Mission
      • San Francisco, California, Forenede Stater, 94115
        • Kaiser Permanente-San Francisco
      • San Jose, California, Forenede Stater, 95119
        • Kaiser Permanente-Santa Teresa-San Jose
      • San Leandro, California, Forenede Stater, 94577
        • Kaiser Permanente San Leandro
      • San Luis Obispo, California, Forenede Stater, 93401
        • Pacific Central Coast Health Center-San Luis Obispo
      • San Marcos, California, Forenede Stater, 92078
        • Kaiser Permanente-San Marcos
      • San Rafael, California, Forenede Stater, 94903
        • Kaiser San Rafael-Gallinas
      • Santa Clara, California, Forenede Stater, 95051
        • Kaiser Permanente Medical Center - Santa Clara
      • Santa Maria, California, Forenede Stater, 93444
        • Mission Hope Medical Oncology - Santa Maria
      • Santa Rosa, California, Forenede Stater, 95403
        • Kaiser Permanente-Santa Rosa
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente Cancer Treatment Center
      • South San Francisco, California, Forenede Stater, 94080
        • Kaiser Permanente-South San Francisco
      • Stockton, California, Forenede Stater, 95210
        • Kaiser Permanente-Stockton
      • Torrance, California, Forenede Stater, 90509
        • Torrance Memorial Medical Center
      • Torrance, California, Forenede Stater, 90505
        • Torrance Memorial Physician Network - Cancer Care
      • Vacaville, California, Forenede Stater, 95688
        • Kaiser Permanente Medical Center-Vacaville
      • Vallejo, California, Forenede Stater, 94589
        • Kaiser Permanente-Vallejo
      • Walnut Creek, California, Forenede Stater, 94596
        • Kaiser Permanente-Walnut Creek
      • Woodland Hills, California, Forenede Stater, 91367
        • Kaiser Permanente-Woodland Hills
    • Colorado
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Penrose-Saint Francis Healthcare
      • Colorado Springs, Colorado, Forenede Stater, 80907
        • Rocky Mountain Cancer Centers-Penrose
      • Denver, Colorado, Forenede Stater, 80210
        • AdventHealth Porter
      • Durango, Colorado, Forenede Stater, 81301
        • Mercy Medical Center
      • Durango, Colorado, Forenede Stater, 81301
        • CommonSpirit Cancer Center Mercy
      • Lakewood, Colorado, Forenede Stater, 80228
        • CommonSpirit Saint Anthony Hospital Cancer Center
      • Littleton, Colorado, Forenede Stater, 80122
        • AdventHealth Littleton
      • Longmont, Colorado, Forenede Stater, 80501
        • Longmont United Hospital
      • Longmont, Colorado, Forenede Stater, 80501
        • Rocky Mountain Cancer Centers-Longmont
      • Parker, Colorado, Forenede Stater, 80138
        • AdventHealth Parker
      • Pueblo, Colorado, Forenede Stater, 81004
        • Saint Mary Corwin Medical Center
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Beebe Medical Center
      • Millville, Delaware, Forenede Stater, 19967
        • Beebe South Coastal Health Campus
      • Newark, Delaware, Forenede Stater, 19713
        • Helen F Graham Cancer Center
      • Newark, Delaware, Forenede Stater, 19713
        • Delaware Clinical and Laboratory Physicians PA
      • Newark, Delaware, Forenede Stater, 19713
        • Medical Oncology Hematology Consultants PA
      • Newark, Delaware, Forenede Stater, 19718
        • Christiana Care Health System-Christiana Hospital
      • Rehoboth Beach, Delaware, Forenede Stater, 19971
        • Beebe Health Campus
      • Seaford, Delaware, Forenede Stater, 19973
        • TidalHealth Nanticoke / Allen Cancer Center
      • Wilmington, Delaware, Forenede Stater, 19801
        • Christiana Care Health System-Wilmington Hospital
    • Florida
      • Altamonte Springs, Florida, Forenede Stater, 32701
        • AdventHealth Altamonte
      • Celebration, Florida, Forenede Stater, 34747
        • AdventHealth Celebration
      • Fort Lauderdale, Florida, Forenede Stater, 33308
        • Holy Cross Hospital
      • Kissimmee, Florida, Forenede Stater, 34744
        • AdventHealth Kissimmee
      • Orlando, Florida, Forenede Stater, 32803
        • AdventHealth Orlando
      • Orlando, Florida, Forenede Stater, 32803
        • AdventHealth Medical Group Urology at Orlando
      • Orlando, Florida, Forenede Stater, 32822
        • AdventHealth East Orlando
      • Pensacola, Florida, Forenede Stater, 32504
        • Sacred Heart Hospital
      • Tampa, Florida, Forenede Stater, 33606
        • Tampa General Hospital
      • Winter Park, Florida, Forenede Stater, 32792
        • AdventHealth Winter Park
    • Georgia
      • Thomasville, Georgia, Forenede Stater, 31792
        • Lewis Hall Singletary Oncology Center
    • Hawaii
      • Honolulu, Hawaii, Forenede Stater, 96819
        • Kaiser Permanente Moanalua Medical Center
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Saint Alphonsus Cancer Care Center-Boise
      • Boise, Idaho, Forenede Stater, 83712
        • Saint Luke's Cancer Institute - Boise
      • Caldwell, Idaho, Forenede Stater, 83605
        • Saint Alphonsus Cancer Care Center-Caldwell
      • Coeur d'Alene, Idaho, Forenede Stater, 83814
        • Kootenai Health - Coeur d'Alene
      • Emmett, Idaho, Forenede Stater, 83617
        • Walter Knox Memorial Hospital
      • Fruitland, Idaho, Forenede Stater, 83619
        • Saint Luke's Cancer Institute - Fruitland
      • Meridian, Idaho, Forenede Stater, 83642
        • Idaho Urologic Institute-Meridian
      • Meridian, Idaho, Forenede Stater, 83642
        • Saint Luke's Cancer Institute - Meridian
      • Nampa, Idaho, Forenede Stater, 83687
        • Saint Alphonsus Cancer Care Center-Nampa
      • Nampa, Idaho, Forenede Stater, 83687
        • Saint Luke's Cancer Institute - Nampa
      • Post Falls, Idaho, Forenede Stater, 83854
        • Kootenai Clinic Cancer Services - Post Falls
      • Sandpoint, Idaho, Forenede Stater, 83864
        • Kootenai Clinic Cancer Services - Sandpoint
      • Twin Falls, Idaho, Forenede Stater, 83301
        • Saint Luke's Cancer Institute - Twin Falls
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • OSF Saint Anthony's Health Center
      • Aurora, Illinois, Forenede Stater, 60504
        • Rush-Copley Medical Center
      • Bloomington, Illinois, Forenede Stater, 61704
        • Illinois CancerCare-Bloomington
      • Canton, Illinois, Forenede Stater, 61520
        • Illinois CancerCare-Canton
      • Carbondale, Illinois, Forenede Stater, 62902
        • Memorial Hospital of Carbondale
      • Carterville, Illinois, Forenede Stater, 62918
        • SIH Cancer Institute
      • Carthage, Illinois, Forenede Stater, 62321
        • Illinois CancerCare-Carthage
      • Centralia, Illinois, Forenede Stater, 62801
        • Centralia Oncology Clinic
      • Chicago, Illinois, Forenede Stater, 60611
        • Northwestern University
      • Chicago, Illinois, Forenede Stater, 60612
        • University of Illinois
      • Chicago, Illinois, Forenede Stater, 60612
        • Rush MD Anderson Cancer Center
      • Danville, Illinois, Forenede Stater, 61832
        • Carle at The Riverfront
      • DeKalb, Illinois, Forenede Stater, 60115
        • Northwestern Medicine Cancer Center Kishwaukee
      • Decatur, Illinois, Forenede Stater, 62526
        • Decatur Memorial Hospital
      • Decatur, Illinois, Forenede Stater, 62526
        • Cancer Care Specialists of Illinois - Decatur
      • Dixon, Illinois, Forenede Stater, 61021
        • Illinois CancerCare-Dixon
      • Effingham, Illinois, Forenede Stater, 62401
        • Crossroads Cancer Center
      • Effingham, Illinois, Forenede Stater, 62401
        • Carle Physician Group-Effingham
      • Eureka, Illinois, Forenede Stater, 61530
        • Illinois CancerCare-Eureka
      • Galesburg, Illinois, Forenede Stater, 61401
        • Western Illinois Cancer Treatment Center
      • Galesburg, Illinois, Forenede Stater, 61401
        • Illinois CancerCare-Galesburg
      • Geneva, Illinois, Forenede Stater, 60134
        • Northwestern Medicine Cancer Center Delnor
      • Glenview, Illinois, Forenede Stater, 60026
        • Northwestern Medicine Glenview Outpatient Center
      • Grayslake, Illinois, Forenede Stater, 60030
        • Northwestern Medicine Grayslake Outpatient Center
      • Harvey, Illinois, Forenede Stater, 60426
        • Ingalls Memorial Hospital
      • Kewanee, Illinois, Forenede Stater, 61443
        • Illinois CancerCare-Kewanee Clinic
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Northwestern Medicine Lake Forest Hospital
      • Macomb, Illinois, Forenede Stater, 61455
        • Illinois CancerCare-Macomb
      • Mattoon, Illinois, Forenede Stater, 61938
        • Carle Physician Group-Mattoon/Charleston
      • Mount Vernon, Illinois, Forenede Stater, 62864
        • SSM Health Good Samaritan
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Cancer Care Center of O'Fallon
      • Orland Park, Illinois, Forenede Stater, 60462
        • Northwestern Medicine Orland Park
      • Ottawa, Illinois, Forenede Stater, 61350
        • Illinois CancerCare-Ottawa Clinic
      • Pekin, Illinois, Forenede Stater, 61554
        • Illinois CancerCare-Pekin
      • Peoria, Illinois, Forenede Stater, 61636
        • Methodist Medical Center of Illinois
      • Peoria, Illinois, Forenede Stater, 61615
        • Illinois CancerCare-Peoria
      • Peru, Illinois, Forenede Stater, 61354
        • Illinois CancerCare-Peru
      • Peru, Illinois, Forenede Stater, 61354
        • Valley Radiation Oncology
      • Princeton, Illinois, Forenede Stater, 61356
        • Illinois CancerCare-Princeton
      • Springfield, Illinois, Forenede Stater, 62702
        • Southern Illinois University School of Medicine
      • Springfield, Illinois, Forenede Stater, 62702
        • Springfield Clinic
      • Springfield, Illinois, Forenede Stater, 62781
        • Springfield Memorial Hospital
      • Swansea, Illinois, Forenede Stater, 62226
        • Southwest Illinois Health Services LLP
      • Urbana, Illinois, Forenede Stater, 61801
        • Carle Cancer Center
      • Urbana, Illinois, Forenede Stater, 61801
        • The Carle Foundation Hospital
      • Warrenville, Illinois, Forenede Stater, 60555
        • Northwestern Medicine Cancer Center Warrenville
      • Washington, Illinois, Forenede Stater, 61571
        • Illinois CancerCare - Washington
      • Yorkville, Illinois, Forenede Stater, 60560
        • Rush-Copley Healthcare Center
    • Indiana
      • Richmond, Indiana, Forenede Stater, 47374
        • Reid Health
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • Mary Greeley Medical Center
      • Ames, Iowa, Forenede Stater, 50010
        • McFarland Clinic - Ames
      • Ankeny, Iowa, Forenede Stater, 50023
        • UI Health Care Mission Cancer and Blood - Ankeny Clinic
      • Boone, Iowa, Forenede Stater, 50036
        • McFarland Clinic - Boone
      • Carroll, Iowa, Forenede Stater, 51401
        • Saint Anthony Regional Hospital
      • Clive, Iowa, Forenede Stater, 50325
        • Mercy Cancer Center-West Lakes
      • Clive, Iowa, Forenede Stater, 50325
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
      • Council Bluffs, Iowa, Forenede Stater, 51503
        • Alegent Health Mercy Hospital
      • Creston, Iowa, Forenede Stater, 50801
        • Greater Regional Medical Center
      • Des Moines, Iowa, Forenede Stater, 50309
        • Iowa Methodist Medical Center
      • Des Moines, Iowa, Forenede Stater, 50314
        • Mercy Medical Center - Des Moines
      • Des Moines, Iowa, Forenede Stater, 50314
        • Broadlawns Medical Center
      • Des Moines, Iowa, Forenede Stater, 50316
        • Iowa Lutheran Hospital
      • Des Moines, Iowa, Forenede Stater, 50309
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
      • Des Moines, Iowa, Forenede Stater, 50314
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • McFarland Clinic - Trinity Cancer Center
      • Fort Dodge, Iowa, Forenede Stater, 50501
        • UI Healthcare Mission Cancer and Blood - Fort Dodge
      • Jefferson, Iowa, Forenede Stater, 50129
        • McFarland Clinic - Jefferson
      • Marshalltown, Iowa, Forenede Stater, 50158
        • McFarland Clinic - Marshalltown
      • West Des Moines, Iowa, Forenede Stater, 50266-7700
        • Methodist West Hospital
      • West Des Moines, Iowa, Forenede Stater, 50266
        • Mercy Medical Center-West Lakes
    • Kansas
      • Garden City, Kansas, Forenede Stater, 67846
        • Central Care Cancer Center - Garden City
      • Great Bend, Kansas, Forenede Stater, 67530
        • Central Care Cancer Center - Great Bend
    • Kentucky
      • Bardstown, Kentucky, Forenede Stater, 40004
        • Flaget Memorial Hospital
      • Corbin, Kentucky, Forenede Stater, 40701
        • Commonwealth Cancer Center-Corbin
      • Lexington, Kentucky, Forenede Stater, 40504
        • Saint Joseph Radiation Oncology Resource Center
      • Lexington, Kentucky, Forenede Stater, 40509
        • Saint Joseph Hospital East
      • London, Kentucky, Forenede Stater, 40741
        • Saint Joseph London
      • Louisville, Kentucky, Forenede Stater, 40202
        • Jewish Hospital
      • Louisville, Kentucky, Forenede Stater, 40245
        • UofL Health Medical Center Northeast
      • Louisville, Kentucky, Forenede Stater, 40215
        • Saints Mary and Elizabeth Hospital
      • Shepherdsville, Kentucky, Forenede Stater, 40165
        • Jewish Hospital Medical Center South
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70805
        • LSU Health Baton Rouge-North Clinic
      • Baton Rouge, Louisiana, Forenede Stater, 70808
        • Our Lady of the Lake Physician Group
      • New Orleans, Louisiana, Forenede Stater, 70112
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Louisiana State University Health Science Center
    • Massachusetts
      • Worcester, Massachusetts, Forenede Stater, 01655
        • UMass Memorial Medical Center - University Campus
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • University of Michigan Rogel Cancer Center
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
      • Battle Creek, Michigan, Forenede Stater, 49017
        • Bronson Battle Creek
      • Brighton, Michigan, Forenede Stater, 48114
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
      • Brighton, Michigan, Forenede Stater, 48114
        • Trinity Health Medical Center - Brighton
      • Canton, Michigan, Forenede Stater, 48188
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
      • Canton, Michigan, Forenede Stater, 48188
        • Trinity Health Medical Center - Canton
      • Caro, Michigan, Forenede Stater, 48723
        • Caro Cancer Center
      • Chelsea, Michigan, Forenede Stater, 48118
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
      • Chelsea, Michigan, Forenede Stater, 48118
        • Chelsea Hospital
      • Clarkston, Michigan, Forenede Stater, 48346
        • Hematology Oncology Consultants-Clarkston
      • Clarkston, Michigan, Forenede Stater, 48346
        • Newland Medical Associates-Clarkston
      • Detroit, Michigan, Forenede Stater, 48201
        • Wayne State University/Karmanos Cancer Institute
      • Detroit, Michigan, Forenede Stater, 48236
        • Henry Ford Health Saint John Hospital
      • East China Township, Michigan, Forenede Stater, 48054
        • Henry Ford River District Hospital
      • Farmington Hills, Michigan, Forenede Stater, 48334
        • Weisberg Cancer Treatment Center
      • Flint, Michigan, Forenede Stater, 48503
        • Hurley Medical Center
      • Flint, Michigan, Forenede Stater, 48503
        • Genesee Hematology Oncology PC
      • Flint, Michigan, Forenede Stater, 48503
        • Genesys Hurley Cancer Institute
      • Flint, Michigan, Forenede Stater, 48503
        • Cancer Hematology Centers - Flint
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Trinity Health Grand Rapids Hospital
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Corewell Health Grand Rapids Hospitals - Butterworth Hospital
      • Grand Rapids, Michigan, Forenede Stater, 49503
        • Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Henry Ford Saint John Hospital - Academic
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Henry Ford Saint John Hospital - Breast
      • Grosse Pointe Woods, Michigan, Forenede Stater, 48236
        • Henry Ford Saint John Hospital - Van Elslander
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • West Michigan Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49007
        • Bronson Methodist Hospital
      • Kalamazoo, Michigan, Forenede Stater, 49009
        • Beacon Kalamazoo Cancer Center
      • Kalamazoo, Michigan, Forenede Stater, 49048
        • Beacon Kalamazoo
      • Lansing, Michigan, Forenede Stater, 48910
        • Karmanos Cancer Institute at McLaren Greater Lansing
      • Lansing, Michigan, Forenede Stater, 48912
        • University of Michigan Health - Sparrow Lansing
      • Livonia, Michigan, Forenede Stater, 48154
        • Trinity Health Saint Mary Mercy Livonia Hospital
      • Livonia, Michigan, Forenede Stater, 48154
        • Hope Cancer Clinic
      • Macomb, Michigan, Forenede Stater, 48044
        • Henry Ford Warren Hospital - Breast Macomb
      • Macomb, Michigan, Forenede Stater, 48044
        • Henry Ford Saint John Hospital - Macomb Medical
      • Marlette, Michigan, Forenede Stater, 48453
        • Saint Mary's Oncology/Hematology Associates of Marlette
      • Muskegon, Michigan, Forenede Stater, 49444
        • Trinity Health Muskegon Hospital
      • Niles, Michigan, Forenede Stater, 49120
        • Corewell Health Lakeland Hospitals - Niles Hospital
      • Norton Shores, Michigan, Forenede Stater, 49444
        • Cancer and Hematology Centers of Western Michigan - Norton Shores
      • Novi, Michigan, Forenede Stater, 48374
        • Henry Ford Health Providence Novi Hospital
      • Pontiac, Michigan, Forenede Stater, 48341
        • Hope Cancer Center
      • Pontiac, Michigan, Forenede Stater, 48341
        • Newland Medical Associates-Pontiac
      • Pontiac, Michigan, Forenede Stater, 48341
        • Trinity Health Saint Joseph Mercy Oakland Hospital
      • Pontiac, Michigan, Forenede Stater, 48341
        • Michigan Healthcare Professionals Pontiac
      • Reed City, Michigan, Forenede Stater, 49677
        • Corewell Health Reed City Hospital
      • Rochester Hills, Michigan, Forenede Stater, 48309
        • Henry Ford Rochester Hospital
      • Saginaw, Michigan, Forenede Stater, 48604
        • Oncology Hematology Associates of Saginaw Valley PC
      • Saginaw, Michigan, Forenede Stater, 48601
        • MyMichigan Medical Center Saginaw
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
      • Saint Joseph, Michigan, Forenede Stater, 49085
        • Corewell Health Lakeland Hospitals - Saint Joseph Hospital
      • Southfield, Michigan, Forenede Stater, 48075
        • Henry Ford Health Providence Southfield Hospital
      • Sterling Heights, Michigan, Forenede Stater, 48312
        • Bhadresh Nayak MD PC-Sterling Heights
      • Tawas City, Michigan, Forenede Stater, 48764
        • MyMichigan Medical Center Tawas
      • Traverse City, Michigan, Forenede Stater, 49684
        • Munson Medical Center
      • Warren, Michigan, Forenede Stater, 48088
        • Advanced Breast Care Center PLLC
      • Warren, Michigan, Forenede Stater, 48093
        • Macomb Hematology Oncology PC
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Madison Heights Hospital - Breast
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Health Warren Hospital
      • Warren, Michigan, Forenede Stater, 48093
        • Henry Ford Warren Hospital - GLCMS
      • West Branch, Michigan, Forenede Stater, 48661
        • Saint Mary's Oncology/Hematology Associates of West Branch
      • Wyoming, Michigan, Forenede Stater, 49519
        • University of Michigan Health - West
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
      • Ypsilanti, Michigan, Forenede Stater, 48106
        • Huron Gastroenterology PC
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
        • Sanford Joe Lueken Cancer Center
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Fairview Ridges Hospital
      • Burnsville, Minnesota, Forenede Stater, 55337
        • Minnesota Oncology - Burnsville
      • Cambridge, Minnesota, Forenede Stater, 55008
        • Cambridge Medical Center
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Mercy Hospital
      • Edina, Minnesota, Forenede Stater, 55435
        • Fairview Southdale Hospital
      • Fridley, Minnesota, Forenede Stater, 55432
        • Unity Hospital
      • Maple Grove, Minnesota, Forenede Stater, 55369
        • Fairview Clinics and Surgery Center Maple Grove
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Saint John's Hospital - Healtheast
      • Maplewood, Minnesota, Forenede Stater, 55109
        • Minnesota Oncology Hematology PA-Maplewood
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Hennepin County Medical Center
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Abbott-Northwestern Hospital
      • Minneapolis, Minnesota, Forenede Stater, 55454
        • Health Partners Inc
      • Monticello, Minnesota, Forenede Stater, 55362
        • Monticello Cancer Center
      • New Ulm, Minnesota, Forenede Stater, 56073
        • New Ulm Medical Center
      • Princeton, Minnesota, Forenede Stater, 55371
        • Fairview Northland Medical Center
      • Robbinsdale, Minnesota, Forenede Stater, 55422
        • North Memorial Medical Health Center
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Park Nicollet Clinic - Saint Louis Park
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Regions Hospital
      • Saint Paul, Minnesota, Forenede Stater, 55102
        • United Hospital
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Saint Francis Regional Medical Center
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Lakeview Hospital
      • Thief River Falls, Minnesota, Forenede Stater, 56701
        • Sanford Thief River Falls Medical Center
      • Waconia, Minnesota, Forenede Stater, 55387
        • Ridgeview Medical Center
      • Willmar, Minnesota, Forenede Stater, 56201
        • Rice Memorial Hospital
      • Woodbury, Minnesota, Forenede Stater, 55125
        • Minnesota Oncology Hematology PA-Woodbury
      • Worthington, Minnesota, Forenede Stater, 56187
        • Sanford Cancer Center Worthington
      • Wyoming, Minnesota, Forenede Stater, 55092
        • Fairview Lakes Medical Center
    • Missouri
      • Ballwin, Missouri, Forenede Stater, 63011
        • Mercy Oncology and Hematology - Clayton-Clarkson
      • Bolivar, Missouri, Forenede Stater, 65613
        • Central Care Cancer Center - Bolivar
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Saint Francis Medical Center
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Mercy Cancer Center - Cape Girardeau
      • Chesterfield, Missouri, Forenede Stater, 63017
        • Saint Luke's Hospital
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Siteman Cancer Center at Saint Peters Hospital
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Siteman Cancer Center at West County Hospital
      • Farmington, Missouri, Forenede Stater, 63640
        • Parkland Health Center - Farmington
      • Jefferson City, Missouri, Forenede Stater, 65109
        • MU Health Care Goldschmidt Cancer Center
      • Joplin, Missouri, Forenede Stater, 64804
        • Freeman Health System
      • Joplin, Missouri, Forenede Stater, 64804
        • Mercy Hospital Joplin
      • Rolla, Missouri, Forenede Stater, 65401
        • Mercy Clinic-Rolla-Cancer and Hematology
      • Rolla, Missouri, Forenede Stater, 65401
        • Phelps Health Delbert Day Cancer Institute
      • Saint Joseph, Missouri, Forenede Stater, 64506
        • Heartland Regional Medical Center
      • Sainte Genevieve, Missouri, Forenede Stater, 63670
        • Sainte Genevieve County Memorial Hospital
      • Springfield, Missouri, Forenede Stater, 65807
        • CoxHealth South Hospital
      • Springfield, Missouri, Forenede Stater, 65804
        • Mercy Hospital Springfield
      • St Louis, Missouri, Forenede Stater, 63110
        • Washington University School of Medicine
      • St Louis, Missouri, Forenede Stater, 63129
        • Siteman Cancer Center-South County
      • St Louis, Missouri, Forenede Stater, 63136
        • Siteman Cancer Center at Christian Hospital
      • St Louis, Missouri, Forenede Stater, 63131
        • Missouri Baptist Medical Center
      • St Louis, Missouri, Forenede Stater, 63109
        • Mercy Infusion Center - Chippewa
      • St Louis, Missouri, Forenede Stater, 63141
        • Mercy Hospital Saint Louis
      • St Louis, Missouri, Forenede Stater, 63128
        • Mercy Hospital South
      • Sullivan, Missouri, Forenede Stater, 63080
        • Missouri Baptist Sullivan Hospital
      • Sunset Hills, Missouri, Forenede Stater, 63127
        • BJC Outpatient Center at Sunset Hills
      • Washington, Missouri, Forenede Stater, 63090
        • Mercy Hospital Washington
    • Montana
      • Anaconda, Montana, Forenede Stater, 59711
        • Community Hospital of Anaconda
      • Billings, Montana, Forenede Stater, 59101
        • Billings Clinic Cancer Center
      • Bozeman, Montana, Forenede Stater, 59715
        • Bozeman Health Deaconess Hospital
      • Great Falls, Montana, Forenede Stater, 59405
        • Great Falls Clinic
      • Great Falls, Montana, Forenede Stater, 59405
        • Benefis Sletten Cancer Institute
      • Kalispell, Montana, Forenede Stater, 59901
        • Logan Health Medical Center
      • Missoula, Montana, Forenede Stater, 59802
        • Saint Patrick Hospital - Community Hospital
      • Missoula, Montana, Forenede Stater, 59804
        • Community Medical Center
    • Nebraska
      • Bellevue, Nebraska, Forenede Stater, 68123
        • Nebraska Medicine-Bellevue
      • Grand Island, Nebraska, Forenede Stater, 68803
        • Nebraska Cancer Specialists/Oncology Hematology West PC
      • Kearney, Nebraska, Forenede Stater, 68847
        • CHI Health Good Samaritan
      • Lincoln, Nebraska, Forenede Stater, 68510
        • Saint Elizabeth Regional Medical Center
      • Omaha, Nebraska, Forenede Stater, 68198
        • University of Nebraska Medical Center
      • Omaha, Nebraska, Forenede Stater, 68124
        • Alegent Health Bergan Mercy Medical Center
      • Omaha, Nebraska, Forenede Stater, 68118
        • Nebraska Medicine-Village Pointe
      • Omaha, Nebraska, Forenede Stater, 68122
        • Alegent Health Immanuel Medical Center
      • Omaha, Nebraska, Forenede Stater, 68130
        • Alegent Health Lakeside Hospital
      • Omaha, Nebraska, Forenede Stater, 68131
        • Creighton University Medical Center
      • Papillion, Nebraska, Forenede Stater, 68046
        • Midlands Community Hospital
    • Nevada
      • Carson City, Nevada, Forenede Stater, 89703
        • Carson Tahoe Regional Medical Center
      • Henderson, Nevada, Forenede Stater, 89052
        • Comprehensive Cancer Centers of Nevada - Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Cancer and Blood Specialists-Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Las Vegas Cancer Center-Henderson
      • Henderson, Nevada, Forenede Stater, 89074
        • Comprehensive Cancer Centers of Nevada-Southeast Henderson
      • Henderson, Nevada, Forenede Stater, 89052
        • Comprehensive Cancer Centers of Nevada-Horizon Ridge
      • Henderson, Nevada, Forenede Stater, 89074
        • Las Vegas Urology - Green Valley
      • Henderson, Nevada, Forenede Stater, 89074
        • Las Vegas Urology - Pebble
      • Henderson, Nevada, Forenede Stater, 89074
        • Urology Specialists of Nevada - Green Valley
      • Henderson, Nevada, Forenede Stater, 89074
        • Oncology Las Vegas - Henderson
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Summerlin Hospital Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89109
        • Sunrise Hospital and Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89102
        • OptumCare Cancer Care at Charleston
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Radiation Oncology Centers of Nevada Central
      • Las Vegas, Nevada, Forenede Stater, 89119
        • Radiation Oncology Centers of Nevada Southeast
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Comprehensive Cancer Centers of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89128
        • OptumCare Cancer Care at MountainView
      • Las Vegas, Nevada, Forenede Stater, 89135
        • Alliance for Childhood Diseases/Cure 4 the Kids Foundation
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Comprehensive Cancer Centers of Nevada - Town Center
      • Las Vegas, Nevada, Forenede Stater, 89144
        • Comprehensive Cancer Centers of Nevada-Summerlin
      • Las Vegas, Nevada, Forenede Stater, 89148
        • Comprehensive Cancer Centers of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89169
        • Comprehensive Cancer Centers of Nevada - Central Valley
      • Las Vegas, Nevada, Forenede Stater, 89102
        • University Medical Center of Southern Nevada
      • Las Vegas, Nevada, Forenede Stater, 89148-2405
        • Las Vegas Cancer Center-Medical Center
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Ann M Wierman MD LTD
      • Las Vegas, Nevada, Forenede Stater, 89074
        • Las Vegas Urology - Pecos
      • Las Vegas, Nevada, Forenede Stater, 89102
        • Desert West Surgery
      • Las Vegas, Nevada, Forenede Stater, 89103
        • Hope Cancer Care of Nevada
      • Las Vegas, Nevada, Forenede Stater, 89106
        • Urology Specialists of Nevada - Central
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Las Vegas Prostate Cancer Center
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Las Vegas Urology - Sunset
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Las Vegas Urology - Cathedral Rock
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Las Vegas Urology - Smoke Ranch
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Urology Specialists of Nevada - Northwest
      • Las Vegas, Nevada, Forenede Stater, 89169
        • University Cancer Center
      • Las Vegas, Nevada, Forenede Stater, 89113
        • Urology Specialists of Nevada - Southwest
      • Las Vegas, Nevada, Forenede Stater, 89128
        • Oncology Las Vegas - Tenaya
      • Las Vegas, Nevada, Forenede Stater, 89183
        • OptumCare Cancer Care at Fort Apache
      • Pahrump, Nevada, Forenede Stater, 89048
        • Hope Cancer Care of Nevada-Pahrump
      • Reno, Nevada, Forenede Stater, 89502
        • Renown Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89503
        • Saint Mary's Regional Medical Center
      • Reno, Nevada, Forenede Stater, 89509
        • Radiation Oncology Associates
    • New Hampshire
      • Concord, New Hampshire, Forenede Stater, 03301
        • New Hampshire Oncology Hematology PA-Concord
      • Manchester, New Hampshire, Forenede Stater, 03103
        • Solinsky Center for Cancer Care
    • New Jersey
      • Basking Ridge, New Jersey, Forenede Stater, 07920
        • Memorial Sloan Kettering Basking Ridge
      • Middletown, New Jersey, Forenede Stater, 07748
        • Memorial Sloan Kettering Monmouth
      • Montvale, New Jersey, Forenede Stater, 07645
        • Memorial Sloan Kettering Bergen
    • New York
      • Buffalo, New York, Forenede Stater, 14263
        • Roswell Park Cancer Institute
      • Commack, New York, Forenede Stater, 11725
        • Memorial Sloan Kettering Commack
      • Harrison, New York, Forenede Stater, 10604
        • Memorial Sloan Kettering Westchester
      • New York, New York, Forenede Stater, 10065
        • Memorial Sloan Kettering Cancer Center
      • Uniondale, New York, Forenede Stater, 11553
        • Memorial Sloan Kettering Nassau
    • North Carolina
      • Albemarle, North Carolina, Forenede Stater, 28002
        • Atrium Health Stanly/LCI-Albemarle
      • Cary, North Carolina, Forenede Stater, 27518
        • Duke Cancer Center Cary
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Carolinas Medical Center/Levine Cancer Institute
      • Charlotte, North Carolina, Forenede Stater, 28210
        • Atrium Health Pineville/LCI-Pineville
      • Charlotte, North Carolina, Forenede Stater, 28262
        • Atrium Health University City/LCI-University
      • Charlotte, North Carolina, Forenede Stater, 28211
        • Levine Cancer Institute-SouthPark
      • Charlotte, North Carolina, Forenede Stater, 28277
        • Levine Cancer Institute-Ballantyne
      • Clinton, North Carolina, Forenede Stater, 28328
        • Southeastern Medical Oncology Center-Clinton
      • Concord, North Carolina, Forenede Stater, 28025
        • Atrium Health Cabarrus/LCI-Concord
      • Durham, North Carolina, Forenede Stater, 27710
        • Duke University Medical Center
      • Gastonia, North Carolina, Forenede Stater, 28054
        • Levine Cancer Institute-Gaston
      • Goldsboro, North Carolina, Forenede Stater, 27534
        • Southeastern Medical Oncology Center-Goldsboro
      • Jacksonville, North Carolina, Forenede Stater, 28546
        • Southeastern Medical Oncology Center-Jacksonville
      • Lincolnton, North Carolina, Forenede Stater, 28092
        • Atrium Health Lincoln/LCI-Lincolnton
      • Monroe, North Carolina, Forenede Stater, 28112
        • Atrium Health Union/LCI-Union
      • Pinehurst, North Carolina, Forenede Stater, 28374
        • FirstHealth of the Carolinas-Moore Regional Hospital
      • Raleigh, North Carolina, Forenede Stater, 27609
        • Duke Cancer Center Raleigh
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
        • Sanford Bismarck Medical Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Roger Maris Cancer Center
      • Fargo, North Dakota, Forenede Stater, 58122
        • Sanford Broadway Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Sanford South University Medical Center
      • Fargo, North Dakota, Forenede Stater, 58103
        • Southpointe-Sanford Medical Center Fargo
      • Fargo, North Dakota, Forenede Stater, 58104
        • Sanford Medical Center Fargo
    • Ohio
      • Beavercreek, Ohio, Forenede Stater, 45431
        • Indu and Raj Soin Medical Center
      • Belpre, Ohio, Forenede Stater, 45714
        • Strecker Cancer Center-Belpre
      • Boardman, Ohio, Forenede Stater, 44512
        • Saint Elizabeth Boardman Hospital
      • Centerville, Ohio, Forenede Stater, 45459
        • Miami Valley Hospital South
      • Centerville, Ohio, Forenede Stater, 45459
        • Dayton Physicians LLC-Miami Valley South
      • Chillicothe, Ohio, Forenede Stater, 45601
        • Adena Regional Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45219
        • University of Cincinnati Cancer Center-UC Medical Center
      • Cincinnati, Ohio, Forenede Stater, 45220
        • Good Samaritan Hospital - Cincinnati
      • Cincinnati, Ohio, Forenede Stater, 45242
        • Bethesda North Hospital
      • Cincinnati, Ohio, Forenede Stater, 45236
        • Oncology Hematology Care Inc-Kenwood
      • Cincinnati, Ohio, Forenede Stater, 45247
        • TriHealth Cancer Institute-Westside
      • Cincinnati, Ohio, Forenede Stater, 45255
        • TriHealth Cancer Institute-Anderson
      • Cleveland, Ohio, Forenede Stater, 44109
        • MetroHealth Medical Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Riverside Methodist Hospital
      • Columbus, Ohio, Forenede Stater, 43210
        • Ohio State University Comprehensive Cancer Center
      • Columbus, Ohio, Forenede Stater, 43219
        • The Mark H Zangmeister Center
      • Columbus, Ohio, Forenede Stater, 43214
        • Columbus Oncology and Hematology Associates Inc
      • Columbus, Ohio, Forenede Stater, 43228
        • Doctors Hospital
      • Columbus, Ohio, Forenede Stater, 43213
        • Mount Carmel East Hospital
      • Columbus, Ohio, Forenede Stater, 43215
        • Grant Medical Center
      • Columbus, Ohio, Forenede Stater, 43222
        • Mount Carmel Health Center West
      • Dayton, Ohio, Forenede Stater, 45409
        • Miami Valley Hospital
      • Dayton, Ohio, Forenede Stater, 45415
        • Miami Valley Hospital North
      • Dayton, Ohio, Forenede Stater, 45415
        • Dayton Physician LLC - Englewood
      • Dayton, Ohio, Forenede Stater, 45409
        • Premier Blood and Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Delaware Health Center-Grady Cancer Center
      • Delaware, Ohio, Forenede Stater, 43015
        • Grady Memorial Hospital
      • Dublin, Ohio, Forenede Stater, 43016
        • Dublin Methodist Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Blanchard Valley Hospital
      • Findlay, Ohio, Forenede Stater, 45840
        • Armes Family Cancer Center
      • Findlay, Ohio, Forenede Stater, 45840
        • Orion Cancer Care
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Atrium Medical Center-Middletown Regional Hospital
      • Franklin, Ohio, Forenede Stater, 45005
        • Dayton Physicians LLC-Atrium
      • Gahanna, Ohio, Forenede Stater, 43230
        • Central Ohio Breast and Endocrine Surgery
      • Greenville, Ohio, Forenede Stater, 45331
        • Wayne Hospital
      • Greenville, Ohio, Forenede Stater, 45331
        • Dayton Physicians LLC-Wayne
      • Greenville, Ohio, Forenede Stater, 45331
        • Miami Valley Cancer Care and Infusion
      • Grove City, Ohio, Forenede Stater, 43123
        • Mount Carmel Grove City Hospital
      • Kettering, Ohio, Forenede Stater, 45429
        • Kettering Medical Center
      • Kettering, Ohio, Forenede Stater, 45409
        • Greater Dayton Cancer Center
      • Lancaster, Ohio, Forenede Stater, 43130
        • Fairfield Medical Center
      • Lima, Ohio, Forenede Stater, 45801
        • Saint Rita's Medical Center
      • Mansfield, Ohio, Forenede Stater, 44903
        • OhioHealth Mansfield Hospital
      • Marietta, Ohio, Forenede Stater, 45750
        • Marietta Memorial Hospital
      • Marion, Ohio, Forenede Stater, 43302
        • OhioHealth Marion General Hospital
      • Marysville, Ohio, Forenede Stater, 43040
        • Memorial Hospital
      • Mount Vernon, Ohio, Forenede Stater, 43050
        • Knox Community Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Licking Memorial Hospital
      • Newark, Ohio, Forenede Stater, 43055
        • Newark Radiation Oncology
      • Perrysburg, Ohio, Forenede Stater, 43551
        • Mercy Health - Perrysburg Hospital
      • Portsmouth, Ohio, Forenede Stater, 45662
        • Southern Ohio Medical Center
      • Springfield, Ohio, Forenede Stater, 45504
        • Springfield Regional Cancer Center
      • Springfield, Ohio, Forenede Stater, 45504
        • Springfield Regional Medical Center
      • Toledo, Ohio, Forenede Stater, 43623
        • Mercy Health - Saint Anne Hospital
      • Toledo, Ohio, Forenede Stater, 43608
        • Mercy Health - Saint Vincent Hospital
      • Troy, Ohio, Forenede Stater, 45373
        • Upper Valley Medical Center
      • Troy, Ohio, Forenede Stater, 45373
        • Dayton Physicians LLC - Troy
      • Warren, Ohio, Forenede Stater, 44484
        • Saint Joseph Warren Hospital
      • West Chester, Ohio, Forenede Stater, 45069
        • University of Cincinnati Cancer Center-West Chester
      • Westerville, Ohio, Forenede Stater, 43081
        • Saint Ann's Hospital
      • Youngstown, Ohio, Forenede Stater, 44501
        • Saint Elizabeth Youngstown Hospital
      • Zanesville, Ohio, Forenede Stater, 43701
        • Genesis Healthcare System Cancer Care Center
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • University of Oklahoma Health Sciences Center
      • Oklahoma City, Oklahoma, Forenede Stater, 73120
        • Mercy Hospital Oklahoma City
    • Oregon
      • Baker City, Oregon, Forenede Stater, 97814
        • Saint Alphonsus Cancer Care Center-Baker City
      • Bend, Oregon, Forenede Stater, 97701
        • Saint Charles Health System
      • Clackamas, Oregon, Forenede Stater, 97015
        • Clackamas Radiation Oncology Center
      • Clackamas, Oregon, Forenede Stater, 97015
        • Providence Cancer Institute Clackamas Clinic
      • Coos Bay, Oregon, Forenede Stater, 97420
        • Bay Area Hospital
      • Newberg, Oregon, Forenede Stater, 97132
        • Providence Newberg Medical Center
      • Ontario, Oregon, Forenede Stater, 97914
        • Saint Alphonsus Cancer Care Center-Ontario
      • Oregon City, Oregon, Forenede Stater, 97045
        • Providence Willamette Falls Medical Center
      • Portland, Oregon, Forenede Stater, 97239
        • Oregon Health and Science University
      • Portland, Oregon, Forenede Stater, 97213
        • Providence Portland Medical Center
      • Portland, Oregon, Forenede Stater, 97225
        • Providence Saint Vincent Medical Center
      • Redmond, Oregon, Forenede Stater, 97756
        • Saint Charles Health System-Redmond
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Lehigh Valley Hospital-Cedar Crest
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Lehigh Valley Hospital - Muhlenberg
      • Chadds Ford, Pennsylvania, Forenede Stater, 19317
        • Christiana Care Health System-Concord Health Center
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Geisinger Medical Center
      • East Stroudsburg, Pennsylvania, Forenede Stater, 18301
        • Pocono Medical Center
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Geisinger Medical Center-Cancer Center Hazleton
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Lehigh Valley Hospital-Hazleton
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Geisinger Medical Oncology-Lewisburg
      • Philadelphia, Pennsylvania, Forenede Stater, 19107
        • Pennsylvania Hospital
      • Pottsville, Pennsylvania, Forenede Stater, 17901
        • Geisinger Cancer Services-Pottsville
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Community Medical Center
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Geisinger Wyoming Valley/Henry Cancer Center
    • South Carolina
      • Greenville, South Carolina, Forenede Stater, 29607
        • Saint Francis Cancer Center
      • Greenville, South Carolina, Forenede Stater, 29601
        • Saint Francis Hospital
      • Rock Hill, South Carolina, Forenede Stater, 29732
        • Levine Cancer Institute-Rock Hill
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
        • Sanford USD Medical Center - Sioux Falls
      • Sioux Falls, South Dakota, Forenede Stater, 57104
        • Sanford Cancer Center Oncology Clinic
    • Tennessee
      • Knoxville, Tennessee, Forenede Stater, 37916
        • Covenant Health Cancer Centers
      • Knoxville, Tennessee, Forenede Stater, 37932
        • Covenant Health Cancer Centers - West
      • Lenoir City, Tennessee, Forenede Stater, 37772
        • Covenant Health Oncology Group - Lenoir City
      • Nashville, Tennessee, Forenede Stater, 37232
        • Vanderbilt University/Ingram Cancer Center
      • Oak Ridge, Tennessee, Forenede Stater, 37830
        • Covenant Health Oncology Group - Oak Ridge
    • Texas
      • Bryan, Texas, Forenede Stater, 77802
        • Saint Joseph Regional Cancer Center
      • Conroe, Texas, Forenede Stater, 77384
        • MD Anderson in The Woodlands
      • Dallas, Texas, Forenede Stater, 75235
        • Parkland Memorial Hospital
      • Dallas, Texas, Forenede Stater, 75390
        • UT Southwestern/Simmons Cancer Center-Dallas
      • Dallas, Texas, Forenede Stater, 75237
        • UT Southwestern Simmons Cancer Center - RedBird
      • Fort Worth, Texas, Forenede Stater, 76104
        • UT Southwestern/Simmons Cancer Center-Fort Worth
      • Houston, Texas, Forenede Stater, 77030
        • M D Anderson Cancer Center
      • Houston, Texas, Forenede Stater, 77079
        • MD Anderson West Houston
      • League City, Texas, Forenede Stater, 77573
        • MD Anderson League City
      • Richardson, Texas, Forenede Stater, 75080
        • UT Southwestern Clinical Center at Richardson/Plano
      • Sugar Land, Texas, Forenede Stater, 77478
        • MD Anderson in Sugar Land
    • Virginia
      • Chesapeake, Virginia, Forenede Stater, 23320
        • Cancer Specialists of Tidewater Limited
      • Fredericksburg, Virginia, Forenede Stater, 22408
        • Hematology Oncology Associates of Fredericksburg Inc
      • Gloucester, Virginia, Forenede Stater, 23061
        • Peninsula Cancer Institute-Gloucester
      • Newport News, Virginia, Forenede Stater, 23601
        • Peninsula Cancer Institute-Newport News
      • Richmond, Virginia, Forenede Stater, 23229
        • Virginia Cancer Institute
      • Richmond, Virginia, Forenede Stater, 23298
        • VCU Massey Comprehensive Cancer Center
      • Suffolk, Virginia, Forenede Stater, 23435
        • Cancer Specialists of Tidewater-Suffolk
      • Virginia Beach, Virginia, Forenede Stater, 23454
        • Peninsula Cancer Institute-Cancer Specialists of Tidewater
      • Williamsburg, Virginia, Forenede Stater, 23185
        • Peninsula Cancer Institute-Williamsburg
    • Washington
      • Aberdeen, Washington, Forenede Stater, 98520
        • Providence Regional Cancer System-Aberdeen
      • Bellevue, Washington, Forenede Stater, 98004
        • Overlake Medical Center
      • Bellingham, Washington, Forenede Stater, 98225
        • PeaceHealth Saint Joseph Medical Center
      • Burien, Washington, Forenede Stater, 98166
        • Highline Medical Center-Main Campus
      • Centralia, Washington, Forenede Stater, 98531
        • Providence Regional Cancer System-Centralia
      • Edmonds, Washington, Forenede Stater, 98026
        • Swedish Cancer Institute-Edmonds
      • Enumclaw, Washington, Forenede Stater, 98022
        • Saint Elizabeth Hospital
      • Everett, Washington, Forenede Stater, 98201
        • Providence Regional Cancer Partnership
      • Federal Way, Washington, Forenede Stater, 98003
        • Saint Francis Hospital
      • Issaquah, Washington, Forenede Stater, 98029
        • Swedish Cancer Institute-Issaquah
      • Kennewick, Washington, Forenede Stater, 99336
        • Kadlec Clinic Hematology and Oncology
      • Lacey, Washington, Forenede Stater, 98503
        • Providence Regional Cancer System-Lacey
      • Lakewood, Washington, Forenede Stater, 98499
        • Saint Clare Hospital
      • Longview, Washington, Forenede Stater, 98632
        • PeaceHealth Saint John Medical Center
      • Poulsbo, Washington, Forenede Stater, 98370
        • Harrison HealthPartners Hematology and Oncology-Poulsbo
      • Renton, Washington, Forenede Stater, 98055
        • Valley Medical Center
      • Seattle, Washington, Forenede Stater, 98107
        • Swedish Medical Center-Ballard Campus
      • Seattle, Washington, Forenede Stater, 98122
        • Swedish Medical Center-First Hill
      • Seattle, Washington, Forenede Stater, 98104
        • Pacific Gynecology Specialists
      • Seattle, Washington, Forenede Stater, 98122-5711
        • Swedish Medical Center-Cherry Hill
      • Sedro-Woolley, Washington, Forenede Stater, 98284
        • PeaceHealth United General Medical Center
      • Shelton, Washington, Forenede Stater, 98584
        • Providence Regional Cancer System-Shelton
      • Silverdale, Washington, Forenede Stater, 98383
        • Saint Joseph Medical Center Hematology and Oncology - Silverdale
      • Tacoma, Washington, Forenede Stater, 98405
        • Northwest Medical Specialties PLLC
      • Tacoma, Washington, Forenede Stater, 98405
        • Franciscan Research Center-Northwest Medical Plaza
      • Vancouver, Washington, Forenede Stater, 98664
        • PeaceHealth Southwest Medical Center
      • Walla Walla, Washington, Forenede Stater, 99362
        • Providence Saint Mary Regional Cancer Center
      • Yakima, Washington, Forenede Stater, 98902
        • North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
      • Yelm, Washington, Forenede Stater, 98597
        • Providence Regional Cancer System-Yelm
    • West Virginia
      • Bridgeport, West Virginia, Forenede Stater, 26330
        • United Hospital Center
      • Martinsburg, West Virginia, Forenede Stater, 25401
        • WVUH-Berkely Medical Center
      • Morgantown, West Virginia, Forenede Stater, 26506
        • West Virginia University Healthcare
      • Parkersburg, West Virginia, Forenede Stater, 26101
        • Camden Clark Medical Center
    • Wisconsin
      • Appleton, Wisconsin, Forenede Stater, 54911
        • ThedaCare Regional Cancer Center
      • Eau Claire, Wisconsin, Forenede Stater, 54701
        • Marshfield Medical Center-EC Cancer Center
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Gundersen Lutheran Medical Center
      • Marshfield, Wisconsin, Forenede Stater, 54449
        • Marshfield Medical Center-Marshfield
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Medical College of Wisconsin
      • Minocqua, Wisconsin, Forenede Stater, 54548
        • Marshfield Medical Center - Minocqua
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • ProHealth D N Greenwald Center
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Cancer Center of Western Wisconsin
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • ProHealth Oconomowoc Memorial Hospital
      • Rice Lake, Wisconsin, Forenede Stater, 54868
        • Marshfield Medical Center-Rice Lake
      • Stevens Point, Wisconsin, Forenede Stater, 54482
        • Marshfield Medical Center-River Region at Stevens Point
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • UW Cancer Center at ProHealth Care
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • ProHealth Waukesha Memorial Hospital
      • Waupaca, Wisconsin, Forenede Stater, 54981
        • ThedaCare Cancer Care - Waupaca
      • Weston, Wisconsin, Forenede Stater, 54476
        • Marshfield Medical Center - Weston
    • Wyoming
      • Cody, Wyoming, Forenede Stater, 82414
        • Billings Clinic-Cody
      • Sheridan, Wyoming, Forenede Stater, 82801
        • Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

  • Patienten skal have inoperabel, tilbagevendende eller metastatisk sygdom, der ikke er modtagelig for helbredende terapi
  • Patienten skal have histologisk eller cytologisk bekræftelse af anal pladecellecarcinom (inklusive basaloid- og kloakogene læsioner) fra den primære tumor eller en nyligt diagnosticeret tilbagevendende/metastatisk læsion
  • Patienten skal være >= 18 år gammel
  • Patienten skal have Eastern Cooperative Oncology Group (ECOG) præstationsstatus =< 0-1
  • Patienter skal have målbar sygdom i henhold til Respons Evaluation Criteria in Solid Tumors (RECIST) kriterier version 1.1 og baseret på radiologisk vurdering udført < 4 uger før randomisering
  • Patient, der modtager palliativ (begrænset felt) strålebehandling er tilladt, så længe læsionen, der behandles til palliation, ikke er en mållæsion og er > 7 dage fra afslutningen fra palliativ stråling
  • Patienter med hjernemetastaser er kvalificerede, hvis patienten er asymptomatisk, og hvis behandlingen er afsluttet > 3 måneder før randomisering. Patienter med behandlede hjernemetastaser er berettigede, hvis opfølgende hjernebilleddannelse efter centralnervesystem (CNS)-styret terapi ikke viser tegn på progression inden for 4 uger før randomisering
  • Absolut neutrofiltal >= 1.500/mcL (opnået < 14 dage før randomisering)
  • Blodplader >= 100.000/mcL (opnået < 14 dage før randomisering)
  • Hæmoglobin (Hb) >= 9 g/dL for mænd og >= 9 g/dL for kvinder (opnået < 14 dage før randomisering)
  • Total bilirubin =< 1,5 x institutionel øvre normalgrænse (ULN) (opnået < 14 dage før randomisering)
  • Aspartattransaminase (AST)(serumglutamin-oxaloeddiketransaminase [SGOT]) /alanintransferase (ALT)(serumglutamatpyruvattransaminase [SGPT]) =< 5 x institutionel ULN (opnået < 14 dage før randomisering)
  • Kreatinin =< 1,5 x institutionel ULN ELLER kreatininclearance (CrCl) >= 50 ml/min (hvis du bruger Cockcroft-Gault-formlen) (opnået < 14 dage før randomisering)

  • Human immundefektvirus (HIV)-inficerede patienter i effektiv antiretroviral terapi (ART) med CD4-tal >= 200 eller har et CD4-tal < 200, men en upåviselig virusmængde er kvalificerede

    • Alle HIV+-patienter bør være under behandling af en infektionssygdomsspecialist. Hvis et forhold til en infektionsspecialist ikke er etableret, bør en infektionsspecialist konsulteres. Registreringer af alle virale tællinger og perifere T-celle tællinger bør dokumenteres for at følge disse værdier i løbet af behandlingen
    • Alle patienter skal være villige til at gennemgå test for HIV-test, hvis de ikke er testet inden for de seneste 12 måneder
  • For patienter med tegn på kronisk hepatitis B-virus (HBV)-infektion skal HBV-virusmængden være upåviselig eller under suppressiv behandling (hvis indiceret)
  • Patienter med en historie med hepatitis C-virus (HCV)-infektion skal være blevet behandlet og helbredt. For patienter med HCV-infektion, som i øjeblikket er i behandling, er de berettigede, hvis de har en upåviselig HCV-virusbelastning
  • Patienter med kendt anamnese eller aktuelle symptomer på hjertesygdom bør have en klinisk risikovurdering af hjertefunktionen ved hjælp af New York Heart Association Functional Classification. For at være berettiget til dette forsøg skal patienter være klasse 2B eller bedre. Patienter med en historie med kongestiv hjerteinsufficiens (CHF) eller som er i risikogruppen på grund af underliggende kardiovaskulær sygdom eller eksponering for kardiotoksiske lægemidler skal være villige til at gennemgå en evaluering af hjertefunktionen, herunder elektrokardiogram (EKG) og ekkokardiogram (ECHO) som klinisk indiceret
  • Patienten skal have evnen til at forstå og være villig til at underskrive et skriftligt informeret samtykkedokument. Patienter med nedsat beslutningsevne (IDMC), som har en juridisk autoriseret repræsentant (LAR) eller omsorgsperson og/eller familiemedlem til rådighed, vil også blive betragtet som kvalificerede
  • Patienter skal acceptere ikke at modtage levende vacciner under denne undersøgelse

Ekskluderingskriterier:

  • Kvinder må ikke være gravide eller ammende på grund af den potentielle skade på et ufødt foster og mulig risiko for bivirkninger hos ammende spædbørn med de behandlingsregimer, der anvendes. Alle kvinder i den fødedygtige alder skal have en blodprøve eller urinundersøgelse med en minimumsfølsomhed på 25 IE/L eller tilsvarende enheder af Bacille Calmette-Guerin (BCG) inden for 14 dage før randomisering for at udelukke graviditet. En kvinde i den fødedygtige alder defineres som enhver kvinde, uanset seksuel orientering, eller om de har gennemgået tubal ligering, som opfylder følgende kriterier: 1) har opnået menarche på et tidspunkt, 2) ikke har gennemgået en hysterektomi eller bilateral oophorektomi; eller 2) ikke har været naturligt postmenopausal (amenoré efter cancerbehandling udelukker ikke den fødedygtige alder) i mindst 24 på hinanden følgende måneder (dvs. har haft menstruation på noget tidspunkt i de foregående 24 på hinanden følgende måneder).
  • Kvinder i den fødedygtige alder og seksuelt aktive mænd må ikke forvente at blive gravide eller få børn ved at bruge accepterede og effektive præventionsmetoder eller at afholde sig fra samleje i mindst en uge før påbegyndelse af behandlingen og fortsætte i 5 måneder efter den sidste dosis protokolbehandling til kvinder i den fertile alder og 7 måneder efter den sidste dosis protokolbehandling til mænd, der er seksuelt aktive med kvinder i den fertile alder (WOCBP)
  • Patienten må ikke tidligere have haft systemisk kemoterapi eller andre undersøgelseslægemidler til behandling af inoperabel tilbagevendende eller metastatisk analcancer (tidligere brug af strålebehandling eller kemoradioterapi i denne indstilling er ikke et udelukkelseskriterium, hvis: 1) ikke-bestrålede måltumorlæsioner er til stede ved randomisering med henblik på vurdering af tumorrespons eller 2) i fravær af ikke-bestrålede måltumorlæsioner, er progression af de bestrålede tumorlæsioner i henhold til RECIST-kriterierne version 1.1 dokumenteret)
  • Patienten må ikke have aktuel eller nylig (inden for 30 dage før randomisering) behandling med et andet forsøgslægemiddel eller deltagelse i en anden undersøgelsesundersøgelse
  • Patienten må ikke have haft tidligere immunterapi
  • Patienten må ikke have en historie med kendt overfølsomhedsreaktion over for platin- eller taxan-baseret kemoterapi eller monoklonalt antistof
  • Patienten må ikke have aktiv autoimmun sygdom eller en historie med autoimmun sygdom, der kan opstå igen, hvilket kan påvirke vitale organers funktion eller kræve immunsuppressiv behandling inklusive kroniske forlængede systemiske kortikosteroider (defineret som kortikosteroidbrug af varighed en måned eller mere). Disse omfatter, men er ikke begrænset til, patienter med en historie med immunrelateret neurologisk sygdom, multipel sklerose, autoimmun (demyeliniserende) neuropati, Guillain-Barre syndrom, myasthenia gravis; systemisk autoimmun sygdom såsom systemisk lupus erythematosus (SLE), bindevævssygdomme, sklerodermi, inflammatorisk tarmsygdom (IBD), Crohns, colitis ulcerosa og patienter med en historie med toksisk epidermal nekrolyse (TEN), Stevens-Johnsons syndrom eller anti -phospholipid syndrom. Patienter med nogen af ​​disse er ikke berettigede på grund af risikoen for gentagelse eller forværring af autoimmun sygdom
  • Patienten må ikke have en tilstand, der kræver systemisk behandling med enten kortikosteroider (> 10 mg dagligt prednisonækvivalenter) eller anden immunsuppressiv medicin inden for 14 dage efter randomisering. Inhalerede eller topiske steroider og binyrerestatningsdoser < 10 mg daglige prednisonækvivalenter er tilladt i fravær af aktiv autoimmun sygdom. Patienter har tilladelse til at bruge topikale, okulære, intraartikulære, intranasale og inhalationskortikosteroider (med minimal systemisk absorption). Fysiologiske erstatningsdoser af systemiske kortikosteroider er tilladt, selvom < 10 mg/dag prednisonækvivalenter. En kort kur med kortikosteroider til profylakse (f.eks. kontrastfarveallergi) eller til behandling af ikke-autoimmune tilstande (f.eks. forsinket overfølsomhedsreaktion forårsaget af kontaktallergen) er tilladt
  • Patienten må ikke have fået foretaget større operation =< 28 dage før randomisering
  • Patienten må ikke have en historie med interstitiel lungesygdom (f.eks. lungebetændelse eller lungefibrose) eller tegn på interstitiel lungesygdom på baseline thorax computertomografi (CT) scanning
  • Patienten må ikke have en alvorlig aktiv infektion, der kræver IV-antibiotika på tidspunktet for randomisering
  • Patienten må ikke have anden primær malignitet inden for de sidste 3 år, bortset fra tilstrækkeligt behandlet carcinom in situ i livmoderhalsen eller pladecellekarcinom i huden, eller tilstrækkeligt kontrolleret begrænset basalcellehudkræft eller enhver anden cancer, som patienten har været sygdom af. -gratis i mindst 3 år
  • Patienten må ikke have kendt perifer neuropati > grad 1 på randomiseringstidspunktet (fravær af dybe senereflekser, da den eneste neurologiske abnormitet ikke gør patienten uegnet)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Arm A (carboplatin, paclitaxel)
Patienterne får paclitaxel IV på dag 1, 8 og 15 i hver cyklus og carboplatin IV på dag 1 i hver cyklus. Behandlingen gentages hver 28. dag i op til 6 cyklusser i fravær af sygdomsprogression eller uacceptabel toksicitet.
Medicin: Carboplatin
Givet IV
Andre navne:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carboplatin
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatin
  • Paraplatin
  • Paraplatin AQ
  • Platinwas
  • Ribocarbo
  • JM8
Medicin: Paclitaxel
Givet IV
Andre navne:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat
Eksperimentel: Arm B (carboplatin, paclitaxel, nivolumab)
Patienterne får nivolumab IV over 30 minutter på dag 1 og 15 i cyklus 1 og derefter kun på dag 1 i efterfølgende cyklusser, paclitaxel IV på dag 1, 8 og 15 i hver cyklus og carboplatin på dag 1 i hver cyklus. Behandlingen gentages hver 28. dag i op til 6 cyklusser for carboplatin og paclitaxel og op til 2 år for nivolumab i fravær af sygdomsprogression eller uacceptabel toksicitet.
Medicin: Carboplatin
Givet IV
Andre navne:
  • Blastocarb
  • Carboplat
  • Carboplatin Hexal
  • Carboplatino
  • Carboplatin
  • Carbosin
  • Carbosol
  • Carbotec
  • CBDCA
  • Displata
  • Ercar
  • JM-8
  • Nealorin
  • Novoplatin
  • Paraplatin
  • Paraplatin AQ
  • Platinwas
  • Ribocarbo
  • JM8
Biologisk: Nivolumab
Givet IV
Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538
Medicin: Paclitaxel
Givet IV
Andre navne:
  • Taxol
  • Anzatax
  • Asotax
  • Bristaxol
  • Praxel
  • Taxol Konzentrat

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Progression-fri overlevelse (PFS)
Tidsramme: Op til 2 år
Defineret som den første af progressiv sygdom eller død på grund af nogen årsag. Analyseret ved hjælp af en stratificeret tosidet samlet 0,05 niveau log-rank test. Vil anvende standard Eastern Cooperative Oncology Group -American College of Radiology Imaging Network Interim Monitoring til effektivitetsevaluering.
Op til 2 år

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Objektiv svarprocent (ORR)
Tidsramme: Op til 2 år
ORR er forholdet mellem antallet af patienter med et fuldstændigt eller delvist respons, som defineret af Respons Evaluation Criteria i Solid Tumors version 1.1, og det samlede antal behandlede patienter.
Op til 2 år
Samlet overlevelse
Tidsramme: Tid mellem behandlingsrandomisering og død uanset årsag, vurderet op til 2 år
Evalueret ved en stratificeret log-rank test og ved hjælp af en tosidet 0,05 niveau Cochran Mantel-Haenzel.
Tid mellem behandlingsrandomisering og død uanset årsag, vurderet op til 2 år
Forekomst af uønskede hændelser
Tidsramme: Op til 2 år
Analyser af toksicitet vil være via frekvenstabeller og procenter efter værste grad af toksicitet, og sammenligninger vil blive udført via chi-square eller Fishers eksakte test, alt efter hvad der er relevant.
Op til 2 år
Association of PFS med human papillomavirus (HPV) cirkulerende cellefri deoxyribonukleinsyre (DNA) viral belastning
Tidsramme: Op til 2 år
Vil bruge en kvantitativ HPV-test baseret på SafeseQ Next Generation Sequencing Technology til at detektere tumorafledte HPV16- og HPV18-DNA-sekvenser, der er til stede i plasmaet.
Op til 2 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

National Cancer Institute (NCI)

Efterforskere

  • Ledende efterforsker: Cathy Eng, ECOG-ACRIN Cancer Research Group

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

17. november 2020

Primær færdiggørelse (Anslået)

31. marts 2027

Studieafslutning (Anslået)

31. marts 2027

Datoer for studieregistrering

Først indsendt

23. juni 2020

Først indsendt, der opfyldte QC-kriterier

23. juni 2020

Først opslået (Faktiske)

24. juni 2020

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

29. maj 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

28. maj 2026

Sidst verificeret

1. marts 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • NCI-2020-04334 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • U10CA180820 (U.S. NIH-bevilling/kontrakt)
  • EA2176 (Anden identifikator: CTEP)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

JA

IPD-planbeskrivelse

NCI er forpligtet til at dele data i overensstemmelse med NIHs politik. For flere detaljer om, hvordan kliniske forsøgsdata deles, skal du gå til linket til NIH-siden for datadelingspolitik

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Anal basaloid karcinom

Kliniske forsøg med Carboplatin

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Saint Lucia

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer

Abonner