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Test af virkningerne af MK-3475 (Pembrolizumab) med eller uden den sædvanlige kemoterapibehandling til patienter i alderen 70 år og ældre med avanceret ikke-småcellet lungekræft

4. juni 2025 opdateret af: Alliance for Clinical Trials in Oncology

Ældre ikke-småcellet lungekræftpatienter (>/= 70 år) behandlet med First-Line MK-3475 (Pembrolizumab)+/- Kemoterapi (Onkologs/Patientens valg)

Dette forsøg studerer bivirkningerne af pembrolizumab med eller uden kemoterapi til behandling af patienter med fase IV ikke-småcellet lungekræft, der er vendt tilbage (tilbagevendende) og har spredt sig til andre steder i kroppen (avanceret). Immunterapi med monoklonale antistoffer, såsom pembrolizumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig. Lægemidler, der bruges i kemoterapi, såsom pemetrexed og carboplatin, virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. At give pembrolizumab med eller uden kemoterapi kan skrumpe tumoren hos ældre patienter med ikke-småcellet lungekræft.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsens primære og sekundære mål:

PRIMÆR MÅL:

I. At estimere bivirkningsprofilen for MK-3475 (pembrolizumab) hos ikke-småcellet lungecancerpatienter, som er 70 år eller ældre, og som er behandlet med MK-3475 (pembrolizumab) +/- kemoterapi i en første -linjeindstilling.

SEKUNDÆRE MÅL:

I. At vurdere den samlede overlevelse. II. At beskrive patientens livskvalitet under behandlingen ved hjælp af Linear Analogue Self-Assessment (LASA) spørgeskemaet.

III. At undersøge, om Comprehensive Geriatric Assessment (CGA)-afledt risikoscore er i stand til at forudsige antallet af alvorlige bivirkninger hos ældre cancerpatienter, der modtager MK-3475 (pembrolizumab) eller MK-3475 (pembrolizumab) + kemoterapi.

OVERSIGT: Patienter tildeles 1 af 2 grupper.

GRUPPE A: Patienter får pembrolizumab intravenøst (IV) over 30 minutter på dag 1. Cykler gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

GRUPPE B: Patienterne får pembrolizumab IV over 30 minutter, pemetrexed IV over 10 minutter og carboplatin IV i henhold til institutionelle retningslinjer på dag 1. Cykler gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.

Efter afsluttet undersøgelsesbehandling følges patienter årligt i op til 5 år efter registrering.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

101

Fase

Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alaska
  - Anchorage, Alaska, Forenede Stater, 98508
    - Anchorage Associates in Radiation Medicine
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Breast Care and Surgery LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Oncology and Hematology LLC
  - Anchorage, Alaska, Forenede Stater, 99508
    - Alaska Women's Cancer Care
  - Anchorage, Alaska, Forenede Stater, 99508
    - Anchorage Oncology Centre
  - Anchorage, Alaska, Forenede Stater, 99508
    - Katmai Oncology Group
  - Anchorage, Alaska, Forenede Stater, 99508
    - Providence Alaska Medical Center
  - Anchorage, Alaska, Forenede Stater, 99504
    - Anchorage Radiation Therapy Center
  - Fairbanks, Alaska, Forenede Stater, 99701
    - Fairbanks Memorial Hospital
- Arizona
  - Kingman, Arizona, Forenede Stater, 86401
    - Kingman Regional Medical Center
- California
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Arroyo Grande, California, Forenede Stater, 93420
    - Mission Hope Medical Oncology - Arroyo Grande
  - La Jolla, California, Forenede Stater, 92093
    - UC San Diego Moores Cancer Center
  - Saint Helena, California, Forenede Stater, 94574
    - Saint Helena Hospital
  - San Luis Obispo, California, Forenede Stater, 93401
    - Pacific Central Coast Health Center-San Luis Obispo
  - Santa Maria, California, Forenede Stater, 93444
    - Mission Hope Medical Oncology - Santa Maria
- Colorado
  - Aurora, Colorado, Forenede Stater, 80012
    - Rocky Mountain Cancer Centers-Aurora
  - Aurora, Colorado, Forenede Stater, 80012
    - The Medical Center of Aurora
  - Boulder, Colorado, Forenede Stater, 80303
    - Boulder Community Foothills Hospital
  - Boulder, Colorado, Forenede Stater, 80304
    - Rocky Mountain Cancer Centers-Boulder
  - Centennial, Colorado, Forenede Stater, 80112
    - Rocky Mountain Cancer Centers - Centennial
  - Colorado Springs, Colorado, Forenede Stater, 80907
    - Penrose-Saint Francis Healthcare
  - Denver, Colorado, Forenede Stater, 80210
    - Porter Adventist Hospital
  - Denver, Colorado, Forenede Stater, 80218
    - Presbyterian - Saint Lukes Medical Center - Health One
  - Denver, Colorado, Forenede Stater, 80218
    - SCL Health Saint Joseph Hospital
  - Denver, Colorado, Forenede Stater, 80220
    - Rose Medical Center
  - Denver, Colorado, Forenede Stater, 80218
    - Rocky Mountain Cancer Centers-Midtown
  - Denver, Colorado, Forenede Stater, 80220
    - Rocky Mountain Cancer Centers-Rose
  - Denver, Colorado, Forenede Stater, 80218
    - Colorado Blood Cancer Institute
  - Denver, Colorado, Forenede Stater, 80209
    - The Women's Imaging Center
  - Denver, Colorado, Forenede Stater, 80206
    - National Jewish Health-Main Campus
  - Denver, Colorado, Forenede Stater, 80220
    - Western Surgical Care
  - Englewood, Colorado, Forenede Stater, 80113
    - Mountain Blue Cancer Care Center - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - Swedish Medical Center
  - Englewood, Colorado, Forenede Stater, 80113
    - Rocky Mountain Cancer Centers - Swedish
  - Englewood, Colorado, Forenede Stater, 80113
    - The Melanoma and Skin Cancer Institute
  - Golden, Colorado, Forenede Stater, 80401
    - National Jewish Health-Western Hematology Oncology
  - Grand Junction, Colorado, Forenede Stater, 81501
    - Saint Mary's Hospital and Regional Medical Center
  - Greeley, Colorado, Forenede Stater, 80631
    - North Colorado Medical Center
  - Lakewood, Colorado, Forenede Stater, 80228
    - Saint Anthony Hospital
  - Lakewood, Colorado, Forenede Stater, 80228
    - Rocky Mountain Cancer Centers-Lakewood
  - Littleton, Colorado, Forenede Stater, 80120
    - Rocky Mountain Cancer Centers-Littleton
  - Littleton, Colorado, Forenede Stater, 80122
    - Littleton Adventist Hospital
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Sky Ridge Medical Center
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Rocky Mountain Cancer Centers-Sky Ridge
  - Longmont, Colorado, Forenede Stater, 80501
    - Longmont United Hospital
  - Loveland, Colorado, Forenede Stater, 80539
    - McKee Medical Center
  - Parker, Colorado, Forenede Stater, 80138
    - Parker Adventist Hospital
  - Pueblo, Colorado, Forenede Stater, 81004
    - Saint Mary Corwin Medical Center
  - Thornton, Colorado, Forenede Stater, 80260
    - Rocky Mountain Cancer Centers-Thornton
  - Thornton, Colorado, Forenede Stater, 80260
    - National Jewish Health-Northern Hematology Oncology
  - Wheat Ridge, Colorado, Forenede Stater, 80033
    - SCL Health Lutheran Medical Center
- Delaware
  - Frankford, Delaware, Forenede Stater, 19945
    - Beebe South Coastal Health Campus
  - Lewes, Delaware, Forenede Stater, 19958
    - Beebe Medical Center
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Delaware Clinical and Laboratory Physicians PA
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Newark, Delaware, Forenede Stater, 19718
    - Christiana Care Health System-Christiana Hospital
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
  - Wilmington, Delaware, Forenede Stater, 19801
    - Christiana Care Health System-Wilmington Hospital
- Florida
  - Clearwater, Florida, Forenede Stater, 33756
    - Morton Plant Hospital
  - Plant City, Florida, Forenede Stater, 33563
    - South Florida Baptist Hospital
  - Saint Petersburg, Florida, Forenede Stater, 33705
    - Saint Anthony's Hospital Cancer Care Center
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center
  - Tampa, Florida, Forenede Stater, 33607
    - Moffitt Cancer Center-International Plaza
  - Tampa, Florida, Forenede Stater, 33607
    - Saint Joseph's Hospital/Children's Hospital-Tampa
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center - McKinley Campus
  - Wesley Chapel, Florida, Forenede Stater, 33544
    - Moffitt Cancer Center at Wesley Chapel
  - Winter Haven, Florida, Forenede Stater, 33881
    - Winter Haven Hospital
- Georgia
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Emmett, Idaho, Forenede Stater, 83617
    - Walter Knox Memorial Hospital
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Idaho Urologic Institute-Meridian
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Cancer Institute - Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Cancer Clinic
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Centralia, Illinois, Forenede Stater, 62801
    - Centralia Oncology Clinic
  - Centralia, Illinois, Forenede Stater, 62801
    - Saint Mary's Hospital
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60612
    - Jesse Brown Veterans Affairs Medical Center
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Harvey, Illinois, Forenede Stater, 60426
    - Ingalls Memorial Hospital
  - Joliet, Illinois, Forenede Stater, 60435
    - Duly Health and Care Joliet
  - Mount Vernon, Illinois, Forenede Stater, 62864
    - Good Samaritan Regional Health Center
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - River Forest, Illinois, Forenede Stater, 60305
    - West Suburban Medical Center
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Urbana, Illinois, Forenede Stater, 61801
    - The Carle Foundation Hospital
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
- Iowa
  - Ames, Iowa, Forenede Stater, 50010
    - Mary Greeley Medical Center
  - Ames, Iowa, Forenede Stater, 50010
    - McFarland Clinic - Ames
  - Boone, Iowa, Forenede Stater, 50036
    - McFarland Clinic - Boone
  - Carroll, Iowa, Forenede Stater, 51401
    - Saint Anthony Regional Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52402
    - Physicians' Clinic of Iowa PC
  - Clive, Iowa, Forenede Stater, 50325
    - Mercy Cancer Center-West Lakes
  - Clive, Iowa, Forenede Stater, 50325
    - Medical Oncology and Hematology Associates-West Des Moines
  - Council Bluffs, Iowa, Forenede Stater, 51502
    - Jennie Edmundson Memorial Hospital
  - Council Bluffs, Iowa, Forenede Stater, 51503
    - Heartland Oncology and Hematology LLP
  - Creston, Iowa, Forenede Stater, 50801
    - Greater Regional Medical Center
  - Des Moines, Iowa, Forenede Stater, 50309
    - Iowa Methodist Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
  - Des Moines, Iowa, Forenede Stater, 50314
    - Broadlawns Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mission Cancer and Blood - Laurel
  - Des Moines, Iowa, Forenede Stater, 50316
    - Iowa Lutheran Hospital
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - Trinity Regional Medical Center
  - Fort Dodge, Iowa, Forenede Stater, 50501
    - McFarland Clinic - Trinity Cancer Center
  - Jefferson, Iowa, Forenede Stater, 50129
    - McFarland Clinic - Jefferson
  - Marshalltown, Iowa, Forenede Stater, 50158
    - McFarland Clinic - Marshalltown
  - West Des Moines, Iowa, Forenede Stater, 50266-7700
    - Methodist West Hospital
  - West Des Moines, Iowa, Forenede Stater, 50266
    - Mercy Medical Center-West Lakes
- Louisiana
  - Monroe, Louisiana, Forenede Stater, 71202
    - Ochsner LSU Health Monroe Medical Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
  - New Orleans, Louisiana, Forenede Stater, 70112
    - Louisiana State University Health Science Center
  - Shreveport, Louisiana, Forenede Stater, 71103
    - LSU Health Sciences Center at Shreveport
  - Shreveport, Louisiana, Forenede Stater, 71101
    - Ochsner LSU Health Saint Mary's Medical Center
- Maine
  - Augusta, Maine, Forenede Stater, 04330
    - Harold Alfond Center for Cancer Care
  - Biddeford, Maine, Forenede Stater, 04005
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
  - Sanford, Maine, Forenede Stater, 04073
    - MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
  - South Portland, Maine, Forenede Stater, 04106
    - Maine Medical Partners - South Portland
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21229
    - Saint Agnes Hospital
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Randallstown, Maryland, Forenede Stater, 21133
    - Northwest Hospital Center
  - Westminster, Maryland, Forenede Stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
- Michigan
  - Adrian, Michigan, Forenede Stater, 49221
    - Hickman Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Saint Joseph Mercy Hospital
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forenede Stater, 48114
    - Saint Joseph Mercy Brighton
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Canton, Michigan, Forenede Stater, 48188
    - Saint Joseph Mercy Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Chelsea, Michigan, Forenede Stater, 48118
    - Saint Joseph Mercy Chelsea
  - Chelsea, Michigan, Forenede Stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Clarkston, Michigan, Forenede Stater, 48346
    - Hematology Oncology Consultants-Clarkston
  - Clarkston, Michigan, Forenede Stater, 48346
    - Newland Medical Associates-Clarkston
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - East China Township, Michigan, Forenede Stater, 48054
    - Great Lakes Cancer Management Specialists-Doctors Park
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Cancer and Blood Disease Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Trinity Health Grand Rapids Hospital
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Academic Hematology Oncology Specialists
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Michigan Breast Specialists-Grosse Pointe Woods
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - Ascension Borgess Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Hope Cancer Clinic
  - Macomb, Michigan, Forenede Stater, 48044
    - Great Lakes Cancer Management Specialists-Macomb Medical Campus
  - Macomb, Michigan, Forenede Stater, 48044
    - Michigan Breast Specialists-Macomb Township
  - Monroe, Michigan, Forenede Stater, 48162
    - Toledo Clinic Cancer Centers-Monroe
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Norton Shores, Michigan, Forenede Stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Novi, Michigan, Forenede Stater, 48374
    - Ascension Providence Hospitals - Novi
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Pontiac, Michigan, Forenede Stater, 48341
    - 21st Century Oncology-Pontiac
  - Pontiac, Michigan, Forenede Stater, 48341
    - Hope Cancer Center
  - Pontiac, Michigan, Forenede Stater, 48341
    - Newland Medical Associates-Pontiac
  - Reed City, Michigan, Forenede Stater, 49677
    - Spectrum Health Reed City Hospital
  - Saginaw, Michigan, Forenede Stater, 48601
    - Ascension Saint Mary's Hospital
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Southfield, Michigan, Forenede Stater, 48075
    - Ascension Providence Hospitals - Southfield
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Warren, Michigan, Forenede Stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forenede Stater, 48093
    - Great Lakes Cancer Management Specialists-Macomb Professional Building
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Michigan Breast Specialists-Warren
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Aitkin, Minnesota, Forenede Stater, 56431
    - Riverwood Healthcare Center
  - Baxter, Minnesota, Forenede Stater, 56425
    - Essentia Health - Baxter Clinic
  - Brainerd, Minnesota, Forenede Stater, 56401
    - Essentia Health Saint Joseph's Medical Center
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Fairview Ridges Hospital
  - Burnsville, Minnesota, Forenede Stater, 55337
    - Minnesota Oncology - Burnsville
  - Cambridge, Minnesota, Forenede Stater, 55008
    - Cambridge Medical Center
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Deer River, Minnesota, Forenede Stater, 56636
    - Essentia Health - Deer River Clinic
  - Detroit Lakes, Minnesota, Forenede Stater, 56501
    - Essentia Health Saint Mary's - Detroit Lakes Clinic
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Cancer Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Essentia Health Saint Mary's Medical Center
  - Duluth, Minnesota, Forenede Stater, 55805
    - Miller-Dwan Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Ely, Minnesota, Forenede Stater, 55731
    - Essentia Health - Ely Clinic
  - Fergus Falls, Minnesota, Forenede Stater, 56537
    - Lake Region Healthcare Corporation-Cancer Care
  - Fosston, Minnesota, Forenede Stater, 56542
    - Essentia Health - Fosston
  - Fridley, Minnesota, Forenede Stater, 55432
    - Unity Hospital
  - Hibbing, Minnesota, Forenede Stater, 55746
    - Essentia Health Hibbing Clinic
  - International Falls, Minnesota, Forenede Stater, 56649
    - Essentia Health - International Falls Clinic
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Saint John's Hospital - Healtheast
  - Maplewood, Minnesota, Forenede Stater, 55109
    - Minnesota Oncology Hematology PA-Maplewood
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - Minneapolis, Minnesota, Forenede Stater, 55454
    - Health Partners Inc
  - Monticello, Minnesota, Forenede Stater, 55362
    - Monticello Cancer Center
  - Moose Lake, Minnesota, Forenede Stater, 55767
    - Essentia Health - Moose Lake Clinic
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Park Rapids, Minnesota, Forenede Stater, 56470
    - Essentia Health - Park Rapids
  - Princeton, Minnesota, Forenede Stater, 55371
    - Fairview Northland Medical Center
  - Robbinsdale, Minnesota, Forenede Stater, 55422
    - North Memorial Medical Health Center
  - Saint Cloud, Minnesota, Forenede Stater, 56303
    - Coborn Cancer Center at Saint Cloud Hospital
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Sandstone, Minnesota, Forenede Stater, 55072
    - Essentia Health Sandstone
  - Shakopee, Minnesota, Forenede Stater, 55379
    - Saint Francis Regional Medical Center
  - Stillwater, Minnesota, Forenede Stater, 55082
    - Lakeview Hospital
  - Virginia, Minnesota, Forenede Stater, 55792
    - Essentia Health Virginia Clinic
  - Waconia, Minnesota, Forenede Stater, 55387
    - Ridgeview Medical Center
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
  - Woodbury, Minnesota, Forenede Stater, 55125
    - Minnesota Oncology Hematology PA-Woodbury
  - Wyoming, Minnesota, Forenede Stater, 55092
    - Fairview Lakes Medical Center
- Missouri
  - Ballwin, Missouri, Forenede Stater, 63011
    - Saint Louis Cancer and Breast Institute-Ballwin
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Southeast Cancer Center
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Joplin, Missouri, Forenede Stater, 64804
    - Freeman Health System
  - Joplin, Missouri, Forenede Stater, 64804
    - Mercy Hospital Joplin
  - Rolla, Missouri, Forenede Stater, 65401
    - Delbert Day Cancer Institute at PCRMC
  - Rolla, Missouri, Forenede Stater, 65401
    - Mercy Clinic-Rolla-Cancer and Hematology
  - Saint Joseph, Missouri, Forenede Stater, 64506
    - Heartland Regional Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - Saint Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - Saint Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - Saint Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - Saint Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - Saint Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - Saint Louis, Missouri, Forenede Stater, 63109
    - Saint Louis Cancer and Breast Institute-South City
  - Saint Louis, Missouri, Forenede Stater, 63125
    - Veteran's Affairs Medical Center - Saint Louis
  - Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65807
    - CoxHealth South Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - Missouri Baptist Outpatient Center-Sunset Hills
  - Washington, Missouri, Forenede Stater, 63090
    - Mercy Hospital Washington
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Billings, Montana, Forenede Stater, 59101
    - Saint Vincent Healthcare
  - Billings, Montana, Forenede Stater, 59102
    - Saint Vincent Frontier Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Butte, Montana, Forenede Stater, 59701
    - Saint James Community Hospital and Cancer Treatment Center
  - Great Falls, Montana, Forenede Stater, 59405
    - Great Falls Clinic
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
  - Missoula, Montana, Forenede Stater, 59802
    - Saint Patrick Hospital - Community Hospital
- Nebraska
  - Bellevue, Nebraska, Forenede Stater, 68123
    - Nebraska Medicine-Bellevue
  - Grand Island, Nebraska, Forenede Stater, 68803
    - CHI Health Saint Francis
  - Omaha, Nebraska, Forenede Stater, 68114
    - Nebraska Methodist Hospital
  - Omaha, Nebraska, Forenede Stater, 68198
    - University of Nebraska Medical Center
  - Omaha, Nebraska, Forenede Stater, 68118
    - Nebraska Medicine-Village Pointe
  - Omaha, Nebraska, Forenede Stater, 68114
    - Oncology Associates PC
- Nevada
  - Carson City, Nevada, Forenede Stater, 89703
    - Carson Tahoe Regional Medical Center
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - OptumCare Cancer Care at Seven Hills
  - Henderson, Nevada, Forenede Stater, 89052
    - Cancer and Blood Specialists-Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Las Vegas Cancer Center-Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - Comprehensive Cancer Centers of Nevada-Southeast Henderson
  - Henderson, Nevada, Forenede Stater, 89074
    - GenesisCare USA - Henderson
  - Henderson, Nevada, Forenede Stater, 89052
    - Comprehensive Cancer Centers of Nevada-Horizon Ridge
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Green Valley
  - Henderson, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pebble
  - Henderson, Nevada, Forenede Stater, 89074
    - Urology Specialists of Nevada - Green Valley
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Summerlin Hospital Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89109
    - Sunrise Hospital and Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Radiation Oncology Centers of Nevada Central
  - Las Vegas, Nevada, Forenede Stater, 89109
    - GenesisCare USA - Las Vegas
  - Las Vegas, Nevada, Forenede Stater, 89119
    - Radiation Oncology Centers of Nevada Southeast
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Comprehensive Cancer Centers of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89128
    - OptumCare Cancer Care at MountainView
  - Las Vegas, Nevada, Forenede Stater, 89135
    - Alliance for Childhood Diseases/Cure 4 the Kids Foundation
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada - Town Center
  - Las Vegas, Nevada, Forenede Stater, 89144
    - Comprehensive Cancer Centers of Nevada-Summerlin
  - Las Vegas, Nevada, Forenede Stater, 89148
    - Comprehensive Cancer Centers of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89148
    - OptumCare Cancer Care at Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89169
    - Comprehensive Cancer Centers of Nevada - Central Valley
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
  - Las Vegas, Nevada, Forenede Stater, 89128
    - GenesisCare USA - Vegas Tenaya
  - Las Vegas, Nevada, Forenede Stater, 89148-2405
    - Las Vegas Cancer Center-Medical Center
  - Las Vegas, Nevada, Forenede Stater, 89148
    - GenesisCare USA - Fort Apache
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Ann M Wierman MD LTD
  - Las Vegas, Nevada, Forenede Stater, 89074
    - Las Vegas Urology - Pecos
  - Las Vegas, Nevada, Forenede Stater, 89102
    - Desert West Surgery
  - Las Vegas, Nevada, Forenede Stater, 89103
    - Hope Cancer Care of Nevada
  - Las Vegas, Nevada, Forenede Stater, 89106
    - Urology Specialists of Nevada - Central
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Prostate Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Las Vegas Urology - Sunset
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Cathedral Rock
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Las Vegas Urology - Smoke Ranch
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Urology Specialists of Nevada - Northwest
  - Las Vegas, Nevada, Forenede Stater, 89169
    - University Cancer Center
  - Las Vegas, Nevada, Forenede Stater, 89113
    - Urology Specialists of Nevada - Southwest
  - Pahrump, Nevada, Forenede Stater, 89048
    - Hope Cancer Care of Nevada-Pahrump
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89503
    - Saint Mary's Regional Medical Center
  - Reno, Nevada, Forenede Stater, 89509
    - Radiation Oncology Associates
- New Hampshire
  - Concord, New Hampshire, Forenede Stater, 03301
    - New Hampshire Oncology Hematology PA-Concord
  - Manchester, New Hampshire, Forenede Stater, 03103
    - Solinsky Center for Cancer Care
- New Jersey
  - Mullica Hill, New Jersey, Forenede Stater, 08062
    - Inspira Medical Center Mullica Hill
- New York
  - Auburn, New York, Forenede Stater, 13021
    - Hematology Oncology Associates of Central New York-Auburn
  - Bronx, New York, Forenede Stater, 10468
    - James J Peters VA Medical Center
  - East Syracuse, New York, Forenede Stater, 13057
    - Hematology Oncology Associates of Central New York-East Syracuse
  - Glens Falls, New York, Forenede Stater, 12801
    - Glens Falls Hospital
  - New York, New York, Forenede Stater, 10032
    - NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
  - New York, New York, Forenede Stater, 10065
    - NYP/Weill Cornell Medical Center
  - Syracuse, New York, Forenede Stater, 13215
    - Hematology Oncology Associates of Central New York-Onondaga Hill
  - Valley Stream, New York, Forenede Stater, 11580
    - South Nassau Cancer Center
- North Carolina
  - Asheville, North Carolina, Forenede Stater, 28803
    - AdventHealth Infusion Center Asheville
  - Clayton, North Carolina, Forenede Stater, 27520
    - Johnston Health Clayton
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clyde, North Carolina, Forenede Stater, 28721
    - AdventHealth Infusion Center Haywood
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Henderson, North Carolina, Forenede Stater, 27536
    - Maria Parham Hospital
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - AdventHealth Hendersonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Kenansville, North Carolina, Forenede Stater, 28349
    - Vidant Oncology-Kenansville
  - Kinston, North Carolina, Forenede Stater, 28501
    - Vidant Oncology-Kinston
  - Laurinburg, North Carolina, Forenede Stater, 28352
    - Scotland Memorial Hospital-Laurinburg Cancer Center
  - Lumberton, North Carolina, Forenede Stater, 28358
    - Southeastern Regional Medical Center
  - Richlands, North Carolina, Forenede Stater, 28574
    - Vidant Oncology-Richlands
  - Smithfield, North Carolina, Forenede Stater, 27577
    - Johnston Memorial Hospital
  - Weaverville, North Carolina, Forenede Stater, 28787
    - AdventHealth Infusion Center Weaverville
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58103
    - Essentia Health Cancer Center-South University Clinic
  - Jamestown, North Dakota, Forenede Stater, 58401
    - Essentia Health - Jamestown Clinic
- Ohio
  - Beavercreek, Ohio, Forenede Stater, 45431
    - Indu and Raj Soin Medical Center
  - Boardman, Ohio, Forenede Stater, 44512
    - Saint Elizabeth Boardman Hospital
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Centerville, Ohio, Forenede Stater, 45459
    - Dayton Physicians LLC-Miami Valley South
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cincinnati, Ohio, Forenede Stater, 45236
    - Oncology Hematology Care Inc-Kenwood
  - Columbus, Ohio, Forenede Stater, 43214
    - Riverside Methodist Hospital
  - Columbus, Ohio, Forenede Stater, 43210
    - Ohio State University Comprehensive Cancer Center
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43228
    - Doctors Hospital
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Columbus, Ohio, Forenede Stater, 43215
    - Grant Medical Center
  - Columbus, Ohio, Forenede Stater, 43222
    - Mount Carmel Health Center West
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physician LLC-Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Delaware, Ohio, Forenede Stater, 43015
    - Delaware Health Center-Grady Cancer Center
  - Delaware, Ohio, Forenede Stater, 43015
    - Grady Memorial Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Blanchard Valley Hospital
  - Findlay, Ohio, Forenede Stater, 45840
    - Armes Family Cancer Center
  - Findlay, Ohio, Forenede Stater, 45840
    - Orion Cancer Care
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Franklin, Ohio, Forenede Stater, 45005
    - Dayton Physicians LLC-Atrium
  - Greenville, Ohio, Forenede Stater, 45331
    - Wayne Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Dayton Physicians LLC-Wayne
  - Grove City, Ohio, Forenede Stater, 43123
    - Mount Carmel Grove City Hospital
  - Grove City, Ohio, Forenede Stater, 43123
    - Zangmeister Center Grove City
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Kettering, Ohio, Forenede Stater, 45409
    - Greater Dayton Cancer Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Marietta, Ohio, Forenede Stater, 45750
    - Marietta Memorial Hospital
  - Maumee, Ohio, Forenede Stater, 43537
    - Toledo Clinic Cancer Centers-Maumee
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - New Albany, Ohio, Forenede Stater, 43054
    - Mount Carmel New Albany Surgical Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Toledo, Ohio, Forenede Stater, 43608
    - Saint Vincent Mercy Medical Center
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Toledo, Ohio, Forenede Stater, 43614
    - University of Toledo
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Troy, Ohio, Forenede Stater, 45373
    - Dayton Physicians LLC - Troy
  - Warren, Ohio, Forenede Stater, 44484
    - Saint Joseph Warren Hospital
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Wright-Patterson Air Force Base, Ohio, Forenede Stater, 45433
    - Wright-Patterson Medical Center
  - Youngstown, Ohio, Forenede Stater, 44501
    - Saint Elizabeth Youngstown Hospital
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
- Oregon
  - Baker City, Oregon, Forenede Stater, 97814
    - Saint Alphonsus Medical Center-Baker City
  - Corvallis, Oregon, Forenede Stater, 97330
    - Good Samaritan Hospital
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Medical Center-Ontario
- Pennsylvania
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Chadds Ford, Pennsylvania, Forenede Stater, 19317
    - Christiana Care Health System-Concord Health Center
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - WellSpan Medical Oncology and Hematology
  - Collegeville, Pennsylvania, Forenede Stater, 19426
    - Main Line Health Center-Collegeville
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Community Hospital
  - Exton, Pennsylvania, Forenede Stater, 19341
    - Main Line Health Center-Exton
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Hanover, Pennsylvania, Forenede Stater, 17331
    - Cherry Tree Cancer Center
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Jefferson Torresdale Hospital
  - Sayre, Pennsylvania, Forenede Stater, 18840
    - Guthrie Medical Group PC-Robert Packer Hospital
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Hospital
  - York, Pennsylvania, Forenede Stater, 17403
    - Cancer Care Associates of York
- Rhode Island
  - Warwick, Rhode Island, Forenede Stater, 02886
    - Kent Hospital
- South Carolina
  - Bluffton, South Carolina, Forenede Stater, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Boiling Springs, South Carolina, Forenede Stater, 29316
    - Prisma Health Cancer Institute - Spartanburg
  - Easley, South Carolina, Forenede Stater, 29640
    - Prisma Health Cancer Institute - Easley
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Faris
  - Greenville, South Carolina, Forenede Stater, 29615
    - Prisma Health Cancer Institute - Eastside
  - Greenville, South Carolina, Forenede Stater, 29605
    - Prisma Health Cancer Institute - Butternut
  - Greer, South Carolina, Forenede Stater, 29650
    - Prisma Health Cancer Institute - Greer
  - Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
    - South Carolina Cancer Specialists PC
  - Seneca, South Carolina, Forenede Stater, 29672
    - Prisma Health Cancer Institute - Seneca
- Texas
  - Bryan, Texas, Forenede Stater, 77802
    - Saint Joseph Regional Cancer Center
  - Dallas, Texas, Forenede Stater, 75216
    - Dallas VA Medical Center
- Virginia
  - Chesapeake, Virginia, Forenede Stater, 23320
    - Cancer Specialists of Tidewater Limited
  - Gloucester, Virginia, Forenede Stater, 23061
    - Peninsula Cancer Institute-Gloucester
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - Mechanicsville, Virginia, Forenede Stater, 23116
    - Bon Secours Memorial Regional Medical Center
  - Midlothian, Virginia, Forenede Stater, 23114
    - Bon Secours Saint Francis Medical Center
  - Midlothian, Virginia, Forenede Stater, 23113
    - Bon Secours Westchester Emergency Center
  - Newport News, Virginia, Forenede Stater, 23601
    - Peninsula Cancer Institute-Newport News
  - Norfolk, Virginia, Forenede Stater, 23505
    - Bon Secours DePaul Medical Center
  - Onancock, Virginia, Forenede Stater, 23417
    - Riverside Shore Cancer Center
  - Portsmouth, Virginia, Forenede Stater, 23707
    - Bon Secours Maryview Medical Center
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University/Massey Cancer Center
  - Richmond, Virginia, Forenede Stater, 23229
    - Virginia Cancer Institute
  - Richmond, Virginia, Forenede Stater, 23226
    - Bon Secours Saint Mary's Hospital
  - Richmond, Virginia, Forenede Stater, 23230
    - Bon Secours Cancer Institute at Reynolds Crossing
  - South Hill, Virginia, Forenede Stater, 23970
    - VCU Community Memorial Health Center
  - Suffolk, Virginia, Forenede Stater, 23435
    - Cancer Specialists of Tidewater-Suffolk
  - Suffolk, Virginia, Forenede Stater, 23435
    - Bon Secours Health Center at Harbour View
  - Virginia Beach, Virginia, Forenede Stater, 23454
    - Peninsula Cancer Institute-Cancer Specialists of Tidewater
  - Williamsburg, Virginia, Forenede Stater, 23185
    - Peninsula Cancer Institute-Williamsburg
- Washington
  - Bellevue, Washington, Forenede Stater, 98004
    - Overlake Medical Center
  - Edmonds, Washington, Forenede Stater, 98026
    - Swedish Cancer Institute-Edmonds
  - Issaquah, Washington, Forenede Stater, 98029
    - Swedish Cancer Institute-Issaquah
  - Kennewick, Washington, Forenede Stater, 99336
    - Kadlec Clinic Hematology and Oncology
  - Port Townsend, Washington, Forenede Stater, 98368
    - Jefferson Healthcare
  - Renton, Washington, Forenede Stater, 98055
    - Valley Medical Center
  - Seattle, Washington, Forenede Stater, 98107
    - Swedish Medical Center-Ballard Campus
  - Seattle, Washington, Forenede Stater, 98122
    - Swedish Medical Center-First Hill
  - Seattle, Washington, Forenede Stater, 98122-5711
    - Swedish Medical Center-Cherry Hill
  - Walla Walla, Washington, Forenede Stater, 99362
    - Providence Saint Mary Regional Cancer Center
  - Yakima, Washington, Forenede Stater, 98902
    - North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
- West Virginia
  - Bridgeport, West Virginia, Forenede Stater, 26330
    - United Hospital Center
  - Martinsburg, West Virginia, Forenede Stater, 25401
    - WVUH-Berkely Medical Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Parkersburg, West Virginia, Forenede Stater, 26101
    - Camden Clark Medical Center
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Duluth Clinic Ashland
  - Ashland, Wisconsin, Forenede Stater, 54806
    - Northwest Wisconsin Cancer Center
  - Chippewa Falls, Wisconsin, Forenede Stater, 54729
    - Marshfield Clinic-Chippewa Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Marshfield Medical Center-EC Cancer Center
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - Mayo Clinic Health System-Eau Claire Clinic
  - Hayward, Wisconsin, Forenede Stater, 54843
    - Essentia Health-Hayward Clinic
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Mayo Clinic Health System-Franciscan Healthcare
  - Ladysmith, Wisconsin, Forenede Stater, 54848
    - Marshfield Clinic - Ladysmith Center
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Medical Center-Marshfield
  - Menomonee Falls, Wisconsin, Forenede Stater, 53051
    - Froedtert Menomonee Falls Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53226
    - Medical College of Wisconsin
  - Minocqua, Wisconsin, Forenede Stater, 54548
    - Marshfield Clinic-Minocqua Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - New Richmond, Wisconsin, Forenede Stater, 54017
    - Cancer Center of Western Wisconsin
  - Oak Creek, Wisconsin, Forenede Stater, 53154
    - Drexel Town Square Health Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Rice Lake, Wisconsin, Forenede Stater, 54868
    - Marshfield Medical Center-Rice Lake
  - Spooner, Wisconsin, Forenede Stater, 54801
    - Essentia Health-Spooner Clinic
  - Stevens Point, Wisconsin, Forenede Stater, 54482
    - Marshfield Medical Center-River Region at Stevens Point
  - Superior, Wisconsin, Forenede Stater, 54880
    - Essentia Health Saint Mary's Hospital - Superior
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Marshfield Clinic-Wausau Center
  - West Bend, Wisconsin, Forenede Stater, 53095
    - Froedtert West Bend Hospital/Kraemer Cancer Center
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Medical Center - Weston
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Marshfield Clinic - Wisconsin Rapids Center
- Wyoming
  - Cheyenne, Wyoming, Forenede Stater, 82001
    - Cheyenne Regional Medical Center-West
  - Cody, Wyoming, Forenede Stater, 82414
    - Billings Clinic-Cody
  - Sheridan, Wyoming, Forenede Stater, 82801
    - Welch Cancer Center

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

70 år og ældre (Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Dokumentation af sygdom: Histologisk eller cytologisk diagnose af ikke-småcellet lungekræft (adenokarcinom). Stadie IV eller tilbagevendende metastatisk ikke-småcellet lungekræft. Ingen planlagt påbegyndelse af endelig (potentielt helbredende) samtidig kemo-stråling
Planlægger at påbegynde behandling med MK-3475 (pembrolizumab) inden for 14 dage efter registrering, med eller uden kombinationskemoterapi. Den behandlende læge anser pembrolizumab som passende og planlægger at fortsætte med en af følgende behandlingsplaner:
- MK-3475 (pembrolizumab) 200 mg IV flad dosis hver 21. dag eller 400 mg IV hver 42. dag.
- MK-3475 (pembrolizumab) 200 mg IV eller 400 mg IV + carboplatin areal under kurven (AUC) = 5 + pemetrexed 500 mg/m^2 (20 % reduktion af kemoterapidosis er tilladt efter den behandlende læges skøn)
Patienter vil være udelukket, hvis de har en autoimmun lidelse, er post-organtransplantation eller modtager igangværende immunsuppressionsbehandling
Forudgående adjuverende behandling er tilladt og skal være afsluttet mindst 6 måneder før registrering
Ingen planlagt stråling eller anden kræftbehandling i de 3 måneder efter registrering
Ingen ubehandlede hjernemetastaser. Patienter skal være fri for kortikosteroider og asymptomatiske ved registrering
Absolut neutrofiltal (ANC) >= 1500/mm^3 (1,5 x 10^9/L)
Blodpladeantal: >= 100.000/mm^3 (100 x 10^9/L)
Kreatinin >= 30 ml/min* for patienter indskrevet til pembrolizumab alene og > 45 ml/min for patienter indskrevet til kemoterapi + pembrolizumab
* Beregnet ved hjælp af Cockcroft-Gault formlen
Total serumbilirubin =< 1,5 øvre normalgrænse (ULN) (< 3 ULN hvis Gilberts sygdom)
Aspartataminotransferase (AST) og/eller alaninaminotransferase (ALT) =< 3 x ULN (=< 5,0 x ULN, hvis levermetastaser er til stede)
Alkalisk fosfatase =< 2,5 x ULN (=< 5 x ULN, hvis knogle- eller levermetastaser er til stede) Sprog: Patienterne skal kunne tale og forstå engelsk for at kunne gennemføre de obligatoriske patientgennemførte målinger

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Ikke-randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Gruppe A (pembrolizumab) Patienterne får pembrolizumab IV over 30 minutter på dag 1. Cykler gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Andet: Livskvalitetsvurdering Hjælpestudier Andet: Spørgeskemaadministration Hjælpestudier Medicin: Pembrolizumab Givet IV Andet: Omfattende geriatrisk vurdering Hjælpestudier
Eksperimentel: Gruppe B (pembrolizumab, pemetrexed, carboplatin) Patienterne får pembrolizumab IV over 30 minutter, pemetrexed IV over 10 minutter og carboplatin IV i henhold til institutionelle retningslinjer på dag 1. Cykler gentages hver 21. dag i fravær af sygdomsprogression eller uacceptabel toksicitet.	Medicin: Carboplatin Givet IV Andet: Livskvalitetsvurdering Hjælpestudier Andet: Spørgeskemaadministration Hjælpestudier Medicin: Pembrolizumab Givet IV Medicin: Pemetrexed Givet IV Andet: Omfattende geriatrisk vurdering Hjælpestudier

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Forekomst af klasse 3 eller værre bivirkninger efter registrering Tidsramme: Op til 7 dage efter behandlingsdagen, op til 6 måneder	Vurderet af National Cancer Institute Common Terminology kriterier i bivirkninger Version 5.0. Andelen af patienterne oplever klasse 3 eller værre bivirkninger (AE'er) opsummeres med frekvens og procentdel sammen med et 95% konfidensinterval (CI) separat efter type terapi (monoterapi eller kombinationsterapi) samt kombinerer de to kohorter. Alle andre individuelle AE'er vil blive analyseret på en sonderende og hypotese -genereringsmåde; inklusive og ikke begrænset til multi-variate logistiske regressionsmodeller i betragtning af baseline-demografien og tilstedeværelsen/fraværet af AE.	Op til 7 dage efter behandlingsdagen, op til 6 måneder

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Samlet overlevelse (OS) Tidsramme: Fra undersøgelsesregistrering til død eller den sidste opfølgning, alt efter hvad der sker først, vurderet op til 3 år	Opsummeres ved hjælp af Kaplan-Meier-estimatoren, separat ved monoterapi eller kombinationsterapi såvel som af den kombinerede kohort.	Fra undersøgelsesregistrering til død eller den sidste opfølgning, alt efter hvad der sker først, vurderet op til 3 år
Livskvalitet (QOL): Lineær analog selvvurdering [LASA] Spørgeskema Tidsramme: Op til 9 uger	Den overordnede livskvalitetsresultat (det første spørgsmål om den lineære analog selvvurdering [LASA] spørgeskema) på hvert tidspunkt samt ændring fra baseline opsummeres med gennemsnit (standardafvigelse), median (rækkevidde) sammen med et langsgående grund. Den median livskvalitet (QOL) ændres fra baseline sammen med et 95% konfidensinterval (CI) vil blive estimeret ved hjælp af Hodges-Lehmann-metoden. Den samlede livskvalitets score måles på en skala fra 0-10, hvor højere er bedre.	Op til 9 uger
Omfattende geriatrisk vurderingsrisiko score Tidsramme: Ved baseline. I henhold til protokollens afsnit 13.5 ville omfattende geriatrisk vurdering blive undersøgt kombineret af ARM.	Den geriatriske risikoscore, målt som lav, medium eller høj, vil blive sammenfattet i en 3x2 frekvenstabel med bivirkninger.	Ved baseline. I henhold til protokollens afsnit 13.5 ville omfattende geriatrisk vurdering blive undersøgt kombineret af ARM.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Alliance for Clinical Trials in Oncology

Samarbejdspartnere

National Cancer Institute (NCI)

Efterforskere

Studiestol: Aminah Jatoi, MD, Mayo Clinic

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

16. november 2020

Primær færdiggørelse (Faktiske)

31. oktober 2023

Studieafslutning (Anslået)

31. maj 2027

Datoer for studieregistrering

Først indsendt

19. august 2020

Først indsendt, der opfyldte QC-kriterier

28. august 2020

Først opslået (Faktiske)

31. august 2020

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

13. juni 2025

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

4. juni 2025

Sidst verificeret

1. juni 2025

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

A171901
UG1CA189823 (U.S. NIH-bevilling/kontrakt)
NCI-2020-00544 (Registry Identifier: NCI Clinical Trial Reporting Program)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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Taichung Veterans General Hospital

Afsluttet

Kræftterapi-relateret kardial dysfunktion forbundet med EGFR-TKI'er i fremskreden EGFR-muteret ikke-småcellet lungekræft

Kardiotoksicitet | Non-Small Cell Lungecancer (MeSH Term: Carcinoma, Non-Small-Cell Lung) | Lægemiddelrelaterede bivirkninger og uønskede reaktioner (MeSH-betegnelse) | Egfr Tyrosinkinasehæmmer

Taiwan
Fondazione del Piemonte per l'Oncologia

Rekruttering

En undersøgelse af biologiske, genetiske og konstitutionelle faktorer samt ikke-invasiv overvågning til vurdering af personlige kræftrisici (PRO-ACTIVE)

Brystkræft | Livmoderhalskræft | Colo-rektal cancer | Melanom (hudkræft) | Non-Small Cell Lungecancer (MeSH Term: Carcinoma, Non-Small-Cell Lung)

Italien

Kliniske forsøg med Carboplatin

Eisai Inc.

Afsluttet

En dosisfindende undersøgelse af E7389 i kombination med carboplatin hos patienter med solide tumorer

Kræft

Forenede Stater, Østrig, Indien
Tang-Du Hospital

Rekruttering

Nimotuzumab kombineret med Toripalimab og kemoterapi til lokal avanceret tonsilkræft

Hoved- og nakkekræft

Kina
NHS Greater Glasgow and Clyde

Afsluttet

Carboplatin til behandling af patienter med stadium IC-IV ovarie-, æggeleder- eller primær peritoneal cancer

Livmoderhalskræft | Æggelederkræft | Primær peritoneal kræft

Det Forenede Kongerige, Australien, New Zealand
Duke University

Afsluttet

Carboplatin hos patienter med progressive gliomer

Tumorer i hjernen og centralnervesystemet

Forenede Stater, Canada
Shanghai Pulmonary Hospital, Shanghai, China

Ikke rekrutterer endnu

Undersøgelse af effektiviteten og sikkerheden af JSKN016 som neoadjuvant terapi hos patienter med resektabel ikke-småcellet lungekræft i stadium II-III

NSCLC trin II

Kina
Zhejiang Cancer Hospital

Rekruttering

Effekt og sikkerhed af Distamab Vedotin kombineret med Carboplatin til avanceret æggestokkræft i første behandlingslinje

Livmoderhalskræft | HER2

Kina
Samyang Biopharmaceuticals Corporation

Afsluttet

Bestem MTD, evaluer effektiviteten og sikkerheden af Genexol®-PM Plus Carboplatin med avanceret ovariecancer

Livmoderhalskræft
Shuangyue Liu

Ikke rekrutterer endnu

Potentiel multicenter enkeltarmsundersøgelse: AK112 + NAB-PACLITAXEL/CARBOPLATIN NEOADJUVANT FOR TNBC

Brystkræft - Kvinde
H. Lee Moffitt Cancer Center and Research Institute
National Cancer Institute (NCI)

Afsluttet

BMS-188797 and Carboplatin in Treating Patients With Advanced Nonhematologic Cancer

Uspecificeret fast tumor hos voksne, protokolspecifik

Forenede Stater
Eli Lilly and Company

Afsluttet

ALIMTA(Pemetrexed)/Cisplatin og ALIMTA(Pemetrexed)/Carboplatin i omfattende småcellet lungekræft.

Lungeneoplasmer

Forenede Stater

Test af virkningerne af MK-3475 (Pembrolizumab) med eller uden den sædvanlige kemoterapibehandling til patienter i alderen 70 år og ældre med avanceret ikke-småcellet lungekræft

Ældre ikke-småcellet lungekræftpatienter (>/= 70 år) behandlet med First-Line MK-3475 (Pembrolizumab)+/- Kemoterapi (Onkologs/Patientens valg)

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

produkt fremstillet i og eksporteret fra U.S.A.

Kliniske forsøg med Metastatisk lunge ikke-småcellet karcinom

Kliniske forsøg med Carboplatin

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Hong Kong

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer