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ZEUS - En forskningsundersøgelse for at se på, hvordan Ziltivekimab virker sammenlignet med placebo hos mennesker med hjerte-kar-sygdomme, kronisk nyresygdom og betændelse (ZEUS)

7. april 2026 opdateret af: Novo Nordisk A/S

ZEUS - Effekter af Ziltivekimab versus placebo på kardiovaskulære resultater hos deltagere med etableret aterosklerotisk kardiovaskulær sygdom, kronisk nyresygdom og systemisk inflammation

Denne undersøgelse er udført for at se, om ziltivekimab reducerer risikoen for at få kardiovaskulære hændelser (for eksempel hjerteanfald og slagtilfælde) hos mennesker med hjerte-kar-sygdomme, kronisk nyresygdom og betændelse.

Deltagerne vil enten få ziltivekimab (aktiv medicin) eller placebo (en dummy medicin, som ikke har nogen effekt på kroppen). Dette er kendt som studiemedicin. Hvilken behandling deltagerne får afgøres tilfældigt. Deltagernes chance for at få ziltivekimab eller placebo er den samme.

Ziltivekimab er endnu ikke godkendt i noget land eller region i verden. Det er en ny medicin, læger ikke kan ordinere.

Deltagerne får studiemedicinen i en fyldt sprøjte. Deltagerne skal bruge den fyldte sprøjte til at injicere undersøgelsesmedicinen i en hudfold én gang om måneden.

Undersøgelsen forventes at vare i op til 4 år. Deltagerne vil have op til 20 klinikbesøg. Deltagerne vil få taget blod- og urinprøver ved de fleste klinikbesøg.

Deltagerne vil få deres hjerte undersøgt ved hjælp af lydbølger (ekkokardiografi) og elektroder (elektrokardiogram).

Kvinder kan ikke deltage, hvis de er gravide, ammer eller planlægger at blive gravide i studieperioden.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

6200

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Buenos Aires, Argentina, C1425AGC
    - Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
  - Buenos Aires, Argentina, B6000BHA
    - Centro Medico Lebensohn
  - CABA, Argentina, C1120AAC
    - Centro Medico Viamonte SRL
  - Capital Federal, Argentina, C1431FWO
    - Centro de Educación Médica e Investigaciones Clínicas Saaved
  - Ciudad Autónoma de Buenos Aire, Argentina, 1425
    - Cardiología Palermo Duplicate
  - Córdoba, Argentina, X5003DCE
    - Instituto Médico DAMIC
  - Quilmes - Buenos Aires, Argentina, B1878DVB
    - Instituto Medico CER
  - San Miguel de Tucumán, Tucumán., Argentina, T4000
    - Investigaciones Clínicas Tucumán
  - San Nicolás, Argentina, B2900
    - Instituto de Investigaciones Clinicas San Nicolas
- Buenos Aires
  - CABA, Buenos Aires, Argentina, C1128 AAF
    - Mautalen Salud e Investigación
  - CABA, Buenos Aires, Argentina, C1440CFD
    - CEMEDIC
  - CABA, Buenos Aires, Argentina, C1213
    - Sanatorio Finochietto
  - CABA, Buenos Aires, Argentina, C1428ART
    - Instituto Cardiovascular Buenos Aires
  - La Plata, Buenos Aires, Argentina, B 1900AXI
    - Hospital Italiano de La Plata
  - Mar del Plata, Buenos Aires, Argentina, B7600GNY
    - Centro de Investigaciones Médicas Clínica de Fracturas y Or
  - Mar del Plata, Buenos Aires, Argentina, B7600GNY
    - Centro de Investigaciones Médicas Mar del Plata
Australien
- Australian Capital Territory
  - Garran, Australian Capital Territory, Australien, 2605
    - Canberra Hospital
  - Garran, Australian Capital Territory, Australien, 2605
    - The Canberra Hospital_Garran
- New South Wales
  - Gosford, New South Wales, Australien, 2250
    - Gosford Renal Research
  - Kogarah, New South Wales, Australien, 2217
    - St George Hospital
  - St Leonards, New South Wales, Australien, 2065
    - Royal North Shore Hospital
  - Westmead, New South Wales, Australien, 2145
    - Westmead Applied Research Centre
  - Wollongong, New South Wales, Australien, 2500
    - Illawarra Heart Health Centre
- Queensland
  - Birtinya, Queensland, Australien, 4575
    - Sunshine Coast University Hospital
  - Milton, Queensland, Australien, 4064
    - Core Research Group
- South Australia
  - Adelaide, South Australia, Australien, 5000
    - Nightingale Research
  - Adelaide, South Australia, Australien, 5000
    - Royal Adelaide Hospital Cardiovascular Clinical Trials
  - Adelaide, South Australia, Australien, 5000
    - Royal Adelaide Hospital - Cardiology Department
  - Leabrook, South Australia, Australien, 5068
    - Advara HeartCare Leabrook
  - Leabrook, South Australia, Australien, 5068
    - HeartCare SA
- Tasmania
  - Hobart, Tasmania, Australien, 7000
    - Royal Hobart Hospital
- Victoria
  - Clayton, Victoria, Australien, 3168
    - Monash Health Heart
  - Fitzroy, Victoria, Australien, 3065
    - St Vincent's Hospital_Fitzroy_0
  - Geelong, Victoria, Australien, 3220
    - Geelong Cardiology Research Unit
  - Reservoir, Victoria, Australien, 3073
    - Melbourne Renal Research Group
  - St Albans, Victoria, Australien, 3021
    - Sunshine Hospital
  - St Albans, Victoria, Australien, 3021
    - Sunshine Hospital - Western Centre for Health Research and Education
  - Traralagon, Victoria, Australien, 3844
    - Latrobe Regional Hospital - Research Unit
- Western Australia
  - Joondalup, Western Australia, Australien, 6027
    - Advara HeartCare Joondalup
  - Joondalup, Western Australia, Australien, 6027
    - HeartCare WA (Joondalup)
Belgien
- - Aalst, Belgien, 9300
    - AZORG Aalst - Moorselbaan
  - Bonheiden, Belgien, 2820
    - Imeldaziekenhuis - Bonheiden - Department of Endocrinology
  - Brasschaat, Belgien, 2930
    - AZ Klina - Brasschaat - Cardiology
  - Bruges, Belgien, 8000
    - AZ Sint-Jan - Campus Brugge_Brugge
  - Bruges, Belgien, 8000
    - AZ Sint-Jan - Campus Brugge
  - Genk, Belgien, 3600
    - Ziekenhuis Oost-Limburg AV - Cardiology
  - Genk, Belgien, 3600
    - Ziekenhuis Oost Limburg - Cardiology
  - Kortrijk, Belgien, 8500
    - AZ Groeninge - Kortrijk - Cardiology
  - Liège, Belgien, 4000
    - CHR de la Citadelle
  - Mechelen, Belgien, 2800
    - AZ Sint-Maarten Mechelen - Cardiology
  - Ostend, Belgien, 8400
    - AZ OOSTENDE (Campus DAMIAAN)
Brasilien
- - Porto Alegre/ RS, Brasilien, 90035-074
    - Irmandade da Santa Casa de Misericordia de Porto Alegre
  - Salvador, Brasilien, 41810-011
    - HBA S/A Assistência Médica e Hospitalar
  - São Bernardo Do Campo/SP, Brasilien, 09715-090
    - CEMEC - Centro Multidisciplinar de Estudos Clínicos
  - São Paulo - SP, Brasilien, 04038-002
    - Centro de Diabetes e Obesidade - HRim e Hipertensao
- Espírito Santo
  - Vitória, Espírito Santo, Brasilien, 29055-450
    - Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo
- Federal District
  - Brasília, Federal District, Brasilien, 70390-700
    - Hospital do Coração do Brasil
- Minas Gerais
  - Belo Horizonte, Minas Gerais, Brasilien, 30110-934
    - Hospital Felicio Rocho
  - Uberlândia, Minas Gerais, Brasilien, 38400-500
    - Eurolatino Medical Research Center
- Paraná
  - Curitiba, Paraná, Brasilien, 80730-150
    - Núcleo de Pesquisa Clínica S/S
  - Curitiba, Paraná, Brasilien, 80440-020
    - Instituto Pró-Renal Brasil
- Santa Catarina
  - Blumenau, Santa Catarina, Brasilien, 89020-430
    - AngioCor Blumenau
- São Paulo
  - Campinas, São Paulo, Brasilien, 13060-080
    - Instituto de Pesquisa clinica de Campinas
  - Campinas, São Paulo, Brasilien, 13092-133
    - i9 Pesquisas Clínicas
  - Campinas, São Paulo, Brasilien, 13060-803
    - PUCCAMP - Hospital e Maternidade Celso Pierro
  - Santo André, São Paulo, Brasilien, 09090-790
    - Praxis Pesquisa Médica
  - São José do Rio Preto, São Paulo, Brasilien, 15090-000
    - CIP Centro Integrado de Pesquisas do Hospital de Base
  - São Paulo, São Paulo, Brasilien, 01228-000
    - CPQuali Pesquisa Clinica Ltda
  - São Paulo, São Paulo, Brasilien, 01409-902
    - Impar Servicos Hospitalares S/A
  - São Paulo, São Paulo, Brasilien, 05403-000
    - Instituto do Coracao - HCFMUSP
  - Votuporanga, São Paulo, Brasilien, 15500-269
    - Integral Pesquisa e Ensino
Bulgarien
- - Dimitrovgrad, Bulgarien, 6400
    - Medical Centre Diamedical-2013
  - Dimitrovgrad, Bulgarien, 6400
    - MC Diamedical - 2013 OOD, Dimitrovgrad
  - Kyustendil, Bulgarien, 2500
    - 'Medical center Medi city 21' OOD
  - Kyustendil, Bulgarien, 2500
    - Medical center Medi City 21 OOD
  - Montana, Bulgarien, 3400
    - MC Hera EOOD - Montana
  - Pernik, Bulgarien, 2300
    - SHATC Sveti Georgi - Pernik OOD
  - Pleven, Bulgarien, 5800
    - Medical center Medconsult Pleven OOD
  - Pleven, Bulgarien, 5800
    - "Medical center Medconsult Pleven" OOD
  - Pleven, Bulgarien, 5804
    - MHAT Heart and brain
  - Pleven, Bulgarien, 5804
    - MHAT Heart and Brain EAD - Pleven, Cardiology
  - Plovdiv, Bulgarien, 4002
    - UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
  - Sliven, Bulgarien, 8800
    - 'MHAT Hadzhi Dimitar' OOD
  - Sliven, Bulgarien, 8800
    - MHAT Hadzhi Dimitar OOD
  - Sofia, Bulgarien, 1309
    - MHAT National Cardiology Hospital EAD
  - Sofia, Bulgarien, 1431
    - UMHAT "Sveti Ivan Rilski"
  - Sofia, Bulgarien, 1407
    - "Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic
  - Sofia, Bulgarien, 1750
    - "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology
  - Sofia, Bulgarien, 1750
    - "UMHAT "Sveta Anna" Sofia"
  - Sofia, Bulgarien, 1431
    - DCC Aleksandrovska EOOD
  - Sofia, Bulgarien, 1309
    - Mhat "Nch"
  - Sofia, Bulgarien, 1527
    - Medical center ISUL - Tsaritsa Yoanna EOOD
  - Sofia, Bulgarien, 1431
    - UMHAT Sveti Ivan Rilski EAD, Nephrology
  - Sofia, Bulgarien, 1415
    - Acibadem City Clinic UMHAT EOOD, Cardiology
  - Sofia, Bulgarien, 1510
    - MC Hera EOOD - Sofia
  - Sofia, Bulgarien, 1750
    - UMHAT Sveta Anna Sofia AD, Clinic of Cardiology
  - Sofia, Bulgarien, 1750
    - UMHAT Sveta Anna Sofia AD, Second Clinic of Internal Diseases
  - Stara Zagora, Bulgarien, 6001
    - Medical Center "Nov Rehabilitatsionen center" EOOD
  - Stara Zagora, Bulgarien, 6000
    - Prevencia - 2000 - MCOC OOD
  - Stara Zagora, Bulgarien, 6001
    - Medical Center Nov Rehabilitatsionen center EOOD
  - Varna, Bulgarien, 9010
    - UMHAT Sveta Marina EAD, Second Clinic of Cardiology
  - Yambol, Bulgarien, 8600
    - MC Berbatov EOOD, Cherni Drin
Canada
- - Québec, Canada, G1V 4G5
    - Institut universitaire de cardiologie
  - Québec, Canada, G1V4G2
    - CHU de Quebec-Universite Laval
  - Québec, Canada, G1G 5X1
    - Recherche Clinique Sigma inc
- Alberta
  - Calgary, Alberta, Canada, T2H 2G4
    - LMC Clin Res Inc. Calgary
  - Calgary, Alberta, Canada, T2V 4J2
    - C-Health Partners
  - Sherwood Park, Alberta, Canada, T8H 0N2
    - Synergy Wellness Clinic
- British Columbia
  - Vancouver, British Columbia, Canada, V5Y 3W2
    - BC Diabetes Canada
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 2Y9
    - Nova Scotia Hlth Halifax
- Ontario
  - Barrie, Ontario, Canada, L4N 7L3
    - LMC Diabetes & Endocrinology (Barrie)
  - Brampton, Ontario, Canada, L6S 0C6
    - LMC ClinRsrh Inc.Brampton
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - Concord, Ontario, Canada, L4K 4M2
    - LMC Clin Res Inc. Thornhill
  - Etobicoke, Ontario, Canada, M9R 4E1
    - Centricity Research Etobicoke Endocrinology
  - Hamilton, Ontario, Canada, L8L 5G4
    - Premier Clinical Trial Research Network (PCTRN)
  - Mississauga, Ontario, Canada, L4Y 1M3
    - One Heart Care
  - Nepean, Ontario, Canada, K2J 0V2
    - LMC Research Inc. Ottawa
  - Newmarket, Ontario, Canada, L3Y 2P6
    - Partnrs Adv Cardio Eval (PACE)
  - North York, Ontario, Canada, M6B 3H7
    - North York Diagn & Cardiac Ctr
  - Oakville, Ontario, Canada, L6M 1M1
    - LMC Clinical Research Inc. Oakville
  - Oakville, Ontario, Canada, L6K 3W7
    - Oakville Cardiovascular Research LP
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - Scarborough Village, Ontario, Canada, M1B 4Z8
    - Heart Health Institute Research, Inc.
  - Toronto, Ontario, Canada, M6G 1M2
    - Diabetes Heart Research Centre
  - Toronto, Ontario, Canada, M4G 3E8
    - LMC Endo Centres Ltd.(Bayview)
  - Waterloo, Ontario, Canada, N2T 0C1
    - Clinical Research Solutions Inc.
- Quebec
  - Brossard, Quebec, Canada, J4Z-2K9
    - Viacar Recherche Clinique Inc.
  - Laval, Quebec, Canada, H7T 2P5
    - Ctr de recherche Clinique de Laval
  - Longueuil, Quebec, Canada, J4H4B9
    - Viacar Recherche Clinique Inc.
  - Sherbrooke, Quebec, Canada, J1H 5N4
    - Centre de Recherche du CHUS
  - Terrebonne, Quebec, Canada, J6V 2H2
    - Centre de santé et de services
Danmark
- - Aarhus N, Danmark, 8200
    - Aarhus Universitetshospital, Hjertesygdomme
  - Gistrup, Danmark, 9260
    - Aalborg Universitetshospital Hjertemedicinsk Afdeling
  - Herning, Danmark, 7400
    - Regionshospitalet Gødstrup, Hjertesygdomme
  - Hvidovre, Danmark, 2650
    - Hvidovre Hospital Hjertemedicinsk
  - Kolding, Danmark, 6000
    - Kolding Sygehus Karkirurgi
  - Roskilde, Danmark, 4000
    - Sjællands Universitetshospital, Roskilde - Kardiologisk Afdeling
  - Svendborg, Danmark, 5700
    - Svendborg Sygehus - Kardiologisk
  - Viborg, Danmark, 8800
    - Viborg Sygehus
- Region Sjælland
  - Holbæk, Region Sjælland, Danmark, 4300
    - Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4
Det Forenede Kongerige
- - Barnet, Det Forenede Kongerige, EN5 3DJ
    - Barnet Hospital - Cardiology Department
  - Birmingham, Det Forenede Kongerige, B71 4HJ
    - Sandwell General Hospital
  - Bradford, Det Forenede Kongerige, BD9 6RJ
    - Bradford Royal Infirmary
  - Bradford-on-Avon, Det Forenede Kongerige, BA15 1DQ
    - The Health Centre
  - Bristol, Det Forenede Kongerige, BS10 5NB
    - Southmead Hospital
  - Cambridge, Det Forenede Kongerige, CB5 8PD
    - Addenbrooke's Hospital - Cambridge Dialysis Centre
  - Dorset, Det Forenede Kongerige, BH16 5PW
    - The Adam Practice
  - Durham, Det Forenede Kongerige, DL3 8SQ
    - Carmel Medical Practice
  - Exeter, Det Forenede Kongerige, EX2 5DW
    - Royal Devon and Exeter Hospital
  - High Wycombe, Det Forenede Kongerige, HP11 2TT
    - Wycombe General Hospital
  - Leicester, Det Forenede Kongerige, LE5 4PW
    - Leicester General Hospital
  - Leicester, Det Forenede Kongerige, LE3 9QP
    - Cardiology
  - Lincoln, Det Forenede Kongerige, LN2 5QY
    - Lincoln County Hospital
  - Liverpool, Det Forenede Kongerige, L9 7AL
    - Aintree University Hospital
  - Liverpool, Det Forenede Kongerige, L14 3PE
    - Liverpool Heart & Chest Hospital
  - Liverpool, Det Forenede Kongerige, L9 7AL
    - University Hospital Aintree
  - London, Det Forenede Kongerige, SE5 9RS
    - King's College Hospital
  - London, Det Forenede Kongerige, EC1M 6BQ
    - William Harvey Research Institute
  - London, Det Forenede Kongerige, EC1M 6BQ
    - William Harvey Clinical Research Centre
  - Newcastle upon Tyne, Det Forenede Kongerige, NE7 7DN
    - Freeman Hospital, Newcastle
  - Oxford, Det Forenede Kongerige, OX3 9DU
    - John Radcliffe Hospital
  - Preston, Det Forenede Kongerige, PR2 9RB
    - Panthera Biopartners Preston
  - Royal Leamington Spa, Det Forenede Kongerige, CV32 4RA
    - Sherbourne Medical Centre
  - Stevenage, Det Forenede Kongerige, SG1 4AB
    - Lister Hospital
  - Stockton-on-Tees, Det Forenede Kongerige, TS19 8PE
    - University of North Tees Hospital
  - Taunton, Det Forenede Kongerige, TA1 5DA
    - Musgrove Park Hospital
  - Torquay, Det Forenede Kongerige, TQ2 7AA
    - Torbay Hospital - Cardiology
  - Wellingborough, Det Forenede Kongerige, NN8 4RW
    - Albany House Medical Centre
- Cheshire
  - Sandbach, Cheshire, Det Forenede Kongerige, CW11 1EQ
    - Ashfields Primary Care Centre
- Dorset
  - Bournemouth, Dorset, Det Forenede Kongerige, BH7 7DW
    - Royal Bournemouth Hospital - Cardiology
  - Dorchester, Dorset, Det Forenede Kongerige, DT1 2JY
    - Dorset County Hospital
- Lancashire
  - Blackpool, Lancashire, Det Forenede Kongerige, FY3 8NR
    - Blackpool Victoria Hospital
- North Yorkshire
  - Pickering, North Yorkshire, Det Forenede Kongerige, YO18 8BL
    - Pickering Medical Practice
- Northamptonshire
  - Corby, Northamptonshire, Det Forenede Kongerige, NN17 2UR
    - Lakeside Healthcare Research & Innovation Unit
- Surrey
  - Addlestone, Surrey, Det Forenede Kongerige, KT15 2BH
    - The Crouch Oak Family Practice
- West Sussex
  - Chichester, West Sussex, Det Forenede Kongerige, PO19 6SE
    - St. Richard's Hospital_Cardiology
Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - Uni of Alabama at Birmingham
  - Montgomery, Alabama, Forenede Stater, 36106
    - Chambliss Clinical Trials LLC
- Arizona
  - Glendale, Arizona, Forenede Stater, 85308
    - Lenzmeier Fam Med CCT Research
  - Mesa, Arizona, Forenede Stater, 85206
    - Aventiv Research Inc.
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72205
    - Univ of Arkansas Med Sciences
  - Searcy, Arkansas, Forenede Stater, 72143
    - Unity Health-Searcy Medical Center
- California
  - Beverly Hills, California, Forenede Stater, 90211
    - National Heart Institute Cal
  - Chula Vista, California, Forenede Stater, 91910
    - California Inst Of Renal Res
  - Chula Vista, California, Forenede Stater, 91910
    - California Institute of Renal Research #10
  - Covina, California, Forenede Stater, 91723
    - Valley Clinical Trials
  - Huntington Park, California, Forenede Stater, 90255
    - Valiance Clinical Research
  - La Jolla, California, Forenede Stater, 92037
    - Scripps Wht Diab Inst La Jolla
  - La Mesa, California, Forenede Stater, 91942
    - Balboa Nephro Med Gr Inc LaMes
  - Lancaster, California, Forenede Stater, 93534
    - First Valley Medical Group
  - Loma Linda, California, Forenede Stater, 92357
    - VA Loma Linda Hlthcr Sys
  - Los Alamitos, California, Forenede Stater, 90720
    - Pacific Clinical Studies
  - Los Angeles, California, Forenede Stater, 90010
    - Angel City Research, Inc.
  - Lynwood, California, Forenede Stater, 90262
    - North America Research Institute
  - Newport Beach, California, Forenede Stater, 92663
    - Hoag Medical Group
  - Northridge, California, Forenede Stater, 91325
    - Valley Clinical Trials, Inc.
  - Palm Springs, California, Forenede Stater, 92262
    - Desert Oasis Hlthcr Med Group
  - Riverside, California, Forenede Stater, 92503
    - Riverside Nephrology Physicians
  - San Dimas, California, Forenede Stater, 91773
    - N America Res Inst - San Dimas
  - Torrance, California, Forenede Stater, 90502
    - Lundquist Inst-Biomed Innovtn
- Colorado
  - Denver, Colorado, Forenede Stater, 80204
    - Denver Health Outpatient Medical Center
- Connecticut
  - Bridgeport, Connecticut, Forenede Stater, 06610
    - Bridgeport Hospital
  - West Haven, Connecticut, Forenede Stater, 06516
    - VA-Connecticut (VACHS)
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20037
    - George Washington Uni Med
- Florida
  - Boca Raton, Florida, Forenede Stater, 33434
    - Excel Med Ctr Clinical Trials
  - Clearwater, Florida, Forenede Stater, 33756
    - Innovative Research of W FL
  - Delray Beach, Florida, Forenede Stater, 33445
    - Florida Premier Cardiology
  - Fleming Island, Florida, Forenede Stater, 32003
    - Northeast Research Institute
  - Fort Lauderdale, Florida, Forenede Stater, 33312
    - Integrative Research Assoc Inc
  - Hollywood, Florida, Forenede Stater, 33024
    - Encore Medical Research LLC
  - Hollywood, Florida, Forenede Stater, 33024
    - Elixia Pines
  - Jacksonville, Florida, Forenede Stater, 32216
    - Est Cst Inst for Rsrch,Jksnvil
  - Jacksonville, Florida, Forenede Stater, 32258
    - Baptist Heart Specialists
  - Jacksonville, Florida, Forenede Stater, 32204
    - Northeast Research Institute
  - Lakeland, Florida, Forenede Stater, 33805
    - Clinical Research of Cent FL
  - Miami, Florida, Forenede Stater, 33126
    - Pharmax Research Clinic
  - Miami, Florida, Forenede Stater, 33155
    - Allied Biomedical Research
  - Miami, Florida, Forenede Stater, 33130
    - Life Spring Research Foundation LLC
  - Miami Lakes, Florida, Forenede Stater, 33014
    - San Marcus Res Clin Miami Lakes
  - Miramar, Florida, Forenede Stater, 33027
    - Office of Kenneth Blaze DO
  - New Port Richey, Florida, Forenede Stater, 34652
    - Suncoast Clin Res Port Richey
  - Palm Harbor, Florida, Forenede Stater, 34684
    - Suncoast Clinical Research, Inc.
  - Pembroke Pines, Florida, Forenede Stater, 33024
    - A&R Research Group, LLC
  - Port Charlotte, Florida, Forenede Stater, 33952
    - Hanson Clinical Research Center
  - Port Charlotte, Florida, Forenede Stater, 33952
    - Peace River Cardiovascular Center
  - Saint Augustine, Florida, Forenede Stater, 32080
    - Northeast Research Institute
  - Saint Augustine, Florida, Forenede Stater, 32086
    - St Johns Center for Clin. Res
  - Saint Augustine, Florida, Forenede Stater, 32086
    - East Coast Institute for Research LLC_St. Augustine
- Georgia
  - Albany, Georgia, Forenede Stater, 31707
    - Javara/Privia Med Grp GA,LLC
  - Augusta, Georgia, Forenede Stater, 30904
    - Southeastern Clinical Research Institute, LLC
  - Augusta, Georgia, Forenede Stater, 30904
    - Southeastern Clinical R.I.
  - Conyers, Georgia, Forenede Stater, 30094
    - Hope Clin Res & Wellness
  - Fayetteville, Georgia, Forenede Stater, 30214
    - Javara Inc._Albany
  - Johns Creek, Georgia, Forenede Stater, 30024
    - NSC Research, Inc
  - Roswell, Georgia, Forenede Stater, 30076
    - Endo Res Solutions Inc
  - Savannah, Georgia, Forenede Stater, 31406
    - Javara Inc._Winston Salem
- Idaho
  - Nampa, Idaho, Forenede Stater, 83686-6011
    - Saltzer Medical Group Research
- Illinois
  - Arlington Heights, Illinois, Forenede Stater, 60005
    - Endeavor Health Clinical Operations-NCH
  - Chicago, Illinois, Forenede Stater, 60643
    - Research by Design LLC
  - Gurnee, Illinois, Forenede Stater, 60031
    - Clinical Invest Special_Gurnee
  - Hazel Crest, Illinois, Forenede Stater, 60429
    - Chicago Medical Research LLC
  - Skokie, Illinois, Forenede Stater, 60077
    - Endeavor Health
  - Springfield, Illinois, Forenede Stater, 62711
    - Central Illinois Diabetes and Clinical Research
  - Wauconda, Illinois, Forenede Stater, 60084
    - Clin Invest Spec, Inc
- Indiana
  - Evansville, Indiana, Forenede Stater, 47714
    - MediSphere Medical RC
  - Valparaiso, Indiana, Forenede Stater, 46383
    - Velocity Clin. Res Valparaiso
- Kansas
  - Overland Park, Kansas, Forenede Stater, 66211
    - Midwest Heart & Vasc Spec
  - Topeka, Kansas, Forenede Stater, 66606
    - Cotton O'Neil Diab & Endo Ctr
- Kentucky
  - Lexington, Kentucky, Forenede Stater, 40503
    - The Research Group of Lexington LLC
  - Lexington, Kentucky, Forenede Stater, 40502
    - Lexington VA Health Care System
  - Louisville, Kentucky, Forenede Stater, 40205
    - Norton Heart Specialists-Springs
- Louisiana
  - Bossier City, Louisiana, Forenede Stater, 71111
    - Grace Research, LLC
  - Monroe, Louisiana, Forenede Stater, 71201
    - Ima Clinical Research
  - Monroe, Louisiana, Forenede Stater, 71201
    - Clinical Trials of Ame, LLC
  - Shreveport, Louisiana, Forenede Stater, 71105
    - Grace Research, LLC_Shreveport
  - Slidell, Louisiana, Forenede Stater, 70458
    - Louisiana Heart Center_Slidell
- Maryland
  - Annapolis, Maryland, Forenede Stater, 21401
    - Anne Arundel Medical Center
  - Bethesda, Maryland, Forenede Stater, 20814
    - Suburban Hospital
  - Clinton, Maryland, Forenede Stater, 20735
    - John P Hakim MD and Associates
- Massachusetts
  - Boston, Massachusetts, Forenede Stater, 02115-5804
    - Brigham & Women's Hospital
  - Haverhill, Massachusetts, Forenede Stater, 01830
    - Pentucket Medical Associates
- Michigan
  - Detroit, Michigan, Forenede Stater, 48202
    - Henry Ford Hospital_Detroit
  - Flint, Michigan, Forenede Stater, 48532
    - Elite Research Center
  - Grand Rapids, Michigan, Forenede Stater, 49546
    - Healthy Heart Cardiology
  - Petoskey, Michigan, Forenede Stater, 49770
    - McLaren Northern MI Hosp
- Minnesota
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - AHS dba Abbot NW Hosp Diab Cen
  - Minneapolis, Minnesota, Forenede Stater, 55455
    - University of Minnesota_Minneapolis_1
- Missouri
  - Kansas City, Missouri, Forenede Stater, 64111
    - Clinical Research Consultants, LLC
  - St Louis, Missouri, Forenede Stater, 63136
    - St Louis Heart & Vascular, P.C.
  - St Louis, Missouri, Forenede Stater, 63128
    - Gateway CV Research Cntr Inc.
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68526
    - Nebraska Heart Institute_Lincoln
  - Omaha, Nebraska, Forenede Stater, 68105
    - VA NEB - Western IA Health Stm
  - Omaha, Nebraska, Forenede Stater, 68198-3020
    - Univ of Nebraska Medical CTR
  - Omaha, Nebraska, Forenede Stater, 68114
    - Methodist Phys Clin Heart Cons
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University of Nevada School of Medicine
  - Las Vegas, Nevada, Forenede Stater, 89128
    - Palm Research Center Inc-Vegas
- New Jersey
  - Bridgewater, New Jersey, Forenede Stater, 08807-3064
    - Advanced Heart Care LLC
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87106
    - Uni of New Mexico-Clinical
- New York
  - Mineola, New York, Forenede Stater, 11501
    - NYU Nephrology Associates
  - New York, New York, Forenede Stater, 10016
    - NYU Grossman School of Med
  - New York, New York, Forenede Stater, 10019
    - Mount Sinai Hosp at NYC
  - Northport, New York, Forenede Stater, 11768
    - Northport VA Med Ctr Northport
  - Ridgewood, New York, Forenede Stater, 11385
    - Mattoo & Bhat M.A.
  - Saratoga Springs, New York, Forenede Stater, 12866
    - Saratoga Clinical Research
  - The Bronx, New York, Forenede Stater, 10461
    - DaVita Clinical Research - New York
  - West Seneca, New York, Forenede Stater, 14224
    - Southgate Medical Group, LLP
  - Westfield, New York, Forenede Stater, 14787
    - Great Lakes Medical Research
- North Carolina
  - Asheville, North Carolina, Forenede Stater, 28801
    - Mountain Kidney & Hypertension Associates
  - Burlington, North Carolina, Forenede Stater, 27215
    - Kernodle Clin Dpt-Pvt Diagnost
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC- Chapel Hill
  - Charlotte, North Carolina, Forenede Stater, 28208
    - Metrolina Nephrology Associates, PA
  - Charlotte, North Carolina, Forenede Stater, 28210
    - Javara Inc._Charlotte
  - Greensboro, North Carolina, Forenede Stater, 27408
    - PharmQuest Life Sciences LLC
  - Greenville, North Carolina, Forenede Stater, 27834
    - Physicians East Endocrinology
  - Morehead City, North Carolina, Forenede Stater, 28557
    - Carteret Medical Group
- North Dakota
  - Fargo, North Dakota, Forenede Stater, 58104
    - Lillestol Research LLC
- Ohio
  - Cincinnati, Ohio, Forenede Stater, 45267
    - Univ of Cincinnati Med Cent
  - Cleveland, Ohio, Forenede Stater, 44106
    - VA Northeast Ohio Healthcare System (VANEOHS)
  - Maumee, Ohio, Forenede Stater, 43537
    - Advanced Med Res Maumee
- Pennsylvania
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Northeast Clinical Research Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19144
    - Parkside Family Medicine
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Aria Endocrine Metabolic Assoc
- Rhode Island
  - Lincoln, Rhode Island, Forenede Stater, 02865
    - Ocean St Clin Res Partnrs, LLC
- South Carolina
  - Fort Mill, South Carolina, Forenede Stater, 29707
    - Piedmont Research Partners, LLC
  - Greenville, South Carolina, Forenede Stater, 29615
    - Palmetto Clinical Research
  - Myrtle Beach, South Carolina, Forenede Stater, 29588
    - Family Medicine of SayeBrook LLC
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Research
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37411
    - Univ Diab & Endo Consultants
  - Greeneville, Tennessee, Forenede Stater, 37745
    - Balad Hlth Sys-Welmont CardCVA
  - Knoxville, Tennessee, Forenede Stater, 37934
    - Tennova HC Turkey Creek MC
  - Memphis, Tennessee, Forenede Stater, 38119
    - Clinical Neuroscience Solutions
  - Powell, Tennessee, Forenede Stater, 37849
    - CV Research of Knoxville
- Texas
  - Arlington, Texas, Forenede Stater, 76012-4637
    - Arlington Family Res. Ctr Inc
  - Arlington, Texas, Forenede Stater, 76002
    - Liberty Research Center
  - Bellaire, Texas, Forenede Stater, 77401
    - Novel Research LLC
  - Corpus Christi, Texas, Forenede Stater, 78414
    - Osvaldo A. Brusco MD
  - Cypress, Texas, Forenede Stater, 77429
    - Research Trials Worldwide LLC
  - Dallas, Texas, Forenede Stater, 75204
    - Renal Disease Research Institute
  - Dallas, Texas, Forenede Stater, 75208
    - Thyroid Endocrinology & Diabetes PA
  - Dallas, Texas, Forenede Stater, 75230
    - Liberty Research Center_Dallas
  - Edinburg, Texas, Forenede Stater, 78539
    - DHR Health Inst for Res & Dev
  - El Paso, Texas, Forenede Stater, 79935
    - Academy of Diabetes, T&E
  - Forney, Texas, Forenede Stater, 75126
    - Care United Research, LLC
  - Fort Worth, Texas, Forenede Stater, 76132
    - Diabetes and Thyroid Ctr of FW
  - Fort Worth, Texas, Forenede Stater, 76133
    - Javara /TX.Hlth LLC dba Prvia
  - Houston, Texas, Forenede Stater, 77084
    - Biopharma Informatic, LLC
  - Houston, Texas, Forenede Stater, 77024
    - PrimeCare Medical Group
  - Houston, Texas, Forenede Stater, 77054
    - Prolato Clinical Research Center
  - Houston, Texas, Forenede Stater, 77079
    - PlanIt Research, PLLC
  - Houston, Texas, Forenede Stater, 77043
    - Biopharma Informatic_Houston
  - Houston, Texas, Forenede Stater, 77054
    - Prolato Clinical Research Cntr
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College Of Medicine_Houston
  - Houston, Texas, Forenede Stater, 77070
    - Card Specialists of Willowbrook
  - Houston, Texas, Forenede Stater, 77090
    - Biopharma Informatic_Houston_0
  - Houston, Texas, Forenede Stater, 77030
    - Baylor College Of Medicine_Houston Travis Street
  - Longview, Texas, Forenede Stater, 75605
    - DCOL Ctr for Clin Res
  - Lufkin, Texas, Forenede Stater, 75904
    - Texas Inst, Kdny & Endo Disor
  - McAllen, Texas, Forenede Stater, 78503
    - RGV Endocrine Center
  - Rockwall, Texas, Forenede Stater, 75032
    - Carlos Arauz-Pacheco Md, Pa
  - San Antonio, Texas, Forenede Stater, 78229
    - University Hospital
  - San Antonio, Texas, Forenede Stater, 78215
    - Sun Research Institute
  - San Antonio, Texas, Forenede Stater, 78212
    - Clinical Advancement Center
  - San Antonio, Texas, Forenede Stater, 78230
    - VIP Trials
  - San Antonio, Texas, Forenede Stater, 78224
    - Briggs Clinical Research, LLC
  - San Antonio, Texas, Forenede Stater, 78233
    - NE Clin Res of San Antonio
  - San Marcos, Texas, Forenede Stater, 78666
    - Javara Privia Grp Gulf Cst LLC
  - Sugar Land, Texas, Forenede Stater, 77478
    - Simcare Medical Research, LLC
  - Waco, Texas, Forenede Stater, 76708
    - Hillcrest Family Health Center
- Utah
  - Salt Lake City, Utah, Forenede Stater, 84108
    - University of Utah School of Medicine
- Virginia
  - Forest, Virginia, Forenede Stater, 24551
    - Javara Inc/Privia Md GpLLC Fst
  - Norfolk, Virginia, Forenede Stater, 23504
    - York Clinical Research LLC
  - Richmond, Virginia, Forenede Stater, 23298
    - Virginia Commonwealth University Health System
  - Salem, Virginia, Forenede Stater, 24153-6404
    - VA Medical Center_Salem
  - Winchester, Virginia, Forenede Stater, 22601-3834
    - Selma Medical Associates
- Washington
  - Spokane, Washington, Forenede Stater, 99204
    - Providence Medical Research Center
- Wisconsin
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Research Institute
  - Weston, Wisconsin, Forenede Stater, 54476
    - Marshfield Clinic
Grækenland
- - Alexandroupoli, Grækenland, 68100
    - Alexandroupoli University General Hospital
  - Athens, Grækenland, 11527
    - "Laiko" General Hospital of Athens
  - Athens, Grækenland, 11528
    - Alexandra General Hospital, Therapeutic Clinic
  - Athens, Grækenland, 11527
    - Hippokration Hospital
  - Athens, Grækenland, GR-17562
    - Iatriko Athinon 'Palaiou Falirou'
  - Athens, Grækenland, GR-14233
    - Konstantopouleio G.H. of Athens, "Agia Olga"
  - Athens, Grækenland, GR-15123
    - "Hygeia" General Hospital of Athens
  - Athens, Grækenland, 15125
    - Iatriko Athinon (Athens Medical Canter)
  - Athens, Grækenland, 17562
    - Iatriko Athinon 'Palaiou Falirou'
  - Athens, Grækenland, 14233
    - Konstantopouleio G.H. of Athens, "Agia Olga"
  - Athens, Grækenland, 15123
    - "Hygeia" General Hospital of Athens
  - Athens, Grækenland, 11527
    - Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
  - Chios, Grækenland, GR82100
    - General Hospital of Chios "Skilitsio"
  - Chios, Grækenland, 82100
    - General Hospital of Chios "Skilitsio" - Cardiology Clinic
  - Heraklion, Grækenland, 71500
    - University General Hospital of Heraklion
  - Heraklion, Grækenland, 71500
    - Periphery University Hospital of Heraklion
  - Ioannina, Grækenland, 45500
    - University General Hospital of Ioannina,Internal Medicine
  - Kifissia, Grækenland, GR-14561
    - KAT General Hospital of Attica
  - Kifissia, Grækenland, 14561
    - Kat Attica General Hospital - Cardiology Department
  - Lamia, Grækenland, 35100
    - General Hospital of Lamia
  - Larissa, Grækenland, GR-41110
    - Univ Gen Hospital Larisa, Cardiology Medicine Clinic
  - Larissa, Grækenland, 41110
    - Univ Gen Hospital Larisa, Cardiology Medicine Clinic
  - Pylea, Thessaloniki, Grækenland, 57001
    - Iatriko Athinon (Athens Medical Canter)
  - Rio, Patra, Grækenland, 26504
    - General University Hospital of Patras,Nephrology clinic
  - Thessaloniki, Grækenland, 54636
    - "AHEPA" University General Hospital of Thessaloniki
  - Thessaloniki, Grækenland, 54642
    - General Hospital of Thessaloniki "Ippokrateio"
  - Thessaloniki, Grækenland, GR-57001
    - "Thermi" Private Hosital
  - Thessaloniki, Grækenland, 54636
    - "AHEPA" University Hospital of Thessaloniki
  - Thessaloniki, Grækenland, 57001
    - "Thermi" Private Hosital
  - Thessaloniki, Grækenland, 54642
    - General Hospital of Thessaloniki 'Ippokrateio' Dialysis Unit
  - Thessaloniki, Grækenland, 57010
    - Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt
  - Thessaloniki, Grækenland, 57001
    - Iatriko Athinon (Athens Medical Canter)
  - Thessaloniki, Grækenland, 55134
    - General Hospital of Thessaloniki 'Agios Pavlos' - Nephrology Clinic
- Attica
  - Athens, Attica, Grækenland, 12462
    - University Hospital of Athens ATTIKON
  - Haidari-Athens, Attica, Grækenland, GR-12462
    - University Hospital of Athens ATTIKON
Holland
- - Alkmaar, Holland, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almelo, Holland, 7609 PP
    - Ziekenhuis Groep Twente Almelo
  - Almelo, Holland, 7609 PP
    - ZGT Almelo - Cardiologie
  - Amsterdam, Holland, 1105 AZ
    - Academisch Medisch Centrum
  - Amsterdam, Holland, 1105 AZ
    - AmsterdamUMC AMC
  - Apeldoorn, Holland, 7334 DZ
    - Gelre Ziekenhuizen Apeldoorn
  - Apeldoorn, Holland, 7334 DZ
    - Gelre Zkh Apeldoorn Cardiologie
  - Breda, Holland, 4818 CK
    - Amphia ziekenhuis
  - Harderwijk, Holland, 3844 DG
    - St Jansdal
  - Hilversum, Holland, 1213 XZ
    - Tergooi, locatie Hilversum
  - Hilversum, Holland, 1212 VG
    - Tergooi, Hilversum
  - Leiden, Holland, 2333 ZA
    - Leids Universitair Medisch Centrum
  - Roosendaal, Holland, 4708 AE
    - Bravis ziekenhuis
  - Roosendaal, Holland, 4708 AE
    - Bravis Zkh Roosendaal
  - Rotterdam, Holland, 3083 AN
    - Ikazia Ziekenhuis
  - Sneek, Holland, 8601 ZR
    - D & A Research B.V.
  - Zaandam, Holland, 1502 DV
    - Zaans Medisch Centrum
Indien
- - Chandigarh, Indien, 160012
    - Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
  - Jaipur, Indien, 302017
    - Eternal Heart Care Centre
  - New Delhi, Indien, 110060
    - Sir Ganga Ram Hospital
  - New Delhi, Indien, 110002
    - G B Pant Institute of Postgraduate Medical Education and Res
  - New Delhi, Indien, 110017
    - Max Super Speciality Hospital_New Delhi
  - New Delhi, Indien, 110002
    - Lok Nayak Hospital
  - New Delhi, Indien, 110017
    - Max Super Speciality Hospital, Saket
  - New Delhi, Indien, 110025
    - Fortis Escort Health Institute
  - Palakkad, Indien, 678013
    - Lakshmi Hospital
- Andhra Pradesh
  - Guntur, Andhra Pradesh, Indien, 522001
    - Vedanta Hospitals
  - Guntur, Andhra Pradesh, Indien, 522001
    - Lalitha PVS Institute of Medical Sciences
  - Hyderabad, Andhra Pradesh, Indien, 500082
    - Nizam's Institute of Medical Sciences
  - Vijayawada, Andhra Pradesh, Indien, 520002
    - Sunrise Hospital
- Gujarat
  - Ahmedabad, Gujarat, Indien, 380059
    - Apollo CHSF Heart Institute
  - Surat, Gujarat, Indien, 395009
    - BAPS Pramukh Swami Hospital
  - Surat, Gujarat, Indien, 395001
    - Shri B. D. Mehta Mahavir Heart Institute
  - Surat, Gujarat, Indien, 395001
    - Unicare heart institute and research centre
- Karnataka
  - Bangalore, Karnataka, Indien, 560092
    - Lifecare Hospital and Research Centre
  - Bangalore, Karnataka, Indien, 560017
    - Manipal Hospital, Old Airport Road, Bengaluru
  - Bengaluru, Karnataka, Indien, 560069
    - Sri Jayadeva Institute of Cardiovascular Sciences & Research
  - Mangalore, Karnataka, Indien, 575002
    - Omega Hospital (P) Limited
  - Manipal, Karnataka, Indien, 576104
    - Kasturba Medical College and Hospital
  - Manipal, Karnataka, Indien, 576104
    - Kasturba Medical College and Hospital, Manipal
- Karnatka
  - Belagavi, Karnatka, Indien, 590010
    - KLES & Prabhakar Kore Hospital and Research Centre
- Kerala
  - Kochi, Kerala, Indien, 682018
    - Lisie Hospital
  - Kozhikode, Kerala, Indien, 673008
    - Calicut Medical College
  - Trivandrum, Kerala, Indien, 695011
    - Government Medical College Trivandrum
- Maharashtra
  - Aurangabad, Maharashtra, Indien, 431010
    - Kamalnayan Bajaj Hospital
  - Aurangabad, Maharashtra, Indien, 431005
    - Kamalnayan Bajaj Hospital
  - Mumbai, Maharashtra, Indien, 400012
    - Seth GS medical college and KEM Hospital
  - Nagpur, Maharashtra, Indien, 440012
    - Shri Krishna Hrudayalaya & Critical Care Centre
  - Nagpur, Maharashtra, Indien, 440010
    - Arneja Heart & Multispeciality Hospital
  - Nagpur, Maharashtra, Indien, 440009
    - Government Medical College and Super Speciality Hospital, Nagpur
  - Nashik, Maharashtra, Indien, 422005
    - Vijan Hospital & Research Centre
  - Nashik, Maharashtra, Indien, 422005
    - Chopda Medicare and Research Centre Pvt. Ltd.
  - Pune, Maharashtra, Indien, 411001
    - Grant Medical Foundation
  - Pune, Maharashtra, Indien, 411001
    - B J Goverment Medical College and Sassoon General Hospital
- National Capital Territory of Delhi
  - New Delhi, National Capital Territory of Delhi, Indien, 110002
    - G B Pant Institute of Postgraduate Medical Education and Research
  - New Delhi, National Capital Territory of Delhi, Indien, 110062
    - Batra Hospital and Medical Research Center
  - New Delhi, National Capital Territory of Delhi, Indien, 110025
    - Fortis Escorts Heart Institute, New Delhi
- New Delhi
  - New Dehli, New Delhi, Indien, 110029
    - VMMC & Safdarjung Hospital
- Punjab
  - Ludhiana, Punjab, Indien, 141001
    - Dayanand Medical College & Hospital
- Tamil Nadu
  - Chennai, Tamil Nadu, Indien, 600006
    - Apollo Hospitals Education & Research Foundation
- Telangana
  - Hyderabad, Telangana, Indien, 500012
    - Osmania General Hospital
  - Hyderabad, Telangana, Indien, 500020
    - Guru Nanak CARE Hospitals
  - Hyderabad, Telangana, Indien, 500012
    - Osmania General Hospital_Hyderabad
  - Hyderabad, Telangana, Indien, 500033
    - Apollo Hospital Jubilee Hills, Hyderabad
  - Hyderbad, Telangana, Indien, 500 012
    - Osmania General Hospital
- Uttar Pradesh
  - Lucknow, Uttar Pradesh, Indien, 226030
    - Medanta Lucknow Hospital
  - Lucknow, Uttar Pradesh, Indien, 226003
    - Gandhi Memorial Hospital- King George's Medical University
Israel
- - Holon, Israel, 58100
    - Wolfson MC - Diabetes Clinic
  - Jerusalem, Israel, 91120
    - Hadassah Ein Karam MC - Cardio Department
  - Nahariya, Israel, 22100
    - Western Galilee MC - Cardiology Department
  - Petah Tikva, Israel, 49100
    - Rabin MC Beilinson - Heart Failure Unit
  - Rehovot, Israel, 7661041
    - Kaplan MC - Nephrology unit
  - Tel Aviv, Israel, 6423906
    - Sourasky MC - Cardio Vascular Research Center
  - Tel Litwinsky, Israel, 5265601
    - Sheba MC - Cardiology Clinical Research Unit
Italien
- - Arzignano (VI), Italien, 36071
    - West Vicenza General Hospital
  - Bologna, Italien, 40138
    - Policlinico S. Orsola - Malpighi
  - Catania, Italien, 95126
    - AO Cannizzaro
  - Chieti Scalo, Italien, 66100
    - Università degli studi G. D'Annunzio Chieti Pescara - CAST
  - Florence, Italien, 50134
    - AOU Careggi Firenze
  - Genova, Italien, 16132
    - IRCCS Ospedale Policlinico San Martino
  - Genova, Italien, 16132
    - IRCCS Azienda Ospedaliero Universitaria San Martino - IST
  - Milan, Italien, 20138
    - Centro Cardiologico Monzino
  - Milan, Italien, 20132
    - Ospedale San Raffaele S.r.l. - Unità Clinica Riabilitazione Specialistica Cardiologica
  - Montichiari, Italien, 25018
    - ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari
  - Naples, Italien, 80131
    - Azienda Ospedaliera Universitaria Federico II Di Napoli
  - Palermo, Italien, 90127
    - AOUP Giaccone Palermo
  - Palermo, Italien, 90127
    - ARNAS Ospedali Civico Di Cristina Benfratelli - Presidio Ospedaliero "Civio e Benfratelli"
  - Pavia, Italien, 27100
    - Fondazione IRCCS Policlinico San Matteo
  - Pisa, Italien, 56124
    - AOU Pisana Cisanello
  - Roma, Italien, 00133
    - Policlinico Tor Vergata
  - Roma, Italien, 00168
    - Policlinico A. Gemelli IRCCS
  - Rome, Italien, 00189
    - AOU S. Andrea
  - Trieste, Italien, 34128
    - Azienda Sanitaria Univ Giuliano Isontina - SC Cardiologia
  - Verona, Italien, 37126
    - AOUI Verona
- Cz
  - Catanzaro, Cz, Italien, 88100
    - Azienda Ospedaliero-Universitaria Renato Dulbecco
- Fe
  - Cona (Ferrara), Fe, Italien, 44124
    - A.O.U. Ferrara, Sant'Anna
- Lombardy
  - Bergamo, Lombardy, Italien, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
- RM
  - Roma, RM, Italien, 00161
    - Policlinico Umberto I Seconda Clinica Medica
Japan
- - Bunkyo-ku, Tokyo, Japan, 113-8655
    - The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
  - Bunkyo-ku, Tokyo, Japan, 113-8603
    - NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine
  - Chiba-shi, Chiba, Japan, 260-0804
    - Akaicho Clinic
  - Chikushino-shi, Fukuoka, Japan, 818-8516
    - Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine
  - Chuo-city, Yamanashi, Japan, 409-3898
    - University of Yamanashi Hospital_Cardiology
  - Fukuoka, Japan, 810-8563
    - National Hospital Organization Kyushu Medical Center_Nephrology
  - Fukuoka-shi, Fukuoka, Japan, 814-0133
    - Fukuoka University Hospital_Cardiology
  - Fukuoka-shi, Fukuoka, Japan, 810-0001
    - Saiseikai Fukuoka General Hospital
  - Hamada-shi, Shimane, Japan, 697-8511
    - National Hospital Organization Hamada Medical Center_Cardiology
  - Hamamatsu-shi, Shizuoka, Japan, 430-0929
    - JA Shizuoka Kohseiren Enshu Hospital_ cardiology
  - Ibaraki, Japan, 311-0113
    - Naka Kinen Clinic
  - Ibaraki, Japan, 311-3193
    - National Hospital Organization Mito Medical Center_Cardiovascular medicine
  - Ibaraki, Japan, 311-0113
    - Naka Kinen Clinic_Internal medicine
  - Ibaraki, Japan, 331-0133
    - Nishiyamado Keiwa Hospital_Internal Medicine
  - Ibaraki, Japan, 331-0133
    - Nishiyamado Keiwa Hospital
  - Kishiwada, Osaka, Japan, 596-0042
    - Kishiwada Tokushukai Hospital_Cardiology
  - Kita-azumi-gun, Nagano, Japan, 399-8695
    - North Alps Medical Center Azumi Hospital_Cardiology
  - Kitakyushu-shi, Fukuoka, Japan, 805-8508
    - Steel Memorial Yawata Hospital_Cardiology
  - Kitakyushu-shi,Fukuoka, Japan, 802-8555
    - Kokura Memorial Hospital_Cardiology
  - Koga-shi, Fukuoka, Japan, 811-3195
    - National Hospital Organization Fukuokahigashi Medical Center
  - Koga-shi, Fukuoka, Japan, 811-3195
    - National Hospital Organization Fukuokahigashi Medical Center_Nephrology
  - Kumamoto-shi, Kumamoto, Japan, 860-8556
    - Kumamoto University Hospital, Cardiovascular Medicine
  - Kure-shi, Hiroshima, Japan, 737-0023
    - NHO Kure Medical Center and Chugoku Cancer Center_Cardiology
  - Kusegun, Kyoto, Japan, 613-0034
    - Kyoto Okamoto Memorial Hospital
  - Kusegun, Kyoto, Japan, 613-0034
    - Kyoto Okamoto Memorial Hospital_Cardiology
  - Kyoto-shi, Kyoto, Japan, 612-8555
    - National Hospital Organization Kyoto Medical Center_Cardiology
  - Kyoto-shi, Kyoto, Japan, 607-8062
    - Rakuwakai Otowa Hospital
  - Kyoto-shi, Kyoto, Japan, 607-8062
    - Rakuwakai Otowa Hospital_Cardiology
  - Kyoto-shi,Kyoto, Japan, 601-1495
    - Ijinkai Takeda General Hospital, Cardiovascular Medicine
  - Maebashi-shi, Gunma, Japan, 371-0811
    - Maebashi Red Cross Hospital
  - Maebashi-shi, Gunma, Japan, 371-0811
    - Maebashi Red Cross Hospital_Cardiology
  - Matsubara-shi, Osaka, Japan, 580-0032
    - Matsubara Tokushukai Hospital_Neurosurgery
  - Matsudo-shi, Japan, 270-2251
    - Chiba-Nishi General Hospital, Cardiology
  - Matsumoto-shi, Nagano, Japan, 390-8621
    - Shinshu University Hospital_Matsumoto-shi, Nagano
  - Matsumoto-shi, Nagano, Japan, 390-8621
    - Shinshu University Hospital__Department of Cardiology
  - Meguro-ku, Tokyo, Japan, 153-0051
    - Mishuku Hospital_Cardiology
  - Minato-ku, Tokyo, Japan, 108-0073
    - Tokyo Saiseikai Central Hospital
  - Miura-gun, Kanagawa, Japan, 240-0116
    - Hayama Heart Center
  - Miura-gun, Kanagawa, Japan, 240-0116
    - Hayama Heart Center_Cardiology
  - Miyakonojo-shi, Miyazaki, Japan, 885-0002
    - Miyakonojo Medical Association Hospital
  - Miyakonojo-shi, Miyazaki, Japan, 885-0002
    - Miyakonojo Medical Association Hospital_Cardiology
  - Morioka-shi, Iwate, Japan, 020-0066
    - Iwate Prefectural Central Hospital
  - Morioka-shi, Iwate, Japan, 020-0066
    - Iwate Prefectural Central Hospital_Cardiology
  - Nagoya-shi, Aichi, Japan, 457-0818
    - Social Medical Corporation Kojunkai Daido Clinic
  - Nagoya-shi, Aichi, Japan, 466-8560
    - Nagoya University Hospital_Cardiology
  - Naha-shi, Okinawa, Japan, 902-8511
    - Naha City Hospital
  - Naha-shi, Okinawa, Japan, 902-8511
    - Naha City Hospital_Cardiovascular Medicine
  - Nara-shi, Nara, Japan, 630-8581
    - Nara Prefecture General Medical Center
  - Nara-shi, Nara, Japan, 630-8581
    - Nara Prefecture General Medical Center_Nephrology
  - Nishinomiya-shi, Hyogo, Japan, 662-0918
    - Hyogo Prefectual Nishinomiya Hospital_Nephrology
  - Oita-shi, Oita, Japan, 870-0263
    - Oita Medical Center_Cardiology
  - Okayama, Japan, 701-0192
    - Kawasaki Medical School Hospital_Nephrology
  - Omihachiman-shi, Siga, Japan, 523-0082
    - Omihachiman Community Medical Center_Omihachiman-shi, Siga
  - Omihachiman-shi, Siga, Japan, 523-0082
    - Omihachiman Community Medical Center_Cardiovascular Medicine
  - Osaka, Japan, 569-1045
    - Takatsuki Red Cross Hospital
  - Osaka, Japan, 564-0013
    - Saiseikai Suita Hospital_Cardiovascular Medicine
  - Osaka, Japan, 569-1045
    - Takatsuki Red Cross Hospital_Diabetes and Endocrine Div.
  - Osaka, Japan, 581-0011
    - Yao Tokushukai General Hospital_Cardiovascular division
  - Osaka-city, Osaka, Japan, 530-0005
    - Sakurabashi Watanabe Advanced Healthcare Hospital
  - Osaka-shi, Osaka, Japan, 538-0044
    - Kitada Clinic
  - Osaka-shi, Osaka, Japan, 533-0024
    - Yodogawa Christian Hospital_Cardiovascular medicine
  - Osaka-shi, Osaka, Japan, 534-0021
    - Osaka City General Hospital_Cardiology
  - Osaka-shi,Osaka, Japan, 559-0012
    - Social Corporation Keigakukai Minami Osaka Hospital_Cardiology
  - Ota-shi, Gunma, Japan, 373-8585
    - Ota Memorial Hospital
  - Ota-shi, Gunma, Japan, 373-8585
    - Ota Memorial Hospital_Cardiology
  - Sagamihara-shi, Kanagawa, Japan, 252-0375
    - Kitasato University Hospital_Sagamihara-shi, Kanagawa
  - Sagamihara-shi, Kanagawa, Japan, 252-0392
    - National Hospital Organization Sagamihara National Hospital
  - Sagamihara-shi, Kanagawa, Japan, 252-0375
    - Kitasato University Hospital_Cardiovascular Medicine
  - Sagamihara-shi, Kanagawa, Japan, 252-0392
    - National Hospital Organization Sagamihara National Hospital_Cardiology
  - Saitama-shi, Saitama, Japan, 338-0837
    - Sanai Hospital
  - Saitama-shi, Saitama, Japan, 338-0837
    - Sanai Hospital_Cardiology
  - Sapporo-shi, Hokkaido, Japan, 062-0003
    - Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine
  - Sendai-shi, Miyagi, Japan, 983-0039
    - Shinden Higashi Clinic
  - Sendai-shi, Miyagi, Japan, 980-8574
    - Tohoku University Hospital, Cardiovascular
  - Sendai-shi, Miyagi, Japan, 981-3133
    - Sendai Cardiovascular Center_Cardiology
  - Sendai-shi, Miyagi, Japan, 983-0039
    - Shinden Higashi Clinic_Internal medicine
  - Shizuoka, Japan, 430-0929
    - JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine
  - Suita-shi, Osaka, Japan, 564-0013
    - Saiseikai Suita Hospital_Suita-shi, Osaka
  - Suita-shi, Osaka, Japan, 565-0862
    - Osaka Saiseikai Senri Hospital
  - Suita-shi, Osaka, Japan, 565-0862
    - Osaka Saiseikai Senri Hospital_Cardiology
  - Tachikawa-shi, Tokyo, Japan, 190-0014
    - National Hospital Organization Disaster Medical Center_Nephrology
  - Takamatsu-shi, Kagawa, Japan, 760-0017
    - Takamatsu Red Cross Hospital_Cardiovascular Medicine
  - Takamatsu-shi, Kagawa, Japan, 760-8557
    - Kagawa Prefectural Central Hospital_Cardiovascular Medicine
  - Tokyo, Japan, 192-0918
    - Minamino Cardiovascular Hospital_Cardiovascular medicine
  - Tondabayashi-shi, Osaka, Japan, 584-0082
    - Saiseikai tondabayashi Hospital_Cardiology
  - Tsukuba-shi, Ibaraki, Japan, 305-8558
    - Tsukuba Medical Center Hospital_Department of Cardiology
  - Wakayama, Japan, 640-8558
    - Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology
  - Wako-shi, Saitama, Japan, 351-0102
    - National Hospital Organization Saitama Hospital
  - Wako-shi, Saitama, Japan, 351-0102
    - National Hospital Organization Saitama Hospital_Cardiology
  - Yokohama-shi, Kanagawa, Japan, 234-0054
    - Saiseikai Yokohamashi Nanbu Hospital_Cardiology
  - Yokohama-shi, Kanagawa, Japan, 236-0004
    - Yokohama City University Hospital
  - Yonezawa-shi, Yamagata, Japan, 992-0033
    - Sanyudo Hospital
  - Yonezawa-shi, Yamagata, Japan, 992-0033
    - Sanyudo Hospital_Cardiology
- Ehime
  - Uwajima-shi, Ehime, Japan, 798-8510
    - Uwajima City Hospital_ Cardiology
  - Uwajima-shi, Ehime, Japan, 798-8510
    - Uwajima City Hospital_Cardiology
- Fukushima, Japan
  - Koriyama-shi, Fukushima, Japan, Japan, 963-8851
    - Seino Internal Medicine Clinic
  - Koriyama-shi, Fukushima, Fukushima, Japan, Japan, 963-8851
    - Seino Internal Medicine Clinic_Internal medicine
- Kumamoto, Japan
  - Kumamoto, Kumamoto, Japan, Japan, 862-0976
    - Jinnouchi Hospital_Internal Medicine
- Miyazaki
  - Miyazaki, Miyazaki, Japan, 880-2102
    - Miyazaki Medical Association Hospital_Cardiology
Kina
- - Beijing, Kina, 100053
    - Xuanwu Hospital Capital Medical University-Cardiology
  - Changde, Kina, 415003
    - The First People's Hospital of Changde City -Internal Medicine-Cardiovascular
  - Chengdu, Kina, 610071
    - Sichuan Provincial People's Hospital- Nephrology
  - Hangzhou, Kina, 310003
    - The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology
  - Huizhou, Kina, 516001
    - Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept
  - Jinan, Kina, 250033
    - The Second Hospital of Shandong University
  - Jinan, Kina, 250013
    - Jinan Central Hospital Affiliated to Shandong University (Cardiovascular Dept)
  - Shantou, Kina, 515065
    - The Second Affiliated Hospital of Shantou University Medical College-Nephrology
  - Shenyang, Kina, 110136
    - Shengjing Hospital of China Medical University
- Anhui
  - Fuyang, Anhui, Kina, 236000
    - Fu Yang People's Hospital-Nephrology
  - Hefei, Anhui, Kina, 230601
    - The Second Hospital of Anhui Medical University
- Beijing Municipality
  - Beijing, Beijing Municipality, Kina, 100034
    - Peking University First Hospital
  - Beijing, Beijing Municipality, Kina, 100029
    - Beijing Anzhen Hospital, Capital Medical University
  - Beijing, Beijing Municipality, Kina, 100034
    - Peking University First Hospital-Cardiology
  - Beijing, Beijing Municipality, Kina, 100037
    - Chinese Academy of Medical Sciences Fuwai Hospital
  - Beijing, Beijing Municipality, Kina, 100053
    - Xuanwu Hospital Capital Medical University-Cardiology
  - Beijing, Beijing Municipality, Kina, 100191
    - Peking University Third Hospital-Cardiology
  - Beijing, Beijing Municipality, Kina, 100730
    - Beijing Hospital-Nephrology
  - Beijing, Beijing Municipality, Kina, 100853
    - Chinses People's Liberation Army General Hospital-Nephrology
  - Beijing, Beijing Municipality, Kina, 100853
    - Chinses PLA General Hospital-Nephrology
- Chongqing Municipality
  - Chongqing, Chongqing Municipality, Kina, 402260
    - The Second Affiliated Hospital of Chongqing Medical University-Cardiology
- Fujian
  - Xiamen, Fujian, Kina, 361004
    - Zhongshan Hospital Xiamen University-Nephrology
- Gansu
  - Lanzhou, Gansu, Kina, 730030
    - Lanzhou University Second Hospital_Internal Medicine-Cardiovascular Dept
  - Lanzhou, Gansu, Kina, 730030
    - The Second Hospital & Clinical Medical School, Lanzhou University-Internal Medicine & Cardiovascular
- Guangdong
  - Guangzhou, Guangdong, Kina, 510280
    - Zhujiang Hospital of Southern Medical University-Cardiology
  - Shantou, Guangdong, Kina, 515065
    - The Second Affiliated Hospital of Shantou University Medical College-Nephrology
  - Shenzhen, Guangdong, Kina, 518020
    - ShenZhen People's Hospital
- Guangxi
  - Nanning, Guangxi, Kina, 530016
    - The People's Hospital of Guangxi Zhuang Autonomous Region-Nephrology Department
- Hainan
  - Huizhou, Hainan, Kina, 516001
    - Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept
- Hebei
  - Xingtai, Hebei, Kina, 054031
    - Xingtai People's Hospital-Nephrology
- Henan
  - Luoyang, Henan, Kina, 471003
    - The First Affiliated Hospital of Henan University of Science and Technology-Nephrology
  - Xinxiang, Henan, Kina, 453000
    - The Third Affiliated Hospital of Xinxiang Medical University-Cardiology
  - Zhengzhou, Henan, Kina, 450052
    - The First Affiliated Hospital of Zhengzhou University
- Hubei
  - Wuhan, Hubei, Kina, 430060
    - Renmin Hospital of Wuhan University
  - Wuhan, Hubei, Kina, 430022
    - Wuhan Union Hospital-Cardiology
  - Wuhan, Hubei, Kina, 430030
    - Tongji Hospital, Tongji Medical College of HUST-Cardiology
  - Wuhan, Hubei, Kina, 430030
    - Tongji Hospital, Tongji Medical College of HUST-Nephrology
  - Wuhan, Hubei, Kina, 430060
    - Renmin Hospital of Wuhan University-Cardiology
- Hunan
  - Changde, Hunan, Kina, 415003
    - The First People's Hospital of Changde City -Internal Medicine-Cardiovascular
- Jiangsu
  - Changzhou, Jiangsu, Kina, 213003
    - Changzhou No.2 People's Hospital
  - Changzhou, Jiangsu, Kina, 213004
    - The First People's Hospital of Changzhou
  - Huai'an, Jiangsu, Kina, 223022
    - The Second People's Hospital of Huai'an-Nephrology
  - Nanjing, Jiangsu, Kina, 210009
    - Zhongda Hospital Southeast University
  - Nanjing, Jiangsu, Kina, 210011
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanning, Jiangsu, Kina, 530016
    - The People's Hospital of Guangxi Zhuang Autonomous Region-Cardiology Department
  - Suzhou, Jiangsu, Kina, 215006
    - The First Affiliated Hospital of Soochow University-Cardiology
  - Xuzhou, Jiangsu, Kina, 221002
    - The Affiliated Hospital of Xuzhou Medical University
  - Xuzhou, Jiangsu, Kina, 221002
    - The Affiliated Hospital of Xuzhou Medical University-Cardiology
  - Zhenjiang, Jiangsu, Kina, 212001
    - The Affiliated Hospital of Jiangsu University
  - Zhenjiang, Jiangsu, Kina, 212001
    - The Affiliated Hospital of Jiangsu University-Nephrology
- Jiangxi
  - Nanchang, Jiangxi, Kina, 330006
    - The First Affiliated Hospital of Nanchang University
  - Nanchang, Jiangxi, Kina, 330006
    - Jiangxi Provincial People's Hospital-Cardiology
  - Nanchang, Jiangxi, Kina, 330006
    - The First Affiliated Hospital of Nanchang University-Nephrology
- Jilin
  - Changchun, Jilin, Kina, 130033
    - China-Japan Union Hospital of Jilin University
  - Changchun, Jilin, Kina, 130033
    - China-Japan Union Hospital of Jilin University-Cardiology
  - Changchun, Jilin, Kina, 130033
    - The Second Hospital of Jilin University-Nephrology
  - Changchun, Jilin, Kina, 130033
    - The Second Hospital of Jilin University_Changchun
- Liaoning
  - Dalian, Liaoning, Kina, 116011
    - The First Affiliated Hospital of Dalian Medical University
  - Dalian, Liaoning, Kina, 116011
    - The First Affiliated Hospital of Dalian Medical University-Nephrology
  - Dalian, Liaoning, Kina, 116033
    - Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Cardiology
  - Dalian, Liaoning, Kina, 116033
    - Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Nephrology
  - Jinzhou, Liaoning, Kina, 121012
    - The First Affiliated Hospital of Jinzhou Medical University-Cardiology
  - Shenyang, Liaoning, Kina, 110136
    - Shengjing Hospital of China Medical University-Cardiology
- Shaanxi
  - Xi'an, Shaanxi, Kina, 710061
    - The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular
- Shandong
  - Jinan, Shandong, Kina, 250033
    - The Second Hospital of Shandong University
  - Jinan, Shandong, Kina, 250013
    - The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)-Cardiology
  - Jinan, Shandong, Kina, 250013
    - Jinan Central Hospital-Cardiovascular
- Shanghai Municipality
  - Shanghai, Shanghai Municipality, Kina, 200040
    - Huashan Hospital Fudan University
  - Shanghai, Shanghai Municipality, Kina, 200080
    - Shanghai General Hospital-Cardiology
  - Shanghai, Shanghai Municipality, Kina, 200092
    - Xinhua Hospital Affiliated to Shanghai Jiao Tong University-Nephrology
  - Shanghai, Shanghai Municipality, Kina, 200233
    - Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University-Nephrology
  - Shanghai, Shanghai Municipality, Kina, 201199
    - Central Hospital of Minhang District, Shanghai-Nephrology
- Shanxi
  - Linfen, Shanxi, Kina, 041099
    - Linfen Central Hospital-Cardiology
- Sichuan
  - Chengdu, Sichuan, Kina, 610071
    - Sichuan Provincial People's Hospital- Nephrology
- Tianjin Municipality
  - Tianjin, Tianjin Municipality, Kina, 300140
    - Tianjin 4th Center Hospital
  - Tianjin, Tianjin Municipality, Kina, 300122
    - Tianjin People's Hospital
- Yunnan
  - Kunming, Yunnan, Kina, 650033
    - The Second Affiliated Hospital of Kunming Medical University
- Zhejiang
  - Hangzhou, Zhejiang, Kina, 310014
    - Zhejiang Provincial People's Hospital
  - Hangzhou, Zhejiang, Kina, 310014
    - Zhejiang Provincial People's Hospital-Cardiology Department
  - Hangzhou, Zhejiang, Kina, 310003
    - The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology
Kroatien
- - Rijeka, Kroatien, 51000
    - KBC Rijeka, Zavod za kardiomiopatije
  - Rijeka, Kroatien, 51000
    - Clinical Hospital Centre Rijeka_Cardiology
  - Rijeka, Kroatien, 51000
    - Clinical Hospital Centre Rijeka_Nefrology
  - Split, Kroatien, 21000
    - KBC Split / Krizine/ Kardiologija
  - Zagreb, Kroatien, 10000
    - KBC Zagreb_Cardiology
  - Zagreb, Kroatien, 10000
    - KBC Zagreb_Nefrology
- City of Zagreb
  - Zagreb, City of Zagreb, Kroatien, 10000
    - Poliklinika Solmed
  - Zagreb, City of Zagreb, Kroatien, 10000
    - KB Dubrava, Zavod za bolesti srca i krvnih zila
- Krapinsko Zagorska County
  - Krapinske Toplice, Krapinsko Zagorska County, Kroatien, 49217
    - Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice_Cardiology
Letland
- - Daugavpils, Letland, 5417
    - Daugavpils Regional Hospital
  - Daugavpils, Letland, 5401
    - Ari Med
  - Jelgava, Letland, 3001
    - Zemgales diabetes centre
  - Riga, Letland, 1002
    - P. Stradins Clinical University hospital
  - Riga, Letland, 1011
    - Adoria
  - Riga, Letland, 1079
    - Riga East Clinical University Hospital - Clinic "Gailezers"
Litauen
- - Alytus, Litauen, 63200
    - Klinikiniai sprendimai, Alytus
  - Alytus, Litauen, LT-63200
    - Klinikiniai sprendimai, Alytus
  - Kaunas, Litauen, 50161
    - Hospital of Lithuanian University of Health Sciences Kauno klinikos
  - Kaunas, Litauen, 48259
    - Kaunas City Polyclinic, Silainiu department
  - Kaunas, Litauen, 49387
    - Klinikiniai sprendimai, Kaunas
  - Kaunas, Litauen, 49449
    - JSC "Saules seimos medicinos centras"
  - Kaunas, Litauen, LT-49387
    - Klinikiniai sprendimai, Kaunas
  - Kaunas, Litauen, LT-51270
    - Kaunas City polyclinic Dainava Branch
  - Kaunas, Litauen, 47144
    - Lithuanian university of health sciences Clinical hospital
  - Kaunas, Litauen, 51270
    - Kaunas City polyclinic Dainava Branch
  - Klaipėda, Litauen, 92288
    - Klaipeda University Hospital
  - Klaipėda, Litauen, LT-92288
    - Klaipeda University Hospital
  - Panevezys, Litauen, 35144
    - Republican Panevezys Hospital
  - Panevezys, Litauen, LT-35144
    - Republican Panevezys Hospital
  - Vilnius, Litauen, 08406
    - JSC Inlita Santaros
  - Vilnius, Litauen, 04130
    - JSC Inlita Lazdynai CMC
  - Šiauliai, Litauen, LT-76206
    - Pirmoji Viltis
Malaysia
- - Ipoh, Perak, Malaysia, 30450
    - Hospital Raja Permaisuri Bainun Ipoh
  - Kuala Lumpur, Malaysia, 50400
    - National Heart Institute
  - Pulau Pinang, Malaysia, 13700
    - Hospital Seberang Jaya
  - Sabak Bernam, Malaysia, 88300
    - Hospital Queen Elizabeth II
  - Seremban, Malaysia, 70300
    - Hospital Tuanku Jaafar
- Kedah
  - Alor Star, Kedah, Malaysia, 05460
    - Hospital Sultanah Bahiyah
  - Sungai Petani, Kedah, Malaysia, 08000
    - Hospital Sultan Abdul Halim
- Kelantan
  - Kota Bharu, Kelantan, Malaysia, 15586
    - Hospital Raja Perempuan Zainab II
  - Kota Bharu, Kelantan, Malaysia, 16150
    - Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan
- Kuala Lumpur
  - Cheras, Kuala Lumpur, Malaysia, 56000
    - Hospital Canselor Tuanku Muhriz UKM
  - Lembah Pantai, Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
- Perak
  - Ipoh, Perak, Malaysia, 30450
    - Hospital Raja Permaisuri Bainun Ipoh
  - Seri Manjung, Perak, Malaysia, 32040
    - Hospital Seri Manjung
- Sarawak
  - Kota Samarahan, Sarawak, Malaysia, 94300
    - Sarawak Heart Centre
  - Miri, Sarawak, Malaysia, 98000
    - Hospital Miri
- Selangor
  - Sungai Buloh, Selangor, Malaysia, 47000
    - University Technology MARA (UiTM) - Sg Buloh
Mexico
- - Aguascalientes, Mexico, 20230
    - Centro de Investigación Cardiometabólica de Aguascalientes
  - Querétaro, Mexico, 76000
    - Centro de Estudios Clínicos de Querétaro S.C.
  - Veracruz, Mexico, 91900
    - FAICIC S. de R.L. de C.V.
- Estado de Baja California
  - Tijuana, Estado de Baja California, Mexico, 22500
    - CINCAME
- Jalisco
  - Guadalajara, Jalisco, Mexico, 44670
    - Centro de Investigacion Clinica Endocrinologica de Jalisco
  - Guadalajara, Jalisco, Mexico, 44657
    - Consultorio Privado Dr Gabriel Arturo Ramos
- Mexico City
  - Benito Juárez, Mexico City, Mexico, 03300
    - Clinicos Asociados Bocm, S.C.
- México, D.F.
  - Mexico City, México, D.F., Mexico, 03300
    - Clinicos Asociados Bocm, S.C.
- Nuevo León
  - Monterrey, Nuevo León, Mexico, 64460
    - Unidad biomedica avanzada monterrey
  - Monterrey, Nuevo León, Mexico, 64060
    - Cardiolink Clin Trials S.C.
  - Monterrey, Nuevo León, Mexico, 64020
    - Internal Medicine Clin Trials
- San Luis Potosí
  - San Luis Potosí City, San Luis Potosí, Mexico, 78200
    - Centro de Atención e Investigación Cardiovascular del Potosí
- Sinaloa
  - Culiacán, Sinaloa, Mexico, 80230
    - Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.
  - Culiacán, Sinaloa, Mexico, 80230
    - Centro para el Desarrollo de la Medicina y la Asistencia
  - Culiacán, Sinaloa, Mexico, 80020
    - Hospital Angeles de Culiacan
Polen
- - Elblag, Polen, 82-300
    - Centrum Kliniczno Badawcze
  - Grodzisk Mazowiecki, Polen, 05-825
    - Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
  - Krakow, Polen, 31-202
    - Krakowski Szpital Specjalistyczny im. Jana Pawla II
  - Krakow, Polen, 30-082
    - Specjalistyczna Praktyka Lekarska L. Bryniarski
  - Krakow, Polen, 31-261
    - Praktyka Lekarska Mateusz Sidor
  - Lodz, Polen, 93-338
    - Instytut Centrum Zdrowia Matki Polki
  - Lodz, Polen, 90-338
    - Centrum Terapii Wspolczesnej
  - Lodz, Polen, 90-338
    - Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.
  - Lodz, Polen, 91-211
    - Salve Medica
  - Ogrodzieniec, Polen, 42-440
    - Specjalistyczna Praktyka Lekarska w Ogrodzieńcu
  - Poznan, Polen, 61-848
    - Uniwersytecki Szpital Kliniczny w Poznaniu
  - Puławy, Polen, 24-100
    - Velocity Nova Sp. z o.o.
  - Szczecin, Polen, 70-341
    - CENTRUM MEDYCZNE VITA Praktyka Kardiologiczna
  - Tychy, Polen, 43-100
    - Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach
  - Warsaw, Polen, 00-710
    - NBR Polska Tomasz Klodawski
  - Warsaw, Polen, 04-628
    - Narodowy Instytut Kardiologii Klin. Kard. i Ang.
  - Warsaw, Polen, 04-628
    - Narodowy Instytut Kardiologii Klin. Kard. i Transp.
  - Wroclaw, Polen, 51-162
    - Centrum Badan Klinicznych
  - Węgrów, Polen, 07-100
    - Szpital Powiatowy Im. Hrabiego Stanislawa Lubienskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej W Wegrowie
  - Zamość, Polen, 22-400
    - Velocity Nova Sp. z o.o. Velocity Zamosc
- Kuyavian-Pomeranian Voivodeship
  - Włocławek, Kuyavian-Pomeranian Voivodeship, Polen, 87-800
    - Kardio Life - Tomasz Borkowski
- Lesser Poland Voivodeship
  - Chrzanów, Lesser Poland Voivodeship, Polen, 32-500
    - Malopolskie Centrum Sercowo-Naczyniowe
  - Krakow, Lesser Poland Voivodeship, Polen, 31-261
    - Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
- Lower Silesian Voivodeship
  - Wroclaw, Lower Silesian Voivodeship, Polen, 50-981
    - 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
  - Wroclaw, Lower Silesian Voivodeship, Polen, 51-134
    - Zdrowie S.C. Agnieszka I Donald Drozdz
- Lublin Voivodeship
  - Lublin, Lublin Voivodeship, Polen, 20-044
    - NZOZ "CenterMed Lublin" Sp. z o.o.
  - Poniatowa, Lublin Voivodeship, Polen, 24-320
    - ETG Poniatowa
- Lubusz Voivodeship
  - Gorzów Wielkopolski, Lubusz Voivodeship, Polen, 66-400
    - Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
- Podlaskie Voivodeship
  - Bialystok, Podlaskie Voivodeship, Polen, 15-481
    - Kresmed Sp. z o. o.
  - Bialystok, Podlaskie Voivodeship, Polen, 15-540
    - Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio
- Pomeranian Voivodeship
  - Gdynia, Pomeranian Voivodeship, Polen, 81-157
    - Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
- Silesian Voivodeship
  - Ruda Śląska, Silesian Voivodeship, Polen, 41-710
    - AKA-MED Centrum
  - Ruda Śląska, Silesian Voivodeship, Polen, 41-710
    - Poradnia AKA-MED Centrum Sp. z o.o.
- Łódź Voivodeship
  - Lodz, Łódź Voivodeship, Polen, 90-549
    - Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
Portugal
- - Almada, Portugal, 2805-267
    - ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta
  - Aveiro, Portugal, 3814-501
    - ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro
  - Braga, Portugal, 4710-243
    - ULS De Braga, E.P.E. - Hospital de Braga
  - Coimbra, Portugal, 3000-561
    - Unidade Local de Saúde de Coimbra, E.P.E.
  - Guilhufe - Penafiel, Portugal, 4560-136
    - ULS De Tâmega e Sousa E.P.E. - Hospital Padre Américo
  - Lisbon, Portugal, 1449-005
    - Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital São Francisco Xavier
  - Lisbon, Portugal, 1649-035
    - Unidade Local De Saúde De Santa Maria E.P.E.
  - Lisbon, Portugal, 1250-230
    - APDP - Associação Protectora dos Diabéticos de Portugal
  - Porto, Portugal, 4200-319
    - ULS De São João, E.P.E. - Hospital de São João
  - Setúbal, Portugal, 2910-446
    - ULS Da Arrábida, E.P.E._Hospital de São Bernardo
  - Viana do Castelo, Portugal, 4904-858
    - ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia
  - Vila Nova de Gaia, Portugal, 4434-502
    - ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva
- Lisbon District
  - Carnaxide, Lisbon District, Portugal, 2790-134
    - Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital de Santa Cruz
- Matosinhos
  - Senhora Da Hora, Matosinhos, Matosinhos, Portugal, 4464-513
    - ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
Rumænien
- - Baia Mare, Rumænien, 430222
    - Cabinet Medical de Cardiologie Dr. Calin Pop
  - Brasov, Rumænien, 500283
    - Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
  - Brasov, Rumænien, 500091
    - S.C. Centrul Medical Unirea S.R.L.
  - Brăila, Rumænien, 810325
    - Spitalul Judetean de Urgenta Braila
  - Bucharest, Rumænien, 050098
    - Spitalul Universitar de Urgenta Bucuresti
  - Bucharest, Rumænien, 011461
    - Spitalul Universitar de Urgenta Elias
  - Bucharest, Rumænien, 020475
    - Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila
  - Bucharest, Rumænien, 021875
    - Davius Clinicmed Srl
  - Bucharest, Rumænien, 011053
    - Hightech Medical Services S.R.L.
  - Bucharest, Rumænien, 012292
    - Lotus Med SRL
  - Bucharest, Rumænien, 014146
    - Centrul Medical Emerald
  - Bucharest, Rumænien, 042122
    - Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti
  - Bucharest, Rumænien, 020339
    - Donna Medplus S.R.L.
  - Buzău, Rumænien, 120133
    - Mat Cord Biomedica S.R.L.
  - Constanța, Rumænien, 900591
    - Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
  - Craiova, Rumænien, 200383
    - Neurocord Medical SRL
  - Craiova, Rumænien, 200513
    - Cardiomed SRL
  - Galati, Rumænien, 800291
    - SC Diamed Obesity SRL
  - Iași, Rumænien, 700503
    - Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"
  - Iași, Rumænien, 700547
    - SC Consultmed SRL
  - Iași, Rumænien, 700732
    - SC Cardiomed SRL
  - Oradea, Rumænien, 410469
    - Spitalul Clinic Judetean De Urgenta Bihor
  - Paşcani, Rumænien, 705200
    - Bella Praxis S.R.L.
  - Piteşti, Rumænien, 110424
    - Sc Sal Med Srl
  - Timișoara, Rumænien, 300310
    - Institutul de Boli Cardiovasculare Timișoara
  - Timișoara, Rumænien, 300254
    - Spitalul Clinic Municipal de Urgenta Timisoara
  - Târgu Mureş, Rumænien, 540136
    - Spitalul Clinic Judetean de Urgenta Targu Mures
  - Târgu Mureş, Rumænien, 540143
    - CMI Dr. Cristian Podoleanu
- Bucharest
  - Bucharest, Bucharest, Rumænien, 022328
    - Institutul Clinic Fundeni
- Bucurestii
  - Bucharest, Bucurestii, Rumænien, 020475
    - Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila
- Cluj
  - Cluj-Napoca, Cluj, Rumænien, 400006
    - Clinic of Diabetes Cluj
Rusland
- - Barnaul, Rusland, 656055
    - RBSHI "Altay Regional Cardiology Dispensary"
  - Barnaul, Rusland, 656024
    - Reg. State Budget Healthc. Inst. Regional Clinical Hospital
  - Chelyabinsk, Rusland, 454048
    - Road Clinical Hospital at station Chelyabinsk
  - Chita, Rusland, 672000
    - Chita State Medical Academy
  - Irkutsk, Rusland, 664049
    - Irkutsk State Medical Academy of Postgraduate Education
  - Kazan', Rusland, 420029
    - FSB EI "Kazan' State Medical University"
  - Kazan', Rusland, 420101
    - SAI of Health "Interregional Clinic Diagnostic Center"
  - Kemerovo, Rusland, 650002
    - Institute of Complex Problems of Cardio-Vascular Diseases
  - Moscow, Rusland, 129226
    - Pirogov Russian National Research Medical University MoH
  - Moscow, Rusland, 129327
    - Friendship University of Russia MCCH base
  - Moscow, Rusland, 121552
    - National Medical Research Center of Cardiology
  - Novosibirsk, Rusland, 630087
    - State Novosibirsk regional clinical hospital
  - Novosibirsk, Rusland, 630099
    - Limited Law Company "Healthy Family" Medicine Center"
  - Novosibirsk, Rusland, 630005
    - LLC RC Medical
  - Perm, Rusland, 614068
    - SBIH Perm region "City Clinical Hospital #2 n.a. F.K. Gral"
  - Petrozavodsk, Rusland, 185019
    - Republican Hospital n.a. V. A. Baranov
  - Saint Petersburg, Rusland, 196084
    - Medical Research Institute LLC
  - Saint Petersburg, Rusland, 199106
    - SPb BHI "City Pokrovskaya Hospital"
  - Samara, Rusland, 443070
    - Regional Clinical cardiological dispensary n.a. Polyakov
  - Sochi, Rusland, 354057
    - City Hospital #4, Sochi
  - Tomsk, Rusland, 634034
    - Tomsk National Research Medical Center of the RAS
  - Tomsk, Rusland, 634012
    - Tomsk National Research Medical Center of the RAS
Serbien
- - Belgrade, Serbien, 11080
    - Clinical Hospital Centre Zemun
  - Belgrade, Serbien, 11000
    - Clinical centre of Serbia, Clinic for cardiology
  - Belgrade, Serbien, 11000
    - Endocrinology, Diabetes and Metabolism Diseases Clinic
  - Belgrade, Serbien, 11000
    - Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
  - Belgrade, Serbien, 11000
    - Emergency Internal Medicine Clinic
  - Belgrade, Serbien, 11000
    - CHC Zvezdara, Clinical department for endocrinology
  - Belgrade, Serbien, 11000
    - Institute for Cardiovascular Diseases ''Dedinje''
  - Kamenitz, Serbien, 21204
    - Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica
  - Kragujevac, Serbien, 34000
    - Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department
  - Niš, Serbien, 18108
    - University Clinical Centre Nis, Clinic for Cardiology
  - Novi Sad, Serbien, 21000
    - Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
- Vojvodina
  - Novi Sad, Vojvodina, Serbien, 21000
    - Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
Slovakiet
- - Bratislava, Slovakiet, 811 04
    - CARDIOCONSULT, s.r.o.
  - Bratislava, Slovakiet, 81369
    - I. Interna klinika LF UK a UNB
  - Bratislava, Slovakiet, 831 06
    - DIABEDA s.r.o.
  - Bratislava, Slovakiet, 83348
    - Klinika kardiologie a angiologie LF SZU
  - Bratislava, Slovakiet, 841 03
    - CINRE s. r. o., Oddelenie akutnej kardiologie a koronarna JIS
  - Bratislava, Slovakiet, 83305
    - 1. Interna klinika SZU a UNB
  - Košice, Slovakiet, 040 01
    - Medical group Kosice s.r.o.
  - Levice, Slovakiet, 934 01
    - VITAL, s.r.o.
  - Lučenec, Slovakiet, 984 01
    - KARDIO 1, s.r.o., Kardiologicka ambulancia
  - Martin, Slovakiet, 036 59
    - 1. interna klinika, Univerzitna nemocnica Martin
  - Nitra, Slovakiet, 949 11
    - InterStom, s.r.o.
  - Nové Zámky, Slovakiet, 940 01
    - KARDIOMED NZ, s.r.o.
  - Piešťany, Slovakiet, 92101
    - Medical KG, s.r.o.
  - Považská Bystrica, Slovakiet, 017 01
    - Kardiologicka ambulancia
  - Prešov, Slovakiet, 08-181
    - FNsP J. A. Reimana Presov, Klinika kardiologie
  - Prešov, Slovakiet, 080 01
    - IMCORE, s.r.o.
  - Ľubochňa, Slovakiet, 03491
    - Narodny Endokrinologicky a diabetologicky ustav
Spanien
- - Barakaldo, Spanien, 48903
    - Hospital Universitario de Cruces
  - Castilleja de la Cuesta, Spanien, 41950
    - Hospital Vithas Sevilla
  - Córdoba, Spanien, 14004
    - Hospital Reina Sofia
  - L' Hospitalet Del Llobregat, Spanien, 08907
    - Bellvitge Universitary Hospital
  - Sanlúcar de Barrameda, Spanien, 11540
    - H Virgen del Camino_Sanlúcar_Medicina Interna
  - Valencia, Spanien, 46010
    - Hospital Clinico Universitario de Valencia
  - Valencia, Spanien, 46017
    - Hospital Universitario Doctor Peset
  - Villamartín, Spanien, 11650
    - Hosp. Virgen de las Montañas_Medicina Interna
  - Zaragoza, Spanien, 50009
    - Hospital Univ. Miguel Servet_Medicina Interna
- Madrid
  - Majadahonda, Madrid, Spanien, 28222
    - Hospital Universitario Puerta de Hierro Majadahonda
- Murcia
  - El Palmar, Murcia, Spanien, 30120
    - Hospital Univ. Virgen de la Arrixaca
Sverige
- - Gothenburg, Sverige, 413 45
    - Njurmedicin Sahlgrenska - SU
  - Lund, Sverige, 222 21
    - Clemenstorgets Hjartmottagning
  - Malmo, Sverige, 205 02
    - Forskningsmottagning Internmedicin (tidigare KFE)
  - Stockholm, Sverige, 171 64
    - Karolinska Universitetssjukhuset Solna,FOU Tema Hjärta Kärl
  - Uppsala, Sverige, 751 85
    - Forskning njurmedicin Uppsala
  - Örebro, Sverige, 70185
    - Njursektionen Medicinkliniken Örebro UH
- Stockholm County
  - Huddinge, Stockholm County, Sverige, 141 85
    - Karolinska Universitetssjukhuset, Huddinge
Sydafrika
- Eastern Cape
  - George, Eastern Cape, Sydafrika, 6529
    - Excellentis Clinical Trial Consultants
- Free State
  - Bloemfontein, Free State, Sydafrika, 9301
    - Josha Research
  - Bloemfontein, Free State, Sydafrika, 9301
    - Iatros International
  - Bloemfontein, Free State, Sydafrika, 9301
    - Cardiology Research_Bloemfontein
- Gauteng
  - Centurion, Gauteng, Sydafrika, 0157
    - Dr Iftikhar Osman Ebrahim
  - Johannesburg, Gauteng, Sydafrika, 2193
    - Wits Clinical Research
  - Johannesburg, Gauteng, Sydafrika, 2013
    - Wits Bara Clinical Trial Site
  - Johannesburg, Gauteng, Sydafrika, 2157
    - Tickerdoc Research (Pty) LTD
  - Pretoria, Gauteng, Sydafrika, 0184
    - Synexus Watermeyer Clinical Research Centre
  - Pretoria, Gauteng, Sydafrika, 0183
    - Jongaie Research
  - Pretoria, Gauteng, Sydafrika, 0186
    - Clinical Trial Systems (CTC)
  - Pretoria, Gauteng, Sydafrika, 0002
    - EMMED Clinical Research
  - Roodepoort, Gauteng, Sydafrika, 1724
    - Roodepoort Medicross Clinical Research Centre
- KwaZulu-Natal
  - Tongaat, KwaZulu-Natal, Sydafrika, 4400
    - Mediclinic Medical Centre
- Western Cape
  - Cape Town, Western Cape, Sydafrika, 7530
    - Tiervlei Trial Centre
  - Cape Town, Western Cape, Sydafrika, 7500
    - Tread Research (Pty)Ltd
  - Cape Town, Western Cape, Sydafrika, 7925
    - Prof Rayner_Division of Nephrology
  - Cape Town, Western Cape, Sydafrika, 7130
    - Helderberg Research Institute
  - George, Western Cape, Sydafrika, 6529
    - TASK Eden Clinical Research Centre
  - Mossel Bay, Western Cape, Sydafrika, 6500
    - Dr Hendrik Snyman's Practice
  - Paarl, Western Cape, Sydafrika, 7646
    - Paarl Reserch Centre
  - Paarl, Cape Town, Western Cape, Sydafrika, 7646
    - Paarl Research Centre
  - Somerset West, Western Cape, Sydafrika, 7130
    - Synexus Helderberg Clinical Research Centre
  - Somerset West, Western Cape, Sydafrika, 7130
    - Clinical Trials Network Helderberg
Sydkorea
- - Busan, Sydkorea, 49201
    - Dong-A University Hospital
  - Busan, Sydkorea, 49241
    - Pusan National University Hospital
  - Busan, Sydkorea, 49201
    - Dong-A University Medical Center
  - Daegu, Sydkorea, 42601
    - Keimyung University Dongsan Hospital
  - Daegu, Sydkorea, 42601
    - Keimyung University Dongsan Medical Center
  - Daegu, Sydkorea, 42472
    - Daegu Catholic Univ. Medical Center
  - Daejeon, Sydkorea, 35015
    - Chungnam National University Hospital
  - Gangwon-do, Sydkorea, 26426
    - Wonju Severance Christian Hospital
  - Goyang, Sydkorea, 410-719
    - National Health Insurance Corporation Ilsan Hospital
  - Gwangju, Sydkorea, 61469
    - Chonnam National University Hospital
  - Gyeonggi-do, Sydkorea, 471-101
    - Hanyang University Guri Hospital
  - Gyeonggi-do, Sydkorea, 14068
    - Hallym UMC_Pyeongchon
  - Incheon, Sydkorea, 21565
    - Gachon University Gil Medical Center
  - Seoul, Sydkorea, 03080
    - Seoul National University Hospital
  - Seoul, Sydkorea, 01830
    - Nowon Eulji Medical Center, Eulji University
  - Seoul, Sydkorea, 03722
    - Severance Hospital, Yonsei University Health System
  - Seoul, Sydkorea, 05278
    - Kyung Hee University Hospital at Gangdong
  - Seoul, Sydkorea, 06591
    - The Catholic University of Korea, Seoul St. Mary's Hospital
  - Seoul, Sydkorea, 02841
    - Korea University Anam Hospital
  - Seoul, Sydkorea, 08308
    - Korea University Guro Hospital
  - Seoul, Sydkorea, 05030
    - Konkuk University Medical Center
  - Seoul, Sydkorea, 02447
    - KyungHee University Medical Center
  - Seoul, Sydkorea, 06591
    - Seoul Saint Mary's Hospital
  - Seoul, Sydkorea, 07441
    - KangNam Sacred Heart Hospital
- Gyeonggi-do
  - Goyang-si, Gyeonggi-do, Sydkorea, 10444
    - National Health Insurance Corporation Ilsan Hospital
  - Seongnam-si, Gyeonggi-do, Sydkorea, 13620
    - Seoul National University Bundang Hospital
Taiwan
- - Hsinchu, Taiwan, 300
    - HsinChu MacKay Memorial Hospital
  - Kaohsiung City, Taiwan, 807
    - Kaohsiung Medical University Chung-Ho Memorial Hospital
  - Kaohsiung City, Taiwan, 82445
    - E-DA Hospital-Department of Cardiology
  - Tainan, Taiwan, 704
    - National Cheng Kung University Hospital
  - Tainan, Taiwan, 710
    - Chi Mei Medical Center
  - Taipei, Taiwan, 110
    - Taipei Medical University Hospital
  - Taipei, Taiwan, 112
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 112
    - Cheng Hsin General Hospital
  - Taipei, Taiwan, 100
    - National Taiwan University Hospital_main
  - Taoyuan District, Taiwan, 333
    - Chang Gung Memorial Hospital, Linkou
  - Yilan, Taiwan, 260006
    - National Yang Ming Chiao Tung University Hospital Lanyang Campus
Thailand
- - Bangkok, Thailand, 10330
    - King Chulalongkorn Memorial Hospital
  - Bangkok, Thailand, 10700
    - Siriraj Hospital
  - Bangkok, Thailand, 10300
    - Cardio-Vajira
  - Bangkok, Thailand, 10300
    - Vajira Hospital - Cardio
  - Bangkok, Thailand, 10210
    - Chulabhorn hospital_Cardiovascular
  - Chiang Mai, Thailand, 50200
    - Maharaj Nakorn Chiang Mai Hospital
  - Chiang Mai, Thailand, 50200
    - Rihes - Research Institute for Health Sciences
  - Chiang Mai, Thailand, 50200
    - RIHES-CMU_Research Institute for Health Sciences
  - Khon Kaen, Thailand, 40002
    - Srinagarind Hospital
  - Nakhon Ratchasima, Thailand, 30000
    - Maharat Nakhon Ratchasima Hospital
  - Pathum Thani, Thailand, 12120
    - Thammasat Hospital_Cardiology
  - Songkhla, Thailand, 90110
    - Songklanagarind Hospital
  - Ubon Ratchathani, Thailand, 34000
    - Sunpasitthiprasong Hospital
  - Ubon Ratchathani, Thailand, 34000
    - Sunpasitthiprasong Hospital_Pediatrics Department
- Bangkok
  - Bangkok Noi, Bangkok, Thailand, 10700
    - Siriraj Hospital
- Changwat Pathum Thani
  - Klong Luang, Pathumthani, Changwat Pathum Thani, Thailand, 12120
    - Thammasat University Hospital
- Changwat Songkhla
  - Hat Yai, Changwat Songkhla, Thailand, 90110
    - Songklanagarind Hospital
- Mueang Chiang Mai
  - Chiang Mai, Mueang Chiang Mai, Thailand, 50200
    - Maharaj Nakorn Chiang Mai Hospital_Nephrology
- Patumwan
  - Bangkok, Patumwan, Thailand, 10330
    - King Chulalongkorn Memorial Hospital
- Rajathewee
  - Bangkok, Rajathewee, Thailand, 10400
    - Phramongkutklao Hospital_Nephrology
- Thung Phayathai Subdistrict
  - Bangkok, Thung Phayathai Subdistrict, Thailand, 10400
    - Ramathibodi Hospital
Tjekkiet
- - Broumov, Tjekkiet, 550 01
    - Edumed Broumov
  - Liberec, Tjekkiet, 460 01
    - KARDIOLOGIE - LIBEREC s.r.o.
  - Náchod, Tjekkiet, 547 01
    - EDUMED s.r.o.
  - Prague, Tjekkiet, 170 00
    - Medicon a.s.
  - Prague, Tjekkiet, 140 21
    - IKEM Klinika nefrologie
  - Slaný, Tjekkiet, 274 01
    - Nemocnice Slany
Tyrkiet (Türkiye)
- - Afyonkarahisar, Tyrkiet (Türkiye), 03200
    - Afyonkarahisar Health Sciences University
  - Afyonkarahisar, Tyrkiet (Türkiye), 03200
    - Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
  - Ankara, Tyrkiet (Türkiye), 06230
    - Hacettepe Universitesi Tip Fakultesi Nefroloji Bilim Dali
  - Ankara, Tyrkiet (Türkiye), 06230
    - Hacettepe University Medical Faculty_Ankara
  - Ankara, Tyrkiet (Türkiye), 06230
    - Hacettepe Üniversitesi Hastanesi- Kardiyoloji
  - Ankara, Tyrkiet (Türkiye), 06230
    - Hacettepe Üniversitesi Hastanesi- Nefroloji
  - Ankara, Tyrkiet (Türkiye), 06800
    - Ankara Bilkent Şehir Hastanesi-Kardiyoloji
  - Antalya, Tyrkiet (Türkiye), 07058
    - Akdeniz Universitesi Hastanesi Nefroloji Bilim Dali
  - Antalya, Tyrkiet (Türkiye), 07058
    - Akdeniz Üniversitesi Hastanesi-Nefroloji
  - Aydin, Tyrkiet (Türkiye), 09100
    - Aydın Adnan Menderes Üniversitesi Hastanesi- Nefroloji
  - Edirne, Tyrkiet (Türkiye), 22030
    - Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
  - Eskişehir, Tyrkiet (Türkiye), 26040
    - Eskisehir Osmangazi University-Cardio
  - Eskişehir, Tyrkiet (Türkiye), 26040
    - Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
  - Istanbul, Tyrkiet (Türkiye), 34381
    - Istanbul Florence Nightingale Hospital
  - Istanbul, Tyrkiet (Türkiye), 34668
    - Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
  - Istanbul, Tyrkiet (Türkiye), 34098
    - İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü
  - Izmir, Tyrkiet (Türkiye), 35100
    - Ege Üniversitesi Hastanesi- Kardiyoloji
  - Izmir, Tyrkiet (Türkiye), 35340
    - Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji
  - Kahramanmaraş, Tyrkiet (Türkiye), 46040
    - Kahramanmaraş Sütçü İmam University
  - Kayseri, Tyrkiet (Türkiye), 38039
    - Erciyes University Medial Faculty
  - Kocaeli, Tyrkiet (Türkiye), 41380
    - Kocaeli University Nephrology Department
  - Kocaeli, Tyrkiet (Türkiye), 41380
    - Kocaeli Üniversitesi Araştıma ve Uygulama Hastanesi - Nefroloji
  - Mersin, Tyrkiet (Türkiye), 33343
    - Mersin Üniversitesi Hastanesi- Kardiyoloji
  - Muğla, Tyrkiet (Türkiye), 48050
    - Muğla Eğitim Ve Araştırma Hastanesi
- Bakirkoy
  - Istanbul, Bakirkoy, Tyrkiet (Türkiye), 34153
    - Istanbul University Cerrahpasa Medical Faculty
  - Istanbul, Bakirkoy, Tyrkiet (Türkiye), 34098
    - İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Nefroloji
- Melikgazi
  - Kayseri, Melikgazi, Tyrkiet (Türkiye), 38039
    - Erciyes Üniversitesi Hastanesi - Nefroloji
Tyskland
- - Aachen, Tyskland, 52074
    - Universitaetsklinikum Aachen AöR
  - Aachen, Tyskland, 52074
    - Uniklinik Aachen - Med. Klinik I
  - Bad Homburg, Tyskland, 61348
    - Kardiologische Praxis, Bad Homburg
  - Berlin, Tyskland, 12203
    - Charité - Campus Benjamin Franklin - Klinik für Nephrologie und Internistische Intensivmedizin
  - Dessau, Tyskland, 06846
    - Praxis Dr.med. Frank Menzel
  - Dresden, Tyskland, 01307
    - Herzzentrum Dresden GmbH Universitaetsklinik
  - Dresden, Tyskland, 01277
    - Kreutzmann
  - Dresden, Tyskland, 01307
    - Uniklinik TU Dresden - Herzzentrum Dresden GmbH
  - Dresden, Tyskland, 01277
    - Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
  - Dresden, Tyskland, 01099
    - Facharztzentrum Dresden Betriebsgesellschaft mbH
  - Düsseldorf, Tyskland, 40210
    - DaVita Clinical Research Deutschland GmbH
  - Elsterwerda, Tyskland, 04910
    - Zentrum fuer Klinische Studien Suedbrandenburg GmbH
  - Essen, Tyskland, 45136
    - InnoDiab Forschung Gmbh
  - Falkensee, Tyskland, 14612
    - Zentrum für klinische Forschung, Dr. med. Lüdemann
  - Frankfurt, Tyskland, 60389
    - MVZ CCB Frankfurt und Main-Taunus GbR
  - Frankfurt, Tyskland, 60590
    - Nephrologie Universitätsklinikum Frankfurt
  - Frankfurt, Tyskland, 60596
    - Studienzentrum ClinPhenomics
  - Frankfurt, Tyskland, 60590
    - Uniklinik FFM - Nephrologie
  - Freiburg im Breisgau, Tyskland, 79100
    - Nierenzentrum Freiburg
  - Halle, Tyskland, 06120
    - Universitätsklinikum Halle - Innere Medizin II
  - Heidelberg, Tyskland, 69115
    - St. Josefskrankenhaus Heidelberg - Diabeteszentrum
  - Homburg, Tyskland, 66421
    - Universität des Saarlandes - Innere Med. III
  - Homburg Saar, Tyskland, 66421
    - Universität des Saarlandes - Innere Med. IV
  - Jena, Tyskland, 07747
    - University Hospital Jena KöR
  - Jena, Tyskland, 07747
    - Uniklinik Jena - Kardiologie
  - Lübeck, Tyskland, 23538
    - Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
  - Mainz, Tyskland, 55131
    - Marienhaus Klinikum Mainz GmbH - Innere Medizin I
  - Mainz, Tyskland, 55131
    - Universitätsmedizin der JGU Mainz - Kardiologie I
  - Mannheim, Tyskland, 68165
    - zero PRAXEN Mannheim-Schwetzingerstadt
  - Reichelsheim, Tyskland, 61203
    - Praxis Reichelsheim
  - Witten, Tyskland, 58455
    - Kahrmann
  - Witten, Tyskland, 58455
    - Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
- Baden-Wurttemberg
  - Freiburg im Breisgau, Baden-Wurttemberg, Tyskland, 79106
    - Universitätsklinikum Freiburg - Medical Center
  - Karlsbad, Baden-Wurttemberg, Tyskland, 76307
    - SRH Klinikum Karlsbad-Langensteinbach GmbH - Innere Medizin
- Holstein
  - Oldenburg in Holstein, Holstein, Tyskland, 23758
    - RED-Institut für medizinische Forschung und Fortbildung GmbH
- Thuringia
  - Coburg, Thuringia, Tyskland, 96450
    - Sana Kliniken Oberfranken Coburg GmbH - II. Med. Klinik, Kardiologie
Ukraine
- - Chernivtsi, Ukraine, 58023
    - Reg Clin Hospital of Emergency Care, Bukovinian Medical Univ
  - Chernivtsi, Ukraine, 58023
    - Chernivtsi Emergency Hospital - Therapeutic Department No.1
  - Ivano-Frankivsk, Ukraine, 76008
    - Сlinical treatment and diagnostic centre 'Simedgroup'
  - Kharkiv, Ukraine, 61039
    - NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable
  - Kharkiv, Ukraine, 61178
    - Municipal Non-Profit Institution "City Clinical Hospital #8"
  - Kharkiv, Ukraine, 61002
    - City Clinical Hospital #27 (Kharkiv) - Intensive care department
  - Kharkiv, Ukraine, 61039
    - Institute of Therapy named after L.T.Malaya - Department of Prevention and Treatment of Kidney Diseases in Comorbid Conditions
  - Kharkiv, Ukraine, 61178
    - City Clinical Hospital #8 (Kharkiv) - Dept of Arterial and Ven Thrombosis
  - Kyiv, Ukraine, 03037
    - Medbud-Clinic LLC
  - Kyiv, Ukraine, 02660
    - Kyiv City Clinical Hospital of Emergency Care - Infarction
  - Kyiv, Ukraine, 03049
    - Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz
  - Kyiv, Ukraine, 03049
    - Kyiv Railway Clinical Hospital #2 - day care department
  - Kyiv, Ukraine, 02660
    - Kyiv City Clinical Hospital of Emergency Care - Infarction department
  - Kyiv, Ukraine, 03037
    - "Medbud-Clinic" LLC - medical and preventive unit
  - Kyiv, Ukraine, 02091
    - Medical Centre "OkClinic +" - inpatient department
  - Kyiv, Ukraine, 03151
    - M.D.Strazheska Institute of Cardiology of NAMSU - Intensive care and resuscitation department
  - Kyiv, Ukraine, 03680
    - M.D.Strazheska Institute of Cardiology of NAMSU - Department of non-coronary heart diseases
  - Kyiv, Ukraine, 04050
    - Medical Center 'Consilium Medical' - clinical consultation department
  - Kyiv, Ukraine, 04053
    - Kyiv Regional Clinical Hospital - Consultative medical department
  - Kyiv, Ukraine, 04210
    - "Center of Family Medicine Plus" LLC - Outpatient department
  - Zaporizhia, Ukraine, 69001
    - City Clinical Hospital #10 (Zaporizhia) - Therapeutics department
  - Zaporizhzhia, Ukraine, 69063
    - University Clinic of Zaporizhia State Medical and Pharm University - Cardiology department
  - Zhytomyr, Ukraine, 10002
    - Central City Hospital #1 - Scientific-Research centre
Ungarn
- - Baja, Ungarn, 6500
    - EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
  - Balatonfüred, Ungarn, 8230
    - Tagore Medical Center
  - Budapest, Ungarn, 1204
    - Jahn Ferenc Del-pesti Korhaz es Rendelointezet
  - Budapest, Ungarn, 1096
    - Gottsegen György Országos Kardiológiai Intézet
  - Debrecen, Ungarn, 4032
    - DE KK Kardiológiai és Szívsebészeti klinika
  - Szeged, Ungarn, 6725
    - Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
- Bekes County
  - Békéscsaba, Bekes County, Ungarn, 5600
    - Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
- Komárom-Esztergom
  - Komárom, Komárom-Esztergom, Ungarn, 2921
    - Selye János Kórház
- Zala County
  - Zalaegerszeg, Zala County, Ungarn, 8900
    - Léda Platán Magánklinika

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Estimeret glomerulær filtrationshastighed (eGFR) 15 og under 60 ml/min/1,73 m^2 (ved brug af Kreatinin-ligningen for Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI))
Serum højfølsomt C-reaktivt protein (hs-CRP) større end eller lig med 2 mg/L ved screening (besøg 1)
Bevis for aterosklerotisk kardiovaskulær sygdom (ASCVD) ved en eller flere af følgende:
a) Koronar hjertesygdom defineret som mindst én af følgende: i. Dokumenteret historie om MI ii. Forudgående koronar revaskulariseringsprocedure iii. større end eller lig med 50 % stenose i epikardisk koronararterie, dokumenteret ved hjertekateterisering eller CT koronar angiografi b) Cerebrovaskulær sygdom defineret som mindst én af følgende: i. Tidligere slagtilfælde af aterosklerotisk oprindelse ii. Forudgående procedure for revaskularisering af halspulsåren iii. større end eller lig med 50 % stenose i halspulsåren dokumenteret ved røntgenangiografi, MR angiografi, CT angiografi eller Doppler ultralyd.
c) Symptomatisk perifer arteriesygdom (PAD) defineret som mindst én af følgende: i. Claudicatio intermittens med et ankel-brachialindeks (ABI) under eller lig med 0,90 i hvile ii. Claudicatio intermittens med en større end eller lig med 50 % stenose i perifer arterie (eksklusive carotis) dokumenteret ved røntgenangiografi, MR angiografi, CT angiografi eller Doppler ultralyd iii. Tidligere perifer arterie (eksklusive carotis) revaskulariseringsprocedure iv. Amputation af underekstremiteter ved eller over ankel på grund af aterosklerotisk sygdom (undtagen f.eks. traumer eller osteomyelitis).

Ekskluderingskriterier:

Klinisk bevis for eller mistanke om aktiv infektion efter investigators skøn.
Myokardieinfarkt, slagtilfælde, hospitalsindlæggelse for ustabil angina pectoris eller forbigående iskæmisk anfald inden for 60 dage før randomisering (besøg 2).
Planlagt koronar-, carotis- eller perifer arterie-revaskularisering kendt på screeningsdagen (besøg 1).
Større hjertekirurgisk, ikke-hjertekirurgisk eller større endoskopisk procedure (thorakoskopisk eller laparoskopisk) inden for de seneste 60 dage forud for randomisering (besøg 2) eller enhver større kirurgisk procedure, der er planlagt på tidspunktet for randomiseringen (besøg 2).

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Firedobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Ziltivekimab Deltagerne vil modtage Ziltivekimab B eller Ziltivekimab C subkutant én gang om måneden i op til 4 år.	Medicin: Ziltivekimab B Indgivet subkutant (s.c., under huden) en gang om måneden tilføjet til standardbehandling. Medicin: Ziltivekimab C Indgivet subkutant (s.c., under huden) en gang om måneden tilføjet til standardbehandling.
Placebo komparator: Placebo Deltagerne vil modtage enten placebo (Ziltivekimab B) eller placebo (Ziltivekimab C) subkutant én gang om måneden i op til 4 år.	Medicin: Placebo (Ziltivekimab B) Indgivet subkutant (s.c., under huden) en gang om måneden tilføjet til standardbehandling. Medicin: Placebo (Ziltivekimab C) Indgivet subkutant (s.c., under huden) en gang om måneden tilføjet til standardbehandling.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til første forekomst af 3-punkts Major Adverse Cardiovascular Event (MACE), et sammensat endepunkt bestående af: Kardiovaskulær (CV) død, ikke-dødelig myokardieinfarkt (MI) og ikke-dødelig slagtilfælde Tidsramme: Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)	Måneder	Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)

Sekundære resultatmål

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Novo Nordisk A/S

Efterforskere

Studieleder: Clinical Transparency (dept. 2834), Novo Nordisk A/S

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

30. august 2021

Primær færdiggørelse (Anslået)

9. juni 2026

Studieafslutning (Anslået)

9. juni 2026

Datoer for studieregistrering

Først indsendt

19. august 2021

Først indsendt, der opfyldte QC-kriterier

19. august 2021

Først opslået (Faktiske)

26. august 2021

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

13. april 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

7. april 2026

Sidst verificeret

1. april 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

EX6018-4758
U1111-1259-3422 (Anden identifikator: World Health Organization (WHO))
jRCT2021210033 (Registry Identifier: JAPIC)
2023-506926-35 (Anden identifikator: European Medical Agency (EMA))

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Ifølge Novo Nordisks oplysningsforpligtelse på novonordisk-trials.com

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Betændelse

Istanbul Bilgi University

Tilmelding efter invitation

Effekter af Dietary Inflammatory Index på systemiske inflammationsmarkører og gastrointestinale symptomer hos personer med fedmekirurgi

Systemisk inflammation | Bariatrisk kirurgi | Bariatrisk ærmegatrektomi | Diætbetændelsesindeks (DII) | Systemiske inflammationsmarkører | Inflammation

Tyrkiet (Türkiye)
Biogen

Rekruttering

En undersøgelse for at lære om virkningerne af Felzartamab-infusioner på voksne med nyretransplantationer, der har sen isoleret mikrovaskulær inflammation (TRANSPIRE)

Mikrovaskulær inflammation

Forenede Stater, Østrig, Spanien, Tyskland, Frankrig, Brasilien, Tjekkiet
Ankara City Hospital Bilkent

Ikke rekrutterer endnu

Evaluering af irisin-niveauer ved underarmsfraktur-kirurgi hos voksne under infraklavikulær blok og generel anæstesi

Angiogenese | Healing | Inflammation
Cornell University
PATH; Institut Pasteur de Madagascar; Université d'Antananarivo

Ikke rekrutterer endnu

Effekten af en Cricket og Black Soldier Fly Larver-beriget kiks på tarmmikrobiomet og jernstatus hos skolebørn i Madagaskar

Jernoptagelse | Tarm - Mikrobiota | Inflammation

Madagaskar
Center for Research and Innovation Viña Concha...
Universidad Católica del Maule

Ikke rekrutterer endnu

Resveratrols effekt på inflammatoriske biomarkører og kardiometaboliske parametre. (RESINCA)

Inflammatorisk | Antioxidantstatus, inflammation | Inflammation biomarkører | Antioxidant evner | Cardiometabolic sundhedsindikatorer

Chile
University of Arkansas, Fayetteville

Afsluttet

Effekten af Vand med Antiinflammatoriske Egenskaber på den Inflammatoriske Reaktion på Tung Modstandsøvelse (WAC)

Systemisk inflammation | Hydrering | Hvilemetabolisme

Forenede Stater
Elazıg Fethi Sekin Sehir Hastanesi

Rekruttering

Effekter af spinal vs. generel anæstesi på systemisk inflammation i PCNL (PCNL-ANES-INF)

Systemisk inflammation | Perkutan nefrolitotomi | Anæstesiteknikker

Tyrkiet (Türkiye)
University of California, Los Angeles

Rekruttering

En mindfulness-baseret intervention til at reducere stress gennem dyrkelse af venlighed, medfølelse, glæde og ligevægt hos sundhedsfaglige professionelle (FIERCE)

Psykosocial funktion | Stress (psykologi) | Inflammation

Forenede Stater
Poznan University of Physical Education

Afsluttet

Effekten af en enkelt træningssession på ændringer i inflammatoriske, hormonelle og metaboliske markører hos atleter.

Uddannelse | Motionstræning | Hormon | Inflammation biomarkører

Polen
University Hospital, Martin

Aktiv, ikke rekrutterende

DARA-MVI-studiet (Daratumumab mod mikrovaskulær inflammation ved nyretransplantation) (DARA-MVI)

Mikrovaskulær Inflammation - MVI hos Nyretransplantatmodtagere

Slovakiet

Kliniske forsøg med Ziltivekimab B

Novo Nordisk A/S

Afsluttet

En forskningsundersøgelse, der ser på blodniveauer af tre forskellige formuleringer af undersøgelsesmedicinen Ziltivekimab

Sunde deltagere

Ungarn, Holland
Novo Nordisk A/S

Rekruttering

Et forskningsstudie til at undersøge effekten af Ziltivekimab på plak i hjertets blodkar, sammenlignet med placebo, hos personer med et hjerteanfald (ZEPHYR)

Myokardieinfarkt

Holland, Østrig, Italien, Spanien, Danmark, Schweiz
Novo Nordisk A/S
Sponsor: Corvidia Therapeutics Inc, a subsidiary of Novo Nordisk A/S

Afsluttet

Forsøg til evaluering af reduktion i inflammation hos patienter med avanceret kronisk nyresygdom ved brug af antistofmedieret IL-6-hæmning i Japan. (RESCUE-2)

Betændelse | Kronisk nyresygdom | Kardiovaskulær risiko

Japan
Novo Nordisk A/S

Rekruttering

En forskningsundersøgelse for at se på, hvordan Ziltivekimab virker sammenlignet med placebo hos mennesker med hjertesvigt og betændelse (HERMES)

Hjertefejl

Forenede Stater, Australien, Kina, Spanien, Det Forenede Kongerige, Italien, Estland, Serbien, Argentina, Malaysia, Holland, Østrig, Singapore, Thailand, Taiwan, Sydafrika, Canada, Indien, Mexico, Brasilien, Frankrig, Litauen, Ungarn, ... og mere
Novo Nordisk A/S

Afsluttet

En forskningsundersøgelse af, hvordan medicinen Ziltivekimab virker i kroppen hos kinesiske mænd og kvinder med nyresygdomme og -betændelse

Kronisk nyresygdom og systemisk inflammation

Kina
Novo Nordisk A/S
Duke Clinical Research Institute

Rekruttering

ARTEMIS - En forskningsundersøgelse for at se på, hvordan Ziltivekimab virker sammenlignet med placebo hos mennesker, der har haft et hjerteanfald (ARTEMIS)

Kardiovaskulær risiko | Akut myokardieinfarkt (AMI)

Canada, Forenede Stater, Spanien, Australien, Argentina, Italien, Kina, Det Forenede Kongerige, Tjekkiet, Bulgarien, Holland, Grækenland, Malaysia, Polen, Brasilien, Indien, Mexico, Japan, Tyskland, Danmark, Frankrig, Sydkorea, Tyrkiet... og mere
ECRI bv
Novo Nordisk A/S; Cardialysis B.V.; Insel Gruppe AG, University Hospital...

Rekruttering

Effekter af Ziltivekimab på koronar aterosklerotisk byrde hos patienter med akut myokardieinfarkt (ZEPHYR)

Koronararteriesygdom | Akut myokardieinfarkt (AMI) | Koronar åreforkalkning af indfødt koronararterie

Schweiz
Novo Nordisk A/S

Rekruttering

En forskningsundersøgelse, der ser på, hvordan Ziltivekimab virker sammenlignet med placebo hos deltagere med hjertesvigt og betændelse (ATHENA)

Hjertefejl | Systemisk inflammation

Forenede Stater, Malaysia, Australien, Argentina, Indien, Canada, Spanien, Det Forenede Kongerige, Polen, Frankrig, Grækenland, Portugal, Tyskland, Bulgarien, Tjekkiet, Tyrkiet (Türkiye)
Novo Nordisk A/S

Afsluttet

Forsøg for at evaluere reduktion i inflammation hos patienter med avanceret kronisk nyresygdom ved brug af antistofmedieret IL-6-hæmning (RESCUE)

Betændelse | Kroniske nyresygdomme

Forenede Stater
Academisch Medisch Centrum - Universiteit van Amsterdam...

Rekruttering

Specificering af de antiinflammatoriske virkninger af Ziltivekimab (SPIDER)

Betændelse | Åreforkalkning

Holland

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til første forekomst af hver af de individuelle komponenter i det udvidede MACE-endepunkt og det sammensatte nyre-endepunkt. Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Måneder	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Tid til første forekomst af MI (fatal og ikke-dødelig). Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Måneder	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Tid til første forekomst af slagtilfælde (dødelig og ikke-dødelig). Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Måneder	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Tid til første forekomst af koronar revaskularisering Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Måneder	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Ændring i urinabumin-til-ceatinin-forholdet (UACR). Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder).	Procent	Fra randomisering (måned 0) til 2 år (24 måneder).
Ændring i eGFR (CKD-EPI)) Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder)	ml/min/1,73 m^2	Fra randomisering (måned 0) til 2 år (24 måneder)
Årlig ændringshastighed i eGFR (CKD-EPI) (samlet eGFR-hældning) Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	ml/min/1,73 m^2/år	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Ændring i højfølsomt C-reaktivt protein (hs-CRP) Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder).	Procent	Fra randomisering (måned 0) til 2 år (24 måneder).
Ændring i N-terminal-pro-hjerne natriuretisk peptid (NT-pro-BNP) Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder)	Procent	Fra randomisering (måned 0) til 2 år (24 måneder)
Ændring i venstre ventrikulær ejektionsfraktion (LVEF) Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder)	Procent	Fra randomisering (måned 0) til 2 år (24 måneder)
Antal hændelser af atrieflimren Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Tælle	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Antal indlæggelser med infektion som primær årsag eller død som følge af infektion. Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Tælle	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Ændring i Short Form 36 (SF-36) Physical Component Score (PCS) Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder)	Score på skala	Fra randomisering (måned 0) til 2 år (24 måneder)
Tid til første forekomst af udvidet MACE, et sammensat endepunkt bestående af: CV død, ikke-fatal MI, ikke-dødelig slagtilfælde og hospitalsindlæggelse for ustabil angina pectoris, der kræver akut koronar revaskularisering Tidsramme: Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)	Måneder	Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)
Antal hjertesvigtsindlæggelser eller akutte hjertesvigtsbesøg eller CV-dødsfald Tidsramme: Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)	Tælle	Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)
Ændring i hæmoglobin Tidsramme: Fra randomisering (måned 0) til 2 år (24 måneder)	Gram pr. deciliter (g/dL)	Fra randomisering (måned 0) til 2 år (24 måneder)
Tid til første forekomst af et sammensat nyreendepunkt bestående af: CV død, begyndende vedvarende mindst 40 procent (%) reduktion i eGFR (CKD-epidemiologisk samarbejde [CKD-EPI]) sammenlignet med baseline, nyresvigt Tidsramme: Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)	Måneder	Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)
Tid til forekomst af dødelighed af alle årsager Tidsramme: Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)	Måneder	Fra randomisering (måned 0) til afslutning af studiet (op til 48 måneder)
Tid til første forekomst af et sammensat MACE-endepunkt bestående af: dødelighed af alle årsager, ikke-dødelig MI og ikke-dødelig slagtilfælde Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Måneder	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).
Tid til første forekomst af et 4-komponent nyreendepunkt bestående af: begyndende vedvarende mindst 40 % reduktion i eGFR (CKD-EPI) sammenlignet med baseline, nyresvigt Tidsramme: Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).	Måneder	Fra randomisering (måned 0) til studieafslutning (op til 48 måneder).

ZEUS - En forskningsundersøgelse for at se på, hvordan Ziltivekimab virker sammenlignet med placebo hos mennesker med hjerte-kar-sygdomme, kronisk nyresygdom og betændelse (ZEUS)

ZEUS - Effekter af Ziltivekimab versus placebo på kardiovaskulære resultater hos deltagere med etableret aterosklerotisk kardiovaskulær sygdom, kronisk nyresygdom og systemisk inflammation

Studieoversigt

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Studerer et amerikansk FDA-reguleret lægemiddelprodukt

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produkt fremstillet i og eksporteret fra U.S.A.

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