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ZEUS - Uno studio di ricerca per esaminare come funziona Ziltivekimab rispetto al placebo nelle persone con malattie cardiovascolari, malattie renali croniche e infiammazioni (ZEUS)

7 aprile 2026 aggiornato da: Novo Nordisk A/S

ZEUS - Effetti di Ziltivekimab rispetto al placebo sugli esiti cardiovascolari nei partecipanti con malattia cardiovascolare aterosclerotica accertata, malattia renale cronica e infiammazione sistemica

Questo studio è condotto per vedere se ziltivekimab riduce il rischio di avere eventi cardiovascolari (ad esempio infarto e ictus) nelle persone con malattie cardiovascolari, malattie renali croniche e infiammazione.

I partecipanti riceveranno ziltivekimab (medicinale attivo) o placebo (un medicinale fittizio che non ha alcun effetto sul corpo). Questo è noto come il medicinale dello studio. Quale trattamento ricevono i partecipanti viene deciso per caso. La possibilità dei partecipanti di ottenere ziltivekimab o placebo è la stessa.

Ziltivekimab non è ancora approvato in nessun paese o regione del mondo. È una nuova medicina che i medici non possono prescrivere.

I partecipanti riceveranno il medicinale in studio in una siringa preriempita. I partecipanti dovranno utilizzare la siringa preriempita per iniettare il medicinale in studio in una plica una volta al mese.

Lo studio dovrebbe durare fino a 4 anni. I partecipanti avranno fino a 20 visite cliniche. I partecipanti riceveranno campioni di sangue e urina prelevati durante la maggior parte delle visite cliniche.

Ai partecipanti verrà esaminato il cuore utilizzando onde sonore (ecocardiografia) ed elettrodi (elettrocardiogramma).

Le donne non possono partecipare in caso di gravidanza, allattamento o pianificazione di una gravidanza durante il periodo di studio.

Panoramica dello studio

Stato

Attivo, non reclutante

Condizioni

Intervento / Trattamento

Tipo di studio

Interventistico

Iscrizione (Stimato)

6200

Fase

  • Fase 3

Contatti e Sedi

Questa sezione fornisce i recapiti di coloro che conducono lo studio e informazioni su dove viene condotto lo studio.

Luoghi di studio

  • Argentina
      • Buenos Aires, Argentina, C1425AGC
        • Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli
      • Buenos Aires, Argentina, B6000BHA
        • Centro Medico Lebensohn
      • CABA, Argentina, C1120AAC
        • Centro Medico Viamonte SRL
      • Capital Federal, Argentina, C1431FWO
        • Centro de Educación Médica e Investigaciones Clínicas Saaved
      • Ciudad Autónoma de Buenos Aire, Argentina, 1425
        • Cardiología Palermo Duplicate
      • Córdoba, Argentina, X5003DCE
        • Instituto Medico DAMIC
      • Quilmes - Buenos Aires, Argentina, B1878DVB
        • Instituto Medico CER
      • San Miguel de Tucumán, Tucumán., Argentina, T4000
        • Investigaciones Clinicas Tucuman
      • San Nicolás, Argentina, B2900
        • Instituto de Investigaciones Clinicas San Nicolas
    • Buenos Aires
      • CABA, Buenos Aires, Argentina, C1128 AAF
        • Mautalen Salud e Investigacion
      • CABA, Buenos Aires, Argentina, C1440CFD
        • CEMEDIC
      • CABA, Buenos Aires, Argentina, C1213
        • Sanatorio Finochietto
      • CABA, Buenos Aires, Argentina, C1428ART
        • Instituto Cardiovascular Buenos Aires
      • La Plata, Buenos Aires, Argentina, B 1900AXI
        • Hospital Italiano de La Plata
      • Mar del Plata, Buenos Aires, Argentina, B7600GNY
        • Centro de Investigaciones Médicas Clínica de Fracturas y Or
      • Mar del Plata, Buenos Aires, Argentina, B7600GNY
        • Centro de Investigaciones Medicas Mar Del Plata
  • Australia
    • Australian Capital Territory
      • Garran, Australian Capital Territory, Australia, 2605
        • Canberra Hospital
      • Garran, Australian Capital Territory, Australia, 2605
        • The Canberra Hospital_Garran
    • New South Wales
      • Gosford, New South Wales, Australia, 2250
        • Gosford Renal Research
      • Kogarah, New South Wales, Australia, 2217
        • St George Hospital
      • St Leonards, New South Wales, Australia, 2065
        • Royal North Shore Hospital
      • Westmead, New South Wales, Australia, 2145
        • Westmead Applied Research Centre
      • Wollongong, New South Wales, Australia, 2500
        • Illawarra Heart Health Centre
    • Queensland
      • Birtinya, Queensland, Australia, 4575
        • Sunshine Coast University Hospital
      • Milton, Queensland, Australia, 4064
        • Core Research Group
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Nightingale Research
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital Cardiovascular Clinical Trials
      • Adelaide, South Australia, Australia, 5000
        • Royal Adelaide Hospital - Cardiology Department
      • Leabrook, South Australia, Australia, 5068
        • Advara HeartCare Leabrook
      • Leabrook, South Australia, Australia, 5068
        • HeartCare SA
    • Tasmania
      • Hobart, Tasmania, Australia, 7000
        • Royal Hobart Hospital
    • Victoria
      • Clayton, Victoria, Australia, 3168
        • Monash Health Heart
      • Fitzroy, Victoria, Australia, 3065
        • St Vincent's Hospital_Fitzroy_0
      • Geelong, Victoria, Australia, 3220
        • Geelong Cardiology Research Unit
      • Reservoir, Victoria, Australia, 3073
        • Melbourne Renal Research Group
      • St Albans, Victoria, Australia, 3021
        • Sunshine Hospital
      • St Albans, Victoria, Australia, 3021
        • Sunshine Hospital - Western Centre for Health Research and Education
      • Traralagon, Victoria, Australia, 3844
        • Latrobe Regional Hospital - Research Unit
    • Western Australia
      • Joondalup, Western Australia, Australia, 6027
        • Advara HeartCare Joondalup
      • Joondalup, Western Australia, Australia, 6027
        • HeartCare WA (Joondalup)
  • Belgio
      • Aalst, Belgio, 9300
        • AZORG Aalst - Moorselbaan
      • Bonheiden, Belgio, 2820
        • Imeldaziekenhuis - Bonheiden - Department of Endocrinology
      • Brasschaat, Belgio, 2930
        • AZ Klina - Brasschaat - Cardiology
      • Bruges, Belgio, 8000
        • AZ Sint-Jan - Campus Brugge_Brugge
      • Bruges, Belgio, 8000
        • AZ Sint-Jan - Campus Brugge
      • Genk, Belgio, 3600
        • Ziekenhuis Oost-Limburg AV - Cardiology
      • Genk, Belgio, 3600
        • Ziekenhuis Oost Limburg - Cardiology
      • Kortrijk, Belgio, 8500
        • AZ Groeninge - Kortrijk - Cardiology
      • Liège, Belgio, 4000
        • CHR de la Citadelle
      • Mechelen, Belgio, 2800
        • AZ Sint-Maarten Mechelen - Cardiology
      • Ostend, Belgio, 8400
        • AZ OOSTENDE (Campus DAMIAAN)
  • Brasile
      • Porto Alegre/ RS, Brasile, 90035-074
        • Irmandade da Santa Casa de Misericordia de Porto Alegre
      • Salvador, Brasile, 41810-011
        • HBA S/A Assistência Médica e Hospitalar
      • São Bernardo Do Campo/SP, Brasile, 09715-090
        • CEMEC - Centro Multidisciplinar de Estudos Clínicos
      • São Paulo - SP, Brasile, 04038-002
        • Centro de Diabetes e Obesidade - HRim e Hipertensao
    • Espírito Santo
      • Vitória, Espírito Santo, Brasile, 29055-450
        • Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo
    • Federal District
      • Brasília, Federal District, Brasile, 70390-700
        • Hospital do Coracao do Brasil
    • Minas Gerais
      • Belo Horizonte, Minas Gerais, Brasile, 30110-934
        • Hospital Felício Rocho
      • Uberlândia, Minas Gerais, Brasile, 38400-500
        • Eurolatino Medical Research Center
    • Paraná
      • Curitiba, Paraná, Brasile, 80730-150
        • Núcleo de Pesquisa Clínica S/S
      • Curitiba, Paraná, Brasile, 80440-020
        • Instituto Pró-Renal Brasil
    • Santa Catarina
      • Blumenau, Santa Catarina, Brasile, 89020-430
        • AngioCor Blumenau
    • São Paulo
      • Campinas, São Paulo, Brasile, 13060-080
        • Instituto de Pesquisa Clinica de Campinas
      • Campinas, São Paulo, Brasile, 13092-133
        • i9 Pesquisas Clínicas
      • Campinas, São Paulo, Brasile, 13060-803
        • PUCCAMP - Hospital e Maternidade Celso Pierro
      • Santo André, São Paulo, Brasile, 09090-790
        • Praxis Pesquisa Médica
      • São José do Rio Preto, São Paulo, Brasile, 15090-000
        • CIP Centro Integrado de Pesquisas do Hospital de Base
      • São Paulo, São Paulo, Brasile, 01228-000
        • CPQuali Pesquisa Clinica Ltda
      • São Paulo, São Paulo, Brasile, 01409-902
        • Impar Servicos Hospitalares S/A
      • São Paulo, São Paulo, Brasile, 05403-000
        • Instituto do Coracao - HCFMUSP
      • Votuporanga, São Paulo, Brasile, 15500-269
        • INTEGRAL Pesquisa e Ensino
  • Bulgaria
      • Dimitrovgrad, Bulgaria, 6400
        • Medical Centre Diamedical-2013
      • Dimitrovgrad, Bulgaria, 6400
        • MC Diamedical - 2013 OOD, Dimitrovgrad
      • Kyustendil, Bulgaria, 2500
        • 'Medical center Medi city 21' OOD
      • Kyustendil, Bulgaria, 2500
        • Medical center Medi City 21 OOD
      • Montana, Bulgaria, 3400
        • MC Hera EOOD - Montana
      • Pernik, Bulgaria, 2300
        • SHATC Sveti Georgi - Pernik OOD
      • Pleven, Bulgaria, 5800
        • Medical center Medconsult Pleven OOD
      • Pleven, Bulgaria, 5800
        • "Medical center Medconsult Pleven" OOD
      • Pleven, Bulgaria, 5804
        • MHAT Heart and Brain
      • Pleven, Bulgaria, 5804
        • MHAT Heart and Brain EAD - Pleven, Cardiology
      • Plovdiv, Bulgaria, 4002
        • UMHAT Sveti Georgi EAD, Plovdiv, Clinic of Cardiology
      • Sliven, Bulgaria, 8800
        • 'MHAT Hadzhi Dimitar' OOD
      • Sliven, Bulgaria, 8800
        • MHAT Hadzhi Dimitar OOD
      • Sofia, Bulgaria, 1309
        • MHAT National Cardiology Hospital EAD
      • Sofia, Bulgaria, 1431
        • UMHAT "Sveti Ivan Rilski"
      • Sofia, Bulgaria, 1407
        • "Acibadem City Clinic UMHAT" EOOD, Sofia, Cardiology clinic
      • Sofia, Bulgaria, 1750
        • "UMHAT "Sveta Anna" Sofia" AD, Clinic of Cardiology
      • Sofia, Bulgaria, 1750
        • "UMHAT "Sveta Anna" Sofia"
      • Sofia, Bulgaria, 1431
        • DCC Aleksandrovska EOOD
      • Sofia, Bulgaria, 1309
        • Mhat "Nch"
      • Sofia, Bulgaria, 1527
        • Medical center ISUL - Tsaritsa Yoanna EOOD
      • Sofia, Bulgaria, 1431
        • UMHAT Sveti Ivan Rilski EAD, Nephrology
      • Sofia, Bulgaria, 1415
        • Acibadem City Clinic UMHAT EOOD, Cardiology
      • Sofia, Bulgaria, 1510
        • MC Hera EOOD - Sofia
      • Sofia, Bulgaria, 1750
        • UMHAT Sveta Anna Sofia AD, Clinic of Cardiology
      • Sofia, Bulgaria, 1750
        • UMHAT Sveta Anna Sofia AD, Second Clinic of Internal Diseases
      • Stara Zagora, Bulgaria, 6001
        • Medical Center "Nov Rehabilitatsionen center" EOOD
      • Stara Zagora, Bulgaria, 6000
        • Prevencia - 2000 - MCOC OOD
      • Stara Zagora, Bulgaria, 6001
        • Medical Center Nov Rehabilitatsionen center EOOD
      • Varna, Bulgaria, 9010
        • UMHAT Sveta Marina EAD, Second Clinic of Cardiology
      • Yambol, Bulgaria, 8600
        • MC Berbatov EOOD, Cherni Drin
  • Canada
      • Québec, Canada, G1V 4G5
        • Institut universitaire de cardiologie
      • Québec, Canada, G1V4G2
        • CHU de Quebec-Universite Laval
      • Québec, Canada, G1G 5X1
        • Recherche Clinique Sigma inc
    • Alberta
      • Calgary, Alberta, Canada, T2H 2G4
        • LMC Clin Res Inc. Calgary
      • Calgary, Alberta, Canada, T2V 4J2
        • C-Health Partners
      • Sherwood Park, Alberta, Canada, T8H 0N2
        • Synergy Wellness Clinic
    • British Columbia
      • Vancouver, British Columbia, Canada, V5Y 3W2
        • BC Diabetes Canada
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • Nova Scotia Hlth Halifax
    • Ontario
      • Barrie, Ontario, Canada, L4N 7L3
        • LMC Diabetes & Endocrinology (Barrie)
      • Brampton, Ontario, Canada, L6S 0C6
        • LMC ClinRsrh Inc.Brampton
      • Cambridge, Ontario, Canada, N1R 6V6
        • Cambridge Cardiac Care Centre
      • Concord, Ontario, Canada, L4K 4M2
        • LMC Clin Res Inc. Thornhill
      • Etobicoke, Ontario, Canada, M9R 4E1
        • Centricity Research Etobicoke Endocrinology
      • Hamilton, Ontario, Canada, L8L 5G4
        • Premier Clinical Trial Research Network (PCTRN)
      • Mississauga, Ontario, Canada, L4Y 1M3
        • One Heart Care
      • Nepean, Ontario, Canada, K2J 0V2
        • LMC Research Inc. Ottawa
      • Newmarket, Ontario, Canada, L3Y 2P6
        • Partnrs Adv Cardio Eval (PACE)
      • North York, Ontario, Canada, M6B 3H7
        • North York Diagn & Cardiac Ctr
      • Oakville, Ontario, Canada, L6M 1M1
        • LMC Clinical Research Inc. Oakville
      • Oakville, Ontario, Canada, L6K 3W7
        • Oakville Cardiovascular Research LP
      • Peterborough, Ontario, Canada, K9J 0B2
        • Kawartha Cardiology Clinical Trials
      • Scarborough Village, Ontario, Canada, M1B 4Z8
        • Heart Health Institute Research, Inc.
      • Toronto, Ontario, Canada, M6G 1M2
        • Diabetes Heart Research Centre
      • Toronto, Ontario, Canada, M4G 3E8
        • LMC Endo Centres Ltd.(Bayview)
      • Waterloo, Ontario, Canada, N2T 0C1
        • Clinical Research Solutions Inc.
    • Quebec
      • Brossard, Quebec, Canada, J4Z-2K9
        • Viacar Recherche Clinique Inc.
      • Laval, Quebec, Canada, H7T 2P5
        • Ctr de recherche Clinique de Laval
      • Longueuil, Quebec, Canada, J4H4B9
        • Viacar Recherche Clinique Inc.
      • Sherbrooke, Quebec, Canada, J1H 5N4
        • Centre de Recherche du CHUS
      • Terrebonne, Quebec, Canada, J6V 2H2
        • Centre de santé et de services
  • Cechia
      • Broumov, Cechia, 550 01
        • Edumed Broumov
      • Liberec, Cechia, 460 01
        • KARDIOLOGIE - LIBEREC s.r.o.
      • Náchod, Cechia, 547 01
        • EDUMED s.r.o.
      • Prague, Cechia, 170 00
        • Medicon a.s.
      • Prague, Cechia, 140 21
        • IKEM Klinika nefrologie
      • Slaný, Cechia, 274 01
        • Nemocnice Slany
  • Cina
      • Beijing, Cina, 100053
        • Xuanwu Hospital Capital Medical University-Cardiology
      • Changde, Cina, 415003
        • The First People's Hospital of Changde City -Internal Medicine-Cardiovascular
      • Chengdu, Cina, 610071
        • Sichuan Provincial People's Hospital- Nephrology
      • Hangzhou, Cina, 310003
        • The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology
      • Huizhou, Cina, 516001
        • Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept
      • Jinan, Cina, 250033
        • The Second Hospital of Shandong University
      • Jinan, Cina, 250013
        • Jinan Central Hospital Affiliated to Shandong University (Cardiovascular Dept)
      • Shantou, Cina, 515065
        • The Second Affiliated Hospital of Shantou University Medical College-Nephrology
      • Shenyang, Cina, 110136
        • Shengjing Hospital Of China Medical University
    • Anhui
      • Fuyang, Anhui, Cina, 236000
        • Fu Yang People's Hospital-Nephrology
      • Hefei, Anhui, Cina, 230601
        • The second hospital of Anhui medical university
    • Beijing Municipality
      • Beijing, Beijing Municipality, Cina, 100034
        • Peking University First Hospital
      • Beijing, Beijing Municipality, Cina, 100029
        • Beijing Anzhen Hospital, Capital Medical University
      • Beijing, Beijing Municipality, Cina, 100034
        • Peking University First Hospital-Cardiology
      • Beijing, Beijing Municipality, Cina, 100037
        • Chinese Academy of Medical Sciences Fuwai Hospital
      • Beijing, Beijing Municipality, Cina, 100053
        • Xuanwu Hospital Capital Medical University-Cardiology
      • Beijing, Beijing Municipality, Cina, 100191
        • Peking University Third Hospital-Cardiology
      • Beijing, Beijing Municipality, Cina, 100730
        • Beijing Hospital-Nephrology
      • Beijing, Beijing Municipality, Cina, 100853
        • Chinses People's Liberation Army General Hospital-Nephrology
      • Beijing, Beijing Municipality, Cina, 100853
        • Chinses PLA General Hospital-Nephrology
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, Cina, 402260
        • The Second Affiliated Hospital of Chongqing Medical University-Cardiology
    • Fujian
      • Xiamen, Fujian, Cina, 361004
        • Zhongshan Hospital Xiamen University-Nephrology
    • Gansu
      • Lanzhou, Gansu, Cina, 730030
        • Lanzhou University Second Hospital_Internal Medicine-Cardiovascular Dept
      • Lanzhou, Gansu, Cina, 730030
        • The Second Hospital & Clinical Medical School, Lanzhou University-Internal Medicine & Cardiovascular
    • Guangdong
      • Guangzhou, Guangdong, Cina, 510280
        • Zhujiang Hospital of Southern Medical University-Cardiology
      • Shantou, Guangdong, Cina, 515065
        • The Second Affiliated Hospital of Shantou University Medical College-Nephrology
      • Shenzhen, Guangdong, Cina, 518020
        • ShenZhen People's Hospital
    • Guangxi
      • Nanning, Guangxi, Cina, 530016
        • The People's Hospital of Guangxi Zhuang Autonomous Region-Nephrology Department
    • Hainan
      • Huizhou, Hainan, Cina, 516001
        • Huizhou Central People's Hospital_Internal Medicine-Cardiovascular Dept
    • Hebei
      • Xingtai, Hebei, Cina, 054031
        • Xingtai People's Hospital-Nephrology
    • Henan
      • Luoyang, Henan, Cina, 471003
        • The First Affiliated Hospital of Henan University of Science and Technology-Nephrology
      • Xinxiang, Henan, Cina, 453000
        • The Third Affiliated Hospital of Xinxiang Medical University-Cardiology
      • Zhengzhou, Henan, Cina, 450052
        • The First Affiliated Hospital of Zhengzhou University
    • Hubei
      • Wuhan, Hubei, Cina, 430060
        • Renmin Hospital of Wuhan University
      • Wuhan, Hubei, Cina, 430022
        • Wuhan Union Hospital-Cardiology
      • Wuhan, Hubei, Cina, 430030
        • Tongji Hospital, Tongji Medical College of HUST-Cardiology
      • Wuhan, Hubei, Cina, 430030
        • Tongji Hospital, Tongji Medical College of HUST-Nephrology
      • Wuhan, Hubei, Cina, 430060
        • Renmin Hospital of Wuhan University-Cardiology
    • Hunan
      • Changde, Hunan, Cina, 415003
        • The First People's Hospital of Changde City -Internal Medicine-Cardiovascular
    • Jiangsu
      • Changzhou, Jiangsu, Cina, 213003
        • Changzhou No.2 People's Hospital
      • Changzhou, Jiangsu, Cina, 213004
        • The First People's Hospital of Changzhou
      • Huai'an, Jiangsu, Cina, 223022
        • The Second People's Hospital of Huai'an-Nephrology
      • Nanjing, Jiangsu, Cina, 210009
        • Zhongda Hospital Southeast University
      • Nanjing, Jiangsu, Cina, 210011
        • The Second Affiliated Hospital of Nanjing Medical University
      • Nanning, Jiangsu, Cina, 530016
        • The People's Hospital of Guangxi Zhuang Autonomous Region-Cardiology Department
      • Suzhou, Jiangsu, Cina, 215006
        • The First Affiliated Hospital of Soochow University-Cardiology
      • Xuzhou, Jiangsu, Cina, 221002
        • The Affiliated Hospital of Xuzhou Medical University
      • Xuzhou, Jiangsu, Cina, 221002
        • The Affiliated Hospital of Xuzhou Medical University-Cardiology
      • Zhenjiang, Jiangsu, Cina, 212001
        • The Affiliated Hospital of Jiangsu University
      • Zhenjiang, Jiangsu, Cina, 212001
        • The Affiliated Hospital of Jiangsu University-Nephrology
    • Jiangxi
      • Nanchang, Jiangxi, Cina, 330006
        • The First Affiliated Hospital of NanChang University
      • Nanchang, Jiangxi, Cina, 330006
        • Jiangxi Provincial People's Hospital-Cardiology
      • Nanchang, Jiangxi, Cina, 330006
        • The First Affiliated Hospital of Nanchang University-Nephrology
    • Jilin
      • Changchun, Jilin, Cina, 130033
        • China-Japan Union Hospital of Jilin University
      • Changchun, Jilin, Cina, 130033
        • China-Japan Union Hospital of Jilin University-Cardiology
      • Changchun, Jilin, Cina, 130033
        • The Second Hospital of Jilin University-Nephrology
      • Changchun, Jilin, Cina, 130033
        • The Second Hospital of Jilin University_Changchun
    • Liaoning
      • Dalian, Liaoning, Cina, 116011
        • The First Affiliated Hospital of Dalian Medical University
      • Dalian, Liaoning, Cina, 116011
        • The First Affiliated Hospital of Dalian Medical University-Nephrology
      • Dalian, Liaoning, Cina, 116033
        • Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Cardiology
      • Dalian, Liaoning, Cina, 116033
        • Central Hospital of Dalian University of Technology (Dalian Municipal Central Hospital) -Nephrology
      • Jinzhou, Liaoning, Cina, 121012
        • The First Affiliated Hospital of Jinzhou Medical University-Cardiology
      • Shenyang, Liaoning, Cina, 110136
        • Shengjing Hospital of China Medical University-Cardiology
    • Shaanxi
      • Xi'an, Shaanxi, Cina, 710061
        • The First Affiliated Hospital of Xi'an JiaoTong University-Cardiovascular
    • Shandong
      • Jinan, Shandong, Cina, 250033
        • The Second Hospital of Shandong University
      • Jinan, Shandong, Cina, 250013
        • The First Affiliated Hospital of Shandong First Medical University (Shandong Provincial Qianfoshan Hospital)-Cardiology
      • Jinan, Shandong, Cina, 250013
        • Jinan Central Hospital-Cardiovascular
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, Cina, 200040
        • Huashan Hospital Fudan University
      • Shanghai, Shanghai Municipality, Cina, 200080
        • Shanghai General Hospital-Cardiology
      • Shanghai, Shanghai Municipality, Cina, 200092
        • Xinhua Hospital Affiliated to Shanghai Jiao Tong University-Nephrology
      • Shanghai, Shanghai Municipality, Cina, 200233
        • Shanghai Sixth People's Hospital Affiliated to Shanghai JiaoTong University-Nephrology
      • Shanghai, Shanghai Municipality, Cina, 201199
        • Central Hospital of Minhang District, Shanghai-Nephrology
    • Shanxi
      • Linfen, Shanxi, Cina, 041099
        • Linfen Central Hospital-Cardiology
    • Sichuan
      • Chengdu, Sichuan, Cina, 610071
        • Sichuan Provincial People's Hospital- Nephrology
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, Cina, 300140
        • Tianjin 4th Center Hospital
      • Tianjin, Tianjin Municipality, Cina, 300122
        • Tianjin People's Hospital
    • Yunnan
      • Kunming, Yunnan, Cina, 650033
        • The Second Affiliated Hospital of Kunming Medical University
    • Zhejiang
      • Hangzhou, Zhejiang, Cina, 310014
        • Zhejiang Provincial People's Hospital
      • Hangzhou, Zhejiang, Cina, 310014
        • Zhejiang Provincial People's Hospital-Cardiology Department
      • Hangzhou, Zhejiang, Cina, 310003
        • The First Affiliated Hospital, Zhejiang University School of Medicine-Cardiology
  • Corea del Sud
      • Busan, Corea del Sud, 49201
        • Dong-A University Hospital
      • Busan, Corea del Sud, 49241
        • Pusan National University Hospital
      • Busan, Corea del Sud, 49201
        • Dong-A University Medical Center
      • Daegu, Corea del Sud, 42601
        • Keimyung University Dongsan Hospital
      • Daegu, Corea del Sud, 42601
        • Keimyung University Dongsan Medical Center
      • Daegu, Corea del Sud, 42472
        • Daegu Catholic Univ. Medical Center
      • Daejeon, Corea del Sud, 35015
        • Chungnam National University Hospital
      • Gangwon-do, Corea del Sud, 26426
        • WonJu Severance Christian Hospital
      • Goyang, Corea del Sud, 410-719
        • National Health Insurance Corporation Ilsan Hospital
      • Gwangju, Corea del Sud, 61469
        • Chonnam National University Hospital
      • Gyeonggi-do, Corea del Sud, 471-101
        • Hanyang University Guri Hospital
      • Gyeonggi-do, Corea del Sud, 14068
        • Hallym UMC_Pyeongchon
      • Incheon, Corea del Sud, 21565
        • Gachon University Gil Medical Center
      • Seoul, Corea del Sud, 03080
        • Seoul National University Hospital
      • Seoul, Corea del Sud, 01830
        • Nowon Eulji Medical Center, Eulji University
      • Seoul, Corea del Sud, 03722
        • Severance Hospital, Yonsei University Health System
      • Seoul, Corea del Sud, 05278
        • Kyung Hee University Hospital at Gangdong
      • Seoul, Corea del Sud, 06591
        • The Catholic University of Korea, Seoul St. Mary's Hospital
      • Seoul, Corea del Sud, 02841
        • Korea University Anam Hospital
      • Seoul, Corea del Sud, 08308
        • Korea University Guro Hospital
      • Seoul, Corea del Sud, 05030
        • Konkuk University Medical Center
      • Seoul, Corea del Sud, 02447
        • Kyunghee University Medical Center
      • Seoul, Corea del Sud, 06591
        • Seoul Saint Mary's Hospital
      • Seoul, Corea del Sud, 07441
        • KangNam Sacred Heart Hospital
    • Gyeonggi-do
      • Goyang-si, Gyeonggi-do, Corea del Sud, 10444
        • National Health Insurance Corporation Ilsan Hospital
      • Seongnam-si, Gyeonggi-do, Corea del Sud, 13620
        • Seoul National University Bundang Hospital
  • Croazia
      • Rijeka, Croazia, 51000
        • KBC Rijeka, Zavod za kardiomiopatije
      • Rijeka, Croazia, 51000
        • Clinical Hospital Centre Rijeka_Cardiology
      • Rijeka, Croazia, 51000
        • Clinical Hospital Centre Rijeka_Nefrology
      • Split, Croazia, 21000
        • KBC Split / Krizine/ Kardiologija
      • Zagreb, Croazia, 10000
        • KBC Zagreb_Cardiology
      • Zagreb, Croazia, 10000
        • KBC Zagreb_Nefrology
    • City of Zagreb
      • Zagreb, City of Zagreb, Croazia, 10000
        • Poliklinika Solmed
      • Zagreb, City of Zagreb, Croazia, 10000
        • KB Dubrava, Zavod za bolesti srca i krvnih zila
    • Krapinsko Zagorska County
      • Krapinske Toplice, Krapinsko Zagorska County, Croazia, 49217
        • Specijalna bolnica za medicinsku rehabilitaciju Krapinske Toplice_Cardiology
  • Danimarca
      • Aarhus N, Danimarca, 8200
        • Aarhus Universitetshospital, Hjertesygdomme
      • Gistrup, Danimarca, 9260
        • Aalborg Universitetshospital Hjertemedicinsk Afdeling
      • Herning, Danimarca, 7400
        • Regionshospitalet Gødstrup, Hjertesygdomme
      • Hvidovre, Danimarca, 2650
        • Hvidovre Hospital Hjertemedicinsk
      • Kolding, Danimarca, 6000
        • Kolding Sygehus Karkirurgi
      • Roskilde, Danimarca, 4000
        • Sjællands Universitetshospital, Roskilde - Kardiologisk Afdeling
      • Svendborg, Danimarca, 5700
        • Svendborg Sygehus - Kardiologisk
      • Viborg, Danimarca, 8800
        • Viborg Sygehus
    • Region Sjælland
      • Holbæk, Region Sjælland, Danimarca, 4300
        • Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4
  • Germania
      • Aachen, Germania, 52074
        • Universitaetsklinikum Aachen AöR
      • Aachen, Germania, 52074
        • Uniklinik Aachen - Med. Klinik I
      • Bad Homburg, Germania, 61348
        • Kardiologische Praxis, Bad Homburg
      • Berlin, Germania, 12203
        • Charité - Campus Benjamin Franklin - Klinik für Nephrologie und Internistische Intensivmedizin
      • Dessau, Germania, 06846
        • Praxis Dr.med. Frank Menzel
      • Dresden, Germania, 01307
        • Herzzentrum Dresden GmbH Universitaetsklinik
      • Dresden, Germania, 01277
        • Kreutzmann
      • Dresden, Germania, 01307
        • Uniklinik TU Dresden - Herzzentrum Dresden GmbH
      • Dresden, Germania, 01277
        • Cardiologicum Dresden und Pirna - MVZ "Am Felsenkeller" (Dresden)
      • Dresden, Germania, 01099
        • Facharztzentrum Dresden Betriebsgesellschaft mbH
      • Düsseldorf, Germania, 40210
        • DaVita Clinical Research Deutschland GmbH
      • Elsterwerda, Germania, 04910
        • Zentrum fuer Klinische Studien Suedbrandenburg GmbH
      • Essen, Germania, 45136
        • InnoDiab Forschung GmbH
      • Falkensee, Germania, 14612
        • Zentrum für klinische Forschung, Dr. med. Lüdemann
      • Frankfurt, Germania, 60389
        • MVZ CCB Frankfurt und Main-Taunus GbR
      • Frankfurt, Germania, 60590
        • Nephrologie Universitätsklinikum Frankfurt
      • Frankfurt, Germania, 60596
        • Studienzentrum ClinPhenomics
      • Frankfurt, Germania, 60590
        • Uniklinik FFM - Nephrologie
      • Freiburg im Breisgau, Germania, 79100
        • Nierenzentrum Freiburg
      • Halle, Germania, 06120
        • Universitätsklinikum Halle - Innere Medizin II
      • Heidelberg, Germania, 69115
        • St. Josefskrankenhaus Heidelberg - Diabeteszentrum
      • Homburg, Germania, 66421
        • Universität des Saarlandes - Innere Med. III
      • Homburg Saar, Germania, 66421
        • Universität des Saarlandes - Innere Med. IV
      • Jena, Germania, 07747
        • University Hospital Jena KöR
      • Jena, Germania, 07747
        • Uniklinik Jena - Kardiologie
      • Lübeck, Germania, 23538
        • Uniklinik Schleswig-Holstein - Medizinischen Klinik I am Campus Lübeck
      • Mainz, Germania, 55131
        • Marienhaus Klinikum Mainz GmbH - Innere Medizin I
      • Mainz, Germania, 55131
        • Universitätsmedizin der JGU Mainz - Kardiologie I
      • Mannheim, Germania, 68165
        • zero PRAXEN Mannheim-Schwetzingerstadt
      • Reichelsheim, Germania, 61203
        • Praxis Reichelsheim
      • Witten, Germania, 58455
        • Kahrmann
      • Witten, Germania, 58455
        • Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
    • Baden-Wurttemberg
      • Freiburg im Breisgau, Baden-Wurttemberg, Germania, 79106
        • Universitätsklinikum Freiburg - Medical Center
      • Karlsbad, Baden-Wurttemberg, Germania, 76307
        • SRH Klinikum Karlsbad-Langensteinbach GmbH - Innere Medizin
    • Holstein
      • Oldenburg in Holstein, Holstein, Germania, 23758
        • RED-Institut für medizinische Forschung und Fortbildung GmbH
    • Thuringia
      • Coburg, Thuringia, Germania, 96450
        • Sana Kliniken Oberfranken Coburg GmbH - II. Med. Klinik, Kardiologie
  • Giappone
      • Bunkyo-ku, Tokyo, Giappone, 113-8655
        • The Univ. of Tokyo Hp., Dept. of Cardiovascular Medicine
      • Bunkyo-ku, Tokyo, Giappone, 113-8603
        • NIPPON MEDICAL SCHOOL HOSPITAL_Cardiovascular medicine
      • Chiba-shi, Chiba, Giappone, 260-0804
        • Akaicho Clinic
      • Chikushino-shi, Fukuoka, Giappone, 818-8516
        • Fukuokaken Saiseikai Futsukaichi Hospital_Cardiovascular Medicine
      • Chuo-city, Yamanashi, Giappone, 409-3898
        • University of Yamanashi Hospital_Cardiology
      • Fukuoka, Giappone, 810-8563
        • National Hospital Organization Kyushu Medical Center_Nephrology
      • Fukuoka-shi, Fukuoka, Giappone, 814-0133
        • Fukuoka University Hospital_Cardiology
      • Fukuoka-shi, Fukuoka, Giappone, 810-0001
        • Saiseikai Fukuoka General Hospital
      • Hamada-shi, Shimane, Giappone, 697-8511
        • National Hospital Organization Hamada Medical Center_Cardiology
      • Hamamatsu-shi, Shizuoka, Giappone, 430-0929
        • JA Shizuoka Kohseiren Enshu Hospital_ cardiology
      • Ibaraki, Giappone, 311-0113
        • Naka Kinen Clinic
      • Ibaraki, Giappone, 311-3193
        • National Hospital Organization Mito Medical Center_Cardiovascular medicine
      • Ibaraki, Giappone, 311-0113
        • Naka Kinen Clinic_Internal medicine
      • Ibaraki, Giappone, 331-0133
        • Nishiyamado Keiwa Hospital_Internal Medicine
      • Ibaraki, Giappone, 331-0133
        • Nishiyamado Keiwa Hospital
      • Kishiwada, Osaka, Giappone, 596-0042
        • Kishiwada Tokushukai Hospital_Cardiology
      • Kita-azumi-gun, Nagano, Giappone, 399-8695
        • North Alps Medical Center Azumi Hospital_Cardiology
      • Kitakyushu-shi, Fukuoka, Giappone, 805-8508
        • Steel Memorial Yawata Hospital_Cardiology
      • Kitakyushu-shi,Fukuoka, Giappone, 802-8555
        • Kokura Memorial Hospital_Cardiology
      • Koga-shi, Fukuoka, Giappone, 811-3195
        • National Hospital Organization Fukuokahigashi Medical Center
      • Koga-shi, Fukuoka, Giappone, 811-3195
        • National Hospital Organization Fukuokahigashi Medical Center_Nephrology
      • Kumamoto-shi, Kumamoto, Giappone, 860-8556
        • Kumamoto University Hospital, Cardiovascular Medicine
      • Kure-shi, Hiroshima, Giappone, 737-0023
        • NHO Kure Medical Center and Chugoku Cancer Center_Cardiology
      • Kusegun, Kyoto, Giappone, 613-0034
        • Kyoto Okamoto Memorial Hospital
      • Kusegun, Kyoto, Giappone, 613-0034
        • Kyoto Okamoto Memorial Hospital_Cardiology
      • Kyoto-shi, Kyoto, Giappone, 612-8555
        • National Hospital Organization Kyoto Medical Center_Cardiology
      • Kyoto-shi, Kyoto, Giappone, 607-8062
        • Rakuwakai Otowa Hospital
      • Kyoto-shi, Kyoto, Giappone, 607-8062
        • Rakuwakai Otowa Hospital_Cardiology
      • Kyoto-shi,Kyoto, Giappone, 601-1495
        • Ijinkai Takeda General Hospital, Cardiovascular Medicine
      • Maebashi-shi, Gunma, Giappone, 371-0811
        • Maebashi Red Cross Hospital
      • Maebashi-shi, Gunma, Giappone, 371-0811
        • Maebashi Red Cross Hospital_Cardiology
      • Matsubara-shi, Osaka, Giappone, 580-0032
        • Matsubara Tokushukai Hospital_Neurosurgery
      • Matsudo-shi, Giappone, 270-2251
        • Chiba-Nishi General Hospital, Cardiology
      • Matsumoto-shi, Nagano, Giappone, 390-8621
        • Shinshu University Hospital_Matsumoto-shi, Nagano
      • Matsumoto-shi, Nagano, Giappone, 390-8621
        • Shinshu University Hospital__Department of Cardiology
      • Meguro-ku, Tokyo, Giappone, 153-0051
        • Mishuku Hospital_Cardiology
      • Minato-ku, Tokyo, Giappone, 108-0073
        • Tokyo Saiseikai Central Hospital
      • Miura-gun, Kanagawa, Giappone, 240-0116
        • Hayama Heart Center
      • Miura-gun, Kanagawa, Giappone, 240-0116
        • Hayama Heart Center_Cardiology
      • Miyakonojo-shi, Miyazaki, Giappone, 885-0002
        • Miyakonojo Medical Association Hospital
      • Miyakonojo-shi, Miyazaki, Giappone, 885-0002
        • Miyakonojo Medical Association Hospital_Cardiology
      • Morioka-shi, Iwate, Giappone, 020-0066
        • Iwate Prefectural Central Hospital
      • Morioka-shi, Iwate, Giappone, 020-0066
        • Iwate Prefectural Central Hospital_Cardiology
      • Nagoya-shi, Aichi, Giappone, 457-0818
        • Social Medical Corporation Kojunkai Daido Clinic
      • Nagoya-shi, Aichi, Giappone, 466-8560
        • Nagoya University Hospital_Cardiology
      • Naha-shi, Okinawa, Giappone, 902-8511
        • Naha City Hospital
      • Naha-shi, Okinawa, Giappone, 902-8511
        • Naha City Hospital_Cardiovascular Medicine
      • Nara-shi, Nara, Giappone, 630-8581
        • Nara Prefecture General Medical Center
      • Nara-shi, Nara, Giappone, 630-8581
        • Nara Prefecture General Medical Center_Nephrology
      • Nishinomiya-shi, Hyogo, Giappone, 662-0918
        • Hyogo Prefectual Nishinomiya Hospital_Nephrology
      • Oita-shi, Oita, Giappone, 870-0263
        • Oita Medical Center_Cardiology
      • Okayama, Giappone, 701-0192
        • Kawasaki Medical School Hospital_Nephrology
      • Omihachiman-shi, Siga, Giappone, 523-0082
        • Omihachiman Community Medical Center_Omihachiman-shi, Siga
      • Omihachiman-shi, Siga, Giappone, 523-0082
        • Omihachiman Community Medical Center_Cardiovascular Medicine
      • Osaka, Giappone, 569-1045
        • Takatsuki Red Cross Hospital
      • Osaka, Giappone, 564-0013
        • Saiseikai Suita Hospital_Cardiovascular Medicine
      • Osaka, Giappone, 569-1045
        • Takatsuki Red Cross Hospital_Diabetes and Endocrine Div.
      • Osaka, Giappone, 581-0011
        • Yao Tokushukai General Hospital_Cardiovascular division
      • Osaka-city, Osaka, Giappone, 530-0005
        • Sakurabashi Watanabe Advanced Healthcare Hospital
      • Osaka-shi, Osaka, Giappone, 538-0044
        • Kitada Clinic
      • Osaka-shi, Osaka, Giappone, 533-0024
        • Yodogawa Christian Hospital_Cardiovascular medicine
      • Osaka-shi, Osaka, Giappone, 534-0021
        • Osaka City General Hospital_Cardiology
      • Osaka-shi,Osaka, Giappone, 559-0012
        • Social Corporation Keigakukai Minami Osaka Hospital_Cardiology
      • Ota-shi, Gunma, Giappone, 373-8585
        • Ota Memorial Hospital
      • Ota-shi, Gunma, Giappone, 373-8585
        • Ota Memorial Hospital_Cardiology
      • Sagamihara-shi, Kanagawa, Giappone, 252-0375
        • Kitasato University Hospital_Sagamihara-shi, Kanagawa
      • Sagamihara-shi, Kanagawa, Giappone, 252-0392
        • National Hospital Organization Sagamihara National Hospital
      • Sagamihara-shi, Kanagawa, Giappone, 252-0375
        • Kitasato University Hospital_Cardiovascular Medicine
      • Sagamihara-shi, Kanagawa, Giappone, 252-0392
        • National Hospital Organization Sagamihara National Hospital_Cardiology
      • Saitama-shi, Saitama, Giappone, 338-0837
        • Sanai Hospital
      • Saitama-shi, Saitama, Giappone, 338-0837
        • Sanai Hospital_Cardiology
      • Sapporo-shi, Hokkaido, Giappone, 062-0003
        • Hanaoka Seishu Memorial Hosp._Cardiovascular Medicine
      • Sendai-shi, Miyagi, Giappone, 983-0039
        • Shinden Higashi Clinic
      • Sendai-shi, Miyagi, Giappone, 980-8574
        • Tohoku University Hospital, Cardiovascular
      • Sendai-shi, Miyagi, Giappone, 981-3133
        • Sendai Cardiovascular Center_Cardiology
      • Sendai-shi, Miyagi, Giappone, 983-0039
        • Shinden Higashi Clinic_Internal medicine
      • Shizuoka, Giappone, 430-0929
        • JA Shizuoka Kohseiren Enshu Hospital_Internal Medicine
      • Suita-shi, Osaka, Giappone, 564-0013
        • Saiseikai Suita Hospital_Suita-shi, Osaka
      • Suita-shi, Osaka, Giappone, 565-0862
        • Osaka Saiseikai Senri Hospital
      • Suita-shi, Osaka, Giappone, 565-0862
        • Osaka Saiseikai Senri Hospital_Cardiology
      • Tachikawa-shi, Tokyo, Giappone, 190-0014
        • National Hospital Organization Disaster Medical Center_Nephrology
      • Takamatsu-shi, Kagawa, Giappone, 760-0017
        • Takamatsu Red Cross Hospital_Cardiovascular Medicine
      • Takamatsu-shi, Kagawa, Giappone, 760-8557
        • Kagawa Prefectural Central Hospital_Cardiovascular Medicine
      • Tokyo, Giappone, 192-0918
        • Minamino Cardiovascular Hospital_Cardiovascular medicine
      • Tondabayashi-shi, Osaka, Giappone, 584-0082
        • Saiseikai tondabayashi Hospital_Cardiology
      • Tsukuba-shi, Ibaraki, Giappone, 305-8558
        • Tsukuba Medical Center Hospital_Department of Cardiology
      • Wakayama, Giappone, 640-8558
        • Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology
      • Wako-shi, Saitama, Giappone, 351-0102
        • National Hospital Organization Saitama Hospital
      • Wako-shi, Saitama, Giappone, 351-0102
        • National Hospital Organization Saitama Hospital_Cardiology
      • Yokohama-shi, Kanagawa, Giappone, 234-0054
        • Saiseikai Yokohamashi Nanbu Hospital_Cardiology
      • Yokohama-shi, Kanagawa, Giappone, 236-0004
        • Yokohama City University Hospital
      • Yonezawa-shi, Yamagata, Giappone, 992-0033
        • Sanyudo Hospital
      • Yonezawa-shi, Yamagata, Giappone, 992-0033
        • Sanyudo Hospital_Cardiology
    • Ehime
      • Uwajima-shi, Ehime, Giappone, 798-8510
        • Uwajima City Hospital_ Cardiology
      • Uwajima-shi, Ehime, Giappone, 798-8510
        • Uwajima City Hospital_Cardiology
    • Fukushima, Japan
      • Koriyama-shi, Fukushima, Japan, Giappone, 963-8851
        • Seino Internal Medicine Clinic
      • Koriyama-shi, Fukushima, Fukushima, Japan, Giappone, 963-8851
        • Seino Internal Medicine Clinic_Internal medicine
    • Kumamoto, Japan
      • Kumamoto, Kumamoto, Japan, Giappone, 862-0976
        • Jinnouchi Hospital_Internal Medicine
    • Miyazaki
      • Miyazaki, Miyazaki, Giappone, 880-2102
        • Miyazaki Medical Association Hospital_Cardiology
  • Grecia
      • Alexandroupoli, Grecia, 68100
        • Alexandroupoli University General Hospital
      • Athens, Grecia, 11527
        • "Laiko" General Hospital of Athens
      • Athens, Grecia, 11528
        • Alexandra General Hospital, Therapeutic Clinic
      • Athens, Grecia, 11527
        • Hippokration Hospital
      • Athens, Grecia, GR-17562
        • Iatriko Athinon 'Palaiou Falirou'
      • Athens, Grecia, GR-14233
        • Konstantopouleio G.H. of Athens, "Agia Olga"
      • Athens, Grecia, GR-15123
        • "Hygeia" General Hospital of Athens
      • Athens, Grecia, 15125
        • Iatriko Athinon (Athens Medical Canter)
      • Athens, Grecia, 17562
        • Iatriko Athinon 'Palaiou Falirou'
      • Athens, Grecia, 14233
        • Konstantopouleio G.H. of Athens, "Agia Olga"
      • Athens, Grecia, 15123
        • "Hygeia" General Hospital of Athens
      • Athens, Grecia, 11527
        • Thoracic General Hospital Of Athens I Sotiria - Cardiology Department
      • Chios, Grecia, GR82100
        • General Hospital of Chios "Skilitsio"
      • Chios, Grecia, 82100
        • General Hospital of Chios "Skilitsio" - Cardiology Clinic
      • Heraklion, Grecia, 71500
        • University General Hospital of Heraklion
      • Heraklion, Grecia, 71500
        • Periphery University Hospital of Heraklion
      • Ioannina, Grecia, 45500
        • University General Hospital of Ioannina,Internal Medicine
      • Kifissia, Grecia, GR-14561
        • KAT General Hospital of Attica
      • Kifissia, Grecia, 14561
        • Kat Attica General Hospital - Cardiology Department
      • Lamia, Grecia, 35100
        • General Hospital of Lamia
      • Larissa, Grecia, GR-41110
        • Univ Gen Hospital Larisa, Cardiology Medicine Clinic
      • Larissa, Grecia, 41110
        • Univ Gen Hospital Larisa, Cardiology Medicine Clinic
      • Pylea, Thessaloniki, Grecia, 57001
        • Iatriko Athinon (Athens Medical Canter)
      • Rio, Patra, Grecia, 26504
        • General University Hospital of Patras,Nephrology clinic
      • Thessaloniki, Grecia, 54636
        • "AHEPA" University General Hospital of Thessaloniki
      • Thessaloniki, Grecia, 54642
        • General Hospital of Thessaloniki "Ippokrateio"
      • Thessaloniki, Grecia, GR-57001
        • "Thermi" Private Hosital
      • Thessaloniki, Grecia, 54636
        • "AHEPA" University Hospital of Thessaloniki
      • Thessaloniki, Grecia, 57001
        • "Thermi" Private Hosital
      • Thessaloniki, Grecia, 54642
        • General Hospital of Thessaloniki 'Ippokrateio' Dialysis Unit
      • Thessaloniki, Grecia, 57010
        • Gen Hospital of Thessaloniki G.Papanikolaou,Cardiology Dpt
      • Thessaloniki, Grecia, 57001
        • Iatriko Athinon (Athens Medical Canter)
      • Thessaloniki, Grecia, 55134
        • General Hospital of Thessaloniki 'Agios Pavlos' - Nephrology Clinic
    • Attica
      • Athens, Attica, Grecia, 12462
        • University Hospital of Athens ATTIKON
      • Haidari-Athens, Attica, Grecia, GR-12462
        • University Hospital of Athens ATTIKON
  • India
      • Chandigarh, India, 160012
        • Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
      • Jaipur, India, 302017
        • Eternal Heart Care Centre
      • New Delhi, India, 110060
        • Sir Ganga Ram Hospital
      • New Delhi, India, 110002
        • G B Pant Institute of Postgraduate Medical Education and Res
      • New Delhi, India, 110017
        • Max Super Speciality Hospital_New Delhi
      • New Delhi, India, 110002
        • Lok Nayak Hospital
      • New Delhi, India, 110017
        • Max Super Speciality Hospital, Saket
      • New Delhi, India, 110025
        • Fortis Escort Health Institute
      • Palakkad, India, 678013
        • Lakshmi Hospital
    • Andhra Pradesh
      • Guntur, Andhra Pradesh, India, 522001
        • Vedanta Hospitals
      • Guntur, Andhra Pradesh, India, 522001
        • Lalitha PVS Institute of Medical Sciences
      • Hyderabad, Andhra Pradesh, India, 500082
        • Nizam's Institute of Medical Sciences
      • Vijayawada, Andhra Pradesh, India, 520002
        • Sunrise Hospital
    • Gujarat
      • Ahmedabad, Gujarat, India, 380059
        • Apollo CHSF Heart Institute
      • Surat, Gujarat, India, 395009
        • BAPS Pramukh Swami Hospital
      • Surat, Gujarat, India, 395001
        • Shri B. D. Mehta Mahavir Heart Institute
      • Surat, Gujarat, India, 395001
        • Unicare heart institute and research centre
    • Karnataka
      • Bangalore, Karnataka, India, 560092
        • Lifecare Hospital and Research Centre
      • Bangalore, Karnataka, India, 560017
        • Manipal Hospital, Old Airport Road, Bengaluru
      • Bengaluru, Karnataka, India, 560069
        • Sri Jayadeva Institute of Cardiovascular Sciences & Research
      • Mangalore, Karnataka, India, 575002
        • Omega Hospital (P) Limited
      • Manipal, Karnataka, India, 576104
        • Kasturba Medical College and Hospital
      • Manipal, Karnataka, India, 576104
        • Kasturba Medical College and Hospital, Manipal
    • Karnatka
      • Belagavi, Karnatka, India, 590010
        • KLES & Prabhakar Kore Hospital and Research Centre
    • Kerala
      • Kochi, Kerala, India, 682018
        • Lisie Hospital
      • Kozhikode, Kerala, India, 673008
        • Calicut Medical College
      • Trivandrum, Kerala, India, 695011
        • Government Medical College Trivandrum
    • Maharashtra
      • Aurangabad, Maharashtra, India, 431010
        • Kamalnayan Bajaj Hospital
      • Aurangabad, Maharashtra, India, 431005
        • Kamalnayan Bajaj Hospital
      • Mumbai, Maharashtra, India, 400012
        • Seth GS medical college and KEM Hospital
      • Nagpur, Maharashtra, India, 440012
        • Shri Krishna Hrudayalaya & Critical Care Centre
      • Nagpur, Maharashtra, India, 440010
        • Arneja Heart & Multispeciality Hospital
      • Nagpur, Maharashtra, India, 440009
        • Government Medical College and Super Speciality Hospital, Nagpur
      • Nashik, Maharashtra, India, 422005
        • Vijan Hospital & Research Centre
      • Nashik, Maharashtra, India, 422005
        • Chopda Medicare and Research Centre Pvt. Ltd.
      • Pune, Maharashtra, India, 411001
        • Grant Medical Foundation
      • Pune, Maharashtra, India, 411001
        • B J Goverment Medical College and Sassoon General Hospital
    • National Capital Territory of Delhi
      • New Delhi, National Capital Territory of Delhi, India, 110002
        • G B Pant Institute of Postgraduate Medical Education and Research
      • New Delhi, National Capital Territory of Delhi, India, 110062
        • Batra Hospital and Medical Research Center
      • New Delhi, National Capital Territory of Delhi, India, 110025
        • Fortis Escorts Heart Institute, New Delhi
    • New Delhi
      • New Dehli, New Delhi, India, 110029
        • VMMC & Safdarjung Hospital
    • Punjab
      • Ludhiana, Punjab, India, 141001
        • Dayanand Medical College & Hospital
    • Tamil Nadu
      • Chennai, Tamil Nadu, India, 600006
        • Apollo Hospitals Education & Research Foundation
    • Telangana
      • Hyderabad, Telangana, India, 500012
        • Osmania General Hospital
      • Hyderabad, Telangana, India, 500020
        • Guru Nanak CARE Hospitals
      • Hyderabad, Telangana, India, 500012
        • Osmania General Hospital_Hyderabad
      • Hyderabad, Telangana, India, 500033
        • Apollo Hospital Jubilee Hills, Hyderabad
      • Hyderbad, Telangana, India, 500 012
        • Osmania General Hospital
    • Uttar Pradesh
      • Lucknow, Uttar Pradesh, India, 226030
        • Medanta Lucknow Hospital
      • Lucknow, Uttar Pradesh, India, 226003
        • Gandhi Memorial Hospital- King George's Medical University
  • Israele
      • Holon, Israele, 58100
        • Wolfson MC - Diabetes Clinic
      • Jerusalem, Israele, 91120
        • Hadassah Ein Karam MC - Cardio Department
      • Nahariya, Israele, 22100
        • Western Galilee MC - Cardiology Department
      • Petah Tikva, Israele, 49100
        • Rabin MC Beilinson - Heart Failure Unit
      • Rehovot, Israele, 7661041
        • Kaplan MC - Nephrology unit
      • Tel Aviv, Israele, 6423906
        • Sourasky MC - Cardio Vascular Research Center
      • Tel Litwinsky, Israele, 5265601
        • Sheba MC - Cardiology Clinical Research Unit
  • Italia
      • Arzignano (VI), Italia, 36071
        • West Vicenza General Hospital
      • Bologna, Italia, 40138
        • Policlinico S. Orsola - Malpighi
      • Catania, Italia, 95126
        • AO Cannizzaro
      • Chieti Scalo, Italia, 66100
        • Università degli studi G. D'Annunzio Chieti Pescara - CAST
      • Florence, Italia, 50134
        • AOU Careggi Firenze
      • Genova, Italia, 16132
        • IRCCS Ospedale Policlinico San Martino
      • Genova, Italia, 16132
        • IRCCS Azienda Ospedaliero Universitaria San Martino - IST
      • Milan, Italia, 20138
        • Centro Cardiologico Monzino
      • Milan, Italia, 20132
        • Ospedale San Raffaele S.r.l. - Unità Clinica Riabilitazione Specialistica Cardiologica
      • Montichiari, Italia, 25018
        • ASST degli Spedali Civili di Brescia-Presidio Ospedaliero di Montichiari
      • Naples, Italia, 80131
        • Azienda Ospedaliera Universitaria Federico II Di Napoli
      • Palermo, Italia, 90127
        • AOUP Giaccone Palermo
      • Palermo, Italia, 90127
        • ARNAS Ospedali Civico Di Cristina Benfratelli - Presidio Ospedaliero "Civio e Benfratelli"
      • Pavia, Italia, 27100
        • Fondazione IRCCS Policlinico San Matteo
      • Pisa, Italia, 56124
        • AOU Pisana Cisanello
      • Roma, Italia, 00133
        • Policlinico Tor Vergata
      • Roma, Italia, 00168
        • Policlinico A. Gemelli IRCCS
      • Rome, Italia, 00189
        • AOU S. Andrea
      • Trieste, Italia, 34128
        • Azienda Sanitaria Univ Giuliano Isontina - SC Cardiologia
      • Verona, Italia, 37126
        • AOUI Verona
    • Cz
      • Catanzaro, Cz, Italia, 88100
        • Azienda Ospedaliero-Universitaria Renato Dulbecco
    • Fe
      • Cona (Ferrara), Fe, Italia, 44124
        • A.O.U. Ferrara, Sant'Anna
    • Lombardy
      • Bergamo, Lombardy, Italia, 24127
        • Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII
    • RM
      • Roma, RM, Italia, 00161
        • Policlinico Umberto I Seconda Clinica Medica
  • Lettonia
      • Daugavpils, Lettonia, 5417
        • Daugavpils Regional Hospital
      • Daugavpils, Lettonia, 5401
        • Ari Med
      • Jelgava, Lettonia, 3001
        • Zemgales diabetes centre
      • Riga, Lettonia, 1002
        • P. Stradins Clinical University Hospital
      • Riga, Lettonia, 1011
        • Adoria
      • Riga, Lettonia, 1079
        • Riga East Clinical University Hospital - Clinic "Gailezers"
  • Lituania
      • Alytus, Lituania, 63200
        • Klinikiniai sprendimai, Alytus
      • Alytus, Lituania, LT-63200
        • Klinikiniai sprendimai, Alytus
      • Kaunas, Lituania, 50161
        • Hospital of Lithuanian University of Health Sciences Kauno klinikos
      • Kaunas, Lituania, 48259
        • Kaunas City Polyclinic, Silainiu department
      • Kaunas, Lituania, 49387
        • Klinikiniai sprendimai, Kaunas
      • Kaunas, Lituania, 49449
        • JSC "Saules seimos medicinos centras"
      • Kaunas, Lituania, LT-49387
        • Klinikiniai sprendimai, Kaunas
      • Kaunas, Lituania, LT-51270
        • Kaunas City polyclinic Dainava Branch
      • Kaunas, Lituania, 47144
        • Lithuanian university of health sciences Clinical hospital
      • Kaunas, Lituania, 51270
        • Kaunas City polyclinic Dainava Branch
      • Klaipėda, Lituania, 92288
        • Klaipeda University Hospital
      • Klaipėda, Lituania, LT-92288
        • Klaipeda University Hospital
      • Panevezys, Lituania, 35144
        • Republican Panevezys Hospital
      • Panevezys, Lituania, LT-35144
        • Republican Panevezys Hospital
      • Vilnius, Lituania, 08406
        • JSC Inlita Santaros
      • Vilnius, Lituania, 04130
        • JSC Inlita Lazdynai CMC
      • Šiauliai, Lituania, LT-76206
        • Pirmoji Viltis
  • Malaysia
      • Ipoh, Perak, Malaysia, 30450
        • Hospital Raja Permaisuri Bainun Ipoh
      • Kuala Lumpur, Malaysia, 50400
        • National Heart Institute
      • Pulau Pinang, Malaysia, 13700
        • Hospital Seberang Jaya
      • Sabak Bernam, Malaysia, 88300
        • Hospital Queen Elizabeth II
      • Seremban, Malaysia, 70300
        • Hospital Tuanku Jaafar
    • Kedah
      • Alor Star, Kedah, Malaysia, 05460
        • Hospital Sultanah Bahiyah
      • Sungai Petani, Kedah, Malaysia, 08000
        • Hospital Sultan Abdul Halim
    • Kelantan
      • Kota Bharu, Kelantan, Malaysia, 15586
        • Hospital Raja Perempuan Zainab Ii
      • Kota Bharu, Kelantan, Malaysia, 16150
        • Hospital Universiti Sains Malaysia_Kota Bharu, Kelantan
    • Kuala Lumpur
      • Cheras, Kuala Lumpur, Malaysia, 56000
        • Hospital Canselor Tuanku Muhriz UKM
      • Lembah Pantai, Kuala Lumpur, Malaysia, 59100
        • University Malaya Medical Centre
    • Perak
      • Ipoh, Perak, Malaysia, 30450
        • Hospital Raja Permaisuri Bainun Ipoh
      • Seri Manjung, Perak, Malaysia, 32040
        • Hospital Seri Manjung
    • Sarawak
      • Kota Samarahan, Sarawak, Malaysia, 94300
        • Sarawak Heart Centre
      • Miri, Sarawak, Malaysia, 98000
        • Hospital Miri
    • Selangor
      • Sungai Buloh, Selangor, Malaysia, 47000
        • University Technology MARA (UiTM) - Sg Buloh
  • Messico
      • Aguascalientes, Messico, 20230
        • Centro de Investigación Cardiometabólica de Aguascalientes
      • Querétaro, Messico, 76000
        • Centro de Estudios Clínicos de Querétaro S.C.
      • Veracruz, Messico, 91900
        • FAICIC S. de R.L. de C.V.
    • Estado de Baja California
      • Tijuana, Estado de Baja California, Messico, 22500
        • CINCAME
    • Jalisco
      • Guadalajara, Jalisco, Messico, 44670
        • Centro de Investigacion Clinica Endocrinologica de Jalisco
      • Guadalajara, Jalisco, Messico, 44657
        • Consultorio Privado Dr Gabriel Arturo Ramos
    • Mexico City
      • Benito Juárez, Mexico City, Messico, 03300
        • Clinicos Asociados Bocm, S.C.
    • México, D.F.
      • Mexico City, México, D.F., Messico, 03300
        • Clinicos Asociados Bocm, S.C.
    • Nuevo León
      • Monterrey, Nuevo León, Messico, 64460
        • Unidad biomedica avanzada monterrey
      • Monterrey, Nuevo León, Messico, 64060
        • Cardiolink Clin Trials S.C.
      • Monterrey, Nuevo León, Messico, 64020
        • Internal Medicine Clin Trials
    • San Luis Potosí
      • San Luis Potosí City, San Luis Potosí, Messico, 78200
        • Centro de Atención e Investigación Cardiovascular del Potosí
    • Sinaloa
      • Culiacán, Sinaloa, Messico, 80230
        • Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.
      • Culiacán, Sinaloa, Messico, 80230
        • Centro para el Desarrollo de la Medicina y la Asistencia
      • Culiacán, Sinaloa, Messico, 80020
        • Hospital Angeles de Culiacan
  • Olanda
      • Alkmaar, Olanda, 1815 JD
        • Noordwest Ziekenhuisgroep
      • Almelo, Olanda, 7609 PP
        • Ziekenhuis Groep Twente Almelo
      • Almelo, Olanda, 7609 PP
        • ZGT Almelo - Cardiologie
      • Amsterdam, Olanda, 1105 AZ
        • Academisch Medisch Centrum
      • Amsterdam, Olanda, 1105 AZ
        • AmsterdamUMC AMC
      • Apeldoorn, Olanda, 7334 DZ
        • Gelre Ziekenhuizen Apeldoorn
      • Apeldoorn, Olanda, 7334 DZ
        • Gelre Zkh Apeldoorn Cardiologie
      • Breda, Olanda, 4818 CK
        • Amphia Ziekenhuis
      • Harderwijk, Olanda, 3844 DG
        • St Jansdal
      • Hilversum, Olanda, 1213 XZ
        • Tergooi, locatie Hilversum
      • Hilversum, Olanda, 1212 VG
        • Tergooi, Hilversum
      • Leiden, Olanda, 2333 ZA
        • Leids Universitair Medisch Centrum
      • Roosendaal, Olanda, 4708 AE
        • Bravis ziekenhuis
      • Roosendaal, Olanda, 4708 AE
        • Bravis Zkh Roosendaal
      • Rotterdam, Olanda, 3083 AN
        • Ikazia Ziekenhuis
      • Sneek, Olanda, 8601 ZR
        • D & A Research B.V.
      • Zaandam, Olanda, 1502 DV
        • Zaans Medisch Centrum
  • Polonia
      • Elblag, Polonia, 82-300
        • Centrum Kliniczno Badawcze
      • Grodzisk Mazowiecki, Polonia, 05-825
        • Samodzielny Publiczny Specjalistyczny Szpital Zachodni Im.Sw.Jana Pawla II
      • Krakow, Polonia, 31-202
        • Krakowski Szpital Specjalistyczny im. Jana Pawla II
      • Krakow, Polonia, 30-082
        • Specjalistyczna Praktyka Lekarska L. Bryniarski
      • Krakow, Polonia, 31-261
        • Praktyka Lekarska Mateusz Sidor
      • Lodz, Polonia, 93-338
        • Instytut Centrum Zdrowia Matki Polki
      • Lodz, Polonia, 90-338
        • Centrum Terapii Wspolczesnej
      • Lodz, Polonia, 90-338
        • Centrum Terapii Wspolczesnej J.M. Jasnorzewska S.K.A.
      • Lodz, Polonia, 91-211
        • Salve Medica
      • Ogrodzieniec, Polonia, 42-440
        • Specjalistyczna Praktyka Lekarska w Ogrodzieńcu
      • Poznan, Polonia, 61-848
        • Uniwersytecki Szpital Kliniczny w Poznaniu
      • Puławy, Polonia, 24-100
        • Velocity Nova Sp. z o.o.
      • Szczecin, Polonia, 70-341
        • CENTRUM MEDYCZNE VITA Praktyka Kardiologiczna
      • Tychy, Polonia, 43-100
        • Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach
      • Warsaw, Polonia, 00-710
        • NBR Polska Tomasz Klodawski
      • Warsaw, Polonia, 04-628
        • Narodowy Instytut Kardiologii Klin. Kard. i Ang.
      • Warsaw, Polonia, 04-628
        • Narodowy Instytut Kardiologii Klin. Kard. i Transp.
      • Wroclaw, Polonia, 51-162
        • Centrum Badan Klinicznych
      • Węgrów, Polonia, 07-100
        • Szpital Powiatowy Im. Hrabiego Stanislawa Lubienskiego Samodzielny Publiczny Zakład Opieki Zdrowotnej W Wegrowie
      • Zamość, Polonia, 22-400
        • Velocity Nova Sp. z o.o. Velocity Zamosc
    • Kuyavian-Pomeranian Voivodeship
      • Włocławek, Kuyavian-Pomeranian Voivodeship, Polonia, 87-800
        • Kardio Life - Tomasz Borkowski
    • Lesser Poland Voivodeship
      • Chrzanów, Lesser Poland Voivodeship, Polonia, 32-500
        • Malopolskie Centrum Sercowo-Naczyniowe
      • Krakow, Lesser Poland Voivodeship, Polonia, 31-261
        • Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Polonia, 50-981
        • 4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu
      • Wroclaw, Lower Silesian Voivodeship, Polonia, 51-134
        • Zdrowie S.C. Agnieszka I Donald Drozdz
    • Lublin Voivodeship
      • Lublin, Lublin Voivodeship, Polonia, 20-044
        • NZOZ "CenterMed Lublin" Sp. z o.o.
      • Poniatowa, Lublin Voivodeship, Polonia, 24-320
        • ETG Poniatowa
    • Lubusz Voivodeship
      • Gorzów Wielkopolski, Lubusz Voivodeship, Polonia, 66-400
        • Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski
    • Podlaskie Voivodeship
      • Bialystok, Podlaskie Voivodeship, Polonia, 15-481
        • Kresmed Sp. z o. o.
      • Bialystok, Podlaskie Voivodeship, Polonia, 15-540
        • Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio
    • Pomeranian Voivodeship
      • Gdynia, Pomeranian Voivodeship, Polonia, 81-157
        • Ind. Prak. Lek. w dziedz. Kardiologii lek. med. K. Cymerman
    • Silesian Voivodeship
      • Ruda Śląska, Silesian Voivodeship, Polonia, 41-710
        • AKA-MED Centrum
      • Ruda Śląska, Silesian Voivodeship, Polonia, 41-710
        • Poradnia AKA-MED Centrum Sp. z o.o.
    • Łódź Voivodeship
      • Lodz, Łódź Voivodeship, Polonia, 90-549
        • Uniwersytecki Szpital Kliniczny Nr 2 Uniwersytetu Medycznego w Lodzi
  • Portogallo
      • Almada, Portogallo, 2805-267
        • ULS De Almada-Seixal E.P.E. - Hospital Garcia de Orta
      • Aveiro, Portogallo, 3814-501
        • ULS Da Regiao De Aveiro E.P.E. - Hospital Infante D. Pedro
      • Braga, Portogallo, 4710-243
        • ULS De Braga, E.P.E. - Hospital de Braga
      • Coimbra, Portogallo, 3000-561
        • Unidade Local de Saúde de Coimbra, E.P.E.
      • Guilhufe - Penafiel, Portogallo, 4560-136
        • ULS De Tâmega e Sousa E.P.E. - Hospital Padre Américo
      • Lisbon, Portogallo, 1449-005
        • Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital São Francisco Xavier
      • Lisbon, Portogallo, 1649-035
        • Unidade Local De Saúde De Santa Maria E.P.E.
      • Lisbon, Portogallo, 1250-230
        • APDP - Associação Protectora dos Diabéticos de Portugal
      • Porto, Portogallo, 4200-319
        • ULS De São João, E.P.E. - Hospital de São João
      • Setúbal, Portogallo, 2910-446
        • ULS Da Arrábida, E.P.E._Hospital de São Bernardo
      • Viana do Castelo, Portogallo, 4904-858
        • ULS Do Alto Minho E.P.E. - Hospital de Santa Luzia
      • Vila Nova de Gaia, Portogallo, 4434-502
        • ULS De Gaia/Espinho E.P.E. - Hospital Eduardo Santos Silva
    • Lisbon District
      • Carnaxide, Lisbon District, Portogallo, 2790-134
        • Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital de Santa Cruz
    • Matosinhos
      • Senhora Da Hora, Matosinhos, Matosinhos, Portogallo, 4464-513
        • ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
  • Regno Unito
      • Barnet, Regno Unito, EN5 3DJ
        • Barnet Hospital - Cardiology Department
      • Birmingham, Regno Unito, B71 4HJ
        • Sandwell General Hospital
      • Bradford, Regno Unito, BD9 6RJ
        • Bradford Royal Infirmary
      • Bradford-on-Avon, Regno Unito, BA15 1DQ
        • The Health Centre
      • Bristol, Regno Unito, BS10 5NB
        • Southmead Hospital
      • Cambridge, Regno Unito, CB5 8PD
        • Addenbrooke's Hospital - Cambridge Dialysis Centre
      • Dorset, Regno Unito, BH16 5PW
        • The Adam Practice
      • Durham, Regno Unito, DL3 8SQ
        • Carmel Medical Practice
      • Exeter, Regno Unito, EX2 5DW
        • Royal Devon and Exeter Hospital
      • High Wycombe, Regno Unito, HP11 2TT
        • Wycombe General Hospital
      • Leicester, Regno Unito, LE5 4PW
        • Leicester General Hospital
      • Leicester, Regno Unito, LE3 9QP
        • Cardiology
      • Lincoln, Regno Unito, LN2 5QY
        • Lincoln County Hospital
      • Liverpool, Regno Unito, L9 7AL
        • Aintree University Hospital
      • Liverpool, Regno Unito, L14 3PE
        • Liverpool Heart & Chest Hospital
      • Liverpool, Regno Unito, L9 7AL
        • University Hospital Aintree
      • London, Regno Unito, SE5 9RS
        • King's College Hospital
      • London, Regno Unito, EC1M 6BQ
        • William Harvey Research Institute
      • London, Regno Unito, EC1M 6BQ
        • William Harvey Clinical Research Centre
      • Newcastle upon Tyne, Regno Unito, NE7 7DN
        • Freeman Hospital, Newcastle
      • Oxford, Regno Unito, OX3 9DU
        • John Radcliffe Hospital
      • Preston, Regno Unito, PR2 9RB
        • Panthera Biopartners Preston
      • Royal Leamington Spa, Regno Unito, CV32 4RA
        • Sherbourne Medical Centre
      • Stevenage, Regno Unito, SG1 4AB
        • Lister Hospital
      • Stockton-on-Tees, Regno Unito, TS19 8PE
        • University of North Tees Hospital
      • Taunton, Regno Unito, TA1 5DA
        • Musgrove Park Hospital
      • Torquay, Regno Unito, TQ2 7AA
        • Torbay Hospital - Cardiology
      • Wellingborough, Regno Unito, NN8 4RW
        • Albany House Medical Centre
    • Cheshire
      • Sandbach, Cheshire, Regno Unito, CW11 1EQ
        • Ashfields Primary Care Centre
    • Dorset
      • Bournemouth, Dorset, Regno Unito, BH7 7DW
        • Royal Bournemouth Hospital - Cardiology
      • Dorchester, Dorset, Regno Unito, DT1 2JY
        • Dorset County Hospital
    • Lancashire
      • Blackpool, Lancashire, Regno Unito, FY3 8NR
        • Blackpool Victoria Hospital
    • North Yorkshire
      • Pickering, North Yorkshire, Regno Unito, YO18 8BL
        • Pickering Medical Practice
    • Northamptonshire
      • Corby, Northamptonshire, Regno Unito, NN17 2UR
        • Lakeside Healthcare Research & Innovation Unit
    • Surrey
      • Addlestone, Surrey, Regno Unito, KT15 2BH
        • The Crouch Oak Family Practice
    • West Sussex
      • Chichester, West Sussex, Regno Unito, PO19 6SE
        • St. Richard's Hospital_Cardiology
  • Romania
      • Baia Mare, Romania, 430222
        • Cabinet Medical de Cardiologie Dr. Calin Pop
      • Brasov, Romania, 500283
        • Centrul Medical de Diagnostic si Tratament Ambulatoriu Neomed
      • Brasov, Romania, 500091
        • S.C. Centrul Medical Unirea S.R.L.
      • Brăila, Romania, 810325
        • Spitalul Judetean de Urgenta Braila
      • Bucharest, Romania, 050098
        • Spitalul Universitar de Urgenta Bucuresti
      • Bucharest, Romania, 011461
        • Spitalul Universitar de Urgenta Elias
      • Bucharest, Romania, 020475
        • Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila
      • Bucharest, Romania, 021875
        • Davius Clinicmed Srl
      • Bucharest, Romania, 011053
        • Hightech Medical Services S.R.L.
      • Bucharest, Romania, 012292
        • Lotus Med SRL
      • Bucharest, Romania, 014146
        • Centrul Medical Emerald
      • Bucharest, Romania, 042122
        • Spitalul Clinic de Urgenta "Sf. Ioan" Bucuresti
      • Bucharest, Romania, 020339
        • Donna Medplus S.R.L.
      • Buzău, Romania, 120133
        • Mat Cord Biomedica S.R.L.
      • Constanța, Romania, 900591
        • Spitalul Clinic Judetean De Urgenta Sfantul Apostol Andrei Constanta
      • Craiova, Romania, 200383
        • Neurocord Medical SRL
      • Craiova, Romania, 200513
        • Cardiomed SRL
      • Galati, Romania, 800291
        • SC Diamed Obesity SRL
      • Iași, Romania, 700503
        • Institutul de Boli Cardiovasculare "Prof. Dr. George I.M. Georgescu"
      • Iași, Romania, 700547
        • SC Consultmed SRL
      • Iași, Romania, 700732
        • SC Cardiomed SRL
      • Oradea, Romania, 410469
        • Spitalul Clinic Judetean de Urgenta Bihor
      • Paşcani, Romania, 705200
        • Bella Praxis S.R.L.
      • Piteşti, Romania, 110424
        • Sc Sal Med Srl
      • Timișoara, Romania, 300310
        • Institutul de Boli Cardiovasculare Timisoara
      • Timișoara, Romania, 300254
        • Spitalul Clinic Municipal de Urgenta Timisoara
      • Târgu Mureş, Romania, 540136
        • Spitalul Clinic Judetean de Urgenta Targu Mures
      • Târgu Mureş, Romania, 540143
        • CMI Dr. Cristian Podoleanu
    • Bucharest
      • Bucharest, Bucharest, Romania, 022328
        • Institutul Clinic Fundeni
    • Bucurestii
      • Bucharest, Bucurestii, Romania, 020475
        • Institutul National De Diabet Nutritie Si Boli Metabolice Prof.Dr.N.Paulescu Bucuresti- Ion Movila
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 400006
        • Clinic of Diabetes Cluj
  • Russia
      • Barnaul, Russia, 656055
        • RBSHI "Altay Regional Cardiology Dispensary"
      • Barnaul, Russia, 656024
        • Reg. State Budget Healthc. Inst. Regional Clinical Hospital
      • Chelyabinsk, Russia, 454048
        • Road Clinical Hospital at station Chelyabinsk
      • Chita, Russia, 672000
        • Chita State Medical Academy
      • Irkutsk, Russia, 664049
        • Irkutsk State Medical Academy of Postgraduate Education
      • Kazan', Russia, 420029
        • FSB EI "Kazan' State Medical University"
      • Kazan', Russia, 420101
        • SAI of Health "Interregional Clinic Diagnostic Center"
      • Kemerovo, Russia, 650002
        • Institute of Complex Problems of Cardio-Vascular Diseases
      • Moscow, Russia, 129226
        • Pirogov Russian National Research Medical University MoH
      • Moscow, Russia, 129327
        • Friendship University of Russia MCCH base
      • Moscow, Russia, 121552
        • National Medical Research Center of Cardiology
      • Novosibirsk, Russia, 630087
        • State Novosibirsk regional clinical hospital
      • Novosibirsk, Russia, 630099
        • Limited Law Company "Healthy Family" Medicine Center"
      • Novosibirsk, Russia, 630005
        • LLC RC Medical
      • Perm, Russia, 614068
        • SBIH Perm region "City Clinical Hospital #2 n.a. F.K. Gral"
      • Petrozavodsk, Russia, 185019
        • Republican Hospital n.a. V. A. Baranov
      • Saint Petersburg, Russia, 196084
        • Medical Research Institute LLC
      • Saint Petersburg, Russia, 199106
        • SPb BHI "City Pokrovskaya Hospital"
      • Samara, Russia, 443070
        • Regional Clinical cardiological dispensary n.a. Polyakov
      • Sochi, Russia, 354057
        • City Hospital #4, Sochi
      • Tomsk, Russia, 634034
        • Tomsk National Research Medical Center of the RAS
      • Tomsk, Russia, 634012
        • Tomsk National Research Medical Center of the RAS
  • Serbia
      • Belgrade, Serbia, 11080
        • Clinical Hospital Centre Zemun
      • Belgrade, Serbia, 11000
        • Clinical centre of Serbia, Clinic for cardiology
      • Belgrade, Serbia, 11000
        • Endocrinology, Diabetes and Metabolism Diseases Clinic
      • Belgrade, Serbia, 11000
        • Clinical Centre of Serbia, Emergency Centre, Department of Cardiology
      • Belgrade, Serbia, 11000
        • Emergency Internal Medicine Clinic
      • Belgrade, Serbia, 11000
        • CHC Zvezdara, Clinical department for endocrinology
      • Belgrade, Serbia, 11000
        • Institute for Cardiovascular Diseases ''Dedinje''
      • Kamenitz, Serbia, 21204
        • Institute for Cardiovascular Diseases of Vojvodina - Sremska Kamenica
      • Kragujevac, Serbia, 34000
        • Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department
      • Niš, Serbia, 18108
        • University Clinical Centre Nis, Clinic for Cardiology
      • Novi Sad, Serbia, 21000
        • Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
    • Vojvodina
      • Novi Sad, Vojvodina, Serbia, 21000
        • Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.
  • Slovacchia
      • Bratislava, Slovacchia, 811 04
        • CARDIOCONSULT, s.r.o.
      • Bratislava, Slovacchia, 81369
        • I. Interna klinika LF UK a UNB
      • Bratislava, Slovacchia, 831 06
        • DIABEDA s.r.o.
      • Bratislava, Slovacchia, 83348
        • Klinika kardiologie a angiologie LF SZU
      • Bratislava, Slovacchia, 841 03
        • CINRE s. r. o., Oddelenie akutnej kardiologie a koronarna JIS
      • Bratislava, Slovacchia, 83305
        • 1. Interna klinika SZU a UNB
      • Košice, Slovacchia, 040 01
        • Medical group Kosice s.r.o.
      • Levice, Slovacchia, 934 01
        • VITAL, s.r.o.
      • Lučenec, Slovacchia, 984 01
        • KARDIO 1, s.r.o., Kardiologicka ambulancia
      • Martin, Slovacchia, 036 59
        • 1. interna klinika, Univerzitna nemocnica Martin
      • Nitra, Slovacchia, 949 11
        • InterStom, s.r.o.
      • Nové Zámky, Slovacchia, 940 01
        • KARDIOMED NZ, s.r.o.
      • Piešťany, Slovacchia, 92101
        • Medical KG, s.r.o.
      • Považská Bystrica, Slovacchia, 017 01
        • Kardiologicka ambulancia
      • Prešov, Slovacchia, 08-181
        • FNsP J. A. Reimana Presov, Klinika kardiologie
      • Prešov, Slovacchia, 080 01
        • IMCORE, s.r.o.
      • Ľubochňa, Slovacchia, 03491
        • Narodny Endokrinologicky a diabetologicky ustav
  • Spagna
      • Barakaldo, Spagna, 48903
        • Hospital Universitario de Cruces
      • Castilleja de la Cuesta, Spagna, 41950
        • Hospital Vithas Sevilla
      • Córdoba, Spagna, 14004
        • Hospital Reina Sofia
      • L' Hospitalet Del Llobregat, Spagna, 08907
        • Bellvitge Universitary Hospital
      • Sanlúcar de Barrameda, Spagna, 11540
        • H Virgen del Camino_Sanlúcar_Medicina Interna
      • Valencia, Spagna, 46010
        • Hospital Clínico Universitario de Valencia
      • Valencia, Spagna, 46017
        • Hospital Universitario Doctor Peset
      • Villamartín, Spagna, 11650
        • Hosp. Virgen de las Montañas_Medicina Interna
      • Zaragoza, Spagna, 50009
        • Hospital Univ. Miguel Servet_Medicina Interna
    • Madrid
      • Majadahonda, Madrid, Spagna, 28222
        • Hospital Universitario Puerta de Hierro Majadahonda
    • Murcia
      • El Palmar, Murcia, Spagna, 30120
        • Hospital Univ. Virgen de la Arrixaca
  • Stati Uniti
    • Alabama
      • Birmingham, Alabama, Stati Uniti, 35233
        • Uni of Alabama at Birmingham
      • Montgomery, Alabama, Stati Uniti, 36106
        • Chambliss Clinical Trials LLC
    • Arizona
      • Glendale, Arizona, Stati Uniti, 85308
        • Lenzmeier Fam Med CCT Research
      • Mesa, Arizona, Stati Uniti, 85206
        • Aventiv Research Inc.
    • Arkansas
      • Little Rock, Arkansas, Stati Uniti, 72205
        • Univ of Arkansas Med Sciences
      • Searcy, Arkansas, Stati Uniti, 72143
        • Unity Health-Searcy Medical Center
    • California
      • Beverly Hills, California, Stati Uniti, 90211
        • National Heart Institute Cal
      • Chula Vista, California, Stati Uniti, 91910
        • California Inst Of Renal Res
      • Chula Vista, California, Stati Uniti, 91910
        • California Institute of Renal Research #10
      • Covina, California, Stati Uniti, 91723
        • Valley Clinical Trials
      • Huntington Park, California, Stati Uniti, 90255
        • Valiance Clinical Research
      • La Jolla, California, Stati Uniti, 92037
        • Scripps Wht Diab Inst La Jolla
      • La Mesa, California, Stati Uniti, 91942
        • Balboa Nephro Med Gr Inc LaMes
      • Lancaster, California, Stati Uniti, 93534
        • First Valley Medical Group
      • Loma Linda, California, Stati Uniti, 92357
        • VA Loma Linda Hlthcr Sys
      • Los Alamitos, California, Stati Uniti, 90720
        • Pacific Clinical Studies
      • Los Angeles, California, Stati Uniti, 90010
        • Angel City Research, Inc.
      • Lynwood, California, Stati Uniti, 90262
        • North America Research Institute
      • Newport Beach, California, Stati Uniti, 92663
        • Hoag Medical Group
      • Northridge, California, Stati Uniti, 91325
        • Valley Clinical Trials, Inc.
      • Palm Springs, California, Stati Uniti, 92262
        • Desert Oasis Hlthcr Med Group
      • Riverside, California, Stati Uniti, 92503
        • Riverside Nephrology Physicians
      • San Dimas, California, Stati Uniti, 91773
        • N America Res Inst - San Dimas
      • Torrance, California, Stati Uniti, 90502
        • Lundquist Inst-Biomed Innovtn
    • Colorado
      • Denver, Colorado, Stati Uniti, 80204
        • Denver Health Outpatient Medical Center
    • Connecticut
      • Bridgeport, Connecticut, Stati Uniti, 06610
        • Bridgeport Hospital
      • West Haven, Connecticut, Stati Uniti, 06516
        • VA-Connecticut (VACHS)
    • District of Columbia
      • Washington D.C., District of Columbia, Stati Uniti, 20037
        • George Washington Uni Med
    • Florida
      • Boca Raton, Florida, Stati Uniti, 33434
        • Excel Med Ctr Clinical Trials
      • Clearwater, Florida, Stati Uniti, 33756
        • Innovative Research of W FL
      • Delray Beach, Florida, Stati Uniti, 33445
        • Florida Premier Cardiology
      • Fleming Island, Florida, Stati Uniti, 32003
        • Northeast Research Institute
      • Fort Lauderdale, Florida, Stati Uniti, 33312
        • Integrative Research Assoc Inc
      • Hollywood, Florida, Stati Uniti, 33024
        • Encore Medical Research LLC
      • Hollywood, Florida, Stati Uniti, 33024
        • Elixia Pines
      • Jacksonville, Florida, Stati Uniti, 32216
        • Est Cst Inst for Rsrch,Jksnvil
      • Jacksonville, Florida, Stati Uniti, 32258
        • Baptist Heart Specialists
      • Jacksonville, Florida, Stati Uniti, 32204
        • Northeast Research Institute
      • Lakeland, Florida, Stati Uniti, 33805
        • Clinical Research of Cent FL
      • Miami, Florida, Stati Uniti, 33126
        • Pharmax Research Clinic
      • Miami, Florida, Stati Uniti, 33155
        • Allied Biomedical Research
      • Miami, Florida, Stati Uniti, 33130
        • Life Spring Research Foundation LLC
      • Miami Lakes, Florida, Stati Uniti, 33014
        • San Marcus Res Clin Miami Lakes
      • Miramar, Florida, Stati Uniti, 33027
        • Office of Kenneth Blaze DO
      • New Port Richey, Florida, Stati Uniti, 34652
        • Suncoast Clin Res Port Richey
      • Palm Harbor, Florida, Stati Uniti, 34684
        • Suncoast Clinical Research, Inc.
      • Pembroke Pines, Florida, Stati Uniti, 33024
        • A&R Research Group, LLC
      • Port Charlotte, Florida, Stati Uniti, 33952
        • Hanson Clinical Research Center
      • Port Charlotte, Florida, Stati Uniti, 33952
        • Peace River Cardiovascular Center
      • Saint Augustine, Florida, Stati Uniti, 32080
        • Northeast Research Institute
      • Saint Augustine, Florida, Stati Uniti, 32086
        • St Johns Center for Clin. Res
      • Saint Augustine, Florida, Stati Uniti, 32086
        • East Coast Institute for Research LLC_St. Augustine
    • Georgia
      • Albany, Georgia, Stati Uniti, 31707
        • Javara/Privia Med Grp GA,LLC
      • Augusta, Georgia, Stati Uniti, 30904
        • Southeastern Clinical Research Institute, LLC
      • Augusta, Georgia, Stati Uniti, 30904
        • Southeastern Clinical R.I.
      • Conyers, Georgia, Stati Uniti, 30094
        • Hope Clin Res & Wellness
      • Fayetteville, Georgia, Stati Uniti, 30214
        • Javara Inc._Albany
      • Johns Creek, Georgia, Stati Uniti, 30024
        • NSC Research, Inc
      • Roswell, Georgia, Stati Uniti, 30076
        • Endo Res Solutions Inc
      • Savannah, Georgia, Stati Uniti, 31406
        • Javara Inc._Winston Salem
    • Idaho
      • Nampa, Idaho, Stati Uniti, 83686-6011
        • Saltzer Medical Group Research
    • Illinois
      • Arlington Heights, Illinois, Stati Uniti, 60005
        • Endeavor Health Clinical Operations-NCH
      • Chicago, Illinois, Stati Uniti, 60643
        • Research by Design LLC
      • Gurnee, Illinois, Stati Uniti, 60031
        • Clinical Invest Special_Gurnee
      • Hazel Crest, Illinois, Stati Uniti, 60429
        • Chicago Medical Research LLC
      • Skokie, Illinois, Stati Uniti, 60077
        • Endeavor Health
      • Springfield, Illinois, Stati Uniti, 62711
        • Central Illinois Diabetes and Clinical Research
      • Wauconda, Illinois, Stati Uniti, 60084
        • Clin Invest Spec, Inc
    • Indiana
      • Evansville, Indiana, Stati Uniti, 47714
        • MediSphere Medical RC
      • Valparaiso, Indiana, Stati Uniti, 46383
        • Velocity Clin. Res Valparaiso
    • Kansas
      • Overland Park, Kansas, Stati Uniti, 66211
        • Midwest Heart & Vasc Spec
      • Topeka, Kansas, Stati Uniti, 66606
        • Cotton O'Neil Diab & Endo Ctr
    • Kentucky
      • Lexington, Kentucky, Stati Uniti, 40503
        • The Research Group of Lexington LLC
      • Lexington, Kentucky, Stati Uniti, 40502
        • Lexington VA Health Care System
      • Louisville, Kentucky, Stati Uniti, 40205
        • Norton Heart Specialists-Springs
    • Louisiana
      • Bossier City, Louisiana, Stati Uniti, 71111
        • Grace Research, LLC
      • Monroe, Louisiana, Stati Uniti, 71201
        • Ima Clinical Research
      • Monroe, Louisiana, Stati Uniti, 71201
        • Clinical Trials of Ame, LLC
      • Shreveport, Louisiana, Stati Uniti, 71105
        • Grace Research, LLC_Shreveport
      • Slidell, Louisiana, Stati Uniti, 70458
        • Louisiana Heart Center_Slidell
    • Maryland
      • Annapolis, Maryland, Stati Uniti, 21401
        • Anne Arundel Medical Center
      • Bethesda, Maryland, Stati Uniti, 20814
        • Suburban Hospital
      • Clinton, Maryland, Stati Uniti, 20735
        • John P Hakim MD and Associates
    • Massachusetts
      • Boston, Massachusetts, Stati Uniti, 02115-5804
        • Brigham & Women's Hospital
      • Haverhill, Massachusetts, Stati Uniti, 01830
        • Pentucket Medical Associates
    • Michigan
      • Detroit, Michigan, Stati Uniti, 48202
        • Henry Ford Hospital_Detroit
      • Flint, Michigan, Stati Uniti, 48532
        • Elite Research Center
      • Grand Rapids, Michigan, Stati Uniti, 49546
        • Healthy Heart Cardiology
      • Petoskey, Michigan, Stati Uniti, 49770
        • McLaren Northern MI Hosp
    • Minnesota
      • Minneapolis, Minnesota, Stati Uniti, 55407
        • AHS dba Abbot NW Hosp Diab Cen
      • Minneapolis, Minnesota, Stati Uniti, 55455
        • University of Minnesota_Minneapolis_1
    • Missouri
      • Kansas City, Missouri, Stati Uniti, 64111
        • Clinical Research Consultants, LLC
      • St Louis, Missouri, Stati Uniti, 63136
        • St Louis Heart & Vascular, P.C.
      • St Louis, Missouri, Stati Uniti, 63128
        • Gateway CV Research Cntr Inc.
    • Nebraska
      • Lincoln, Nebraska, Stati Uniti, 68526
        • Nebraska Heart Institute_Lincoln
      • Omaha, Nebraska, Stati Uniti, 68105
        • VA NEB - Western IA Health Stm
      • Omaha, Nebraska, Stati Uniti, 68198-3020
        • Univ of Nebraska Medical CTR
      • Omaha, Nebraska, Stati Uniti, 68114
        • Methodist Phys Clin Heart Cons
    • Nevada
      • Las Vegas, Nevada, Stati Uniti, 89102
        • University of Nevada School of Medicine
      • Las Vegas, Nevada, Stati Uniti, 89128
        • Palm Research Center Inc-Vegas
    • New Jersey
      • Bridgewater, New Jersey, Stati Uniti, 08807-3064
        • Advanced Heart Care LLC
    • New Mexico
      • Albuquerque, New Mexico, Stati Uniti, 87106
        • Uni of New Mexico-Clinical
    • New York
      • Mineola, New York, Stati Uniti, 11501
        • NYU Nephrology Associates
      • New York, New York, Stati Uniti, 10016
        • NYU Grossman School of Med
      • New York, New York, Stati Uniti, 10019
        • Mount Sinai Hosp at NYC
      • Northport, New York, Stati Uniti, 11768
        • Northport VA Med Ctr Northport
      • Ridgewood, New York, Stati Uniti, 11385
        • Mattoo & Bhat M.A.
      • Saratoga Springs, New York, Stati Uniti, 12866
        • Saratoga Clinical Research
      • The Bronx, New York, Stati Uniti, 10461
        • DaVita Clinical Research - New York
      • West Seneca, New York, Stati Uniti, 14224
        • Southgate Medical Group, LLP
      • Westfield, New York, Stati Uniti, 14787
        • Great Lakes Medical Research
    • North Carolina
      • Asheville, North Carolina, Stati Uniti, 28801
        • Mountain Kidney & Hypertension Associates
      • Burlington, North Carolina, Stati Uniti, 27215
        • Kernodle Clin Dpt-Pvt Diagnost
      • Chapel Hill, North Carolina, Stati Uniti, 27599
        • UNC- Chapel Hill
      • Charlotte, North Carolina, Stati Uniti, 28208
        • Metrolina Nephrology Associates, PA
      • Charlotte, North Carolina, Stati Uniti, 28210
        • Javara Inc._Charlotte
      • Greensboro, North Carolina, Stati Uniti, 27408
        • PharmQuest Life Sciences LLC
      • Greenville, North Carolina, Stati Uniti, 27834
        • Physicians East Endocrinology
      • Morehead City, North Carolina, Stati Uniti, 28557
        • Carteret Medical Group
    • North Dakota
      • Fargo, North Dakota, Stati Uniti, 58104
        • Lillestol Research LLC
    • Ohio
      • Cincinnati, Ohio, Stati Uniti, 45267
        • Univ of Cincinnati Med Cent
      • Cleveland, Ohio, Stati Uniti, 44106
        • VA Northeast Ohio Healthcare System (VANEOHS)
      • Maumee, Ohio, Stati Uniti, 43537
        • Advanced Med Res Maumee
    • Pennsylvania
      • Bethlehem, Pennsylvania, Stati Uniti, 18017
        • Northeast Clinical Research Center
      • Philadelphia, Pennsylvania, Stati Uniti, 19144
        • Parkside Family Medicine
      • Philadelphia, Pennsylvania, Stati Uniti, 19114
        • Aria Endocrine Metabolic Assoc
    • Rhode Island
      • Lincoln, Rhode Island, Stati Uniti, 02865
        • Ocean St Clin Res Partnrs, LLC
    • South Carolina
      • Fort Mill, South Carolina, Stati Uniti, 29707
        • Piedmont Research Partners, LLC
      • Greenville, South Carolina, Stati Uniti, 29615
        • Palmetto Clinical Research
      • Myrtle Beach, South Carolina, Stati Uniti, 29588
        • Family Medicine of SayeBrook LLC
      • Spartanburg, South Carolina, Stati Uniti, 29303
        • Spartanburg Medical Research
    • Tennessee
      • Chattanooga, Tennessee, Stati Uniti, 37411
        • Univ Diab & Endo Consultants
      • Greeneville, Tennessee, Stati Uniti, 37745
        • Balad Hlth Sys-Welmont CardCVA
      • Knoxville, Tennessee, Stati Uniti, 37934
        • Tennova HC Turkey Creek MC
      • Memphis, Tennessee, Stati Uniti, 38119
        • Clinical Neuroscience Solutions
      • Powell, Tennessee, Stati Uniti, 37849
        • CV Research of Knoxville
    • Texas
      • Arlington, Texas, Stati Uniti, 76012-4637
        • Arlington Family Res. Ctr Inc
      • Arlington, Texas, Stati Uniti, 76002
        • Liberty Research Center
      • Bellaire, Texas, Stati Uniti, 77401
        • Novel Research LLC
      • Corpus Christi, Texas, Stati Uniti, 78414
        • Osvaldo A. Brusco MD
      • Cypress, Texas, Stati Uniti, 77429
        • Research Trials Worldwide LLC
      • Dallas, Texas, Stati Uniti, 75204
        • Renal Disease Research Institute
      • Dallas, Texas, Stati Uniti, 75208
        • Thyroid Endocrinology & Diabetes PA
      • Dallas, Texas, Stati Uniti, 75230
        • Liberty Research Center_Dallas
      • Edinburg, Texas, Stati Uniti, 78539
        • DHR Health Inst for Res & Dev
      • El Paso, Texas, Stati Uniti, 79935
        • Academy of Diabetes, T&E
      • Forney, Texas, Stati Uniti, 75126
        • Care United Research, LLC
      • Fort Worth, Texas, Stati Uniti, 76132
        • Diabetes and Thyroid Ctr of FW
      • Fort Worth, Texas, Stati Uniti, 76133
        • Javara /TX.Hlth LLC dba Prvia
      • Houston, Texas, Stati Uniti, 77084
        • Biopharma Informatic, LLC
      • Houston, Texas, Stati Uniti, 77024
        • Primecare Medical Group
      • Houston, Texas, Stati Uniti, 77054
        • Prolato Clinical Research Center
      • Houston, Texas, Stati Uniti, 77079
        • PlanIt Research, PLLC
      • Houston, Texas, Stati Uniti, 77043
        • Biopharma Informatic_Houston
      • Houston, Texas, Stati Uniti, 77054
        • Prolato Clinical Research Cntr
      • Houston, Texas, Stati Uniti, 77030
        • Baylor College Of Medicine_Houston
      • Houston, Texas, Stati Uniti, 77070
        • Card Specialists of Willowbrook
      • Houston, Texas, Stati Uniti, 77090
        • Biopharma Informatic_Houston_0
      • Houston, Texas, Stati Uniti, 77030
        • Baylor College Of Medicine_Houston Travis Street
      • Longview, Texas, Stati Uniti, 75605
        • DCOL Ctr for Clin Res
      • Lufkin, Texas, Stati Uniti, 75904
        • Texas Inst, Kdny & Endo Disor
      • McAllen, Texas, Stati Uniti, 78503
        • RGV Endocrine Center
      • Rockwall, Texas, Stati Uniti, 75032
        • Carlos Arauz-Pacheco Md, Pa
      • San Antonio, Texas, Stati Uniti, 78229
        • University Hospital
      • San Antonio, Texas, Stati Uniti, 78215
        • Sun Research Institute
      • San Antonio, Texas, Stati Uniti, 78212
        • Clinical Advancement Center
      • San Antonio, Texas, Stati Uniti, 78230
        • VIP Trials
      • San Antonio, Texas, Stati Uniti, 78224
        • Briggs Clinical Research, LLC
      • San Antonio, Texas, Stati Uniti, 78233
        • NE Clin Res of San Antonio
      • San Marcos, Texas, Stati Uniti, 78666
        • Javara Privia Grp Gulf Cst LLC
      • Sugar Land, Texas, Stati Uniti, 77478
        • Simcare Medical Research, LLC
      • Waco, Texas, Stati Uniti, 76708
        • Hillcrest Family Health Center
    • Utah
      • Salt Lake City, Utah, Stati Uniti, 84108
        • University of Utah School of Medicine
    • Virginia
      • Forest, Virginia, Stati Uniti, 24551
        • Javara Inc/Privia Md GpLLC Fst
      • Norfolk, Virginia, Stati Uniti, 23504
        • York Clinical Research LLC
      • Richmond, Virginia, Stati Uniti, 23298
        • Virginia Commonwealth University Health System
      • Salem, Virginia, Stati Uniti, 24153-6404
        • VA Medical Center_Salem
      • Winchester, Virginia, Stati Uniti, 22601-3834
        • Selma Medical Associates
    • Washington
      • Spokane, Washington, Stati Uniti, 99204
        • Providence Medical Research Center
    • Wisconsin
      • Wausau, Wisconsin, Stati Uniti, 54401
        • Aspirus Research Institute
      • Weston, Wisconsin, Stati Uniti, 54476
        • Marshfield Clinic
  • Sud Africa
    • Eastern Cape
      • George, Eastern Cape, Sud Africa, 6529
        • Excellentis Clinical Trial Consultants
    • Free State
      • Bloemfontein, Free State, Sud Africa, 9301
        • Josha Research
      • Bloemfontein, Free State, Sud Africa, 9301
        • Iatros International
      • Bloemfontein, Free State, Sud Africa, 9301
        • Cardiology Research_Bloemfontein
    • Gauteng
      • Centurion, Gauteng, Sud Africa, 0157
        • Dr Iftikhar Osman Ebrahim
      • Johannesburg, Gauteng, Sud Africa, 2193
        • Wits Clinical Research
      • Johannesburg, Gauteng, Sud Africa, 2013
        • Wits Bara Clinical Trial Site
      • Johannesburg, Gauteng, Sud Africa, 2157
        • Tickerdoc Research (Pty) LTD
      • Pretoria, Gauteng, Sud Africa, 0184
        • Synexus Watermeyer Clinical Research Centre
      • Pretoria, Gauteng, Sud Africa, 0183
        • Jongaie Research
      • Pretoria, Gauteng, Sud Africa, 0186
        • Clinical Trial Systems (CTC)
      • Pretoria, Gauteng, Sud Africa, 0002
        • EMMED Clinical Research
      • Roodepoort, Gauteng, Sud Africa, 1724
        • Roodepoort Medicross Clinical Research Centre
    • KwaZulu-Natal
      • Tongaat, KwaZulu-Natal, Sud Africa, 4400
        • Mediclinic Medical Centre
    • Western Cape
      • Cape Town, Western Cape, Sud Africa, 7530
        • Tiervlei Trial Centre
      • Cape Town, Western Cape, Sud Africa, 7500
        • Tread Research (Pty)Ltd
      • Cape Town, Western Cape, Sud Africa, 7925
        • Prof Rayner_Division of Nephrology
      • Cape Town, Western Cape, Sud Africa, 7130
        • Helderberg Research Institute
      • George, Western Cape, Sud Africa, 6529
        • TASK Eden Clinical Research Centre
      • Mossel Bay, Western Cape, Sud Africa, 6500
        • Dr Hendrik Snyman's Practice
      • Paarl, Western Cape, Sud Africa, 7646
        • Paarl Reserch Centre
      • Paarl, Cape Town, Western Cape, Sud Africa, 7646
        • Paarl Research Centre
      • Somerset West, Western Cape, Sud Africa, 7130
        • Synexus Helderberg Clinical Research Centre
      • Somerset West, Western Cape, Sud Africa, 7130
        • Clinical Trials Network Helderberg
  • Svezia
      • Gothenburg, Svezia, 413 45
        • Njurmedicin Sahlgrenska - SU
      • Lund, Svezia, 222 21
        • Clemenstorgets Hjartmottagning
      • Malmo, Svezia, 205 02
        • Forskningsmottagning Internmedicin (tidigare KFE)
      • Stockholm, Svezia, 171 64
        • Karolinska Universitetssjukhuset Solna,FOU Tema Hjärta Kärl
      • Uppsala, Svezia, 751 85
        • Forskning njurmedicin Uppsala
      • Örebro, Svezia, 70185
        • Njursektionen Medicinkliniken Örebro UH
    • Stockholm County
      • Huddinge, Stockholm County, Svezia, 141 85
        • Karolinska Universitetssjukhuset, Huddinge
  • Tailandia
      • Bangkok, Tailandia, 10330
        • King Chulalongkorn Memorial Hospital
      • Bangkok, Tailandia, 10700
        • Siriraj Hospital
      • Bangkok, Tailandia, 10300
        • Cardio-Vajira
      • Bangkok, Tailandia, 10300
        • Vajira Hospital - Cardio
      • Bangkok, Tailandia, 10210
        • Chulabhorn hospital_Cardiovascular
      • Chiang Mai, Tailandia, 50200
        • Maharaj Nakorn Chiang Mai Hospital
      • Chiang Mai, Tailandia, 50200
        • Rihes - Research Institute for Health Sciences
      • Chiang Mai, Tailandia, 50200
        • RIHES-CMU_Research Institute for Health Sciences
      • Khon Kaen, Tailandia, 40002
        • Srinagarind Hospital
      • Nakhon Ratchasima, Tailandia, 30000
        • Maharat Nakhon Ratchasima Hospital
      • Pathum Thani, Tailandia, 12120
        • Thammasat Hospital_Cardiology
      • Songkhla, Tailandia, 90110
        • Songklanagarind hospital
      • Ubon Ratchathani, Tailandia, 34000
        • Sunpasitthiprasong Hospital
      • Ubon Ratchathani, Tailandia, 34000
        • Sunpasitthiprasong Hospital_Pediatrics Department
    • Bangkok
      • Bangkok Noi, Bangkok, Tailandia, 10700
        • Siriraj Hospital
    • Changwat Pathum Thani
      • Klong Luang, Pathumthani, Changwat Pathum Thani, Tailandia, 12120
        • Thammasat University Hospital
    • Changwat Songkhla
      • Hat Yai, Changwat Songkhla, Tailandia, 90110
        • Songklanagarind hospital
    • Mueang Chiang Mai
      • Chiang Mai, Mueang Chiang Mai, Tailandia, 50200
        • Maharaj Nakorn Chiang Mai Hospital_Nephrology
    • Patumwan
      • Bangkok, Patumwan, Tailandia, 10330
        • King Chulalongkorn Memorial Hospital
    • Rajathewee
      • Bangkok, Rajathewee, Tailandia, 10400
        • Phramongkutklao Hospital_Nephrology
    • Thung Phayathai Subdistrict
      • Bangkok, Thung Phayathai Subdistrict, Tailandia, 10400
        • Ramathibodi Hospital
  • Taiwan
      • Hsinchu, Taiwan, 300
        • HsinChu MacKay Memorial Hospital
      • Kaohsiung City, Taiwan, 807
        • Kaohsiung Medical University Chung-Ho Memorial Hospital
      • Kaohsiung City, Taiwan, 82445
        • E-DA Hospital-Department of Cardiology
      • Tainan, Taiwan, 704
        • National Cheng Kung University Hospital
      • Tainan, Taiwan, 710
        • Chi Mei Medical Center
      • Taipei, Taiwan, 110
        • Taipei Medical University Hospital
      • Taipei, Taiwan, 112
        • Taipei Veterans General Hospital
      • Taipei, Taiwan, 112
        • Cheng Hsin General Hospital
      • Taipei, Taiwan, 100
        • National Taiwan University Hospital_main
      • Taoyuan District, Taiwan, 333
        • Chang Gung Memorial Hospital, Linkou
      • Yilan, Taiwan, 260006
        • National Yang Ming Chiao Tung University Hospital Lanyang Campus
  • Turchia (Türkiye)
      • Afyonkarahisar, Turchia (Türkiye), 03200
        • Afyonkarahisar Health Sciences University
      • Afyonkarahisar, Turchia (Türkiye), 03200
        • Afyonkarahisar Sağlık Bilimleri Üniversitesi Sağlık Uygulama Ve Araştırma Merkezi- Kardiyoloji
      • Ankara, Turchia (Türkiye), 06230
        • Hacettepe Universitesi Tip Fakultesi Nefroloji Bilim Dali
      • Ankara, Turchia (Türkiye), 06230
        • Hacettepe University Medical Faculty_Ankara
      • Ankara, Turchia (Türkiye), 06230
        • Hacettepe Üniversitesi Hastanesi- Kardiyoloji
      • Ankara, Turchia (Türkiye), 06230
        • Hacettepe Üniversitesi Hastanesi- Nefroloji
      • Ankara, Turchia (Türkiye), 06800
        • Ankara Bilkent Şehir Hastanesi-Kardiyoloji
      • Antalya, Turchia (Türkiye), 07058
        • Akdeniz Universitesi Hastanesi Nefroloji Bilim Dali
      • Antalya, Turchia (Türkiye), 07058
        • Akdeniz Üniversitesi Hastanesi-Nefroloji
      • Aydin, Turchia (Türkiye), 09100
        • Aydın Adnan Menderes Üniversitesi Hastanesi- Nefroloji
      • Edirne, Turchia (Türkiye), 22030
        • Trakya Üniversitesi Tıp Fakültesi Hastanesi- Kardiyoloji
      • Eskişehir, Turchia (Türkiye), 26040
        • Eskisehir Osmangazi University-Cardio
      • Eskişehir, Turchia (Türkiye), 26040
        • Eskişehir Osmangazi Üniversitesi Hastanesi- Kardiyoloji
      • Istanbul, Turchia (Türkiye), 34381
        • Istanbul Florence Nightingale Hospital
      • Istanbul, Turchia (Türkiye), 34668
        • Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi EAH- Kardiyoloji
      • Istanbul, Turchia (Türkiye), 34098
        • İstanbul Üniversitesi-Cerrahpaşa Kardiyoloji Enstitüsü
      • Izmir, Turchia (Türkiye), 35100
        • Ege Üniversitesi Hastanesi- Kardiyoloji
      • Izmir, Turchia (Türkiye), 35340
        • Dokuz Eylül Üniversitesi Araştırma Uygulama Hastanesi-Kardiyoloji
      • Kahramanmaraş, Turchia (Türkiye), 46040
        • Kahramanmaraş Sütçü İmam University
      • Kayseri, Turchia (Türkiye), 38039
        • Erciyes University Medial Faculty
      • Kocaeli, Turchia (Türkiye), 41380
        • Kocaeli University Nephrology Department
      • Kocaeli, Turchia (Türkiye), 41380
        • Kocaeli Üniversitesi Araştıma ve Uygulama Hastanesi - Nefroloji
      • Mersin, Turchia (Türkiye), 33343
        • Mersin Üniversitesi Hastanesi- Kardiyoloji
      • Muğla, Turchia (Türkiye), 48050
        • Muğla Eğitim Ve Araştırma Hastanesi
    • Bakirkoy
      • Istanbul, Bakirkoy, Turchia (Türkiye), 34153
        • Istanbul University Cerrahpasa Medical Faculty
      • Istanbul, Bakirkoy, Turchia (Türkiye), 34098
        • İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Hastanesi- Nefroloji
    • Melikgazi
      • Kayseri, Melikgazi, Turchia (Türkiye), 38039
        • Erciyes Üniversitesi Hastanesi - Nefroloji
  • Ucraina
      • Chernivtsi, Ucraina, 58023
        • Reg Clin Hospital of Emergency Care, Bukovinian Medical Univ
      • Chernivtsi, Ucraina, 58023
        • Chernivtsi Emergency Hospital - Therapeutic Department No.1
      • Ivano-Frankivsk, Ucraina, 76008
        • Сlinical treatment and diagnostic centre 'Simedgroup'
      • Kharkiv, Ucraina, 61039
        • NI of Therapy na LT Malaya of NAMSU - Chr. Non-Communicable
      • Kharkiv, Ucraina, 61178
        • Municipal Non-Profit Institution "City Clinical Hospital #8"
      • Kharkiv, Ucraina, 61002
        • City Clinical Hospital #27 (Kharkiv) - Intensive care department
      • Kharkiv, Ucraina, 61039
        • Institute of Therapy named after L.T.Malaya - Department of Prevention and Treatment of Kidney Diseases in Comorbid Conditions
      • Kharkiv, Ucraina, 61178
        • City Clinical Hospital #8 (Kharkiv) - Dept of Arterial and Ven Thrombosis
      • Kyiv, Ucraina, 03037
        • Medbud-Clinic LLC
      • Kyiv, Ucraina, 02660
        • Kyiv City Clinical Hospital of Emergency Care - Infarction
      • Kyiv, Ucraina, 03049
        • Clinical Hosp on the railway line №2 branch PHC JSC Ukrzaliz
      • Kyiv, Ucraina, 03049
        • Kyiv Railway Clinical Hospital #2 - day care department
      • Kyiv, Ucraina, 02660
        • Kyiv City Clinical Hospital of Emergency Care - Infarction department
      • Kyiv, Ucraina, 03037
        • "Medbud-Clinic" LLC - medical and preventive unit
      • Kyiv, Ucraina, 02091
        • Medical Centre "OkClinic +" - inpatient department
      • Kyiv, Ucraina, 03151
        • M.D.Strazheska Institute of Cardiology of NAMSU - Intensive care and resuscitation department
      • Kyiv, Ucraina, 03680
        • M.D.Strazheska Institute of Cardiology of NAMSU - Department of non-coronary heart diseases
      • Kyiv, Ucraina, 04050
        • Medical Center 'Consilium Medical' - clinical consultation department
      • Kyiv, Ucraina, 04053
        • Kyiv Regional Clinical Hospital - Consultative medical department
      • Kyiv, Ucraina, 04210
        • "Center of Family Medicine Plus" LLC - Outpatient department
      • Zaporizhia, Ucraina, 69001
        • City Clinical Hospital #10 (Zaporizhia) - Therapeutics department
      • Zaporizhzhia, Ucraina, 69063
        • University Clinic of Zaporizhia State Medical and Pharm University - Cardiology department
      • Zhytomyr, Ucraina, 10002
        • Central City Hospital #1 - Scientific-Research centre
  • Ungheria
      • Baja, Ungheria, 6500
        • EURÉKA-CENTER Orvosi és Szolgáltató Betéti Társaság
      • Balatonfüred, Ungheria, 8230
        • Tagore Medical Center
      • Budapest, Ungheria, 1204
        • Jahn Ferenc Del-pesti Korhaz es Rendelointezet
      • Budapest, Ungheria, 1096
        • Gottsegen György Országos Kardiológiai Intézet
      • Debrecen, Ungheria, 4032
        • DE KK Kardiológiai és Szívsebészeti klinika
      • Szeged, Ungheria, 6725
        • Szegedi Tudomanyegyetem St Györgyi Albert Klinikai Központ
    • Bekes County
      • Békéscsaba, Bekes County, Ungheria, 5600
        • Dr. Lakatos Ferenc Kardiológus ,Belgyógyász Magán szakrendelés
    • Komárom-Esztergom
      • Komárom, Komárom-Esztergom, Ungheria, 2921
        • Selye János Kórház
    • Zala County
      • Zalaegerszeg, Zala County, Ungheria, 8900
        • Léda Platán Magánklinika

Criteri di partecipazione

I ricercatori cercano persone che corrispondano a una certa descrizione, chiamata criteri di ammissibilità. Alcuni esempi di questi criteri sono le condizioni generali di salute di una persona o trattamenti precedenti.

Criteri di ammissibilità

Età idonea allo studio

18 anni e precedenti (Adulto, Adulto più anziano)

Accetta volontari sani

No

Descrizione

Criterio di inclusione:

  • Velocità di filtrazione glomerulare stimata (eGFR) 15 e inferiore a 60 mL/min/1,73 m^2 (utilizzando l'equazione della creatinina della Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI))
  • Proteina C-reattiva ad alta sensibilità (hs-CRP) sierica maggiore o uguale a 2 mg/L allo screening (visita 1)

  • Evidenza di malattia cardiovascolare aterosclerotica (ASCVD) da uno o più dei seguenti:

    a) Malattia coronarica definita come almeno una delle seguenti: i. Storia documentata di MI ii. Precedente procedura di rivascolarizzazione coronarica iii. stenosi maggiore o uguale al 50% dell'arteria coronaria epicardica maggiore documentata da cateterismo cardiaco o angiografia coronarica TC b) Malattia cerebrovascolare definita come almeno una delle seguenti: i. Precedente ictus di origine aterosclerotica ii. Precedente procedura di rivascolarizzazione dell'arteria carotidea iii. stenosi maggiore o uguale al 50% nell'arteria carotidea documentata da angiografia a raggi X, angiografia RM, angiografia TC o ecografia Doppler.

    c) Arteriopatia periferica sintomatica (PAD) definita come almeno una delle seguenti: i. Claudicatio intermittente con indice caviglia-braccio (ABI) inferiore o uguale a 0,90 a riposo ii. Claudicatio intermittente con una stenosi maggiore o uguale al 50% dell'arteria periferica (carotide esclusa) documentata da angiografia a raggi X, angiografia RM, angiografia TC o ecografia Doppler iii. Precedente procedura di rivascolarizzazione dell'arteria periferica (esclusa la carotide) iv. Amputazione degli arti inferiori in corrispondenza o sopra la caviglia dovuta a malattia aterosclerotica (esclusi ad es. trauma o osteomielite).

Criteri di esclusione:

  • Evidenza clinica o sospetto di infezione attiva a discrezione dello sperimentatore.
  • Infarto del miocardio, ictus, ricovero per angina pectoris instabile o attacco ischemico transitorio entro 60 giorni prima della randomizzazione (visita 2).
  • Rivascolarizzazione coronarica, carotidea o periferica pianificata nota il giorno dello screening (visita 1).
  • - Interventi di chirurgia cardiaca maggiore, chirurgia non cardiaca o endoscopica maggiore (toracoscopica o laparoscopica) negli ultimi 60 giorni prima della randomizzazione (visita 2) o qualsiasi intervento di chirurgia maggiore pianificato al momento della randomizzazione (visita 2).

Piano di studio

Questa sezione fornisce i dettagli del piano di studio, compreso il modo in cui lo studio è progettato e ciò che lo studio sta misurando.

Come è strutturato lo studio?

Dettagli di progettazione

  • Scopo principale: Trattamento
  • Assegnazione: Randomizzato
  • Modello interventistico: Assegnazione parallela
  • Mascheramento: Quadruplicare

Armi e interventi

Gruppo di partecipanti / Arm
Intervento / Trattamento
Sperimentale: Ziltivekimab
I partecipanti riceveranno Ziltivekimab B o Ziltivekimab C per via sottocutanea una volta al mese per un massimo di 4 anni.
Droga: Ziltivekimab B
Somministrato per via sottocutanea (s.c., sotto la pelle) una volta al mese in aggiunta allo standard di cura.
Droga: Ziltivekimab C
Somministrato per via sottocutanea (s.c., sotto la pelle) una volta al mese in aggiunta allo standard di cura.
Comparatore placebo: Placebo
I partecipanti riceveranno placebo (Ziltivekimab B) o placebo (Ziltivekimab C) per via sottocutanea una volta al mese per un massimo di 4 anni.
Droga: Placebo (Ziltivekimab B)
Somministrato per via sottocutanea (s.c., sotto la pelle) una volta al mese in aggiunta allo standard di cura.
Droga: Placebo (Ziltivekimab C)
Somministrato per via sottocutanea (s.c., sotto la pelle) una volta al mese in aggiunta allo standard di cura.

Cosa sta misurando lo studio?

Misure di risultato primarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Tempo alla prima occorrenza di un evento cardiovascolare avverso maggiore (MACE) su 3 punti, un endpoint composito costituito da: morte cardiovascolare (CV), infarto miocardico (IM) non fatale e ictus non fatale
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)

Misure di risultato secondarie

Misura del risultato
Misura Descrizione
Lasso di tempo
Tempo alla prima occorrenza di ciascuno dei singoli componenti dell'endpoint MACE espanso e dell'endpoint composito del rene.
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Tempo alla prima occorrenza di IM (fatale e non fatale).
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Tempo alla prima occorrenza di ictus (fatale e non fatale).
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Tempo alla prima occorrenza di rivascolarizzazione coronarica
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Variazione del rapporto tra abumina e ceatinina urinaria (UACR).
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi).
Percentuale
Dalla randomizzazione (mese 0) a 2 anni (24 mesi).
Variazione dell'eGFR (CKD-EPI))
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
mL/min/1,73 m^2
Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Tasso annuo di variazione dell'eGFR (CKD-EPI) (pendenza eGFR totale)
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
ml/min/1,73 m^2/anno
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Variazione della proteina C-reattiva ad alta sensibilità (hs-CRP)
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi
Percentuale
Dalla randomizzazione (mese 0) a 2 anni (24 mesi
Modifica del peptide natriuretico N-terminale-pro-cervello (NT-pro-BNP)
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Percentuale
Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Variazione della frazione di eiezione ventricolare sinistra (LVEF)
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Percentuale
Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Numero di eventi di fibrillazione atriale
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Contare
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Numero di ricoveri con infezione come causa primaria o morte per infezione.
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Contare
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Modifica del punteggio dei componenti fisici (PCS) in forma abbreviata 36 (SF-36)
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Punteggio su scala
Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Tempo alla prima occorrenza di MACE espanso, un endpoint composito costituito da: morte CV, infarto del miocardio non fatale, ictus non fatale e ospedalizzazione per angina pectoris instabile che richiede una rivascolarizzazione coronarica urgente
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Numero di ricoveri per insufficienza cardiaca o visite urgenti per insufficienza cardiaca o decessi CV
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Contare
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Alterazione dell'emoglobina
Lasso di tempo: Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Grammi per decilitro (g/dL)
Dalla randomizzazione (mese 0) a 2 anni (24 mesi)
Tempo alla prima insorgenza di un endpoint renale composito costituito da: morte cardiovascolare, insorgenza di una riduzione persistente di almeno il 40% (%) dell'eGFR (collaborazione CKD-epidemiologia [CKD-EPI]) rispetto al basale, insufficienza renale
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Tempo al verificarsi della mortalità per tutte le cause
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi)
Tempo alla prima occorrenza di un endpoint MACE composito costituito da: mortalità per tutte le cause, infarto miocardico non fatale e ictus non fatale
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Tempo alla prima occorrenza di un endpoint renale a 4 componenti costituito da: insorgenza di una riduzione persistente di almeno il 40% dell'eGFR (CKD-EPI) rispetto al basale, insufficienza renale
Lasso di tempo: Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).
Mesi
Dalla randomizzazione (mese 0) alla fine dello studio (fino a 48 mesi).

Collaboratori e investigatori

Qui è dove troverai le persone e le organizzazioni coinvolte in questo studio.

Sponsor

Novo Nordisk A/S

Investigatori

  • Direttore dello studio: Clinical Transparency (dept. 2834), Novo Nordisk A/S

Pubblicazioni e link utili

La persona responsabile dell'inserimento delle informazioni sullo studio fornisce volontariamente queste pubblicazioni. Questi possono riguardare qualsiasi cosa relativa allo studio.

Pubblicazioni generali

Studiare le date dei record

Queste date tengono traccia dell'avanzamento della registrazione dello studio e dell'invio dei risultati di sintesi a ClinicalTrials.gov. I record degli studi e i risultati riportati vengono esaminati dalla National Library of Medicine (NLM) per assicurarsi che soddisfino specifici standard di controllo della qualità prima di essere pubblicati sul sito Web pubblico.

Studia le date principali

Inizio studio (Effettivo)

30 agosto 2021

Completamento primario (Stimato)

9 giugno 2026

Completamento dello studio (Stimato)

9 giugno 2026

Date di iscrizione allo studio

Primo inviato

19 agosto 2021

Primo inviato che soddisfa i criteri di controllo qualità

19 agosto 2021

Primo Inserito (Effettivo)

26 agosto 2021

Aggiornamenti dei record di studio

Ultimo aggiornamento pubblicato (Effettivo)

13 aprile 2026

Ultimo aggiornamento inviato che soddisfa i criteri QC

7 aprile 2026

Ultimo verificato

1 aprile 2026

Maggiori informazioni

Termini relativi a questo studio

Termini MeSH pertinenti aggiuntivi

Altri numeri di identificazione dello studio

  • EX6018-4758
  • U1111-1259-3422 (Altro identificatore: World Health Organization (WHO))
  • jRCT2021210033 (Identificatore di registro: JAPIC)
  • 2023-506926-35 (Altro identificatore: European Medical Agency (EMA))

Piano per i dati dei singoli partecipanti (IPD)

Hai intenzione di condividere i dati dei singoli partecipanti (IPD)?

SÌ

Descrizione del piano IPD

Secondo l'impegno di divulgazione di Novo Nordisk su novonordisk-trials.com

Informazioni su farmaci e dispositivi, documenti di studio

Studia un prodotto farmaceutico regolamentato dalla FDA degli Stati Uniti

Sì

Studia un dispositivo regolamentato dalla FDA degli Stati Uniti

No

prodotto fabbricato ed esportato dagli Stati Uniti

No

Queste informazioni sono state recuperate direttamente dal sito web clinicaltrials.gov senza alcuna modifica. In caso di richieste di modifica, rimozione o aggiornamento dei dettagli dello studio, contattare register@clinicaltrials.gov. Non appena verrà implementata una modifica su clinicaltrials.gov, questa verrà aggiornata automaticamente anche sul nostro sito web .

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Sponsor e collaboratori

Condizioni mediche

Interventi farmacologici

CROs by country

CROs in Cote d'Ivoire

Condizioni

Malattie rare

Interventi farmacologici

Supplementi dietetici

Sponsor / Collaboratori

Sedi

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