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Afprøvning af tilføjelse af stereootaktisk strålebehandling med immunterapi til behandling af patienter med inoperabel eller metastatisk nyrecellekræft, SAMURAI-undersøgelse (SAMURAI)

21. oktober 2026 opdateret af: NRG Oncology

Randomiseret fase II stereotaktisk ablativ strålebehandling (SABR) til metastatisk uresektioneret nyrecellekarcinom (RCC), der modtager immunterapi (SAMURAI)

This phase II trial tests whether the addition of radiation to the primary tumor, typically given with stereotactic ablative radiation therapy (SABR), in combination with standard of care immunotherapy improves outcomes in patients with renal cell cancer that is not recommended for surgery and has spread from where it first started (primary site) to other places in the body (metastatic). Radiation therapy uses high energy photons to kill tumor cells and shrink tumors. Stereotactic body radiation therapy uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses of radiation over a shorter period and cause less damage to normal tissue. Immunotherapy with monoclonal antibodies, such as nivolumab, ipilimumab, avelumab, and pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Axitinib, cabozantinib, and lenvatinib are in a class of medications called antiangiogenic agents. They work by stopping the formation of blood vessels that bring oxygen and nutrients to tumor. This may slow the growth and spread of tumor. Giving SABR in combination with standard of care immunotherapy may help shrink or stabilize the cancer in patients with renal cell cancer.

Studieoversigt

Detaljeret beskrivelse

PRIMARY OBJECTIVE:

I. To determine whether the addition of stereotactic ablative radiotherapy (SABR) to the primary tumor in combination with immunotherapy improves outcomes compared to immunotherapy alone in patients with metastatic, unresected, renal cell carcinoma (RCC). The primary endpoint is nephrectomy and radiographic progression-free survival (nrPFS) with progression determined as per iRECIST criteria.

SECONDARY OBJECTIVES:

I. To assess the safety, toxicity and tolerability of the two treatment strategies as defined by Common Terminology Criteria for Adverse Events (CTCAE) version 5 in each treatment arm.

II. To assess the objective response rate (ORR) by Immune-related Response Evaluation Criteria in Solid Tumors (iRECIST) in each treatment arm.

III. Nephrectomy and radiographic progression-free survival excluding nephrectomies that were performed for non-protocol specified indications (nephrectomy and radiographic progression-free survival [nrPFS]2).

IV. Radiographic progression-free survival (rPFS). V. To assess overall survival (OS) in each treatment arm. VI. To assess the time to subsequent second-line therapy or death in each treatment arm.

VII. To assess the rate of cytoreductive nephrectomy in each treatment arm. VIII. To assess treatment-free survival in patients who discontinue therapy for reason other than radiographic disease progression.

IX. To assess the ORR by Response Evaluation Criteria in Solid Tumors (RECIST) version 1.1 and iRECIST in the primary renal mass.

EXPLORATORY OBJECTIVES:

I. To assess composite nrPFS in the predefined histological subgroups below:

Ia. Clear cell versus non-clear cell histology; Ib. International Metastatic RCC database consortium (IMDC) intermediate versus poor risk group; Ic. Systemic treatment with immunotherapy-immunotherapy combination versus immunotherapy-vascular endothelial growth factor (VEGF) targeted therapy combination; Id. Sarcomatoid versus non sarcomatoid variant. II. To identify prognostic and predictive biomarkers of response to SABR in the context of immunotherapy based treatment via assessment of tissue and blood based biomarkers.

III. To evaluate the abscopal effect of SABR with systemic therapy. IIIa. Compare ORR in non-irradiated target lesions in the control arm patients undergoing immunotherapy alone to the experimental arm undergoing SABR + immunotherapy.

IV. To evaluate the impact of treatment on level of inferior vena cava (IVC) thrombus.

V. To compare accruing center identified iRECIST progression and centrally identified iRECIST progression events on computed tomography (CT).

OUTLINE: Patients are randomized to 1 of 2 arms. Patients are randomized in a 2:1 ratio favoring the SABR arm.

ARM I: Patients receive one of the following immunotherapy regimens per physician discretion: nivolumab intravenously (IV) over 30 minutes and ipilimumab IV over 30 minutes every 3 weeks for 4 doses followed by nivolumab IV over 30 minutes every 2 or 4 weeks; pembrolizumab IV over 30 minutes every 3 or 6 weeks and axitinib orally (PO) twice daily (BID); avelumab IV over 60 minutes every 2 weeks and axitinib PO BID; nivolumab IV over 30 minutes every 2 or 4 weeks and cabozantinib PO once daily (QD); OR pembrolizumab IV over 30 minutes every 3 or 6 weeks and lenvatinib PO QD. Treatment with immunotherapy continues in the absence of disease progression or unacceptable toxicity. Patients also undergo computed tomography (CT) scan or magnetic resonance imaging (MRI) throughout the trial. Patients may also undergo a bone scan as clinically indicated and blood sample collection throughout the trial.

ARM II: Patients undergo SABR on 3 different days over 1-3 weeks and receive immunotherapy as in Arm I. Patients also undergo CT scan or MRI throughout the trial. Patients may also undergo a bone scan as clinically indicated and blood sample collection throughout the trial.

After completion of study treatment, patients are followed up every 6 months for 5 years, and then annually for 3 years.

Undersøgelsestype

Interventionel

Tilmelding (Anslået)

240

Fase

  • Fase 2

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

    • Victoria
      • Melbourne, Victoria, Australien, 3000
        • Suspenderet
        • Peter MacCallum Cancer Centre
    • Ontario
      • Toronto, Ontario, Canada, M5G 2M9
        • Suspenderet
        • University Health Network-Princess Margaret Hospital
    • Quebec
      • Québec, Quebec, Canada, G1R 2J6
        • Suspenderet
        • CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ)
    • Alabama
      • Birmingham, Alabama, Forenede Stater, 35233
        • Aktiv, ikke rekrutterende
        • University of Alabama at Birmingham Cancer Center
    • Arizona
      • Kingman, Arizona, Forenede Stater, 86401
        • Suspenderet
        • Kingman Regional Medical Center
      • Phoenix, Arizona, Forenede Stater, 85054
        • Rekruttering
        • Mayo Clinic Hospital in Arizona
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
        • Ledende efterforsker:
          • Mark Waddle
    • Arkansas
      • Fayetteville, Arkansas, Forenede Stater, 72703
        • Rekruttering
        • Highlands Oncology Group - Fayetteville
        • Ledende efterforsker:
          • Joseph T. Beck
        • Kontakt:
      • Little Rock, Arkansas, Forenede Stater, 72205
        • Rekruttering
        • University of Arkansas for Medical Sciences
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 501-686-8274
        • Ledende efterforsker:
          • Sanjay Maraboyina
      • Rogers, Arkansas, Forenede Stater, 72758
        • Rekruttering
        • Highlands Oncology Group - Rogers
        • Ledende efterforsker:
          • Joseph T. Beck
        • Kontakt:
      • Springdale, Arkansas, Forenede Stater, 72762
        • Rekruttering
        • Highlands Oncology Group
        • Ledende efterforsker:
          • Joseph T. Beck
        • Kontakt:
    • California
      • Arroyo Grande, California, Forenede Stater, 93420
        • Suspenderet
        • PCR Oncology
      • Beverly Hills, California, Forenede Stater, 90211
      • Burlingame, California, Forenede Stater, 94010
      • Duarte, California, Forenede Stater, 91010
        • Aktiv, ikke rekrutterende
        • City of Hope Comprehensive Cancer Center
      • Encinitas, California, Forenede Stater, 92024
        • Rekruttering
        • UC San Diego Health System - Encinitas
        • Ledende efterforsker:
          • Tyler M. Seibert
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 760-536-7700
      • Irvine, California, Forenede Stater, 92612
        • Rekruttering
        • UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
        • Kontakt:
        • Ledende efterforsker:
          • Shera Feinstein
      • La Jolla, California, Forenede Stater, 92093
        • Rekruttering
        • UC San Diego Moores Cancer Center
        • Ledende efterforsker:
          • Tyler M. Seibert
        • Kontakt:
      • Los Angeles, California, Forenede Stater, 90048
        • Rekruttering
        • Cedars-Sinai Medical Center
        • Ledende efterforsker:
          • Leslie Ballas
        • Kontakt:
      • Los Angeles, California, Forenede Stater, 90033
        • Rekruttering
        • USC / Norris Comprehensive Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 323-865-0451
        • Ledende efterforsker:
          • Lauren A. Lukas
      • Los Angeles, California, Forenede Stater, 90025
        • Rekruttering
        • The Angeles Clinic and Research Institute - West Los Angeles Office
        • Ledende efterforsker:
          • Leslie Ballas
        • Kontakt:
      • Los Angeles, California, Forenede Stater, 90033
        • Rekruttering
        • Los Angeles General Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Lauren A. Lukas
      • Modesto, California, Forenede Stater, 95355
      • Orange, California, Forenede Stater, 92868
        • Rekruttering
        • UC Irvine Health/Chao Family Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Shera Feinstein
      • Roseville, California, Forenede Stater, 95661
        • Rekruttering
        • Sutter Cancer Centers Radiation Oncology Services-Roseville
        • Ledende efterforsker:
          • Christopher U. Jones
        • Kontakt:
      • Roseville, California, Forenede Stater, 95661
      • Sacramento, California, Forenede Stater, 95816
      • San Diego, California, Forenede Stater, 92103
        • Rekruttering
        • UC San Diego Medical Center - Hillcrest
        • Ledende efterforsker:
          • Tyler M. Seibert
        • Kontakt:
      • San Francisco, California, Forenede Stater, 94158
        • Rekruttering
        • UCSF Medical Center-Mission Bay
        • Ledende efterforsker:
          • Steven N. Seyedin
        • Kontakt:
      • San Luis Obispo, California, Forenede Stater, 93401
        • Aktiv, ikke rekrutterende
        • Pacific Central Coast Health Center-San Luis Obispo
      • San Mateo, California, Forenede Stater, 94401
      • Santa Barbara, California, Forenede Stater, 93105
      • Santa Rosa, California, Forenede Stater, 95403
        • Rekruttering
        • Sutter Pacific Medical Foundation
        • Ledende efterforsker:
          • Christopher U. Jones
        • Kontakt:
    • Colorado
      • Aurora, Colorado, Forenede Stater, 80045
        • Rekruttering
        • UCHealth University of Colorado Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 720-848-0650
        • Ledende efterforsker:
          • Corbin Eule
      • Denver, Colorado, Forenede Stater, 80206
        • Rekruttering
        • UCHealth - Cherry Creek
        • Kontakt:
        • Ledende efterforsker:
          • Corbin Eule
      • Fort Collins, Colorado, Forenede Stater, 80524
        • Rekruttering
        • Poudre Valley Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 970-297-6150
        • Ledende efterforsker:
          • Corbin Eule
      • Fort Collins, Colorado, Forenede Stater, 80528
        • Rekruttering
        • Cancer Care and Hematology-Fort Collins
        • Kontakt:
        • Ledende efterforsker:
          • Corbin Eule
      • Greeley, Colorado, Forenede Stater, 80631
        • Rekruttering
        • UCHealth Greeley Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Corbin Eule
      • Highlands Ranch, Colorado, Forenede Stater, 80129
        • Rekruttering
        • UCHealth Highlands Ranch Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 720-848-0650
        • Ledende efterforsker:
          • Corbin Eule
      • Lone Tree, Colorado, Forenede Stater, 80124
        • Rekruttering
        • UCHealth Lone Tree Health Center
        • Kontakt:
        • Ledende efterforsker:
          • Corbin Eule
      • Loveland, Colorado, Forenede Stater, 80538
        • Rekruttering
        • Medical Center of the Rockies
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 970-203-7083
        • Ledende efterforsker:
          • Corbin Eule
    • Delaware
      • Lewes, Delaware, Forenede Stater, 19958
        • Rekruttering
        • Beebe Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Gregory A. Masters
      • Millville, Delaware, Forenede Stater, 19967
        • Rekruttering
        • Beebe South Coastal Health Campus
        • Kontakt:
        • Ledende efterforsker:
          • Gregory A. Masters
      • Newark, Delaware, Forenede Stater, 19713
        • Rekruttering
        • Helen F Graham Cancer Center
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
      • Newark, Delaware, Forenede Stater, 19713
        • Rekruttering
        • Medical Oncology Hematology Consultants PA
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
      • Newark, Delaware, Forenede Stater, 19718
        • Rekruttering
        • Christiana Care Health System-Christiana Hospital
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
      • Rehoboth Beach, Delaware, Forenede Stater, 19971
        • Rekruttering
        • Beebe Health Campus
        • Kontakt:
        • Ledende efterforsker:
          • Gregory A. Masters
      • Wilmington, Delaware, Forenede Stater, 19801
        • Rekruttering
        • Christiana Care Health System-Wilmington Hospital
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
    • Florida
      • Aventura, Florida, Forenede Stater, 33180
        • Rekruttering
        • Mount Sinai Comprehensive Cancer Center at Aventura
        • Kontakt:
        • Ledende efterforsker:
          • Debra L. Linzer
      • Hollywood, Florida, Forenede Stater, 33021
        • Rekruttering
        • Memorial Regional Hospital/Joe DiMaggio Children's Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 954-265-1847
          • E-mail: OHR@mhs.net
        • Ledende efterforsker:
          • Brian A. Pico
      • Jacksonville, Florida, Forenede Stater, 32224-9980
        • Rekruttering
        • Mayo Clinic in Florida
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
        • Ledende efterforsker:
          • Mark Waddle
      • Land O' Lakes, Florida, Forenede Stater, 34638
        • Rekruttering
        • Moffitt Cancer Center at Speros
        • Kontakt:
        • Ledende efterforsker:
          • Kareem Rayn
      • Miami, Florida, Forenede Stater, 33176
        • Rekruttering
        • Miami Cancer Institute
        • Ledende efterforsker:
          • Adeel Kaiser
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 786-596-2000
      • Miami Beach, Florida, Forenede Stater, 33140
        • Rekruttering
        • Mount Sinai Medical Center
        • Ledende efterforsker:
          • Debra L. Linzer
        • Kontakt:
      • Pembroke Pines, Florida, Forenede Stater, 33028
        • Rekruttering
        • Memorial Hospital West
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 954-265-4325
        • Ledende efterforsker:
          • Brian A. Pico
      • Ruskin, Florida, Forenede Stater, 33570
        • Rekruttering
        • Moffitt Cancer Center at SouthShore
        • Kontakt:
        • Ledende efterforsker:
          • Kareem Rayn
      • Tampa, Florida, Forenede Stater, 33607
        • Rekruttering
        • Moffitt Cancer Center-International Plaza
        • Kontakt:
        • Ledende efterforsker:
          • Kareem Rayn
      • Tampa, Florida, Forenede Stater, 33612
        • Rekruttering
        • Moffitt Cancer Center - McKinley Campus
        • Kontakt:
        • Ledende efterforsker:
          • Kareem Rayn
      • Tampa, Florida, Forenede Stater, 33612
        • Rekruttering
        • Moffitt Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Kareem Rayn
      • Wesley Chapel, Florida, Forenede Stater, 33544
        • Rekruttering
        • Moffitt Cancer Center at Wesley Chapel
        • Kontakt:
        • Ledende efterforsker:
          • Kareem Rayn
    • Idaho
      • Boise, Idaho, Forenede Stater, 83706
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Boise
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Caldwell, Idaho, Forenede Stater, 83605
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Caldwell
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Nampa, Idaho, Forenede Stater, 83687
        • Rekruttering
        • Saint Alphonsus Cancer Care Center-Nampa
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
    • Illinois
      • Alton, Illinois, Forenede Stater, 62002
        • Rekruttering
        • Alton Memorial Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 618-463-7323
        • Ledende efterforsker:
          • Hiram A. Gay
      • Centralia, Illinois, Forenede Stater, 62801
        • Rekruttering
        • Centralia Oncology Clinic
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Chicago, Illinois, Forenede Stater, 60637
        • Rekruttering
        • University of Chicago Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Stanley L. Liauw
      • Chicago, Illinois, Forenede Stater, 60611
        • Rekruttering
        • Northwestern University
        • Kontakt:
        • Ledende efterforsker:
          • Sean Sachdev
      • Chicago, Illinois, Forenede Stater, 60641
      • Danville, Illinois, Forenede Stater, 61832
        • Rekruttering
        • Carle at The Riverfront
        • Ledende efterforsker:
          • Daniel H. Barnett
        • Kontakt:
      • DeKalb, Illinois, Forenede Stater, 60115
        • Rekruttering
        • Northwestern Medicine Cancer Center Kishwaukee
        • Kontakt:
        • Ledende efterforsker:
          • Sean Sachdev
      • Decatur, Illinois, Forenede Stater, 62526
        • Rekruttering
        • Cancer Care Specialists of Illinois - Decatur
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Decatur, Illinois, Forenede Stater, 62526
        • Rekruttering
        • Decatur Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Effingham, Illinois, Forenede Stater, 62401
        • Rekruttering
        • Carle Physician Group-Effingham
        • Ledende efterforsker:
          • Daniel H. Barnett
        • Kontakt:
      • Effingham, Illinois, Forenede Stater, 62401
        • Rekruttering
        • Crossroads Cancer Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Geneva, Illinois, Forenede Stater, 60134
        • Rekruttering
        • Northwestern Medicine Cancer Center Delnor
        • Kontakt:
        • Ledende efterforsker:
          • Sean Sachdev
      • Glenview, Illinois, Forenede Stater, 60026
        • Rekruttering
        • Northwestern Medicine Glenview Outpatient Center
        • Ledende efterforsker:
          • Sean Sachdev
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-695-1102
      • Grayslake, Illinois, Forenede Stater, 60030
        • Rekruttering
        • Northwestern Medicine Grayslake Outpatient Center
        • Ledende efterforsker:
          • Sean Sachdev
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 312-695-1102
      • Harvey, Illinois, Forenede Stater, 60426
        • Rekruttering
        • Ingalls Memorial Hospital
        • Ledende efterforsker:
          • James A. Wallace
        • Kontakt:
      • Lake Forest, Illinois, Forenede Stater, 60045
        • Rekruttering
        • Northwestern Medicine Lake Forest Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Sean Sachdev
      • Mattoon, Illinois, Forenede Stater, 61938
        • Rekruttering
        • Carle Physician Group-Mattoon/Charleston
        • Ledende efterforsker:
          • Daniel H. Barnett
        • Kontakt:
      • New Lenox, Illinois, Forenede Stater, 60451
        • Rekruttering
        • UC Comprehensive Cancer Center at Silver Cross
        • Kontakt:
        • Ledende efterforsker:
          • Stanley L. Liauw
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Rekruttering
        • Cancer Care Center of O'Fallon
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • O'Fallon, Illinois, Forenede Stater, 62269
        • Rekruttering
        • HSHS Saint Elizabeth's Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Oak Brook, Illinois, Forenede Stater, 60523
      • Orland Park, Illinois, Forenede Stater, 60462
        • Rekruttering
        • University of Chicago Medicine-Orland Park
        • Kontakt:
        • Ledende efterforsker:
          • Stanley L. Liauw
      • Orland Park, Illinois, Forenede Stater, 60462
      • Rockford, Illinois, Forenede Stater, 61114
        • Rekruttering
        • UW Health Carbone Cancer Center Rockford
        • Kontakt:
        • Ledende efterforsker:
          • Fahrettin Covut
      • Shiloh, Illinois, Forenede Stater, 62269
        • Rekruttering
        • Memorial Hospital East
        • Kontakt:
        • Ledende efterforsker:
          • Hiram A. Gay
      • Springfield, Illinois, Forenede Stater, 62702
        • Rekruttering
        • Southern Illinois University School of Medicine
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 217-545-7929
      • Springfield, Illinois, Forenede Stater, 62702
        • Rekruttering
        • Springfield Clinic
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-444-7541
      • Springfield, Illinois, Forenede Stater, 62781
        • Rekruttering
        • Springfield Memorial Hospital
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
      • Urbana, Illinois, Forenede Stater, 61801
        • Rekruttering
        • Carle Cancer Center
        • Ledende efterforsker:
          • Daniel H. Barnett
        • Kontakt:
      • Urbana, Illinois, Forenede Stater, 61801
        • Rekruttering
        • The Carle Foundation Hospital
        • Ledende efterforsker:
          • Daniel H. Barnett
        • Kontakt:
      • Warrenville, Illinois, Forenede Stater, 60555
        • Rekruttering
        • Northwestern Medicine Cancer Center Warrenville
        • Kontakt:
        • Ledende efterforsker:
          • Sean Sachdev
    • Indiana
      • Crown Point, Indiana, Forenede Stater, 46307
        • Rekruttering
        • UChicago Medicine Northwest Indiana
        • Ledende efterforsker:
          • Stanley L. Liauw
        • Kontakt:
      • Indianapolis, Indiana, Forenede Stater, 46237
        • Rekruttering
        • Franciscan Health Indianapolis
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 317-528-7060
        • Ledende efterforsker:
          • Craig Schneider
      • Mooresville, Indiana, Forenede Stater, 46158
        • Rekruttering
        • Franciscan Health Mooresville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 317-834-3603
        • Ledende efterforsker:
          • Craig Schneider
    • Iowa
      • Ames, Iowa, Forenede Stater, 50010
        • Rekruttering
        • Mary Greeley Medical Center
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-956-4132
      • Ames, Iowa, Forenede Stater, 50010
        • Rekruttering
        • McFarland Clinic - Ames
        • Ledende efterforsker:
          • Joseph J. Merchant
        • Kontakt:
      • Ankeny, Iowa, Forenede Stater, 50023
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Ankeny Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Clive, Iowa, Forenede Stater, 50325
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - West Des Moines Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50309
        • Rekruttering
        • Iowa Methodist Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-6727
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50309
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Des Moines Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Des Moines, Iowa, Forenede Stater, 50314
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Laurel Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
      • Waukee, Iowa, Forenede Stater, 50263
        • Rekruttering
        • UI Health Care Mission Cancer and Blood - Waukee Clinic
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 515-241-3305
        • Ledende efterforsker:
          • Seema Harichand-Herdt
    • Louisiana
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Rekruttering
        • Louisiana Hematology Oncology Associates LLC
        • Kontakt:
        • Ledende efterforsker:
          • Victor T. Lin
      • Baton Rouge, Louisiana, Forenede Stater, 70809
        • Rekruttering
        • Mary Bird Perkins Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Victor T. Lin
      • Metairie, Louisiana, Forenede Stater, 70006
        • Aktiv, ikke rekrutterende
        • East Jefferson General Hospital
      • Metairie, Louisiana, Forenede Stater, 70006
        • Aktiv, ikke rekrutterende
        • LSU Healthcare Network / Metairie Multi-Specialty Clinic
      • Metairie, Louisiana, Forenede Stater, 70002
        • Rekruttering
        • Mary Bird Perkins Cancer Center - Metairie
        • Ledende efterforsker:
          • Victor T. Lin
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 504-584-6990
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Aktiv, ikke rekrutterende
        • Louisiana State University Health Science Center
      • New Orleans, Louisiana, Forenede Stater, 70112
        • Aktiv, ikke rekrutterende
        • University Medical Center New Orleans
      • New Orleans, Louisiana, Forenede Stater, 70115
        • Aktiv, ikke rekrutterende
        • Touro Infirmary
    • Maine
      • Bath, Maine, Forenede Stater, 04530
        • Aktiv, ikke rekrutterende
        • MaineHealth Coastal Cancer Treatment Center
      • Biddeford, Maine, Forenede Stater, 04005
        • Aktiv, ikke rekrutterende
        • MaineHealth Maine Medical Center - Biddeford
      • Portland, Maine, Forenede Stater, 04102
        • Aktiv, ikke rekrutterende
        • MaineHealth Maine Medical Center - Portland
      • Sanford, Maine, Forenede Stater, 04073
        • Aktiv, ikke rekrutterende
        • MaineHealth Cancer Care Center of York County
      • Sanford, Maine, Forenede Stater, 04073
        • Aktiv, ikke rekrutterende
        • MaineHealth Cancer Care and IV Therapy - Sanford
      • Scarborough, Maine, Forenede Stater, 04074
        • Aktiv, ikke rekrutterende
        • MaineHealth Maine Medical Center- Scarborough
      • South Portland, Maine, Forenede Stater, 04106
        • Aktiv, ikke rekrutterende
        • MaineHealth Cancer Care and IV Therapy - South Portland
    • Maryland
      • Baltimore, Maryland, Forenede Stater, 21201
        • Aktiv, ikke rekrutterende
        • University of Maryland/Greenebaum Cancer Center
      • Columbia, Maryland, Forenede Stater, 21044
        • Aktiv, ikke rekrutterende
        • Central Maryland Radiation Oncology in Howard County
      • Glen Burnie, Maryland, Forenede Stater, 21061
        • Aktiv, ikke rekrutterende
        • UM Baltimore Washington Medical Center/Tate Cancer Center
    • Massachusetts
      • Beverly, Massachusetts, Forenede Stater, 01915
        • Aktiv, ikke rekrutterende
        • Beverly Hospital
      • Boston, Massachusetts, Forenede Stater, 02115
        • Rekruttering
        • Brigham and Women's Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 617-724-5200
        • Ledende efterforsker:
          • Bradley A. McGregor
      • Boston, Massachusetts, Forenede Stater, 02114
        • Rekruttering
        • Massachusetts General Hospital Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-726-5130
        • Ledende efterforsker:
          • Sophia C. Kamran
      • Boston, Massachusetts, Forenede Stater, 02215
        • Rekruttering
        • Dana-Farber Cancer Institute
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-442-3324
        • Ledende efterforsker:
          • Bradley A. McGregor
      • Burlington, Massachusetts, Forenede Stater, 01805
        • Aktiv, ikke rekrutterende
        • Lahey Clinic
      • Gloucester, Massachusetts, Forenede Stater, 01930
        • Aktiv, ikke rekrutterende
        • Addison Gilbert Hospital
      • Peabody, Massachusetts, Forenede Stater, 01960
        • Aktiv, ikke rekrutterende
        • Lahey Clinic Peabody
      • Winchester, Massachusetts, Forenede Stater, 01890
        • Aktiv, ikke rekrutterende
        • Beth Israel Deaconess Medical Center/Winchester Center for Cancer Care
    • Michigan
      • Ann Arbor, Michigan, Forenede Stater, 48109
        • Rekruttering
        • University of Michigan Rogel Cancer Center
        • Ledende efterforsker:
          • William C. Jackson
        • Kontakt:
      • Ann Arbor, Michigan, Forenede Stater, 48106
        • Rekruttering
        • Trinity Health Saint Joseph Mercy Hospital Ann Arbor
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Brighton, Michigan, Forenede Stater, 48114
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Brighton
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Brighton, Michigan, Forenede Stater, 48114
        • Rekruttering
        • Trinity Health Medical Center - Brighton
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Canton, Michigan, Forenede Stater, 48188
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Canton
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Canton, Michigan, Forenede Stater, 48188
      • Chelsea, Michigan, Forenede Stater, 48118
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Chelsea, Michigan, Forenede Stater, 48118
      • Dearborn, Michigan, Forenede Stater, 48124
        • Rekruttering
        • Corewell Health Dearborn Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 248-551-7695
        • Ledende efterforsker:
          • Daniel J. Krauss
      • Farmington Hills, Michigan, Forenede Stater, 48336
        • Suspenderet
        • Corewell Health Farmington Hills Hospital
      • Lansing, Michigan, Forenede Stater, 48912
        • Rekruttering
        • University of Michigan Health - Sparrow Lansing
        • Ledende efterforsker:
          • Samir Narayan
        • Kontakt:
      • Livonia, Michigan, Forenede Stater, 48154
        • Rekruttering
        • Trinity Health Saint Mary Mercy Livonia Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Royal Oak, Michigan, Forenede Stater, 48073
        • Rekruttering
        • Corewell Health William Beaumont University Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 248-551-7695
        • Ledende efterforsker:
          • Daniel J. Krauss
      • Troy, Michigan, Forenede Stater, 48085
        • Rekruttering
        • Corewell Health Beaumont Troy Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 248-551-7695
        • Ledende efterforsker:
          • Daniel J. Krauss
      • Ypsilanti, Michigan, Forenede Stater, 48197
        • Rekruttering
        • Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
    • Minnesota
      • Bemidji, Minnesota, Forenede Stater, 56601
      • Brainerd, Minnesota, Forenede Stater, 56401
        • Rekruttering
        • Essentia Health Saint Joseph's Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Chaska, Minnesota, Forenede Stater, 55318
        • Rekruttering
        • Minnesota Oncology Hematology PA-Chaska
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Coon Rapids, Minnesota, Forenede Stater, 55433
        • Rekruttering
        • Mercy Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Deer River, Minnesota, Forenede Stater, 56636
        • Rekruttering
        • Essentia Health - Deer River Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Duluth, Minnesota, Forenede Stater, 55805
        • Rekruttering
        • Essentia Health Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Duluth, Minnesota, Forenede Stater, 55805
        • Rekruttering
        • Essentia Health Saint Mary's Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Duluth, Minnesota, Forenede Stater, 55805
        • Rekruttering
        • Miller-Dwan Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Edina, Minnesota, Forenede Stater, 55435
        • Rekruttering
        • Fairview Southdale Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Hibbing, Minnesota, Forenede Stater, 55746
        • Rekruttering
        • Essentia Health Hibbing Clinic
        • Ledende efterforsker:
          • Bret E. Friday
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 218-786-3308
      • Maple Grove, Minnesota, Forenede Stater, 55369
        • Rekruttering
        • Fairview Clinics and Surgery Center Maple Grove
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Minneapolis, Minnesota, Forenede Stater, 55407
        • Rekruttering
        • Abbott-Northwestern Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Minneapolis, Minnesota, Forenede Stater, 55415
        • Rekruttering
        • Hennepin County Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Minneapolis, Minnesota, Forenede Stater, 55455
        • Rekruttering
        • University of Minnesota/Masonic Cancer Center
        • Ledende efterforsker:
          • Ian J. Okazaki
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 612-624-2620
      • Rochester, Minnesota, Forenede Stater, 55905
        • Rekruttering
        • Mayo Clinic in Rochester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 855-776-0015
        • Ledende efterforsker:
          • Mark Waddle
      • Saint Louis Park, Minnesota, Forenede Stater, 55416
        • Rekruttering
        • Park Nicollet Clinic - Saint Louis Park
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Saint Paul, Minnesota, Forenede Stater, 55101
        • Rekruttering
        • Regions Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Sandstone, Minnesota, Forenede Stater, 55072
        • Rekruttering
        • Essentia Health Sandstone
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Shakopee, Minnesota, Forenede Stater, 55379
        • Rekruttering
        • Saint Francis Regional Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Stillwater, Minnesota, Forenede Stater, 55082
        • Rekruttering
        • Lakeview Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Virginia, Minnesota, Forenede Stater, 55792
        • Rekruttering
        • Essentia Health Virginia Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Waconia, Minnesota, Forenede Stater, 55387
        • Rekruttering
        • Ridgeview Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
    • Missouri
      • Cape Girardeau, Missouri, Forenede Stater, 63703
        • Rekruttering
        • Saint Francis Medical Center
        • Ledende efterforsker:
          • Bryan A. Faller
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 573-334-2230
          • E-mail: sfmc@sfmc.net
      • City of Saint Peters, Missouri, Forenede Stater, 63376
        • Rekruttering
        • Siteman Cancer Center at Saint Peters Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Hiram A. Gay
      • Columbia, Missouri, Forenede Stater, 65212
        • Rekruttering
        • MU Health - University Hospital/Ellis Fischel Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 573-882-7440
        • Ledende efterforsker:
          • Gregory B. Biedermann
      • Creve Coeur, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Siteman Cancer Center at West County Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Hiram A. Gay
      • Springfield, Missouri, Forenede Stater, 65804
        • Rekruttering
        • Mercy Hospital Springfield
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 417-269-4520
      • St Louis, Missouri, Forenede Stater, 63110
        • Rekruttering
        • Washington University School of Medicine
        • Kontakt:
        • Ledende efterforsker:
          • Hiram A. Gay
      • St Louis, Missouri, Forenede Stater, 63128
        • Rekruttering
        • Mercy Hospital South
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
      • St Louis, Missouri, Forenede Stater, 63141
        • Rekruttering
        • Mercy Hospital Saint Louis
        • Ledende efterforsker:
          • Jay W. Carlson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 314-251-7066
      • St Louis, Missouri, Forenede Stater, 63129
        • Rekruttering
        • Siteman Cancer Center-South County
        • Kontakt:
        • Ledende efterforsker:
          • Hiram A. Gay
      • St Louis, Missouri, Forenede Stater, 63136
        • Rekruttering
        • Siteman Cancer Center at Christian Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Hiram A. Gay
    • Nebraska
      • Bellevue, Nebraska, Forenede Stater, 68123
        • Rekruttering
        • Nebraska Medicine-Bellevue
        • Kontakt:
        • Ledende efterforsker:
          • Harshraj Leuva
      • Omaha, Nebraska, Forenede Stater, 68198
        • Rekruttering
        • University of Nebraska Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Harshraj Leuva
      • Omaha, Nebraska, Forenede Stater, 68118
        • Rekruttering
        • Nebraska Medicine-Village Pointe
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 402-559-5600
        • Ledende efterforsker:
          • Harshraj Leuva
    • Nevada
      • Reno, Nevada, Forenede Stater, 89502
        • Rekruttering
        • Renown Regional Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Suchit H. Patel
    • New Jersey
      • Basking Ridge, New Jersey, Forenede Stater, 07920
        • Rekruttering
        • Memorial Sloan Kettering Basking Ridge
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
      • Camden, New Jersey, Forenede Stater, 08103
        • Rekruttering
        • Cooper Hospital University Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 856-325-6757
        • Ledende efterforsker:
          • Gary Eastwick
      • Lakewood, New Jersey, Forenede Stater, 08701
        • Aktiv, ikke rekrutterende
        • Monmouth Medical Center Southern Campus
      • Long Branch, New Jersey, Forenede Stater, 07740
        • Aktiv, ikke rekrutterende
        • Monmouth Medical Center
      • Middletown, New Jersey, Forenede Stater, 07748
        • Rekruttering
        • Memorial Sloan Kettering Monmouth
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
      • Montvale, New Jersey, Forenede Stater, 07645
        • Rekruttering
        • Memorial Sloan Kettering Bergen
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
      • Mount Laurel, New Jersey, Forenede Stater, 08054
        • Rekruttering
        • Cooper CyberKnife Center
        • Ledende efterforsker:
          • Gary Eastwick
        • Kontakt:
      • New Brunswick, New Jersey, Forenede Stater, 08903
        • Aktiv, ikke rekrutterende
        • Rutgers Cancer Institute of New Jersey
      • Newark, New Jersey, Forenede Stater, 07101
        • Aktiv, ikke rekrutterende
        • Rutgers New Jersey Medical School
      • Toms River, New Jersey, Forenede Stater, 08755
        • Aktiv, ikke rekrutterende
        • Community Medical Center
    • New Mexico
      • Albuquerque, New Mexico, Forenede Stater, 87102
        • Rekruttering
        • Lovelace Medical Center-Saint Joseph Square
        • Ledende efterforsker:
          • Thomas M. Schroeder
        • Kontakt:
      • Albuquerque, New Mexico, Forenede Stater, 87109
        • Rekruttering
        • Lovelace Radiation Oncology
        • Kontakt:
        • Ledende efterforsker:
          • Thomas M. Schroeder
      • Albuquerque, New Mexico, Forenede Stater, 87106
        • Rekruttering
        • University of New Mexico Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Thomas M. Schroeder
    • New York
      • Bay Shore, New York, Forenede Stater, 11706
        • Rekruttering
        • Northwell Health Imbert Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Clary Evans
      • Commack, New York, Forenede Stater, 11725
        • Rekruttering
        • Memorial Sloan Kettering Commack
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
      • Glens Falls, New York, Forenede Stater, 12801
        • Rekruttering
        • Glens Falls Hospital
        • Ledende efterforsker:
          • Nataniel H. Lester-Coll
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 518-926-6700
      • Greenlawn, New York, Forenede Stater, 11740
        • Rekruttering
        • Northwell Health Cancer Institute at Huntington
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Clary Evans
      • Harrison, New York, Forenede Stater, 10604
        • Rekruttering
        • Memorial Sloan Kettering Westchester
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
      • Lake Success, New York, Forenede Stater, 11042
        • Rekruttering
        • Northwell Health/Center for Advanced Medicine
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Clary Evans
      • Mount Kisco, New York, Forenede Stater, 10549
        • Rekruttering
        • Northern Westchester Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Clary Evans
      • New York, New York, Forenede Stater, 10065
        • Rekruttering
        • Memorial Sloan Kettering Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
      • New York, New York, Forenede Stater, 10016
        • Rekruttering
        • Laura and Isaac Perlmutter Cancer Center at NYU Langone
        • Ledende efterforsker:
          • Anand Mahadevan
        • Kontakt:
      • New York, New York, Forenede Stater, 10075
        • Rekruttering
        • Lenox Hill Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 516-734-8896
        • Ledende efterforsker:
          • Clary Evans
      • New York, New York, Forenede Stater, 10065
        • Rekruttering
        • Manhattan Eye Ear and Throat Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-434-4460
        • Ledende efterforsker:
          • Clary Evans
      • Sleepy Hollow, New York, Forenede Stater, 10591
        • Rekruttering
        • Phelps Memorial Hospital Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 914-366-1600
        • Ledende efterforsker:
          • Clary Evans
      • Stony Brook, New York, Forenede Stater, 11794
        • Aktiv, ikke rekrutterende
        • Stony Brook University Medical Center
      • Uniondale, New York, Forenede Stater, 11553
        • Rekruttering
        • Memorial Sloan Kettering Nassau
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 212-639-7592
        • Ledende efterforsker:
          • Daniel Gorovets
    • North Carolina
      • Cary, North Carolina, Forenede Stater, 27518
        • Rekruttering
        • Duke Cancer Center Cary
        • Ledende efterforsker:
          • Ryan E. Fecteau
        • Kontakt:
      • Chapel Hill, North Carolina, Forenede Stater, 27599
        • Rekruttering
        • UNC Lineberger Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Tracy L. Rose
      • Charlotte, North Carolina, Forenede Stater, 28203
        • Rekruttering
        • Carolinas Medical Center/Levine Cancer Institute
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
        • Ledende efterforsker:
          • Claud M. Grigg
      • Charlotte, North Carolina, Forenede Stater, 28210
        • Rekruttering
        • Atrium Health Pineville/LCI-Pineville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-2000
        • Ledende efterforsker:
          • Claud M. Grigg
      • Charlotte, North Carolina, Forenede Stater, 28262
        • Rekruttering
        • Atrium Health University City/LCI-University
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
        • Ledende efterforsker:
          • Claud M. Grigg
      • Charlotte, North Carolina, Forenede Stater, 28277
        • Rekruttering
        • Levine Cancer Institute-Ballantyne
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
        • Ledende efterforsker:
          • Claud M. Grigg
      • Clemmons, North Carolina, Forenede Stater, 27012
        • Rekruttering
        • Wake Forest University at Clemmons
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-716-9259
        • Ledende efterforsker:
          • Michael McCormack
      • Concord, North Carolina, Forenede Stater, 28025
        • Rekruttering
        • Atrium Health Cabarrus/LCI-Concord
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
        • Ledende efterforsker:
          • Claud M. Grigg
      • Durham, North Carolina, Forenede Stater, 27710
        • Rekruttering
        • Duke University Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-275-3853
        • Ledende efterforsker:
          • Ryan E. Fecteau
      • Gastonia, North Carolina, Forenede Stater, 28054
        • Rekruttering
        • Levine Cancer Institute-Gaston
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-804-9376
        • Ledende efterforsker:
          • Claud M. Grigg
      • High Point, North Carolina, Forenede Stater, 27262
        • Rekruttering
        • Hayworth Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 336-802-2500
        • Ledende efterforsker:
          • Michael McCormack
      • Monroe, North Carolina, Forenede Stater, 28112
        • Rekruttering
        • Atrium Health Union/LCI-Union
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 980-442-2000
        • Ledende efterforsker:
          • Claud M. Grigg
      • Raleigh, North Carolina, Forenede Stater, 27609
        • Rekruttering
        • Duke Cancer Center Raleigh
        • Ledende efterforsker:
          • Ryan E. Fecteau
        • Kontakt:
      • Statesville, North Carolina, Forenede Stater, 28677
        • Rekruttering
        • Wake Forest Baptist Health - Hematology Oncology - Statesville
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 704-872-3630
        • Ledende efterforsker:
          • Michael McCormack
      • Wilkesboro, North Carolina, Forenede Stater, 28659
        • Rekruttering
        • Wake Forest Baptist Health - Wilkes Medical Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 888-716-9253
        • Ledende efterforsker:
          • Michael McCormack
      • Winston-Salem, North Carolina, Forenede Stater, 27157
        • Rekruttering
        • Wake Forest University Health Sciences
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 336-713-6771
        • Ledende efterforsker:
          • Michael McCormack
    • North Dakota
      • Bismarck, North Dakota, Forenede Stater, 58501
      • Fargo, North Dakota, Forenede Stater, 58122
      • Fargo, North Dakota, Forenede Stater, 58122
    • Ohio
      • Avon, Ohio, Forenede Stater, 44011
        • Rekruttering
        • UH Seidman Cancer Center at UH Avon Health Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 800-641-2422
        • Ledende efterforsker:
          • Pedro Barata
      • Beachwood, Ohio, Forenede Stater, 44122
        • Rekruttering
        • UHHS-Chagrin Highlands Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Pedro Barata
      • Centerville, Ohio, Forenede Stater, 45459
        • Rekruttering
        • Miami Valley Hospital South
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Centerville, Ohio, Forenede Stater, 45459
        • Aktiv, ikke rekrutterende
        • Dayton Physicians LLC-Miami Valley South
      • Cincinnati, Ohio, Forenede Stater, 45219
        • Rekruttering
        • University of Cincinnati Cancer Center-UC Medical Center
        • Ledende efterforsker:
          • Timothy D. Struve
        • Kontakt:
      • Cleveland, Ohio, Forenede Stater, 44106
        • Rekruttering
        • Case Western Reserve University
        • Kontakt:
        • Ledende efterforsker:
          • Pedro Barata
      • Columbus, Ohio, Forenede Stater, 43210
        • Rekruttering
        • Ohio State University Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Shang-Jui Wang
      • Dayton, Ohio, Forenede Stater, 45409
        • Rekruttering
        • Miami Valley Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Dayton, Ohio, Forenede Stater, 45415
        • Rekruttering
        • Miami Valley Hospital North
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Dayton, Ohio, Forenede Stater, 45409
        • Rekruttering
        • Premier Blood and Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 937-276-8320
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Dayton, Ohio, Forenede Stater, 45415
        • Aktiv, ikke rekrutterende
        • Dayton Physician LLC - Englewood
      • Franklin, Ohio, Forenede Stater, 45005-1066
        • Rekruttering
        • Atrium Medical Center-Middletown Regional Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • Franklin, Ohio, Forenede Stater, 45005
        • Aktiv, ikke rekrutterende
        • Dayton Physicians LLC-Atrium
      • Greenville, Ohio, Forenede Stater, 45331
        • Rekruttering
        • Miami Valley Cancer Care and Infusion
        • Ledende efterforsker:
          • Tarek M. Sabagh
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 937-569-7515
      • Mentor, Ohio, Forenede Stater, 44060
        • Rekruttering
        • UH Seidman Cancer Center at Lake Health Mentor Campus
        • Kontakt:
        • Ledende efterforsker:
          • Pedro Barata
      • Parma, Ohio, Forenede Stater, 44129
        • Rekruttering
        • University Hospitals Parma Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Pedro Barata
      • Ravenna, Ohio, Forenede Stater, 44266
        • Rekruttering
        • University Hospitals Portage Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Pedro Barata
      • Troy, Ohio, Forenede Stater, 45373
        • Rekruttering
        • Upper Valley Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Tarek M. Sabagh
      • West Chester, Ohio, Forenede Stater, 45069
        • Rekruttering
        • University of Cincinnati Cancer Center-West Chester
        • Ledende efterforsker:
          • Timothy D. Struve
        • Kontakt:
    • Oklahoma
      • Oklahoma City, Oklahoma, Forenede Stater, 73104
        • Rekruttering
        • University of Oklahoma Health Sciences Center
        • Kontakt:
        • Ledende efterforsker:
          • Tyler Gunter
      • Tulsa, Oklahoma, Forenede Stater, 74146
        • Rekruttering
        • Oklahoma Cancer Specialists and Research Institute-Tulsa
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 918-505-3200
        • Ledende efterforsker:
          • Mark B. Jennings
    • Pennsylvania
      • Allentown, Pennsylvania, Forenede Stater, 18103
        • Rekruttering
        • Lehigh Valley Hospital-Cedar Crest
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Beaver, Pennsylvania, Forenede Stater, 15009
        • Rekruttering
        • UPMC-Heritage Valley Health System Beaver
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Bethlehem, Pennsylvania, Forenede Stater, 18017
        • Rekruttering
        • Lehigh Valley Hospital - Muhlenberg
        • Kontakt:
        • Ledende efterforsker:
          • Samir Narayan
      • Carlisle, Pennsylvania, Forenede Stater, 17015
        • Rekruttering
        • Carlisle Regional Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Chadds Ford, Pennsylvania, Forenede Stater, 19317
        • Rekruttering
        • Christiana Care Health System-Concord Health Center
        • Ledende efterforsker:
          • Gregory A. Masters
        • Kontakt:
      • Danville, Pennsylvania, Forenede Stater, 17822
        • Rekruttering
        • Geisinger Medical Center
        • Ledende efterforsker:
          • Fiori Alite
        • Kontakt:
      • Dickson City, Pennsylvania, Forenede Stater, 18519
        • Rekruttering
        • Geisinger Cancer Center Dickson City
        • Ledende efterforsker:
          • Fiori Alite
        • Kontakt:
      • Erie, Pennsylvania, Forenede Stater, 16505
        • Rekruttering
        • UPMC Hillman Cancer Center Erie
        • Ledende efterforsker:
          • Adam Olson
        • Kontakt:
      • Erie, Pennsylvania, Forenede Stater, 16544
        • Rekruttering
        • Saint Vincent Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 814-452-5000
        • Ledende efterforsker:
          • Alexander Helfand
      • Farrell, Pennsylvania, Forenede Stater, 16121
        • Rekruttering
        • UPMC Cancer Center at UPMC Horizon
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Greensburg, Pennsylvania, Forenede Stater, 15601
        • Rekruttering
        • UPMC Cancer Centers - Arnold Palmer Pavilion
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 724-838-1900
        • Ledende efterforsker:
          • Adam Olson
      • Harrisburg, Pennsylvania, Forenede Stater, 17109
        • Rekruttering
        • UPMC Pinnacle Cancer Center/Community Osteopathic Campus
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Hazleton, Pennsylvania, Forenede Stater, 18201
        • Rekruttering
        • Geisinger Medical Center-Cancer Center Hazleton
        • Ledende efterforsker:
          • Fiori Alite
        • Kontakt:
      • Hershey, Pennsylvania, Forenede Stater, 17033-0850
        • Rekruttering
        • Penn State Milton S Hershey Medical Center
        • Ledende efterforsker:
          • Joseph A. Miccio
        • Kontakt:
      • Indiana, Pennsylvania, Forenede Stater, 15701
        • Rekruttering
        • IRMC Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Jefferson Hills, Pennsylvania, Forenede Stater, 15025
        • Rekruttering
        • Jefferson Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Alexander Helfand
      • Lewisburg, Pennsylvania, Forenede Stater, 17837
        • Rekruttering
        • Geisinger Medical Oncology-Lewisburg
        • Ledende efterforsker:
          • Fiori Alite
        • Kontakt:
      • Mechanicsburg, Pennsylvania, Forenede Stater, 17050
        • Rekruttering
        • UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • Rekruttering
        • Forbes Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-858-7746
        • Ledende efterforsker:
          • Alexander Helfand
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • Rekruttering
        • UPMC Hillman Cancer Center - Monroeville
        • Ledende efterforsker:
          • Adam Olson
        • Kontakt:
      • Monroeville, Pennsylvania, Forenede Stater, 15146
        • Rekruttering
        • UPMC Cancer Center - Monroeville
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • New Castle, Pennsylvania, Forenede Stater, 16105
        • Rekruttering
        • UPMC Hillman Cancer Center - New Castle
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Pittsburgh, Pennsylvania, Forenede Stater, 15213
        • Rekruttering
        • UPMC-Magee Womens Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-647-2811
        • Ledende efterforsker:
          • Adam Olson
      • Pittsburgh, Pennsylvania, Forenede Stater, 15224
        • Rekruttering
        • West Penn Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-578-5000
        • Ledende efterforsker:
          • Alexander Helfand
      • Pittsburgh, Pennsylvania, Forenede Stater, 15215
        • Rekruttering
        • UPMC-Saint Margaret
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-784-4900
        • Ledende efterforsker:
          • Adam Olson
      • Pittsburgh, Pennsylvania, Forenede Stater, 15237
        • Rekruttering
        • UPMC-Passavant Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-367-6454
        • Ledende efterforsker:
          • Adam Olson
      • Pittsburgh, Pennsylvania, Forenede Stater, 15243
        • Rekruttering
        • UPMC-Saint Clair Hospital Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-502-3920
        • Ledende efterforsker:
          • Adam Olson
      • Pittsburgh, Pennsylvania, Forenede Stater, 15212
        • Rekruttering
        • Allegheny General Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-284-2000
        • Ledende efterforsker:
          • Alexander Helfand
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • Rekruttering
        • UPMC Hillman Cancer Center
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-647-8073
        • Ledende efterforsker:
          • Adam Olson
      • Pittsburgh, Pennsylvania, Forenede Stater, 15232
        • Rekruttering
        • UPMC-Shadyside Hospital
        • Ledende efterforsker:
          • Adam Olson
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 412-621-2334
      • Pottsville, Pennsylvania, Forenede Stater, 17901
        • Rekruttering
        • Geisinger Cancer Services-Pottsville
        • Ledende efterforsker:
          • Fiori Alite
        • Kontakt:
      • Scranton, Pennsylvania, Forenede Stater, 18510
        • Rekruttering
        • Community Medical Center
        • Ledende efterforsker:
          • Fiori Alite
        • Kontakt:
      • Seneca, Pennsylvania, Forenede Stater, 16346
        • Rekruttering
        • UPMC Cancer Center at UPMC Northwest
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 814-676-7900
        • Ledende efterforsker:
          • Adam Olson
      • Washington, Pennsylvania, Forenede Stater, 15301
        • Rekruttering
        • UPMC Cancer Center-Washington
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • Washington, Pennsylvania, Forenede Stater, 15301
        • Rekruttering
        • UPMC Washington Hospital Radiation Oncology
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • West Reading, Pennsylvania, Forenede Stater, 19611
        • Rekruttering
        • Reading Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 610-988-9323
        • Ledende efterforsker:
          • Michael L. Haas
      • Wexford, Pennsylvania, Forenede Stater, 15090
        • Rekruttering
        • Wexford Health and Wellness Pavilion
        • Kontakt:
        • Ledende efterforsker:
          • Alexander Helfand
      • Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
        • Rekruttering
        • Geisinger Wyoming Valley/Henry Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Fiori Alite
      • Williamsport, Pennsylvania, Forenede Stater, 17754
        • Rekruttering
        • Divine Providence Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Adam Olson
      • York, Pennsylvania, Forenede Stater, 17408
        • Rekruttering
        • UPMC Memorial
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 717-724-6760
        • Ledende efterforsker:
          • Adam Olson
    • South Carolina
      • Charleston, South Carolina, Forenede Stater, 29425
        • Rekruttering
        • Medical University of South Carolina
        • Kontakt:
        • Ledende efterforsker:
          • Harriet B. Eldredge-Hindy
      • Greenwood, South Carolina, Forenede Stater, 29646
        • Rekruttering
        • Self Regional Healthcare
        • Kontakt:
        • Ledende efterforsker:
          • Harriet B. Eldredge-Hindy
    • South Dakota
      • Sioux Falls, South Dakota, Forenede Stater, 57104
      • Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    • Texas
      • Dallas, Texas, Forenede Stater, 75390
        • Rekruttering
        • UT Southwestern/Simmons Cancer Center-Dallas
        • Kontakt:
        • Ledende efterforsker:
          • Raquibul Hannan
      • Dallas, Texas, Forenede Stater, 75235
        • Rekruttering
        • Parkland Memorial Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Raquibul Hannan
      • Dallas, Texas, Forenede Stater, 75237
        • Rekruttering
        • UT Southwestern Simmons Cancer Center - RedBird
        • Ledende efterforsker:
          • Raquibul Hannan
        • Kontakt:
      • Fort Worth, Texas, Forenede Stater, 76104
        • Rekruttering
        • UT Southwestern/Simmons Cancer Center-Fort Worth
        • Kontakt:
        • Ledende efterforsker:
          • Raquibul Hannan
      • Richardson, Texas, Forenede Stater, 75080
        • Rekruttering
        • UT Southwestern Clinical Center at Richardson/Plano
        • Kontakt:
        • Ledende efterforsker:
          • Raquibul Hannan
      • Temple, Texas, Forenede Stater, 76508
        • Rekruttering
        • Scott and White Memorial Hospital
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 254-724-5407
        • Ledende efterforsker:
          • Lucas Wong
    • Vermont
      • Berlin Corners, Vermont, Forenede Stater, 05602
        • Rekruttering
        • Central Vermont Medical Center/National Life Cancer Treatment
        • Ledende efterforsker:
          • Nataniel H. Lester-Coll
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 802-225-5400
      • Burlington, Vermont, Forenede Stater, 05401
        • Rekruttering
        • University of Vermont Medical Center
        • Ledende efterforsker:
          • Nataniel H. Lester-Coll
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 802-656-4101
          • E-mail: rpo@uvm.edu
      • Burlington, Vermont, Forenede Stater, 05405
        • Rekruttering
        • University of Vermont and State Agricultural College
        • Ledende efterforsker:
          • Nataniel H. Lester-Coll
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 802-656-8990
          • E-mail: rpo@uvm.edu
    • Virginia
      • Alexandria, Virginia, Forenede Stater, 22304
        • Rekruttering
        • Inova Alexandria Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Daniel W. Kim
      • Fairfax, Virginia, Forenede Stater, 22031
        • Rekruttering
        • Inova Schar Cancer Institute
        • Kontakt:
        • Ledende efterforsker:
          • Daniel W. Kim
      • Fairfax, Virginia, Forenede Stater, 22033
        • Rekruttering
        • Inova Fair Oaks Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Daniel W. Kim
      • Midlothian, Virginia, Forenede Stater, 23114
        • Rekruttering
        • Bon Secours Saint Francis Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Joseph D. Pennington
      • Richmond, Virginia, Forenede Stater, 23235
        • Rekruttering
        • VCU Massey Cancer Center at Stony Point
        • Kontakt:
        • Ledende efterforsker:
          • Alfredo I. Urdaneta
      • Richmond, Virginia, Forenede Stater, 23230
        • Rekruttering
        • Bon Secours Cancer Institute at Reynolds Crossing
        • Kontakt:
        • Ledende efterforsker:
          • Joseph D. Pennington
      • Richmond, Virginia, Forenede Stater, 23298
        • Rekruttering
        • VCU Massey Comprehensive Cancer Center
        • Ledende efterforsker:
          • Alfredo I. Urdaneta
        • Kontakt:
    • Washington
      • Seattle, Washington, Forenede Stater, 98101
        • Rekruttering
        • Virginia Mason Medical Center
        • Ledende efterforsker:
          • Huong T. Pham
        • Kontakt:
    • West Virginia
      • Charleston, West Virginia, Forenede Stater, 25304
        • Aktiv, ikke rekrutterende
        • Vandalia Health/CAMC Institute for Academic Medicine
      • Huntington, West Virginia, Forenede Stater, 25701
        • Rekruttering
        • Edwards Comprehensive Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Toni O. Pacioles
    • Wisconsin
      • Antigo, Wisconsin, Forenede Stater, 54409
        • Rekruttering
        • Aspirus Cancer Care-Antigo-Volm Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Andrew J. Huang
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Rekruttering
        • Duluth Clinic Ashland
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Ashland, Wisconsin, Forenede Stater, 54806
        • Rekruttering
        • Northwest Wisconsin Cancer Center
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Eau Claire, Wisconsin, Forenede Stater, 54701
      • Green Bay, Wisconsin, Forenede Stater, 54301
        • Rekruttering
        • Saint Vincent Hospital Cancer Center Green Bay
        • Ledende efterforsker:
          • Matthew L. Ryan
        • Kontakt:
      • Green Bay, Wisconsin, Forenede Stater, 54303
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Saint Mary's
        • Ledende efterforsker:
          • Matthew L. Ryan
        • Kontakt:
      • Hayward, Wisconsin, Forenede Stater, 54843
        • Rekruttering
        • Essentia Health-Hayward Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • La Crosse, Wisconsin, Forenede Stater, 54601
        • Rekruttering
        • Gundersen Lutheran Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Collin D. Driscoll
      • Ladysmith, Wisconsin, Forenede Stater, 54848
        • Aktiv, ikke rekrutterende
        • Marshfield Medical Center - Ladysmith
      • Madison, Wisconsin, Forenede Stater, 53792
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - University Hospital
        • Kontakt:
        • Ledende efterforsker:
          • Amy K. Taylor
      • Madison, Wisconsin, Forenede Stater, 53718
        • Rekruttering
        • University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
        • Kontakt:
        • Ledende efterforsker:
          • Amy K. Taylor
      • Marshfield, Wisconsin, Forenede Stater, 54449
      • Menomonee Falls, Wisconsin, Forenede Stater, 53051
        • Rekruttering
        • Froedtert Menomonee Falls Hospital
        • Ledende efterforsker:
          • William A. Hall
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 262-257-5100
      • Milwaukee, Wisconsin, Forenede Stater, 53226
        • Rekruttering
        • Medical College of Wisconsin
        • Ledende efterforsker:
          • William A. Hall
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 414-805-3666
      • Minocqua, Wisconsin, Forenede Stater, 54548
      • Mukwonago, Wisconsin, Forenede Stater, 53149
        • Rekruttering
        • ProHealth D N Greenwald Center
        • Kontakt:
        • Ledende efterforsker:
          • Timothy R. Wassenaar
      • Neillsville, Wisconsin, Forenede Stater, 54456
        • Aktiv, ikke rekrutterende
        • Marshfield Medical Center - Neillsville
      • New Richmond, Wisconsin, Forenede Stater, 54017
        • Rekruttering
        • Cancer Center of Western Wisconsin
        • Kontakt:
        • Ledende efterforsker:
          • Charles Shideman
      • Oak Creek, Wisconsin, Forenede Stater, 53154
        • Rekruttering
        • Drexel Town Square Health Center
        • Ledende efterforsker:
          • William A. Hall
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 414-805-0505
      • Oconomowoc, Wisconsin, Forenede Stater, 53066
        • Rekruttering
        • ProHealth Oconomowoc Memorial Hospital
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 262-928-7878
      • Rhinelander, Wisconsin, Forenede Stater, 54501
        • Rekruttering
        • Aspirus Cancer Care-Rhinelander-James Beck Cancer Center
        • Ledende efterforsker:
          • Andrew J. Huang
        • Kontakt:
      • Rice Lake, Wisconsin, Forenede Stater, 54868
      • Sheboygan, Wisconsin, Forenede Stater, 53081
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Sheboygan
        • Ledende efterforsker:
          • Matthew L. Ryan
        • Kontakt:
      • Spooner, Wisconsin, Forenede Stater, 54801
        • Rekruttering
        • Essentia Health-Spooner Clinic
        • Kontakt:
        • Ledende efterforsker:
          • Bret E. Friday
      • Stevens Point, Wisconsin, Forenede Stater, 54482
      • Stevens Point, Wisconsin, Forenede Stater, 54481
        • Rekruttering
        • Aspirus Cancer Care - Stevens Point
        • Ledende efterforsker:
          • Andrew J. Huang
        • Kontakt:
      • Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
        • Rekruttering
        • Saint Vincent Hospital Cancer Center at Sturgeon Bay
        • Ledende efterforsker:
          • Matthew L. Ryan
        • Kontakt:
      • Superior, Wisconsin, Forenede Stater, 54880
        • Rekruttering
        • Essentia Health Saint Mary's Hospital - Superior
        • Ledende efterforsker:
          • Bret E. Friday
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 701-364-6272
      • Waukesha, Wisconsin, Forenede Stater, 53188
        • Rekruttering
        • UW Cancer Center at ProHealth Care
        • Ledende efterforsker:
          • Timothy R. Wassenaar
        • Kontakt:
      • Wausau, Wisconsin, Forenede Stater, 54401
        • Rekruttering
        • Aspirus Cancer Care-Wausau
        • Ledende efterforsker:
          • Andrew J. Huang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 877-405-6866
      • West Bend, Wisconsin, Forenede Stater, 53095
        • Rekruttering
        • Froedtert West Bend Hospital/Kraemer Cancer Center
        • Ledende efterforsker:
          • William A. Hall
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 414-805-0505
      • Weston, Wisconsin, Forenede Stater, 54476
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Rekruttering
        • Aspirus Cancer Care - Wisconsin Rapids
        • Ledende efterforsker:
          • Andrew J. Huang
        • Kontakt:
          • Site Public Contact
          • Telefonnummer: 715-422-7718
      • Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
        • Aktiv, ikke rekrutterende
        • Marshfield Clinic - Wisconsin Rapids Center
    • Co Dublin
      • Dublin, Co Dublin, Irland, 18
        • Suspenderet
        • Beacon Hospital
      • Dublin, Co Dublin, Irland, 6
        • Suspenderet
        • Saint Lukes Hospital
    • Co Galway
      • Galway, Co Galway, Irland
        • Suspenderet
        • University College Hospital Galway

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Køn, der er berettiget til at studere

Alle

Beskrivelse

Inclusion Criteria:

  • Pathologically (histologically or cytologically) proven diagnosis of renal cell carcinoma prior to registration

  • Node-positive unresectable (TxN1Mx) or metastatic (TxNxM1) based on the following diagnostic workup:

    • History/physical examination within 45 days prior to registration
    • CT/magnetic resonance imaging (MRI) of the chest/abdomen/pelvis within 45 days prior to registration
  • Patients must have IMDC intermediate (1-2 factors) or poor risk disease (>= 3 factors)

  • Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial

  • Patients with measurable disease (node positive or metastatic) as defined by RECIST version 1.1 excluding the primary renal tumor

  • Patient not recommended for or refused immediate cytoreductive nephrectomy

  • Candidate for standard of care therapy with either immuno-oncology (IO)-IO or IO-VEGF combination regimen

  • Primary renal tumor measuring 20 cm or less in anterior to posterior dimension only on axial imaging

  • Age >= 18

  • Karnofsky performance status >= 60 within 45 days prior to registration

  • Hemoglobin >= 8 g/dL (transfusions are allowed) (within 45 days prior to registration)

  • Platelet count >= 50,000/mm^3 (within 45 days prior to registration)

  • Absolute neutrophil count (ANC) >= 1500/mm^3 (within 45 days prior to registration)

  • Calculated (Calc.) creatinine clearance >= 30 mL/min (within 45 days prior to registration)

    • Creatinine clearance (CrCl) >= 30 mL/min estimated by Cockcroft-Gault Equation
    • For African American patients specifically whose renal function is not considered adequate by the formula above, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) should be used for calculating the related estimated glomerular filtration rate (GFR) with a correction factor for African American race creatinine clearance for trial eligibility, where GFR >= 30 mL/min/1.73m^2 will be considered adequate
  • Total bilirubin =< 1.5 x upper limit of normal (ULN) (except subjects with Gilbert Syndrome, who can have total bilirubin < 3.0 mg/dL) (within 45 days prior to registration)

  • Aspartate aminotransferase and alanine aminotransferase (AST and ALT) =< 3 x upper limit of normal (ULN) or < 5 x ULN if hepatic metastases present (within 45 days prior to registration)

  • Patients with known human immunodeficiency virus (HIV) on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial. Testing is not required for entry into protocol

  • For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated

  • Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. Patients with HCV infection who are currently on treatment are eligible if they have an undetectable HCV viral load

  • The patient must agree to use a highly effective contraception, including men with vasectomies if they are having sex with a woman of childbearing potential or with a woman who is pregnant, while on study drug and for 6 months following the last dose of study drug. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal

  • The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

Exclusion Criteria:

  • Patients with planned treatment of all metastatic disease with definitive therapy including either surgery, ablative (non-palliative) doses of radiation, or intervention of some type (definitive interventional radiology techniques) to ALL metastatic sites rendering the patient without extra-renal measurable disease. Patients NOT planned for definitive treatment of all metastatic sites are eligible. Lesions radiated palliatively are not eligible for response assessment

  • Patients with untreated or unstable brain metastases or cranial epidural disease

    • Note: Patients who have been adequately treated with radiotherapy, radiosurgery, or surgery and stable for at least 4 weeks prior to registration as documented by MRI or CT imaging or deemed stable by clinical investigator are eligible. Treated brain metastases are defined as having no ongoing requirement for steroids and no evidence of progression or hemorrhage after treatment for at least 4 weeks prior to registration as documented by MRI or CT imaging or deemed stable by clinical investigator
  • Prior radiotherapy to the kidney that would result in overlap of radiation therapy fields treatment of the primary tumor

  • Any systemic therapy for metastatic renal cell carcinoma (RCC) that was initiated > 90 days before registration, note that prior chemotherapy for a different cancer is allowed (completed > 3 years prior to registration)

  • Severe, active comorbidity defined as follows:

    • Active autoimmune disease requiring ongoing therapy including systemic treatment with corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications daily. Inhaled steroids and adrenal replacement steroid doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease
    • History of severe allergic, anaphylactic or other hypersensitivity reactions to chimeric or humanized antibodies
    • Active tuberculosis (purified protein derivative [PPD] response without active tuberculosis [TB] is allowed)
    • Uncontrolled hypertension (systolic blood pressure [BP] >= 190 mmHg or diastolic BP > 110 mmHg)
    • Major surgery requiring hospital admission =< 28 days prior to registration
    • Any serious (requiring hospital stay or long term rehab) non-healing wound, ulcer, or bone fracture within 45 days prior to registration
    • Any arterial thrombotic (ST elevation myocardial infarction [STEMI], non-ST elevation myocardial infarction [NSTEMI], cerebrovascular accident [CVA], etc) events within 180 days prior to registration
    • Active New York (NY) Heart Association class 3-4 heart failure symptoms
    • Moderate or severe hepatic impairment (Child-Pugh B or C)
    • Any history of untreated pulmonary embolism or deep venous thrombosis (DVT) within 180 days prior to registration. (Any asymptomatic or treated pulmonary embolism or asymptomatic treated deep venous thrombosis > 30 days prior to registration is allowed)
    • Unstable cardiac arrhythmia within 180 days prior to registration
    • History of abdominal fistula, gastrointestinal perforation, intra-abdominal abscess, bowel obstruction, or gastric outlet obstruction within 180 days prior to registration
    • History of or active inflammatory bowel disease
    • Malabsorption syndrome within 45 days prior to registration
  • Pregnancy and individuals unwilling to discontinue nursing. For women of child bearing potential must have a negative pregnancy test =< 45 days prior to registration

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

  • Primært formål: Behandling
  • Tildeling: Randomiseret
  • Interventionel model: Parallel tildeling
  • Maskning: Ingen (Åben etiket)

Våben og indgreb

Deltagergruppe / Arm
Intervention / Behandling
Aktiv komparator: Arm I (standard of care immunotherapy)

Patients receive one of the following immunotherapy regimens per physician discretion: nivolumab IV over 30 minutes and ipilimumab IV over 30 minutes every 3 weeks for 4 doses followed by nivolumab IV over 30 minutes every 2 or 4 weeks; pembrolizumab IV over 30 minutes every 3 or 6 weeks and axitinib PO BID; avelumab IV over 60 minutes every 2 weeks and axitinib PO BID; nivolumab IV over 30 minutes every 2 or 4 weeks and cabozantinib PO QD; OR pembrolizumab IV over 30 minutes every 3 or 6 weeks and lenvatinib PO QD. Treatment with immunotherapy continues in the absence of disease progression or unacceptable toxicity. Patients also undergo CT scan or MRI throughout the trial. Patients may also undergo a bone scan as clinically indicated and blood sample collection throughout the trial.

Given IV

Andre navne:
  • Anti-cytotoksisk T-lymfocyt-associeret antigen-4 monoklonalt antistof
  • BMS-734016
  • Ipilimumab Biosimilar CS1002
  • MDX-010
  • MDX-CTLA4
  • Yervoy
  • MDX010
  • BMS734016
  • BMS 734016
  • MDX 010

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR

Undergo collection of blood

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion

Given IV

Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538

Given IV

Andre navne:
  • Keytruda
  • MK-3475
  • Lambrolizumab
  • SCH 900475
  • MK3475
  • SCH-900475
  • BCD-201
  • Pembrolizumab Biosimilar BCD-201
  • Pembrolizumab Biosimilar QL2107
  • QL2107
  • GME 751
  • GME751
  • Pembrolizumab Biosimilar GME751
  • MK 3475
  • SCH900475
  • Pembrolizumab Biosimilar RPH-075
  • RPH 075
  • RPH-075
  • RPH075
  • Pembrolizumab Biosimilar SB27
  • SB 27
  • SB-27
  • SB27

Undergo bone scan

Andre navne:
  • Knoglescintigrafi

Given PO

Given IV

Andre navne:
  • Bavencio
  • MSB-0010718C
  • MSB0010718C
  • MSB 0010718C

Given PO

Andre navne:
  • AG-013736
  • AG013736
  • Inlyta
  • AG 013736

Given PO

Andre navne:
  • E7080
  • ER-203492-00
  • Multi-Kinase Inhibitor E7080
  • E 7080
  • E-7080
Eksperimentel: Arm II (SABR, standard of care immunotherapy)

Patients undergo SABR on 3 different days over 1-3 weeks and receive immunotherapy as in Arm I. Patients also undergo CT scan or MRI throughout the trial. Patients may also undergo a bone scan as clinically indicated and blood sample collection throughout the trial.

Given IV

Andre navne:
  • Anti-cytotoksisk T-lymfocyt-associeret antigen-4 monoklonalt antistof
  • BMS-734016
  • Ipilimumab Biosimilar CS1002
  • MDX-010
  • MDX-CTLA4
  • Yervoy
  • MDX010
  • BMS734016
  • BMS 734016
  • MDX 010

Undergo CT

Andre navne:
  • CT
  • KAT
  • CAT-scanning
  • Beregnet aksial tomografi
  • Computerstyret aksial tomografi
  • Computerstyret tomografi
  • CT-scanning
  • tomografi
  • Computerstyret aksial tomografi (procedure)
  • Computerstyret tomografi (CT) scanning
  • Diagnostisk CAT -scanning
  • Diagnostic CAT Scan Service Type

Undergo MRI

Andre navne:
  • MR
  • Magnetisk resonans
  • Magnetisk resonansbilledscanning
  • Medicinsk billeddannelse, magnetisk resonans / kernemagnetisk resonans
  • HR
  • MR billeddannelse
  • MR-scanning
  • NMR billeddannelse
  • NMRI
  • Kernemagnetisk resonansbilleddannelse
  • Magnetisk resonansbilleddannelse (MRI)
  • sMRI
  • Magnetisk resonansbilleddannelse (procedure)
  • MRI'er
  • Strukturel MR

Undergo collection of blood

Andre navne:
  • Biologisk prøvesamling
  • Bioprøve indsamlet
  • Prøvesamling
  • Prøvekollektion

Given IV

Andre navne:
  • BMS-936558
  • MDX-1106
  • NIVO
  • ONO-4538
  • Opdivo
  • CMAB819
  • Nivolumab Biosimilar CMAB819
  • MDX 1106
  • MDX1106
  • BMS 936558
  • ABP 206
  • Nivolumab Biosimilar ABP 206
  • BCD-263
  • Nivolumab Biosimilar BCD-263
  • BMS936558
  • ONO 4538
  • ONO4538

Given IV

Andre navne:
  • Keytruda
  • MK-3475
  • Lambrolizumab
  • SCH 900475
  • MK3475
  • SCH-900475
  • BCD-201
  • Pembrolizumab Biosimilar BCD-201
  • Pembrolizumab Biosimilar QL2107
  • QL2107
  • GME 751
  • GME751
  • Pembrolizumab Biosimilar GME751
  • MK 3475
  • SCH900475
  • Pembrolizumab Biosimilar RPH-075
  • RPH 075
  • RPH-075
  • RPH075
  • Pembrolizumab Biosimilar SB27
  • SB 27
  • SB-27
  • SB27

Undergo bone scan

Andre navne:
  • Knoglescintigrafi

Given PO

Given IV

Andre navne:
  • Bavencio
  • MSB-0010718C
  • MSB0010718C
  • MSB 0010718C

Given PO

Andre navne:
  • AG-013736
  • AG013736
  • Inlyta
  • AG 013736

Given PO

Andre navne:
  • E7080
  • ER-203492-00
  • Multi-Kinase Inhibitor E7080
  • E 7080
  • E-7080

42 Gy in 3 fractions

Andre navne:
  • SABRE
  • SABR/SBRT

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Nephrectomy and radiographic progression-free survival (nrPFS)
Tidsramme: From randomization to last follow-up, up to 8 years

Nephrectomy and radiographic progression-free survival time is defined as time from randomization to the date of first radiographic progression, nephrectomy, death, or last negative evaluation (censored). nrPFS rates are estimated using the Kaplan-Meier method. Progression is determined by the Response Evaluation Criteria in Solid Tumors version 1.1 criteria modified for immunotherapy trials (iRECIST).

From randomization to last follow-up, up to 8 years

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Procentdel af deltagere, der gennemgår cytoreduktiv nefrektomi
Tidsramme: Fra randomisering til sidste opfølgning, op til 8 år
Fra randomisering til sidste opfølgning, op til 8 år
Percentage of participants with complete or partial response
Tidsramme: From randomization to disease progression

Best overall response is determined by the iRECIST version 1.1.

From randomization to disease progression
Percentage of participants with complete or partial response in the primary renal mass
Tidsramme: From randomization to disease progression

Best overall response is determined by the iRECIST version 1.1.

From randomization to disease progression
Radiographic progression-free survival (rPFS)
Tidsramme: From randomization to last follow-up, up to 8 years

Radiographic progression-free survival time is defined as time from randomization to the date of first radiographic progression, death, or last negative evaluation (censored). rPFS rates are estimated using the Kaplan-Meier method. Radiographic progression is determined by the iRECIST version 1.1.

From randomization to last follow-up, up to 8 years
Nephrectomy and radiographic progression-free survival excluding nephrectomies that were performed for non-protocol specified reasons (nrPFS2)
Tidsramme: From randomization to last follow-up, up to 8 years

Nephrectomy and radiographic progression-free survival time (excluding nephrectomies that were performed for non-protocol specified reasons) is defined as time from randomization to the date of first radiographic progression, nephrectomy performed for protocol-stated reasons, death, or last negative evaluation (censored). nrPFS2 rates are estimated using the Kaplan-Meier method. Progression is determined by the iRECIST version 1.1.

From randomization to last follow-up, up to 8 years
Overall survival
Tidsramme: From randomization to last follow-up, up to 8 years

Overall survival time is defined as time from randomization to the date of death or last known follow-up (censored). Overall survival rates are estimated by the Kaplan-Meier method.

From randomization to last follow-up, up to 8 years
Second-line therapy-free survival
Tidsramme: From randomization to last follow-up, up to 8 years

Second-line therapy-free survival time is defined as time from randomization to the date of the initiation of second-line therapy, death, or last known follow-up (censored). Second-line therapy-free survival rates are estimated using the Kaplan-Meier method.

From randomization to last follow-up, up to 8 years
Treatment-free survival
Tidsramme: From randomization to last follow-up, up to 8 years

Treatment-free survival time is defined as time from the discontinuation of protocol therapy to the date of death or last follow-up (censored). Treatment-free survival rates are estimated using the Kaplan-Meier method.

From randomization to last follow-up, up to 8 years
Percentage of participants with adverse events
Tidsramme: From randomization to last follow-up, up to 8 years

Common Terminology Criteria for Adverse Events 5.0 grades adverse event severity from 1=mild to 5=death.

From randomization to last follow-up, up to 8 years

Andre resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
nrPFS and overall survival
Tidsramme: From randomization to last follow-up, up to 8 years

Exploratory analyses will compare nrPFS and overall survival in four pre-defined subgroups: clear cell versus (vs.) non-clear cell histology, intermediate vs. poor International Metastatic RCC database consortium risk group, treatment with immuno-oncology (IO)-IO vs. IO-vascular endothelial growth factor, and sarcomatoid vs. non sarcomatoid variant. Forest plots will be constructed showing estimated hazard ratios from Cox models and 90% confidence intervals generated within each subgroup. Treatment-by-subgroup interaction terms will be incorporated into the Cox modelling to assess whether the effect of stereotactic ablative radiotherapy (SABR) varies significantly by subgroup; however, these analyses will be considered hypothesis-generating only.

From randomization to last follow-up, up to 8 years
Prognostic and predictive biomarkers
Tidsramme: From randomization to last follow-up, up to 8 years

Will be accomplished by including the biomarkers in Cox time-to-event regression models for the evaluation of prognostic factors. Treatment-by-biomarker interaction terms will be incorporated into the modelling process to assess for potential predictive markers.

From randomization to last follow-up, up to 8 years
Abscopal effect of SABR with systemic therapy
Tidsramme: From randomization to disease progression

These analyses will include only patients in the control arm who have not received any palliative radiation therapy and those in the experimental arm who have received protocol defined stereotactic body radiation therapy only without additional radiation therapy. Response rates among lesions outside the renal mass will be determined based in iRECIST criteria and compared using a chi-square test.

From randomization to disease progression
Impact of treatment on the level of inferior vena cava (IVC) thrombus
Tidsramme: From randomization to last follow-up, up to 8 years

Will be assessed by comparing the rates of IVC thromboembolism using Fisher's exact test. Cumulative incidence curves with death as a competing risk will also be generated and compared using the Fine-Gray test.

From randomization to last follow-up, up to 8 years
Accuracy of accruing center radiologist defined progression as compared with central radiology defined progression
Tidsramme: From randomization to last follow-up, up to 8 years

This will take place at the conclusion of the trial by our diagnostic radiologists. Will determine the number and proportion of center radiologist defined progressions (confirmed per iRECIST) that are validated/not validated upon central review. Will also examine all center radiologist defined pseudo progressions (i.e., not confirmed per iRECIST) and determine the number that are also declared pseudo progressions upon central review.

From randomization to last follow-up, up to 8 years

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Samarbejdspartnere

Efterforskere

  • Ledende efterforsker: William A Hall, NRG Oncology

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

1. februar 2023

Primær færdiggørelse (Anslået)

15. juni 2028

Studieafslutning (Anslået)

15. juni 2033

Datoer for studieregistrering

Først indsendt

7. april 2022

Først indsendt, der opfyldte QC-kriterier

7. april 2022

Først opslået (Faktiske)

14. april 2022

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

23. oktober 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

21. oktober 2026

Sidst verificeret

1. oktober 2026

Mere information

Begreber relateret til denne undersøgelse

Andre undersøgelses-id-numre

  • NRG-GU012
  • U10CA180868 (U.S. NIH-bevilling/kontrakt)
  • NRG-GU012 (Anden identifikator: CTEP)
  • NCI-2022-02189 (Registry Identifier: CTRP (Clinical Trial Reporting Program))
  • NRG-GU012 (Anden identifikator: NRG Oncology)

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Ja

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

produkt fremstillet i og eksporteret fra U.S.A.

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

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