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Ramucirumab Plus Pembrolizumab vs standardkemoterapi til behandling af trin IV eller tilbagevendende ikke-småcellet lungekræft efter immunterapi, Pragmatica-lungeundersøgelse

14. april 2026 opdateret af: SWOG Cancer Research Network

Pragmatica-Lung: A Prospective Randomized Study of Ramucirumab (LY3009806; NSC 749128) Plus Pembrolizumab (MK-3475; NSC 776864) Versus Standard of Care for deltagere, der tidligere er behandlet med immunterapi for trin IV-cancercelle-stadie eller tilbagevendende celle

Dette fase III-forsøg sammenligner effekten af kombinationen af ramucirumab og pembrolizumab versus standardbehandling kemoterapi til behandling af ikke-småcellet lungekræft, som er stadium IV, eller som er vendt tilbage efter en periode med bedring (tilbagevendende). Ramucirumab er et monoklonalt antistof, der kan forhindre væksten af nye blodkar, som tumorer har brug for for at vokse. Immunterapi med monoklonale antistoffer, såsom pembrolizumab, kan hjælpe kroppens immunsystem med at angribe kræften og kan forstyrre tumorcellernes evne til at vokse og sprede sig. Kemoterapimedicin virker på forskellige måder for at stoppe væksten af tumorceller, enten ved at dræbe cellerne, ved at stoppe dem i at dele sig eller ved at stoppe dem i at sprede sig. Dette forsøg kan hjælpe læger med at finde ud af, om det at give ramucirumab sammen med pembrolizumab er mere effektivt til behandling af patienter med stadium IV eller tilbagevendende ikke-småcellet lungekræft end standard kemoterapi.

Studieoversigt

Status

Aktiv, ikke rekrutterende

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

PRIMÆR MÅL:

I. At sammenligne overordnet overlevelse (OS) hos deltagere tidligere behandlet med platinbaseret kemoterapi og immunterapi for stadium IV eller tilbagevendende ikke-småcellet lungekræft (NSCLC) randomiseret til pembrolizumab og ramucirumab versus standardbehandling.

SEKUNDÆR MÅL:

I. At opsummere rapporter om alvorlige og uventede højgradige (>= grad 3) behandlingsrelaterede uønskede hændelser bestemt af den behandlende læge inden for hver behandlingsarm.

OVERSIGT: Patienterne randomiseres til 1 af 2 arme.

ARM A: Patienter modtager kemoterapi pr. standardbehandling i undersøgelsen.

ARM B: Patienterne får ramucirumab intravenøst (IV) og pembrolizumab IV i undersøgelsen.

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

838

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Forenede Stater
- Alabama
  - Birmingham, Alabama, Forenede Stater, 35233
    - University of Alabama at Birmingham Cancer Center
  - Mobile, Alabama, Forenede Stater, 36688
    - University of South Alabama Mitchell Cancer Institute
- Arizona
  - Tucson, Arizona, Forenede Stater, 85719
    - Banner University Medical Center - Tucson
  - Tucson, Arizona, Forenede Stater, 85719
    - University of Arizona Cancer Center-North Campus
- Arkansas
  - Fayetteville, Arkansas, Forenede Stater, 72703
    - Highlands Oncology Group - Fayetteville
  - Fort Smith, Arkansas, Forenede Stater, 72903
    - Mercy Hospital Fort Smith
  - Little Rock, Arkansas, Forenede Stater, 72205
    - University of Arkansas for Medical Sciences
  - Little Rock, Arkansas, Forenede Stater, 72205
    - John L McClellan Memorial Veterans Hospital
  - Rogers, Arkansas, Forenede Stater, 72758
    - Highlands Oncology Group - Rogers
  - Springdale, Arkansas, Forenede Stater, 72762
    - Highlands Oncology Group
- California
  - Anaheim, California, Forenede Stater, 92806
    - Kaiser Permanente-Anaheim
  - Arroyo Grande, California, Forenede Stater, 93420
    - PCR Oncology
  - Auburn, California, Forenede Stater, 95602
    - Sutter Auburn Faith Hospital
  - Baldwin Park, California, Forenede Stater, 91706
    - Kaiser Permanente-Baldwin Park
  - Bellflower, California, Forenede Stater, 90706
    - Kaiser Permanente-Bellflower
  - Berkeley, California, Forenede Stater, 94704
    - Alta Bates Summit Medical Center-Herrick Campus
  - Beverly Hills, California, Forenede Stater, 90211
    - Tower Cancer Research Foundation
  - Cameron Park, California, Forenede Stater, 95682
    - Marshall Cancer Center
  - Duarte, California, Forenede Stater, 91010
    - City of Hope Comprehensive Cancer Center
  - Dublin, California, Forenede Stater, 94568
    - Kaiser Permanente Dublin
  - Fontana, California, Forenede Stater, 92335
    - Kaiser Permanente-Fontana
  - Fremont, California, Forenede Stater, 94538
    - Kaiser Permanente-Fremont
  - Fremont, California, Forenede Stater, 94538
    - Palo Alto Medical Foundation-Fremont
  - Harbor City, California, Forenede Stater, 90710
    - Kaiser Permanente - Harbor City
  - Huntington Beach, California, Forenede Stater, 92648
    - City of Hope at Huntington Beach
  - Irvine, California, Forenede Stater, 92618
    - Kaiser Permanente-Irvine
  - Irvine, California, Forenede Stater, 92618
    - City of Hope at Irvine Lennar
  - Lancaster, California, Forenede Stater, 93534
    - City of Hope Antelope Valley
  - Loma Linda, California, Forenede Stater, 92354
    - Loma Linda University Medical Center
  - Long Beach, California, Forenede Stater, 90813
    - City of Hope at Long Beach Elm
  - Los Angeles, California, Forenede Stater, 90027
    - Kaiser Permanente Los Angeles Medical Center
  - Los Angeles, California, Forenede Stater, 90048
    - Cedars Sinai Medical Center
  - Los Angeles, California, Forenede Stater, 90034
    - Kaiser Permanente West Los Angeles
  - Marysville, California, Forenede Stater, 95901
    - Fremont - Rideout Cancer Center
  - Modesto, California, Forenede Stater, 95355
    - Memorial Medical Center
  - Modesto, California, Forenede Stater, 95356
    - Kaiser Permanente-Modesto
  - Newport Beach, California, Forenede Stater, 92660
    - City of Hope Newport Beach
  - Oakland, California, Forenede Stater, 94611
    - Kaiser Permanente-Oakland
  - Ontario, California, Forenede Stater, 91761
    - Kaiser Permanente-Ontario
  - Palo Alto, California, Forenede Stater, 94301
    - Palo Alto Medical Foundation Health Care
  - Panorama City, California, Forenede Stater, 91402
    - Kaiser Permanente - Panorama City
  - Riverside, California, Forenede Stater, 92505
    - Kaiser Permanente-Riverside
  - Roseville, California, Forenede Stater, 95661
    - Kaiser Permanente-Roseville
  - Roseville, California, Forenede Stater, 95661
    - Sutter Roseville Medical Center
  - Sacramento, California, Forenede Stater, 95816
    - Sutter Medical Center Sacramento
  - Sacramento, California, Forenede Stater, 95817
    - University of California Davis Comprehensive Cancer Center
  - Sacramento, California, Forenede Stater, 95814
    - Kaiser Permanente Downtown Commons
  - Sacramento, California, Forenede Stater, 95823
    - Kaiser Permanente-South Sacramento
  - San Diego, California, Forenede Stater, 92120
    - Kaiser Permanente-San Diego Zion
  - San Francisco, California, Forenede Stater, 94115
    - Kaiser Permanente-San Francisco
  - San Francisco, California, Forenede Stater, 94115
    - California Pacific Medical Center-Pacific Campus
  - San Jose, California, Forenede Stater, 95119
    - Kaiser Permanente-Santa Teresa-San Jose
  - San Leandro, California, Forenede Stater, 94577
    - Kaiser Permanente San Leandro
  - San Marcos, California, Forenede Stater, 92078
    - Kaiser Permanente-San Marcos
  - San Rafael, California, Forenede Stater, 94903
    - Kaiser San Rafael-Gallinas
  - Santa Clara, California, Forenede Stater, 95051
    - Kaiser Permanente Medical Center - Santa Clara
  - Santa Cruz, California, Forenede Stater, 95065
    - Palo Alto Medical Foundation-Santa Cruz
  - Santa Rosa, California, Forenede Stater, 95403
    - Kaiser Permanente-Santa Rosa
  - South Pasadena, California, Forenede Stater, 91030
    - City of Hope South Pasadena
  - South San Francisco, California, Forenede Stater, 94080
    - Kaiser Permanente-South San Francisco
  - Sunnyvale, California, Forenede Stater, 94086
    - Palo Alto Medical Foundation-Sunnyvale
  - Torrance, California, Forenede Stater, 90505
    - Torrance Memorial Physician Network - Cancer Care
  - Truckee, California, Forenede Stater, 96161
    - Gene Upshaw Memorial Tahoe Forest Cancer Center
  - Upland, California, Forenede Stater, 91786
    - City of Hope Upland
  - Vallejo, California, Forenede Stater, 94589
    - Kaiser Permanente-Vallejo
  - Vallejo, California, Forenede Stater, 94589
    - Sutter Solano Medical Center/Cancer Center
  - Walnut Creek, California, Forenede Stater, 94596
    - Kaiser Permanente-Walnut Creek
  - Whittier, California, Forenede Stater, 90602
    - Presbyterian Intercommunity Hospital
  - Woodland Hills, California, Forenede Stater, 91367
    - Kaiser Permanente-Woodland Hills
- Colorado
  - Aurora, Colorado, Forenede Stater, 80045
    - Rocky Mountain Regional VA Medical Center
  - Aurora, Colorado, Forenede Stater, 80045
    - UCHealth University of Colorado Hospital
  - Colorado Springs, Colorado, Forenede Stater, 80909
    - UCHealth Memorial Hospital Central
  - Colorado Springs, Colorado, Forenede Stater, 80920
    - Memorial Hospital North
  - Denver, Colorado, Forenede Stater, 80205
    - Kaiser Permanente-Franklin
  - Fort Collins, Colorado, Forenede Stater, 80524
    - Poudre Valley Hospital
  - Fort Collins, Colorado, Forenede Stater, 80528
    - Cancer Care and Hematology-Fort Collins
  - Greeley, Colorado, Forenede Stater, 80631
    - UCHealth Greeley Hospital
  - Lafayette, Colorado, Forenede Stater, 80026
    - Kaiser Permanente-Rock Creek
  - Lone Tree, Colorado, Forenede Stater, 80124
    - Kaiser Permanente-Lone Tree
  - Lone Tree, Colorado, Forenede Stater, 80124
    - UCHealth Lone Tree Health Center
  - Loveland, Colorado, Forenede Stater, 80538
    - Medical Center of the Rockies
- Connecticut
  - Derby, Connecticut, Forenede Stater, 06418
    - Smilow Cancer Hospital-Derby Care Center
  - Fairfield, Connecticut, Forenede Stater, 06824
    - Smilow Cancer Hospital Care Center-Fairfield
  - Glastonbury, Connecticut, Forenede Stater, 06033
    - Smilow Cancer Hospital Care Center at Glastonbury
  - Greenwich, Connecticut, Forenede Stater, 06830
    - Smilow Cancer Hospital Care Center at Greenwich
  - Guilford, Connecticut, Forenede Stater, 06437
    - Smilow Cancer Hospital Care Center - Guilford
  - Hartford, Connecticut, Forenede Stater, 06105
    - Smilow Cancer Hospital Care Center at Saint Francis
  - Hartford, Connecticut, Forenede Stater, 06102
    - Hartford Hospital
  - Meriden, Connecticut, Forenede Stater, 06451
    - Midstate Medical Center
  - New Britain, Connecticut, Forenede Stater, 06050
    - The Hospital of Central Connecticut
  - New Haven, Connecticut, Forenede Stater, 06520
    - Yale University
  - North Haven, Connecticut, Forenede Stater, 06473
    - Yale-New Haven Hospital North Haven Medical Center
  - Orange, Connecticut, Forenede Stater, 06477
    - Smilow Cancer Hospital-Orange Care Center
  - Stamford, Connecticut, Forenede Stater, 06904
    - Stamford Hospital/Bennett Cancer Center
  - Stamford, Connecticut, Forenede Stater, 06902
    - Smilow Cancer Hospital Care Center at Long Ridge
  - Torrington, Connecticut, Forenede Stater, 06790
    - Smilow Cancer Hospital-Torrington Care Center
  - Trumbull, Connecticut, Forenede Stater, 06611
    - Smilow Cancer Hospital Care Center-Trumbull
  - Waterbury, Connecticut, Forenede Stater, 06708
    - Smilow Cancer Hospital-Waterbury Care Center
  - Waterford, Connecticut, Forenede Stater, 06385
    - Smilow Cancer Hospital Care Center - Waterford
  - West Haven, Connecticut, Forenede Stater, 06516
    - Veterans Affairs Connecticut Healthcare System-West Haven Campus
- Delaware
  - Frankford, Delaware, Forenede Stater, 19945
    - Beebe South Coastal Health Campus
  - Newark, Delaware, Forenede Stater, 19713
    - Helen F Graham Cancer Center
  - Newark, Delaware, Forenede Stater, 19713
    - Medical Oncology Hematology Consultants PA
  - Rehoboth Beach, Delaware, Forenede Stater, 19971
    - Beebe Health Campus
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20010
    - MedStar Washington Hospital Center
  - Washington D.C., District of Columbia, Forenede Stater, 20002
    - Kaiser Permanente-Capitol Hill Medical Center
  - Washington D.C., District of Columbia, Forenede Stater, 20007
    - MedStar Georgetown University Hospital
- Florida
  - Aventura, Florida, Forenede Stater, 33180
    - UM Sylvester Comprehensive Cancer Center at Aventura
  - Coral Gables, Florida, Forenede Stater, 33146
    - UM Sylvester Comprehensive Cancer Center at Coral Gables
  - Deerfield Beach, Florida, Forenede Stater, 33442
    - UM Sylvester Comprehensive Cancer Center at Deerfield Beach
  - Gainesville, Florida, Forenede Stater, 32610
    - Malcom Randall Veterans Administration Medical Center
  - Lakeland, Florida, Forenede Stater, 33805
    - The Watson Clinic
  - Miami, Florida, Forenede Stater, 33136
    - University of Miami Miller School of Medicine-Sylvester Cancer Center
  - Miami Beach, Florida, Forenede Stater, 33140
    - Mount Sinai Medical Center
  - Plantation, Florida, Forenede Stater, 33324
    - UM Sylvester Comprehensive Cancer Center at Plantation
  - Tampa, Florida, Forenede Stater, 33612
    - Moffitt Cancer Center
  - Tampa, Florida, Forenede Stater, 33607
    - Moffitt Cancer Center-International Plaza
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30342
    - Northside Hospital
  - Duluth, Georgia, Forenede Stater, 30096
    - Northside Hospital - Duluth
  - Fort Gordon, Georgia, Forenede Stater, 30905-5650
    - Eisenhower Army Medical Center
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Medical Center-Gainesville
  - Lawrenceville, Georgia, Forenede Stater, 30046
    - Northside Hospital - Gwinnett
  - Savannah, Georgia, Forenede Stater, 31405
    - Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
  - Savannah, Georgia, Forenede Stater, 31404
    - Memorial Health University Medical Center
  - Tifton, Georgia, Forenede Stater, 31794
    - Tift Regional Medical Center
  - Valdosta, Georgia, Forenede Stater, 31602
    - South Georgia Medical Center/Pearlman Cancer Center
- Hawaii
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Medical Center
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Hawaii Cancer Care Inc - Waterfront Plaza
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Queen's Cancer Cenrer - POB I
  - Honolulu, Hawaii, Forenede Stater, 96813
    - Straub Clinic and Hospital
  - Honolulu, Hawaii, Forenede Stater, 96817
    - Queen's Cancer Center - Kuakini
  - Honolulu, Hawaii, Forenede Stater, 96819
    - Kaiser Permanente Moanalua Medical Center
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Hawaii Cancer Care - Westridge
  - ‘Aiea, Hawaii, Forenede Stater, 96701
    - Pali Momi Medical Center
- Idaho
  - Boise, Idaho, Forenede Stater, 83706
    - Saint Alphonsus Cancer Care Center-Boise
  - Boise, Idaho, Forenede Stater, 83712
    - Saint Luke's Cancer Institute - Boise
  - Caldwell, Idaho, Forenede Stater, 83605
    - Saint Alphonsus Cancer Care Center-Caldwell
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Health - Coeur d'Alene
  - Fruitland, Idaho, Forenede Stater, 83619
    - Saint Luke's Cancer Institute - Fruitland
  - Meridian, Idaho, Forenede Stater, 83642
    - Saint Luke's Cancer Institute - Meridian
  - Nampa, Idaho, Forenede Stater, 83686
    - Saint Luke's Cancer Institute - Nampa
  - Nampa, Idaho, Forenede Stater, 83687
    - Saint Alphonsus Cancer Care Center-Nampa
  - Post Falls, Idaho, Forenede Stater, 83854
    - Kootenai Clinic Cancer Services - Post Falls
  - Sandpoint, Idaho, Forenede Stater, 83864
    - Kootenai Cancer Clinic
  - Twin Falls, Idaho, Forenede Stater, 83301
    - Saint Luke's Cancer Institute - Twin Falls
- Illinois
  - Aurora, Illinois, Forenede Stater, 60504
    - Rush - Copley Medical Center
  - Barrington, Illinois, Forenede Stater, 60010
    - Advocate Good Shepherd Hospital
  - Bloomington, Illinois, Forenede Stater, 61704
    - Illinois CancerCare-Bloomington
  - Canton, Illinois, Forenede Stater, 61520
    - Illinois CancerCare-Canton
  - Carthage, Illinois, Forenede Stater, 62321
    - Illinois CancerCare-Carthage
  - Chicago, Illinois, Forenede Stater, 60611
    - Northwestern University
  - Chicago, Illinois, Forenede Stater, 60612
    - University of Illinois
  - Chicago, Illinois, Forenede Stater, 60625
    - Swedish Covenant Hospital
  - Chicago, Illinois, Forenede Stater, 60657
    - Advocate Illinois Masonic Medical Center
  - Crystal Lake, Illinois, Forenede Stater, 60014
    - AMG Crystal Lake - Oncology
  - Danville, Illinois, Forenede Stater, 61832
    - Carle at The Riverfront
  - DeKalb, Illinois, Forenede Stater, 60115
    - Northwestern Medicine Cancer Center Kishwaukee
  - Decatur, Illinois, Forenede Stater, 62526
    - Decatur Memorial Hospital
  - Decatur, Illinois, Forenede Stater, 62526
    - Cancer Care Specialists of Illinois - Decatur
  - Dixon, Illinois, Forenede Stater, 61021
    - Illinois CancerCare-Dixon
  - Downers Grove, Illinois, Forenede Stater, 60515
    - Advocate Good Samaritan Hospital
  - Effingham, Illinois, Forenede Stater, 62401
    - Crossroads Cancer Center
  - Effingham, Illinois, Forenede Stater, 62401
    - Carle Physician Group-Effingham
  - Elgin, Illinois, Forenede Stater, 60123
    - Advocate Sherman Hospital
  - Eureka, Illinois, Forenede Stater, 61530
    - Illinois CancerCare-Eureka
  - Evanston, Illinois, Forenede Stater, 60201
    - NorthShore University HealthSystem-Evanston Hospital
  - Galesburg, Illinois, Forenede Stater, 61401
    - Illinois CancerCare-Galesburg
  - Geneva, Illinois, Forenede Stater, 60134
    - Northwestern Medicine Cancer Center Delnor
  - Glenview, Illinois, Forenede Stater, 60026
    - NorthShore University HealthSystem-Glenbrook Hospital
  - Hazel Crest, Illinois, Forenede Stater, 60429
    - Advocate South Suburban Hospital
  - Highland Park, Illinois, Forenede Stater, 60035
    - NorthShore University HealthSystem-Highland Park Hospital
  - Hines, Illinois, Forenede Stater, 60141
    - Edward Hines Jr VA Hospital
  - Kewanee, Illinois, Forenede Stater, 61443
    - Illinois CancerCare-Kewanee Clinic
  - Lake Forest, Illinois, Forenede Stater, 60045
    - Northwestern Medicine Lake Forest Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - Condell Memorial Hospital
  - Libertyville, Illinois, Forenede Stater, 60048
    - AMG Libertyville - Oncology
  - Macomb, Illinois, Forenede Stater, 61455
    - Illinois CancerCare-Macomb
  - Mattoon, Illinois, Forenede Stater, 61938
    - Carle Physician Group-Mattoon/Charleston
  - Maywood, Illinois, Forenede Stater, 60153
    - Loyola University Medical Center
  - O'Fallon, Illinois, Forenede Stater, 62269
    - Cancer Care Center of O'Fallon
  - Oak Lawn, Illinois, Forenede Stater, 60453-2699
    - Advocate Christ Medical Center
  - Orland Park, Illinois, Forenede Stater, 60462
    - Northwestern Medicine Orland Park
  - Ottawa, Illinois, Forenede Stater, 61350
    - Illinois CancerCare-Ottawa Clinic
  - Park Ridge, Illinois, Forenede Stater, 60068
    - Advocate Lutheran General Hospital
  - Pekin, Illinois, Forenede Stater, 61554
    - Illinois CancerCare-Pekin
  - Peoria, Illinois, Forenede Stater, 61615
    - Illinois CancerCare-Peoria
  - Peru, Illinois, Forenede Stater, 61354
    - Illinois CancerCare-Peru
  - Princeton, Illinois, Forenede Stater, 61356
    - Illinois CancerCare-Princeton
  - Shiloh, Illinois, Forenede Stater, 62269
    - Memorial Hospital East
  - Springfield, Illinois, Forenede Stater, 62781
    - Memorial Medical Center
  - Springfield, Illinois, Forenede Stater, 62702
    - Southern Illinois University School of Medicine
  - Springfield, Illinois, Forenede Stater, 62702
    - Springfield Clinic
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Cancer Center
  - Warrenville, Illinois, Forenede Stater, 60555
    - Northwestern Medicine Cancer Center Warrenville
  - Washington, Illinois, Forenede Stater, 61571
    - Illinois CancerCare - Washington
  - Yorkville, Illinois, Forenede Stater, 60560
    - Rush-Copley Healthcare Center
- Indiana
  - Crown Point, Indiana, Forenede Stater, 46307
    - Northwest Cancer Center - Main Campus
  - Dyer, Indiana, Forenede Stater, 46311
    - Northwest Oncology LLC
  - Hobart, Indiana, Forenede Stater, 46342
    - Northwest Cancer Center - Hobart
  - Hobart, Indiana, Forenede Stater, 46342
    - Saint Mary Medical Center
  - Indianapolis, Indiana, Forenede Stater, 46312
    - Saint Catherine Hospital
  - Munster, Indiana, Forenede Stater, 46321
    - The Community Hospital
  - Munster, Indiana, Forenede Stater, 46321
    - Women's Diagnostic Center - Munster
  - South Bend, Indiana, Forenede Stater, 46601
    - Memorial Hospital of South Bend
  - Valparaiso, Indiana, Forenede Stater, 46383
    - Northwest Cancer Center - Valparaiso
- Iowa
  - Bettendorf, Iowa, Forenede Stater, 52722
    - University of Iowa Healthcare Cancer Services Quad Cities
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Mercy Hospital
  - Cedar Rapids, Iowa, Forenede Stater, 52403
    - Oncology Associates at Mercy Medical Center
  - Des Moines, Iowa, Forenede Stater, 50314
    - Mercy Medical Center - Des Moines
  - Des Moines, Iowa, Forenede Stater, 50309
    - Medical Oncology and Hematology Associates-Des Moines
- Kansas
  - Hays, Kansas, Forenede Stater, 67601
    - HaysMed University of Kansas Health System
  - Lawrence, Kansas, Forenede Stater, 66044
    - Lawrence Memorial Hospital
  - Olathe, Kansas, Forenede Stater, 66061
    - Olathe Health Cancer Center
  - Pittsburg, Kansas, Forenede Stater, 66762
    - Freeman Physician Group of Pittsburg
  - Salina, Kansas, Forenede Stater, 67401
    - Salina Regional Health Center
  - Topeka, Kansas, Forenede Stater, 66606
    - University of Kansas Health System Saint Francis Campus
  - Wichita, Kansas, Forenede Stater, 67214
    - Ascension Via Christi Hospitals Wichita
- Kentucky
  - Ashland, Kentucky, Forenede Stater, 41101
    - King's Daughter's Medical Center
  - Lexington, Kentucky, Forenede Stater, 40536
    - University of Kentucky/Markey Cancer Center
  - Owensboro, Kentucky, Forenede Stater, 42303
    - Owensboro Health Mitchell Memorial Cancer Center
- Louisiana
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Louisiana Hematology Oncology Associates LLC
  - Baton Rouge, Louisiana, Forenede Stater, 70809
    - Mary Bird Perkins Cancer Center
  - Houma, Louisiana, Forenede Stater, 70360
    - Terrebonne General Medical Center
  - New Orleans, Louisiana, Forenede Stater, 70112
    - University Medical Center New Orleans
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21215
    - Sinai Hospital of Baltimore
  - Baltimore, Maryland, Forenede Stater, 21204
    - Greater Baltimore Medical Center
  - Baltimore, Maryland, Forenede Stater, 21244
    - Kaiser Permanente-Woodlawn Medical Center
  - Bethesda, Maryland, Forenede Stater, 20889-5600
    - Walter Reed National Military Medical Center
  - Cumberland, Maryland, Forenede Stater, 21502
    - UPMC Western Maryland
  - Gaithersburg, Maryland, Forenede Stater, 20879
    - Kaiser Permanente-Gaithersburg Medical Center
  - Largo, Maryland, Forenede Stater, 20774
    - Kaiser Permanente - Largo Medical Center
  - Lutherville, Maryland, Forenede Stater, 21093
    - Kaiser Permanente Lutherville - Timonium Medical Center
  - Westminster, Maryland, Forenede Stater, 21157
    - William E Kahlert Regional Cancer Center/Sinai Hospital
- Massachusetts
  - Beverly, Massachusetts, Forenede Stater, 01915
    - Beverly Hospital
  - Boston, Massachusetts, Forenede Stater, 02118
    - Boston Medical Center
  - Burlington, Massachusetts, Forenede Stater, 01805
    - Lahey Hospital and Medical Center
  - Gloucester, Massachusetts, Forenede Stater, 01930
    - Addison Gilbert Hospital
  - Peabody, Massachusetts, Forenede Stater, 01960
    - Lahey Medical Center-Peabody
  - Springfield, Massachusetts, Forenede Stater, 01199
    - Baystate Medical Center
  - Winchester, Massachusetts, Forenede Stater, 01890
    - Winchester Hospital
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan Comprehensive Cancer Center
  - Ann Arbor, Michigan, Forenede Stater, 48106
    - Saint Joseph Mercy Hospital
  - Battle Creek, Michigan, Forenede Stater, 49017
    - Bronson Battle Creek
  - Brighton, Michigan, Forenede Stater, 48114
    - Saint Joseph Mercy Brighton
  - Brighton, Michigan, Forenede Stater, 48114
    - Trinity Health IHA Medical Group Hematology Oncology - Brighton
  - Canton, Michigan, Forenede Stater, 48188
    - Saint Joseph Mercy Canton
  - Canton, Michigan, Forenede Stater, 48188
    - Trinity Health IHA Medical Group Hematology Oncology - Canton
  - Chelsea, Michigan, Forenede Stater, 48118
    - Saint Joseph Mercy Chelsea
  - Chelsea, Michigan, Forenede Stater, 48118
    - Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
  - Detroit, Michigan, Forenede Stater, 48236
    - Ascension Saint John Hospital
  - East China, Michigan, Forenede Stater, 48054
    - Great Lakes Cancer Management Specialists-Doctors Park
  - Escanaba, Michigan, Forenede Stater, 49829
    - Green Bay Oncology - Escanaba
  - Flint, Michigan, Forenede Stater, 48503
    - Hurley Medical Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Cancer and Blood Disease Treatment Center
  - Flint, Michigan, Forenede Stater, 48503
    - Genesee Hematology Oncology PC
  - Flint, Michigan, Forenede Stater, 48503
    - Genesys Hurley Cancer Institute
  - Grand Rapids, Michigan, Forenede Stater, 49503
    - Spectrum Health at Butterworth Campus
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
  - Grosse Pointe Woods, Michigan, Forenede Stater, 48236
    - Michigan Breast Specialists-Grosse Pointe Woods
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - West Michigan Cancer Center
  - Kalamazoo, Michigan, Forenede Stater, 49007
    - Bronson Methodist Hospital
  - Kalamazoo, Michigan, Forenede Stater, 49048
    - Borgess Medical Center
  - Kalamazoo, Michigan, Forenede Stater, 49009
    - Ascension Borgess Cancer Center
  - Lansing, Michigan, Forenede Stater, 48912
    - Sparrow Hospital
  - Livonia, Michigan, Forenede Stater, 48154
    - Trinity Health Saint Mary Mercy Livonia Hospital
  - Macomb, Michigan, Forenede Stater, 48044
    - Great Lakes Cancer Management Specialists-Macomb Medical Campus
  - Macomb, Michigan, Forenede Stater, 48044
    - Michigan Breast Specialists-Macomb Township
  - Muskegon, Michigan, Forenede Stater, 49444
    - Trinity Health Muskegon Hospital
  - Norton Shores, Michigan, Forenede Stater, 49444
    - Cancer and Hematology Centers of Western Michigan - Norton Shores
  - Pontiac, Michigan, Forenede Stater, 48341
    - Saint Joseph Mercy Oakland
  - Reed City, Michigan, Forenede Stater, 49677
    - Corewell Health Reed City Hospital
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Lakeland Medical Center Saint Joseph
  - Saint Joseph, Michigan, Forenede Stater, 49085
    - Marie Yeager Cancer Center
  - Sterling Heights, Michigan, Forenede Stater, 48312
    - Bhadresh Nayak MD PC-Sterling Heights
  - Traverse City, Michigan, Forenede Stater, 49684
    - Munson Medical Center
  - Warren, Michigan, Forenede Stater, 48093
    - Saint John Macomb-Oakland Hospital
  - Warren, Michigan, Forenede Stater, 48088
    - Advanced Breast Care Center PLLC
  - Warren, Michigan, Forenede Stater, 48093
    - Great Lakes Cancer Management Specialists-Macomb Professional Building
  - Warren, Michigan, Forenede Stater, 48093
    - Macomb Hematology Oncology PC
  - Warren, Michigan, Forenede Stater, 48093
    - Michigan Breast Specialists-Warren
  - Wyoming, Michigan, Forenede Stater, 49519
    - University of Michigan Health - West
  - Ypsilanti, Michigan, Forenede Stater, 48197
    - Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
  - Ypsilanti, Michigan, Forenede Stater, 48106
    - Huron Gastroenterology PC
- Minnesota
  - Bemidji, Minnesota, Forenede Stater, 56601
    - Sanford Joe Lueken Cancer Center
  - Coon Rapids, Minnesota, Forenede Stater, 55433
    - Mercy Hospital
  - Edina, Minnesota, Forenede Stater, 55435
    - Fairview Southdale Hospital
  - Maple Grove, Minnesota, Forenede Stater, 55369
    - Fairview Clinics and Surgery Center Maple Grove
  - Minneapolis, Minnesota, Forenede Stater, 55415
    - Hennepin County Medical Center
  - Minneapolis, Minnesota, Forenede Stater, 55407
    - Abbott-Northwestern Hospital
  - New Ulm, Minnesota, Forenede Stater, 56073
    - New Ulm Medical Center
  - Saint Louis Park, Minnesota, Forenede Stater, 55416
    - Park Nicollet Clinic - Saint Louis Park
  - Saint Paul, Minnesota, Forenede Stater, 55101
    - Regions Hospital
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - United Hospital
  - Willmar, Minnesota, Forenede Stater, 56201
    - Rice Memorial Hospital
- Mississippi
  - Columbus, Mississippi, Forenede Stater, 39705
    - Baptist Memorial Hospital and Cancer Center-Golden Triangle
  - Grenada, Mississippi, Forenede Stater, 38901
    - Baptist Cancer Center-Grenada
  - Gulfport, Mississippi, Forenede Stater, 39502
    - Gulfport Memorial Hospital
  - New Albany, Mississippi, Forenede Stater, 38652
    - Baptist Memorial Hospital and Cancer Center-Union County
  - Oxford, Mississippi, Forenede Stater, 38655
    - Baptist Memorial Hospital and Cancer Center-Oxford
  - Southhaven, Mississippi, Forenede Stater, 38671
    - Baptist Memorial Hospital and Cancer Center-Desoto
- Missouri
  - Cape Girardeau, Missouri, Forenede Stater, 63703
    - Saint Francis Medical Center
  - City of Saint Peters, Missouri, Forenede Stater, 63376
    - Siteman Cancer Center at Saint Peters Hospital
  - Creve Coeur, Missouri, Forenede Stater, 63141
    - Siteman Cancer Center at West County Hospital
  - Farmington, Missouri, Forenede Stater, 63640
    - Parkland Health Center - Farmington
  - Kansas City, Missouri, Forenede Stater, 64128
    - Kansas City Veterans Affairs Medical Center
  - Kansas City, Missouri, Forenede Stater, 64111
    - Saint Luke's Hospital of Kansas City
  - Kansas City, Missouri, Forenede Stater, 64108
    - Truman Medical Centers
  - Lee's Summit, Missouri, Forenede Stater, 64086
    - Saint Luke's East - Lee's Summit
  - Sainte Genevieve, Missouri, Forenede Stater, 63670
    - Sainte Genevieve County Memorial Hospital
  - Springfield, Missouri, Forenede Stater, 65804
    - Mercy Hospital Springfield
  - St Louis, Missouri, Forenede Stater, 63110
    - Washington University School of Medicine
  - St Louis, Missouri, Forenede Stater, 63129
    - Siteman Cancer Center-South County
  - St Louis, Missouri, Forenede Stater, 63136
    - Siteman Cancer Center at Christian Hospital
  - St Louis, Missouri, Forenede Stater, 63131
    - Missouri Baptist Medical Center
  - St Louis, Missouri, Forenede Stater, 63141
    - Mercy Hospital Saint Louis
  - St Louis, Missouri, Forenede Stater, 63128
    - Mercy Hospital South
  - St Louis, Missouri, Forenede Stater, 63125
    - Veteran's Affairs Medical Center - Saint Louis
  - Sullivan, Missouri, Forenede Stater, 63080
    - Missouri Baptist Sullivan Hospital
  - Sunset Hills, Missouri, Forenede Stater, 63127
    - BJC Outpatient Center at Sunset Hills
- Montana
  - Anaconda, Montana, Forenede Stater, 59711
    - Community Hospital of Anaconda
  - Billings, Montana, Forenede Stater, 59101
    - Billings Clinic Cancer Center
  - Bozeman, Montana, Forenede Stater, 59715
    - Bozeman Deaconess Hospital
  - Great Falls, Montana, Forenede Stater, 59405
    - Benefis Healthcare- Sletten Cancer Institute
  - Kalispell, Montana, Forenede Stater, 59901
    - Kalispell Regional Medical Center
  - Missoula, Montana, Forenede Stater, 59804
    - Community Medical Hospital
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - OptumCare Cancer Care at Charleston
  - Las Vegas, Nevada, Forenede Stater, 89148
    - OptumCare Cancer Care at Fort Apache
  - Reno, Nevada, Forenede Stater, 89502
    - Renown Regional Medical Center
- New Hampshire
  - Lebanon, New Hampshire, Forenede Stater, 03756
    - Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
- New Jersey
  - Camden, New Jersey, Forenede Stater, 08103
    - Cooper Hospital University Medical Center
  - Elizabeth, New Jersey, Forenede Stater, 07207
    - Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
  - Hamilton, New Jersey, Forenede Stater, 08690
    - The Cancer Institute of New Jersey Hamilton
  - Jersey City, New Jersey, Forenede Stater, 07302
    - Jersey City Medical Center
  - Lakewood, New Jersey, Forenede Stater, 08701
    - Monmouth Medical Center Southern Campus
  - Livingston, New Jersey, Forenede Stater, 07039
    - Saint Barnabas Medical Center
  - Long Branch, New Jersey, Forenede Stater, 07740
    - Monmouth Medical Center
  - Moorestown, New Jersey, Forenede Stater, 08057
    - Virtua Samson Cancer Center
  - New Brunswick, New Jersey, Forenede Stater, 08903
    - Rutgers Cancer Institute of New Jersey
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Somerville, New Jersey, Forenede Stater, 08876
    - Robert Wood Johnson University Hospital Somerset
  - Toms River, New Jersey, Forenede Stater, 08755
    - Community Medical Center
  - Voorhees Township, New Jersey, Forenede Stater, 08043
    - MD Anderson Cancer Center at Cooper-Voorhees
  - Voorhees Township, New Jersey, Forenede Stater, 08043
    - Virtua Voorhees
- New Mexico
  - Albuquerque, New Mexico, Forenede Stater, 87102
    - University of New Mexico Cancer Center
- New York
  - Elmira, New York, Forenede Stater, 14905
    - Arnot Ogden Medical Center/Falck Cancer Center
  - Middletown, New York, Forenede Stater, 10940
    - Garnet Health Medical Center
  - New York, New York, Forenede Stater, 10029
    - Mount Sinai Hospital
  - New York, New York, Forenede Stater, 10011
    - Mount Sinai Chelsea
  - Oswego, New York, Forenede Stater, 13126
    - Upstate Cancer Center at Oswego
  - Rochester, New York, Forenede Stater, 14642
    - University of Rochester
  - Stony Brook, New York, Forenede Stater, 11794
    - Stony Brook University Medical Center
  - Syracuse, New York, Forenede Stater, 13210
    - State University of New York Upstate Medical University
  - Syracuse, New York, Forenede Stater, 13215
    - SUNY Upstate Medical Center-Community Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Einstein Campus
  - The Bronx, New York, Forenede Stater, 10467
    - Montefiore Medical Center - Moses Campus
  - The Bronx, New York, Forenede Stater, 10461
    - Montefiore Medical Center-Weiler Hospital
  - Verona, New York, Forenede Stater, 13478
    - Upstate Cancer Center at Verona
  - Webster, New York, Forenede Stater, 14580
    - Wilmot Cancer Institute at Webster
- North Carolina
  - Albemarle, North Carolina, Forenede Stater, 28002
    - Atrium Health Stanly/LCI-Albemarle
  - Asheville, North Carolina, Forenede Stater, 28803
    - AdventHealth Infusion Center Asheville
  - Cary, North Carolina, Forenede Stater, 27518
    - Rex Hematology Oncology Associates-Cary
  - Chapel Hill, North Carolina, Forenede Stater, 27599
    - UNC Lineberger Comprehensive Cancer Center
  - Charlotte, North Carolina, Forenede Stater, 28203
    - Carolinas Medical Center/Levine Cancer Institute
  - Charlotte, North Carolina, Forenede Stater, 28210
    - Atrium Health Pineville/LCI-Pineville
  - Charlotte, North Carolina, Forenede Stater, 28262
    - Atrium Health University City/LCI-University
  - Charlotte, North Carolina, Forenede Stater, 28211
    - Levine Cancer Institute-SouthPark
  - Charlotte, North Carolina, Forenede Stater, 28277
    - Levine Cancer Institute-Ballantyne
  - Clinton, North Carolina, Forenede Stater, 28328
    - Southeastern Medical Oncology Center-Clinton
  - Clyde, North Carolina, Forenede Stater, 28721
    - AdventHealth Infusion Center Haywood
  - Concord, North Carolina, Forenede Stater, 28025
    - Atrium Health Cabarrus/LCI-Concord
  - Durham, North Carolina, Forenede Stater, 27710
    - Duke University Medical Center
  - Forest City, North Carolina, Forenede Stater, 28043
    - Levine Cancer Institute - Rutherford
  - Garner, North Carolina, Forenede Stater, 27529
    - Rex Hematology Oncology Associates-Garner
  - Gastonia, North Carolina, Forenede Stater, 28054
    - Levine Cancer Institute-Gaston
  - Goldsboro, North Carolina, Forenede Stater, 27534
    - Southeastern Medical Oncology Center-Goldsboro
  - Hendersonville, North Carolina, Forenede Stater, 28792
    - AdventHealth Hendersonville
  - Jacksonville, North Carolina, Forenede Stater, 28546
    - Southeastern Medical Oncology Center-Jacksonville
  - Lincolnton, North Carolina, Forenede Stater, 28092
    - Atrium Health Lincoln/LCI-Lincolnton
  - Matthews, North Carolina, Forenede Stater, 28104
    - Levine Cancer Institute - Union West
  - Monroe, North Carolina, Forenede Stater, 28112
    - Atrium Health Union/LCI-Union
  - Pinehurst, North Carolina, Forenede Stater, 28374
    - FirstHealth of the Carolinas-Moore Regional Hospital
  - Raleigh, North Carolina, Forenede Stater, 27607
    - UNC Rex Healthcare
  - Raleigh, North Carolina, Forenede Stater, 27614
    - UNC Rex Cancer Center of Wakefield
  - Shelby, North Carolina, Forenede Stater, 28150
    - Atrium Health Cleveland/LCI-Cleveland
  - Weaverville, North Carolina, Forenede Stater, 28787
    - AdventHealth Infusion Center Weaverville
- North Dakota
  - Bismarck, North Dakota, Forenede Stater, 58501
    - Sanford Bismarck Medical Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Roger Maris Cancer Center
  - Fargo, North Dakota, Forenede Stater, 58122
    - Sanford Broadway Medical Center
- Ohio
  - Akron, Ohio, Forenede Stater, 44307
    - Cleveland Clinic Akron General
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Health System - Akron Campus
  - Barberton, Ohio, Forenede Stater, 44203
    - Summa Health System - Barberton Campus
  - Belpre, Ohio, Forenede Stater, 45714
    - Strecker Cancer Center-Belpre
  - Canton, Ohio, Forenede Stater, 44708
    - Cleveland Clinic Mercy Hospital
  - Canton, Ohio, Forenede Stater, 44710
    - Aultman Health Foundation
  - Centerville, Ohio, Forenede Stater, 45459
    - Miami Valley Hospital South
  - Chillicothe, Ohio, Forenede Stater, 45601
    - Adena Regional Medical Center
  - Cleveland, Ohio, Forenede Stater, 44195
    - Cleveland Clinic Foundation
  - Cleveland, Ohio, Forenede Stater, 44111
    - Cleveland Clinic Cancer Center/Fairview Hospital
  - Columbus, Ohio, Forenede Stater, 43219
    - The Mark H Zangmeister Center
  - Columbus, Ohio, Forenede Stater, 43213
    - Mount Carmel East Hospital
  - Dayton, Ohio, Forenede Stater, 45409
    - Miami Valley Hospital
  - Dayton, Ohio, Forenede Stater, 45415
    - Dayton Physician LLC-Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45415
    - Miami Valley Hospital North
  - Dayton, Ohio, Forenede Stater, 45409
    - Dayton Blood and Cancer Center
  - Franklin, Ohio, Forenede Stater, 45005-1066
    - Atrium Medical Center-Middletown Regional Hospital
  - Greenville, Ohio, Forenede Stater, 45331
    - Miami Valley Cancer Care and Infusion
  - Independence, Ohio, Forenede Stater, 44131
    - Cleveland Clinic Cancer Center Independence
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Lancaster, Ohio, Forenede Stater, 43130
    - Fairfield Medical Center
  - Mansfield, Ohio, Forenede Stater, 44906
    - Cleveland Clinic Cancer Center Mansfield
  - Marysville, Ohio, Forenede Stater, 43040
    - Memorial Hospital
  - Mayfield Heights, Ohio, Forenede Stater, 44124
    - Hillcrest Hospital Cancer Center
  - Medina, Ohio, Forenede Stater, 44256
    - Summa Health Medina Medical Center
  - Mount Vernon, Ohio, Forenede Stater, 43050
    - Knox Community Hospital
  - Newark, Ohio, Forenede Stater, 43055
    - Licking Memorial Hospital
  - Perrysburg, Ohio, Forenede Stater, 43551
    - Mercy Health Perrysburg Cancer Center
  - Portsmouth, Ohio, Forenede Stater, 45662
    - Southern Ohio Medical Center
  - Sandusky, Ohio, Forenede Stater, 44870
    - North Coast Cancer Care
  - Springfield, Ohio, Forenede Stater, 45505
    - Springfield Regional Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - Springfield Regional Cancer Center
  - Steubenville, Ohio, Forenede Stater, 43952
    - Trinity's Tony Teramana Cancer Center
  - Strongsville, Ohio, Forenede Stater, 44136
    - Cleveland Clinic Cancer Center Strongsville
  - Toledo, Ohio, Forenede Stater, 43623
    - Mercy Health - Saint Anne Hospital
  - Toledo, Ohio, Forenede Stater, 43623
    - Toledo Clinic Cancer Centers-Toledo
  - Troy, Ohio, Forenede Stater, 45373
    - Upper Valley Medical Center
  - Warrensville Heights, Ohio, Forenede Stater, 44122
    - South Pointe Hospital
  - Westerville, Ohio, Forenede Stater, 43081
    - Saint Ann's Hospital
  - Wooster, Ohio, Forenede Stater, 44691
    - Cleveland Clinic Wooster Family Health and Surgery Center
  - Zanesville, Ohio, Forenede Stater, 43701
    - Genesis Healthcare System Cancer Care Center
- Oklahoma
  - Oklahoma City, Oklahoma, Forenede Stater, 73104
    - University of Oklahoma Health Sciences Center
  - Oklahoma City, Oklahoma, Forenede Stater, 73120
    - Mercy Hospital Oklahoma City
- Oregon
  - Gresham, Oregon, Forenede Stater, 97030
    - Legacy Mount Hood Medical Center
  - Newberg, Oregon, Forenede Stater, 97132
    - Providence Newberg Medical Center
  - Ontario, Oregon, Forenede Stater, 97914
    - Saint Alphonsus Medical Center-Ontario
  - Oregon City, Oregon, Forenede Stater, 97045
    - Providence Willamette Falls Medical Center
  - Portland, Oregon, Forenede Stater, 97239
    - Oregon Health and Science University
  - Portland, Oregon, Forenede Stater, 97210
    - Legacy Good Samaritan Hospital and Medical Center
  - Portland, Oregon, Forenede Stater, 97213
    - Providence Portland Medical Center
  - Portland, Oregon, Forenede Stater, 97225
    - Providence Saint Vincent Medical Center
  - Portland, Oregon, Forenede Stater, 97227
    - Kaiser Permanente Northwest
  - Tualatin, Oregon, Forenede Stater, 97062
    - Legacy Meridian Park Hospital
- Pennsylvania
  - Allentown, Pennsylvania, Forenede Stater, 18103
    - Lehigh Valley Hospital-Cedar Crest
  - Altoona, Pennsylvania, Forenede Stater, 16601
    - UPMC Altoona
  - Beaver, Pennsylvania, Forenede Stater, 15009
    - UPMC-Heritage Valley Health System Beaver
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Lehigh Valley Hospital - Muhlenberg
  - Bryn Mawr, Pennsylvania, Forenede Stater, 19010
    - Bryn Mawr Hospital
  - Butler, Pennsylvania, Forenede Stater, 16001
    - UPMC Hillman Cancer Center at Butler Health System
  - Camp Hill, Pennsylvania, Forenede Stater, 17011
    - UPMC Camp Hill
  - Carlisle, Pennsylvania, Forenede Stater, 17015
    - Carlisle Regional Cancer Center
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - WellSpan Medical Oncology and Hematology
  - Danville, Pennsylvania, Forenede Stater, 17822
    - Geisinger Medical Center
  - East Stroudsburg, Pennsylvania, Forenede Stater, 18301
    - Pocono Medical Center
  - Ephrata, Pennsylvania, Forenede Stater, 17522
    - Ephrata Cancer Center
  - Erie, Pennsylvania, Forenede Stater, 16505
    - UPMC Hillman Cancer Center Erie
  - Farrell, Pennsylvania, Forenede Stater, 16121
    - UPMC Cancer Center at UPMC Horizon
  - Gettysburg, Pennsylvania, Forenede Stater, 17325
    - Adams Cancer Center
  - Greensburg, Pennsylvania, Forenede Stater, 15601
    - UPMC Cancer Centers - Arnold Palmer Pavilion
  - Harrisburg, Pennsylvania, Forenede Stater, 17109
    - UPMC Pinnacle Cancer Center/Community Osteopathic Campus
  - Indiana, Pennsylvania, Forenede Stater, 15701
    - IRMC Cancer Center
  - Johnstown, Pennsylvania, Forenede Stater, 15901
    - UPMC-Johnstown/John P. Murtha Regional Cancer Center
  - Lancaster, Pennsylvania, Forenede Stater, 17601
    - Lancaster General Ann B Barshinger Cancer Institute
  - Lebanon, Pennsylvania, Forenede Stater, 17042
    - Sechler Family Cancer Center
  - McKeesport, Pennsylvania, Forenede Stater, 15132
    - UPMC Cancer Center at UPMC McKeesport
  - Mechanicsburg, Pennsylvania, Forenede Stater, 17050
    - UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
  - Media, Pennsylvania, Forenede Stater, 19063
    - Riddle Memorial Hospital
  - Monroeville, Pennsylvania, Forenede Stater, 15146
    - UPMC Hillman Cancer Center - Monroeville
  - Mount Pleasant, Pennsylvania, Forenede Stater, 15666
    - UPMC Hillman Cancer Center - Part of Frick Hospital
  - Natrona Heights, Pennsylvania, Forenede Stater, 15065
    - UPMC Cancer Center-Natrona Heights
  - New Castle, Pennsylvania, Forenede Stater, 16105
    - UPMC Hillman Cancer Center - New Castle
  - North Huntingdon, Pennsylvania, Forenede Stater, 15642
    - Arnold Palmer Cancer Center Medical Oncology Norwin
  - Paoli, Pennsylvania, Forenede Stater, 19301
    - Paoli Memorial Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19107
    - Thomas Jefferson University Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19114
    - Jefferson Torresdale Hospital
  - Philadelphia, Pennsylvania, Forenede Stater, 19140
    - Temple University Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15232
    - University of Pittsburgh Cancer Institute (UPCI)
  - Pittsburgh, Pennsylvania, Forenede Stater, 15215
    - UPMC-Saint Margaret
  - Pittsburgh, Pennsylvania, Forenede Stater, 15237
    - UPMC-Passavant Hospital
  - Pittsburgh, Pennsylvania, Forenede Stater, 15243
    - UPMC-Saint Clair Hospital Cancer Center
  - Pittsburgh, Pennsylvania, Forenede Stater, 15219
    - UPMC-Mercy Hospital
  - Scranton, Pennsylvania, Forenede Stater, 18510
    - Community Medical Center
  - Seneca, Pennsylvania, Forenede Stater, 16346
    - UPMC Cancer Center at UPMC Northwest
  - Uniontown, Pennsylvania, Forenede Stater, 15401
    - UPMC Cancer Center-Uniontown
  - Washington, Pennsylvania, Forenede Stater, 15301
    - UPMC Cancer Center-Washington
  - West Chester, Pennsylvania, Forenede Stater, 19380
    - Chester County Hospital
  - Wilkes-Barre, Pennsylvania, Forenede Stater, 18711
    - Geisinger Wyoming Valley/Henry Cancer Center
  - Williamsport, Pennsylvania, Forenede Stater, 17754
    - Divine Providence Hospital
  - Willow Grove, Pennsylvania, Forenede Stater, 19090
    - Asplundh Cancer Pavilion
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Medical Center
  - York, Pennsylvania, Forenede Stater, 17403
    - WellSpan Health-York Cancer Center
  - York, Pennsylvania, Forenede Stater, 17403
    - Cancer Care Associates of York
  - York, Pennsylvania, Forenede Stater, 17408
    - UPMC Memorial
- Rhode Island
  - Westerly, Rhode Island, Forenede Stater, 02891
    - Smilow Cancer Hospital Care Center - Westerly
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health Cancer Center
  - Bluffton, South Carolina, Forenede Stater, 29910
    - Saint Joseph's/Candler - Bluffton Campus
  - Charleston, South Carolina, Forenede Stater, 29425
    - Medical University of South Carolina
  - Florence, South Carolina, Forenede Stater, 29506
    - McLeod Regional Medical Center
  - Georgetown, South Carolina, Forenede Stater, 29440
    - Tidelands Georgetown Memorial Hospital
  - Greer, South Carolina, Forenede Stater, 29651
    - Gibbs Cancer Center-Pelham
  - Hilton Head Island, South Carolina, Forenede Stater, 29926-3827
    - South Carolina Cancer Specialists PC
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - Levine Cancer Institute-Rock Hill
  - Spartanburg, South Carolina, Forenede Stater, 29303
    - Spartanburg Medical Center
- South Dakota
  - Sioux Falls, South Dakota, Forenede Stater, 57117-5134
    - Sanford USD Medical Center - Sioux Falls
  - Sioux Falls, South Dakota, Forenede Stater, 57104
    - Sanford Cancer Center Oncology Clinic
- Tennessee
  - Collierville, Tennessee, Forenede Stater, 38017
    - Baptist Memorial Hospital and Cancer Center-Collierville
  - Memphis, Tennessee, Forenede Stater, 38120
    - Baptist Memorial Hospital and Cancer Center-Memphis
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University/Ingram Cancer Center
- Texas
  - Amarillo, Texas, Forenede Stater, 79106
    - The Don and Sybil Harrington Cancer Center
  - Baytown, Texas, Forenede Stater, 77521
    - Houston Methodist San Jacinto Hospital
  - Dallas, Texas, Forenede Stater, 75216
    - Dallas VA Medical Center
  - Fort Worth, Texas, Forenede Stater, 76104
    - Tarrant County Hospital District/JPS Health Network
  - Houston, Texas, Forenede Stater, 77026-1967
    - Lyndon Baines Johnson General Hospital
  - Houston, Texas, Forenede Stater, 77030
    - Houston Methodist Hospital
  - Houston, Texas, Forenede Stater, 77070
    - Methodist Willowbrook Hospital
  - Sugar Land, Texas, Forenede Stater, 77479
    - Houston Methodist Sugar Land Hospital
- Utah
  - Salt Lake City, Utah, Forenede Stater, 84112
    - Huntsman Cancer Institute/University of Utah
- Vermont
  - Saint Johnsbury, Vermont, Forenede Stater, 05819
    - Norris Cotton Cancer Center-North
- Virginia
  - Charlottesville, Virginia, Forenede Stater, 22908
    - University of Virginia Cancer Center
  - Lynchburg, Virginia, Forenede Stater, 24501
    - Centra Lynchburg Hematology-Oncology Clinic Inc
  - McLean, Virginia, Forenede Stater, 22102
    - Kaiser Permanente Tysons Corner Medical Center
- Washington
  - Bellingham, Washington, Forenede Stater, 98225
    - PeaceHealth Saint Joseph Medical Center
  - Seattle, Washington, Forenede Stater, 98109
    - Fred Hutchinson Cancer Research Center
  - Seattle, Washington, Forenede Stater, 98195
    - University of Washington Medical Center - Montlake
  - Seattle, Washington, Forenede Stater, 98109
    - FHCC South Lake Union
  - Sedro-Woolley, Washington, Forenede Stater, 98284
    - PeaceHealth United General Medical Center
  - Tacoma, Washington, Forenede Stater, 98405
    - Northwest Medical Specialties PLLC
  - Vancouver, Washington, Forenede Stater, 98686
    - Legacy Salmon Creek Hospital
  - Vancouver, Washington, Forenede Stater, 98684
    - Legacy Cancer Institute Medical Oncology and Day Treatment
- West Virginia
  - Charleston, West Virginia, Forenede Stater, 25304
    - West Virginia University Charleston Division
  - Huntington, West Virginia, Forenede Stater, 25701
    - Edwards Comprehensive Cancer Center
  - Morgantown, West Virginia, Forenede Stater, 26506
    - West Virginia University Healthcare
  - Wheeling, West Virginia, Forenede Stater, 26003
    - Wheeling Hospital/Schiffler Cancer Center
- Wisconsin
  - Antigo, Wisconsin, Forenede Stater, 54409
    - Langlade Hospital and Cancer Center
  - Appleton, Wisconsin, Forenede Stater, 54911
    - ThedaCare Regional Cancer Center
  - Burlington, Wisconsin, Forenede Stater, 53105
    - Aurora Cancer Care-Southern Lakes VLCC
  - Eau Claire, Wisconsin, Forenede Stater, 54701
    - HSHS Sacred Heart Hospital
  - Germantown, Wisconsin, Forenede Stater, 53022
    - Aurora Health Care Germantown Health Center
  - Grafton, Wisconsin, Forenede Stater, 53024
    - Aurora Cancer Care-Grafton
  - Green Bay, Wisconsin, Forenede Stater, 54311
    - Aurora BayCare Medical Center
  - Green Bay, Wisconsin, Forenede Stater, 54301
    - Saint Vincent Hospital Cancer Center Green Bay
  - Green Bay, Wisconsin, Forenede Stater, 54303
    - Saint Vincent Hospital Cancer Center at Saint Mary's
  - Kenosha, Wisconsin, Forenede Stater, 53142
    - Aurora Cancer Care-Kenosha South
  - La Crosse, Wisconsin, Forenede Stater, 54601
    - Gundersen Lutheran Medical Center
  - Madison, Wisconsin, Forenede Stater, 53792
    - University of Wisconsin Carbone Cancer Center
  - Marinette, Wisconsin, Forenede Stater, 54143
    - Aurora Bay Area Medical Group-Marinette
  - Medford, Wisconsin, Forenede Stater, 54451
    - Aspirus Medford Hospital
  - Milwaukee, Wisconsin, Forenede Stater, 53209
    - Aurora Cancer Care-Milwaukee
  - Milwaukee, Wisconsin, Forenede Stater, 53215
    - Aurora Saint Luke's Medical Center
  - Milwaukee, Wisconsin, Forenede Stater, 53233
    - Aurora Sinai Medical Center
  - Mukwonago, Wisconsin, Forenede Stater, 53149
    - ProHealth D N Greenwald Center
  - Oconomowoc, Wisconsin, Forenede Stater, 53066
    - ProHealth Oconomowoc Memorial Hospital
  - Oconto Falls, Wisconsin, Forenede Stater, 54154
    - Saint Vincent Hospital Cancer Center at Oconto Falls
  - Oshkosh, Wisconsin, Forenede Stater, 54904
    - Vince Lombardi Cancer Clinic - Oshkosh
  - Racine, Wisconsin, Forenede Stater, 53406
    - Aurora Cancer Care-Racine
  - Rhinelander, Wisconsin, Forenede Stater, 54501
    - Ascension Saint Mary's Hospital
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Vince Lombardi Cancer Clinic-Sheboygan
  - Sheboygan, Wisconsin, Forenede Stater, 53081
    - Saint Vincent Hospital Cancer Center at Sheboygan
  - Stevens Point, Wisconsin, Forenede Stater, 54481
    - Ascension Saint Michael's Hospital
  - Sturgeon Bay, Wisconsin, Forenede Stater, 54235-1495
    - Saint Vincent Hospital Cancer Center at Sturgeon Bay
  - Summit, Wisconsin, Forenede Stater, 53066
    - Aurora Medical Center in Summit
  - Two Rivers, Wisconsin, Forenede Stater, 54241
    - Vince Lombardi Cancer Clinic-Two Rivers
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - UW Cancer Center at ProHealth Care
  - Waukesha, Wisconsin, Forenede Stater, 53188
    - ProHealth Waukesha Memorial Hospital
  - Wausau, Wisconsin, Forenede Stater, 54401
    - Aspirus Regional Cancer Center
  - Wauwatosa, Wisconsin, Forenede Stater, 53226
    - Aurora Cancer Care-Milwaukee West
  - West Allis, Wisconsin, Forenede Stater, 53227
    - Aurora West Allis Medical Center
  - Wisconsin Rapids, Wisconsin, Forenede Stater, 54494
    - Aspirus Cancer Care - Wisconsin Rapids

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Deltagerne skal have histologisk eller cytologisk bekræftet ikke-småcellet lungekræft (NSCLC), som er stadium IV eller tilbagevendende
Deltagerne skal have modtaget mindst én linje af anti-PD-1- eller anti-PD-L1-terapi for ethvert stadium af NSCLC. Anti-PD-1 eller anti-PD-L1 kan være givet alene eller i kombination med anden behandling
Deltagerne skal have oplevet sygdomsprogression (efter den behandlende læges mening) mere end (>) 84 dage efter påbegyndelse (cyklus 1 dag 1) af deres seneste anti-PD-1- eller PD-L1-behandling
Deltagere, der modtog anti-PD-1- eller anti-PD-L1-behandling for stadium IV eller tilbagevendende sygdom, skal have haft det bedste respons på anti-PD-1- eller anti-PD-L1-behandling med stabil, delvis respons eller fuldstændig respons ( efter den behandlende læges vurdering)
Deltagere, der modtog neoadjuverende, adjuverende og/eller konsoliderende anti-PD-1- eller anti-PD-L1-behandling som deres eneste linje af anti-PD-1- eller anti-PD-L1-terapi, skal have oplevet sygdomsprogression inden for (=<) 365 dage fra påbegyndelse (cyklus 1 dag 1) af anti-PD-1- eller PD-L1-behandling
Deltagerne skal have modtaget platinbaseret kemoterapi og oplevet sygdomsprogression (efter den behandlende læges mening) under eller efter dette regime
Deltagere med en kendt sensibiliserende mutation, for hvilken der findes en Food and Drug Administration (FDA)-godkendt målrettet behandling for NSCLC (f.eks. EGFR, ALK, ROS1, BRAF, RET, NTRK, KRAS, HER2 og MET sensibiliserende mutationer), skal have tidligere modtaget mindst én af de godkendte behandlinger. Forudgående målrettet terapi for deltagere med målrettede ændringer er tilladt, hvis alle andre berettigelseskriterier også er opfyldt
Deltagerne skal være >= 18 år
Deltagerne skal sikkert kunne modtage forsøgslægemiddelkombinationen og investigatorens valg af standardbehandlingsregimer i henhold til den(de) aktuelle FDA-godkendte indlægsseddel(er), behandlende investigators skøn og institutionelle retningslinjer
Deltagere skal have Zubrod præstationsstatus på 0-2

Ekskluderingskriterier:

Deltagerne må ikke have modtaget mere end én linje af anti-PD-1 eller anti-PD-L1 for stadium IV eller tilbagevendende sygdom
Deltagerne må ikke modtage eller planlægge at modtage en anden undersøgelsesterapi under undersøgelsesdeltagelsen

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Ingen (Åben etiket)

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Aktiv komparator: ARM A (standardbehandling kemoterapi) Patienter modtager kemoterapi efter standardbehandling på undersøgelse.	Medicin: Kemoterapi Modtag standardbehandling kemoterapi Andre navne: Chemo Kemoterapi (NOS) Kemoterapi, Kræft, Generelt
Eksperimentel: ARM B (ramucirumab, pembrolizumab) Patienterne får ramucirumab IV og pembrolizumab IV i undersøgelsen.	Biologisk: Pembrolizumab Givet IV Andre navne: Keytruda MK-3475 Lambrolizumab SCH 900475 Biologisk: Ramucirumab Givet IV Andre navne: LY3009806 IMC-1121B Cyramza Anti-VEGFR-2 fuldt humant monoklonalt antistof IMC-1121B

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Samlet overlevelse Tidsramme: Fra dato for randomisering til dato for død på grund af enhver årsag, vurderet op til 3 år	Vurderet hos deltagere med stadium IV eller tilbagevendende ikke-småcellet lungekræft med erhvervet resistens over for anti-PD-1 eller anti-PD-L1 terapi randomiseret til ramucirumab og pembrolizumab eller standardbehandling kemoterapi. Vil bruge en intention-to-treat-analyse, og sammenligningen vil blive udført ved hjælp af en stratificeret log-rank test. Fordelingen af den samlede overlevelse vil blive estimeret ved hjælp af metoden fra Kaplan-Meier, og en Cox proportional hazards model vil blive brugt til at estimere hazard ratios og tilhørende 95 % konfidensintervaller for at estimere behandlingseffekter.	Fra dato for randomisering til dato for død på grund af enhver årsag, vurderet op til 3 år

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Forekomst af højgradige (>= grad 3) bivirkninger Tidsramme: Op til 3 år	Uventede behandlingsrelaterede bivirkninger bestemt af den behandlende læge.	Op til 3 år

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

SWOG Cancer Research Network

Samarbejdspartnere

National Cancer Institute (NCI)

Eli Lilly and Company

Merck Sharp & Dohme LLC

Efterforskere

Ledende efterforsker: Karen L Reckamp, SWOG Cancer Research Network

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

14. marts 2023

Primær færdiggørelse (Faktiske)

26. november 2025

Studieafslutning (Anslået)

15. marts 2028

Datoer for studieregistrering

Først indsendt

21. november 2022

Først indsendt, der opfyldte QC-kriterier

21. november 2022

Først opslået (Faktiske)

1. december 2022

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

17. april 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

14. april 2026

Sidst verificeret

1. april 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

S2302 (Anden identifikator: CTEP)
U10CA180888 (U.S. NIH-bevilling/kontrakt)
NCI-2022-09319 (Registry Identifier: CTRP (Clinical Trial Reporting Program))

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

Kliniske forsøg med Pembrolizumab

Universitair Ziekenhuis Brussel

Rekruttering

En fase 2 klinisk undersøgelse, der evaluerer effektiviteten af en enkelt administration af Pembrolizumab i den neoadjuvante indstilling. (NeoSenti)

Melanom (hudkræft)

Belgien
iLeukon Therapeutics, Inc.

Ikke rekrutterer endnu

En fase II-undersøgelse af ILKN421H med pembrolizumab i avanceret ikke-småcellet lungekræft

Lokalt fremskreden eller metastatisk ikke-småcellet lungekræft (NSCLC)
Sinocelltech Ltd.

Rekruttering

Et studie til evaluering af sikkerheden og tolerabiliteten af SCTB14 som førstelinjeterapi ved ikke-småcellet lungekraeft.

Ikke-småcellet lungekarcinom (NSCLC)

Kina
UNC Lineberger Comprehensive Cancer Center
Exelixis

Ikke rekrutterer endnu

H&N NEO-COMBAT XL: Neoadjuvant XL-092 (Zanzalintinib) og Pembrolizumab (Keytruda) i kirurgisk resikabel, HPV-negativ mundhuleskivecelcancer (OCSCC) (NEO COMBAT XL)

Hoved- og halskræft | Mundhule pladecellekarcinom

Forenede Stater
Seda S. Tolu
Incyte Corporation

Rekruttering

Amping up With PemJAK

Non-Hodgkin lymfom | Perifert T-celle lymfom | Hodgkins sygdom tilbagevendende | Gråzone lymfom | Primært mediastinalt B-celle lymfom | Kutane T-celle lymfomer | Hodgkins sygdom lymfom | Non-Hodgkin lymfom refraktært/tilbagefaldende

Forenede Stater
M.D. Anderson Cancer Center

Ikke rekrutterer endnu

Blood and imagE-guided Optimization of Neoadjuvant Therapy in People With Early Stage Triple-negative Breast cancER - the BETTER Trial

Tredobbelt negativ brystkræft | Fase 2 | Blood and Image Guided | Optimization of Neoadjuvant Therapy

Forenede Stater
Merck Sharp & Dohme LLC

Rekruttering

En undersøgelse af Pembrolizumab hos japanske børnedeltagere med solide tumorer eller lymfomer og japanske voksne deltagere med Merkel-cellekarcinom (MK-3475-G21/KEYNOTE-G21)

Lymfom | Karcinom, Merkel Cell | Ondartet neoplasma

Japan
Chong Kun Dang Pharmaceutical

Rekruttering

Fase IA/IB-undersøgelse af CKD-512 alene og i kombination med pembrolizumab hos personer med avancerede eller metastatiske faste tumorer

Avancerede solide tumorer | Metastatiske faste tumorer

Sydkorea
Ismail Gögenur
Odense University Hospital; Zealand University Hospital; Aarhus University... og andre samarbejdspartnere

Ikke rekrutterer endnu

Neoadjuvant immunoterapi og organbevarende behandling hos patienter med stadium I-III dMMR tyktarmskræft (RESET C2)

Immunterapi | Pembrolizumab | DMMR tyktarmskræft | Tyktarmskræft fase I | Tyktarmskræft Stadium II/III

Danmark
Yonsei University

Ikke rekrutterer endnu

En fase IIb randomiseret klinisk undersøgelse af vedligeholdelsesterapi baseret på immunkontrolhæmmere til patienter med fremskreden galdevejskræft

Avanceret kræft | Galdevejsneoplasmer | Immunterapi

Sydkorea

Ramucirumab Plus Pembrolizumab vs standardkemoterapi til behandling af trin IV eller tilbagevendende ikke-småcellet lungekræft efter immunterapi, Pragmatica-lungeundersøgelse

Pragmatica-Lung: A Prospective Randomized Study of Ramucirumab (LY3009806; NSC 749128) Plus Pembrolizumab (MK-3475; NSC 776864) Versus Standard of Care for deltagere, der tidligere er behandlet med immunterapi for trin IV-cancercelle-stadie eller tilbagevendende celle

Studieoversigt

Status

Betingelser

Intervention / Behandling

Detaljeret beskrivelse

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Anslået)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Kliniske forsøg med Pembrolizumab

Søg i lignende forsøg

Sponsorer og samarbejdspartnere

Medicinske tilstande

Narkotikainterventioner

CROs by country

CROs in Iran

Betingelser

Sjældne sygdomme

Narkotikainterventioner

Kosttilskud

Sponsor / samarbejdspartnere

Placeringer