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En undersøgelse af Milvexian hos deltagere efter et nyligt akut koronarsyndrom (LIBREXIA-ACS)

2. juli 2026 opdateret af: Janssen Research & Development, LLC

En fase 3, randomiseret, dobbeltblind, placebokontrolleret, hændelsesdrevet undersøgelse for at demonstrere effektiviteten og sikkerheden af Milvexian, en oral faktor XIa-hæmmer, efter et nyligt akut koronarsyndrom

Formålet med denne undersøgelse er at evaluere, at milvexian er overlegen i forhold til placebo, ud over standardbehandling, med hensyn til at reducere risikoen for alvorlig kardiovaskulær hændelse (MACE) (sammensætningen af kardiovaskulær [CV] død, myokardieinfarkt [MI] ], og iskæmisk slagtilfælde).

Studieoversigt

Status

Afsluttet

Betingelser

Akut koronarsyndrom

Intervention / Behandling

Undersøgelsestype

Interventionel

Tilmelding (Faktiske)

14194

Fase

Fase 3

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiesteder

Argentina
- - Bahía Blanca, Argentina, B8001HXM
    - Hospital Italiano Regional Del Sur
  - Bahía Blanca, Argentina, 8000
    - Hospital Espanol De Bahia Blanca
  - Buenos Aires, Argentina, C1280AEB
    - Hospital Británico de Buenos Aires
  - Buenos Aires, Argentina, C1181ACH
    - Hospital Italiano de Buenos Aires
  - Buenos Aires, Argentina, C1187AAN
    - Sanatorio Finochietto
  - CABA, Argentina, C1180AAX
    - Sanatorio Güemes
  - Ciudad Autonoma Buenos Aires, Argentina, C1093AAS
    - Fundacion Favaloro
  - Ciudad Autonoma Buenos Aires, Argentina, C1430EGF
    - Clinica Adventista Belgrano
  - Ciudad Autonoma Buenos Aires, Argentina, 1425
    - Centro Medico Dra. Laura Maffei - Investigacion Clinica Aplicada
  - Ciudad Autonoma Buenos Aires, Argentina, 1428
    - Instituto Cardiovascular de Buenos Aires
  - Coronel Suárez, Argentina, B7540GHD
    - Clinica Coronel Suarez
  - Córdoba, Argentina, X5000JHQ
    - Sanatorio Allende
  - Córdoba, Argentina, X5016KEH
    - Hospital Privado Centro Medico de Cordoba
  - Córdoba, Argentina, 5000
    - Hospital San Roque
  - Córdoba, Argentina, 5000
    - Clínica Chutro
  - Córdoba, Argentina, X5002HWE
    - Instituto Privado De Especialidades Medicas S.A. Fundacion J Robert Cade
  - Córdoba, Argentina, X5004CDT
    - Hospital Cordoba
  - Córdoba, Argentina, X5006CBI
    - Centro Médico Luquez
  - Córdoba, Argentina, 5000
    - Sanatorio Duarte Quiroz
  - Córdoba, Argentina, X5000AAI
    - Clinica Romagosa
  - Córdoba, Argentina, X5000AAW
    - Clinica Privada del Prado
  - Córdoba, Argentina, X5000
    - Sanatorio de la Canada
  - La Plata, Argentina, B1900AXI
    - Hospital Italiano de La Plata
  - Mar del Plata, Argentina, B7600FYK
    - Centro de Investigaciones Medicas Mar del Plata
  - Quilmes, Argentina, B1878DKF
    - Sanatorio Modelo de Quilmes
  - Rosario, Argentina, S2000SDV
    - Sanatorio Parque
  - Rosario, Argentina, S2002KDS
    - Hospital Provincial del Centenario
  - Rosario, Argentina, S2000DSR
    - Instituto Cardiovascular de Rosario
  - Rosario, Argentina, S2001ODA
    - Hospital Italiano Garibaldi
  - Salta, Argentina, 4400
    - Centro de Investigaciones Clinicas Salta
  - Salta, Argentina, 4400
    - Centro Cardiovascular Salta
  - San Juan Bautista, Argentina, B1888AAE
    - Hospital El Cruce
  - San Martin, Argentina, 1650
    - Corporacion Medica de Gral. San Martin S.A.
  - San Miguel de Tucumán, Argentina, T4000ICL
    - Investigaciones Clinicas Tucuman
  - San Nicolás, Argentina, 2900
    - Estudios Clinicos de los Arroyos
  - Santa Fe, Argentina, S3000FUJ
    - Sanatorio Medico de Diagnostico Y Tratamiento
  - Santa Fe, Argentina, S3000AZH
    - Sanatorio Mayo SA
  - Santa Fe, Argentina, S3000EOZ
    - Hospital José María Cullen
  - Venado Tuerto, Argentina, S2600KUE
    - Sanatorio San Martin
  - Villa María, Argentina, X5900JKA
    - Clinica Privada Fusavim SRL
Australien
- - Adelaide, Australien, 5000
    - Royal Adelaide Hospital
  - Adelaide, Australien, 5042
    - Flinders Medical Centre
  - Ballarat, Australien, 3350
    - Ballarat Base Hospital
  - Birtinya, Australien, 4575
    - Sunshine Coast University Hospital
  - Cairns, Australien, 4870
    - Cairns Base Hospital
  - Camperdown, Australien, 2050
    - Royal Prince Alfred Hospital
  - Concord, Australien, 2139
    - Concord Repatriation General Hospital
  - Garran, Australien, 2605
    - The Canberra Hospital
  - Herston, Australien, 4029
    - Royal Brisbane and Women's Hospital
  - Hobart, Australien, 7000
    - Royal Hobart Hospital
  - Kingswood, Australien, 2747
    - Nepean Hospital
  - Milton, Australien, 4064
    - Core Research Group
  - Murdoch, Australien, 6150
    - Fiona Stanley Hospital
  - Southport, Australien, 4215
    - Gold Coast University Hospital
  - Sydney, Australien, 2145
    - Westmead Hospital
  - Traralgon, Australien, 3844
    - Latrobe Regional Hospital
  - Wollongong, Australien, 2500
    - Wollongong Hospital
  - Woodville South, Australien, 5011
    - The Queen Elizabeth Hospital
Belgien
- - Bonheiden, Belgien, 2820
    - Imeldaziekenhuis
  - Brasschaat, Belgien, 2930
    - AZ Klina
  - Bruges, Belgien, 8000
    - AZ Sint-Jan
  - Brussels, Belgien, 1200
    - Cliniques Universitaires Saint Luc
  - Brussels, Belgien, 1070
    - CUB Hopital Erasme
  - Brussels, Belgien, 1090
    - Universitair Ziekenhuis Brussel
  - Brussels, Belgien, 1020
    - C.H.U. Brugmann
  - Genk, Belgien, 3600
    - Ziekenhuis Oost-Limburg
  - Ghent, Belgien, 9000
    - AZ Sint-Lucas
  - Hasselt, Belgien, 3500
    - Jessa Ziekenhuis
  - Liège, Belgien, 4000
    - CHR de la Citadelle
  - Mechelen, Belgien, 97770
    - AZ Sint-Maarten
  - Mol, Belgien, 2400
    - Heilig Hart Ziekenhuis Lier
  - Mons, Belgien, 7000
    - CHU Ambroise Paré
  - Roeselare, Belgien, 8800
    - AZ Delta
  - Turnhout, Belgien, 2300
    - AZ Turnhout
Brasilien
- - Belo Horizonte, Brasilien, 30380-090
    - Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa
  - Belo Horizonte, Brasilien, 30150-240
    - Cardresearch - Cardiologia Assistencial
  - Belo Horizonte, Brasilien, 30140-062
    - Hospital Vera Cruz
  - Belo Horizonte, Brasilien, 30140-073
    - IMINC Instituto Mineiro de Intervencao Cardiologica LTDA
  - Botucatu, Brasilien, 18618-686
    - UNESP - Faculdade de Medicina da Universidade Estadual Paulista - Campus Botucatu
  - Brasília, Brasilien, 70390903
    - Hospital do Coração do Brasil
  - Brasília, Brasilien, 70710 149
    - Centro de Cardiologia Clinica e Pesquisa Doutora Juliana Souza Ltda CECAP Centro de Cardiologia Clinica
  - Campina Grande do Sul, Brasilien, 83430-000
    - Sociedade Hospitalar Angelina Caron
  - Campinas, Brasilien, 13060-080
    - Instituto de Pesquisa Clínica de Campinas
  - Campinas, Brasilien, 13010-001
    - C.E.C.-Centro Especializado em Cardiologia Ltda.- Loema Medicina e Bem Estar
  - Criciúma, Brasilien, 88811-508
    - Sociedade Literaria e Caritativa Santo Agostinho Hospital Sao Jose
  - Curitiba, Brasilien, 80010-030
    - Irmandade Santa Casa de Misericordia de Curitiba
  - Curitiba, Brasilien, 80320-320
    - Hospital Cardiológico Costantini
  - Curitiba, Brasilien, 80230-130
    - Associacao Paranaense de Cultura PUCPR
  - Goiânia, Brasilien, 74605-020
    - Hospital das Clinicas da Universidade Federal de Goias
  - Marília, Brasilien, 17515-000
    - Instituto do Coracao de Marilia
  - Natal, Brasilien, 59020-035
    - Instituto Atena de Pesquisa Clinica
  - Passo Fundo, Brasilien, 99010-120
    - Instituto Méderi de Pesquisa e Saúde
  - Pelotas, Brasilien, 96015-290
    - Santa Casa de Misericordia de Pelotas
  - Porto Alegre, Brasilien, 90035-903
    - Hospital das Clinicas de Porto Alegre
  - Porto Alegre, Brasilien, 90160-093
    - Hospital Ernesto Dornelles
  - Porto Alegre, Brasilien, 90035-001
    - Associacao Hospitalar Moinhos de Vento
  - Porto Alegre, Brasilien, 90620-001
    - Fundação Universitaria de Cardiologia
  - Porto Alegre, Brasilien, 91350 200
    - Hospital Nossa Senhora da Conceicao S A
  - Porto Alegre, Brasilien, 90610-000
    - Uniao Brasileira de Educacao e Assistencia Hospital Sao Lucas da PUCRS
  - Porto Alegre, Brasilien, 90110-270
    - IMV Pesquisa Cardiologica Sociedade Simples HMD COR l
  - Poços de Caldas, Brasilien, 37701-033
    - Hospital Maternidade e Pronto Socorro Santa Lucia
  - Recife, Brasilien, 50100-060
    - PROCAPE - Universidade de Pernambuco Pronto Socorro Cardiológico de Pernambuco prof Luiz Tavares
  - Recife, Brasilien, 52051-380
    - Secretaria de Saude Hospital Agamenon Magalhaes
  - Ribeirão Preto, Brasilien, 14098-900
    - Hospital Das Clinicas Da Faculdade De Medicina De RPUSP HCRP
  - Rio de Janeiro, Brasilien, 22061-080
    - Hospital São Lucas
  - Salvador, Brasilien, 41810-010
    - Fundacao Bahiana de Cardiologia
  - Salvador, Brasilien, 40170310
    - Instituto CardioPulmonar
  - Salvador, Brasilien, 41810011
    - Hospital Da Bahia
  - Salvador, Brasilien, 40050-410
    - Hospital Santa Izabel Santa Casa de Misericordia da Bahia
  - Santo André, Brasilien, 09080-110
    - Pesquisare Saúde
  - São Bernardo do Campo, Brasilien, 09715-090
    - CEMEC - Centro Multidisciplinar de Estudos Clínicos
  - São José, Brasilien, 88103-460
    - Instituto de Cardiologia de Santa Catarina
  - São José do Rio Preto, Brasilien, 15090-000
    - Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
  - São Paulo, Brasilien, 01221-020
    - Irmandade Da Santa Casa De Misericordia De Sao Paulo
  - São Paulo, Brasilien, 05403-000
    - Hospital Das Clinicas Da Faculdade De Medicina Da USP
  - São Paulo, Brasilien, 04012-909
    - Instituto Dante Pazzanese de Cardiologia
  - São Paulo, Brasilien, 01323-903
    - Hospital Alemao Oswaldo Cruz
  - São Paulo, Brasilien, 01323 900
    - Real e Benemerita Associacao Portuguesa de Beneficencia
  - São Paulo, Brasilien, 08270-120
    - Casa de Saude Santa Marcelina - Hospital Santa Marcelina
  - São Paulo, Brasilien, 01323 000
    - FGM Clinica Paulista de Doencas Cardiovasculares Ltda
  - São Paulo, Brasilien, 05652000
    - Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein
  - Tatuí, Brasilien, 18270-170
    - Instituto de Moléstias Cardiovasculares Tatuí
  - Uberaba, Brasilien, 38025-350
    - HC-UFTM - Hospital de Clínicas da Universidade Federal do Triângulo Mineiro
  - Vitória, Brasilien, 29702-020
    - Clinica Cardioped Ltda
  - Vitória, Brasilien, 29055-450
    - CEDOES
  - Votuporanga, Brasilien, 15500-003
    - Santa Casa de Misericórdia de Votuporanga
Bulgarien
- - Blagoevgrad, Bulgarien, 2700
    - MHAT Puls
  - Burgas, Bulgarien, 8000
    - MHAT Heart and Brain
  - Gabrovo, Bulgarien, 5300
    - Multiprofile Hospital for Active Treatment Dr. Tota Venkova
  - Haskovo, Bulgarien, 6300
    - Multiprofile Hospital for Active Treatment - Haskovo
  - Panagyurishte, Bulgarien, 4500
    - MHAT Uni Hospital
  - Pernik, Bulgarien, 2300
    - SHATC Sveti Georgi-Pernik OOD
  - Pleven, Bulgarien, 5800
    - UMHAT 'Dr. Georgi Stranski', EAD
  - Pleven, Bulgarien, 5800
    - Multiprofile Hospital for Active Treatment Heart and Brain, Pleven
  - Plovdiv, Bulgarien, 4002
    - UMHAT 'Sv. Georgi' EAD
  - Plovdiv, Bulgarien, 4004
    - MHAT Sv. Karidad EAD
  - Sofia, Bulgarien, 1309
    - National Heart Hospital
  - Sofia, Bulgarien, 1750
    - University Multiprofile Hospital for Active Treatment- UMHAT Sveta Anna AD
  - Sofia, Bulgarien, 1431
    - Diagnostic Consultation Centre 'Alexandrovska' EOOD
  - Sofia, Bulgarien, 1527
    - University Multiprofile Hospital for Active Treatment - Tsaritsa Yoanna - ISUL, EAD
  - Sofia, Bulgarien, 1606
    - UMHATEM N I Pirogov
  - Sofia, Bulgarien, 1202
    - 2th MHAT - Sofia
  - Sofia, Bulgarien, 1431
    - UMHAT Prof. Dr. Aleksandar Chirkov
  - Sofia, Bulgarien, 1797
    - UMHAT Sofia Med
  - Stara Zagora, Bulgarien, 6003
    - UMHAT Prof. Dr. St. Kirkovich AD
Canada
- Alberta
  - Calgary, Alberta, Canada, T2N4N2
    - Foothills Hospital
  - Edmonton, Alberta, Canada, T6G 2B7
    - University of Alberta
- British Columbia
  - Surrey, British Columbia, Canada, V2V 0C6
    - Surrey Memorial Hospital
  - Vancouver, British Columbia, Canada, V5Z 1M9
    - Vancouver General Hospital
- Manitoba
  - Winnipeg, Manitoba, Canada, R2H 2A6
    - Saint Boniface General Hospital
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3J 3R4
    - Dalhousie University
- Ontario
  - Cambridge, Ontario, Canada, N1R 7R1
    - Dr. Saul Vizel Cardiac Research Office
  - Hamilton, Ontario, Canada, L8L 2X2
    - Hamilton Health Sciences Corporation
  - London, Ontario, Canada, N6A 5A5
    - London Health Sciences Centre
  - Newmarket, Ontario, Canada, L3Y 2R2
    - Southlake Regional Health Centre
  - Oakville, Ontario, Canada, L6M 0L8
    - Halton Healthcare Services Corporation
  - Ottawa, Ontario, Canada, K1Y 4W7
    - University of Ottawa Heart Institute
  - Peterborough, Ontario, Canada, K9J 0B2
    - Kawartha Cardiology Clinical Trials
  - St. Catharines, Ontario, Canada, L2S 0A9
    - Niagara Health System
  - Toronto, Ontario, Canada, M4N 3M5
    - Toronto Sunnybrook Hospital
  - Windsor, Ontario, Canada, N8X 5A6
    - Office of Dr. Anthony Glanz
- Quebec
  - Lévis, Quebec, Canada, G6V 4Z5
    - Clinique de Cardiologie de Lévis
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal General Hospital
  - Montreal, Quebec, Canada, H2L 4M1
    - Centre de recherche du CHUM
  - Québec, Quebec, Canada, G1V 4G5
    - Institut Universitaire de cardiologie et de pneumologie de Quebec
  - Québec, Quebec, Canada, 00
    - Montreal Heart Institute
  - Québec, Quebec, Canada, G1J 1Z6
    - Centre de Recherche Clinique de Quebec
  - Saint-Jean-sur-Richelieu, Quebec, Canada, J3A1C3
    - CardioVasc HR
  - Terrebonne, Quebec, Canada, J6V 2H2
    - CSSS du Sud de Lanaudiere - Hopital Pierre-Le Gardeur d/b/a CISSS de Lanaudiere
  - Trois-Rivières, Quebec, Canada, G8Z 3R9
    - CIUSSS de la Mauricie-et-du-Centre-du-Quebec
- Saskatchewan
  - Saskatoon, Saskatchewan, Canada, S7N 0W8
    - Royal University Hospital
Chile
- - Puerto Varas, Chile, 5551070
    - Quantum Research
  - Santiago, Chile, 8330024
    - Centro de Investigacion Clinica Universidad Catolica de Chile CICUC
  - Temuco, Chile, 4781156
    - Centro de Investigacion Clinica del Sur
  - Temuco, Chile, 4813299
    - Centro de Estudios Cardiologicos y de Medicina Interna
  - Viña del Mar, Chile, 2520997
    - Centro de Estudios Clinicos V Region Ltda
Danmark
- - Aahus N, Danmark, 8200
    - Aarhus University Hospital
  - Copenhagen S, Danmark, 2300
    - Amager Hospital
  - Frederiksberg, Danmark, 2000
    - Bispebjerg og Frederiksberg Hospital
  - Herning, Danmark, 7400
    - Herning Regional Hospital
  - Holbæk, Danmark, 4300
    - Holbæk Sygehus
  - Hvidovre, Danmark, 2650
    - Hvidovre Hospital
  - Slagelse, Danmark, 4200
    - Slagelse Sygehus
  - Svendborg, Danmark, 5700
    - Odense University Hospital
  - Viborg, Danmark, 8800
    - Viborg Hospital
Det Forenede Kongerige
- - Basingstoke, Det Forenede Kongerige, RG24 9NA
    - Basingstoke and North Hampshire Hospital
  - Bath, Det Forenede Kongerige, BA1 3NG
    - Royal United Hospital
  - Birmingham, Det Forenede Kongerige, B9 5SS
    - Birmingham Heartlands Hospital
  - Birmingham, Det Forenede Kongerige, B15 2WB
    - Queen Elizabeth Hospital
  - Blackpool, Det Forenede Kongerige, FY3 8NR
    - Blackpool Victoria Hospital
  - Bournemouth, Det Forenede Kongerige, BH7 7DW
    - Royal Bournemouth Hospital
  - Bristol, Det Forenede Kongerige, BS1 3NU
    - University Hospital Bristol and Weston NHS trust
  - Dorchester, Det Forenede Kongerige, DT1 2JY
    - Dorset County Hospital
  - Dudley, Det Forenede Kongerige, DY1 2HQ
    - Russels Hall Hospital
  - East Kilbride, Det Forenede Kongerige, G75 8RG
    - Hairmyres Hospital
  - Edinburgh, Det Forenede Kongerige, EH16 4SA
    - Royal Infirmary of Edinburgh
  - Exeter, Det Forenede Kongerige, EX2 5DW
    - Royal Devon and Exeter Hospital(Wonford)
  - Hampstead, Det Forenede Kongerige, NW3 2QG
    - Royal Free Hospital
  - Harefield, Det Forenede Kongerige, UB9 6JH
    - Harefield Hospital
  - Isleworth, Det Forenede Kongerige, TW7 6AF
    - West Middlesex University Hospital
  - Kingston upon Thames, Det Forenede Kongerige, KT2 7QB
    - Kingston Hospital
  - Leeds, Det Forenede Kongerige, LS1 3EX
    - Leeds General Infirmary
  - Lincoln, Det Forenede Kongerige, LN2 5QY
    - Lincoln County Hospital
  - London, Det Forenede Kongerige, W12 0HS
    - Hammersmith Hospital
  - London, Det Forenede Kongerige, EC1A 7BE
    - Barts Hospital
  - Londonderry, Det Forenede Kongerige, BT47 6SB
    - Altnagelvin Hospital
  - Manchester, Det Forenede Kongerige, M8 6RL
    - North Manchester General Hospital
  - Middlesbrough, Det Forenede Kongerige, TS4 3BW
    - James Cook University Hospital
  - Newcastle upon Tyne, Det Forenede Kongerige, NE7 7DN
    - Freeman Hospital
  - Peterborough, Det Forenede Kongerige, PE3 9GZ
    - Peterborough City Hospital
  - Plymouth, Det Forenede Kongerige, PL6 8DH
    - Derriford Hospital
  - Portsmouth, Det Forenede Kongerige, PO6 3LY
    - Queen Alexandra Hospital
  - Redhill, Det Forenede Kongerige, RH1 5RH
    - East Surrey Hospital
  - Stevenage, Det Forenede Kongerige, SG1 4AB
    - Lister Hospital
  - Swansea, Det Forenede Kongerige, SA6 6NL
    - Morriston Hospital
  - Taunton, Det Forenede Kongerige, TA1 5DA
    - Musgrove Park Hospital
  - Torquay, Det Forenede Kongerige, TQ2 7AA
    - Torbay Hospital-Devon
  - West Bromwich, Det Forenede Kongerige, B71 4HJ
    - Sandwell and West Birmingham Hospitals NHS Trust-Sandwell Gene
  - Wigan, Det Forenede Kongerige, WN1 2NN
    - Royal Albert Edward Infirmary
  - Yeovil, Det Forenede Kongerige, BA214AT
    - Yeovil District Hospital
Filippinerne
- - Angeles, Filippinerne, 2009
    - The Heart Specialists Clinic and Diagnostic Center
  - Cavite, Filippinerne, 4118
    - Silang Specialists Medical Center
  - Cebu, Filippinerne, 6000
    - Cebu Doctors University Hospital
  - Davao City, Filippinerne, 8000
    - Southern Philippines Medical Center
  - Davao City, Filippinerne, 8000
    - Davao Doctors Hospital
  - Davao City, Filippinerne, 8000
    - Central Lab Diabetes Wellness, Heart and Kidneys, Inc
  - Iloilo City, Filippinerne, 5000
    - St.Paul's Hospital-Iloilo
  - Lipa City, Filippinerne, 4217
    - Mary Mediatrix Medical Center
  - Mandaluyong, Filippinerne, 1552
    - Health Cube Medical Clinics
  - Manila, Filippinerne, 1000
    - Manila Doctors Hospital
  - Manila, Filippinerne, 1000
    - Medical Center Manila
  - Manila, Filippinerne, 1003
    - Chinese General Hospital & Medical Center
  - Manila, Filippinerne, 1000
    - Philippine General Hospital 1
  - Marikina City, Filippinerne, 1800
    - Amang Rodriguez Memorial Medical Center
  - Pasig, Filippinerne, 1605
    - The Medical City
  - Quezon, Filippinerne, 1102
    - St. Luke's Medical Center 1
  - San Juan City, Filippinerne, 1502
    - Cardinal Santos Medical Center
  - Santa Rosa, Filippinerne, 4026
    - The Medical City South Luzon
Forenede Stater
- Alabama
  - Alexander City, Alabama, Forenede Stater, 35010
    - Advanced Cardiovascular, LLC
  - Birmingham, Alabama, Forenede Stater, 35205
    - Ascension St. Vincent's Health System
  - Birmingham, Alabama, Forenede Stater, 35203
    - SORRA Research
  - Mobile, Alabama, Forenede Stater, 36604
    - IMC-Diagnostic and Medical Clinic
  - Mobile, Alabama, Forenede Stater, 36608
    - Cardiology Associates of Mobile Inc
- Arizona
  - Gilbert, Arizona, Forenede Stater, 85297
    - Mercy Gilbert Medical Center
  - Phoenix, Arizona, Forenede Stater, 85008
    - Valleywise Health Medical Center
  - Scottsdale, Arizona, Forenede Stater, 85258
    - HonorHealth Neurology
- Arkansas
  - Little Rock, Arkansas, Forenede Stater, 72211
    - Arkansas Heart Hospital
- California
  - Bakersfield, California, Forenede Stater, 93306
    - Bakersfield Memorial Hospital
  - Fremont, California, Forenede Stater, 94538
    - Mission Cardiovascular Research Institute
  - Newport Beach, California, Forenede Stater, 92663
    - Radin Cardiovascular Medical Group
  - Northridge, California, Forenede Stater, 91325
    - Valley Clinical Trials, Inc.
  - Palo Alto, California, Forenede Stater, 94304
    - VA Palo Alto Healthcare System
  - Palo Alto, California, Forenede Stater, 94304
    - Stanford University School of Medicine
  - Pasadena, California, Forenede Stater, 91105
    - Huntington Hospital
  - Redding, California, Forenede Stater, 96001
    - The Cardiovascular Center
  - San Diego, California, Forenede Stater, 92123
    - San Diego Cardiac Center
  - San Diego, California, Forenede Stater, 92103
    - University of California San Diego
  - San Diego, California, Forenede Stater, 92161
    - VA San Diego Health Care System
  - Santa Monica, California, Forenede Stater, 90401
    - UCLA
  - Santa Rosa, California, Forenede Stater, 95405
    - NorthBay Clinical Research, LLC
  - Stockton, California, Forenede Stater, 95204
    - Ramin Manshadi, MD
- Colorado
  - Littleton, Colorado, Forenede Stater, 80120
    - South Denver Cardiology Associates PC
- Connecticut
  - Danbury, Connecticut, Forenede Stater, 06810
    - Nuvance Health Medical Practices Cardiology Danbury
  - Stamford, Connecticut, Forenede Stater, 06905
    - Cardiology Associates of Fairfield County, P.C.
- District of Columbia
  - Washington D.C., District of Columbia, Forenede Stater, 20037
    - George Washington University Medical Center
- Florida
  - Boca Raton, Florida, Forenede Stater, 33434
    - FWD Clinical Research
  - Clearwater, Florida, Forenede Stater, 33756
    - Clearwater Cardiovascular Consultants
  - Fort Lauderdale, Florida, Forenede Stater, 33308
    - Holy Cross Hospital Inc.
  - Fort Lauderdale, Florida, Forenede Stater, 33312
    - Integrative Research Associates
  - Gainesville, Florida, Forenede Stater, 32610-0236
    - University of Florida Health Jacksonville
  - Hialeah, Florida, Forenede Stater, 33014
    - Inpatient Research Clinic LLC
  - Jacksonville, Florida, Forenede Stater, 32209
    - Shands Jacksonville Medical Center Inc dba UF Health Jacksonville
  - Loxahatchee Groves, Florida, Forenede Stater, 33470
    - Cardiology Partners Clinical Research Institute
  - Miami, Florida, Forenede Stater, 33173
    - Baptist Hospital of Miami
  - Naples, Florida, Forenede Stater, 34102
    - Advanced Research for Health Improvement
  - North Miami Beach, Florida, Forenede Stater, 33169
    - Amavita Clinical Research (Dr. Pedro Martinez-Clark)
  - Pembroke Pines, Florida, Forenede Stater, 33028
    - South Florida Research Solutions LLC
  - Safety Harbor, Florida, Forenede Stater, 34695
    - Coastal Cardiology Consultants
  - Sarasota, Florida, Forenede Stater, 34239-3513
    - Cardiovascular Center of Sarasota
  - Tampa, Florida, Forenede Stater, 33614
    - Tampa Cardiovascular Interventions and Research
  - Trinity, Florida, Forenede Stater, 34655
    - Interventional Cardiac Consultants
  - Wellington, Florida, Forenede Stater, 33449
    - Cardiology Partners Clinical Research Institute 1
- Georgia
  - Atlanta, Georgia, Forenede Stater, 30303
    - Grady Memorial Hospital
  - Cartersville, Georgia, Forenede Stater, 30121
    - Atlanta Clinical Research Center
  - Gainesville, Georgia, Forenede Stater, 30501
    - Northeast Georgia Heart Center
  - Thomasville, Georgia, Forenede Stater, 31792
    - Cardiovascular Consultants of South Georgia LLC
- Idaho
  - Coeur d'Alene, Idaho, Forenede Stater, 83814
    - Kootenai Medical Center
- Illinois
  - Chicago, Illinois, Forenede Stater, 60616
    - Insight Hospital and Medical Center Chicago
  - Chicago, Illinois, Forenede Stater, 60657
    - Illinois Heart and Vascular Foundation
  - Downers Grove, Illinois, Forenede Stater, 60515
    - Advocate Heart Institute
  - Gurnee, Illinois, Forenede Stater, 60031
    - Clinical Investigation Specialists, Inc.
  - Palos Hills, Illinois, Forenede Stater, 60465
    - Essential Concepts Research Solutions
  - Peoria, Illinois, Forenede Stater, 61636
    - Methodist Medical Center of Illinois
  - Peoria, Illinois, Forenede Stater, 61614
    - OSF HealthCare Cardiovascular Institute
  - Springfield, Illinois, Forenede Stater, 62701
    - Prairie Cardiovascular Consultants, Ltd.
  - Urbana, Illinois, Forenede Stater, 61801
    - Carle Foundation Hospital
- Indiana
  - Elkhart, Indiana, Forenede Stater, 46514-2487
    - Midwest Cardiovascular Research Foundation
  - Fort Wayne, Indiana, Forenede Stater, 46804
    - Northern Indiana Research Alliance
  - Muncie, Indiana, Forenede Stater, 47303
    - IU Health Ball Memorial Hospital
  - Richmond, Indiana, Forenede Stater, 47374
    - Reid Health
- Kansas
  - Overland Park, Kansas, Forenede Stater, 66209
    - Health Midwest Ventures Group, Inc d b a HCA MidAmerica Division, LLC
- Kentucky
  - Louisville, Kentucky, Forenede Stater, 40202
    - University of Louisville
  - Louisville, Kentucky, Forenede Stater, 40205
    - Norton Cardiovascular Associates
- Louisiana
  - Alexandria, Louisiana, Forenede Stater, 71301
    - Cambridge Medical Trials
  - Houma, Louisiana, Forenede Stater, 70360
    - Cardiovascular Institute of the South
  - New Orleans, Louisiana, Forenede Stater, 70121
    - Ochsner Clinic And Hospital
  - Slidell, Louisiana, Forenede Stater, 70458
    - Louisiana Heart Center
  - West Monroe, Louisiana, Forenede Stater, 71291
    - Monroe Research LLC
- Maine
  - Bangor, Maine, Forenede Stater, 04401
    - Eastern Maine Medical Center Northeast Cardiology Associates
- Maryland
  - Baltimore, Maryland, Forenede Stater, 21231
    - Johns Hopkins University School Of Medicine
  - Bethesda, Maryland, Forenede Stater, 20814
    - Suburban Hospital
  - Lanham, Maryland, Forenede Stater, 20706
    - Captiol Cardiology Associates
  - Rockville, Maryland, Forenede Stater, 20850
    - Shady Grove Office
  - Salisbury, Maryland, Forenede Stater, 21801
    - Tidal Health Peninsula Regional Inc.
- Massachusetts
  - Haverhill, Massachusetts, Forenede Stater, 01830
    - Pentucket Medical Associates
- Michigan
  - Ann Arbor, Michigan, Forenede Stater, 48109
    - University of Michigan
  - Bloomfield Hills, Michigan, Forenede Stater, 48302
    - St. Joseph Mercy Oakland
  - Flint, Michigan, Forenede Stater, 48504
    - AAMRC
  - Jackson, Michigan, Forenede Stater, 39216
    - Jackson Heart Clinic
  - Lansing, Michigan, Forenede Stater, 48912-1811
    - Sparrow Clinical Research Institute
- Minnesota
  - Duluth, Minnesota, Forenede Stater, 55802-2207
    - St. Luke's Cardiology Associates
  - Saint Paul, Minnesota, Forenede Stater, 55102
    - HealthEast Medical Research Institute
- Missouri
  - Chesterfield, Missouri, Forenede Stater, 63017
    - Mercy Medical Research Institute
  - Columbia, Missouri, Forenede Stater, 65211
    - The Curators of the University of Missouri on behalf of University of Missouri Health Care
  - Kansas City, Missouri, Forenede Stater, 64116
    - North Kansas City Hospital
  - Kansas City, Missouri, Forenede Stater, 64118
    - Spectrum Clinical Research
  - Springfield, Missouri, Forenede Stater, 65807
    - Cox Health
  - St Louis, Missouri, Forenede Stater, 63110
    - Saint Louis University
- Nebraska
  - Lincoln, Nebraska, Forenede Stater, 68506
    - Bryan LGH Heart Institute
  - Omaha, Nebraska, Forenede Stater, 68114
    - Methodist Physicians Clinic Heart Consultants
- Nevada
  - Las Vegas, Nevada, Forenede Stater, 89102
    - University Medical Center of Southern Nevada
- New Jersey
  - Brick, New Jersey, Forenede Stater, 08724
    - Ash Research Clinic
  - Englewood, New Jersey, Forenede Stater, 07631
    - Englewood Health
  - Newark, New Jersey, Forenede Stater, 07112
    - Newark Beth Israel Medical Center
  - Pomona, New Jersey, Forenede Stater, 08240
    - AtlantiCare Regional Medical Center
  - Somerset, New Jersey, Forenede Stater, 08873
    - Cardio Metabolic Institute
- New York
  - Buffalo, New York, Forenede Stater, 14203-1154
    - Buffalo General Medical Center
  - Jamaica, New York, Forenede Stater, 11418
    - Jamaica Hospital Medical Center
  - New York, New York, Forenede Stater, 10032
    - Columbia University Medical Center
  - New York, New York, Forenede Stater, 10065
    - Weill Cornell Medicine
  - New York, New York, Forenede Stater, 10065
    - Weil Cornell University
  - Poughkeepsie, New York, Forenede Stater, 12601
    - Hudson Valley Cardiovascular Practice, PC
  - The Bronx, New York, Forenede Stater, 10469
    - Cardiac Care & Vascular Medicine, PLLC
  - Valhalla, New York, Forenede Stater, 10532
    - Westchester Medical Center
- North Carolina
  - Cary, North Carolina, Forenede Stater, 27518
    - Clinical Trials of America 1
  - Chapel Hill, North Carolina, Forenede Stater, 27599-5021
    - UNC School of Medicine
  - Greensboro, North Carolina, Forenede Stater, 27401
    - The Moses H. Cone Memorial Hospital
  - High Point, North Carolina, Forenede Stater, 27262
    - Atrium Health Wake Forest Baptist
  - Lenoir, North Carolina, Forenede Stater, 28645
    - Clinical Trials of America
  - Matthews, North Carolina, Forenede Stater, 28105
    - Novant Health
  - Raleigh, North Carolina, Forenede Stater, 27607
    - Rex Hospital
  - Sanford, North Carolina, Forenede Stater, 27330
    - Sanford Cardiology
- North Dakota
  - Minot, North Dakota, Forenede Stater, 58701
    - Trinity Medical Group
- Ohio
  - Akron, Ohio, Forenede Stater, 44304
    - Summa Health System
  - Cincinnati, Ohio, Forenede Stater, 45267
    - University of Cincinnati
  - Cleveland, Ohio, Forenede Stater, 44109
    - Metro Health Hospital
  - Columbus, Ohio, Forenede Stater, 43214
    - Ohio Health
  - Kettering, Ohio, Forenede Stater, 45429
    - Kettering Medical Center
  - Springfield, Ohio, Forenede Stater, 45504
    - The Heart House
- Oklahoma
  - Bartlesville, Oklahoma, Forenede Stater, 74006
    - Ascension Medical Group - St. John Clinic Infectious Disease
  - Oklahoma City, Oklahoma, Forenede Stater, 73135
    - South Oklahoma Heart Research
  - Tulsa, Oklahoma, Forenede Stater, 74104
    - St John Health System Inc
- Pennsylvania
  - Bethlehem, Pennsylvania, Forenede Stater, 18017
    - Advanced Cardiac Care
  - Chambersburg, Pennsylvania, Forenede Stater, 17201
    - Chambersburg Hospital
  - Erie, Pennsylvania, Forenede Stater, 16507
    - Hamot Medical Center
  - Harrisburg, Pennsylvania, Forenede Stater, 17110
    - UPMC Pinnacle Health
  - Langhorne, Pennsylvania, Forenede Stater, 19047
    - St. Mary Medical Center
  - Philadelphia, Pennsylvania, Forenede Stater, 19104
    - Penn Presbyterian Medical Center
  - Wynnewood, Pennsylvania, Forenede Stater, 19096
    - Lankenau Institute for Medical Research
- South Carolina
  - Anderson, South Carolina, Forenede Stater, 29621
    - AnMed Health
  - Greenville, South Carolina, Forenede Stater, 29607
    - St. Francis Physician Services, Inc, DBA Upstate Cardiology Research
  - Greenville, South Carolina, Forenede Stater, 29065
    - Prisma Health
  - Rock Hill, South Carolina, Forenede Stater, 29732
    - Carolina Cardiology Associates
- South Dakota
  - Rapid City, South Dakota, Forenede Stater, 57701
    - Monument Health Clinical Research
- Tennessee
  - Chattanooga, Tennessee, Forenede Stater, 37403
    - Erlanger Health System
  - Jackson, Tennessee, Forenede Stater, 38301
    - Apex Cardiology
  - Nashville, Tennessee, Forenede Stater, 37232
    - Vanderbilt University
  - Nashville, Tennessee, Forenede Stater, 37205
    - Ascension Saint Thomas West Hospital
  - Oak Ridge, Tennessee, Forenede Stater, 37830
    - Parkway Cardiology Associates PC
- Texas
  - Amarillo, Texas, Forenede Stater, 79109
    - PharmaTex Research
  - Amarillo, Texas, Forenede Stater, 79106
    - Amarillo Heart Clinical Research Institute
  - El Paso, Texas, Forenede Stater, 79902
    - Med Research, Inc.
  - El Paso, Texas, Forenede Stater, 79905
    - Texas Tech University Health Sciences Center-El Paso
  - Fort Worth, Texas, Forenede Stater, 76104
    - Baylor Scott and White Research Institute 1
  - Houston, Texas, Forenede Stater, 77002
    - East Texas Cardiology, PA
  - Houston, Texas, Forenede Stater, 77027
    - Physician Research Network
  - Humble, Texas, Forenede Stater, 77338
    - Vital Heart and Vein
  - Kingwood, Texas, Forenede Stater, 77339
    - Texas Cardiology Research Center
  - Kyle, Texas, Forenede Stater, 78640
    - Ascension Texas Cardiovascular
  - Sherman, Texas, Forenede Stater, 75090
    - CardioVoyage
  - Tomball, Texas, Forenede Stater, 77375
    - Northwest Heart Clinical Research, LLC.
- Virginia
  - Falls Church, Virginia, Forenede Stater, 22042
    - Virginia Heart
  - Newport News, Virginia, Forenede Stater, 23601
    - Riverside Regional Medical Center
  - Norfolk, Virginia, Forenede Stater, 23507
    - Sentara Cardiovascular Research Institute
  - Winchester, Virginia, Forenede Stater, 22601
    - Winchester Medical Center
- Washington
  - Everett, Washington, Forenede Stater, 98201
    - Providence Regional Medical Center Everett
  - Tacoma, Washington, Forenede Stater, 98405
    - MultiCare Health System
  - Tacoma, Washington, Forenede Stater, 98405
    - Cardiac Surgery Group
- Wisconsin
  - La Crosse, Wisconsin, Forenede Stater, 54601-4795
    - Mayo Clinic Health System
  - Marshfield, Wisconsin, Forenede Stater, 54449
    - Marshfield Clinic
Frankrig
- - Angers, Frankrig, 49033
    - Chu Angers - Hôpital Hôtel Dieu
  - Caen, Frankrig, 14050
    - CH Prive Saint-Martin
  - Chambray-lès-Tours, Frankrig, 37170
    - CHRU de Tours - Hôpital Trousseau
  - Corbeil-Essonnes, Frankrig, 91106
    - Centre Hospitalier Sud Francilien
  - Créteil, Frankrig, 94000
    - Hopital Henri Mondor
  - Dijon, Frankrig, 21033
    - CHU Dijon
  - La Tronche, Frankrig, 38700
    - CHU de Grenoble Hopital Albert Michallon
  - Le Coudray, Frankrig, 28630
    - CH de Chartres - Hôpital Louis Pasteur
  - Lille, Frankrig, 59037
    - CHRU de Lille Hopital Claude Huriez
  - Lyon, Frankrig, 69007
    - Centre Hospitalier Saint Joseph Et Saint Luc
  - Montauban, Frankrig, 82017
    - Clinique Du Pont De Chaume
  - Montpellier, Frankrig, 34295
    - CHU de Montpellier Hôpital Saint Eloi
  - Mulhouse, Frankrig, 68051
    - Centre Hospitalier Emile Muller
  - Nantes, Frankrig, 44093
    - CHU Nantes, Institut du thorax
  - Nice, Frankrig, 06002
    - Centre Hospitalier Universitaire - de Nice - Hopital Pasteur
  - Nîmes, Frankrig, 30029
    - Hopital Caremeau
  - Paris, Frankrig, 75018
    - Hopital Bichat - Claude Bernard
  - Paris, Frankrig, 75012
    - Hôpital Saint-Antoine
  - Paris, Frankrig, 75010
    - Hôpital Lariboisière
  - Paris, Frankrig, 75679
    - Hôpital Cochin
  - Pau, Frankrig, 64046
    - Centre Hospitalier de Pau
  - Pessac, Frankrig, 33604
    - Hôpital du Haut Lévêque
  - Poitiers, Frankrig, 86000
    - CHU Poitiers - Hôpital la Milétrie
  - Potigny, Frankrig, 14420
    - Hopital de Bicetre
  - Rouen, Frankrig, 78000
    - Clinique Saint-Hilaire - Centre Frédéric Joliot
  - Rouen, Frankrig, 76031
    - CHU Rouen Hopital Charles Nicolle
  - Strasbourg, Frankrig, 67200
    - Nouvel Hopital Civil - CHU Strasbourg
  - Toulouse, Frankrig, 31059
    - Hopital Rangueil
  - Vandœuvre-lès-Nancy, Frankrig, 54500
    - CHU de Nancy - Hopital de Brabois
  - Versailles, Frankrig, 78157
    - Hôpital André Mignot
Grækenland
- - Alexandroupoli, Grækenland, 68100
    - Uni General Hospital of Alexandroupolis
  - Athens, Grækenland, 15125
    - Athens Medical Center
  - Athens, Grækenland, 115 26
    - Henry Dunant hospital
  - Athens, Grækenland, 11527
    - Hippokration Hospital
  - Athens, Grækenland, 12462
    - General Hospital of Athens Attikon
  - Athens, Grækenland, 16673
    - General Per Hospital of Athens Asklipiio Voulas
  - Athens, Grækenland, 115 27
    - General Hospital of Athens G Gennimatas
  - Athens, Grækenland, 14561
    - General Hospital of Attiki 'KAT'
  - Heraklion, Grækenland, 71110
    - University Hospital of Heraklion
  - Ioannina, Grækenland, 45500
    - University General Hospital Of Ioannina
  - Larissa, Grækenland, 41110
    - University Hospital of Larissa
  - Pátrai, Grækenland, 26500
    - General University Hospital of Patras
  - Thessaloniki, Grækenland, 56429
    - Papageorgiou General Hospital
  - Thessaloniki, Grækenland, 54636
    - AHEPA University General Hospital of Thessaloniki
  - Thessaloniki, Grækenland, 57010
    - Papanikolaou General Hospital of Thessaloniki
  - Thessaloniki, Grækenland, 54642
    - Hippokration Hospital 1
Holland
- - 's-Hertogenbosch, Holland, 5223 GZ
    - Jeroen Bosch Ziekenhuis
  - Alkmaar, Holland, 1815 JD
    - Noordwest Ziekenhuisgroep
  - Almelo, Holland, 7609PP
    - Ziekenhuisgroep Twente
  - Amersfoort, Holland, 3813 TZ
    - Meander Medisch Centrum
  - Amsterdam, Holland, 1091 AC
    - Onze Lieve Vrouwe Gasthuis
  - Deventer, Holland, 7416 SE
    - Deventer Ziekenhuis
  - Ede, Holland, 6716 RP
    - Ziekenhuis Gelderse Vallei
  - Eindhoven, Holland, 5623 EJ
    - Catharina Ziekenhuis
  - Emmen, Holland, 7824 AA
    - TREANT zorggroep
  - Enschede, Holland, 7512 KZ
    - Medisch Spectrum Twente
  - Goes, Holland, 4462 RA
    - Admiraal De Ruyter Ziekenhuis - Goes
  - Gouda, Holland, 2803 HH
    - Groene Hart Ziekenhuis
  - Harderwijk, Holland, 3844 DG
    - Ziekenhuis St Jansdal
  - Heerlen, Holland, 6419 PC
    - Zuyderland Medical Center
  - Helmond, Holland, 5707 HA
    - Elkerliek Ziekenhuis
  - Leiderdorp, Holland, 2353 GA
    - Alrijne Ziekenhuis Leiden ; Cardiology
  - Maastricht, Holland, 6229 HX
    - Maastricht UMC
  - Nieuwegein, Holland, 3435 CM
    - St. Antonius Ziekenhuis Nieuwegein
  - Nijmegen, Holland, 6525GA
    - Radboudumc
  - Roosendaal, Holland, 4708 AE
    - Bravis
  - Rotterdam, Holland, 3045 PM
    - Sint Franciscus Gasthuis
  - Sneek, Holland, 8601 ZR
    - D & A Research
  - Tiel, Holland, 4002 WA
    - Ziekenhuis Rivierenland
  - Utrecht, Holland, 3582 KE
    - Diakonessenhuis
  - Veldhoven, Holland, 5504 DB
    - Maxima Medisch Centrum
  - Venlo, Holland, 5912 BL
    - VieCuri Medisch Centrum
  - Zutphen, Holland, 7207
    - Gelre Ziekenhuizen Zutphen
Indien
- - Ahmedabad, Indien, 380006
    - NHL Medical College (SVP Hospital IMSR)
  - Aligarh, Indien, 202001
    - Jawaharlal Nehru Medical College and Hospital
  - Bangalore, Indien, 560069
    - Sri Jayadeva Institute
  - Belagavi, Indien, 590010
    - KLE's Dr. Prabhakar Kore Hospital & Medical Research Centre (MRC)
  - Bikaner, Indien, 334003
    - S.P.Medical College & AG of Hospitals
  - Chennai, Indien, 600002
    - Tamil Nadu Government Multi Super Speciality Hospital
  - Chennai, Indien, 600006
    - Apollo Hospitals 1
  - Delhi, Indien, 110062
    - Batra Hospital and Medical Research Centre
  - Hyderabad, Indien, 500012
    - Osmania General Hospital
  - Hyderbad, Indien, 500034
    - Care Hospitals
  - Kochi, Indien, 682018
    - Lisie Hospital
  - Kolkata, Indien, 700020
    - IPGMER and SSKM Hospital
  - Kolkata, Indien, 700099
    - Rabindranath Tagore International Institute of Cardiac Sciences
  - Kolkata, Indien, 700014
    - NRS Medical college
  - Ludhiana, Indien, 141001
    - Dayanand Medical College & Hospital, Tagore Nagar, Civil Lines
  - Mangalore, Indien, 575001
    - Kasturba Medical College Hospital
  - Mumbai, Indien, 400012
    - Seth G S Medical College and KEM Hospital
  - Nagpur, Indien, 440010
    - Arneja Heart Institute
  - Nagpur, Indien, 440012
    - Crescent Hospital & Heart Center
  - Nagpur, Indien, 440015
    - Central India Cardiology Hospital and Research Institute
  - New Delhi, Indien, 110029
    - All India Institute of Medical Sciences
  - New Delhi, Indien, 110060
    - Sir Ganga Ram Hospital
  - Patna, Indien, 800014
    - Indira Gandhi Institute of Medical Sciences
  - Pune, Indien, 411001
    - Ruby Hall Clinic
  - Pune, Indien, 411011
    - KEM Hospital & Research Centre
  - Shimoga, Indien, 577205
    - Nanjappa Hospital
  - Surat, Indien, 395002
    - Unicare Heart Institute
  - Vijayawada, Indien, 520008
    - Government Siddhartha Medical College
  - Visakhapatnam, Indien, 530002
    - King George Hospital
Israel
- - Afula, Israel, 18101
    - Haemek Medical Center
  - Ashdod, Israel, 7747629
    - Samson Assuta Ashdod University Hospital
  - Ashkelon, Israel, 78278
    - Barzilai Medical Center
  - Beersheba, Israel, 84101
    - Soroka University Medical Center
  - Haifa, Israel, 31096
    - Rambam Health Care Campus
  - Haifa, Israel, 31048
    - Bnai Zion Medical Center
  - Haifa, Israel, 3436212
    - Carmel Medical Center
  - Holon, Israel, 58100
    - Wolfson Medical Center
  - Jerusalem, Israel, 9103102
    - Shaare Zedek Medical Center
  - Jerusalem, Israel, 9124001
    - Hadassah Medical Center
  - Jerusalem, Israel, 9112001
    - Hadassah University Hospita Ein Kerem
  - Kfar Saba, Israel, 4428164
    - Meir Medical Center
  - Naharya, Israel, 2633737
    - Health Corporation of Galilee Medical Center
  - Petah Tikva, Israel, 49100
    - Rabin Medical Center
  - Ramat Gan, Israel, 5262001
    - Chaim Sheba Medical Center
  - Rehovot, Israel, 7610001
    - Kaplan Medical Center
  - Rishon LeZiyyon, Israel, 70300
    - Assaf Harofeh Medical Center
  - Safed, Israel, 13100
    - Ziv Medical Center
  - Tiberias, Israel, 15208
    - Baruch Padeh Medical Center
Italien
- - Alessandria, Italien, 15121
    - Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo Alessandria
  - Bergamo, Italien, 24127
    - Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni XXIII)
  - Bergamo, Italien, 24125
    - Cliniche Humanitas Gavazzeni
  - Bologna, Italien, 40100
    - Azienda USL di Bologna - Ospedale Maggiore
  - Chieti, Italien, 66013
    - Universita D Annunzio
  - Ferrara, Italien, 44123
    - Azienda Ospedaliero-Universitaria di Ferrara Arcispedale Sant Anna
  - La Spezia, Italien, 19021
    - Ospedale Sant'Andrea
  - Mestre, Italien, 30035
    - Azienda Ulss 3 Serenissima distretto di Mirano
  - Milan, Italien, 20122
    - Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico
  - Milan, Italien, 20138
    - Centro Cardiologico Monzino
  - Milan, Italien, 20162
    - Azienda Socio Sanitaria Territoriale Niguarda (Grande Ospedale Metropolitano Niguarda)
  - Naples, Italien, 80131
    - Azienda Ospedaliera Universitaria Federico II
  - Parma, Italien, 43100
    - Azienda Ospedaliero Universitaria di Parma
  - Pavia, Italien, 27100
    - Fondazione IRCCS Policlinico San Matteo
  - Pisa, Italien, 56124
    - A. O.U. Pisana Ospedale di Cisanello
  - Roma, Italien, 00161
    - AOU Policlinico Umberto I
  - Roma, Italien, 00168
    - Fondazione Policlinico Universitario A Gemelli IRCCS
  - Rozzano, Italien, 20089
    - Istituto Clinico Humanitas
  - Sassari, Italien, 07100
    - Ospedale San Francesco
  - Seriate, Italien, 24068
    - Ospedale Bolognini
  - Sesto San Giovanni, Italien, 20099
    - IRCCS Multimedica di Sesto San Giovanni
  - Torrette Di Ancona, Italien, 60126
    - Azienda Ospedaliero Universitaria Ospedali Riuniti
  - Treviglio, Italien, 24047
    - Azienda Ospedaliera Ospedale Treviglio-Caravaggio di Treviglio
Japan
- - Aichi, Japan, 486-8510
    - Kasugai Municipal Hospital
  - Amagasaki Shi, Japan, 660 8550
    - Hyogo Prefectural Amagasaki General Medical Center
  - Chiba, Japan, 260 8677
    - Chiba University Hospital
  - Chiba, Japan, 273 8588
    - Funabashi Municipal Medical Center
  - Chikushino-shi, Japan, 818-8516
    - Saiseikai Futsukaichi Hospital
  - Fukui-shi, Japan, 910-8526
    - Fukui Prefectural Hospital
  - Fukuoka, Japan, 812-8582
    - Kyushu University Hospital
  - Fukuoka, Japan, 811-0213
    - Fukuoka Wajiro Hospital
  - Fukuoka, Japan, 810 8563
    - National Hospital Organization Kyushu Medical Center
  - Gifu, Japan, 500-8717
    - Gifu Prefectural General Medical Center
  - Gunma, Japan, 370-0829
    - National Hospital Organization Takasaki General Medical Center
  - Himeji-shi, Japan, 670-8560
    - Hyogo Prefectural Harima-Himeji General Medical Center
  - Hiratsuka-shi, Japan, 254-8502
    - Hiratsuka Kyosai Hospital
  - Hirosaki, Japan, 036-8203
    - Hirosaki University Hospital
  - Hiroshima, Japan, 730-8518
    - Hiroshima City Hiroshima Citizens Hospital
  - Isehara, Japan, 259-1193
    - Tokai University Hospital
  - Ishikawa, Japan, 924-0865
    - Public Central Hospital of Matto Ishikawa
  - Itabashi Ku, Japan, 173 8606
    - Teikyo University Hospital
  - Izunokuni-shi, Japan, 410-2295
    - Juntendo University Shizuoka Hospital
  - Kamogawa, Japan, 2960041
    - Tesshokai Kameda Clinic
  - Kanagawa, Japan, 227-8501
    - Showa University Fujigaoka Hospital
  - Kanazawa, Japan, 920-0007
    - Asanokawa, Kanazawa Cardiovascular Hospital
  - Kasuga-shi, Japan, 816-0864
    - Fukuoka Tokushukai Hospital
  - Kisarazu-shi, Japan, 292-8535
    - Kimitsu Chuo Hospital
  - Kitakyushu-shi, Japan, 802-8555
    - Kokura Memorial Hospital
  - Kochi, Japan, 780-8522
    - Chikamori Hospital
  - Koga, Japan, 811-3195
    - National Hospital Organization Fukuoka Higashi Medical Center
  - Kumamoto, Japan, 861-4193
    - Saiseikai Kumamoto Hospital
  - Kumamoto, Japan, 860-8556
    - Kumamoto University Hospital
  - Kurashiki, Japan, 710-8602
    - Kurashiki Central Hospital
  - Kure-shi, Japan, 736-0023
    - National Hospital Organization Kure Medical Center and Chugoku Cancer Center
  - Kyoto, Japan, 606-8507
    - Kyoto University Hospital
  - Kyoto, Japan, 612-8555
    - National Hospital Organization Kyoto Medical Center
  - Matsudo-shi, Japan, 270-2251
    - Tokushukai Chiba-Nishi General Hospital
  - Matsumoto-shi, Japan, 390-8510
    - Jisenkai Aizawa Hospital
  - Meguro-ku, Japan, 153-8515
    - Toho University Medical Center, Ohashi Hospital
  - Minatoku, Japan, 108-0073
    - Tokyo Saiseikai Central Hospital
  - Miyazaki, Japan, 880-2102
    - Miyazaki Medical Association Hospital
  - Nagoya, Japan, 460-0001
    - NHO Nagoya Medical Center
  - Nagoya, Japan, 466-8650
    - Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital
  - Nishinomiya Shi, Japan, 663 8501
    - Hyogo Medical University Hospital
  - Okayama, Japan, 702-8055
    - Okayama Rosai Hospital
  - Osaka, Japan, 540-0006
    - National Hospital Organization Osaka National Hospital
  - Osaka, Japan, 534-0021
    - Osaka City General Hospital
  - Osaka, Japan, 543-0035
    - Osaka Police Hospital
  - Saga, Japan, 849-8501
    - Saga University Hospital
  - Sagamihara, Japan, 252-0375
    - Kitasato University Hospital
  - Saitama, Japan, 351-0102
    - National Hospital Organization Saitama National Hospital
  - Saitama-shi, Japan, 339-0033
    - Iwatsuki Minami Hospital
  - Sendai, Japan, 980 8574
    - Tohoku University Hospital
  - Shinagawa City, Japan, 142 8666
    - Showa University Hospital
  - Shinjuku-ku, Japan, 162-8666
    - Tokyo Women's Medical University Hospital
  - Shiwa-gun, Japan, 028-3695
    - Iwate Medical University Hospital
  - Suita-Shi, Japan, 564-8565
    - National Cerebral and Cardiovascular Center
  - Takamatsu, Japan, 760-8557
    - Kagawa Prefectural Central Hospital
  - Tokushima, Japan, 770-8503
    - Tokushima University Hospital
  - Tokyo, Japan, 152-8902
    - National Hospital Organization Tokyo Medical Center
  - Tokyo, Japan, 101-8643
    - Mitsui Memorial Hospital
  - Tokyo, Japan, 104 8560
    - St. Luke's International Hospital
  - Tokyo, Japan, 113 8603
    - Nippon Medical School Hospital
  - Tokyo, Japan, 173 8610
    - Nihon University Itabashi Hospital
  - Tokyo, Japan, 198-0042
    - Ome Medical Center
  - Toyama, Japan, 930-8550
    - Toyama Prefectural Central Hospital
  - Tsu, Japan, 514-8507
    - Mie University Hospital
  - Tsuchiura, Japan, 300-0028
    - Tsuchiura Kyodo General Hospital
  - Tsukuba, Japan, 305 8558
    - Tsukuba Medical Center Hospital
  - Ube, Japan, 755-8505
    - Yamaguchi University Hospital
  - Urayasu-shi, Japan, 279-0001
    - Tokyo Bay Urayasu Ichikawa Medical Center
  - Ureshino-shi, Japan, 843-0393
    - National Hospital Organization Ureshino Medical Center
  - Wakayama, Japan, 641 8510
    - Wakayama Medical University Hospital
  - Yokohama, Japan, 232 0024
    - Yokohama City University Medical Center
Kina
- - Baotou, Kina, 014040
    - Baotou Central Hospital
  - Beijing, Kina, 100083
    - Peking University Third Hospital
  - Beijing, Kina, 100029
    - Beijing AnZhen Hospital, Capital Medical University
  - Beijing, Kina, 100034
    - Peking University First Hospital
  - Beijing, Kina, 100038
    - Beijing Shijitan Hospital
  - Beijing, Kina, 100039
    - Chinese PLA General Hospital
  - Beijing, Kina, 100050
    - Beijing Friendship Hospital Capital Medical University
  - Changchun, Kina, 130021
    - The First Hospital of Jilin University
  - Changzhou, Kina, 213000
    - Changzhou No 2 Peoples Hospital
  - Chengdu, Kina, 610041
    - West China Hospital Sichuan University
  - Chengdu, Kina, 610072
    - Sichuan Provincial Peoples Hospital
  - Chongqing, Kina, 400016
    - The First Affiliated Hospital of Chongqing Medical University
  - Dongguan, Kina, 523059
    - Dongguan People s Hospital
  - Fuzhou, Kina, 350005
    - The First Affiliated Hospital of Fujian Medical University
  - Guangzhou, Kina, 510080
    - Guangdong Provincial People's Hospital
  - Guangzhou, Kina, 510080
    - The First Affiliated Hospital of Sun Yat-sen University
  - Guiyang, Kina, 550000
    - The Affiliated Hospital of Guizhou Medical University
  - Guiyang, Kina, 550002
    - GuiZhou Privicial Peoples Hospital
  - Hangzhou, Kina, 310000
    - Zhejiang Provincial People's Hospital
  - Hangzhou, Kina, 310006
    - Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine
  - Hangzhou, Kina, 310016
    - Sir Run Run Shaw Hospital Zhejiang University School of Medicine
  - Hefei, Kina, 230001
    - Anhui province hospital
  - Huizhou, Kina, 516001
    - Huizhou Municipal Central Hospital
  - Jinan, Kina, 250012
    - Qilu Hospital of Shandong University
  - Jinan, Kina, 250033
    - The Second Affiliated Hospital, Shandong University
  - Jining, Kina, 272011
    - Shandong Jining No.1 People's Hospital
  - Lanzhou, Kina, 730030
    - Lanzhou University Second Hospital
  - Linfen, Kina, 041000
    - Linfen Central Hospital
  - Nanchang, Kina, 330006
    - The Second Affiliated Hospital of Nanchang University
  - Nanjing, Kina, 210029
    - Jiangsu Province Hospital
  - Nanjing, Kina, 210009
    - Zhongda Hospital Southeast University
  - Nanjing, Kina, 210000
    - Nanjing Drum Tower Hospital
  - Nanyang, Kina, 473000
    - The First Affiliated Hospital of Nanyang Medical College
  - Ningbo, Kina, 315010
    - Ningbo First Hospital
  - Shanghai, Kina, 200030
    - Shanghai Chest Hospital
  - Shanghai, Kina, 200032
    - Zhongshan Hospital Fudan University
  - Shanghai, Kina, 200011
    - Shanghai Ninth Peoples Hospital
  - Shantou, Kina, 515041
    - The First Affiliated Hospital of Shantou University Medical
  - Shenzhen, Kina, 518052
    - Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen
  - Suzhou, Kina, 215006
    - The First Affiliated Hospital of Soochow University
  - Suzhou, Kina, 210009
    - The Second Affiliatted Hospital of Soochow University
  - Taiyuan, Kina, 030013
    - Shanxi Cardiovascular Hospital
  - Tianjin, Kina, 300052
    - Tianjin Medical University General Hospital
  - Tianjin, Kina, 300211
    - The Second Hospital of Tianjin Medical University
  - Tianjin, Kina, 300121
    - Tianjin People's Hospital
  - Tianjin, Kina, 300222
    - Tianjin Chest Hospital
  - Wenzhou, Kina, 325000
    - The First Affiliated Hospital of Wenzhou Medical University
  - Wenzhou, Kina, 325000
    - Wenzhou Peoples Hospital
  - Wuhan, Kina, 430014
    - The Central Hospital of Wuhan
  - Wuhan, Kina, 430033
    - Hubei Zhongshan Hospital The Third Peoples Hospital of Hubei Province
  - Wuxi, Kina, 214023
    - Wuxi People s Hospital
  - Xi'an, Kina, 710061
    - The First Affiliated Hospital of Xian Jiaotong University
  - Xinxiang, Kina, 453003
    - The Third Affiliated Hospital of Xinxiang Medical University
  - Xuzhou, Kina
    - The Affiliated Hospital of Xuzhou Medical College
  - Yanji, Kina, 133000
    - Yanbian University Hospital
  - Yichang, Kina, 443003
    - Yichang Central Pepole's Hospital
  - Yinchuan, Kina, 750004
    - General Hospital of Ningxia Medical Hospital
  - Zhanjiang, Kina, 524001
    - Affiliated Hospital of Guangdong Medical University
  - Zhengzhou, Kina, 450052
    - The First Affiliated Hospital of Zhengzhou University
  - Zhongshan, Kina, 528403
    - Zhongshan City Peoples Hospital
  - Zunyi, Kina, 563000
    - Affiliated Hospital of Zunyi Medical University
Kroatien
- - Dubrovnik, Kroatien, 20000
    - General Hospital Dubrovnik
  - Krapinske Toplice, Kroatien, 49217
    - Special Hospital for medical rehabilitation
  - Rijeka, Kroatien, 51000
    - Clinical Hospital Centre Rijeka
  - Slavonski Brod, Kroatien, 35000
    - General Hospital Slavonski Brod
  - Zagreb, Kroatien, 10000
    - University Hospital Dubrava
  - Zagreb, Kroatien, 10000
    - Poliklinika Solmed
Letland
- - Daugavpils, Letland, LV5417
    - Daugavpils Regional Hospital
  - Riga, Letland, LV1002
    - Pauls Stradins Clinical University Hospital
  - Riga, Letland, LV-1038
    - Riga East Clinical University Hospital
Litauen
- - Kaunas, Litauen, LT-50161
    - Hospital of Lithuanian University of Health Sciences Kaunas Clinics
  - Klaipėda, Litauen, LT-92288
    - Klaipeda Seamen's Hospital, Public Institution
  - Vilnius, Litauen, LT-08661
    - Vilnius University Hospital Santariskiu Clinic, Public Institution
Malaysia
- - Kota Bharu, Malaysia, 15200
    - Hospital University Sains Malaysia
  - Kota Bharu, Malaysia, 15586
    - Hospital Raja Perempuan Zainab II
  - Kota Kinabalu, Malaysia, 88500
    - Hospital Queen Elizabeth
  - Kuala Lumpur, Malaysia, 59100
    - University Malaya Medical Centre
  - Kuala Lumpur, Malaysia, 50400
    - Institut Jantung Negara
  - Kuala Lumpur, Malaysia, 56000
    - Pusat Perubatan Universiti Kebangsaan Malaysia
  - Kuching, Malaysia, 93200
    - Sarawak General Hospital
  - Miri, Malaysia, 98000
    - Hospital Miri
  - Pulau Pinang, Malaysia, 10990
    - Hospital Pulau Pinang
  - Seberang Jaya, Malaysia, 13700
    - Hospital Seberang Jaya
  - Selayang Baru Utara, Malaysia, 68000
    - Universiti Teknologi Mara
Mexico
- - Aguascalientes, Mexico, 20230
    - Hospital Cardiologica Aguascalientes
  - Culiacán, Mexico, 80230
    - Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
  - Mazatlán, Mexico, 82126
    - Centro de Estudios de de alta Especialidad de Sinaloa
  - Monterrey, Mexico, 64718
    - Private Practice Dr Amaya
  - México, Mexico, 14080
    - Instituto Nacional de Cardiologia Dr. Ignacio Chavez
  - Querétaro, Mexico, 76000
    - Centro de Estudios Clinicos de Queretaro S.C
  - San Luis Potosí City, Mexico, 78200
    - Centro de Atencion e Investigacion Cardiovascular del Potosi S C
  - Tijuana, Mexico, 22500
    - Centro de Investigacion Cardiovascular y Metabólica
  - Torreón, Mexico, 27000
    - Centro de Investigacion Dr. Alberto Esteban Bazzoni Ruiz
  - Xalapa, Mexico, 91193
    - Dr Enrique Lopez Rosas
New Zealand
- - Auckland, New Zealand, 1030
    - Auckland City Hospital
  - Auckland, New Zealand, 0740
    - North Shore Hospital
  - Christchurch, New Zealand, 4710
    - University of Otago
  - Dunedin, New Zealand, 9016
    - Dunedin Public Hospital
  - Hastings, New Zealand, 4120
    - Hawkes Bay Hospital
  - New Plymouth, New Zealand, 4342
    - Taranaki Base Hospital
  - Otahuhu, New Zealand, 2025
    - Middlemore Hospital
  - Rotorua, New Zealand, 3010
    - Rotorua Hospital
  - Tauranga, New Zealand, 3143
    - Tauranga Hospital
  - Whangarei, New Zealand, 110
    - Whangarei Hospital
Nordmakedonien
- - Skopje, Nordmakedonien, 1109
    - University Clinic of Cardiology
  - Tetovo, Nordmakedonien, 1200
    - Clinical Hospital Tetovo
Polen
- - Bialystok, Polen, 15 276
    - Uniwersytecki Szpital Kliniczny w Bialymstoku
  - Bydgoszcz, Polen, 85 231
    - NZOZ Centrum Medyczne KERmed
  - Bytom, Polen, 41 902
    - Samodzielny Publiczny Zaklad Opieki Zdrowotnej
  - Elblag, Polen, 82 300
    - Wojewodzki Szpital Zespolony w Elblagu
  - Katowice, Polen, 40-156
    - Clinical Medical Research Sp. z o.o.
  - Kielce, Polen, 25-525
    - Specjalistyczna Poradnia Kardiologiczna i Nadcisnienia Tetniczego
  - Krakow, Polen, 30-082
    - Ewa Mirek-Bryniarska Specjalistyczna Praktyka Lekarska
  - Krakow, Polen, 30-693
    - Krakowskie Centrum Kardiologii Inwazyjnej, Elektroterapii i Angiologii
  - Krakow, Polen, 31 202
    - Krakowski Szpital Specjalistyczny im Jana Pawla II
  - Lodz, Polen, 92-213
    - SPZOZ Centralny Szpital Kliniczny UM w Lodzi
  - Lublin, Polen, 20-954
    - Samodzielny Publiczny Szpital Kliniczny nr 4 w Lublinie
  - Lublin, Polen, 20 049
    - 1 Wojskowy Szpital Kliniczny z Polikliniką SPZOZ w Lublinie
  - Nałęczów, Polen, 24-140
    - NZOZ Osrodek Kardiologii Inwazyjnej -Ikardia
  - Olsztyn, Polen, 10-010
    - Futuremeds Olsztyn
  - Olsztyn, Polen, 10 561
    - Wojewodzki Szpital Specjalistyczny w Olsztynie
  - Oświęcim, Polen, 32-600
    - Medicome Sp. z o.o.
  - Poznan, Polen, 61 848
    - Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu
  - Przemyśl, Polen, 37-700
    - Wojewodzki Szpital im Sw Ojca Pio w Przemyslu
  - Siedlce, Polen, 08-110
    - Samodzielny Publiczny Szpital Wojewodzki im. Papieza Jana Pawla II
  - Skierniewice, Polen, 96-100
    - ETG Skierniewice
  - Sopot, Polen, 81 717
    - NZOZ PRO CORDIS Sopockie Centrum Badan Kardiologicznych
  - Torun, Polen, 87 100
    - Wojewodzki Szpital Zespolony Im L Rydygiera W Toruniu
  - Warsaw, Polen, 04-628
    - Narodowy Instytut Kardiologii Stefana Kardynala Wyszynskiego Panstwowy Instytut Badawczy
  - Wałbrzych, Polen, 58 309
    - Specjalistyczny Szpital im dra Alfreda Sokolowskiego w Walbrzychu
  - Wroclaw, Polen, 51 124
    - Wojewodzki Szpital Specjalistyczny We Wroclawiu
  - Wroclaw, Polen, 50 368
    - Uniwersytecki Szpital Kliniczny Im Jana Mikulicza Radeckiego We Wroclawiu
  - Wroclaw, Polen, 50 981
    - 4 Wojskowy Szpital Kliniczny Z Poliklinika SP ZOZ
Portugal
- - Aveiro, Portugal, 3814-501
    - Centro Hospitalar do Baixo Vouga E P E Unidade de Aveiro
  - Braga, Portugal, 4710-243
    - Hospital de Braga
  - Coimbra, Portugal, 3000-075
    - Uls Coimbra - Hosp. Univ. Coimbra
  - Covilha, Portugal, 6200-074
    - Centro Hospitalar Cova da Beira, EPE - Hospital Pêro da Covilhã
  - Guimarães, Portugal, 4835 044
    - Uls Alto Ave - Hosp. Sra. Da Oliveira Guimaraes
  - Leiria, Portugal, 2410-197
    - Centro Hospitalar de Leiria
  - Lisbon, Portugal, 1169-024
    - Centro Hospitalar de Lisboa Central
  - Lisbon, Portugal, 1649-035
    - Centro Hospitalar de Lisboa Norte Hospital Santa Maria
  - Santa Maria da Feira, Portugal, 4520-211
    - Centro Hospitalar de Entre o Douro e Vouga, E.P.E
  - Vila Nova de Gaia, Portugal, 4434-502
    - Centro Hospitalar de Vila Nova de Gaia Espinho E P E
  - Vila Real, Portugal, 5000-508
    - Centro Hospitalar de Trás os Montes e Alto Douro- Vila Real
Rumænien
- - Baia Mare, Rumænien, 430031
    - Spitalul Judetean de Urgenta Dr. Constantin Opris
  - Brasov, Rumænien, 500326
    - Spitalul Clinic Judetean de Urgenta Brasov
  - Bucharest, Rumænien, 014461
    - Spitalul Clinic de Urgenta Bucuresti
  - Bucharest, Rumænien, 010825
    - Spitalul Universitar de Urgenta Militar Central 'Dr. Carol Davila'
  - Bucharest, Rumænien, 011461
    - Spitalul Universitar de Urgenta Elias, Clinica de Cardiologie
  - Bucharest, Rumænien, 022328
    - Institutul de urgenta pentru Boli Cardiovasculare Prof. Dr. C.C. Iliescu
  - Cluj-Napoca, Rumænien, 400006
    - Spitalul Clinic Judetean de Urgenta Cluj Napoca
  - Cluj-Napoca, Rumænien, 400000
    - Spitalul Angiocare SRL
  - Constanța, Rumænien, 900591
    - Spitalul Clinic Judetean de Urgenta Sf. Apostol Andrei
  - Craiova, Rumænien, 200147
    - Spitalul Clinic Judetean de Urgenta Craiova
  - Iași, Rumænien, 700503
    - Institutul de Boli Cardiovasculare Iasi
  - Oradea, Rumænien, 410167
    - Spitalul Clinic Judetean de Urgenta Oradea
  - Piteşti, Rumænien, 110424
    - SAL MED Pitesti
  - Tg. Mures, Rumænien, 540136
    - Spitalul Clinic Judetean de Urgenta Targu Mures
  - Timișoara, Rumænien, 300310
    - Institutul de Boli Cardiovasculare Timisoara
  - Timișoara, Rumænien, 300043
    - Clinica Medicaliss
  - Timișoara, Rumænien, 300079
    - Spitalul Clinic Municipal de Urgenta Timisoara
  - Târgu Mureş, Rumænien, 540136
    - Spitalul Clinic Judetean de Urgenta Targu Mures 1
Schweiz
- - Basel, Schweiz, 4031
    - Universitätsspital Basel
  - Bern, Schweiz, 3010
    - Universitätspital Bern, Universitätsklinik für Frauenheilkunde
  - Geneva, Schweiz, 1211
    - Hôpitaux Universitaires de Genève - HUG
  - Lugano, Schweiz, 6900
    - Istituto Cardiocentro Ticino
  - Zurich, Schweiz, 8091
    - Universitaetsspital Zuerich
Serbien
- - Belgrade, Serbien, 11080
    - Clinical Hospital Center Zemun
  - Belgrade, Serbien, 11000
    - University Clinical Center of Serbia
  - Belgrade, Serbien, 11080
    - University Clinical Hospital Center Dr Dragisa Misovic- Dedi
  - Belgrade, Serbien, 11000
    - Institute for Cardiovascular diseases Dedinje
  - Belgrade, Serbien, 11000
    - Clinical Center Dr Dragisa Misovic Dedinje
  - Belgrade, Serbien, 11000
    - Institute for Cardiovascular diseases Dedinje 1
  - Belgrade, Serbien, 11000
    - University Clinical Center of Serbia 1
  - Belgrade, Serbien, 11000
    - University Clinical Center of Serbia 2
  - Kamenitz, Serbien, 21204
    - Institute of Cardiovascular Diseases of Vojvodina
  - Kamenitz, Serbien, 21204
    - Institute of Cardiovascular Diseases of Vojvodina 1
  - Kragujevac, Serbien, 34000
    - University Clinical Center Kragujevac
  - Niš, Serbien, 18000
    - Clinical Center Niš
  - Niš, Serbien, 18000
    - Clinical Center Nis 1
  - Niška Banja, Serbien, 18205
    - Institute for Treatment and Rehabilitation Niska Banja
  - Pančevo, Serbien, 26000
    - General Hospital Pancevo
  - Smederevo, Serbien, 11300
    - General Hospital Smederevo
  - Sremska Mitrovica, Serbien, 22000
    - General Hospital Sremska Mitrovica
  - Užice, Serbien, 31000
    - General Hospital Uzice
  - Zaječar, Serbien, 19000
    - Health Center Zajecar
Singapore
- - Singapore, Singapore, 119074
    - National University Hospital
  - Singapore, Singapore, 529889
    - Changi General Hospital
  - Singapore, Singapore, 609606
    - Ng Teng Fong General Hospital
  - Singapore, Singapore, 169609
    - National Heart Centre (NHC) Singapore
  - Singapore, Singapore, 768828
    - Khootech Puat Hospital
Slovakiet
- - Banská Bystrica, Slovakiet, 97401
    - Stredoslovensky ustav srdcovych a cievnych chorob a.s
  - Bardejov, Slovakiet, 08501
    - Alian s.r.o.
  - Bratislava, Slovakiet, 811 02
    - Premedix Clinic
  - Brezno, Slovakiet, 977 01
    - Nemocnica s poliklinikou Brezno
  - Košice, Slovakiet, 040 11
    - Východoslovenský Ústav Srdcových A Cievnych Chorôb, A.S.
  - Košice, Slovakiet, 04001
    - Interno Kardio s r o
  - Košice, Slovakiet, 4022
    - Kardiologicka ambulancia CARDIO D&R s.r.o.
  - Lučenec, Slovakiet, 98439
    - KARDIO 1 s.r.o.
  - Martin, Slovakiet, 036 59
    - Univerzitna nemocnica Martin 1
  - Moldava nad Bodvou, Slovakiet, 4501
    - Kardiologicka ambulancia MEDI M&M s.r.o.
  - Nitra, Slovakiet, 95001
    - Kardiocentrum Nitra s.r.o.
  - Nové Zámky, Slovakiet, 94052
    - Cardioinvest s.r.o.
  - Svidník, Slovakiet, 08901
    - Interna SK s.r.o.
  - Zvolen, Slovakiet, 960 01
    - Nemocnica AGEL Zvolen a s
  - Žilina, Slovakiet, 01001
    - MEDIVASA s.r.o.
Spanien
- - Alicante, Spanien, 03010
    - Hosp. Gral. Univ. de Alicante
  - Barcelona, Spanien, 08025
    - Hosp. de La Santa Creu I Sant Pau
  - Barcelona, Spanien, 08003
    - Hosp. Del Mar
  - Barcelona, Spanien, 08036
    - Hosp Clinic de Barcelona
  - Barcelona, Spanien, 08035
    - Hosp Univ Vall D Hebron
  - El Palmar, Spanien, 30120
    - Hosp. Univ. Virgen de La Arrixaca
  - Gijón, Spanien, 33206
    - Hosp. de Cabuenes
  - Lleida, Spanien, 25198
    - Hosp. Univ. Arnau de Vilanova de Lleida
  - Madrid, Spanien, 28040
    - Hosp. Clinico San Carlos
  - Madrid, Spanien, 28041
    - Hosp. Univ. 12 de Octubre
  - Madrid, Spanien, 28034
    - Hosp. Univ. Ramon Y Cajal
  - Madrid, Spanien, 28046
    - Hosp. Univ. La Paz
  - Madrid, Spanien, 28006
    - Hosp. Univ. de La Princesa
  - Madrid, Spanien, 28660
    - Hosp. Univ. Hm Monteprincipe
  - Madrid, Spanien, 28003
    - Hosp. Virgen de La Luz
  - Manises, Spanien, 46940
    - Hosp. de Manises
  - Málaga, Spanien, 29010
    - Hosp Virgen de La Victoria
  - Pamplona, Spanien, 31008
    - Complejo Hosp. de Navarra
  - Santiago de Compostela, Spanien, 15706
    - Hosp. Clinico Univ. de Santiago
  - Tarragona, Spanien, 43007
    - Hosp. Univ. Joan Xxiii
  - Valencia, Spanien, 46014
    - Hosp. Gral. Univ. Valencia
  - Valencia, Spanien, 46010
    - Hosp. Clinico Univ. de Valencia 1
  - Vigo, Spanien, 36312
    - Hosp. Alvaro Cunqueiro
  - Zaragoza, Spanien, 50009
    - Hosp. Univ. Miguel Servet
Sydafrika
- - Cape Town, Sydafrika, 7500
    - TREAD Research
  - Cape Town, Sydafrika, 7530
    - Tiervlei Trial Centre
  - Cape Town, Sydafrika, 7500
    - Panorama MediClinic
  - Cape Town, Sydafrika, 7925
    - Groote Schur Hospital
  - Centurion, Sydafrika, 0157
    - Johese Clinical Research
  - Durban, Sydafrika, 4001
    - Durban Medical Centre
  - Johannesburg, Sydafrika, 2192
    - Garda, RA
  - Mossel Bay, Sydafrika, 6506
    - Eden Heart
  - Somerset West, Sydafrika, 7130
    - Dr J.M. Engelbrecht Trial Site
  - Somerset West, Sydafrika, 7130
    - Helderberg Research Institute
  - Worcester, Sydafrika, 6850
    - Clinical Projects Research SA (PTY) LTD
Sydkorea
- - Bucheon-si, Sydkorea, 14647
    - Bucheon St. Mary's Hospital
  - Busan, Sydkorea, 49241
    - Pusan National University Hospital
  - Busan, Sydkorea, 47392
    - Inje University Busan Paik Hospital
  - Busan, Sydkorea, 602 812
    - Dong-A University Hospital
  - Cheongju-si, Sydkorea, 28644
    - Chungbuk National University Hospital
  - Chuncheon, Sydkorea, 24289
    - Kangwon National University Hospital
  - Daegu, Sydkorea, 42601
    - Keimyung University Dongsan Hospital
  - Daejeon, Sydkorea, 35015
    - Chungnam National University Hospital
  - Daejeon, Sydkorea, 302-718
    - Konyang University Hospital
  - Gangseo-gu, Sydkorea, 7804
    - Ewha Woman's University Seoul Hospital
  - Goyang-si, Sydkorea, 10475
    - MyongJi Hospital
  - Gwangju, Sydkorea, 61469
    - Chonnam National University Hospital
  - Gyeonggi-do, Sydkorea, 13620
    - Seoul National University Bundang Hospital
  - Incheon, Sydkorea, 21565
    - Gachon University Gil Medical Center
  - Incheon, Sydkorea, 403-720
    - The Catholic University of Korea, Incheon St. Mary's Hospital
  - Sejong-si, Sydkorea, 30099
    - Chungnam National University Sejong Hospital
  - Seoul, Sydkorea, 03080
    - Seoul National University Hospital
  - Seoul, Sydkorea, 05505
    - Asan Medical Center
  - Seoul, Sydkorea, 02841
    - Korea University Anam Hospital
  - Seoul, Sydkorea, 06273
    - Gangnam Severance Hospital, Yonsei University Health System
  - Seoul, Sydkorea, 120-752
    - Severance Hospital Yonsei University Health System
  - Seoul, Sydkorea, 8308
    - Korea University Guro Hospital
  - Seoul, Sydkorea, 130 050
    - Kyung Hee University Hospital
  - Seoul, Sydkorea, 134-727
    - Kyung Hee University Hospital at Gangdong
  - Seoul, Sydkorea, 4763
    - Hanyang University Hospital
  - Seoul, Sydkorea, 05368
    - VHS medical center
  - Seoul, Sydkorea, 06591
    - Seoul St.Mary s Hospital
  - Wŏnju, Sydkorea, 220-701
    - Wonju Severance Christian Hospital
  - Yangsan, Sydkorea, 50612
    - Pusan National University Yangsan Hospital
Taiwan
- - Changhua, Taiwan, 50006
    - Changhua Christian Hospital
  - Kaohsiung City, Taiwan, 82445
    - E-Da Hospital
  - Kaohsiung City, Taiwan, 807
    - Kaohsiung Medical University Chung Ho Memorial Hospital
  - New Taipei City, Taiwan, 22060
    - Far Eastern Memorial Hospital
  - New Taipei City, Taiwan, 25160
    - Mackay Memorial Hospital
  - Taichung, Taiwan, 404327
    - China Medical University Hospital
  - Tainan, Taiwan, 71004
    - Chi Mei Medical Center Yong Kang
  - Taipei, Taiwan, 10002
    - National Taiwan University Hospital
  - Taipei, Taiwan, 11217
    - Taipei Veterans General Hospital
  - Taipei, Taiwan, 110
    - Taipei Medical University
  - Taipei, Taiwan, 112
    - Cheng Hsin General Hospital
  - Taipei, Taiwan, 106
    - Cathay General Hospital
  - Taipei, Taiwan, 116
    - Taipei Municipal Wanfang Hospital
  - Taipei, Taiwan, 114202
    - Tri-Service General Hospital
  - Taoyuan County, Taiwan, 33305
    - Chang Gung Memorial Hospital- Linkou
  - Yilan County, Taiwan, 260
    - National Yang-Ming University Hospital
Thailand
- - Bangkok, Thailand, 10400
    - Ramathibodi Hospital
  - Bangkoknoi, Thailand, 10700
    - Siriraj Hospital
  - Chiang Mai, Thailand, 50200
    - Maharaj Nakorn Chiang Mai Hospital
  - Nai Mueang Subdistrict Mueang, Thailand, 40000
    - Srinagarind Hospital
  - Pathum Wan, Thailand, 10330
    - King Chulalongkorn Memorial Hospital
Tjekkiet
- - Brno, Tjekkiet, 625 00
    - Fakultni nemocnice Brno
  - Brno, Tjekkiet, 636 00
    - Vojenska nemocnice Brno
  - Brno, Tjekkiet, 65691
    - Fakultni nemocnice u sv. Anny v Brne
  - Hradec Králové, Tjekkiet, 500 05
    - Fakultni nemocnice Hradec Kralove
  - Jihlava, Tjekkiet, 586 01
    - Kardiocentrum Vysocina CZ a.s.
  - Kolín, Tjekkiet, 280 02
    - Oblastní nemocnice Kolín
  - Liberec, Tjekkiet, 46001
    - Krajska nemocnice Liberec a.s.
  - Ostrava-Poruba, Tjekkiet, 708 52
    - Fakultni Nemocnice Ostrava
  - Pardubice, Tjekkiet, 530 03
    - Pardubicka krajska nemocnice a s
  - Pilsen, Tjekkiet, 304 60
    - Fakultni Nemocnice Plzen
  - Prague, Tjekkiet, 12808
    - Vseobecna fakultni nemocnice v Praze
  - Prague, Tjekkiet, 100 34
    - Fakultni nemocnice Kralovske Vinohrady
  - Prague, Tjekkiet, 169 02
    - Ustredni vojenske nemocnice Praha
  - Prague, Tjekkiet, 120 00
    - Kardiologie Vinohrady s r o
  - Prague, Tjekkiet, 14000
    - Institut klinicke a experimentalni mediciny
  - Slaný, Tjekkiet, 274 01
    - Nemocnice Slany
  - Třinec, Tjekkiet, 73961
    - Nemocnice AGEL - Podlesi a.s.
  - České Budějovice, Tjekkiet, 370 87
    - Nemocnice Ceske Budejovice a s
Tyrkiet (Türkiye)
- - Afyonkarahisar, Tyrkiet (Türkiye), 03200
    - Afyon Kocatepe University Medical Faculty
  - Ankara, Tyrkiet (Türkiye), 06100
    - Ankara University Medical Faculty
  - Ankara, Tyrkiet (Türkiye), 06010
    - Ankara Etlik Speciality Hospital
  - Ankara, Tyrkiet (Türkiye), 06800
    - Ankara Numune Research and Training Hospital
  - Bursa, Tyrkiet (Türkiye), 16330
    - Bursa Yuksek Ihtisas Training and Research Hospital
  - Eskişehir, Tyrkiet (Türkiye), 26480
    - Osmangazi University Medical Faculty
  - Istanbul, Tyrkiet (Türkiye), 34899
    - Marmara University Pendik Training Hospital
  - Istanbul, Tyrkiet (Türkiye), 34093
    - Bezmi Alem Vakif University Medical Faculty Hospital
  - Izmir, Tyrkiet (Türkiye), 35340
    - Dokuz Eylul University Medical Faculty
  - Karabük, Tyrkiet (Türkiye), 06100
    - Karabuk University Medical Faculty
  - Kayseri, Tyrkiet (Türkiye), 38039
    - Erciyes University Medical Faculty
  - Kütahya, Tyrkiet (Türkiye), 43040
    - Kutahya Health Science University Evliya Celebi Research and Training Hospital
  - Mersin, Tyrkiet (Türkiye), 33020
    - Mersin University Medical Faculty
  - Samsun, Tyrkiet (Türkiye), 55139
    - Ondokuz Mayis University
Tyskland
- - Bad Friedrichshall, Tyskland, 74177
    - Klinikum am Plattenwald
  - Bad Krozingen, Tyskland, 79189
    - Universitaetsklinikum Freiburg
  - Bad Krozingen, Tyskland, 79189
    - Universitaetsklinikum Freiburg 1
  - Bad Nauheim, Tyskland, 61231
    - Kerckhoff-Klinik Bad Nauheim
  - Berlin, Tyskland, 13353
    - Charite Campus Virchow
  - Berlin, Tyskland, 10249
    - Vivantes Klinikum im Friedrichshain
  - Berlin, Tyskland, 13509
    - Vivantes Humboldt Klinikum
  - Berlin, Tyskland, 12200
    - Charite Campus Benjamin Franklin
  - Beuel, Tyskland, 53225
    - GFO Kliniken Bonn, Betriebsstaette St. Marien
  - Bielefeld, Tyskland, 33604
    - Klinikum Bielefeld
  - Bitburg, Tyskland, 54634
    - Marienhausklinikum Eifel Bitburg
  - Bonn, Tyskland, 53127
    - Universitatsklinikum Bonn
  - Brandenburg an der Havel, Tyskland, 14770
    - Staedisches Klinikum Brandenburg
  - Bremen, Tyskland, 28277
    - Hospital Bremen Mitte
  - Coburg, Tyskland, 96450
    - Regiomed Klinikum Coburg
  - Dortmund, Tyskland, 44137
    - St. Johannes-Hospital
  - Dresden, Tyskland, 01067
    - Staedtisches Klinikum Dresden Standort Dresden Friedrichstadt
  - Erfurt, Tyskland, 99097
    - Katholisches Krankenhaus St. Josef gGmbH - Abtlg. für Gynäkologie
  - Frankfurt, Tyskland, 60590
    - Klinikum der Johann Wolfgang Goethe -Universitaet
  - Greifswald, Tyskland, 17475
    - Universitaetsmedizin Greifswald
  - Hamburg, Tyskland, 20246
    - Universitaetsklinikum Hamburg Eppendorf
  - Hamburg, Tyskland, 22307
    - Asklepios Klinik Barmbek
  - Hamburg, Tyskland, 22587
    - Asklepios Klinik St. Georg
  - Leverkusen, Tyskland, 51375
    - Klinikum Leverkusen gGmbH
  - Ludwigshafen, Tyskland, 67063
    - Herzzentrum Ludwigshafen
  - Lüdenscheid, Tyskland, 58515
    - Klinikum Luedenscheid
  - Magdeburg, Tyskland, 39120
    - Universitätsklinikum Magdeburg
  - Mainz, Tyskland, 55131
    - Universitatsmedizin der Johannes Gutenberg Universitat Mainz
  - Mainz, Tyskland, 55131
    - Katholisches Klinikum Mainz; Innere Medizin I- Kardiologie
  - Mannheim, Tyskland, 68167
    - Universitaetsklinikum Mannheim
  - Mönchengladbach, Tyskland, 41063
    - Kliniken Maria Hilf GmbH
  - Neuwied, Tyskland, 56564
    - Marienhaus Klinikum
  - Remscheid, Tyskland, 42859
    - Sana-Klinikum Remscheid GmbH
  - Rostock, Tyskland, 18057
    - Universitaetsmedizin Rostock
  - Tübingen, Tyskland, 72076
    - Universitaetsklinikum Tuebingen
  - Worms, Tyskland, 67550
    - Klinikum Worms gGmbH
Ungarn
- - Budapest, Ungarn, 1096
    - Gottsegen György Országos Kardiológiai Intézet
  - Budapest, Ungarn, 1085
    - Semmelweis Egyetem
  - Budapest, Ungarn, 1023
    - Budai Irgalmasrendi Korhaz
  - Budapest, Ungarn, 1106
    - Bajcsy-Zsilinszky Korhaz es Rendelointezet
  - Budapest, Ungarn, 1122
    - Semmelweis Egyetem Varosmajor Sziv es Ergyogyaszati Klinika
  - Debrecen, Ungarn, 4032
    - Debreceni Egyetem
  - Gyula, Ungarn, 5700
    - Bekes Megyei Kozponti Korhaz Pandy Kalman Tagkorhaz
  - Kaposvár, Ungarn, 7400
    - Somogy Megyei Kaposi Mór Oktató Kórház
  - Kecskemét, Ungarn, 6000
    - Bacs-Kiskun Megyei Korhaz
  - Pécs, Ungarn, 7624
    - Pecsi Tudomanyegyetem
  - Szeged, Ungarn, 6725
    - Szegedi Tudomanyegyetem Aok Szent-Gyorgyi Albert Klinikai Kozpont
  - Szekszárd, Ungarn, 7100
    - Tolna Megyei Balassa Janos Korhaz
  - Szolnok, Ungarn, 5000
    - Jasz Nagykun Szolnok Megyei Hetenyi Geza Korhaz Rendelointez
  - Szombathely, Ungarn, 9700
    - Markusovszky Egyetemi Oktatokorhaz
  - Zalaegerszeg, Ungarn, 8900
    - Belvarosi Egeszseghaz Kft. (Leda-Platan Maganklinika es Sebeszeti Kozpont)
Vietnam
- - Hanoi, Vietnam, 100000
    - Bach Mai hospital
  - Hanoi, Vietnam
    - 103 Military Hospital
  - Hanoi, Vietnam
    - Hanoi Medical University Hospital
  - Hanoi, Vietnam
    - Hanoi Heart Hospital
  - Hanoi, Vietnam, 100000
    - Tam Anh General Hospital
  - Ho Chi Minh City, Vietnam, 700000
    - People's Hospital 115
  - Ho Chi Minh City, Vietnam, 700000
    - Thong Nhat hospital
  - Ho Chi Minh City, Vietnam, 700000
    - Tam Anh Hospital
  - Ho Chi Minh City, Vietnam
    - Tam Duc Heart Hospital
Østrig
- - Braunau am Inn, Østrig, 5280
    - KH St.Josef Braunau am Inn
  - Feldkirch, Østrig, A-6807
    - Landeskrankenhaus Feldkirch
  - Graz, Østrig, 8036
    - Lkh-Univ. Klinikum Graz
  - Linz, Østrig, 4020
    - Krankenhaus der Elisabethinen Linz
  - Vienna, Østrig, 1090
    - AKH - Medizinische Universität Wien

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

18 år og ældre (Voksen, Ældre voksen)

Tager imod sunde frivillige

Ingen

Beskrivelse

Inklusionskriterier:

Deltagerne skal have en indekshændelse, der opfylder alle 3 af følgende kriterier inden for 7 dage før randomisering: a) klinisk syndrom i overensstemmelse med spontan hjerteiskæmi, b) diagnose af akut koronarsyndrom (ACS) (det vil sige myokardieinfarkt med ST-elevation) [STEMI], ikke-STEMI eller ustabil angina [UA]), c) forhøjelse af hjertebiomarkør (eksempel troponin I, troponin T, kreatinkinase-MB [CK-MB]) over den øvre normalgrænse som bestemt af lokalt laboratorium
Deltagerne skal have mindst 2 af følgende risikofaktorer: a) alder 65 år eller ældre, b) diabetes mellitus, c) tidligere myokardieinfarkt (MI) (bortset fra indeks ACS-hændelse), d) koronararteriesygdom med flere kar ( CAD), e) anamnese med koronararterie-bypass-operation (CABG) før indeks-ACS-hændelse, f) anamnese med perifer arteriesygdom (PAD) eller cerebrovaskulær sygdom (f.eks. carotis aterosklerose, intrakraniel arteriestenose, g) konservativ behandling (det er, ingen perkutan intervention [PCI] eller CABG efter indeks ACS-hændelse), h) En eller flere af følgende højrisiko angiografiske træk i) samlet stentlængde på mere end (>) 30 millimeter (mm), ii) trombotisk mållæsion, iii) bifurkationslæsion behandlet med mere end én stent, iv) forkalket mållæsion behandlet med aterektomi, v) behandling af obstruktiv venstre hoved- eller proksimal venstre hoved- eller proksimal venstre anterior nedadgående arterie for indeks ACS (eller klinisk diagnose af en anterior STEMI)
Alle kvindelige deltagere i den fødedygtige alder skal have en negativ højsensitiv serum beta-human choriongonadotropin (hCG) eller urintest ved screening
En kvindelig deltager må ikke være gravid, amme eller planlægge at blive gravid før 4 dage (5 halveringstider) efter den sidste dosis af undersøgelsesintervention

Ekskluderingskriterier:

MI sekundært til iskæmi på grund af enten øget iltbehov eller nedsat forsyning (type 2 MI) eller periprocedural MI som indeks ACS-hændelse
Planlagt CABG eller trinvis PCI efter randomisering
Enhver tilstand, der kræver kronisk antikoagulering efter efterforskerens skøn og/eller lokale retningslinjer
Tilstande med en signifikant øget risiko for blødning (eksempel, klinisk signifikant blødning inden for de foregående 3 måneder, kendt blødningsdiatese, et cetera)

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Primært formål: Behandling
Tildeling: Randomiseret
Interventionel model: Parallel tildeling
Maskning: Firedobbelt

Antal våben

Våben og indgreb

Deltagergruppe / Arm	Intervention / Behandling
Eksperimentel: Milvexian Deltagere tilmeldt inden for 7 dage efter et akut koronarsyndrom (ACS), som har gennemgået hjertekateterisering med perkutan intervention (PCI), eller som behandles konservativt med eller uden kateterisering, og som modtager trombocythæmmende behandling standard-of-care (enkelt blodpladehæmmende terapi [SAPT] eller dobbelt antitrombocytbehandling [DAPT]) som bestemt af investigator vil modtage milvexian 25 milligram (mg), oralt, to gange dagligt.	Medicin: Milvexian Milvexian vil blive administreret oralt. Andre navne: BMS-986177 JNJ-70033093
Placebo komparator: Placebo Deltagere, der er tilmeldt inden for 7 dage efter en ACS, som har gennemgået hjertekateterisering med PCI, eller som behandles konservativt med eller uden kateterisering, og som modtager trombocythæmmende terapi standard-of-care (SAPT eller DAPT) som bestemt af investigator vil modtage placebo oralt, to gange dagligt.	Andet: Placebo Placebo vil blive indgivet oralt.

Deltagergruppe / Arm

Intervention / Behandling

Eksperimentel: Milvexian

Deltagere tilmeldt inden for 7 dage efter et akut koronarsyndrom (ACS), som har gennemgået hjertekateterisering med perkutan intervention (PCI), eller som behandles konservativt med eller uden kateterisering, og som modtager trombocythæmmende behandling standard-of-care (enkelt blodpladehæmmende terapi [SAPT] eller dobbelt antitrombocytbehandling [DAPT]) som bestemt af investigator vil modtage milvexian 25 milligram (mg), oralt, to gange dagligt.

Medicin: Milvexian

Milvexian vil blive administreret oralt.

Andre navne:

BMS-986177
JNJ-70033093

Placebo komparator: Placebo

Deltagere, der er tilmeldt inden for 7 dage efter en ACS, som har gennemgået hjertekateterisering med PCI, eller som behandles konservativt med eller uden kateterisering, og som modtager trombocythæmmende terapi standard-of-care (SAPT eller DAPT) som bestemt af investigator vil modtage placebo oralt, to gange dagligt.

Andet: Placebo

Placebo vil blive indgivet oralt.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til den første forekomst af alvorlig kardiovaskulær hændelse (MACE) Tidsramme: Op til 3 år 6 måneder	Tid til første forekomst af enhver komponent i MACE vil blive rapporteret. MACE er en sammensætning af kardiovaskulær (CV) død, myokardieinfarkt (MI) og iskæmisk slagtilfælde.	Op til 3 år 6 måneder

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Tid til den første forekomst af Major Adverse Vascular Event (MAVE) Tidsramme: Op til 3 år 6 måneder	Tiden til den første forekomst af enhver komponent af MAVE vil blive rapporteret. MAVE er en sammensætning af CV-død, MI, iskæmisk slagtilfælde, alvorlig uønsket lemmerhændelse (MALE) og symptomatisk venøs tromboemboli (VTE).	Op til 3 år 6 måneder
Tid til den første forekomst af sammensat dødelighed af alle årsager (ACM), myokardieinfarkt (MI) og iskæmisk slagtilfælde Tidsramme: Op til 3 år 6 måneder	Tiden til den første forekomst af sammensat af ACM, MI og iskæmisk slagtilfælde vil blive rapporteret.	Op til 3 år 6 måneder
Tid til kardiovaskulær (CV) død Tidsramme: Op til 3 år 6 måneder	Tid til CV død vil blive rapporteret.	Op til 3 år 6 måneder
Tid til dødsfald af alle årsager (ACM) Tidsramme: Op til 3 år 6 måneder	Tid til ACM vil rapportere. ACM vil blive kategoriseret i CV-død, ikke-CV-død og død på grund af ukendt årsag.	Op til 3 år 6 måneder

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Janssen Research & Development, LLC

Samarbejdspartnere

Bristol-Myers Squibb

Efterforskere

Studieleder: Janssen Research & Development, LLC Clinical Trial, Janssen Research & Development, LLC

Publikationer og nyttige links

Den person, der er ansvarlig for at indtaste oplysninger om undersøgelsen, leverer frivilligt disse publikationer. Disse kan handle om alt relateret til undersøgelsen.

Generelle publikationer

Gibson CM, Bahit MC, Mehran R, Mehta SR, Lamee RA, Goto S, Weitz JI, Horrow J, Barnathan ES, Harrington RA, Mahaffey KW, Lam CSP, Pieper KS, Johnston SC, Hankey GJ, Plotnikov AN, Li D, Deng H, Steg PG; Librexia ACS Committees and Investigators.. Oral factor xia inhibitor milvexian after a recent acute coronary syndrome: Rationale and design of the phase 3 (Librexia ACS). Am Heart J. 2025 Jul;285:21-28. doi: 10.1016/j.ahj.2025.02.011. Epub 2025 Feb 20.

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

7. april 2023

Primær færdiggørelse (Faktiske)

6. februar 2026

Studieafslutning (Faktiske)

6. februar 2026

Datoer for studieregistrering

Først indsendt

23. februar 2023

Først indsendt, der opfyldte QC-kriterier

23. februar 2023

Først opslået (Faktiske)

6. marts 2023

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

6. juli 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

2. juli 2026

Sidst verificeret

1. juli 2026

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

CR109271
70033093ACS3003 (Anden identifikator: Janssen Research & Development, LLC)
2022-501418-69-00 (Registry Identifier: EUCT number)

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Datadelingspolitikken for Janssen Pharmaceutical Companies of Johnson & Johnson er tilgængelig på www.janssen.com/clinical-trials/transparency. Som bemærket på dette websted, kan anmodninger om adgang til undersøgelsesdata indsendes gennem Yale Open Data Access (YODA) projektwebsted på yoda.yale.edu

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

Ingen

Disse oplysninger blev hentet direkte fra webstedet clinicaltrials.gov uden ændringer. Hvis du har nogen anmodninger om at ændre, fjerne eller opdatere dine undersøgelsesoplysninger, bedes du kontakte register@clinicaltrials.gov. Så snart en ændring er implementeret på clinicaltrials.gov, vil denne også blive opdateret automatisk på vores hjemmeside .

En undersøgelse af Milvexian hos deltagere efter et nyligt akut koronarsyndrom (LIBREXIA-ACS)

En fase 3, randomiseret, dobbeltblind, placebokontrolleret, hændelsesdrevet undersøgelse for at demonstrere effektiviteten og sikkerheden af ​​Milvexian, en oral faktor XIa-hæmmer, efter et nyligt akut koronarsyndrom

Studieoversigt

Status

Betingelser

Intervention / Behandling

Undersøgelsestype

Tilmelding (Faktiske)

Fase

Kontakter og lokationer

Studiesteder

Deltagelseskriterier

Berettigelseskriterier

Aldre berettiget til at studere

Tager imod sunde frivillige

Beskrivelse

Studieplan

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal våben

Våben og indgreb

Deltagergruppe / Arm

Intervention / Behandling

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Sekundære resultatmål

Resultatmål

Foranstaltningsbeskrivelse

Tidsramme

Samarbejdspartnere og efterforskere

Sponsor

Samarbejdspartnere

Efterforskere

Publikationer og nyttige links

Generelle publikationer

Datoer for undersøgelser

Studer store datoer

Studiestart (Faktiske)

Primær færdiggørelse (Faktiske)

Studieafslutning (Faktiske)

Datoer for studieregistrering

Først indsendt

Først indsendt, der opfyldte QC-kriterier

Først opslået (Faktiske)

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

Sidst verificeret

Mere information

Begreber relateret til denne undersøgelse

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

IPD-planbeskrivelse

Lægemiddel- og udstyrsoplysninger, undersøgelsesdokumenter

Studerer et amerikansk FDA-reguleret lægemiddelprodukt

Studerer et amerikansk FDA-reguleret enhedsprodukt

En fase 3, randomiseret, dobbeltblind, placebokontrolleret, hændelsesdrevet undersøgelse for at demonstrere effektiviteten og sikkerheden af Milvexian, en oral faktor XIa-hæmmer, efter et nyligt akut koronarsyndrom