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TransThoracic Ultrasound for Descending Aortic Aneurysms (THORUS)

3. august 2026 opdateret af: Imperial College London

Feasibility, Accuracy and Reproducibility of Ultrasound in Aneurysms of the Descending Thoracic Aorta

The goal of this observational study is to assess the applicability of non-invasive ultrasound in aneurysms of the descending thoracic aorta.

The main question it aims to answer is:

What is the feasibility of Ultrasound to visualise the Descending Thoracic Aorta, and can this imaging modality accurately measure the maximum size of aneurysms and residual sacs with acceptable reproducibility?

Participants are having their diagnosis confirmed or excluded by conventional imaging techniques (CT scans). Participants receive exactly the same standard of care regardless of their participation. The study offers an additional ultrasound scan, and the results will be compared with previous imaging.

Studieoversigt

Status

Ikke rekrutterer endnu

Betingelser

Detaljeret beskrivelse

Aneurysms of the aortic artery are a significant public health issue. The number of newly diagnosed aneurysms of the thoracic aorta is on the rise, and aneurysm rupture is a catastrophic event associated with high mortality rates. The most proximal sections of the aorta (ascending and the aortic arch) are routinely scanned by echocardiography practitioners. The abdominal aorta is also easily visualised on transabdominal ultrasound, and there is a screening programme in the UK that is highly cost-effective and reduced the aneurysm-related number of deaths. However, the portion of the aorta in the chest (descending thoracic aorta) is not routinely assessed by ultrasound practitioners.

The diagnosis of descending thoracic aneurysms relies mostly on imaging techniques that use ionising radiation. In addition, these techniques are expensive and may not be widely available in some regions. In contrast, ultrasound is a non-invasive technique that allows visualisation of most parts of the body. Ultrasound machine suppliers have invested in better systems and transducers over the years and visualisation of the descending thoracic aorta may now be possible.

The main aims of this study are to assess the feasibility (Part 1), accuracy (Part 2) and reproducibility (Part 3) ultrasound in the diagnosis and monitoring of descending thoracic aortic aneurysms. Participants will be recruited from the vascular lab and outpatient clinics, and diameters of the descending thoracic aorta will be measured with non-invasive ultrasound. Data obtained from study measurements will be compared with computed tomography scans that patients had as part of their standard of care.

If the feasibility, accuracy and reproducibility of Ultrasound are clearly demonstrated, routine ultrasound scans of the descending thoracic aorta may be suggested.

Undersøgelsestype

Observationel

Tilmelding (Anslået)

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Navn: Carlos Pinho, PhD Student
Telefonnummer: +44 20 3312 3374
E-mail: cv1026@ic.ac.uk

Undersøgelse Kontakt Backup

Navn: Cheuk Fund Wong
Telefonnummer: +44 20 7594 9832
E-mail: rgit@imperial.ac.uk

Studiesteder

Det Forenede Kongerige
- London
  - London, London, Det Forenede Kongerige, W2 1NY
    - Imperial College Healthcare NHS Trust - St Mary's Hospital
    - Kontakt:
      
      Carlos Pinho, PhD Student
      
      Telefonnummer: +44 20 3312 3374
      
      E-mail: cv1026@ic.ac.uk
    - Kontakt:
      
      Cheuk Fund Wong
      
      Telefonnummer: +44 20 7594 9832
      
      E-mail: rgit@imperial.ac.uk
    - Ledende efterforsker:
      
      Carlos Pinho, PhD Student

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

Voksen
Ældre voksen

Tager imod sunde frivillige

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

All Participants will receive a single Ultrasound scan as part of this study. All Patients had at least one CT scan of the thoracic aorta prior to the study as part of their standard of care. No additional radiation or invasive imaging techniques will be used in the Thorus study. The data obtained from the CT will be analysed by an independent reviewer and compared with Ultrasound measurements. Participants will be recruited prospectively from a single NHS Trust in London - Imperial College Healthcare NHS Trust.

Beskrivelse

Inclusion Criteria:

Patients with diagnosed AAA or other vascular condition attending the vascular scanning department for routine ultrasound and confirmed healthy DTA (Control group).
Patients with known DTAA (including Type B dissection) or patients who had TEVAR previously (Case group).
Patients who have had CT as part of their standard of care.
Patients able to tolerate the scan (Lying in supine position).
Adults aged 18 or over.
Willing to provide consent.

Exclusion Criteria:

Patient under 18 years of age.
Previous thoracic surgery or body deformity (severe kyphosis, scoliosis, pleural effusion or chest wall trauma).
Patients without previous imaging of the thoracic aorta.
Life expectancy <2 years.
Pregnant Women.
Patients unwilling to provide consent or unable to comply with study requirements.
Patients too frail to travel to routine outpatient appointments.
Inability to attend the appointment due to time constraints or other commitments.
Although rare, ultrasound contraindications as described in the scanning protocol are also exclusion criteria.

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Antal grupper/kohorter

Kohorter og interventioner

Gruppe / kohorte
CONTROLS Patients with healthy DTA (30 patients)
CASES Patients with DTAA or TEVAR (30 patients)

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Part 1 - Feasibility - Proportion of participants with successful ultrasound measurement of the diameter of the descending thoracic aorta Tidsramme: Day 1 - At the single ultrasound study visit.	Number and percentage of participants in whom the descending thoracic aortic diameter can be obtained by transthoracic ultrasound. The units of Measure are total number and percentages.	Day 1 - At the single ultrasound study visit.
Part 1 - Feasibility - Length of the descending thoracic aorta by Ultrasound Tidsramme: Day 1 - At the single ultrasound study visit.	Total length of the descending thoracic aorta from the aortic isthmus to the coeliac axis. The unit of Measure is Centimetres (cms).	Day 1 - At the single ultrasound study visit.
Part 1 - Feasibility - Ultrasound Quality Score Tidsramme: Day 1 - At the single ultrasound study visit.	Number of ultrasound windows that allow visualisation of the descending thoracic aorta (0 to 3 windows) and allocation of a quality score. The Unit of Measure is a score created for this study (0-Windows: No views; 1 window: Poor; 2 windows: Moderate; 3 windows: Good). Higher scores mean better image quality.	Day 1 - At the single ultrasound study visit.
Part 2 - Accuracy - Comparision between Transthoracic Ultrasound and CT Tidsramme: Day 1 - At the single ultrasound study visit.	Calculate mean differences and limits of agreement between TUS and CT. Achieve high sensitivity and specificity.	Day 1 - At the single ultrasound study visit.
Part 3 - Reproducibility - Intraclass correlation coefficient Tidsramme: Day 1 - At the single ultrasound study visit.	Calculate inter- and intra-operator variability by intraclass correlation coefficient (ICC). The study aims to achieve good or excellent reliability.	Day 1 - At the single ultrasound study visit.

Sekundære resultatmål

Resultatmål	Foranstaltningsbeskrivelse	Tidsramme
Part 1 - Feasibility - Factors limiting visualisation of the Descending Thoracic Aorta Tidsramme: Day 1 - At the single ultrasound study visit.	Number and percentages of participants in whom limiting factors such as body habitus or rib shadowing are reported after the ultrasound test. The units of measure are the number of participants with raised BMI (kg/m^2) and acoustic shadowing due to bone density.	Day 1 - At the single ultrasound study visit.
Part 1 - Feasibility - Duration of Ultrasound Examination Tidsramme: Day 1 - At the single ultrasound study visit.	Total time needed to complete the ultrasound scan of the descending thoracic aorta. The unit of measure is minutes.	Day 1 - At the single ultrasound study visit.
Part 1 - Feasibility - Patient Feedback Questionnaire Tidsramme: Day 1 - At the single ultrasound study visit.	Scores are obtained from the patient feedback questionnaire that was created specifically for this study and consists of 5 questions relating to comfort, tolerability and overall experience of the ultrasound scan. The unit of measure is a score ranging from 1-Strongly Disagree to 5-Strongly Agree. Higher scores mean better patient satisfaction.	Day 1 - At the single ultrasound study visit.

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Imperial College London

Efterforskere

Studiestol: Professor Colin Bicknell, Imperial College London

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Anslået)

7. september 2026

Primær færdiggørelse (Anslået)

5. april 2027

Studieafslutning (Anslået)

3. april 2028

Datoer for studieregistrering

Først indsendt

28. juli 2026

Først indsendt, der opfyldte QC-kriterier

3. august 2026

Først opslået (Faktiske)

7. august 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)