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Physical Profile of Cervicogenic Headache: Comparison With Neck Pain and Healthy Controls

20. august 2026 opdateret af: fatih bali, Istanbul Medipol University Hospital

A Multidimensional Physical Profile of Cervicogenic Headache: A Cross-Sectional Comparison With Nonspecific Neck Pain and Healthy Controls

The goal of this observational study is to compare physical findings across three adult groups. Cervicogenic headache (CGH) is a headache linked to a problem in the neck. Neck pain may affect posture, muscle function, grip strength, and sensitivity to pressure. Researchers do not know whether CGH has a distinct pattern of these findings.

The main questions are:

  • Do posture, grip strength, muscle stiffness, elasticity, and pressure sensitivity differ among the groups?
  • Are any differences more closely associated with CGH than with neck pain?

Researchers will compare adults ages 25 through 60. One group will include people with CGH lasting at least three months. Another group will include people with neck pain lasting at least six months. People in the neck pain group will have no headaches. Healthy participants will have no neck pain or headaches.

Researchers will not provide treatment or change participants' usual care. Each participant will complete one study visit lasting about 15 minutes. Participants will:

  • Answer short questions about their health and pain
  • Stand while researchers measure their head and neck posture
  • Squeeze a device that measures grip strength
  • Complete brief tests of neck muscle stiffness and elasticity
  • Tell researchers when applied pressure first becomes painful

Researchers will compare results across the three groups. The findings may guide future CGH assessment and treatment research.

Studieoversigt

Status

Rekruttering

Betingelser

Undersøgelsestype

Observationel

Tilmelding (Anslået)

135

Kontakter og lokationer

Dette afsnit indeholder kontaktoplysninger for dem, der udfører undersøgelsen, og oplysninger om, hvor denne undersøgelse udføres.

Studiekontakt

Studiesteder

Deltagelseskriterier

Forskere leder efter personer, der passer til en bestemt beskrivelse, kaldet berettigelseskriterier. Nogle eksempler på disse kriterier er en persons generelle helbredstilstand eller tidligere behandlinger.

Berettigelseskriterier

Aldre berettiget til at studere

  • Voksen

Tager imod sunde frivillige

Ja

Prøveudtagningsmetode

Ikke-sandsynlighedsprøve

Studiebefolkning

The study population consists of adults aged 25-60 years recruited at the study site in Istanbul, Türkiye. Participants are classified into three groups according to predefined clinical criteria. The cervicogenic headache group includes individuals diagnosed by a physician according to the International Classification of Headache Disorders, 3rd edition. The chronic nonspecific neck pain group includes individuals with neck pain lasting at least 6 months and no headache. The healthy control group includes individuals without neck pain or headache. Participants receive no study intervention and complete one questionnaire-based and instrument-based assessment session.

Beskrivelse

  • Inclusion Criteria:
  • Aged 25 to 60 years
  • Able to provide written informed consent
  • Meeting the criteria for one of the following groups:
  • Cervicogenic headache: physician diagnosis according to the International Classification of Headache Disorders, 3rd edition, with symptoms lasting at least 3 months
  • Chronic nonspecific neck pain: neck pain lasting at least 6 months without headache
  • Healthy control: no neck pain or headache

Exclusion Criteria:

  • Receipt of physiotherapy for headache or neck pain during the previous 6 months
  • Diagnosis of a headache disorder other than cervicogenic headache, including migraine or tension-type headache, or a diagnosis of trigeminal neuralgia
  • History of cervical spine surgery or significant cervical trauma
  • Current or previous diagnosis of a tumor or cancer
  • Serious cardiovascular, cerebrovascular, hematological, metabolic, neurological, or psychiatric disorder
  • Rheumatoid arthritis
  • Congenital cervical abnormality
  • Cervical spondylolisthesis or cervical instability
  • Active infection
  • Temporomandibular joint dysfunction
  • Dizziness or visual disturbance accompanying headache
  • Any clinical red flag suggesting serious cervical pathology
  • Pregnancy or breastfeeding
  • Upper-extremity injury, surgery, or another condition affecting handgrip strength
  • Serious musculoskeletal disorder affecting cervical posture or muscle measurements
  • Inability to complete the questionnaire-based or instrument-based assessments

Studieplan

Dette afsnit indeholder detaljer om studieplanen, herunder hvordan undersøgelsen er designet, og hvad undersøgelsen måler.

Hvordan er undersøgelsen tilrettelagt?

Design detaljer

Kohorter og interventioner

Gruppe / kohorte
Cervicogenic Headache Group
Adults aged 25-60 years with cervicogenic headache diagnosed by a physician according to the International Classification of Headache Disorders, 3rd edition (ICHD-3), and symptoms lasting at least 3 months. Participants undergo one questionnaire-based and instrument-based assessment session. No intervention is assigned.
Chronic Nonspescific Neck Pain Group
Adults aged 25-60 years with chronic nonspecific neck pain lasting at least 6 months and no headache. Participants undergo one questionnaire-based and instrument-based assessment session. No intervention is assigned.
Healthy Control Group
Adults aged 25-60 years with no neck pain or headaches. Participants undergo one questionnaire-based and instrument-based assessment session. No intervention is assigned.

Hvad måler undersøgelsen?

Primære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Bilateral Upper Trapezius Muscle Stiffness
Tidsramme: During the single assessment session at enrollment
Upper trapezius muscle stiffness will be assessed bilaterally using the MyotonPRO device. Three consecutive measurements will be obtained at the midpoint between the C7 spinous process and the lateral border of the acromion. The mean of the three measurements will be used. Stiffness will be expressed in newtons per meter (N/m), with higher values indicating greater stiffness.
During the single assessment session at enrollment
Bilateral Upper Trapezius Logarithmic Decrement
Tidsramme: During the single assessment session at enrollment
Upper trapezius logarithmic decrement will be assessed bilaterally using the MyotonPRO device at the same standardized measurement site. Three consecutive measurements will be obtained on each side, and their mean will be used. Logarithmic decrement is a dimensionless inverse indicator of tissue elasticity, with lower values indicating greater elasticity.
During the single assessment session at enrollment

Sekundære resultatmål

Resultatmål
Foranstaltningsbeskrivelse
Tidsramme
Bilateral Handgrip Strength
Tidsramme: During the single assessment session at enrollment
Bilateral handgrip strength will be measured using a Jamar Hydraulic Hand Dynamometer set to the second handle position. Participants will perform three maximal contractions with each hand in a standardized seated position. The highest value for each hand will be recorded in kilograms, with higher values indicating greater handgrip strength.
During the single assessment session at enrollment
Bilateral Upper Trapezius Pressure Pain Threshold
Tidsramme: During the single assessment session at enrollment
Pressure pain threshold will be measured bilaterally over the upper trapezius using a handheld pressure algometer with a 1-cm² probe. The measurement site will be the midpoint between the C7 spinous process and the lateral border of the acromion. Pressure will gradually increase until the participant first reports pain. Values will be recorded in kg/cm², with higher values indicating a higher pressure pain threshold.
During the single assessment session at enrollment
Bilateral Suboccipital Pressure Pain Threshold
Tidsramme: During the single assessment session at enrollment
Pressure pain threshold will be measured bilaterally over the suboccipital region using a handheld pressure algometer with a 1-cm² probe. The measurement site will be located 2 cm lateral to the C2 spinous process. Pressure will gradually increase until the participant first reports pain. Values will be recorded in kg/cm², with higher values indicating a higher pressure pain threshold.
During the single assessment session at enrollment
Tragus-to-Wall Distance
Tidsramme: During the single assessment session at enrollment
Tragus-to-wall distance will be measured in millimeters using a tape measure. Participants will stand with their heels, sacrum, and thoracic spine resting comfortably against a wall while maintaining a natural head position. The distance between the wall and the tragus will be recorded. Greater distances indicate greater forward positioning of the head.
During the single assessment session at enrollment
Craniovertebral Angle
Tidsramme: During the single assessment session at enrollment
The craniovertebral angle will be measured in degrees using a universal goniometer. The fulcrum will be positioned over the lateral projection of the C7 spinous process. The stationary arm will remain parallel to the floor, and the movable arm will point toward the tragus. Three measurements will be obtained, and their mean will be used. Smaller angles indicate greater forward head posture.
During the single assessment session at enrollment

Samarbejdspartnere og efterforskere

Det er her, du vil finde personer og organisationer, der er involveret i denne undersøgelse.

Sponsor

Istanbul Medipol University Hospital

Samarbejdspartnere

Istanbul Kent University

Datoer for undersøgelser

Disse datoer sporer fremskridtene for indsendelser af undersøgelsesrekord og resumeresultater til ClinicalTrials.gov. Studieregistreringer og rapporterede resultater gennemgås af National Library of Medicine (NLM) for at sikre, at de opfylder specifikke kvalitetskontrolstandarder, før de offentliggøres på den offentlige hjemmeside.

Studer store datoer

Studiestart (Faktiske)

21. april 2026

Primær færdiggørelse (Anslået)

1. oktober 2026

Studieafslutning (Anslået)

1. oktober 2026

Datoer for studieregistrering

Først indsendt

17. august 2026

Først indsendt, der opfyldte QC-kriterier

17. august 2026

Først opslået (Faktiske)

20. august 2026

Opdateringer af undersøgelsesjournaler

Sidste opdatering sendt (Faktiske)

21. august 2026

Sidste opdatering indsendt, der opfyldte kvalitetskontrolkriterier

20. august 2026

Sidst verificeret

1. august 2026

Mere information

Begreber relateret til denne undersøgelse

Nøgleord

Yderligere relevante MeSH-vilkår

Andre undersøgelses-id-numre

  • E-10840098-50.04-2858

Plan for individuelle deltagerdata (IPD)

Planlægger du at dele individuelle deltagerdata (IPD)?

INGEN

IPD-planbeskrivelse

Individual participant data will not be shared. Study findings will be reported only in aggregate form through scientific publications and presentations.

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