Effectiveness of a Cognitive Training Program (UMAM Method) in Elderly People Without Dementia
lauantai 25. tammikuuta 2020 päivittänyt: Madrid Salud
Cognitive Training in Elders Without Dementia Using UMAM Method. Genetic, Brain Volume and Cognitive Reserve Predictors: A Randomized Controlled Study
The study is oriented to analyze the effectiveness of a cognitive training method (UMAM) on cognitive functions, subjective memory and mood state in elderly people without dementia.
On the other hand, the study aims to examine whether variables such as cognitive reserve (e.g.
educational level), APOE genotype and intracranial volume are related to increased benefit after the intervention.
The researchers hope to find that greater cognitive reserve, not having the APOE allele ε4, and a greater volume of memory-related brain areas, are associated with better outcomes after the cognitive intervention.
Tutkimuksen yleiskatsaus
Tila
Valmis
Interventio / Hoito
Opintotyyppi
Interventio
Ilmoittautuminen (Todellinen)
199
Vaihe
- Ei sovellettavissa
Yhteystiedot ja paikat
Tässä osiossa on tutkimuksen suorittajien yhteystiedot ja tiedot siitä, missä tämä tutkimus suoritetaan.
Opiskelupaikat
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Madrid, Espanja, 28006
- Centro de Prevención del Deterioro Cognitivo
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Osallistumiskriteerit
Tutkijat etsivät ihmisiä, jotka sopivat tiettyyn kuvaukseen, jota kutsutaan kelpoisuuskriteereiksi. Joitakin esimerkkejä näistä kriteereistä ovat henkilön yleinen terveydentila tai aiemmat hoidot.
Kelpoisuusvaatimukset
Opintokelpoiset iät
60 vuotta ja vanhemmat (Aikuinen, Vanhempi Aikuinen)
Hyväksyy terveitä vapaaehtoisia
Ei
Sukupuolet, jotka voivat opiskella
Kaikki
Kuvaus
Inclusion Criteria:
- Being over 60 years old.
- Having a global cognitive performance > 23 in the Mini Mental State Examination Test.
- Having no history of neurological or serious psychiatric disorders (severe psycho-affective disorders and psychosis or other psychiatric disorders like alcoholism).
Exclusion Criteria:
- Chronic use of anxiolytics.
- Chronic use of neuroleptics.
- Chronic use of anticonvulsants.
- Having hearing or vision impairments that would preclude testing.
- Magnetic Resonance Imaging (MRI) contraindications.
Opintosuunnitelma
Tässä osiossa on tietoja tutkimussuunnitelmasta, mukaan lukien kuinka tutkimus on suunniteltu ja mitä tutkimuksella mitataan.
Miten tutkimus on suunniteltu?
Suunnittelun yksityiskohdat
- Ensisijainen käyttötarkoitus: Ennaltaehkäisy
- Jako: Satunnaistettu
- Inventiomalli: Rinnakkaistehtävä
- Naamiointi: Ei mitään (avoin tarra)
Aseet ja interventiot
Osallistujaryhmä / Arm |
Interventio / Hoito |
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Kokeellinen: Experimental Group
The experimental group carried out a 30-session multi-factorial group memory training program (UMAM method), with a frequency of three weekly sessions of 90 minutes each. The training program consists of four modules: 1- Stimulation of cognitive processes; learning and practicing internal memory strategies and solving everyday forgetfulness; 2- Instruction in basic concepts about memory; 3- Intervention on daily living and forgetting experiences, using internal and external strategies to solve everyday memory failures; 4- Metacognition or metamemory: the subjects were to reflect about their cognitive failures by analyzing the causes and variables of those failures. In addition, the experimental group followed the standard activities in which all users attending the Center are involved (planned interviews, dialogue-conferences, general health recommendations, etc.). |
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Ei väliintuloa: Control Group
The Control Group followed the standard activities in which all users attending the Center are involved (planned interviews, dialogue-conferences, general health recommendations, etc.).
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Mitä tutkimuksessa mitataan?
Ensisijaiset tulostoimenpiteet
Tulosmittaus |
Toimenpiteen kuvaus |
Aikaikkuna |
|---|---|---|
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Change in general cognition
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in general cognition, assessed with the Mini Mental State Examination Test (MMSE) and the 7 Minutes Test (7M).The score ranges from 0 to 30 points (MMSE) and from 0 to 89 points (7M).
In both cases, the higher scores indicate a better outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in verbal memory
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in verbal memory, assessed with the Word List Test of the Wechsler Memory Scale-III.
The score ranges from 0 to 48 points.
Higher scores indicate a better outcome.
|
This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
|
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Change in logical memory
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in immediate and delayed logical memory, assessed with the Logical Memory Test (immediate and delayed units) of the Wechsler Memory Scale-III.
The score ranges from 0 to 75 points (immediate units) and from 0 to 50 (delayed units).
Higher scores indicate a better outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in visual memory
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in visual memory, assessed with the Rey memory test (form B).
The score ranges from 0 to 22 points.
Higher scores indicate a better outcome.
|
This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in daily memory
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in daily memory, assessed with the Rivermead Behavioral Memory Test.
The score ranges from 0 to 24 points.
Higher scores indicate a better outcome.
|
This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
|
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Change in attentional amplitude
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in attentional amplitude, assessed with the Direct Digit Test of the Wechsler Memory Scale-III.
The score ranges from 0 to 16 points.
Higher scores indicate a better outcome.
|
This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
|
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Change in attentional control
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in attentional control, assessed with the Inverse Digit Test of the Wechsler Memory Scale-III.
The score ranges from 0 to 14 points.
Higher scores indicate a better outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in attention and processing speed
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in attention, assessed with the Trail Making Test, form A. The score ranges from 0 to 200 points.
Higher scores indicate a worse outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in alternating attention and planning
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in alternating attention and planning, assessed with the Trail Making Test, form B. The score ranges from 0 to 400 points.
Higher scores indicate a worse outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in naming ability (language)
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in naming ability, assessed with the Boston Naming Test.
The score ranges from 0 to 60 points.
Higher scores indicate a better outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in verbal fluency (language)
Aikaikkuna: This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in phonologic and semantic verbal fluency, assessed with the Phonological Verbal Fluency Test and the Semantic Fluency Test respectively.
The score goes from zero onwards (there is no upper limit).
Higher scores indicate a better outcome.
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This cognitive variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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Change in subjective memory
Aikaikkuna: This variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in Subjective Memory, assessed with the Memory Failures of Everyday Questionnaire.The score ranges from 0 to 56 points.
Higher scores indicate a worse outcome.
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This variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
|
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Change in mood
Aikaikkuna: This variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The measure of the post-intervention change in mood, assessed with the Geriatric Depression Scale.
The score ranges from 0 to 15 points.
Higher scores indicate a worse outcome.
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This variable was assessed before and after the intervention. The interval between the pre and post-intervention assessment was 6 months.
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The Cognitive Reserve as a predictor of change.
Aikaikkuna: Cognitive Reserve was assessed in the pre-intervention assessment.
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The Cognitive Reserve was assessed with Rami Test.
The score ranges from 0 to 25 points.
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Cognitive Reserve was assessed in the pre-intervention assessment.
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The Genetic Profile as a predictor of change.
Aikaikkuna: The Genetic Profile was assessed in the pre-intervention assessment.
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The Genetic Profile was obtained by genetic analysis employing a blood test.
APOE gene has been coded as 1 (meaning no ε4 allele), or 0 (for at least one ε4 allele).
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The Genetic Profile was assessed in the pre-intervention assessment.
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The Brain Volume as a predictor of change.
Aikaikkuna: The Brain Volume was assessed in the pre-intervention assessment.
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The Brain Volume (total gray volume, left hippocampus, right hippocampus and total intracranial volume) was assessed by magnetic resonance imaging.
Unit of measure: mm3.
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The Brain Volume was assessed in the pre-intervention assessment.
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Opi tärkeimmät päivämäärät
Opiskelun aloitus (Todellinen)
Tiistai 1. lokakuuta 2013
Ensisijainen valmistuminen (Todellinen)
Perjantai 1. toukokuuta 2015
Opintojen valmistuminen (Todellinen)
Perjantai 1. toukokuuta 2015
Opintoihin ilmoittautumispäivät
Ensimmäinen lähetetty
Sunnuntai 22. joulukuuta 2019
Ensimmäinen toimitettu, joka täytti QC-kriteerit
Lauantai 25. tammikuuta 2020
Ensimmäinen Lähetetty (Todellinen)
Keskiviikko 29. tammikuuta 2020
Tutkimustietojen päivitykset
Viimeisin päivitys julkaistu (Todellinen)
Keskiviikko 29. tammikuuta 2020
Viimeisin lähetetty päivitys, joka täytti QC-kriteerit
Lauantai 25. tammikuuta 2020
Viimeksi vahvistettu
Keskiviikko 1. tammikuuta 2020
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