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Plant-based Diet in Older People: What Consequences for Muscle Health? (MYOVEG)

26 juin 2026 mis à jour par: University Hospital, Clermont-Ferrand
This randomized, controlled, two-arm clinical study aims to determine how increasing the proportion of plant-based foods in the diet affects skeletal muscle strength, mass and function, protein metabolism, microbiota and key metabolic markers in healthy older men and women. We hypothesize that diets enriched with animal-based foods will maintain maximal quadriceps strength-the primary outcome of the study-more effectively after the 3-month nutritional intervention than plant-based diets. Proteomic analyses will be performed to identify molecular mechanisms and potential muscle biomarkers reflecting metabolic adaptations of skeletal muscle to plant-enriched diets. In addition, metabolic health markers and micronutrient status will be evaluated to better understand the overall health effects of dietary plant-based transition in older adults.

Aperçu de l'étude

Statut

Pas encore de recrutement

Les conditions

Intervention / Traitement

Description détaillée

This exploratory, open-label, randomized, controlled, two-arm clinical study aims to evaluate how increasing the proportion of plant-based foods in the diet affects skeletal muscle health in older adults. The primary objective is to assess the impact of a plant-enriched diet on physical performance, specifically maximal quadriceps strength after a 3-month nutritional intervention.

Secondary objectives are to determine the effects of a plant-enriched diet on: (1) whole-body and muscle protein metabolism, (2) modifications in the skeletal muscle proteome and metabolome, (3) functional capacities, (4) body composition, (5) gut microbiota composition, and (6) sex-related differences in metabolic adaptability. The study will compare diets containing different proportions of plant-based foods in healthy older men and women.

Participants will undergo medical evaluation, nutritional follow-up, body composition measurements, muscle function testing, indirect calorimetry, and biological sampling including blood tests, and microbiota profiling. BBlood samples will be collected for proteomic and metabolomic analyses to identify molecular pathways and potential muscle biomarkers associated with adaptations to plant-enriched diets. In parallel, circulating amino acid concentrations will be measured to assess protein bioavailability, and blood samples will be incubated with skeletal muscle cells to evaluate the anabolic potential of the ingested proteins. Digestive tolerance, micronutrient status, and metabolic health markers will also be monitored.

The procedures are associated with minimal anticipated risks. Blood sampling may cause bruising and indirect calorimetry may result in mild discomfort. Plant-enriched diets may induce transient digestive symptoms or weight loss, which will be closely monitored. Participants experiencing clinically significant weight loss will be withdrawn from the intervention and followed until stabilization.

The findings of this study may strengthen public health recommendations promoting sustainable dietary transitions in older adults and help develop nutritional strategies aimed at maintaining optimal muscle health and supporting healthy aging.

Type d'étude

Interventionnel

Inscription (Estimé)

60

Phase

  • N'est pas applicable

Contacts et emplacements

Cette section fournit les coordonnées de ceux qui mènent l'étude et des informations sur le lieu où cette étude est menée.

Coordonnées de l'étude

Lieux d'étude

Critères de participation

Les chercheurs recherchent des personnes qui correspondent à une certaine description, appelée critères d'éligibilité. Certains exemples de ces critères sont l'état de santé général d'une personne ou des traitements antérieurs.

Critère d'éligibilité

Âges éligibles pour étudier

  • Adulte plus âgé

Accepte les volontaires sains

Non

La description

Inclusion Criteria:

  • Men and women aged 65 years and older
  • Body Mass Index (BMI) between 18.5 and 30 kg/m² (exclusive)
  • Physical activity < 3000 MET-min/week, assessed using the ONAPS-PAQ questionnaire
  • Laboratory tests compatible with participation in the study
  • Adequate venous status, as assessed by study nurses, allowing catheter placement
  • Willingness to participate in study procedures, including indirect calorimetry, functional tests, and assigned dietary intervention (plant-enriched or standard diet)
  • Affiliation with the French Social Security system

Exclusion Criteria:

  • Men and women aged 65 years and older
  • Body Mass Index (BMI) between 18.5 and 30 kg/m² (exclusive)
  • Physical activity < 3000 MET-min/week, assessed using the ONAPS-PAQ questionnaire
  • Laboratory tests compatible with participation in the study
  • Adequate venous status, as assessed by study nurses, allowing catheter placement
  • Willingness to participate in study procedures, including indirect calorimetry, functional tests, and assigned dietary intervention (plant-enriched or standard diet)
  • Affiliation with the French Social Security system
  • Exclusion period from a previous study or total compensation exceeding €6,000 in the 12 months prior to study initiation (verified through the National Research Volunteer Database)
  • Patients under legal guardianship, curatorship, deprived of liberty, or under judicial protection
  • Claustrophobia

Plan d'étude

Cette section fournit des détails sur le plan d'étude, y compris la façon dont l'étude est conçue et ce que l'étude mesure.

Comment l'étude est-elle conçue ?

Détails de conception

  • Objectif principal: La prévention
  • Répartition: Randomisé
  • Modèle interventionnel: Affectation parallèle
  • Masquage: Aucun (étiquette ouverte)

Armes et Interventions

Groupe de participants / Bras
Intervention / Traitement
Comparateur actif: Control diet group
Participants follow a standard diet for older adults with approximately 70% of protein from animal sources and 30% from plant sources. Nutritional guidance and follow-up are provided throughout the 3-month study period. Participants maintain their usual eating habits within these proportions, and dietary compliance is monitored through food diaries and regular consultations with the study team.
Autre: Control diet
Participants follow a standard diet with approximately 70% of protein from animal sources and 30% from plant sources for 3 months, with general nutritional guidance and compliance monitored through food diaries and periodic consultations.
Expérimental: Plant-enriched diet group
Participants follow a diet enriched in plant-based foods, with approximately 70% of protein from plant sources and 30% from animal sources, while maintaining adequate total protein intake. Participants receive tailored dietary guidance and support from the study team over 3 months, including meal planning and regular follow-up. Dietary compliance is assessed using food diaries, recalls, and periodic monitoring by the study team.
Autre: Plant-enriched dietary intervention
Participants follow a diet enriched in plant-based foods with approximately 70% of protein from plant sources and 30% from animal sources for 3 months, with tailored dietary guidance, meal planning support, and compliance monitored through food diaries and periodic follow-up.

Que mesure l'étude ?

Principaux critères de jugement

Mesure des résultats
Description de la mesure
Délai
Maximal Quadriceps Strength
Délai: Baseline and Month 3
Maximal voluntary contraction of the quadriceps muscle will be measured using a standardized dynamometer. This outcome evaluates the primary effect of the dietary intervention on skeletal muscle strength in older adults.
Baseline and Month 3

Mesures de résultats secondaires

Mesure des résultats
Description de la mesure
Délai
Protein metabolism
Délai: Baseline and Month 3
Assessment of plasma amino acid concentrations, ex vivo anabolic response, proteomic and metabolic profiling, and related biomarkers (glucose, insulin, cytokines).
Baseline and Month 3
Short Physical Performance Battery (SPPB) total score
Délai: Baseline and Month 3
Physical performance will be assessed using the Short Physical Performance Battery (SPPB), which combines balance, gait speed, and chair stand performance into a composite score ranging from 0 to 12 points. Higher scores indicate better physical function.
Baseline and Month 3
Handgrip strength
Délai: Baseline and Month 3
Handgrip strength will be measured using a calibrated hand dynamometer. The maximum grip strength will be recorded and reported in kilograms (kg). Higher values indicate greater muscle strength.
Baseline and Month 3
Distance covered during the 6-minute walk test
Délai: Baseline and Month 3
Functional exercise capacity will be assessed using the 6-minute walk test. The total distance walked during 6 minutes will be recorded and reported in meters (m). Higher values indicate better functional capacity.
Baseline and Month 3
Appendicular lean mass
Délai: Baseline and Month 3
Appendicular lean mass will be assessed by dual-energy X-ray absorptiometry (DXA) and reported in kilograms (kg). Higher values indicate greater skeletal muscle mass.
Baseline and Month 3
Relative abundance of dominant gut bacterial taxa
Délai: Baseline and Month 3
Description: Stool samples will be analyzed using microbiome sequencing methods. Relative abundance of predefined dominant bacterial taxa will be quantified and reported as percentages of total bacterial abundance.
Baseline and Month 3
Sex-specific changes in maximal quadriceps strength
Délai: Baseline and Month 3
Quadriceps maximal voluntary contraction force will be measured using a standardized dynamometer and reported in Newtons (N). Changes from baseline will be compared between male and female participants to evaluate sex-specific responses to the dietary intervention.
Baseline and Month 3
Sex-specific changes in serum metabolomic and proteomic profiles
Délai: Baseline and Month 3
Serum metabolomic and proteomic profiles will be analyzed using validated metabolomics and proteomics platforms. Changes in predefined metabolites and proteins will be compared between male and female participants to evaluate sex-specific responses to the dietary intervention.
Baseline and Month 3
Sex-specific changes in appendicular lean mass
Délai: Baseline and Month 3
Appendicular lean mass will be assessed by dual-energy X-ray absorptiometry (DXA) and reported in kilograms (kg). Changes from baseline will be compared between male and female participants to evaluate sex-specific responses to the dietary intervention.
Baseline and Month 3

Collaborateurs et enquêteurs

C'est ici que vous trouverez les personnes et les organisations impliquées dans cette étude.

Parrainer

University Hospital, Clermont-Ferrand

Collaborateurs

Université d'Auvergne
Centre de Recherche en Nutrition Humaine d'Auvergne
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement

Les enquêteurs

  • Chercheur principal: Yves BOIRIE, University Hospital, Clermont-Ferrand

Dates d'enregistrement des études

Ces dates suivent la progression des dossiers d'étude et des soumissions de résultats sommaires à ClinicalTrials.gov. Les dossiers d'étude et les résultats rapportés sont examinés par la Bibliothèque nationale de médecine (NLM) pour s'assurer qu'ils répondent à des normes de contrôle de qualité spécifiques avant d'être publiés sur le site Web public.

Dates principales de l'étude

Début de l'étude (Estimé)

20 juillet 2026

Achèvement primaire (Estimé)

1 août 2029

Achèvement de l'étude (Estimé)

1 août 2030

Dates d'inscription aux études

Première soumission

18 juin 2026

Première soumission répondant aux critères de contrôle qualité

26 juin 2026

Première publication (Réel)

2 juillet 2026

Mises à jour des dossiers d'étude

Dernière mise à jour publiée (Réel)

2 juillet 2026

Dernière mise à jour soumise répondant aux critères de contrôle qualité

26 juin 2026

Dernière vérification

1 mai 2026

Plus d'information

Termes liés à cette étude

Mots clés

Autres numéros d'identification d'étude

  • RBHP 2024 BOIRIE 2
  • 2024-A02027-40 (Autre identifiant: ANSM)

Informations sur les médicaments et les dispositifs, documents d'étude

Étudie un produit pharmaceutique réglementé par la FDA américaine

Non

Étudie un produit d'appareil réglementé par la FDA américaine

Non

Ces informations ont été extraites directement du site Web clinicaltrials.gov sans aucune modification. Si vous avez des demandes de modification, de suppression ou de mise à jour des détails de votre étude, veuillez contacter register@clinicaltrials.gov. Dès qu'un changement est mis en œuvre sur clinicaltrials.gov, il sera également mis à jour automatiquement sur notre site Web .

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