Anhedonia Beyond Depressive Symptoms in Children and Adolescents With Conduct Disorder
Conduct Disorder (CD) is a common psychiatric disorder among children and adolescents and is characterized by a persistent pattern of behaviors that violate the rights of others or major age-appropriate social norms and rules. Although CD is traditionally classified as an externalizing disorder, evidence suggests that some affected adolescents also show abnormalities in emotional and motivational processing, particularly in reward and punishment responsiveness. Anhedonia, defined as reduced ability to experience pleasure, is traditionally considered a core symptom of depression but is increasingly recognized as a transdiagnostic construct that may reflect disturbances in reward processing. Importantly, altered reward responsiveness is not synonymous with clinical anhedonia, and clinically measured anhedonia in adolescents with CD remains insufficiently characterized. Depressive symptoms may contribute to anhedonia and therefore require assessment and statistical control. ADHD is also frequently comorbid with CD and may independently influence reward processing and motivation. Callous-Unemotional traits may additionally overlap with emotional blunting. Therefore, the present study will compare anhedonia in adolescents with CD with or without comorbid ADHD, and healthy controls, while accounting for depressive symptoms and relevant clinical covariates.
Aperçu de l'étude
Statut
Les conditions
Type d'étude
Inscription (Estimé)
Critères de participation
Critère d'éligibilité
Âges éligibles pour étudier
Accepte les volontaires sains
Sexes éligibles pour l'étude
Méthode d'échantillonnage
Population étudiée
Participants aged 12-17 years will be recruited consecutively from the outpatient child and adolescent psychiatry service. Participants meeting criteria for Conduct Disorder will form the clinical group. Healthy controls of comparable age, sex, and socioeconomic status will be recruited from community or school settings. ADHD comorbidity will be assessed within the Conduct Disorder group
La description
Inclusion Criteria:
-
Age 12-17 years.
- CD groups: meeting DSM-5 criteria for Conduct Disorder confirmed using the Arabic K-SADS-PL-C DSM-5.
- Control group: no current or previous psychiatric diagnosis according to the Arabic K-SADS-PL-C DSM-5.
- Ability to understand and complete the assessment procedures.
- Written informed consent from a parent/legal guardian and written assent from the adolescent.
Exclusion Criteria:
-
• Intellectual disability or severe cognitive impairment interfering with reliable assessment.
- Autism spectrum disorder or severe neurodevelopmental disorder interfering with self-report.
- Current psychotic disorder.
- Current or past bipolar I disorder or manic episode.
- Current major depressive episode meeting full diagnostic criteria.
- Current severe substance use disorder.
- Known neurological disorder, including epilepsy or severe traumatic brain injury.
- Major uncontrolled medical condition likely to substantially affect mood or hedonic functioning.
- Current medication expected to substantially affect reward processing or anhedonia, where clinically relevant.
- Acute suicidal risk or psychiatric condition requiring immediate crisis intervention/hospitalization.
- Refusal to participate or inability to complete the assessment. Stable stimulant treatment for ADHD may be permitted when clinically necessary and will be recorded as a covariate.
Plan d'étude
Comment l'étude est-elle conçue ?
Détails de conception
- Modèles d'observation: CASE_CONTROL
- Perspectives temporelles: PROSPECTIVE
Cohortes et interventions
Groupe / Cohorte |
|---|
|
cases group
Participants meeting criteria for Conduct Disorder |
|
control group
healthy control |
Que mesure l'étude ?
Principaux critères de jugement
Mesure des résultats |
Description de la mesure |
Délai |
|---|---|---|
|
SHAPS total score
Délai: baseline
|
SHAPS total score, representing overall anhedonia severity |
baseline
|
Collaborateurs et enquêteurs
Parrainer
Dates d'enregistrement des études
Dates principales de l'étude
Début de l'étude (Estimé)
Achèvement primaire (Estimé)
Achèvement de l'étude (Estimé)
Dates d'inscription aux études
Première soumission
Première soumission répondant aux critères de contrôle qualité
Première publication (Réel)
Mises à jour des dossiers d'étude
Dernière mise à jour publiée (Réel)
Dernière mise à jour soumise répondant aux critères de contrôle qualité
Dernière vérification
Plus d'information
Termes liés à cette étude
Termes MeSH pertinents supplémentaires
Autres numéros d'identification d'étude
- Depression Children&Adolescen
Informations sur les médicaments et les dispositifs, documents d'étude
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