Anhedonia Beyond Depressive Symptoms in Children and Adolescents With Conduct Disorder
Conduct Disorder (CD) is a common psychiatric disorder among children and adolescents and is characterized by a persistent pattern of behaviors that violate the rights of others or major age-appropriate social norms and rules. Although CD is traditionally classified as an externalizing disorder, evidence suggests that some affected adolescents also show abnormalities in emotional and motivational processing, particularly in reward and punishment responsiveness. Anhedonia, defined as reduced ability to experience pleasure, is traditionally considered a core symptom of depression but is increasingly recognized as a transdiagnostic construct that may reflect disturbances in reward processing. Importantly, altered reward responsiveness is not synonymous with clinical anhedonia, and clinically measured anhedonia in adolescents with CD remains insufficiently characterized. Depressive symptoms may contribute to anhedonia and therefore require assessment and statistical control. ADHD is also frequently comorbid with CD and may independently influence reward processing and motivation. Callous-Unemotional traits may additionally overlap with emotional blunting. Therefore, the present study will compare anhedonia in adolescents with CD with or without comorbid ADHD, and healthy controls, while accounting for depressive symptoms and relevant clinical covariates.
Studie Overzicht
Toestand
Conditie
Studietype
Inschrijving (Geschat)
Deelname Criteria
Geschiktheidscriteria
Leeftijden die in aanmerking komen voor studie
Accepteert gezonde vrijwilligers
Geslachten die in aanmerking komen voor studie
Bemonsteringsmethode
Studie Bevolking
Participants aged 12-17 years will be recruited consecutively from the outpatient child and adolescent psychiatry service. Participants meeting criteria for Conduct Disorder will form the clinical group. Healthy controls of comparable age, sex, and socioeconomic status will be recruited from community or school settings. ADHD comorbidity will be assessed within the Conduct Disorder group
Beschrijving
Inclusion Criteria:
-
Age 12-17 years.
- CD groups: meeting DSM-5 criteria for Conduct Disorder confirmed using the Arabic K-SADS-PL-C DSM-5.
- Control group: no current or previous psychiatric diagnosis according to the Arabic K-SADS-PL-C DSM-5.
- Ability to understand and complete the assessment procedures.
- Written informed consent from a parent/legal guardian and written assent from the adolescent.
Exclusion Criteria:
-
• Intellectual disability or severe cognitive impairment interfering with reliable assessment.
- Autism spectrum disorder or severe neurodevelopmental disorder interfering with self-report.
- Current psychotic disorder.
- Current or past bipolar I disorder or manic episode.
- Current major depressive episode meeting full diagnostic criteria.
- Current severe substance use disorder.
- Known neurological disorder, including epilepsy or severe traumatic brain injury.
- Major uncontrolled medical condition likely to substantially affect mood or hedonic functioning.
- Current medication expected to substantially affect reward processing or anhedonia, where clinically relevant.
- Acute suicidal risk or psychiatric condition requiring immediate crisis intervention/hospitalization.
- Refusal to participate or inability to complete the assessment. Stable stimulant treatment for ADHD may be permitted when clinically necessary and will be recorded as a covariate.
Studie plan
Hoe is de studie opgezet?
Ontwerpdetails
- Observatiemodellen: CASE_CONTROL
- Tijdsperspectieven: PROSPECTIVE
Cohorten en interventies
Groep / Cohort |
|---|
|
cases group
Participants meeting criteria for Conduct Disorder |
|
control group
healthy control |
Wat meet het onderzoek?
Primaire uitkomstmaten
Uitkomstmaat |
Maatregel Beschrijving |
Tijdsspanne |
|---|---|---|
|
SHAPS total score
Tijdsspanne: baseline
|
SHAPS total score, representing overall anhedonia severity |
baseline
|
Medewerkers en onderzoekers
Sponsor
Studie record data
Bestudeer belangrijke data
Studie start (Geschat)
Primaire voltooiing (Geschat)
Studie voltooiing (Geschat)
Studieregistratiedata
Eerst ingediend
Eerst ingediend dat voldeed aan de QC-criteria
Eerst geplaatst (Werkelijk)
Updates van studierecords
Laatste update geplaatst (Werkelijk)
Laatste update ingediend die voldeed aan QC-criteria
Laatst geverifieerd
Meer informatie
Termen gerelateerd aan deze studie
Aanvullende relevante MeSH-voorwaarden
Andere studie-ID-nummers
- Depression Children&Adolescen
Informatie over medicijnen en apparaten, studiedocumenten
Bestudeert een door de Amerikaanse FDA gereguleerd geneesmiddel
Bestudeert een door de Amerikaanse FDA gereguleerd apparaatproduct
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