Ravuconazole in Preventing Fungal Infections in Patients Undergoing Allogeneic Stem Cell Transplantation

DISEASE CHARACTERISTICS:

• Undergoing a non-myeloablative allogeneic hematopoietic stem cell transplantation
• Must be able to start prophylactic antifungal therapy within 48 hours of the transplantation chemotherapy preparative regimen and before the initiation of cyclosporine
• No diagnosis of deeply invasive fungal infection based on the MSG/EORTC criteria

PATIENT CHARACTERISTICS:

Age

• 18 and over

Performance status

• ECOG 0-2

Life expectancy

• Not specified

Hematopoietic

• Not specified

Hepatic

• Bilirubin no greater than 5 times upper limit of normal (ULN)
• AST and ALT no greater than 5 times ULN
• Alkaline phosphatase no greater than 5 times ULN

Renal

• Not specified

Other

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective barrier contraception during and for 4 weeks (12 weeks for males) after study participation
• Able to swallow oral medication
• Sufficient venous access
• No prior anaphylaxis attributed to the azole class of antifungals
• No concurrent medical condition that may create an unacceptable additional risk for the patient during study participation

PRIOR CONCURRENT THERAPY:

Biologic therapy

• See Disease Characteristics

Chemotherapy

• Not specified

Endocrine therapy

• No concurrent hormonal contraceptives

Radiotherapy

• Not specified

Surgery

• Not specified

Other

• At least 2 weeks since other prior non-FDA approved investigational drugs
• No concurrent QTc prolonging medication (e.g., terfenadine, cisapride, quinidine, pimozide, or dofetilide)
• No concurrent rifampin
• No other concurrent experimental or systemic antifungal therapy
• No concurrent agents containing amphotericin B
• No other concurrent systemic azole or triazole antifungal agents
• No concurrent echinocandins
• Concurrent topical antifungals allowed