Cohort Study: Perceptual Urge Sensation
Over the past few years it has become clear that our understanding of bladder physiology is inadequate to explain urge incontinence. This has forced us to re-evaluate what we know and do not know about bladder function and dysfunction. This has led to the identification and study of novel systems within the bladder that may contribute to abnormal sensations.
The investigators now suspect that the organic changes occurring in the bladder are not the whole story. For one group of patients with pathological urge there is growing evidence suggesting that there may be a strong psychological component. The idea now being put forward is that normal afferent peripheral information is perceived as abnormal and excessive, resulting in an increased desire to go to the bathroom: 'perceptual urge'. It is important to identify this group of patients since it will direct their treatment towards more cognitive approaches. Also, if such a psychological aetiology can be eliminated it would lead to a more focused and effective management of peripheral pathology with surgery or pharmacology.
調査の概要
状態
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Limburg
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Maastricht、Limburg、オランダ、6202 AZ
- Maastricht University Medical Centre
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
The study population consists of two groups: 1: patients with OAB; 2: patients with osteoporosis.
The patients with OAB will be reqruited from the outpatient clinic and website designed for patients with overactive bladder symptoms.
The patients with osteoporosis will be recruited from an electronic patient database.
説明
Inclusion Criteria (for patients with OAB):
- Patients older than 18 years with OAB diagnosed by their urologist using the criteria of more than 8 micturitions on three consecutive days of these three days they keep a micturation diary with a VAS score for urge sensation.
Patients should have at least one episode of urge: sudden compelling desire to void which can not be postponed.
- Well versed in Dutch.
Inclusion Criteria (for patients with osteoporosis):
- Patients older than 18 years with osteoporosis joined into the Fast Guide cohort program.
- Well versed in Dutch.
Exclusion Criteria (for patients with OAB):
- Patients with stress-urinary incontinence
- Presence of post void residual urine > 100cc determined by ultrasound
- Presence of urinary tract infection, determined by urine sticks. Patients with urinary tract infection will be treated by antibiotics. After resolution of the infection, the patient can re-enter the study if the urine is sterile at that moment.
Exclusion Criteria (for patients with osteoporosis):
- Urinary complaints or urologic history
- Presence of postvoid residual urine > 100cc determined by ultrasound
- Presence of urinary tract infection, determined by urine sticks. Patients that present with urinary tract infection will be definitively excluded from participation.
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
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OAB
Patients with overactive bladder syndrome
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On the micturition diary patients are asked to note every void and drink.
With every void they are asked to estimate their bladder volume and grade their degree of desire to void.
This questionnaire is designed to screen for the presence of a mood disorder.
This questionnaire grades the health condition of the subject.
The questions tap cognitive, emotional, and physical appearance aspects of directing their attention to the self.
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Osteoporosis
Patients with osteoporosis
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On the micturition diary patients are asked to note every void and drink.
With every void they are asked to estimate their bladder volume and grade their degree of desire to void.
This questionnaire is designed to screen for the presence of a mood disorder.
This questionnaire grades the health condition of the subject.
The questions tap cognitive, emotional, and physical appearance aspects of directing their attention to the self.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
|
Defining differences in self-consciousness and HADS scores in patients with OAB
時間枠：1 year
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1 year
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二次結果の測定
結果測定 |
時間枠 |
|---|---|
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Defining differences between self-consciousness and HADS scores between the two cohorts
時間枠：1 year
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1 year
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Defining differences in quality of life between the two cohorts
時間枠：1 year
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1 year
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協力者と研究者
捜査官
- スタディディレクター：Gommert van Koeveringe, MD, PhD, urologist、Maastricht University Medical Centre
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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