Coupling of Neural Activity and Retinal Blood Flow in Diabetes
The prevalence of diabetes is increasing and the management of the disease is nowadays considered a major challenge. Affected patients have increased mortality and morbidity as well as a significant drop in the quality of life. The complications of diabetes can be classified as microvascular (e.g. nephropathy, neuropathy or retinopathy) or macrovascular (e.g. cardiovascular or cerebrovascular).
Several large-scale epidemiologic studies indicating that wider retinal venous caliber is strongly associated with the fasting glucose level as well as with diabetes. Another retinal vascular abnormality that is associated with diabetes is an abnormal retinal vascular response to flicker stimulation. Retinal vessel dilatation in response to stimulation with diffuse flicker light occurs due to a phenomenon called neurovascular coupling. This means that increased activity of neurons is associated with an increased retinal metabolism. This leads to a release of endogenous vasodilator substances and increased blood flow. However, previous studies were limited by the fact that retinal vessel diameters and blood flow were not measured simultaneously.
The present study aims to investigate whether the response of retinal vessel diameters and blood flow velocities to flicker stimulation is altered in patients with diabetes. Both parameters will be measured in real time using Fourier Domain Doppler OCT.
調査の概要
状態
条件
研究の種類
入学 (実際)
連絡先と場所
研究場所
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Vienna、オーストリア、1090
- Department of Clinical Pharmacology
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
説明
Inclusion Criteria:
- Men and women aged over 18 years, nonsmokers
- Normal findings in the medical history (except diabetes) and physical examination unless the investigator considers an abnormality to be clinically irrelevant
- normal laboratory findings (except diabetes associated parameters) unless the investigator considers the abnormality to be clinically irrelevant
- normal ophthalmic findings (except mild diabetic retinopathy), Ametropia less than 6 diopters
- inclusion criterion of patients is type I diabetes with non or mild non-proliferative retinopathy
Exclusion criteria
Any of the following will exclude a healthy subject from the study:
- Regular use of vasoactive drugs
- Abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- Blood donation during the previous 3 weeks
- History or presence of any ocular pathology
- History or family history of epilepsy
- Systemic hypertension defined as systolic blood pressure >150mmHg, diastolic blood pressure >90mmHg
- Pregnancy
Any of the following will exclude a subject with diabetes from the study:
- Presence of non-insulin dependent diabetes, maturity onset diabetes of the young (MODY diabetes)
- History or presence of any other diabetes induced vascular pathologies or any other ocular condition other then diabetic retinopathy
- Best corrected visual acuity <0.8
- Previous laser photocoagulation treatment
- Systemic hypertension defined as systolic blood pressure >150mmHg, diastolic blood pressure >90mmHg
- History or family history of epilepsy
- Abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
- Symptoms of a clinically relevant illness in the 3 weeks before the first study day
- Blood donation during the previous 3 weeks
- Pregnancy
研究計画
研究はどのように設計されていますか？
デザインの詳細
コホートと介入
グループ/コホート |
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Diabetic retinopathy
Patients with early insulin dependent diabetes and no or mild non-proliferative retinopathy
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healthy
healthy control subjects
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
時間枠 |
|---|---|
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Retinal vessel diameters
時間枠：18 months
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18 months
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Retinal blood flow velocities
時間枠：18 months
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18 months
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協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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