Particle Sizing of Masticated Tree Nuts - Pistachios and Brazils
The investigators want to understand how oral processing (chewing) of nuts affects particle size and the presence of lipid (fat) on the cut surfaces.
The main objective of the study is to:
Measure the size of nut particles that have been chewed sufficiently to be swallowed.
The secondary objective of this study is to:
Measure any changes in lipid content due to chewing and compare it to a prediction from a theoretical model.
The investigators have developed a theoretical model for determining the release of nutrients from plant foods, specifically lipid (fat) from almonds. The model has been used to calculate the amount of lipid released from chewed almonds. The model shows that only about 10% of the lipid is immediately released. The investigators require information on the particle size distribution (number of particles of each size) for other chewed nuts to calculate the amount of lipid released for other nuts. This will allow us to check the validity of our model for other foods.
調査の概要
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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London、イギリス、SE1 9NH
- Diabetes and Nutritional Sciences Division, School of Medicine, King's College London
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Must be generally healthy
- Must have eaten nuts within the last month with no adverse effects
Exclusion Criteria:
- Must not be allergic to nuts of any kind
- Must not have any teeth missing (apart from unerupted wisdom teeth)
- Must not have bleeding gums
- Must not have had dental treatment (other than checkups) in the last 3 months
- Must not be currently suffering from any infectious disease that may be passed on via saliva e.g. Glandular fever, flu
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Chewing of nuts
8 samples (4-5 g) of nuts (pistachios or Brazils) on two separate visit days.
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The volunteers will be asked to chew and spit 8 portions (4-5 g) of nuts (pistachios or Brazils) on two separate visits.
They will provide samples for particle sizing.
Two portions will be used as practice samples in order to measure the number of chews.
Two portions will be sieved.
Two portions will be measured by laser diffraction.
Two portions will be frozen for later lipid analysis.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Particle size distribution of masticated nuts
時間枠：At time of expectoration, up to 90 seconds after each sample ingested
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Particle size distribution of masticated nuts as measured by laser diffraction and sieving.
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At time of expectoration, up to 90 seconds after each sample ingested
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Lipid content of masticated nuts
時間枠：At time of expectoration, up to 90 seconds after each sample ingested.
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Lipid content of masticated nuts as measured by Soxhlet to be compared to predictions form mathematical model.
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At time of expectoration, up to 90 seconds after each sample ingested.
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Sarah EE Berry, BSc MSc PhD、King's College London
出版物と役立つリンク
一般刊行物
- Grundy MM, Grassby T, Mandalari G, Waldron KW, Butterworth PJ, Berry SE, Ellis PR. Effect of mastication on lipid bioaccessibility of almonds in a randomized human study and its implications for digestion kinetics, metabolizable energy, and postprandial lipemia. Am J Clin Nutr. 2015 Jan;101(1):25-33. doi: 10.3945/ajcn.114.088328. Epub 2014 Nov 12.
- Grassby T, Picout DR, Mandalari G, Faulks RM, Kendall CW, Rich GT, Wickham MS, Lapsley K, Ellis PR. Modelling of nutrient bioaccessibility in almond seeds based on the fracture properties of their cell walls. Food Funct. 2014 Dec;5(12):3096-106. doi: 10.1039/c4fo00659c.
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (予想される)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (見積もり)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
この情報は、Web サイト clinicaltrials.gov から変更なしで直接取得したものです。研究の詳細を変更、削除、または更新するリクエストがある場合は、register@clinicaltrials.gov。 までご連絡ください。 clinicaltrials.gov に変更が加えられるとすぐに、ウェブサイトでも自動的に更新されます。