Infra-slow Oscillations During Sleep (SleepD-ISO)
Infra-slow Oscillations During Sleep, After Acute Sleep Deprivation and in Subjects With Restless Legs Syndrome/Periodic Leg Movements During Sleep (RLS/PLMS): an Explorative, Prospective, Monocentric, Observational Case-control and Interventional Study
調査の概要
詳細な説明
Sleep is a highly dynamic process and during large parts of sleep the level of arousal fluctuates on a multi-second time scale between the sleep stage specific background and transient, phasic events that clearly arise from this background and constitute the microstructure of sleep. This microstructure is part of the dynamic physiological sleep regulation and at the same time reflects the instability of sleep, is critically involved in the pathophysiology of sleep and a determinant of the recuperative value of sleep and daytime performance.
Intriguingly, these sleep microstructural fluctuations are in a multi-second range that corresponds closely to the so-called infra-slow oscillations that are ubiquitous in the central nervous system. Infra-slow oscillations (0.01 - 0.1 Hz) have been observed in both humans and animals across brain structures and spatial scales in the dynamics of single unit firing rates, direct electrical potential fluctuations and oscillation amplitude modulations. The possibility to record these infra-slow oscillations on the level of the surface EEG with direct current (DC) or Full band (Fb) EEG offers a new approach to study the microstructure of sleep and characterise the full range of sleep-related EEG oscillations.
The objectives of this study are:
- to record and systematically characterise infra-slow oscillations during wake and all stages of sleep
- to explore the relationship between sleep infra-slow oscillations and microstructural events of sleep, in particular the cyclic alternating pattern
- to explore the effect of acute sleep deprivation on sleep infra-slow EEG activity
- to investigate infra-slow sleep EEG activity in patients with RLS/PLMS, common sleep disorders with prominent periodic arousals, heart rate activations, and leg movements
- to explore the relationship between infra-slow EEG oscillations and periodic events in movement and autonomic system activity in patients with RLS/PLMS.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Ticino
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Lugano、Ticino、スイス、6903
- Neurocenter of Southern Switzerland
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria for all participants:
- Willingness to participate and written informed consent
- Aged 20 to 40 years at the time of screening
- Body mass index (BMI) ≤ 30
Additional inclusion criteria for subjects with RLS/PLMS:
- Either diagnosis of RLS and current IRLS score ≥ 15.
- Or frequent periodic leg movements during sleep
Exclusion criteria for all participants:
- Pregnancy or breast feeding at the time of screening
- Sleep related breathing disorders
- Current psychiatric disorders
- Current chronic treatment that may affect sleep.
- Any significant neurological disorder or other medical disease that may affect sleep.
- Any unstable medical condition.
Additional exclusion criteria for participants with RLS/PLMS:
- Current intake of dopaminergic drugs
- Current intake of other RLS relevant medication
- Intake of hypnotics
- Other significant sleep disorder except symptoms potentially related to RLS
Additional exclusion criteria for healthy participants:
- Any pharmacological treatment that may affect sleep and/or sleep related movement disorders
- Any clinically significant sleep disorders
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：Acute sleep deprivation
Registration of habitual sleep and sleep after sleep deprivation
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Participants will stay awake for 36 hours
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Infra-slow frequency power
時間枠：36 hours
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Average power (µV) in the infra-slow frequency range during wake and different stages of sleep derived from standard fast fourier transform and continuous wavelet transform.
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36 hours
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協力者と研究者
スポンサー
捜査官
- 主任研究者：Stephany Fulda, PhD、Neurocenter of Southern Switzerland
研究記録日
主要日程の研究
研究開始
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (見積もり)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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