Regulation of Craving in Internet Gamers
2018年12月17日 更新者：jintao, zhang、Beijing Normal University
Regulation of Craving in Internet Gamers: Neural Mechanisms and tDCS Intervention
This project aims to investigate (1) the behavioral and neural mechanisms of regulation of craving in Internet gamers; (2) effects of tDCS over the dorsal lateral prefrontal cortex (dlPFC) on craving and regulation of craving and aversive emotions in this population.
(3) effects of tDCS over dlPFC on attentional bias towards gaming related cues.This project will be conducted in Beijing, China, based on a large sample of Internet gamers.
調査の概要
詳細な説明
As with the experiment about tDCS effects on regulation of craving and aversive emotions, the experiment aims to test whether tDCS over dlPFC will enhance cognitive regulation of craving and aversive emotions. It is a within-subject, sham-controlled, double-blind design. Each participant receive both active and sham tDCS of dlPFC in a randomized order separated by one week. During both active and sham tDCS sessions, participants will perform regulation of craving (ROC) and emotion regulation (ER) tasks. In the ROC task, participants will be asked to downregulate and upregulate craving elicited by gaming pictures using cognitive reappraisal. In the ER task, participants will be asked to downregulate and upregulate aversive feelings elicited by negative pictures using cognitive reappraisal. During these tasks, self-report ratings and skin conductance responses (SCRs) will be recorded. The cognitive regulation ability is indexed by rating and SCRs differences between the up- and downregulation conditions.
As with the experiment about tDCS effects on attentional bias, the experiment aims to test whether tDCS over dlPFC will enhance inhibitory control of attentional bias towards gaming related cues. The inhibitory control of attentional bias will be measured by a cognitive task in which participants will perform a number classification task with gaming pictures and non-gaming pictures being distractors. The experiment is a within-subject, sham-controlled, double-blind design. Each participant will receive both active and sham tDCS of dlPFC in a randomized order separated by one week. After each tDCS session, participants will complete the cognitive task assessing inhibitory control of attentional bias. During the task, reaction times (RTs) wil be recorded. The attentional bias is indexed by RTs differences between trials with gaming pictures and trials with non-gaming pictures.
研究の種類
介入
入学 (実際)
20
段階
- 適用できない
連絡先と場所
このセクションには、調査を実施する担当者の連絡先の詳細と、この調査が実施されている場所に関する情報が記載されています。
研究場所
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Beijing
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Beijing、Beijing、中国、100875
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University
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参加基準
研究者は、適格基準と呼ばれる特定の説明に適合する人を探します。これらの基準のいくつかの例は、人の一般的な健康状態または以前の治療です。
適格基準
就学可能な年齢
18年～30年 (大人)
健康ボランティアの受け入れ
はい
受講資格のある性別
全て
説明
Inclusion Criteria:
- engagement in a popular Internet game (Arena of Valor) for over 14 hours per week for a minimum of 6 months.
Exclusion Criteria:
- current or history of use of illegal substances and gambling;
- current or history of psychiatric or neurological illness;
- current use of psychotropic medications.
研究計画
このセクションでは、研究がどのように設計され、研究が何を測定しているかなど、研究計画の詳細を提供します。
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：基礎科学
- 割り当て：ランダム化
- 介入モデル：クロスオーバー割り当て
- マスキング：ダブル
武器と介入
参加者グループ / アーム |
介入・治療 |
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実験的：active tDCS on the dlPFC
tDCS on the DLPFC Dorsolateral prefrontal cortex (DLPFC) target will be identified by the baseline functional magnetic resonance imaging (fMRI) study for regulation of craving using a separate sample.
During the intervention, each participant will receive an active transcranial direct current stimulation (tDCS) intervention on this DLPFC region (1.5 mA for 20 minutes).
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During active tDCS session, participants will perform the regulation of craving (ROC) and emotion regulation (ER) tasks.
In the ROC task, participants will downregulate and upregulate craving elicited by gaming pictures using cognitive reappraisal.
In the ER task, participants will downregulate and upregulate aversive feelings by negative pictures using cognitive reappraisal.
After the active tDCS session, participants will complete a cognitive task assessing inhibitory control of attentional bias, in which participants will perform a number classification task with gaming pictures and non-gaming pictures being distractors.
During the task, reaction times (RTs) wil be recorded.
他の名前：
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偽コンパレータ：sham tDCS on the dlPFC
Each participant will also receive a sham tDCS intervention as a controlled condition.
The sham tDCS only include a 30-s ramp up and a 30-s ramp down.
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During the sham tDCS session, participants will perform the regulation of craving (ROC) and emotion regulation (ER) tasks.
In the ROC task, participants will downregulate and upregulate craving elicited by gaming pictures using cognitive reappraisal.
In the ER task, participants will downregulate and upregulate aversive feelings by negative pictures using cognitive reappraisal.
After the sham tDCS session, participants will complete a cognitive task assessing inhibitory control of attentional bias, in which participants will perform a number classification task with gaming pictures and non-gaming pictures being distractors.
During the task, reaction times (RTs) wil be recorded.
他の名前：
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Craving in the regulation of craving (ROC) task after the initiation of active and sham tDCS
時間枠：4 minutes after the initiation of active and sham tDCS for half of the participants
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), craving is assessed in the ROC task.
This task lasts 12-13 minutes.
Craving in the downregulation condition will be compared between the active and sham tDCS.
Craving in the upregulation condition will also be compared between the active and sham tDCS.
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4 minutes after the initiation of active and sham tDCS for half of the participants
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Aversive feeling in the emotion regulation (ER) task after the initiation of active and sham tDCS
時間枠：16-17 minutes after the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), aversive feeling is assessed in the ER task.
This task lasts 12-13 minutes.
Aversive feeling in the downregulation condition will be compared between the active and sham tDCS.
Aversive feeling in the upregulation condition will also be compared between the active and sham tDCS.
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16-17 minutes after the initiation of active and sham tDCS
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Reaction times (RTs) in the cognitive task assessing inhibition of attentional bias after the initiation of active and sham tDCS
時間枠：45-47 minutes after the initiation of of active and sham tDCS
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Using the E-prime software, RTs are recorded in milliseconds in the cognitive task assessing inhibition of attentional bias.
The cognitive task lasts 5-6 minutes.
RTs difference between the trials including gaming pictures and those including gaming pictures will be calculated and such RTs difference will be compared between the active and sham tDCS.
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45-47 minutes after the initiation of of active and sham tDCS
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Skin conductance responses (SCRs) in the ROC task after the initiation of active and sham tDCS
時間枠：4 minutes after the initiation of active and sham tDCS
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Using a biosignal recorder, SCRs are recorded in μs in the ROC task.
This task lasts 12-13 minutes.
SCRs in the downregulation condition will be compared between the active and sham tDCS.
SCRs in the upregulation condition will also be compared between the active and sham tDCS.
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4 minutes after the initiation of active and sham tDCS
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Skin conductance responses (SCRs) in the ER task after the initiation of active and sham tDCS
時間枠：16-17 minutes after the initiation of active and sham tDCS ham tDCS
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Using a biosignal recorder, SCRs are recorded in μs in the ER task.
This task lasts 12-13 minutes.
SCRs in the downregulation condition will be compared between the active and sham tDCS.
SCRs in the upregulation condition will also be compared between the active and sham tDCS.
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16-17 minutes after the initiation of active and sham tDCS ham tDCS
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Background craving before the initiation of active and sham tDCS
時間枠：Approximately 10 minutes before the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), background craving is assessed with a one-item questionaire (how much do you crave playing internet games now?).
This assessment lasts approximately 1 minute.
Background craving will be compared between the active and sham tDCS.
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Approximately 10 minutes before the initiation of active and sham tDCS
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Cue-induced craving before the initiation of active and sham tDCS
時間枠：Approximately 8 minutes before the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), cue-induced craving is assessed in a cue-reactivity task.
This assessment lasts 1-2 minutes.
Cue-induced craving will be compared between the active and sham tDCS.
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Approximately 8 minutes before the initiation of active and sham tDCS
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Background craving after the initiation of active and sham tDCS
時間枠：38-40 minutes after the the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), background craving is assessed with a one-item questionaire (how much do you crave playing internet games now?).
This assessment lasts approximately 1 minute.
Background craving will be compared between the active and sham tDCS.
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38-40 minutes after the the initiation of active and sham tDCS
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Cue-induced craving after the initiation of active and sham tDCS
時間枠：40-42 minutes after the the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), cue-induced craving is assessed in a cue-reactivity task.
This assessment lasts 1-2 minutes.
Cue-induced craving will be compared between the active and sham tDCS.
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40-42 minutes after the the initiation of active and sham tDCS
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協力者と研究者
ここでは、この調査に関係する人々や組織を見つけることができます。
捜査官
- 主任研究者：Jin-Tao Zhang, Phd、Beijing Normal University
出版物と役立つリンク
研究に関する情報を入力する責任者は、自発的にこれらの出版物を提供します。これらは、研究に関連するあらゆるものに関するものである可能性があります。
一般刊行物
- Kober H, Mende-Siedlecki P, Kross EF, Weber J, Mischel W, Hart CL, Ochsner KN. Prefrontal-striatal pathway underlies cognitive regulation of craving. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14811-6. doi: 10.1073/pnas.1007779107. Epub 2010 Aug 2.
- Wu LL, Potenza MN, Zhou N, Kober H, Shi XH, Yip SW, Xu JH, Zhu L, Wang R, Liu GQ, Zhang JT. Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder. J Psychiatry Neurosci. 2021 Jan 4;46(1):E111-E118. doi: 10.1503/jpn.190137.
研究記録日
これらの日付は、ClinicalTrials.gov への研究記録と要約結果の提出の進捗状況を追跡します。研究記録と報告された結果は、国立医学図書館 (NLM) によって審査され、公開 Web サイトに掲載される前に、特定の品質管理基準を満たしていることが確認されます。
主要日程の研究
研究開始 (実際)
2018年7月20日
一次修了 (実際)
2018年9月15日
研究の完了 (実際)
2018年10月20日
試験登録日
最初に提出
2017年11月13日
QC基準を満たした最初の提出物
2017年11月20日
最初の投稿 (実際)
2017年11月24日
学習記録の更新
投稿された最後の更新 (実際)
2018年12月19日
QC基準を満たした最後の更新が送信されました
2018年12月17日
最終確認日
2018年12月1日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- IGDROC
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