Regulation of Craving in Internet Gamers
2018년 12월 17일 업데이트: jintao, zhang, Beijing Normal University
Regulation of Craving in Internet Gamers: Neural Mechanisms and tDCS Intervention
This project aims to investigate (1) the behavioral and neural mechanisms of regulation of craving in Internet gamers; (2) effects of tDCS over the dorsal lateral prefrontal cortex (dlPFC) on craving and regulation of craving and aversive emotions in this population.
(3) effects of tDCS over dlPFC on attentional bias towards gaming related cues.This project will be conducted in Beijing, China, based on a large sample of Internet gamers.
연구 개요
상세 설명
As with the experiment about tDCS effects on regulation of craving and aversive emotions, the experiment aims to test whether tDCS over dlPFC will enhance cognitive regulation of craving and aversive emotions. It is a within-subject, sham-controlled, double-blind design. Each participant receive both active and sham tDCS of dlPFC in a randomized order separated by one week. During both active and sham tDCS sessions, participants will perform regulation of craving (ROC) and emotion regulation (ER) tasks. In the ROC task, participants will be asked to downregulate and upregulate craving elicited by gaming pictures using cognitive reappraisal. In the ER task, participants will be asked to downregulate and upregulate aversive feelings elicited by negative pictures using cognitive reappraisal. During these tasks, self-report ratings and skin conductance responses (SCRs) will be recorded. The cognitive regulation ability is indexed by rating and SCRs differences between the up- and downregulation conditions.
As with the experiment about tDCS effects on attentional bias, the experiment aims to test whether tDCS over dlPFC will enhance inhibitory control of attentional bias towards gaming related cues. The inhibitory control of attentional bias will be measured by a cognitive task in which participants will perform a number classification task with gaming pictures and non-gaming pictures being distractors. The experiment is a within-subject, sham-controlled, double-blind design. Each participant will receive both active and sham tDCS of dlPFC in a randomized order separated by one week. After each tDCS session, participants will complete the cognitive task assessing inhibitory control of attentional bias. During the task, reaction times (RTs) wil be recorded. The attentional bias is indexed by RTs differences between trials with gaming pictures and trials with non-gaming pictures.
연구 유형
중재적
등록 (실제)
20
단계
- 해당 없음
연락처 및 위치
이 섹션에서는 연구를 수행하는 사람들의 연락처 정보와 이 연구가 수행되는 장소에 대한 정보를 제공합니다.
연구 장소
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Beijing
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Beijing, Beijing, 중국, 100875
- State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University
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참여기준
연구원은 적격성 기준이라는 특정 설명에 맞는 사람을 찾습니다. 이러한 기준의 몇 가지 예는 개인의 일반적인 건강 상태 또는 이전 치료입니다.
자격 기준
공부할 수 있는 나이
18년 (성인)
건강한 자원 봉사자를 받아들입니다
예
연구 대상 성별
모두
설명
Inclusion Criteria:
- engagement in a popular Internet game (Arena of Valor) for over 14 hours per week for a minimum of 6 months.
Exclusion Criteria:
- current or history of use of illegal substances and gambling;
- current or history of psychiatric or neurological illness;
- current use of psychotropic medications.
공부 계획
이 섹션에서는 연구 설계 방법과 연구가 측정하는 내용을 포함하여 연구 계획에 대한 세부 정보를 제공합니다.
연구는 어떻게 설계됩니까?
디자인 세부사항
- 주 목적: 기초 과학
- 할당: 무작위
- 중재 모델: 크로스오버 할당
- 마스킹: 더블
무기와 개입
참가자 그룹 / 팔 |
개입 / 치료 |
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실험적: active tDCS on the dlPFC
tDCS on the DLPFC Dorsolateral prefrontal cortex (DLPFC) target will be identified by the baseline functional magnetic resonance imaging (fMRI) study for regulation of craving using a separate sample.
During the intervention, each participant will receive an active transcranial direct current stimulation (tDCS) intervention on this DLPFC region (1.5 mA for 20 minutes).
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During active tDCS session, participants will perform the regulation of craving (ROC) and emotion regulation (ER) tasks.
In the ROC task, participants will downregulate and upregulate craving elicited by gaming pictures using cognitive reappraisal.
In the ER task, participants will downregulate and upregulate aversive feelings by negative pictures using cognitive reappraisal.
After the active tDCS session, participants will complete a cognitive task assessing inhibitory control of attentional bias, in which participants will perform a number classification task with gaming pictures and non-gaming pictures being distractors.
During the task, reaction times (RTs) wil be recorded.
다른 이름들:
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가짜 비교기: sham tDCS on the dlPFC
Each participant will also receive a sham tDCS intervention as a controlled condition.
The sham tDCS only include a 30-s ramp up and a 30-s ramp down.
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During the sham tDCS session, participants will perform the regulation of craving (ROC) and emotion regulation (ER) tasks.
In the ROC task, participants will downregulate and upregulate craving elicited by gaming pictures using cognitive reappraisal.
In the ER task, participants will downregulate and upregulate aversive feelings by negative pictures using cognitive reappraisal.
After the sham tDCS session, participants will complete a cognitive task assessing inhibitory control of attentional bias, in which participants will perform a number classification task with gaming pictures and non-gaming pictures being distractors.
During the task, reaction times (RTs) wil be recorded.
다른 이름들:
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연구는 무엇을 측정합니까?
주요 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Craving in the regulation of craving (ROC) task after the initiation of active and sham tDCS
기간: 4 minutes after the initiation of active and sham tDCS for half of the participants
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), craving is assessed in the ROC task.
This task lasts 12-13 minutes.
Craving in the downregulation condition will be compared between the active and sham tDCS.
Craving in the upregulation condition will also be compared between the active and sham tDCS.
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4 minutes after the initiation of active and sham tDCS for half of the participants
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Aversive feeling in the emotion regulation (ER) task after the initiation of active and sham tDCS
기간: 16-17 minutes after the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), aversive feeling is assessed in the ER task.
This task lasts 12-13 minutes.
Aversive feeling in the downregulation condition will be compared between the active and sham tDCS.
Aversive feeling in the upregulation condition will also be compared between the active and sham tDCS.
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16-17 minutes after the initiation of active and sham tDCS
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Reaction times (RTs) in the cognitive task assessing inhibition of attentional bias after the initiation of active and sham tDCS
기간: 45-47 minutes after the initiation of of active and sham tDCS
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Using the E-prime software, RTs are recorded in milliseconds in the cognitive task assessing inhibition of attentional bias.
The cognitive task lasts 5-6 minutes.
RTs difference between the trials including gaming pictures and those including gaming pictures will be calculated and such RTs difference will be compared between the active and sham tDCS.
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45-47 minutes after the initiation of of active and sham tDCS
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2차 결과 측정
결과 측정 |
측정값 설명 |
기간 |
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Skin conductance responses (SCRs) in the ROC task after the initiation of active and sham tDCS
기간: 4 minutes after the initiation of active and sham tDCS
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Using a biosignal recorder, SCRs are recorded in μs in the ROC task.
This task lasts 12-13 minutes.
SCRs in the downregulation condition will be compared between the active and sham tDCS.
SCRs in the upregulation condition will also be compared between the active and sham tDCS.
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4 minutes after the initiation of active and sham tDCS
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Skin conductance responses (SCRs) in the ER task after the initiation of active and sham tDCS
기간: 16-17 minutes after the initiation of active and sham tDCS ham tDCS
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Using a biosignal recorder, SCRs are recorded in μs in the ER task.
This task lasts 12-13 minutes.
SCRs in the downregulation condition will be compared between the active and sham tDCS.
SCRs in the upregulation condition will also be compared between the active and sham tDCS.
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16-17 minutes after the initiation of active and sham tDCS ham tDCS
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Background craving before the initiation of active and sham tDCS
기간: Approximately 10 minutes before the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), background craving is assessed with a one-item questionaire (how much do you crave playing internet games now?).
This assessment lasts approximately 1 minute.
Background craving will be compared between the active and sham tDCS.
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Approximately 10 minutes before the initiation of active and sham tDCS
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Cue-induced craving before the initiation of active and sham tDCS
기간: Approximately 8 minutes before the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), cue-induced craving is assessed in a cue-reactivity task.
This assessment lasts 1-2 minutes.
Cue-induced craving will be compared between the active and sham tDCS.
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Approximately 8 minutes before the initiation of active and sham tDCS
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Background craving after the initiation of active and sham tDCS
기간: 38-40 minutes after the the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), background craving is assessed with a one-item questionaire (how much do you crave playing internet games now?).
This assessment lasts approximately 1 minute.
Background craving will be compared between the active and sham tDCS.
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38-40 minutes after the the initiation of active and sham tDCS
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Cue-induced craving after the initiation of active and sham tDCS
기간: 40-42 minutes after the the initiation of active and sham tDCS
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Using the Visual Analog Scale (from 1 = 'not at all' to 9 = 'very much'), cue-induced craving is assessed in a cue-reactivity task.
This assessment lasts 1-2 minutes.
Cue-induced craving will be compared between the active and sham tDCS.
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40-42 minutes after the the initiation of active and sham tDCS
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공동 작업자 및 조사자
여기에서 이 연구와 관련된 사람과 조직을 찾을 수 있습니다.
수사관
- 수석 연구원: Jin-Tao Zhang, PhD, Beijing Normal University
간행물 및 유용한 링크
연구에 대한 정보 입력을 담당하는 사람이 자발적으로 이러한 간행물을 제공합니다. 이것은 연구와 관련된 모든 것에 관한 것일 수 있습니다.
일반 간행물
- Kober H, Mende-Siedlecki P, Kross EF, Weber J, Mischel W, Hart CL, Ochsner KN. Prefrontal-striatal pathway underlies cognitive regulation of craving. Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14811-6. doi: 10.1073/pnas.1007779107. Epub 2010 Aug 2.
- Wu LL, Potenza MN, Zhou N, Kober H, Shi XH, Yip SW, Xu JH, Zhu L, Wang R, Liu GQ, Zhang JT. Efficacy of single-session transcranial direct current stimulation on addiction-related inhibitory control and craving: a randomized trial in males with Internet gaming disorder. J Psychiatry Neurosci. 2021 Jan 4;46(1):E111-E118. doi: 10.1503/jpn.190137.
연구 기록 날짜
이 날짜는 ClinicalTrials.gov에 대한 연구 기록 및 요약 결과 제출의 진행 상황을 추적합니다. 연구 기록 및 보고된 결과는 공개 웹사이트에 게시되기 전에 특정 품질 관리 기준을 충족하는지 확인하기 위해 국립 의학 도서관(NLM)에서 검토합니다.
연구 주요 날짜
연구 시작 (실제)
2018년 7월 20일
기본 완료 (실제)
2018년 9월 15일
연구 완료 (실제)
2018년 10월 20일
연구 등록 날짜
최초 제출
2017년 11월 13일
QC 기준을 충족하는 최초 제출
2017년 11월 20일
처음 게시됨 (실제)
2017년 11월 24일
연구 기록 업데이트
마지막 업데이트 게시됨 (실제)
2018년 12월 19일
QC 기준을 충족하는 마지막 업데이트 제출
2018년 12월 17일
마지막으로 확인됨
2018년 12월 1일
추가 정보
이 정보는 변경 없이 clinicaltrials.gov 웹사이트에서 직접 가져온 것입니다. 귀하의 연구 세부 정보를 변경, 제거 또는 업데이트하도록 요청하는 경우 register@clinicaltrials.gov. 문의하십시오. 변경 사항이 clinicaltrials.gov에 구현되는 즉시 저희 웹사이트에도 자동으로 업데이트됩니다. .
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