Minipooled-IVIG in Primary Immunodeficiency Disease
Study of Safety and Efficacy of Mini-pool Intravenous Immunoglobulin (MP-IVIG) Prepared by Assiut University Hospital Blood Bank in Primary Immunodeficiency Patients
- study the pharmacokinetics of mini-pooled intravenous immunoglobulin( MP-IVIG)
Study the safety and efficacy of a newly developed preparation of MP-IVIG in children with primary immunodeficiency (PID) :
- Adverse reaction of MP-IVIG(anaphylaxis and haemolysis)( no or mild or moderate)
- Prevention of severe bacterial infection
- Improvement of general health(weight gain and mentality)
- Integration in to social live
- Compare the efficacy of MP-IVIG to standard IVIG in children with primary immunodeficiency (PID).
調査の概要
詳細な説明
Primary immunodeficiency diseases (PID) are a heterogeneous group of inherited disorders of the immune system, predisposing individuals to recurrent infections, allergy, autoimmunity, and malignancies. Clinical descriptions have already been made for more than 200 PIDs, for which over 150 forms of PID have been molecularly characterized .
A population prevalence of diagnosed PID in the United States at approximately 1 in 1,200 persons.
A part from local registration in some centres there is no national registry of PID in Egypt, and hence, the prevalence of these disorders in the investigator's population is still unknown .
An increasing number of PID are recognized, and effective treatments are possible. Early use of prophylactic antibiotics and replacement immunoglobulin can prevent significant end organ damage and improve long quality of life in these patients .
Immunoglobulin G (IgG) is an essential plasma derived medicine that is lacking in developing countries .IgG shortages leave immune deficient patients without treatment, exposing them to devastating recurrent infections from local pathogens. A simple and practical method for producing IgG from normal plasma collected in developing countries is needed to provide better, faster access to IgG for patients .
Magdy EL-Ekiaby, et al 2010 introduce the concept of small-scale ("minipool") plasma processing methods implementable with minimum infrastructural requirements. They developed viral inactivation and protein purification technologies in single-use equipment to prepare virally safe solvent/detergent-filtered (S/D-F) plasma Producing a 90%pure immunoglobulin fraction in disposable single-use devices for transfusion as well as minipool S/D-F cryoprecipitate to treat bleeding disorders.
研究の種類
入学 (実際)
段階
- 適用できない
連絡先と場所
研究場所
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Assiut、エジプト
- Faculty of Medicine
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
説明
Inclusion Criteria:
- Age group: children patients under 18 years.
- The study will include patient diagnosed as primary immunodeficiency disease (PID) in Assiut university hospital on standard IVIG therapy.
Exclusion Criteria:
- Patient has SCID.
- Patient with history of severe IVIG side effect.
- Patient with severe immunodeficiency and has severe disseminated infection.
- Patient with renal impairment
- Patient with hepatic cell failure
- Patient with endocrinal abnormalities
- patient with secondary immunodeficiency diseases
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 主な目的：処理
- 割り当て：なし
- 介入モデル：単一グループの割り当て
- マスキング：なし（オープンラベル）
武器と介入
参加者グループ / アーム |
介入・治療 |
|---|---|
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実験的：minipooled- Intravenous immunoglobulin(MP-IVIG)
• MP-IVIG equivalent to 1 g/ kg of standard IVIG over a 6-hour to 8-hour period monthly alternated by standard IVIG for a period of 12 months follow up and the newly diagnosed cases admitted to AUH in the follow up period will be included.
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The process of MP-IVIG preparation will involve the use of caprylic acid for purification and virus inactivation of Igs from mini-pools of 20 plasma donations collected in our CBTS in AUH.
The equipment used for the process comprised disposable blood bags, hemodialyzers, and purification and microbial filters.
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この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Efficacy of MP-IVIG assessed by the incidence of acute Serious Bacterial infections(SBIs)
時間枠：1 year
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The rate of Acute SBIs for each participant per 1 year will be assessed by questionnaire (Serious Bacterial Infections) include sign and symptoms of acute serious bacterial infections, i.e. bacterial pneumonia, bacteremia/sepsis, bacterial meningitis, osteomyelitis/ septic arthritis, visceral abscess.
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1 year
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Safty of MP-IVIG assessed by percentage of adverse Events
時間枠：72 hour after adminstration of MP-IVIG and betwen infusions period
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Overall percentage of adverse events as hemolysis and anaphylaxis headache and other complains that occur during 72 hours of following an infusion of MP-IVIG will be assessed by1) vital sign(pulse,blood pressure,Respiratory rate and temprature 2)Hemolysis by hemoglobin level,LDH,billirubin level.2)lbetwen
infusions by home diaries.
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72 hour after adminstration of MP-IVIG and betwen infusions period
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Study the pharmacokinetics- MP-IVIG trough levels
時間枠：predose sample
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MP-IVIG trough level concentration values of serum total IgG pre the MP-IVIG infusion (if applicable). |
predose sample
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Study the pharmacokinetics MP-IVIG plasma concentration -time curve
時間枠：(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Blood samples for analysis of pharmacokinetics MP-IVIG plasma concentration -time curve were obtained and analysed
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(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Study the pharmacokinetics MP-IVIG half-life
時間枠：(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Blood samples for analysis of pharmacokinetics MP-IVIG haf-life were obtained and analysed
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(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Study the pharmacokinetics MP-IVIG area under the curve
時間枠：(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Blood samples for analysis of pharmacokinetics MP-IVIG haf-life were obtained and analysed
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(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Study the pharmacokinetics MP-IVIG Cmax
時間枠：(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Blood samples for analysis of pharmacokinetics MP-IVIG Cmax were obtained and analysed
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(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Study the pharmacokinetics of MP-IVIG-Tmax.
時間枠：(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Blood samples for analysis of pharmacokinetics MP-IVIG Tmax were obtained and analysed
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(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Study the pharmacokinetics of MP-IVIG elimination rate constant(s).
時間枠：(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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Blood samples for analysis of pharmacokinetics MP-IVIG elimination rate constant(s) were obtained and analysed
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(1 hour, 2 hours and 1, 2, 3, 7, 14 and 21 days) post-dose
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二次結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
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Compare efficacy of MP-IVIG vs standard IVIG by compare incidence of SBIs of both
時間枠：1 year
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• Compare the efficacy of MP-IVIG to standard IVIG in children with Primary immunodeficiency disease (PID).
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1 year
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協力者と研究者
スポンサー
捜査官
- スタディディレクター：Maha A Mohammed, professor、Assiut University
出版物と役立つリンク
一般刊行物
- El-Ekiaby M, Sayed MA, Caron C, Burnouf S, El-Sharkawy N, Goubran H, Radosevich M, Goudemand J, Blum D, de Melo L, Soulie V, Adam J, Burnouf T. Solvent-detergent filtered (S/D-F) fresh frozen plasma and cryoprecipitate minipools prepared in a newly designed integral disposable processing bag system. Transfus Med. 2010 Feb;20(1):48-61. doi: 10.1111/j.1365-3148.2009.00963.x. Epub 2009 Sep 23.
- Boyle JM, Buckley RH. Population prevalence of diagnosed primary immunodeficiency diseases in the United States. J Clin Immunol. 2007 Sep;27(5):497-502. doi: 10.1007/s10875-007-9103-1. Epub 2007 Jun 19.
- Reda SM, Afifi HM, Amine MM. Primary immunodeficiency diseases in Egyptian children: a single-center study. J Clin Immunol. 2009 May;29(3):343-51. doi: 10.1007/s10875-008-9260-x. Epub 2008 Nov 11.
- Piguet D, Tosi C, Luthi JM, Andresen I, Juge O; Study investigators. Redimune NF Liquid, a ready-to-use, high-concentration intravenous immunoglobulin therapy preparation, is safe and typically well tolerated in the routine clinical management of a broad range of conditions. Clin Exp Immunol. 2008 Apr;152(1):45-9. doi: 10.1111/j.1365-2249.2008.03597.x. Epub 2008 Jan 28.
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (実際)
研究の完了 (実際)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
本研究に関する用語
追加の関連 MeSH 用語
その他の研究ID番号
- IVIG in PID
医薬品およびデバイス情報、研究文書
米国FDA規制医薬品の研究
米国FDA規制機器製品の研究
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