Retinal Capillary Vessel Density and Foveal Avascular Zone Size in Patients With Psoriatic Arthritis: A Case-Control Study. (PsA-RETINA)
Evaluation of Retinal Capillary Vascular Structures and the Foveal Avascular Zone in Patients With Psoriatic Arthritis.
In terms of blood flow per unit of tissue, the retina is one of the tissues with the highest blood flow in the body. Parameters such as the thickness of the choroid layer, which plays a crucial role in maintaining normal eye function, the dimensions of the foveal avascular zone (FAZ) supplied by this layer, and retinal vascular networks can be measured using non-invasive methods. OCTA (Optical Coherence Tomography Angiography) is an imaging tool that enables the non-invasive assessment of retinal microvascular densities and the measurement of the foveal avascular zone's dimensions. Studies conducted to date indicate that retinal capillary vessels and the dimensions of the foveal avascular zone are affected in rheumatological diseases, especially associated with systemic inflammation. This study aims to compare retinal capillary vessel density and foveal avascular zone dimensions in patients with psoriatic arthritis against those in a healthy population and in patients with psoriasis who do not have psoriatic arthritis, utilizing the non-invasive method of optical coherence tomography angiography.
調査の概要
詳細な説明
In terms of blood flow per unit of tissue, the retina is one of the tissues with the highest blood flow in the body. Non-invasive methods allow for the measurement of-and the detection of changes in-the thickness of the choroid layer (which plays a crucial role in maintaining normal eye function), the foveal avascular zone (nourished by this layer), and the retinal vascular networks. OCTA (Optical Coherence Tomography Angiography) is an imaging tool capable of non-invasively assessing retinal microvascular densities and measuring the dimensions of the foveal avascular zone. Retinal microvascular structures can be affected by systemic pathologies, including various eye diseases. In recent years, there has been growing evidence indicating that retinal vessel densities-as detected by OCTA-are significantly altered and the dimensions of the foveal avascular zone differ in patients with connective tissue diseases, vasculitis, and spondylitis. Psoriatic arthritis is a common chronic inflammatory disease characterized by both spondyloarthropathy and peripheral arthritis involvement. There is currently no data in the literature regarding the status of the choroidal vasculature-a highly perfused tissue-in patients with psoriatic arthritis or its relationship with disease activity. In this study, we aimed to compare retinal capillary density and foveal avascular zone dimensions among patients with psoriatic arthritis, patients with psoriasis, and healthy individuals using OCTA. The study will also compare findings between subgroups of psoriatic patients with and without concomitant spondylitis.
研究の種類
入学 (推定)
連絡先と場所
研究連絡先
- 名前：Koray Ayar, Associated Proffessor
- 電話番号：1648 +90 224-2955000
- メール：ayarkoray@hotmail.com
研究場所
-
-
Yıldırım
-
Bursa、Yıldırım、トルコ（Türkiye）、16130
- 募集
- University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital
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コンタクト：
- Koray Ayar
- 電話番号：05325618450
- メール：ayarkoray@hotmail.com
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コンタクト：
- Koray Ayar, Associated Proffessor (Dr.)
- 電話番号：1648 +90 224-2955000
- メール：ayarkoray@hotmail.com
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主任研究者：
- Koray Ayar, Associated Proffessor (Dr.)
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副調査官：
- Neslihan Parmak Yener, Associated Proffessor
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参加基準
適格基準
就学可能な年齢
健康ボランティアの受け入れ
受講資格のある性別
サンプリング方法
調査対象母集団
The study population consists of volunteers from among patients with psoriatic arthritis who are being followed at the study center's rheumatology clinic. The patient control group comprises volunteers diagnosed with psoriasis by a specialist dermatologist. Participants in the healthy control group are healthcare workers or patient companions matched for age and gender with the patient group and the patient control group.
説明
Inclusion Criteria:
- Volunteers diagnosed with psoriatic arthritis according to CASPAR criteria
- Volunteers diagnosed with psoriasis by a specialist dermatologist
- Hospital staff or patient companions with no chronic illnesses
Exclusion Criteria:
- Diabetes mellitus
- Cancer
- Pregnancy or lactation
- Chronic renal failure
- Glocome
- History of eye surgery
- History of eye trauma
研究計画
研究はどのように設計されていますか？
デザインの詳細
- 観測モデル：CASE_CONTROL
- 時間の展望：PROSPECTIVE
コホートと介入
グループ/コホート |
介入・治療 |
|---|---|
|
Psoriatic arthritis
Participants with psoriatic arthritis |
Vessel density of retinal superficial capillary plexus Vessel density of retinal deep capillary plexus Vessel density of retinal prepapillary capillaries FAZ essessment parameters |
|
Psoriasis
Psoriasis participants with no other known systemic inflammatory disease |
Vessel density of retinal superficial capillary plexus Vessel density of retinal deep capillary plexus Vessel density of retinal prepapillary capillaries FAZ essessment parameters |
|
Healthy controls
Patient companions or hospital staff with no known chronic illnesses |
Vessel density of retinal superficial capillary plexus Vessel density of retinal deep capillary plexus Vessel density of retinal prepapillary capillaries FAZ essessment parameters |
この研究は何を測定していますか？
主要な結果の測定
結果測定 |
メジャーの説明 |
時間枠 |
|---|---|---|
|
Retinal SCP, VD
時間枠：1 day
|
Vessel density of retinal superficial capillary plexus |
1 day
|
|
Retinal DCP, VD
時間枠：1 day
|
Vessel density of retinal deep capillary plexus |
1 day
|
|
Retinal RCP, VD
時間枠：1 day
|
Vessel density of retinal prepapillary capillaries |
1 day
|
|
FAZ parameters
時間枠：1 day
|
Foveal avasculary assessment parameters |
1 day
|
協力者と研究者
研究記録日
主要日程の研究
研究開始 (実際)
一次修了 (推定)
研究の完了 (推定)
試験登録日
最初に提出
QC基準を満たした最初の提出物
最初の投稿 (実際)
学習記録の更新
投稿された最後の更新 (実際)
QC基準を満たした最後の更新が送信されました
最終確認日
詳しくは
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